CN109091433A - A kind of composition of oil control and acne removal and its application in cosmetics - Google Patents
A kind of composition of oil control and acne removal and its application in cosmetics Download PDFInfo
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
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Abstract
The invention discloses a kind of oil control and acne removal composition and its application, the composition can releive the skin of calm inflammation, get through skin moisture channel, adjust Epidermal Microenvironment, so that anti-acne foster skin, rebuilds skin barrier function, protect skin from extraneous stimulation;Technical points are that the composition mainly includes the component of following parts by weight: 2-8 parts of lycium barbarum berry extract, 1-7 parts of Echinacea angustifolia extract, 2-7 parts of algaroba berry extract, 3-7 parts of white willow bark extract, 0.7-5 parts of tetrahydro methylpyrimidine carboxylic acid, 3-8 parts of inositol, 0.3-3 parts of extractive of usnea of palpus;Belong to cosmetic technical field.
Description
Technical field
The invention discloses a kind of compositions, specifically, being a kind of oil control and acne removal composition and its in cosmetics
Using belonging to cosmetic technical field.
Background technique
With the aggravation of the reasons such as life stress, irregular, food safety of living, environment influence, it is many that small pox becomes puzzlement
One of the skin problem of more young men.In recent years with beauty marketing education deeply and it is universal, small pox has been subjected to people's
Pay attention to, and the also thus expansion rapidly of the market potential of product for resolving poxes.According to " the white skin of anti-acne for combining publication with Watson than Du Ke
Book " investigational data can be seen that 2018-2020, Cosmetic Market will welcome anti-acne upsurge.
Research and development for oil control and acne removal product, it is necessary first to understand small pox formation mechenism.Small pox is a kind of pilosebaceous follicle
Chronic inflammation, be common in the youth of both sexes of adolescence, occur mainly in face, preceding chest muscle scapular region position, formed papule,
Chinese medicine claims " acne ", and doctor trained in Western medicine is known as " acne ".
Puberty, smegma increased since male sex hormone increases, while making the different hyperkeratinization of hair follicle, sebaceous glands, angle
The flat dead cell that matter layer falls off falls hair follicle pars infundibularis, in conjunction with sebum, generates mixture.If these mixtures cannot
It is freely discharged skin surface, and deposits in then will form rouge bolt in hair follicle.When these dyskeratosis cell aggregations, lower hopper is swollen
Mature acne are just formed when swollen.Sebum bacterial decomposition present in hair follicle generates fatty acid, and the latter's hair follicle stimulating causes inflammation
Disease causes follicular wall lesion ruptures, and hair follicle content enters corium, so as to cause the inflammatory reaction of perifollicolar varying degree.
The pathogenic factors of small pox be it is various, endocrine is one of factor.In the mistake that acne are inflamed
Cheng Zhong, bacterium play a very important role.In skin surface and sebaceous glands hair follicle, it is understood that there may be some microorganisms, often
That sees has Propiobacterium, staphylococcus epidermis etc., with the maximum that is related of Propiobacterium and acne inflammation.
In general, the functional agent of product for resolving poxes addition determines the function of product.Many product for resolving poxes make currently on the market
Antibacterial and anti-inflammatory are carried out with antibiotic such as metronidazoles, this kind of product has certain effect to small pox, acne etc. are eliminated, but long-term
Using skin can be stimulated, cause contact dermatitis, show as erythema, oedema, erosion, itch etc., more seriously causes to fight
The drug resistance of raw element, causes healthy hidden danger.
Therefore, develop that a kind of safety is without side-effects, the good skin care compositions of anti-acne effect and cosmetics are green and healthyization
The market of cosmetic is become.
Summary of the invention
In view of the above deficiencies, the object of the present invention is to provide a kind of oil control and acne removal composition, the composition can releive town
The skin of quiet inflammation gets through skin moisture channel, adjusts Epidermal Microenvironment, so that anti-acne foster skin, rebuilds skin barrier function, protects
Skin is protected from extraneous stimulation.
A second object of the present invention is to provide the applications of above-mentioned oil control and acne removal composition.
To realize that above-mentioned effect, first technical solution provided by the invention are such that
A kind of oil control and acne removal composition mainly includes the component of following parts by weight: 2-8 parts of lycium barbarum berry extract, purple
1-7 parts of echinacea extract, 2-7 parts of algaroba berry extract, 3-7 parts of white willow bark extract, tetrahydro methylpyrimidine carboxylic acid
0.7-5 parts, 3-8 parts of inositol, 0.3-3 parts of extractive of usnea of palpus.
Further, above-mentioned a kind of oil control and acne removal composition, the composition include: 1-6 parts of blunt horse hair algae extract.
Further, above-mentioned a kind of oil control and acne removal composition, the composition include: Candida/glucose/rape
0.9-4 parts of seed methyl oleate tunning.
Further, above-mentioned a kind of oil control and acne removal composition, is made of: lycium barbarum fruit following components in parts by weight
3-7 parts of extract, 2-6 parts of Echinacea angustifolia extract, 3-6 parts of algaroba berry extract, 4-6 parts of white willow bark extract, tetrahydro
1-4 parts of methylpyrimidine carboxylic acid, 4-7 parts of inositol, palpus 0.5-2 parts of extractive of usnea, 2-5 parts of blunt horse hair algae extract.
Further, above-mentioned a kind of oil control and acne removal composition, is made of: lycium barbarum fruit following components in parts by weight
3-7 parts of extract, 2-6 parts of Echinacea angustifolia extract, 3-6 parts of algaroba berry extract, 4-6 parts of white willow bark extract, tetrahydro
1-4 parts of methylpyrimidine carboxylic acid, 4-7 parts of inositol, palpus 0.5-2 parts of extractive of usnea, Candida/glucose/rapeseed oleic acid first
1-3 parts of ester tunning.
Further, above-mentioned a kind of oil control and acne removal composition, is made of: lycium barbarum fruit following components in parts by weight
4-6 parts of extract, 3-5 parts of Echinacea angustifolia extract, 4-5 parts of algaroba berry extract, 5-6 parts of white willow bark extract, tetrahydro
2-3 parts of methylpyrimidine carboxylic acid, 5-6 parts of inositol, palpus 1-2 parts of extractive of usnea, 3-4 parts of blunt horse hair algae extract, Candida/Portugal
Grape sugar/1-2 parts of rapeseed methyl oleate tunning.
Another technical solution provided by the invention, which is to provide, contains the oil control and acne removal composition as cosmetic additive agent
Application, the cosmetics be water, essence, lotion, face cream, gel, facial mask.
Further, additive amount of the above-mentioned oil control and acne removal composition in cosmetics is the 0.01- of cosmetics gross mass
3%.
Compared with prior art, beneficial effects of the present invention:
(1) in technical solution provided by the invention, when white willow bark extract, inositol, algaroba berry extract, purple pine nut
When chrysanthemum extract, the interaction of lycium barbarum berry extract, by the Penetration enhancing effect of inositol, so that white willow bark extract etc.
Effective component can go directly cuticula, eliminate silent.Composition can decompose excessive sebum simultaneously, inhibit sebum secretion excessively prosperous,
Skin is enabled to reach preferable oil-water balance.And the palpus extractive of usnea, tetrahydro methylpyrimidine carboxylic acid in composition pass through inositol
Penetration enhancing effect being capable of antibacterial anti-inflammatory well.
(2) in technical solution provided by the invention, when blunt horse hair algae extract is added in composition, it can be improved group
It closes object and adjusts water and oil balance ability, reduce fat secretion, keep the skin wet.And Candida/glucose/rapeseed methyl oleate hair
Ferment product and tetrahydro methylpyrimidine carboxylic acid interact to form hydration shell, protect cell, and acne print is repaired in help, and gentle skin makes
Skin is smooth.
Specific embodiment
With reference to embodiment, claim of the invention is described in further detail, but do not constituted pair
Any restrictions of the invention, the modification of anyone limited times made in the claims in the present invention protection scope, still in this hair
Within bright claims.
It should be noted that raw material employed in skill scheme provided by the invention passes through routine unless otherwise specified
Means preparation is bought by commercial channel.Wherein, blunt horse hair algae extract is purchased from the bright limited public affairs of biotechnology of Guangzhou remittance
Department;Candida/glucose/rapeseed methyl oleate tunning is purchased from Guangzhou Ao Xue Chemical Co., Ltd..
Embodiment 1
A kind of oil control and acne removal composition provided by the invention, is grouped as by the group of following weight number: lycium barbarum fruit is extracted
2 parts of object, 7 parts of Echinacea angustifolia extract, 7 parts of algaroba berry extract, 3 parts of white willow bark extract, tetrahydro methylpyrimidine carboxylic acid
0.7 part, 3 parts of inositol, 3 parts of extractive of usnea of palpus.
Embodiment 2
A kind of oil control and acne removal composition provided by the invention, is grouped as by the group of following weight number: lycium barbarum fruit is extracted
8 parts of object, 1 part of Echinacea angustifolia extract, 2 parts of algaroba berry extract, 7 parts of white willow bark extract, tetrahydro methylpyrimidine carboxylic acid
5 parts, 8 parts of inositol, 0.3 part of extractive of usnea of palpus.
Embodiment 3
A kind of oil control and acne removal composition provided by the invention, is grouped as by the group of following weight number: lycium barbarum fruit is extracted
6 parts of object, 4 parts of Echinacea angustifolia extract, 5 parts of algaroba berry extract, 4 parts of white willow bark extract, tetrahydro methylpyrimidine carboxylic acid
2 parts, 5 parts of inositol, 1 part of extractive of usnea of palpus.
Embodiment 4
A kind of oil control and acne removal composition provided by the invention, is grouped as by the group of following weight number: lycium barbarum fruit is extracted
3 parts of object, 2 parts of Echinacea angustifolia extract, 6 parts of algaroba berry extract, 4 parts of white willow bark extract, tetrahydro methylpyrimidine carboxylic acid
4 parts, 3 parts of inositol, 2 parts of extractive of usnea of palpus, 1 part of blunt horse hair algae extract.
Embodiment 5
A kind of oil control and acne removal composition provided by the invention, is grouped as by the group of following weight number: lycium barbarum fruit is extracted
7 parts of object, 6 parts of Echinacea angustifolia extract, 3 parts of algaroba berry extract, 4 parts of white willow bark extract, tetrahydro methylpyrimidine carboxylic acid
1 part, 3 parts of inositol, 0.5 part of extractive of usnea of palpus, 6 parts of blunt horse hair algae extract.
Embodiment 6
A kind of oil control and acne removal composition provided by the invention, is grouped as by the group of following weight number: lycium barbarum fruit is extracted
6 parts of object, 3 parts of Echinacea angustifolia extract, 4 parts of algaroba berry extract, 5 parts of white willow bark extract, tetrahydro methylpyrimidine carboxylic acid
2 parts, 5 parts of inositol, 1 part of extractive of usnea of palpus, Candida/glucose/0.9 part of rapeseed methyl oleate tunning.
Embodiment 7
A kind of oil control and acne removal composition provided by the invention, is grouped as by the group of following weight number: lycium barbarum fruit is extracted
3 parts of object, 2 parts of Echinacea angustifolia extract, 6 parts of algaroba berry extract, 4 parts of white willow bark extract, tetrahydro methylpyrimidine carboxylic acid
4 parts, 4 parts of inositol, 2 parts of extractive of usnea of palpus, Candida/glucose/4 parts of rapeseed methyl oleate tunning.
Embodiment 8
A kind of oil control and acne removal composition provided by the invention, is grouped as by the group of following weight number: lycium barbarum fruit is extracted
4 parts of object, 3 parts of Echinacea angustifolia extract, 5 parts of algaroba berry extract, 6 parts of white willow bark extract, tetrahydro methylpyrimidine carboxylic acid
2 parts, 6 parts of inositol, 2 parts of extractive of usnea of palpus, 3 parts of blunt horse hair algae extract, Candida/glucose/rapeseed methyl oleate
1 part of tunning.
Embodiment 9
A kind of oil control and acne removal composition provided by the invention, is grouped as by the group of following weight number: lycium barbarum fruit is extracted
6 parts of object, 5 parts of Echinacea angustifolia extract, 4 parts of algaroba berry extract, 5 parts of white willow bark extract, tetrahydro methylpyrimidine carboxylic acid
3 parts, 5 parts of inositol, 1 part of extractive of usnea of palpus, 4 parts of blunt horse hair algae extract, Candida/glucose/rapeseed methyl oleate
2 parts of tunning.
In order to prove that effect of the invention, the application are also provided with following comparative example, with embodiment provided by the present application into
Row Contrast on effect:
Comparative example 1
A kind of composition is provided in comparative example 1, is grouped as by the group of following weight number: 6 parts of lycium barbarum berry extract, purple
4 parts of echinacea extract, 5 parts of algaroba berry extract, 4 parts of white willow bark extract, 5 parts of inositol, 1 part of extractive of usnea of palpus.
Comparative example 2
A kind of composition is provided in comparative example 2, is grouped as by the group of following weight number: 1 part of lycium barbarum berry extract, purple
8 parts of echinacea extract, 1 part of algaroba berry extract, 1 part of white willow bark extract, 6 parts of tetrahydro methylpyrimidine carboxylic acid, inositol 1
Part, 4 parts of extractive of usnea of palpus.
Comparative example 3
A kind of composition is provided in comparative example 3, is grouped as by the group of following weight number: is 1 part of tetrahydro methylpyrimidine carboxylic acid, blunt
2 parts of horse hair algae extract, Candida/glucose/2 parts of rapeseed methyl oleate tunning.
The preparation method of above-mentioned composition is to weigh each component according to any one group of weight number in embodiment 1 to 9, and suitable
The deionized water of amount is mixed evenly.
When specifically used, any one group of composition in embodiment 1 to 9 is directly appended to respectively in 40 DEG C or so of low temperature
It is mixed in the skin care item of kind of dosage form, such as water-based, essence matrix, emulsion matrix, face cream matrix, gel matrix, mask matrix,
Additive amount be gross mass 0.01-3%, preferably 1.2%.
It should be noted that water-based, essence matrix, emulsion matrix, face cream matrix, gel matrix, mask matrix are this
Field conventional substrate.
The composition of 1-9 of the embodiment of the present invention, comparative example 1-3 is given below in order to better illustrate the present invention the advantages of
Composition be added in oil control and acne removal equilibrium water, the mass percent that composition accounts for equilibrium water is 1.2%.It also sets up simultaneously
It is as follows to carry out efficacy test to the oil control and acne removal equilibrium water of preparation for blank group toner without containing the present composition:
A kind of oil control and acne removal equilibrium water provided by the invention, is mainly made of following raw material and proportion:
1. oil-control effect test
(1) test method: choosing 78 age 22~40 years old volunteers, wherein male 30, and women 48, random point
It is 13 groups.Volunteer is oiliness and Combination skin, without any skin disease and skin allergy history, cannot use within test first 2 days and appoint
What cosmetics is smeared 2 times using the daily morning and evening, and any cosmetics other than test sample must not be used during test.It uses
It is preceding and using follow-up and test are primary respectively after 4,8 weeks.Random enrolled form is taken to carry out.Technical staff uses skin oil and fat
Test probe and moisture measurement probe are tested forehead skin 3 times, are averaged, are acquired blank value for the first time.
(2) test equipment: the cuotometer of German Courage+Khazaka company (German CK company) manufacture
MPA580 grease test probe Sebumeter SM815, moisture of skin tester Corneometer CM825.
(3) interpretation of result: fat content variation is reflected in test area fat content in test period and changes over time rule
Rule, moisture content change reaction test region moisturizing situation.Concrete outcome is referring to table 1.
The use of table 1 is preceding and uses rear different time forehead skin oil and fat content and moisture content
From table 1 it follows that skin oil and fat content is the after using equilibrium water made from embodiment 1-9 for a period of time
Have already appeared within 4 weeks more apparent reduction trend.Use the grease within 8 weeks of toner made from comparative example 1~3 and blank group
Content is reduced, but reduces to be not obvious.So in terms of controlling fat secretion, the specific composition of the present composition
It acts synergistically with proportion, so that the oil-control better effect of composition.Meanwhile from moisture content as can be seen that embodiment is than comparison
It is more that the skin care item of example and blank group increase the moisture content of skin, and moisturizing effect is more obvious.
2. bacteriostasis efficacy is tested
It is " disposable to defend referring to GB15979-2002 to verify composition of the present invention in the effect of antibiosis
Raw articles sanitary standard " appendix C 4 " stripping property resists (suppression) bacterium product bacteriostasis property test method " is to the embodiment of the present invention 1~9
With comparative example 1~3, blank group composition made from anti-acne equilibrium water and toner carry out bacteriostasis property measurement:
(1) preparation of bacteria suspension: taking propionibacterium acnes, staphylococcus aureus, Escherichia coli, culture is used for 24 hours
0.03mol/L phosphate buffer is washed down, and 104~106CFU/mL bacteria suspension is made;
(2) it is taken respectively by test agent 1g, the mixing of above-mentioned bacteria suspension 0.1mL even spread is added, start timing, after 20min
9mL0.03mol/L phosphate buffer is added to mix well, after doing appropriate dilution, takes wherein 3 dilutions, takes 1mL to set respectively
In two parallel plates, adds corresponding culture medium and cultivated 24 hours under 36 ± 1 DEG C of anaerobic conditions, make bacterium colony counting.With
Upper test is repeated 3 times, and is averaged, and blank control group is arranged.
The calculation formula of bacteriostasis rate are as follows: X=(A-B)/A × 100%, wherein X is bacteriostasis rate, and A is that control sample averagely returns
Bacterium colony is received, B is that test specimen averagely recycles bacterium colony.
Acne-removing evaluation criterion are as follows: (1) bacteriostasis rate >=90% is effective;(2) it is effective that bacteriostasis rate, which is 50~90%,;
(3) bacteriostasis rate < 50% is invalid.
The evaluation of skin care item bacteriostasis efficacy made from Examples 1 to 9, comparative example 1~3 and blank group is shown in Table 2.
The bacteriostasis efficacy result of 2 skin care item of table
It can be seen that the skin care item containing embodiment 1-9 composition to propionibacterium acnes, golden yellow from the data of table 2
Staphylococcus, Escherichia coli have stronger fungistatic effect, acne-removing be evaluated as it is effective or effective, bacteriostasis rate 80% with
On.The skin care item of comparative example 1~3 and blank group are equal to propionibacterium acnes, staphylococcus aureus, the bacteriostasis rate of Escherichia coli
Lower than 50%, bacteriostasis efficacy is invalid.Illustrate only when the present composition is combined with special component and ratio, energy
It is enough that effective fungistatic effect is played to the viral bacterium such as propionibacterium acnes, staphylococcus aureus, Escherichia coli.In addition, from knot
In fruit it can also be seen that when being extracted in composition containing appropriate lycium barbarum berry extract, Echinacea angustifolia extract, algaroba fruit
Object, white willow bark extract, tetrahydro methylpyrimidine carboxylic acid, inositol, palpus extractive of usnea, blunt horse hair algae extract, Candida/
When glucose/rapeseed methyl oleate tunning, the fungistatic effect of composition can be made to play best, bacteriostasis rate reaches >=
99% or more.
3. pressing down acne compliance test result test
1) test crowd: selection skin characteristic is Oily, slight and moderate whelk skin subject totally 80 people,
Age 18-35 years old, 8 groups are randomly divided into, every group of 10 people.
2) test specimen: the equilibrium water and blank group toner of embodiment 3,5,7,9 and the preparation of 1~3 composition of comparative example.
3) test method:
Test specimen is used after the above daily morning and evening face cleaning of each group subject, after 28 days, subject is to suppression acne effect
Use feeling evaluation is carried out, evaluation result is counted per capita, is specifically shown in Table 3.
3 anti-acne effect of table
It can be seen from the result of table 3 after being added to equilibrium water for a period of time using example composition, cosmetics
Anti-acne effect evaluation is substantially better than cosmetic effect obtained by comparative example and blank group.It therefore, can from the anti-acne effect in table 3
To find out, ingredient of the invention is synergistic, is inhibiting the effect of small pox obvious.
The above embodiment is a preferred embodiment of the present invention, but embodiments of the present invention are not by above-described embodiment
Limitation, other any changes, modifications, substitutions, combinations, simplifications made without departing from the spirit and principles of the present invention,
It should be equivalent substitute mode, be included within the scope of the present invention.
Claims (9)
1. a kind of oil control and acne removal composition, which is characterized in that mainly include the component of following parts by weight: lycium barbarum berry extract
2-8 parts, 1-7 parts of Echinacea angustifolia extract, 2-7 parts of algaroba berry extract, 3-7 parts of white willow bark extract, tetrahydro methyl it is phonetic
0.7-5 parts of pyridine carboxylic acid, 3-8 parts of inositol, 0.3-3 parts of extractive of usnea of palpus.
2. a kind of oil control and acne removal composition according to claim 1, which is characterized in that the composition further includes blunt horse hair
1-6 parts of algae extract.
3. a kind of oil control and acne removal composition according to claim 1 or 2, which is characterized in that the composition further includes vacation
Silk yeast/glucose/0.9-4 parts of rapeseed methyl oleate tunning.
4. a kind of oil control and acne removal composition according to claim 2, which is characterized in that by following components in parts by weight group
At: 3-7 parts of lycium barbarum berry extract, 2-6 parts of Echinacea angustifolia extract, 3-6 parts of algaroba berry extract, white willow bark extract
4-6 parts of object, 1-4 parts of tetrahydro methylpyrimidine carboxylic acid, 4-7 parts of inositol, palpus 0.5-2 parts of extractive of usnea, blunt horse hair algae extract 2-5
Part.
5. a kind of oil control and acne removal composition according to claim 3, which is characterized in that by following components in parts by weight group
At: 3-7 parts of lycium barbarum berry extract, 2-6 parts of Echinacea angustifolia extract, 3-6 parts of algaroba berry extract, white willow bark extract
4-6 parts of object, 1-4 parts of tetrahydro methylpyrimidine carboxylic acid, 4-7 parts of inositol, 0.5-2 parts of extractive of usnea of palpus, Candida/glucose/
1-3 parts of rapeseed methyl oleate tunning.
6. a kind of oil control and acne removal composition according to claim 3, which is characterized in that by following components in parts by weight group
At: 4-6 parts of lycium barbarum berry extract, 3-5 parts of Echinacea angustifolia extract, 4-5 parts of algaroba berry extract, white willow bark extract
5-6 parts of object, 2-3 parts of tetrahydro methylpyrimidine carboxylic acid, 5-6 parts of inositol, palpus 1-2 parts of extractive of usnea, blunt horse hair algae extract 3-4
Part, Candida/glucose/1-2 parts of rapeseed methyl oleate tunning.
7. application of any oil control and acne removal composition of claim 1-3 as additive in cosmetics.
8. application of the oil acne-removing composition according to claim 7 as additive in cosmetics, which is characterized in that described
Cosmetics are water or essence or lotion or face cream or gel or facial mask.
9. application of the oil control and acne removal composition according to claim 7 in cosmetics, which is characterized in that the composition
Additive amount is the 0.01-3% of cosmetics gross mass.
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CN111514053A (en) * | 2019-11-06 | 2020-08-11 | 广州妮趣化妆品有限公司 | Composition with acne removing effect and preparation method and application thereof |
CN111803422A (en) * | 2020-08-17 | 2020-10-23 | 山东华熙海御生物医药有限公司 | Oil control composition and application thereof |
CN112006960A (en) * | 2020-09-15 | 2020-12-01 | 广州莱约生物科技有限公司 | Acne-removing and oil-controlling composition and preparation method and application thereof |
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CN112006960A (en) * | 2020-09-15 | 2020-12-01 | 广州莱约生物科技有限公司 | Acne-removing and oil-controlling composition and preparation method and application thereof |
CN113171327A (en) * | 2021-05-06 | 2021-07-27 | 建昌帮药业有限公司 | Oil-control acne-removing composition and application thereof |
CN114712283A (en) * | 2022-04-12 | 2022-07-08 | 北京至乐界生物科技有限公司 | Oil-control acne-clearing composition and application thereof in skin care products |
CN115006329A (en) * | 2022-06-30 | 2022-09-06 | 山东博科医用材料有限公司 | Oil-control moisture-retention pure water |
CN115252445A (en) * | 2022-07-14 | 2022-11-01 | 苏州猫尔科技有限公司 | Composite micro-ecological oil control hair care composition and hair care product |
CN115252445B (en) * | 2022-07-14 | 2024-03-05 | 苏州猫尔科技有限公司 | Composite microecological oil-control hair care composition and hair care product |
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