CN1878531A - Improved cosmetic composition comprising vitamin b3, vitamin b6 and an organic acid - Google Patents
Improved cosmetic composition comprising vitamin b3, vitamin b6 and an organic acid Download PDFInfo
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- CN1878531A CN1878531A CNA2004800327179A CN200480032717A CN1878531A CN 1878531 A CN1878531 A CN 1878531A CN A2004800327179 A CNA2004800327179 A CN A2004800327179A CN 200480032717 A CN200480032717 A CN 200480032717A CN 1878531 A CN1878531 A CN 1878531A
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Abstract
A cosmetic composition is provided comprising vitamin B<SUB>6</SUB>, vitamin B<SUB>3 </SUB>and an organic acid. The components of the composition interact synergistically to enhance skin lightening.
Description
Technical field:
The present invention relates to the collaborative glossy compositions of skin that improves of a kind of energy.The invention particularly relates to a kind of compositions that the glossy active component of skin is used in combination that will be suitable for improving.
Background and prior art:
Melanin is the black pigment of hair and skin, and it is obtained from amino acid tyrosine is synthetic by melanosome.Melanosome is the organelle that is present in the cell type melanocyte of corium and epithelium intersection, and tyrosine is subjected to the effect of tryrosinase, and it is the committed step during melanin forms.Reported inhibitor such as the hydroquinone and the derivant thereof of tryrosinase, kojic acid, catechol, the sulfydryl amine, 'alpha '-hydroxy acids and other materials are used for cosmetic composition and regulate skin pigment.
IN182012 (Hindustan lever Ltd., 1994) discloses and has a kind ofly contained dicarboxylic acids and ascorbic acid can be accepted to be suitable for being applied topically to the cooperative compositions of human skin in the carrier at cosmetics.It has also been mentioned and can also use other brightening agents such as nicotiamide and/or opacifier (inorganic and/or organic).
In cosmetic composition, use 'alpha '-hydroxy acids to bring kind of a benefit, as improve texture, improve smoothness to skin, compactness, moisture, at U.S.Pat.No.5, existing report in 658,580 (CHANEL, INC, 1997).U.S.Pat.No.5,262,153 (Kabushiki, 1993) disclose lactic acid and derivant can be used as useful skin whitener, thus it can form the formation of inhibition melanin by restraint of tyrosinase.
Melanin in melanosome from monomer be synthesized (polymerization) and be transferred near keratinocyte.Keratinocyte division and differentiation are transferred to skin surface to melanosome.The intensity of skin color (intenskity) and melanic quantity, size, content, distribution, the formation of melanosome and to transfer to Keratinocytic speed directly related.
Also some methods is used nicotinic acid/nicotiamide or other skin lightening agent, it is believed that they can control the dispersion or the restraint of tyrosinase of melanosome.
The suitable mixture that IN144276 (Hindustan lever Ltd., 1975) discloses the UV absorbent of nicotiamide and absorption 290nm-360nmUV scope is used in combination.IN169917 (Hindustan lever Ltd., 1989) discloses the use silicone compounds and has been used in combination the collaborative skin gloss that improves with nicotiamide and opacifier.
The opacifier that is generally used in the skin gloss enhancing composition keeps the colour of skin by preventing the colour of skin deepening that ultraviolet light (UV) causes.Opacifier is the material of the ultraviolet light of the wavelength that can cause skin tanning and deepening injected of a kind of absorption.
Vitamin B6 claims pyridoxol again, and is closely related with water-soluble substances example hydrochloric acid pyridoxol, 2-methyl-3-hydroxy-4-formyl-5-hydroxymethylpyridine. and pyridoxamine on form and function.Additional pyridoxol can be used for solving the various skin problem, comprises scurf, eczema, dermatitis and psoriasis.It is the active component of a lot of anti-aging preparatons.JP04009325 (SUNSTAR INC, 1992) a kind of beauty treatment whitening cosmetic is disclosed, it passes through the mycelia culture thing with Ganoderma (Ganoderma lucidum Karst), and/or is selected from one or more extract mixing acquisitions as active component of ascorbic acid, retinol, pyridoxol, pantothenic acid, tocopherol, their salt and derivant.JP60188306 (Shiseido, 1985) discloses a kind of cosmetic composition, and it contains the pyridoxol or derivatives thereof and is used in combination the whitening effect that can improve enhancing skin significantly with ascorbic acid.
US5833998 (P ﹠amp; G, 1998) disclose a kind of topical composition that is used to regulate the greasy and/or bright looking of skin, it contains the active substance that one or more are selected from nicotiamide, pyridoxol, pantothenylol and pantothenic acid in acceptable cosmetics carrier for described active substance.
But prior art does not all have the collaborative cosmetic compositions that instruction contains vitamin B3, vitamin B6 and any monobasic, binary or polybasic carboxylic acid or phenolic acid to improve skin gloss or reduce cutaneous pigmentation.
One object of the present invention is to provide a kind of collaborative cosmetic compositions, and it contains vitamin B6, vitamin B3 and any monobasic, binary or polybasic carboxylic acid or phenolic acid, and it can strengthen skin gloss significantly.
Another object of the present invention is to provide a kind of collaborative cosmetic compositions, and it contains vitamin B6, vitamin B3 and any monobasic, binary or polybasic carboxylic acid or phenolic acid, and it can be for common skin and all effective by the destructive skin of UVR.
Said composition also can be used for the treatment of freckle, excessive painted skin, skin bubble point (blotchy skin), melasma, chloasma (cholasmas), senile plaque, black eye (dark circles) or the like.
The definition of invention
First aspect according to the present invention provides a kind of collaborative enhancing skin glossy compositions, and it contains:
I.0.05-10 the vitamin B6 or derivatives thereof of weight %;
The vitamin B3 or derivatives thereof of ii.0.05-10 weight %; With
Iii.0.05-20 weight % is selected from C
1-C
16At least a organic acid of monocarboxylic acid, dicarboxylic acids, polybasic carboxylic acid, phenolic acid and their ester/salt or other derivant.
According to a preferred aspect of the present invention, provide a kind of collaborative enhancing skin glossy compositions, it contains:
I.0.05-10 the vitamin B6 or derivatives thereof of weight %;
The vitamin B3 or derivatives thereof of ii.0.05-10 weight %;
Iii.0.05-20 weight % is selected from C
1-C
16Monocarboxylic acid, dicarboxylic acids, polybasic carboxylic acid, at least a organic acid in the phenolic acid and their ester/salt or other derivant; With
Iv.0.1 is at least a opacifier of 10 weight %; And/or
V. the active cleaning agent of cosmetics acceptable medium and/or 10-85%.
Especially preferred is 0.1 to 25 weight % of the cosmetics acceptable medium compositions that accounts for asymmetric solids and anion emulsifier, and wherein the pH of compositions is between 3 to 11, preferably between 3 to 8, more preferably between 3.5 to 6.
Detailed Description Of The Invention:
According to basic sides of the present invention, vitamin B6, vitamin B3 and at least a monobasic, binary or the polybasic carboxylic acid or phenolic acid/ester/salt or their derivant of being selected from are strengthened the glossy effect of skin in conjunction with acquisition.
Compositions of the present invention can be mixed with the type of keeping here or rinse-off products.The part of using among the present invention is kept the type compositions here can make various product forms.Comprising, but be not limited to washing liquid, mastic, gel, bar, aerosol, cleaning piece (wipes), facial film, ointment, pastel, mousse and cosmetics (, comprising foundation make-up) as solid, semisolid, liquid make-up.These product types can contain variety carrier, include but not limited to solution, aerosol, Emulsion (comprising Water-In-Oil and oil-in-water), gel, solid and liposome.They can be the rinse-off products forms, as soap-cake, abstergent, thin slice, liquid, gel or the like.Compositions of the present invention can be mixed with Pulvis Talci, liquid Pulvis Talci or muffin.
Strengthen the glossy vitamin of skin
Basic feature of the present invention is that the vitamin B6 or derivatives thereof combines existence with the vitamin B3 or derivatives thereof in the glossy compositions of enhancing skin of the present invention.Vitamin B6 just as defined here, is meant gang's water-soluble substances, comprises pyridoxine hydrochloride, 2-methyl-3-hydroxy-4-formyl-5-hydroxymethylpyridine. and pyridoxamine, and they are closely related on form and function.Vitamin B6 can obtain with the form of synthetic also can natural acquisition from animal food and plant.Liver, salmon, fish, Carnis Gallus domesticus, Petaso, egg, Carnis Sus domestica, beef, dry and cracked Semen Pisi sativi, dried bean, Fructus Musae, American Avocado Tree, Citrullus vulgaris, green Radix Brassicae rapae (turnipgreens), brussels sprout, Rhizoma Solani tuber osi, sweet Rhizoma Solani tuber osi, Radix Dauci Sativae, Semen Pisi sativi, chickpea, beer fermentation powder, Testa Tritici, Fructus Hordei Germinatus, kidney, heart, hami melon, Brassica oleracea L.var.capitata L., blackstrap molass and milk are some important sources of vitamin B6.Therefore can obtain from known natural or synthetic any source, perhaps obtain B6 from any commercial source.
Other important component are nicotiamide (niacinamide) or niacin amide (nicotinamide) in the compositions, and it forms the bioactive form that has of vitamin B3.The exemplary derivant of vitamin B3 comprises nicotinate, comprises the non-vasodilation ester of nicotinic acid, nicotinyl amino acids, the nicotine alcohol ester of carboxylic acid, nicotinic acid N-oxide and nicotinoyl amine n-oxide.
The addition of vitamin B6 is the 0.05-10 weight % of compositions, and preferably use amount is 0.1 to 5 weight %, more preferably the 0.5-2 weight % of cosmetic composition.The use amount of vitamin B3 is the 0.05-10 weight % of compositions, and preferably use amount is 0.1 to 5 weight %, more preferably 0.5 of cosmetic composition to 2 weight %.
Other can strengthen being added into that the glossy vitamin of skin can be favourable provides the collaborative glossy effect of skin that strengthens in the compositions.They comprise vitamin B12, vitamin C, vitamin E, vitamin A, vitamin D, vitamin K or their precursor/salt/ester/derivant.The mixture of vitamin also can be used for compositions of the present invention.Particularly preferred vitamin is vitamin B12, vitamin E and vitamin C.
Organic acid:
Organic acid can be selected from monobasic, binary polybasic carboxylic acid or phenolic acid and salt, ester or derivant.
Monocarboxylic acid can be substituted or not be substituted.It (is C that the monocarboxylic acid carbon chain lengths can reach 16
1-C
16Acid), more preferably reaching 14 (is C
1-C
14And most preferably to reach 12 (be C acid),
1-C
12Acid).Particularly preferred monocarboxylic acid have ascorbic acid or α-, β-or polyhydroxy acid comprises hydroxyacetic acid, lactic acid, 2-hydroxyl-sad, salicylic acid and/or its mixture.Particularly preferred beta-hydroxycarboxylic acids is lactic acid or its salt, as DL-Lactic acid ammonium salt..Particularly preferred beta-hydroxycarboxylic acids is a salicylic acid.
Be applicable to that dicarboxylic acids of the present invention can represent with following formula: HOOC-(C
xH
y)-COOH is C wherein
xH
yCan choose wantonly and be substituted, and x=0 to 20 and y=0 to 40.Particularly preferred dicarboxylic acids comprises Azelaic Acid, decanedioic acid, oxalic acid, succinic acid, fumaric acid.Polybasic carboxylic acid includes but not limited to citric acid.
Organic acid can also be vitamin acid, comprises ascorbic acid, tretinoin or pantothenic acid (pantethenoic acid).Organic acid can also comprise natural acid such as glycertenicacid and poly-glycerine acid.The acid of reducing sugar or non-reducing sugar also can be used as organic acid and uses.
Particularly preferred phenolic acid is selected from ferulic acid, salicylic acid, kojic acid.
Organic acid of the present invention is preferably water miscible.So-called " water solublity " is meant in the time of 20 ℃, and acid water solublity in every 100g water reaches 0.1g at least.
Strengthen skin gloss reagent:
The glossy reagent of other known enhancing skins comprises as hydroquinone and derivant (as arbutin, 4-hydroxyanisol, mequinol, HMBE, monobenzone etc.) thereof, retinol and derivant thereof (for example retinoic acid, tretinoin), resorcinol and derivant thereof (for example 4-alkyl-resorcin etc.), reservatol, ellagic acid, linoleic acid and alpha-lipoic acid can also use the natural glossy extract of enhancing skin and its mixture.
Opacifier:
Compositions of the present invention preferably includes the opacifier and/or the sunscreen (sun-block agent) of effective amount, to strengthen the cooperative effect that skin gloss improves compositions.Organic and inorganic opacifier/sunscreen or be used in combination them and all be applicable to this compositions.
Ultraviolet light is the principal element that causes colour of skin deepening.Therefore, in order to strengthen skin gloss, contain UVA in the compositions and/or the UVB opacifier is desirable.
Various traditional opacifier all is fit to be used in combination with the glossy compositions of enhancing skin of the present invention.Suitable opacifier comprises, para-amino benzoic acid, its salt and derivant (ethyl, isopropyl, glyceryl ester; ESCAROL 507); O-aminobenzoa (that is o-aminobenzoa; Methyl, base, phenyl, benzyl, phenylethyl, linalyl, terpinyl and cyclohexenyl group ester); Salicylate (amyl group, phenyl, benzyl, base, glyceryl and dipropylene glycol ester); Cinnamic acid derivative ( base and benzyl esters, α-phenyl cinnamonitrile; Butyl cinnamoyl pyruvate); Dihydroxycinnamic acid derivant (umbelliferone, methyl umbelliferone, methyl acetyl-umbelliferone); Trihydroxy cinnamic acid derivative (esculetin, methyl esculetin, daphnetin, and glucoside, Esculin and daphnin); Carbohydrate (diphenyl diethylene, stilbene); Dibenzalacetone and benzalacetophenone; Aphthol-sulfonic acids salt (beta naphthal-3,6-disulfonic acid and beta naphthal-6, the sodium salt of 8-disulfonic acid); Dihydroxy-naphthoic acid and salt thereof; Neighbour and parazon base disulfonate; Coumarin derivative (7-hydroxyl, 7-methyl, 3-phenyl); Diazole (2-acetyl group-3-bromo-indazole, phenyl benzoxazol, methyl naphtho- azoles, various aryl benzothiazoles); Quinine salt (disulfate, sulfate, chloride, oleate and tannate); Quinoline (oxinate, 2-phenylchinoline); Hydroxyl-or the benzophenone that replaces of methoxyl group; Uric acid and vilouric acids; Tannic acid and derivant thereof (for example, Hexaethyl ether); (butyl carbotol) (6-propyl group piperonyl) ether; Hydroquinone; Benzophenone (phenol, sulisobenzone, dioxybenzone, benzo resorcinol, 2,2 ', 4,4 '-the tetrahydroxy benzene ketone, 2,2 '-dihydroxy-4,4 '-the dimethyl benzene ketone, octabenzone); 4-isopropyl diphenyl formyl methane; Butyl-methoxy dibenzoyl methane; Etocrilene; With 4-isopropyl-two-benzoyl methane.
Wherein, preferred 2-ethylhexyl-p-methoxycinnamic acid ester; 4; 4 '-tert-butyl group methoxy dibenzoyl methylmethane, 2-hydroxyl-4-methoxybenzene ketone, octyldimethyl-para-amino benzoic acid; two galloyl trioleates; 2,2-dihydroxy-4-methoxybenzene ketone, ethyl-4-(two (hydroxypropyl)) Aminobenzoate; 2-ethylhexyl-2-cyano group-3; 3-diphenylacrylate ester, 2-Ethylhexyl salicylate, glyceryl-p-aminobenzoate; 3; 3,5-trimethylcyclohexyl salicylate, methyl 2-aminobenzoate; to dimethyl-amino benzoic Acid or Aminobenzoate; the 2-ethylhexyl-to dimethyl-amino-benzoate, 2-Phenylbenzimidazole-5-sulfonic acid, 2-(to dimethylaminophenyl)-5-sulfonic group benzo azoles acid (benzoxazoicacid) and composition thereof.
The preferred in the present invention opacifier that is used for compositions is 2-ethylhexyl-p-methoxycinnamic acid ester, PAROSOL 1789,2-hydroxyl-4-methoxybenzene ketone, octyldimethyl-para-amino benzoic acid and composition thereof.
The opacifier that can be used for compositions is preferably authorized the U.S.Pat.No.4937370 of Sabatelli June 26 nineteen ninety, authorized disclosed opacifier among the U.S.Pat.No.4999186 of Sabatelli and Spirnak on March 12nd, 1991, they are all introduced with list of references at this.Wherein disclosed opacifier has two different chromophore parts in individual molecule, show different ultraviolet radiation absorption spectrums.One of them chromophore part mainly absorbs in the UVB radiation areas and another has strong absorption in the UVA radiation areas.
Answer the opacifier of safe in utilization and effective dose in the compositions of the present invention.Compositions preferably contains has an appointment 0.1% to about 10%, more preferably one or more opacifiers of from about 0.1% to about 5%.
Useful inorganic sunscreen or sunscreen include but not limited to, zinc oxide, ferrum oxide, tripoli are as pyrogenic silica and titanium dioxide.
No matter in two kinds of forms of superfine titanic oxide which kind of, promptly water dispersible titanium dioxide and can oily dispersive titanium dioxide all is specially adapted to the present invention.
Water dispersible titanium dioxide is superfine titanic oxide, and its microgranule has not covered or covered the material that can promote the microparticle surfaces water-wet behavior.Examples of substances comprises aluminium oxide and aluminium silicate like this.
Can oily dispersive titanium dioxide be superfine titanic oxide, its microparticle surfaces have showed hydrophobic character, for this purpose, and can be at its surface coverage metallic soap, as aluminium stearate, Aluminum trilaurate or zinc stearate or organosilicone compounds.
Be applied on the skin by mixture part, just can obtain the collaborative effect that protection skin is avoided the evil of UV-A and uv b radiation that strengthens inorganic sunscreen or sunscreen and/or organic opacifier.
The total amount that is used for the inorganic sunscreen of compositions of the present invention or sunscreen is preferably the 0.1-5 weight % of compositions.
The cosmetics acceptable medium
Compositions of the present invention also contains the cosmetics acceptable medium, as the carrier of other materials that occur in diluent, dispersant or the compositions, thereby makes the dispersion that promotes them when compositions is used for skin.
Term " cosmetics acceptable medium " is meant one or more compatible solid, liquid filler materials mutually, diluent, supplement etc., and they are acceptable on cosmetics.The term of Shi Yonging " compatible " is meant that the component of compositions of the present invention can blend reach basic function of the present invention herein, and under common service condition, does not significantly weaken the effect of compositions thereby they react to each other.The type that is used for carrier of the present invention is decided with the type of required product.
Medium outside dewatering can comprise liquid state or solid lubricant, oil, silicone oil, solvent, wetting agent, thickening agent, emulsifying agent, sheds agent and powder.In the medium of these types each can also can be mixed use by one or more media separately, and described mixture can be emulsion form (O/W, W/O or W/O/W).
Lubricant and oil, include but not limited to stearyl alcohol, single ricinoleic acid glyceride, butter, hexadecanol, the isostearic acid isopropyl ester, stearic acid, the Palmic acid isobutyl ester, stearic iso-16 alkyl esters, oleyl alcohol, isopropyl laurate, lauric acid hexyl ester, decyl oleate, octadecane-2-alcohol, 2-Methylpentadecane alcohol, EICOSANOL, tadenan, cetyl palmitate, silicone oil such as dimethyl polysiloxane, n-butyl sebacate, isopropyl myristate, isopropyl palmitate, isopropyl stearate, butyl stearate, Polyethylene Glycol, 2,2'-ethylenedioxybis(ethanol)., lanoline, cupu oil, Semen Maydis oil, Oleum Gossypii semen, olive oil, palm-kernel oil, Oleum Brassicae campestris, safflower oil, Radix Oenotherae erythrosepalae oil, soybean oil, Oleum Helianthi, American Avocado Tree oil, Oleum sesami, Oleum Cocois, Oleum Arachidis hypogaeae semen, Oleum Ricini, Acetylated lanolin alcohols., vaseline, mineral oil, the tetradecanoic acid butyl ester, isostearic acid, Palmic acid, the linoleic acid isopropyl ester, the dodecyl lactate ester, lactic acid tetradecane ester, decyl oleate, tetradecanoic acid 14 esters; Or the like.
The nonrestrictive example of silicone oil comprises polydimethylsiloxane, annular dimethyl polysiloxane, poly dimethyl silanol and composition thereof.
Water is preferred solvent.The example of appropriate organic solvent comprises: propylene glycol, Polyethylene Glycol, polypropylene glycol, glycerol, 1,2,4-butantriol, 1,2,6-hexanetriol, ethanol, isopropyl alcohol, sorbitol ester, butanediol, acetone, ethylene glycol monomethyl ether, diethylene glycol single-butyl ether, TC and composition thereof.
Wetting agent can be selected from glycerol, diglycerol, triglycerin, polyglycereol, ethoxylation and propoxylated glycerol polypropylene glycol, Polyethylene Glycol, ethylene glycol, diethylene glycol, 2,2'-ethylenedioxybis(ethanol)., propylene glycol, dipropylene glycol, hexanediol, 1,3-butanediol, 1, the 4-butanediol.In these polyhydric alcohol, propylene glycol and dipropylene glycol are preferred.
Powder, as Chalk, Talcum, bleaching earth, Kaolin, starch, natural gum, silica sol sodium polyacrylate, the aluminium-magnesium silicate of tetraalkyl and/or trialkyl aryl Montmorillonitum, chemical modification, organically-modified montmorillonitic clay, aluminium hydrosilicate, pyrogenic silica, CVP Carbopol ETD2050, sodium carboxymethyl cellulose and ethylene glycol monostearate can be selected for use.
The example of suitable thickening comprises polymer viscosifier such as acrylate/C10-30 alkyl acrylate cross-linked polymer, polyacrylamide, cationic polymer, natural gum (as xanthan gum, guar gum), and cellulose derivative (as hydroxyethyl-cellulose, hydroxypropyl cellulose).
Shed agent and include but not limited to propane, butane, iso-butane, dimethyl ether, carbon dioxide and nitrous oxide.
When preparation medium or emulsion mixture, can choose wantonly and use cationic and/or anionic emulsifier, but preferred the use.
Suitable anionic emulsifier can be selected from the fatty acid amides of alkyl sulfate/ester, aralkyl sulfate/ester, alkyl ethoxy ether sulfate/ester, alkylaryl sulfonate/ester, dialkyl succinylsuccinate salt/ester, alkylthio succinate/ester, N-alkoxyl (alkoyl) sarcosinate/ester, isethionate/ester, N-acyl taurine salt/ester, methylamino esilate/ester, and is used in combination them.For example, can select the salt of sulfuric acid monoester or phosphate monoester, C
12-18Fatty acid, C
12-18Aliphatic alcohol, C
12-18Acyl group ethylenehydrinsulfonic acid, C
12-18Alkyl sulfonic acid or C
12-18The salt of acylamino acid.The non-limitative example of anionic surfactant comprises phosphate ester such as polyoxyethylene (10) lauryl ether sodium phosphate, DEA hexadecanyl phosphate, potassium cetyl phosphate, phosphorous organic derivative such as Phosphation oleyl ether (10 ethylene oxide), sodium lauryl sulfate and spermaceti/stearyl sodium sulfate.
The non-limitative example of suitable nonionic emulsifier has aliphatic alcohol, glycerine monofatty ester, glyceryl monostearate and two glyceryl monostearates, the ethoxylate of fatty acid and propoxylate, as polyoxyethylene (100)-stearic acid propylene glycol monostearate, sorbitan fatty acid esters such as sorbitan monostearate, polyoxyethylene (20) sorbitan monostearate, the aliphatic alcohol of ethoxylation such as polyoxyethylene (21) stearoyl ether, polyoxyethylene (2) stearoyl ether, polyoxyethylene (10) castor oil hydrogenated, Marlamid such as cocoyl diethyl alcohol amide and lauramide DEA, the block copolymer of block polymer such as expoxy propane and oxirane, alkyl poly glucoside, sucrose and glucose ester with and derivant such as sucrose distearate and sucrose stearate and polyglyceryl fatty acid ester.Other nonionic emulsifier comprise the alkyl phenol of ethoxylation, as polyoxyethylene (10) nonylplenyl ether, the fatty acid of ethoxylation such as Polyethylene Glycol (10 oxirane) monostearate, ethoxylated fatty acid such as polyoxyethylene (5) glycerol monostearate, ethoxylated fatty acid ester and oil, as glyceride such as lanoline radical derivative such as Wool wax alcohols,ethoxylated, the fatty acid of propoxyl group and ethoxylation, alcohol or alkyl phenol such as polyoxyethylene (10) polyoxypropylene (4) cetyl ether and protein-based surfactant such as the single isostearate of polyoxyethylene (25) glycerol list pyroglutamic acid (pyoglutamic).Nonionic emulsifier preferably include following separately or be used in combination: ethoxylated alkyl ether (trade mark is Brij); Sorbitan ester (trade mark is Span); Ethoxylation dehydrated sorbitol ester (trade mark is Tween); Ethoxylated fatty acid ester (trade mark is Myrj); Aliphatic alcohol; The ethoxylized fatty alcohol of glycerol; And fatty acid.
The asymmetric granule of suitable solid comprises the fatty acid crystal, Muscovitum, Talcum, clay and composition thereof.Preferred solid particle is selected from the fatty acid crystal, and fatty acid wherein contains 12-22 carbon atom, because they cheaply and aesthetically can be accepted.Most preferred fatty acid is a stearic acid.Its accurate content depends on the character of other compositions in final composition and the compositions.
The cleaning agent active substance:
The glossy compositions of enhancing skin of the present invention can also the rinse-off products form provide, and is used for the individual and cleans.The cleaning agent active substance is the preferred ingredient in the compositions and has been selected from the soap active substance or non-soap active substance.Cleaning agent can be selected from anionic, nonionic, cationic, both sexes or amphion active substance.These active substances are disclosed in standard detergent textbook for example " Surface Active Agents ", and Schwartz and Perry compile, the first volume and " Surface Active Agents and Detergents " Schwartz, and Perry and Berch compile, second volume.
Term soap is meant carboxylic acid soap.This soap can derive from normally used any triglyceride in the Soap Factory, and the carboxylic acid ion in the soap contains 8 to 22 carbon atoms as a result.
For the soap that contains 18 carbon atoms, the common content of simultaneous sodium cation is about 8% weight.Other useful cationes can be for example zinc, potassium, magnesium, alkylammonium and aluminum.
Soap can be by obtaining fat and/or fatty acid saponification.Normally used fat or oil can be as Adeps Bovis seu Bubali, oleostearin, Petiolus Trachycarpi oil, palm stearin, soybean oil, fish oil, Oleum Ricini, Testa oryzae oil, sunflower oil, Oleum Cocois, babassu oil, palm-kernel oil or the like in the Soap Factory.Fatty acid is made by the oil/fat that is selected from Cortex cocois radicis, Testa oryzae, Semen arachidis hypogaeae, Adeps Bovis seu Bubali, Petiolus Trachycarpi, palm kernel, cotton seed, Semen sojae atricolor, Semen Ricini or the like in the said process.Fatty acid soaps can synthesize preparation (for example passing through the oxidation of oil or the Fischer-tropsch process hydrogenation of carbon monoxide).Resinic acid can be used as tall oil.Cycloalkyl acid also is suitable.
Tallow fatty acids can and generally contain the 1-8% tetradecanoic acid of having an appointment, about 21-32% Palmic acid, about 14-31% stearic acid, about 0-4% hexadecenoic acid, about 36-50% oleic acid and about 0-5% linoleic acid from multiple animal origin acquisition.A kind of typical distribution is 2.5% tetradecanoic acid, 29% Palmic acid, 23% stearic acid, 2% hexadecenoic acid, 41.5% oleic acid and 3% linoleic acid.Other similar mixture are as being also included within wherein from Petiolus Trachycarpi oil with from the mixture of various animal Adeps Bovis seu Bubalis and Adeps Sus domestica.
Oleum Cocois is meant that having carbon chain length distribution is about 8% C
8, 7% C
10, 48% C
12, 17% C
14, 8% C
16, 2% C
18, 7% oleic acid and 2% linoleic acid (it is saturated that listed the first six planted fatty acid) fatty acid mixt.Other sources have a similar carbon chain length distribution, as palm-kernel oil and babassu core oil, just be included among the term Oleum Cocois.
Optional cosmetic composition
Compositions of the present invention can contain other optional members widely.CTFA cosmetic composition handbook (CTFA Cosmetic Ingredient Handbook) second edition, compiled in 1992, introduce in full as reference at this, it has put down in writing normally used nonrestrictive widely cosmetics and ingredient in the skin care industry, and they all are applicable to compositions of the present invention.Example comprises: antioxidant, binding agent, bio-additive, buffer agent, coloring agent, thickening agent, polymer, astringent, aromatic, wetting agent, opacifiers, pH regulator agent, antiseptic, natural extract, essential oil, skin sensitivity agent (skin sensates), skin slipping agent, and skin treatment agent.
The present invention further specifies by following non-limiting example.
Embodiment 1:
Each composition of being put down in writing in the table 1 is mixed with 7 kinds of contrast preparatons (F1 is to F7) and a kind of according to preparaton of the present invention (F8).
Described each preparaton is used to test their glossy effects of enhancing skin for the group of being made up of 30 volunteers with the colour of skin.Write down the initial colour of skin.By well-trained operator above-mentioned preparaton is applied to experimenter's palm forearm in preassigned position.Each administration interval 2 hours is used 5 times these preparatons every day in each position, forearm cleans after can only and using for the last time before using for the first time, uses 40 variations that the back writes down the colour of skin of taking second place.The difference of the position by relatively using preparaton and the colour of skin around it is estimated the variation of classification with evaluate color.Difference between substrate itself (contrast medium) and the site of administration can be used for indicating the effect of preparaton, and minus skin gloss strengthens value representation and strengthens and positive value representation deepening.
Table 1
| The % composition weight | ||||||||
| Composition | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 |
| Stearic acid | 18.00 | 18.00 | 18.00 | 18.00 | 18.00 | 18.00 | 18.00 | 18.00 |
| Hexadecanol | 0.40 | 0.40 | 0.40 | 0.40 | 0.40 | 0.40 | 0.40 | 0.40 |
| Glyceryl monostearate | 0.60 | 0.60 | 0.60 | 0.60 | 0.60 | 0.60 | 0.60 | 0.60 |
| Silicone oil | 0.50 | 0.50 | 0.50 | 0.50 | 0.50 | 0.50 | 0.50 | 0.50 |
| Cetearyl sodium sulfate | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 |
| The mixture of sorbitan ester and ethoxylated fatty acid ester | 1.5 | 1.5 | 1.5 | 1.5 | 1.5 | 1.5 | 1.5 | 1.5 |
| Alkyl acrylate cross-linked polymer | 0.15 | 0.15 | 0.15 | 0.15 | 0.15 | 0.15 | 0.15 | 0.15 |
| Polyhydroxy-alcohol | 10.00 | 10.00 | 10.00 | 10.00 | 10.00 | 10.00 | 10.00 | 10.00 |
| Antiseptic | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 |
| EDTA | 0.04 | 0.04 | 0.04 | 0.04 | 0.04 | 0.04 | 0.04 | 0.04 |
| Vitamin B3 | - | 1.00 | - | - | 1.00 | 1.00 | - | 1.00 |
| Vitamin B6 | - | - | 1.00 | - | 1.00 | - | 1.00 | 1.00 |
| Decanedioic acid | - | - | - | 0.75 | - | 0.75 | 0.75 | 0.75 |
| Water | To 100 | |||||||
Following table 2 data presented is the meansigma methods of skin gloss enhancing value, promptly by the mean value calculation of all volunteers' difference value and get.
Table 2
| F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 | |
| Skin gloss reinforced effects | 0.0 | -0.09 | -0.03 | -0.12 | -0.02 | -0.16 | -0.11 | -0.28 |
The data show of table 2 only is used in combination vitamin B3 and vitamin B6 and carboxylic acid (F8) can obtain the collaborative glossy effect of skin that strengthens, and singly is used in combination (F6 or F7) or two kinds of vitamin with carboxylic acid with a kind of vitamin and combines (F5) use and do not significantly improve than the independent use (F2, F3 or F4) of composition.
Embodiment 2:
As shown in table 3, each composition is mixed with 3 kinds of contrast preparatons (F9 is to F11) and a kind of according to preparaton of the present invention (F12).
Preparaton is tested by the group that 30 volunteers with the colour of skin form for strengthening the glossy effect of skin.Write down the initial colour of skin.By well-trained operator above-mentioned preparaton is applied to experimenter's palm forearm in preassigned position.Each administration interval 2 hours is used 5 times these preparatons every day in each position, forearm cleans after can only and using for the last time before using for the first time, uses 25 variations that the back writes down the colour of skin of taking second place.The difference of the position by relatively using preparaton and the colour of skin around it is estimated the variation of classification with evaluate color.Difference between substrate itself (contrast medium) and the site of administration can be used for indicating the effect of preparaton, and minus skin gloss strengthens that value representation strengthens and on the occasion of the expression deepening.
Table 3
| The % composition weight | ||||
| Composition | F9 | F10 | F11 | F12 |
| Stearic acid | 18.00 | 18.00 | 18.00 | 18.00 |
| Hexadecanol | 0.40 | 0.40 | 0.40 | 0.40 |
| Glyceryl monostearate | 0.60 | 0.60 | 0.60 | 0.60 |
| Silicone oil | 0.50 | 0.50 | 0.50 | 0.50 |
| Cetearyl sodium sulfate | 1.0 | 1.0 | 1.0 | 1.0 |
| The mixture of sorbitan ester and ethoxylated fatty acid ester | 1.5 | 1.5 | 1.5 | 1.5 |
| Alkyl acrylate cross-linked polymer | 0.15 | 0.15 | 0.15 | 0.15 |
| Polyhydroxy-alcohol | 10.00 | 10.00 | 10.00 | 10.00 |
| Antiseptic | 0.5 | 0.5 | 0.5 | 0.5 |
| EDTA | 0.04 | 0.04 | 0.04 | 0.04 |
| Vitamin B3 | - | 1.00 | - | 1.00 |
| Vitamin B6 | - | - | 1.00 | 1.00 |
| Decanedioic acid | - | 1.00 | 1.00 | 1.00 |
| Water | To 100 | |||
Following table 4 data presented is the meansigma methods of skin gloss enhancing value, promptly by the mean value calculation of all volunteers' direct difference value and get.
Table 4
| F9 | F10 | F11 | F12 | |
| Skin gloss reinforced effects | 0.0 | -0.03 | -0.04 | -0.11 |
The data show of table 4 only is used in combination vitamin B3 and vitamin B6 and other acid ingredients (ferulic acid) and can obtains collaboratively to strengthen the glossy effect of skin, and this acid is used in combination separately with any vitamin and does not observe this effect.
Therefore, the invention provides a kind of glossy compositions of collaborative enhancing skin that vitamin B3 and B6 are used in combination with carboxylic acid that contains.
Claims (19)
1. can work in coordination with the glossy compositions of raising skin for one kind, it contains:
I.0.05-10 the vitamin B of weight %
6Or derivatives thereof;
The vitamin B of ii.0.05-10 weight %
3Or derivatives thereof; And
Iii.0.05-20 weight % is selected from C
1-C
16Monocarboxylic acid, dicarboxylic acids, polybasic carboxylic acid, at least a organic acid in the phenolic acid and their ester/salt or other derivant.
2. can work in coordination with described in the claim 1 improved the glossy compositions of skin, and it also contains at least a opacifier of 0.1 to 10 weight %.
3. can work in coordination with described in the claim 2 improved the glossy compositions of skin, and wherein said opacifier is organic or inorganic or their combination.
4. the described energy of aforementioned arbitrary claim is worked in coordination with and is improved the glossy compositions of skin, also contains the cleaning agent active substance of 10 to 85 weight %.
5. can work in coordination with described in the claim 4 improved the glossy compositions of skin, and wherein said cleaning agent active substance is anion active material, nonionic active substance, cationic active material, amphiprotic activity material, amphion active substance or their mixture.
6. the collaborative glossy compositions of skin that improves of the described energy of aforementioned arbitrary claim, it also contains the cosmetics acceptable medium.
7. can work in coordination with described in the claim 6 improved the glossy compositions of skin, and wherein said cosmetics acceptable medium contains solid-state asymmetric granule and the anion emulsifier of 0.1 to 25 weight % of composition weight.
8. the collaborative glossy compositions of skin that improves of the described energy of aforementioned arbitrary claim, wherein the pH of compositions is between 3 and 11, preferably between 3 and 8.
9. the collaborative glossy compositions of skin, the wherein vitamin B of improving of the described energy of aforementioned arbitrary claim
6Or derivatives thereof is selected from synthetic or natural material.
10. the collaborative glossy compositions of skin, the wherein vitamin B of improving of the described energy of aforementioned arbitrary claim
3Or derivatives thereof is selected from nicotiamide, niacin amide, and nicotinate, the non-vasodilation ester of nicotinic acid, nicotinyl amino acids, the nicotinyl alcohol ester of carboxylic acid, nicotinic acid N-oxide, the nicotinoyl amine n-oxide, and composition thereof.
11. the collaborative glossy compositions of skin that improves of the described energy of aforementioned arbitrary claim, wherein the addition of vitamin B6 or derivatives thereof is 0.1 to 5 weight % of compositions, preferred 0.5 to 2 weight %.
12. the collaborative glossy compositions of skin, the wherein vitamin B of improving of the described energy of aforementioned arbitrary claim
3The addition of or derivatives thereof is 0.1 to 5 weight % of compositions, preferred 0.5 to 2 weight %.
13. the collaborative glossy compositions of skin that improves of the described energy of aforementioned arbitrary claim, wherein organic acid comprises replacement or unsubstituted C
1-C
16Monocarboxylic acid.
14. can work in coordination with described in the claim 13 improved the glossy compositions of skin, the wherein C of Qu Daiing
1-C
16Monocarboxylic acid is an ascorbic acid, 'alpha '-hydroxy acids, beta-hydroxy acid, polyhydroxy acid or their mixture.
15. can work in coordination with described in the claim 14 improved the glossy compositions of skin, the wherein C of Qu Daiing
1-C
16Monocarboxylic acid is a hydroxyacetic acid, lactic acid, 2-Hydroxycaprylic acid, salicylic acid or their mixture.
16. the collaborative glossy compositions of skin that improves of the described energy of aforementioned arbitrary claim, wherein organic acid comprises the dicarboxylic acids of following formula representative: HOOC-(C
xH
y)-COOH, wherein C
xH
yCan choose wantonly and be substituted x=0 to 20, and y=0 to 40.
17. can work in coordination with described in the claim 16 improves the glossy compositions of skin, wherein dicarboxylic acids is Azelaic Acid, decanedioic acid, oxalic acid, succinic acid, fumaric acid or their mixture.
18. the collaborative glossy compositions of skin that improves of the described energy of aforementioned arbitrary claim, wherein organic acid comprises polybasic carboxylic acid, and it is a citric acid.
19. the collaborative glossy compositions of skin that improves of the described energy of aforementioned arbitrary claim, wherein organic acid comprises phenolic acid, and it is ferulic acid, salicylic acid, kojic acid or their mixture.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN1165MU2003 | 2003-11-06 | ||
| IN1165/MUM/2003 | 2003-11-06 | ||
| GB0404118.2 | 2004-02-25 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1878531A true CN1878531A (en) | 2006-12-13 |
| CN100591321C CN100591321C (en) | 2010-02-24 |
Family
ID=37510705
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200480032717A Expired - Lifetime CN100591321C (en) | 2003-11-06 | 2004-10-29 | Improved cosmetic composition comprising vitamin b3, vitamin b6 and an organic acid |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN100591321C (en) |
| ZA (1) | ZA200602583B (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103301054A (en) * | 2013-06-27 | 2013-09-18 | 安婕妤化妆品科技股份有限公司 | Collagen gel capable of moisturizing, revitalizing and nourishing as well as preparation method and application thereof |
| CN102125511B (en) * | 2010-01-19 | 2015-04-29 | 上海华银日用品有限公司 | Tendering, whitening and moisturizing cream and preparation method thereof |
| CN115252445A (en) * | 2022-07-14 | 2022-11-01 | 苏州猫尔科技有限公司 | Composite micro-ecological oil control hair care composition and hair care product |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1240224B (en) * | 1962-08-10 | 1967-05-11 | Merck Ag E | Process for stabilizing orotic acid in acidic, aqueous or aqueous-alcoholic, especially vitamin-containing, solution |
-
2004
- 2004-10-29 ZA ZA200602583A patent/ZA200602583B/en unknown
- 2004-10-29 CN CN200480032717A patent/CN100591321C/en not_active Expired - Lifetime
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102125511B (en) * | 2010-01-19 | 2015-04-29 | 上海华银日用品有限公司 | Tendering, whitening and moisturizing cream and preparation method thereof |
| CN103301054A (en) * | 2013-06-27 | 2013-09-18 | 安婕妤化妆品科技股份有限公司 | Collagen gel capable of moisturizing, revitalizing and nourishing as well as preparation method and application thereof |
| CN103301054B (en) * | 2013-06-27 | 2014-03-26 | 安婕妤化妆品科技股份有限公司 | Collagen gel capable of moisturizing, revitalizing and nourishing as well as preparation method and application thereof |
| CN115252445A (en) * | 2022-07-14 | 2022-11-01 | 苏州猫尔科技有限公司 | Composite micro-ecological oil control hair care composition and hair care product |
| CN115252445B (en) * | 2022-07-14 | 2024-03-05 | 苏州猫尔科技有限公司 | Composite microecological oil-control hair care composition and hair care product |
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200602583B (en) | 2007-06-27 |
| CN100591321C (en) | 2010-02-24 |
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