CN115252445A - Composite micro-ecological oil control hair care composition and hair care product - Google Patents
Composite micro-ecological oil control hair care composition and hair care product Download PDFInfo
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- CN115252445A CN115252445A CN202210833257.XA CN202210833257A CN115252445A CN 115252445 A CN115252445 A CN 115252445A CN 202210833257 A CN202210833257 A CN 202210833257A CN 115252445 A CN115252445 A CN 115252445A
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- hair care
- vitamin
- scalp
- hair
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- 210000004209 hair Anatomy 0.000 title claims abstract description 46
- 239000000203 mixture Substances 0.000 title claims abstract description 45
- 239000002131 composite material Substances 0.000 title claims abstract description 8
- FTSSQIKWUOOEGC-RULYVFMPSA-N fructooligosaccharide Chemical compound OC[C@H]1O[C@@](CO)(OC[C@@]2(OC[C@@]3(OC[C@@]4(OC[C@@]5(OC[C@@]6(OC[C@@]7(OC[C@@]8(OC[C@@]9(OC[C@@]%10(OC[C@@]%11(O[C@H]%12O[C@H](CO)[C@@H](O)[C@H](O)[C@H]%12O)O[C@H](CO)[C@@H](O)[C@@H]%11O)O[C@H](CO)[C@@H](O)[C@@H]%10O)O[C@H](CO)[C@@H](O)[C@@H]9O)O[C@H](CO)[C@@H](O)[C@@H]8O)O[C@H](CO)[C@@H](O)[C@@H]7O)O[C@H](CO)[C@@H](O)[C@@H]6O)O[C@H](CO)[C@@H](O)[C@@H]5O)O[C@H](CO)[C@@H](O)[C@@H]4O)O[C@H](CO)[C@@H](O)[C@@H]3O)O[C@H](CO)[C@@H](O)[C@@H]2O)[C@@H](O)[C@@H]1O FTSSQIKWUOOEGC-RULYVFMPSA-N 0.000 claims abstract description 15
- 229940107187 fructooligosaccharide Drugs 0.000 claims abstract description 15
- 239000002994 raw material Substances 0.000 claims abstract description 8
- 235000019156 vitamin B Nutrition 0.000 claims abstract description 7
- 239000011720 vitamin B Substances 0.000 claims abstract description 7
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 claims description 34
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 claims description 22
- 229940011671 vitamin b6 Drugs 0.000 claims description 17
- DFPAKSUCGFBDDF-UHFFFAOYSA-N nicotinic acid amide Natural products NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims description 13
- 235000019158 vitamin B6 Nutrition 0.000 claims description 13
- 239000011726 vitamin B6 Substances 0.000 claims description 13
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims description 12
- 229930003537 Vitamin B3 Natural products 0.000 claims description 11
- 229960003512 nicotinic acid Drugs 0.000 claims description 11
- 235000019160 vitamin B3 Nutrition 0.000 claims description 11
- 239000011708 vitamin B3 Substances 0.000 claims description 11
- NHZMQXZHNVQTQA-UHFFFAOYSA-N pyridoxamine Chemical compound CC1=NC=C(CO)C(CN)=C1O NHZMQXZHNVQTQA-UHFFFAOYSA-N 0.000 claims description 6
- ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 claims description 5
- 235000019171 pyridoxine hydrochloride Nutrition 0.000 claims description 5
- 239000011764 pyridoxine hydrochloride Substances 0.000 claims description 5
- 229960004172 pyridoxine hydrochloride Drugs 0.000 claims description 5
- 235000008160 pyridoxine Nutrition 0.000 claims description 4
- 239000011677 pyridoxine Substances 0.000 claims description 4
- 239000002453 shampoo Substances 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 claims description 3
- 229960003581 pyridoxal Drugs 0.000 claims description 3
- 235000008164 pyridoxal Nutrition 0.000 claims description 3
- 239000011674 pyridoxal Substances 0.000 claims description 3
- FCHXJFJNDJXENQ-UHFFFAOYSA-N pyridoxal hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(C=O)=C1O FCHXJFJNDJXENQ-UHFFFAOYSA-N 0.000 claims description 3
- 235000008151 pyridoxamine Nutrition 0.000 claims description 3
- 239000011699 pyridoxamine Substances 0.000 claims description 3
- PFIPZKASKUWLHH-UHFFFAOYSA-N pyridoxamine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CN)=C1O PFIPZKASKUWLHH-UHFFFAOYSA-N 0.000 claims description 3
- 229960003966 nicotinamide Drugs 0.000 claims description 2
- 235000005152 nicotinamide Nutrition 0.000 claims description 2
- 239000011570 nicotinamide Substances 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- 210000002966 serum Anatomy 0.000 claims description 2
- 150000003722 vitamin derivatives Chemical class 0.000 claims description 2
- 239000008266 hair spray Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 210000004761 scalp Anatomy 0.000 abstract description 55
- 208000003251 Pruritus Diseases 0.000 abstract description 10
- 230000004888 barrier function Effects 0.000 abstract description 8
- 230000000694 effects Effects 0.000 abstract description 8
- 206010040844 Skin exfoliation Diseases 0.000 abstract description 6
- 206010000496 acne Diseases 0.000 abstract description 6
- 230000035618 desquamation Effects 0.000 abstract description 6
- SCVVSSZVLZQUDZ-UHFFFAOYSA-N 3-methyl-2,6-dihydro-1H-pyrimidine-2-carboxylic acid Chemical compound CN1C(NCC=C1)C(=O)O SCVVSSZVLZQUDZ-UHFFFAOYSA-N 0.000 abstract description 5
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 abstract description 5
- 206010061218 Inflammation Diseases 0.000 abstract description 5
- 230000004054 inflammatory process Effects 0.000 abstract description 5
- 229960000367 inositol Drugs 0.000 abstract description 5
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 abstract description 5
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 abstract description 5
- 239000002537 cosmetic Substances 0.000 abstract description 2
- 239000000047 product Substances 0.000 description 19
- 230000028327 secretion Effects 0.000 description 15
- 210000002374 sebum Anatomy 0.000 description 13
- 239000004519 grease Substances 0.000 description 7
- 150000002632 lipids Chemical class 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- 241000894006 Bacteria Species 0.000 description 6
- 210000004027 cell Anatomy 0.000 description 6
- 230000008859 change Effects 0.000 description 6
- 230000036572 transepidermal water loss Effects 0.000 description 6
- 238000000034 method Methods 0.000 description 5
- 210000003491 skin Anatomy 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 4
- 229930006000 Sucrose Natural products 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 210000003780 hair follicle Anatomy 0.000 description 4
- 244000005700 microbiome Species 0.000 description 4
- 230000008439 repair process Effects 0.000 description 4
- 210000001732 sebaceous gland Anatomy 0.000 description 4
- 239000005720 sucrose Substances 0.000 description 4
- 229920000832 Cutin Polymers 0.000 description 3
- 229930091371 Fructose Natural products 0.000 description 3
- 239000005715 Fructose Substances 0.000 description 3
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
- 241000555676 Malassezia Species 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 3
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 3
- 239000008103 glucose Substances 0.000 description 3
- 239000003906 humectant Substances 0.000 description 3
- 230000007803 itching Effects 0.000 description 3
- 238000012423 maintenance Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 239000003755 preservative agent Substances 0.000 description 3
- 230000002335 preservative effect Effects 0.000 description 3
- 230000001105 regulatory effect Effects 0.000 description 3
- 239000007921 spray Substances 0.000 description 3
- 239000002562 thickening agent Substances 0.000 description 3
- TXFPEBPIARQUIG-UHFFFAOYSA-N 4'-hydroxyacetophenone Chemical compound CC(=O)C1=CC=C(O)C=C1 TXFPEBPIARQUIG-UHFFFAOYSA-N 0.000 description 2
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 2
- 208000001840 Dandruff Diseases 0.000 description 2
- 206010013786 Dry skin Diseases 0.000 description 2
- NPGIHFRTRXVWOY-UHFFFAOYSA-N Oil red O Chemical compound Cc1ccc(C)c(c1)N=Nc1cc(C)c(cc1C)N=Nc1c(O)ccc2ccccc12 NPGIHFRTRXVWOY-UHFFFAOYSA-N 0.000 description 2
- 206010039792 Seborrhoea Diseases 0.000 description 2
- 239000002585 base Substances 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 239000012091 fetal bovine serum Substances 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 230000003648 hair appearance Effects 0.000 description 2
- 238000011835 investigation Methods 0.000 description 2
- 230000002503 metabolic effect Effects 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000001953 sensory effect Effects 0.000 description 2
- 238000010186 staining Methods 0.000 description 2
- 238000007619 statistical method Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 210000000106 sweat gland Anatomy 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical group CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 1
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 201000004384 Alopecia Diseases 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 239000005995 Aluminium silicate Substances 0.000 description 1
- 206010013082 Discomfort Diseases 0.000 description 1
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 241000208690 Hamamelis Species 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
- 241000736262 Microbiota Species 0.000 description 1
- 241000186429 Propionibacterium Species 0.000 description 1
- 206010039793 Seborrhoeic dermatitis Diseases 0.000 description 1
- 241000191940 Staphylococcus Species 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 238000000692 Student's t-test Methods 0.000 description 1
- 229930003270 Vitamin B Natural products 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 231100000360 alopecia Toxicity 0.000 description 1
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 description 1
- 235000012211 aluminium silicate Nutrition 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 230000003915 cell function Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000037336 dry skin Effects 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 230000002996 emotional effect Effects 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 239000006481 glucose medium Substances 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
- ACCCMOQWYVYDOT-UHFFFAOYSA-N hexane-1,1-diol Chemical compound CCCCCC(O)O ACCCMOQWYVYDOT-UHFFFAOYSA-N 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 210000002510 keratinocyte Anatomy 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000037312 oily skin Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 238000007427 paired t-test Methods 0.000 description 1
- UWJJYHHHVWZFEP-UHFFFAOYSA-N pentane-1,1-diol Chemical compound CCCCC(O)O UWJJYHHHVWZFEP-UHFFFAOYSA-N 0.000 description 1
- 150000003014 phosphoric acid esters Chemical class 0.000 description 1
- 230000036619 pore blockages Effects 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 208000008742 seborrheic dermatitis Diseases 0.000 description 1
- 230000005808 skin problem Effects 0.000 description 1
- 238000007447 staining method Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000012353 t test Methods 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/006—Antidandruff preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/008—Preparations for oily hair
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/12—Preparations containing hair conditioners
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
Abstract
The invention belongs to the field of cosmetics and discloses a composite micro-ecological oil control hair care composition and a hair care product. The composition comprises the following raw materials in parts by weight: 0.01 to 5 portions of inositol, 0.0001 to 3 portions of B vitamins, 0.01 to 10 portions of fructo-oligosaccharide and 0.0001 to 2 portions of tetrahydro-methyl pyrimidine carboxylic acid. The composite microecological oil-controlling hair-care composition has the obvious effect of balancing scalp water-oil balance, reduces the hair barrier loss, has good use feeling, and solves the problems of oily and not refreshing scalp, pruritus and desquamation, inflammation pimples, appearance collapse and lack of fluffy feeling and the like.
Description
Technical Field
The invention belongs to the field of cosmetics, and particularly relates to a composite micro-ecological oil control hair care composition and a hair care product.
Background
The scalp is a part of the skin and is also a source of life for a hair show. Structurally, scalp skin and skin of other parts such as the face are not obviously different, but hair follicles of the scalp are high in density, sebum secretion is vigorous, and meanwhile, a large number of sweat glands, exfoliated keratinocytes, sebum secreted lipids and mineral ions secreted by the sweat glands provide sufficient nutrient sources and proper growing environments for microorganisms, so that a unique scalp microecology is formed.
The microbiota of the normal scalp is mainly composed of bacteria and fungi, etc., mainly including staphylococcus, propionibacterium and malassezia, and these microorganisms do not generally cause scalp problems, and only when the scalp microecological balance is broken, such as hypersecretion of sebum, excessive proliferation of microorganisms, etc., scalp problems may occur. The balance of scalp microecology is mainly composed of three parts: sebum, flora and metabolic balance.
The healthy scalp does not have the phenomena of itch, greasiness, dryness and the like, and the sebum secretion of the scalp is moderate, so that the hair follicle mouth can not be blocked. However, at present, due to various internal and external factors, such as environmental pollution, emotional stress, unreasonable diet, genetic factors and the like, the following problems are often caused:
1) The water-oil balance of the scalp is disordered. Excessive sebum secretion from the scalp, resulting in greasy hair; scalp moisture is lost too quickly, resulting in a dry scalp desquamation.
2) The micro-ecological environment of the scalp is destroyed. Sebum is one of important nutrient sources of scalp microorganisms (mainly malassezia), harmful bacteria can be greatly proliferated when the scalp sebum is excessively secreted, beneficial bacteria are continuously reduced, and the scalp microecology is unbalanced.
3) After the scalp harmful bacteria are excessively proliferated, metabolites generated by sebum consumption can stimulate the scalp, and then an inflammatory reaction is generated, so that the problems of scalp cutin barrier damage (the increase of the percutaneous water loss rate), pore blockage, seborrheic dermatitis, hair follicle damage and alopecia caused by the hair follicle damage are caused. In addition, it may cause various discomforts such as greasy scalp, itching, desquamation, pimples on scalp, greasy hair feeling, not refreshing, collapse of hair appearance, and lack of fluffy feeling.
There are many skin care products on the market, but there are fewer oil control care products directed to the scalp, and these products are currently mainly focused on a single oil control efficacy, such as: adding alcohol, hamamelis or aluminum salt to astringe pores to control oil, adding kaolin or starch product to adsorb sebum to control oil, or adding surfactant to dissolve oil and fat to control oil. The scalp grease secretion is regulated by adding B vitamins, but the balance capability of the products on scalp microecology and the cutin barrier repair effect are limited, and uncomfortable symptoms such as greasy scalp, pruritus, inflammation and the like can still exist after the products are used.
Therefore, the invention develops a preferable composition by researching the sebum metabolic mechanism and the scalp barrier function of the scalp, and comprehensively solves the existing oily hair quality problems from the aspects of scalp oil control, microecological balance, cutin barrier repair, discomfort relieving and the like.
Disclosure of Invention
In view of the above-mentioned disadvantages of the prior art, it is an object of the present invention to provide a complex micro-ecological oil-controlling hair care composition and a hair care product, which solve the problems of the prior art.
To achieve the above objects and other related objects, the present invention is achieved by the following technical solutions.
One of the purposes of the invention is to provide a composite micro-ecological oil control hair care composition, which comprises the following raw materials in parts by weight:
according to the technical scheme of the application, the weight part of the inositol can be 0.01-2 parts, 1-3 parts or 2-5 parts. In certain preferred embodiments, 0.01 parts, 5 parts, 2 parts.
According to the technical scheme of the application, the weight portion of the B vitamins can be 0.01-3 parts, 2-6 parts or 5-10 parts. In certain preferred embodiments, 10 parts, 5.0001 parts, 1.21 parts, 1.3 parts.
According to the technical scheme of the application, the weight part of the fructo-oligosaccharide can be 0.003-4 parts, 2-7 parts or 5-10 parts. In certain preferred embodiments, 10 parts, 6 parts, 0.01 parts, and 1 part.
According to the technical scheme of the application, the weight part of the tetrahydro-methyl pyrimidine carboxylic acid can be 0.0001-0.015 part, also can be 0.01-1 part, also can be 0.5-2 parts. In certain preferred embodiments, 0.0001 parts, 2 parts, 1 part, and 0.3 part.
According to the technical scheme of the application, the composition comprises the following raw materials in parts by weight:
according to the technical scheme of the application, the fructo-oligosaccharide is prepared from sucrose as a raw material. The content of the fructo-oligosaccharide is 95-97 percent based on the total dry matter of the fructo-oligosaccharide. The content detection method of fructo-oligosaccharide is carried out according to GB/T23528-2009 fructo-oligosaccharide.
According to the technical scheme of the application, the total content of sucrose, fructose and glucose in the fructo-oligosaccharide is 3-5% based on the total dry matter of the fructo-oligosaccharide. The content detection method of sucrose, fructose and glucose in fructo-oligosaccharide is carried out according to GB 5009.8-2016 determination of fructose, glucose, sucrose, maltose and lactose in food safety national standard food.
According to the technical scheme of the application, the B vitamins are selected from one or two of vitamin B3 and vitamin B6.
Preferably, the mass ratio of the vitamin B3 to the vitamin B6 is (0.01-7): (0.0001 to 3).
More preferably, the mass ratio of the vitamin B3 to the vitamin B6 can be (0.01-1): (0.0001 to 3), and may be (0.5 to 1.5): (0.0001 to 3), and may be (1 to 3): (0.0001 to 3). In certain preferred embodiments, 7.
Preferably, the vitamin B3 is a derivative of vitamin B3.
More preferably, said vitamin B3 is niacinamide.
Preferably, the vitamin B6 is selected from one or more of pyridoxal, pyridoxine and pyridoxamine, and pharmaceutically acceptable salts thereof.
More preferably, the vitamin B6 is selected from one or more of pyridoxal hydrochloride, pyridoxine hydrochloride and pyridoxamine hydrochloride.
Further preferably, the vitamin B6 is one or more of pyridoxine hydrochloride, pyridoxal hydrochloride and pyridoxamine hydrochloride.
Vitamin B6 (Vitamin B6), also known as pyridoxine, includes pyridoxine, pyridoxal and pyridoxamine, which is present in the body in the form of phosphate esters and is a water-soluble Vitamin. The substances are unstable, are easy to damage by light or alkali, cannot resist high temperature and are inconvenient to apply to daily chemical products. Therefore, pyridoxine hydrochloride is preferably selected in the formula provided by the invention, so that the pyridoxine hydrochloride is more stable and convenient to store and use.
It is a second object of the present invention to provide a process for the preparation of a composition as described above, comprising the steps of:
the raw materials are mixed according to the parts by weight to obtain the composition.
It is a further object of the present invention to provide the use of a composition as described above in the preparation of a hair care product.
According to the technical scheme of the application, the hair care product comprises at least one of shampoo, essence, hair conditioner, hair care spray and hair mask, but is not limited to the shampoo, the essence, the hair conditioner, the hair care spray and the hair mask, and any form of the hair care product is within the protection scope of the application.
It is a fourth object of the present invention to provide a hair care product comprising a composition as described above.
According to the technical scheme, the addition amount of the composition is 0.1-27 wt% based on the total mass of the hair care product.
According to the technical scheme, the hair care product is selected from at least one of shampoo, essence, hair conditioner, hair care spray and hair mask.
Preferably, the hair care product is essence, and the addition amount of the composition is 2-6 wt% based on the total mass of the essence.
More preferably, the essence further comprises a thickener, a humectant, a preservative and water.
Further preferably, the thickener is selected from xanthan gum.
More preferably, the thickener is added in an amount of 0.01 to 2wt% based on the total mass of the essence.
Further preferably, the humectant is selected from butylene glycol.
More preferably, the addition amount of the humectant is 1-5 wt% based on the total mass of the essence.
Further preferably, the preservative is selected from one or more of p-hydroxyacetophenone, pentanediol and hexanediol.
More preferably, the preservative is added in an amount of 1-10 wt% based on the total mass of the essence.
The composition plays a role in regulating oil secretion through the vitamin B group, further balances the oil secretion capacity through inositol, and does not simply inhibit oil secretion, so that the symptoms of dry skinning pruritus and the like of people with low scalp humidity or dry skin are avoided; meanwhile, the microecological environment of the scalp is adjusted through fructo-oligosaccharide and tetrahydro-methyl pyrimidine carboxylic acid, so that adverse reactions such as greasiness, pruritus and inflammation caused by the disordered secretion of grease and the final oily skin due to the blockage of pores caused by the exuberant secretion of grease and the formation of byproducts harmful to the skin under the combined action of oxidation of excessive grease, malassezia and the like are avoided.
Compared with the prior art, the invention has the following beneficial effects:
the composite microecological oil-controlling hair-care composition has the obvious effect of balancing scalp water-oil balance, repairs the hair barrier, reduces the percutaneous water loss rate, has good use feeling, and solves the problems of oily and not refreshing scalp, pruritus and desquamation, inflammation pimples, appearance collapse and lack of fluffy feeling and the like.
Detailed Description
The embodiments of the present invention are described below with reference to specific embodiments, and other advantages and effects of the present invention will be readily apparent to those skilled in the art from the disclosure of the present invention.
Before the present embodiments are further described, it is to be understood that the scope of the invention is not to be limited to the specific embodiments described below; it is also to be understood that the terminology used in the examples is for the purpose of describing particular embodiments only, and is not intended to limit the scope of the present invention. Test methods in which specific conditions are not specified in the following examples are generally carried out under conventional conditions or under conditions recommended by the respective manufacturers.
When numerical ranges are given in the examples, it is understood that both endpoints of each of the numerical ranges and any number between the two endpoints are optional unless otherwise specified in the invention. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. In addition to the specific methods, devices, and materials used in the examples, the invention may be practiced using any method, device, and material that is similar or equivalent to the methods, devices, and materials described in examples herein, in addition to those described in prior art practice and the description herein.
TABLE 1 Source of raw materials and parameters
Examples 1 to 4
Referring to table 2, inositol, vitamin B3, vitamin B6, fructo-oligosaccharide, and tetrahydro-methyl pyrimidine carboxylic acid were mixed to obtain a complex micro-ecological oil control hair care composition.
Then mixing with water respectively to prepare essence, treating sebaceous gland cells (SZ 95) respectively, and evaluating the oil control effect by detecting the content of lipid droplets.
Meanwhile, a blank control group is set up and used as a comparison, and the blank control group comprises a maintenance culture solution. The maintenance medium was a DMEM high-glucose medium containing 1% Fetal Bovine Serum (FBS). Maintenance media are available from commercial sources.
And (3) detecting the content of lipid droplets: the lipid droplet content of the treated sebaceous gland cells (SZ 95) was examined by the oil red O staining method. Statistical analysis was performed using SPSS. Oil red O staining reference 1 (shige, wangting, influence of shortwave ultraviolet irradiation on sebum secretion from sebaceous gland cells [ J ]. Proceedings of the guangdong college of medicine, 2016,34 (4): 370-377).
TABLE 2 (wt%)
Table 3 shows the comparison of the lipid droplet content of the serum prepared by mixing the compositions obtained in examples 1 to 4 with water and the blank control group, which was analyzed statistically by the t-test.
TABLE 3 oil drop synthetic oil Red O staining results
Note: * P <0.05, P <0.01.
Sebaceous gland cells can be combined into a large amount of grease and secreted outside the cells in the form of grease droplets, so that the cell function is influenced, various skin problems are caused, and the amount of the grease droplets is a main index for measuring the oil control degree.
As can be seen from table 3, lipid droplet synthesis was significantly reduced after the cells were treated with the compositions of examples 1-4 compared to the blank control group (P < 0.05); in particular example 4, lipid droplet content was very significantly lower than that of the blank control (P < 0.01). The compositions of the present invention all have oil control effects.
Application example
The composition obtained in example 4 is used as a matrix and is compounded with other active substances to prepare the no-wash scalp essence. Meanwhile, comparative examples 1 to 8 are set up to investigate the oil control and micro-ecological effects of the composition. Comprises the following steps:
the formulations of the leave-on hair rinses of comparative examples 1 to 8 are given in Table 4.
TABLE 4 ingredient formulation Table (wt%)
Experimental groups and subjects: the experiment recruited 9 groups of 30 subjects each, aged 22 to 57 years, meeting the subject volunteer enrollment criteria. A total of 309 subjects (79 men and 230 women) completed the experiment, the number of people in each group was not less than 30, the statistical analysis requirements were met, and the experimental groups are shown in Table 5.
TABLE 5
Experimental treatment: the subject keeps the conventional washing and caring process, and uses the washing-free scalp essence 1 time per day, and when in use, the washing-free scalp essence is uniformly applied to the scalp, and is fully massaged for 1-5 minutes until being absorbed, without washing. Subjects underwent instrumental testing and self-assessment before the start of the experiment and at the end of the experiment (after 4 weeks), respectively.
And (3) analyzing an experimental result: the experimental data were statistically analyzed using SPSS. And comparing the same washing-free scalp essence before and after use, and adopting a paired t test or a two-correlation sample rank sum test according to whether the net change value is in accordance with normal distribution.
Net change = post product use measurement-pre product use base measurement
1. Investigation of oil control effect
By using
The DUAL MPA 580 test instrument measures the oil content of the scalp of each subject. The results of the oil content of the scalp are shown in table 6.
2. Barrier repair investigation
The scalp of each subject was tested for trans-epidermal water loss (TEWL) using a Tewameter TM 300 test instrument. The results of the transepidermal water loss are shown in Table 7.
3. Alleviating discomfort inspection
The subjects evaluated themselves. The test method comprises the following steps: the questionnaire survey form is adopted to allow the subject to score 5 sensory indexes such as dandruff removal, itching relieving, scalp pimple reduction, and hair refreshing and fluffy feeling. The score 1 was completely ineffective, the score 3 was relatively ineffective, the score 5 was general, the score 7 was relatively effective, and the score 9 was very effective. The statistical results are shown in Table 8.
TABLE 6 oil content of scalp (ug/cm)2)
Note: * P <0.05, P <0.01.
As can be seen from table 6, the average net change value of the oil content of the scalp after 4 weeks using the leave-on essence containing the composition of the present invention is minimal, indicating that the composition of the present invention can regulate the oil secretion of the scalp and achieve the balanced water-oil secretion.
TABLE 7 trans-epidermal water loss rate TEWL (g/cm)2.h)
| Group of | Base value | 4 week test value | Mean net change value |
| First group | 11.67±3.86 | 11.37±3.72 | -0.31 |
| Second group | 11.26±3.31 | 11.07±3.89 | -0.19 |
| Third group | 13.56±5.18 | 11.05±4.40** | -2.51 |
| Fourth group | 13.66±6.08 | 11.41±3.91* | -2.25 |
| Fifth group | 13.36±4.74 | 10.86±4.61** | -2.50 |
| Sixth group | 12.26±5.41 | 11.73±4.86 | -0.53 |
| Seventh group | 12.63±5.13 | 12.48±5.61 | -0.16 |
| Eighth group | 12.55±4.27 | 10.49±3.37* | -2.07 |
| Ninth group | 12.94±4.84 | 10.21±3.30** | -2.73 |
Note: * P <0.05, P <0.01.
As can be seen from table 7, the average net change value of the transepidermal water loss rate of the scalp after 4 weeks using the leave-on essence containing the composition of the present invention is minimal, which indicates that the composition of the present invention can regulate the oil secretion of the scalp and realize the balanced secretion of water and oil.
TABLE 8 subject self-rating questionnaire results (score 9 for each sensory index)
As is clear from table 8, after using the leave-on essence containing the composition of the present invention for 4 weeks, the subjects felt less dandruff, reduced itching of the head, reduced pimples of the scalp, a clean, non-greasy scalp, and a fluffy hair feel as a whole.
Comprehensively, the compound micro-ecological oil control and hair care composition disclosed by the invention is compounded by inositol, B vitamins, fructo-oligosaccharide and tetrahydro-methyl pyrimidine carboxylic acid, so that the problems of excessive sebum secretion of scalp, greasy hair, quick water loss and desquamation due to drying can be solved, and the water-oil balance of scalp can be regulated; the composition can inhibit harmful bacteria and increase beneficial bacteria, thereby reducing the hair barrier loss; after the composition is used by a subject, the composition has good use feeling, and the problems of greasy and not refreshing scalp, pruritus and desquamation, inflammatory pimple, collapse of appearance and lack of fluffy feeling and the like are solved.
The foregoing embodiments are merely illustrative of the principles and utilities of the present invention and are not intended to limit the invention. Any person skilled in the art can modify or change the above-mentioned embodiments without departing from the spirit and scope of the present invention. Accordingly, it is intended that all equivalent modifications or changes which can be made by those skilled in the art without departing from the spirit and technical spirit of the present invention be covered by the claims of the present invention.
Claims (10)
1. The composite micro-ecological oil control hair care composition is characterized by comprising the following raw materials in parts by weight:
2. the composition of claim 1, wherein the B vitamins are selected from one or two of vitamin B3, vitamin B6;
and/or, the content of the fructo-oligosaccharide is 95-97 percent based on the total dry matter of the fructo-oligosaccharide.
3. The composition according to claim 2, wherein the mass ratio of vitamin B3 to vitamin B6 is (0.01-7): (0.0001 to 3).
4. The composition of claim 2, wherein said vitamin B3 is selected from the group consisting of vitamin B3 and derivatives thereof; and/or, the vitamin B6 is selected from one or more of pyridoxal, pyridoxine and pyridoxamine and pharmaceutically acceptable salts thereof.
5. The composition of claim 4, wherein said vitamin B3 is niacinamide;
and/or the vitamin B6 is selected from one or more of pyridoxine hydrochloride, pyridoxal hydrochloride and pyridoxamine hydrochloride.
6. A process for preparing a composition as claimed in any one of claims 1 to 5, comprising the steps of:
the raw materials are mixed according to the parts by weight to obtain the composition.
7. Use of a composition according to any of claims 1 to 5 for the preparation of a hair care product.
8. The use according to claim 7, wherein the hair care product is selected from at least one of a shampoo, a serum, a conditioner, a hair mask, and a hair spray.
9. A hair care product comprising the composition according to any one of claims 1 to 5.
10. The hair care product according to claim 9, wherein the composition is added in an amount of 0.1 to 27 wt.%, based on the total mass of the hair care product.
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