JPH08291039A - Skin-lightening cosmetic - Google Patents

Abstract

PURPOSE: To obtain a skin-lightening cosmetic which can rapidly bleaching the dark skin by using carnitine and/or carnitine chloride and an ascorbic acid derivative. CONSTITUTION: This cosmetic contains 0.01-30wt.% of carnitine and/or carnitine chloride and 0.01-3wt.% of an ascorbic acid derivative. In addition, colorants, perfumes, a preservative, surfactants, pigments, an antioxidant, a moisturizer, an ultraviolet absorbent are properly formulated to prepare a cosmetic in the form of cream, emulsion, cosmetic lotion, pack, essence or powder. Carnitine and carnitine chloride promote the skin functions to improve the skin fatigue or loosening and prevent skin aging and wrinkles, give the skin a moistened feeling and gloss and accelerate the metabolism of the hair roots. The combination with an ascorbic acid derivative develops a synergistic effect on the actions cited above, and further, exhibits an inhibitory effect on melanin formation and a lightening effect on skin color.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a whitening cosmetic having an effect of rapidly lightening dark skin.

[0002]

BACKGROUND OF THE INVENTION Conventionally, whitening cosmetics for the purpose of preventing or treating spots and freckles on the skin include ascorbic acid and its derivatives, hydroquinone derivatives, pyrones such as kojic acid. , Placenta extract such as placenta extract are mixed.

These substances are widely known as substances having a whitening effect because they have the effects of suppressing the production of melanin, light-color bleaching action of the produced melanin and the like. However, these substances, for example, ascorbic acid and its derivatives, often have insufficient storage stability or do not have sufficient anti-inflammatory effect due to ultraviolet rays. Further, the hydroquinone derivative has problems such as insufficient safety. As described above, it is difficult to obtain a whitening cosmetic composition that is comprehensively excellent in the effect of suppressing the production of melanin, the light-color bleaching action of melanin, the effect of preventing inflammation, and the safety.

That is, an object of the present invention is to provide a whitening cosmetic composition which is excellent in the effect of suppressing the production of melanin and the light-color bleaching action of melanin.

[0005]

Means for Solving the Problems As a result of intensive studies to achieve the above object, the present inventors have found that when carnitine and / or carnitine chloride and an ascorbic acid derivative are combined in a cosmetic composition, The present invention has been completed by finding that a whitening cosmetic excellent in the effect of suppressing the production of melanin and the light-color bleaching action of melanin can be obtained.

Carnitine (Carn) used in the present invention
Itine) means γ-amino-β-hydroxybutyrobetaine (3-Carboxy-2-Hydroxy-
N, N-N, trimethyl-1-propami
Numerous hydroxide, C ₇ H ₁₅ NO ₃ ),
Widely present as a basic component of skeletal muscle, usually extracted from meat of pigs, calves, and horses, involved in fatty acid transport to mitochondria in the form of acylcarnitine, and promoting fatty acid oxidation there. It is known to act to promote fatty acid synthesis. In addition, carnitine chloride is a salt of carnitine, γ-amino-β-hydroxybutyrobetaine hydrochloride (C ₇ H ₁₆ ClNO ₃ ), which increases the concentration of digestive enzymes and acids in human digestive juices and increases the concentration of gastric juice. In order to promote secretion, it is used by oral administration and injection for gastric juice secretion disorder, hypogastric juice, anorexia, etc. Carnitine and carnitine chloride are water-soluble substances, which are optical isomers in terms of chemical structure, D-type, L-type, and DL which is a mixture thereof.
There are molds, any of which can be used in the present invention.

The inventors of the present invention have disclosed in Japanese Patent Laid-Open No. 51-148042.
Carnitine and carnitine chloride enhance skin function, cure skin fatigue and sagging, prevent skin aging and fine wrinkles, and make skin moist and shiny, while promoting hair root metabolism. We found that it promoted the development of head hair roots. However, the above carnitine and carnitine chloride alone showed almost no effect of suppressing the production of melanin, but this time, when the present inventors combined carnitine and carnitine chloride in combination with an ascorbic acid derivative, they were remarkably synergistic. It has been newly confirmed that it exerts its effect, improves the effect of suppressing the production of melanin, and exerts the effect of lightening the skin.

The structure of the present invention will be described in detail below. The ascorbic acid derivative used in the present invention is a known whitening agent, and ascorbic acid, ascorbic acid phosphoric acid ester, ascorbic acid sulfuric acid ester, ascorbic acid higher fatty acid ester, and salts thereof, and the like, and as salts thereof, Sodium salt, potassium salt, magnesium salt, calcium salt, barium salt, ammonium salt, monoethanolamine salt, diethanolamine salt, triethanolamine salt, monoisopropanolamine salt, diisopropanolamine salt, triisopropanolamine salt and the like. However, the present invention is not limited to these.

Examples of the ascorbic acid phosphoric acid ester include ascorbic acid-2-phosphoric acid ester and ascorbic acid-3-phosphoric acid ester, and examples of the ascorbic acid sulfuric acid ester include ascorbic acid-2-phosphoric acid ester.
Sulfuric acid ester and ascorbic acid-3-sulfuric acid ester, which are known substances and are disclosed in Japanese Examined Patent Publication No.
No. 7 and Japanese Patent Publication No. 54-21415. Furthermore, examples of higher ascorbic acid fatty acid ester include ascorbic acid-2-palmitic acid monoester and ascorbic acid-2,6-palmitic acid diester.

The content of carnitine and / or carnitine chloride is 0.
01 to 3.0% by weight is preferable. The content of the ascorbic acid derivative in the whitening cosmetic composition is preferably 0.01 to 30% by weight, more preferably 0.1 to 10% by weight, based on the total amount of the prescription components of the cosmetic composition. .

In addition to the above-mentioned additives, the whitening cosmetic composition of the present invention contains, in addition to the above-mentioned additives, pigments, fragrances, preservatives, surfactants, pigments, antioxidants, humectants, ultraviolet absorbers and the like. It can be appropriately blended within the range to be achieved.

As the dosage form of the whitening cosmetic composition of the present invention, usual ones are applied, and examples thereof include creams, emulsions, lotions, packs, essences, powder cosmetics and the like. For example, in the case of an emulsion, it can be produced by an ordinary method in which an oil phase and an aqueous phase are heated and dissolved, and then emulsified and dispersed and cooled.

[0013]

EXAMPLES The present invention will be described in detail below based on examples and comparative examples. In addition,% shown in the examples is% by weight. The skin color lightness recovery test method and sensory evaluation test described in Examples are as follows.

(1) Skin color lightness recovery test method The back skin of 20 subjects was irradiated with ultraviolet rays in the UV-B region at twice the minimum erythema dose, and a sample application site and a non-application site were set to determine the skin of each skin. The standard brightness (V0 value, V0 'value) was measured. Subsequently, the sample is applied to the application site twice a day 15 times.
Lightness (Vn value, Vn 'of the skin at the application site and non-application site after 3,6,9,12,15 weeks after continuous application for a week
Value) was measured and the recovery of skin color was evaluated according to the following criteria. The brightness of the skin (V value of Munsell color system)
Was calculated from X, Y, and Z values obtained by measurement with a high-speed spectrocolorimeter. The evaluation was shown by the average value of the evaluation points of 20 subjects after 3 weeks and 6 weeks.

[0015]

(2) Sensory evaluation test 25 subjects who suffered from pigmentation evaluated the whitening effect by continuously using the sample for 3 weeks. The results are shown by the number of subjects who answered that there was a whitening effect.

Examples 1 to 3 and Comparative Examples 1 to 4 Carnitine, carnitine chloride, ascorbic acid-2-phosphate ester salt, and ascorbic acid-2-sulfate ester salt were blended in the composition shown in Table 1, and the following preparation method was used. A skin cream was prepared based on

Preparation method (A) is uniformly dissolved at 70 ° C. and B at 50 ° C. to prepare (A)
(B) is poured into (A) with stirring to emulsify and disperse, and then cooled to 30 ° C. with stirring to prepare.

[0019]

[Table 1]

[0020]

[Table 2]

The above test was carried out using these skin creams as samples, and the results obtained are shown in Table 3.

[0022]

[Table 3]

As can be seen from these results, the skin creams of Examples 1 to 3 of the present invention were found to have a sufficient whitening effect. On the other hand, the skin creams of Comparative Examples 1 to 4 did not show a sufficient effect and were inferior to the examples of the present invention.

[0024]

As described above, it is apparent that the present invention provides a whitening cosmetic having an effect of rapidly lightening dark skin.

Claims (1)

[Claims] 1. A whitening cosmetic composition comprising carnitine and / or carnitine chloride in combination with an ascorbic acid derivative.