CN102088948A

CN102088948A - A method of lightening skin

Info

Publication number: CN102088948A
Application number: CN2009801268838A
Authority: CN
Inventors: J·P·巴斯卡尔; R·梅塔; R·拉贾戈帕尔; B·R·沙尔马; N·苏伦德拉
Original assignee: Unilever NV
Current assignee: Unilever NV
Priority date: 2008-07-10
Filing date: 2009-06-22
Publication date: 2011-06-08
Also published as: JP2011527304A; WO2010003806A3; ZA201008796B; CZ201110A3; AU2009268225A1; WO2010003806A2; BRPI0910199A2; KR20110028344A; EA201100184A1; CL2011000030A1; EP2299967A2; MX2011000301A

Abstract

The invention relates to a method and a product for lightening of skin and also for blemish removal on the skin. The invention provides for a method of lightening skin comprising the sequential steps, in any order, of; a) applying an alcohol having carbon chain length of 2 to 4, to the skin; and b) applying a skin lightening agent to said skin. The invention also provides for a kit for skin lightening comprising an alcohol having carbon chain length of 2 to 4 and a separately packaged skin lightening agent, along with instructions for their use. It is particularly preferred that the alcohol is impregnated in porous water-insoluble substrate.

Description

The method of bright skin

Technical field

The present invention relates to a kind of method of bright skin.

Background technology

Many people, particularly the people from the torrid zone for example has than living in the more dark skin away from the people in the torrid zone from the people in Asia and Africa.The people of dark skin wishes to have more shallow skin color like this.On the other hand, live in that for example Europe and people from North America (it innately has very shallow skin usually) like having more dark skin appearance away from the people of torrid areas.They attempt to reach such purpose by tanned under daylight.Tanned effort has like this produced uneven dark color spots or fault on their skin, this is disappointed.In order to solve top these two problems, carried out a large amount of research in the past few decades, and developed the method for bright skin.Many cosmetic compositions also are commercially available.

Most these compositionss have comprised two kinds of bases.A kind of composition is a skin lightening agent.Skin lightening agent is such chemical compound, and it it is believed that has controlled melanic dispersion or suppressed tryrosinase.Popular skin lightening agent comprises nicotiamide, and carboxylic acid is Azelaic Acid and kojic acid for example, plant extract, hydroquinone etc.Nicotiamide (it is a kind of vitamin b 3 compound) is a kind of widely used like this skin lightening agent, is used for the local compositions of using.Second kind of composition in the cosmetic composition is opacifier, and it keeps color uvioresistant (UV) radiation of skin, its known skin tanning that causes.These opacifiers are by absorption or by stopping that incident UV ray works.This sunscreen compounds can be organic or inorganic in nature; They can natural existence or can be synthetic preparations.Skin lightening agent and sunscreen compounds have been used in combination in cosmetic composition synergistic benefits are provided.

A kind of popular cosmetic composition is based on GB 2 230 186 (Unilever, 1990).This patent disclosure a kind of cosmetic composition, it comprises nicotiamide, the UV-B opacifier is for example one or both among the Parsol 1789 and silicone compounds of Parsol MCX and UV-A opacifier for example.Said composition has produced than carrying out the bright skin effect that improves of known those compositionss of described when invention.Publication since above-mentioned patent in bright skin field rises, and has carried out a large amount of research and the claimed improvements of several patents between the several years.But, still study and develop better and more effective bright skin method and product.

The inventor has carried out the research in several years at present to this problem, and find that surprisingly (step comprises alcohol is administered to skin a kind of two-stage process, preferably use by wiping, another step comprises uses skin lightening agent on skin) the bright skin effect that improves than known method is provided.No matter order how, all obtained good result.

WO 01/78678 (Procter ﹠amp; Gamble, 2001) a kind of preformed device is described, be used for beneficial agent (benefit agent) is administered to skin, on hair or the fingernail, this device comprises the solid gel sheet with first and second relative surfaces, wherein this gel film comprises acceptable hydrophilic solvent on the Dermatology of one or more gelating agents and at least 10%, be characterised in that this first surface is coated with discrete coating composition at least in part, said composition comprises the beneficial agent of at least a skin, hair or fingernail.In many active substances, this beneficial agent can be a nicotiamide.The wiping cloth of therefore wherein sneaking into skin lightening agent is known.

JP 5 317 122 (Piase Anise, 1993) has described a kind of by formed cosmetic/sanitary belts such as Cotton Gossypii, non-woven fabrics, wet cotton papers, and it is used for the perspire of wiping skin.This cosmetic/sanitary belt is filled with cosmetics and disinfectant, and it is made of following: porous hollow ball shape granule, alcohol, water, allantoin, hydroxy chloride (hydroxyl chloride), paraffin, tea extract, L-menthol, flavouring agent etc.Keep skin not chap thus, and have cooling feeling, it it is said it is long-term continuing.Therefore the wiping cloth that comprises alcohol also is known.

But prior art is not instructed a kind of two-stage process, and a step comprises uses alcohol, and another step comprises uses skin lightening agent, and this two-step method provides the bright skin benefit that improves.

Therefore a target of the present invention is a kind of method of exploitation, and it provides the bright skin effect that improves than known method.

Another target of the present invention provides a kind of bright skin product, its than the product that can get more effective aspect the bright skin.

Another target of the present invention provides a kind of method and bright skin product, and it removes the fault on the skin effectively.

Summary of the invention

According to a first aspect of the invention, provide a kind of method of bright skin, it comprises the following consecutive steps of any order:

A) on skin, use the alcohol of carbon chain lengths 2-4; With

B) on described skin, use skin lightening agent.

Particularly preferably be the step of using skin lightening agent and then use the step of alcohol.

According to a further aspect in the invention, provide a kind of test kit (kit) that is used for bright skin, it comprises the alcohol of carbon chain lengths 2-4 and the skin lightening agent of packing separately, and their directions for use.

The specific embodiment

Whole herein umbers is according to the weight meter, unless otherwise prescribed.

The invention provides a kind of two-step method of bright skin.This method has produced and has been better than at present known those bright skin effect.A step comprises uses alcohol on skin.Another step comprises on the identical zone of skin uses skin lightening agent.Therefore it is a kind of sequential grammar (sequential method).Any one step can at first be carried out, and carries out another step then.But preferred order is at first to use alcohol, is the step of using skin lightening agent then.This second step can be carried out behind first step immediately, that is, and and several seconds or in that a few minutes carry out thereafter behind first step.Preferred second step is to carry out in about 2 seconds-about 15 minutes behind first step.

The carbon chain lengths of described alcohol is 2-4.This alcohol is volatile in common ambient temperature (that is, 10-50 ℃) preferably.The suitable alcohol that is used for the inventive method is ethanol or isopropyl alcohol.This alcohol can be mixed with alcohol composition.The form that this alcohol composition is suitable is emulsifiable paste (cream), gel, mousse, spray (aerosol spray), club (stick), powder or granule.Preferably this alcohol is filled in the porous water-insoluble base material.The skin surface that is desirable to the amount that is administered to the alcohol on the skin and is every square centimeter of 5mg-50mg/ is long-pending.When this alcohol is when transmitting by alcohol composition, the preferred amount of this alcohol is the 10-95 weight % of described alcohol composition.

A kind of method that preferably alcohol is administered on the skin is carried out from the porous water insoluble sheet.Such sheet is also referred to as wiping cloth.Constitute the suitable material of wiping cloth and be woven or non-woven polymer sheet or by natural material make as cellulose Cotton Gossypii or paper and other natural materials silkworm silk for example for example, Pilus Caprae seu Ovis, perhaps above-mentioned lamilated body.The wiping cloth of being made by Cotton Gossypii is particularly preferred.This wiping cloth can suitably be filled (pack) and be guaranteed that alcohol remains in the wiping cloth in storage and transportation, when consumer uses till.

Preferably skin benefit agent is delivered to skin by alcohol/alcohol composition.Therefore should alcohol/alcohol composition can have dissolving or be dispersed in wherein skin benefit agent.Useful skin benefit agent is selected from opacifier, skin lightening agent, vitamin, pharmaceutically active substance, infiltration improving agent, skin texture improver, antioxidant, antiinflammatory, perhaps emollient.The preferred amount of this skin benefit agent is the 0.1-10 weight % of described alcohol.Do not wish to be confined to theory, it is believed that the skin benefit agent that transmits by alcohol is better by higher infiltration (higher penetration) or be sent to by any other mechanism on the target location of skin.Other beneficial agent (it may not be compatible in water base or emulsion-based compositions) can transmit by alcohol by the present invention.

This alcohol can also be administered on the skin by spray (aerosol spray).In this method, compress the mixture of the propellant of pure and mild pressurization, and be filled in the jar.This jar has metering valve, and it can be used to produce the spraying that is administered on the skin.This propellant gas can be for example butane or a propane of liquefied petroleum gas.

Another suitable manner that volatile alcohol is administered on the skin is to carry out via club (stick), for example is generally used for using deodorizer (deodorant).

Another step of the inventive method comprises skin lightening agent is administered on the skin.This skin lightening agent preferably is delivered to skin by cosmetic composition.Only skin lightening agent is a vitamin b 3 compound.Suitable vitamins B3 chemical compound is selected from nicotinic acid (niacin), nicotiamide (niacinamide), nicotinyl alcohol (nicotinyl alcoho1), perhaps its derivant or salt.Most preferred skin lightening agent is a nicotiamide.Skin lightening agent is preferably sneaked into following amount: the 0.05-10 weight % of cosmetic composition.Preferred amount is 0.1-10%, and most preferred amount is 0.2-5%, by the weight of compositions.

Other vitamin that serve as skin lightening agent can advantageously comprise the bright skin effect that provides other in this cosmetic composition.These comprise vitamin B6, vitamin C, vitamin A or their precursor.The mixture of vitamin also can be used for compositions of the present invention.A kind of particularly preferred additional vitamins is a vitamin B6.

The example of other indefinitenesses of useful in this article skin lightening agent comprises adapalene (adapalene), Aloe extract, DL-Lactic acid ammonium salt.; arbutin (arbutin), Azelaic Acid, fourth hydroxyanisol; the fourth hydroxy-methylbenzene, citrate (citrate esters), deoxyarbutin (deoxyarbutin); 1; 3 diphenyl propane derivatives, 2,5 resorcylic acids and its derivant; 2-(4-acetoxyl group phenyl)-1; 3 zineb (dithane), 2-(4-hydroxy phenyl)-1,3 zineb; ellagic acid (ellagic acid); glucopyanosyl-1-acid ascorbyl ester (gluco pyranosyl-1-ascorbate), gluconic acid, glycolic; green tea extract; 4-hydroxy-5-methyl base-3[2H]-furanone, hydroquinone, 4 hydroxyanisols and its derivant; the 4-hydroxybenzoic acid derivative; Hydroxycaprylic acid, inositol acid ascorbyl ester, kojic acid; lactic acid; citron extract, linoleic acid, ascorbyl magnesium phosphate; the 5-MEXORYL SAM; 2,4 resorcinol derivatives, 3; 5 resorcinol derivatives; salicylic acid, 3,4; 5 trihydroxy benzyl derivatives, and composition thereof.

Cosmetic composition randomly comprises opacifier.Ultraviolet light is the main cause that skin deepens.Therefore, for the purpose of bright skin, the compositions that comprises UVA and/or UVB opacifier makes us expecting.Organic or inorganic sunscreen/sunscreen (sun-blocks) is applicable in the said composition.

Useful in the present invention preferred opacifier is a p-methoxycinnamic acid 2-Octyl Nitrite (2-ethylhexyl-p-methoxycinnamate); PAROSOL 1789; 2-hydroxyl-4-methoxybenzene ketone, octyldimethyl-para-amino benzoic acid and composition thereof.Particularly preferred opacifier is selected from p-methoxycinnamic acid 2-Octyl Nitrite, the 4-tert-butyl group-4 '-methoxy dibenzoyl base-methane or its mixture.

Other conventional opacifiers that are applicable to cosmetic composition of the present invention comprise 2-hydroxyl-4-methoxybenzene ketone, octyldimethyl-para-amino benzoic acid, digalloyl trioleate (digalloyltrioleate), 2,2-dihydroxy-4-methoxybenzene ketone, 4-(two (hydroxypropyl)) benzocaine, 2-cyano group-3,3-diphenylacrylate 2-Octyl Nitrite, salicylic acid 2-Octyl Nitrite, para-amino benzoic acid glyceride, 3,3,5-trimethylcyclohexyl salicylate, methyl 2-aminobenzoate, to dimethyl-amino benzoic Acid or Aminobenzoate, to dimethyl-amino-benzoic acid 2-Octyl Nitrite, 2-Phenylbenzimidazole-5-sulfonic acid, 2-(to dimethylaminophenyl)-5-sulfonicbenzoxazoic acid (benzoxazole sulfonic acid) and the mixture of these chemical compounds.

The opacifier of safety and effective dose can be blended in the compositions for use of the present invention.It is about 10% that said composition preferably comprises about 0.1%-, more preferably the about opacifier of 0.1%-about 5%.

Useful inorganic sunscreen also can be preferred among the present invention.They comprise for example zinc oxide ferrum oxide, and silicon dioxide is fumed silica for example, and titanium dioxide.

Being particularly suitable for of the present invention is superfine titanic oxide, and it is in its two kinds of forms any one, that is, and and water-dispersible titanium dioxide and oily dispersibility titanium dioxide.Water-dispersible titanium dioxide is superfine titanic oxide, its particle be do not coat or its be to coat with such material, this material is that described particle has been given hydrophilic surface property.Such examples of material comprises aluminium oxide and aluminium silicate.

Oil dispersibility titanium dioxide is superfine titanic oxide, and its particle shows hydrophobic surface property, and it for this purpose, can be coated with for example aluminium stearate of metallic soap, and Aluminum trilaurate or zinc stearate perhaps coat with the organic silicone chemical compound.

" superfine titanic oxide " is meant the TiO 2 particles with following particle mean size: less than 100nm, and preferred 70nm or still less, more preferably 10-40nm and most preferably 15-25nm.

By the two mixture of water-dispersible superfine titanic oxide and oily dispersibility superfine titanic oxide is locally applied on the skin, can realize the two harmful effect of the anti-UV-A of protection skin that improves and UV-B ray.

Superfine titanic oxide is a kind of preferred inorganic sunscreen.The total amount that preferably is blended into the sunscreen in the compositions of the present invention is the 0.1-5 weight % of compositions.

Cosmetic composition has preferably comprised diluent, dispersant or the carrier that acceptable medium (vehicle) on the cosmetics is served as existing other materials in the compositions, promotes their distribution when compositions is administered on the skin.Cosmetic composition preferably is mixed with powder, thin slice (flake), washing liquid, emulsifiable paste (cream), the form of gel or mousse.Vanishing cream base (vanishing cream base) is particularly preferred.Vanishing cream base comprise fatty acid and fatty acid soaps the two.These concentration in vanishing cream base are 5-25 weight %C normally ₁₂-C ₂₀The fatty acid soaps of fatty acid and 0.1-10 weight %.

The medium of non-water (vehicle) can comprise liquid or solid emollient, solvent, wetting agent, thickening agent and powder.The example of each in the medium of these types (its can single use or use as the mixture of one or more media) is as follows:

Emollient, stearyl alcohol for example, single castor oil acid glyceride, ermine oil, spermol, isostearic acid isopropyl ester, stearic acid, Palmic acid isobutyl ester, Standamul 7061, oleyl alcohol, isopropyl laurate, lauric acid hexyl ester, decyl oleate, octadecane-2-alcohol, different spermol, EICOSANOL (eicosanyl alcohol), behenyl alcohol (behenyl alcohol), cetin, silicone oil is dimethyl polysiloxane for example, n-butyl sebacate, isopropyl myristate, isopropyl palmitate, isopropyl stearate, butyl stearate, Polyethylene Glycol, 2,2'-ethylenedioxybis(ethanol)., lanoline, cupu oil, Semen Maydis oil, Oleum Gossypii semen, olive oil, palm kernel oil, rapeseed oil, safflower oil, Radix Oenotherae erythrosepalae oil, soybean oil, Oleum Helianthi, American Avocado Tree oil, Oleum sesami, Oleum Cocois, Oleum Arachidis hypogaeae semen, Oleum Ricini, Acetylated lanolin alcohols., vaseline (petroleum jelly), mineral oil, tetradecanoic acid butyl ester, isostearic acid, Palmic acid, linoleic acid isopropyl ester, the lactic acid Lauryl Ester, lactic acid tetradecane ester, decyl oleate and tetradecanoic acid tetradecane ester;

Propellant, propane for example, butane, iso-butane, dimethyl ether, carbon dioxide and nitrous oxide (nitrous oxide);

Solvent, ethanol for example, isopropyl alcohol, acetone, ethylene glycol monoethyl ether, diethylene glycol monobutyl ether and diethylene glycol monoethyl ether; With

Powder, Chalk for example, Talcum, bleaching earth (fullers earth), Kaolin, starch, glue (gums), silica sol sodium polyacrylate, tetraalkyl and/or trialkyl aryl Montmorillonitum, the aluminium-magnesium silicate of chemical modification, organically-modified illiteracy unsticking soil, aluminium hydrosilicate, fumed silica, CVP Carbopol ETD2050, sodium carboxymethyl cellulose and ethylene glycol monostearate.

The common amount of acceptable medium is the 10-99.9 weight % of cosmetic composition on the cosmetics, preferred 50-99 weight %, and can under the situation that does not have other cosmetics adjuvant, be used to supply described compositions.

Optional cosmetic composition

Compositions of the present invention can comprise other optional ingredients of wide region.Example comprises: antioxidant, binding agent, bio-additive, buffer agent, coloring agent, thickening agent, polymer, astringent, flavouring agent, wetting agent, opacifiers (opacifying agent), regulator, remover, the pH regulator agent, antiseptic, natural extract, essential oil, skin perception agents, skin toning agent and skin rehabilitation agent.

According to a further aspect in the invention, provide a kind of test kit that is used for bright skin, it comprises pure and mild skin lightening agent (it is to pack separately) and their operation instruction of carbon chain lengths 2-4.This operation instruction has comprised that wherein two contents of packing separately must be according to the order of its use.This explanation has also comprised must use the time of the content of second packing after the content of first packing uses.

In test kit, preferably alcohol composition is filled in a plurality of porous water-insoluble sheets.Alternatively, alcohol composition is filled (pack) in aerosol can with propellant.

The present invention will further specify by following indefiniteness embodiment now.

Embodiment

Embodiment 1-3: in short term tests, the method for described system is than the efficient of known method.

16 tests of 5 days that the volunteer participates in have been carried out.This test is made up of following program:

Embodiment 1

The specific part of labelling volunteer forearm, and use every day 5 times commercially available cosmetic composition " the Fair ﹠amp that contains 1.25% bright skin active substance nicotiamide with the amount of 3mg/ square centimeter; Lovely ", about 1.5 hours are once.

Embodiment 2

The similar specific part of labelling volunteer forearm, and clean once with soap every morning, continue 10 days.Consisting of of this cleaning: with soap slab wiping 10 times, the soap that washes out mark part with a large amount of water is removed whole soaps subsequently at marked region.In case washed described soap, and with described zone dab do after, will use for five times with the used identical cosmetic composition of embodiment 1 every day, about 1.5 hours once.

Embodiment 3

With the similar specific part of volunteer's forearm in wiping every morning once with the plumety that soaks the solvent (ethanol) that 0.1ml is arranged.Use the used cosmetic composition of embodiment 1 every day for five times, about 1.5 hours once.

Bright skin score is by assessment experts, uses color scale, determines on the score value of 1-10.The data of table 1 have gathered average bright skin mark, and it is the variation of skin color with respect to initial skin color.Low more fraction representation high more bright skin degree.

Table 1

Embodiment	5 days ends
		1	-0.18
2	-0.18
		3	-0.27

The data of table 1 show with the method for prior art to be compared, and when using the inventive method (embodiment 3), observes the bright skin of obvious higher degree.

Embodiment 4-6: in the test that prolongs, the method for described system is than the efficient of known method.

36 volunteers have participated in the test in one 8 week.This test is made up of following program:

Embodiment 4

The specific part of labelling volunteer dorsal part forearm (dorsal forearm) (forearm is exposed to the part of the sun), and use every day 2 times commercially available cosmetic composition " the Fair ﹠amp that contains 1.25% bright skin active substance nicotiamide with the amount of 0.5g; Lovely ", morning, once another time was after about 4 hours interval.

Embodiment 5

The different part of labelling volunteer dorsal part forearm, and with containing wiping every morning of the alcoholic acid cotton wiping cloth of 2ml once.15 minute after embodiment 4 used cosmetic compositions be administered to this mark part on thereafter.After 4 hours interval on the same day, repeat the wiping of the wiping cloth that soaks with alcohol, use the complete like this program of cosmetic composition subsequently.

Embodiment 6

On the similar portions of volunteer's dorsal part forearm, be similar to the processing of embodiment 5, comprise 3% ascorbic acid except described alcohol.

Bright skin score is by assessment experts, uses color scale, determines on the score value of 1-10.The data of table 2 have gathered average bright skin mark, and it is a skin color with respect to the variation of initial skin color when 0 week.Low more fraction representation high more bright skin degree.

Table 2

Embodiment	2 weekends	4 weekends	8 weekends
				4	-0.142	-0.257	-0.386
5	-0.184	-0.337	-0.404
				6	-0.247	-0.410	-0.477

The data of table 2 show with the method for prior art to be compared, and when using the inventive method (embodiment 5 and 6), obtains the bright skin of obvious higher degree.

Embodiment 7 and 8: the influence of order of steps

5 volunteers have carried out a test of 5 days.This test is made up of following program:

Embodiment 7

The specific part of labelling volunteer forearm (1 square centimeter of zone), and use every day 5 times commercially available cosmetic composition " the Fair ﹠amp that contains 1.25% bright skin active substance nicotiamide with the amount of 3mg/ square centimeter; Lovely Multivitamin ", about 1.5 hours are once.

Embodiment 8

On the similar specific part of volunteer's forearm, use the used cosmetic composition of embodiment 7.After these 15 minutes, use the identical zone of plumety wiping of the soak with ethanol of 0.1ml.Repeat this program 5 times every day, about 1.5 hours once.

Bright skin score on specific part is by assessment experts, uses color scale, determines on the score value of 1-10.The data of table 3 have gathered average bright skin mark, and it is a skin color with respect to the variation of initial skin color 0 day the time.Low more fraction representation high more bright skin degree.

Table 3

Embodiment	5 days ends of research
		7	-0.375
8	-0.4375

The data of table 3 show, compare with the method for prior art, have obtained better bright skin equally when using following order of steps: at first use cosmetic composition, subsequently alcohol is administered on the skin.

Embodiment 9 and 10:In the test that prolongs, the effect of the inventive method in the bright skin of fault

16 volunteers have participated in the test in one 8 week.This test is made up of following procedure.

Determine the fault paid close attention on volunteer's cheek.Use the fault color scale, the color to this fault on the score value of 0.5-10 is carried out classification.

Embodiment 9

" Fair ﹠amp with about 0.25g; Lovely Skin Clarity ", there is the commercially available prod of 1.25% nicotiamide to be administered on the fault of being paid close attention to as skin lightening agent.Every day twice, carried out this using at interval in 90 minutes.

Embodiment 10

This program groups becomes the fault of being paid close attention to the cotton swab wiping of about 2ml soak with ethanol.After this several seconds (2-5 second), use the used cosmetic composition of embodiment 12.Every day twice, carried out this using at interval in 90 minutes.

Bright skin score on each specific fault is by assessment experts, uses color scale, determines on the score value of 0.5-10.The data of table 4 have gathered average bright skin mark, and it is a skin color with respect to the variation of initial skin color when 0 week.Low more fraction representation high more bright skin degree.

Table 4

Embodiment	2 weekends	6 weekends	8 weekends
				9	-0.27	-0.91	-1.03
10	-0.37	-0.95	-1.22

The data of table 4 show with known method to be compared, even when using on the time that prolongs, method of the present invention provides better fault bright skin.

Claims

1. the method for a bright skin, it comprises the following consecutive steps of any order:

A) on skin, use the alcohol of carbon chain lengths 2-4; With

B) on described skin, use skin lightening agent.

2. the method for claim 1, it comprises step (a), then step (b).

3. claim 1 or 2 method, wherein said alcohol is ethanol or isopropyl alcohol.

4. each method wherein is filled into described alcohol in the porous water-insoluble base material in the aforementioned claim.

5. each method in the aforementioned claim is wherein with skin benefit agent dissolving or be distributed in this alcohol.

6. each method in the aforementioned claim, wherein this skin lightening agent is a vitamin b 3 compound.

7. the method for claim 6, wherein this vitamin b 3 compound is selected from nicotinic acid, nicotiamide, its derivant of nicotinyl alcohol and its salt.

8. each method in the aforementioned claim, wherein this skin lightening agent sends skin to by cosmetic composition.

9. the method for claim 8, wherein the amount of this vitamin b 3 compound is the 0.2-5 weight % of this cosmetic composition.

10. each method in the aforementioned claim 8 or 9, wherein this cosmetic composition comprises the opacifier of 0.1-10 weight %.

11. each method among the aforementioned claim 8-10, wherein this cosmetic composition comprises: (i) C of 5-25 weight % ₁₂-C ₂₀Fatty acid and the (ii) fatty acid soaps of 0.1-10 weight %.

12. a test kit that is used for bright skin, it comprises the skin lightening agent of the pure and mild independent packing of carbon chain lengths 2-4, and their operation instruction.

13. the test kit of claim 12 wherein is filled into this alcohol in the porous water-insoluble base material.