JPH11171756A - Skin whitening cosmetic - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain the subject cosmetic having the effect of rapidly whitening the dark skin. SOLUTION: This skin whitening cosmetic is obtained by formulating a combination of a hesperidin compound with diisopropylamine dichloroacetate; wherein the amounts of the hesperidin compound and the diisopropylamine dichloroacetate to be formulated are appropriately 0.01-10 wt.% (esp. pref. 0.05-5 wt.%) based on the total amount of this cosmetic, respectively.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a whitening cosmetic having an effect of rapidly lightening dark skin.

[0002]

2. Description of the Related Art Conventionally, whitening cosmetics for the purpose of preventing and treating skin spots and freckles include ascorbic acid and its derivatives, hydroquinone derivatives, kojonic acid and other pyrones. And placenta extract such as placenta extract.

[0003] These substances have effects such as suppression of melanin production and pale bleaching action of the produced melanin, and are widely known as substances having a whitening effect. However, as for these substances, for example, ascorbic acid and its derivatives often have insufficient storage stability or an insufficient effect of preventing inflammation due to ultraviolet rays. Hydroquinone derivatives also have problems such as insufficient safety. As described above, it is difficult to obtain a whitening cosmetic which is totally excellent in melanin production inhibitory effect, melanin pale bleaching effect, anti-inflammatory effect, safety and the like.

[0004] That is, an object of the present invention is to provide a whitening cosmetic which is excellent in the effect of inhibiting the production of melanin and the bleaching action of melanin in light color.

[0005]

Means for Solving the Problems The present inventors have conducted intensive studies to achieve the above object, and as a result, when a hesperidin compound and diisopropylamine dichloroacetate are combined, the effect of suppressing the production of melanin, The present inventors have found that a whitening cosmetic having excellent light-color bleaching action can be obtained and completed the present invention.

[0006]

DESCRIPTION OF THE PREFERRED EMBODIMENTS The details of the structure of the present invention will be described below.

The hesperidin compound used in the present invention includes hesperidin contained in citrus peel and the like.
Neohesperidin and the like, for example, can be obtained by extraction with an organic solvent system such as ethanol water, ethanol, diethyl ether, acetone, hexane and the like, and further, methyl hesperidin obtained by methylation synthesis of hesperidin with dimethyl sulfate Can also be mentioned.

The compounding amount of the hesperidin compound used in the present invention is based on the total amount of the whitening cosmetic.
0.01 to 10% by weight is suitable, and particularly preferably 0.05 to 5% by weight. When the amount is less than 0.01% by weight, the manifestation of the effect is not sufficient, and when the amount is more than 10% by weight, no further effect can be expected.

Further, diisopropylamine dichloroacetate (abbreviated as DADA) used in the present invention is represented by the following formula, is in the form of a white crystalline powder, has almost no smell, has little bitter taste, Easy to dissolve in ethanol, etc. The melting point is 118-122 ° C, and the pH of a 5% aqueous solution is 5.6-6.8.

[0010]

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The compounding amount of diisopropylamine dichloroacetate used in the present invention is suitably 0.01 to 10% by weight, particularly preferably 0.05 to 5% by weight, based on the total amount of the whitening cosmetic. When the amount is less than 0.01% by weight, the manifestation of the effect is not sufficient, and when the amount is more than 10% by weight, no further effect can be expected.

The whitening cosmetic of the present invention contains, in addition to the above-mentioned additives, dyes, fragrances, preservatives, surfactants, pigments, antioxidants, humectants, ultraviolet absorbers and the like. It can be appropriately blended within the range achieved.

[0013] As the dosage form of the whitening cosmetic of the present invention, conventional ones are applied, and examples thereof include creams, emulsions, lotions, packs, essences, and powdered cosmetics. For example, in the case of an emulsion, it can be produced by an ordinary method of emulsifying and dispersing an oil phase and an aqueous phase, each of which is heated and dissolved, and cooling.

[0014]

The present invention will be described below in detail based on examples and comparative examples. The percentages shown in the examples are percentages by weight. The skin color brightness recovery test method and the sensory evaluation test described in the examples are as follows.

(1) Skin Lightness Recovery Test Method The back skin of 20 subjects was irradiated with ultraviolet rays in the UV-B region twice as much as the minimum erythema dose, and a sample-applied portion and a non-applied portion were set. The reference lightness (V0 value, V0 'value) was measured. Subsequently, the sample was applied to the application site twice a day for 15 times.
After continuous application for three weeks, the lightness (Vn value, Vn ') of the skin at the application site and the non-application site after 3, 6, 9, 12, and 15 weeks
Was measured, and the recovery of skin color was evaluated according to the following criteria. The lightness of the skin (Munsell color system V value)
Was calculated from the X, Y, and Z values obtained by measuring with a high-speed spectral colorimeter. In addition, the evaluation was shown as an average value of the evaluation points of the 20 subjects after 3 weeks and 6 weeks.

[0016]

(2) Sensory Evaluation Test Twenty-five subjects suffering from pigmentation evaluated the whitening effect by using the sample continuously for three weeks. The results are shown by the number of subjects who answered that there was a whitening effect.

Examples 1 and 2, Comparative Examples 1 to 3 (Preparation of Hesperidin and Methyl Hesperidin) Hesperidin is obtained by shading the pericarp of mandarin orange and drying it into powder using a crusher. 400 ml of ethanol was added to the powder (50 g), heated to 75 ° C. and refluxed for 5 hours. An ethanol extract was obtained by the digestion. The solvent was removed from the ethanol extract using an evaporator to obtain an oil containing hesperidin. Further, dimethyl sulfate is reacted with the hesperidin-containing ethanol extract by a conventional method,
Methylated hesperidin was obtained. Hesperidin, methyl hesperidin, and diisopropylamine dichloroacetate were blended in the composition shown in Table 1, and a skin cream was prepared based on the following preparation method.

Preparation method (A) is uniformly dissolved at 70 ° C. and B is uniformly dissolved at 50 ° C.
After stirring (B) into (A) while stirring to emulsify and disperse, the mixture is cooled to 30 ° C. while stirring to prepare.

[0020]

[Table 1]

[0021]

[Table 2]

The above test was carried out using these skin creams as samples, and the results obtained are shown in Table 3.

[0023]

[Table 3]

As can be seen from these results, the skin creams of Examples 1 and 2 of the present invention exhibited a sufficient whitening effect. In addition, the skin creams of Examples 1 and 2 were found to have a smooth and smooth skin. On the other hand, the skin creams of Comparative Examples 1 to 3 did not show a sufficient effect, and were inferior to the examples of the present invention.

[0025]

As described above, it is apparent that the present invention provides a whitening cosmetic having an effect of rapidly lightening dark skin.

Claims (1)

[Claims] 1. A whitening cosmetic comprising a combination of a hesperidin compound and diisopropylamine dichloroacetate.