JP3229517B2 - Whitening cosmetics - Google Patents
Whitening cosmeticsInfo
- Publication number
- JP3229517B2 JP3229517B2 JP11776095A JP11776095A JP3229517B2 JP 3229517 B2 JP3229517 B2 JP 3229517B2 JP 11776095 A JP11776095 A JP 11776095A JP 11776095 A JP11776095 A JP 11776095A JP 3229517 B2 JP3229517 B2 JP 3229517B2
- Authority
- JP
- Japan
- Prior art keywords
- ascorbic acid
- skin
- carnitine
- effect
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Description
【０００１】[0001]
【産業上の利用分野】本発明は色黒の皮膚を速やかに淡
色化する効果を有する美白化粧料に関する。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a whitening cosmetic having an effect of rapidly lightening dark skin.
【０００２】[0002]
【従来技術及び発明が解決しようとする課題】従来よ
り、肌のしみやそばかす等の予防や治療を目的とする美
白化粧料には、アスコルビン酸およびその誘導体、ハイ
ドロキノン誘導体、コウジ酸等のピロン類、プラセンタ
ーエキス等の胎盤抽出物が配合されている。2. Description of the Related Art Conventionally, whitening cosmetics for the purpose of preventing and treating skin spots and freckles include pyrones such as ascorbic acid and its derivatives, hydroquinone derivatives and kojic acid. And placenta extract such as placenta extract.
【０００３】これらの物質は、メラニン生成の抑制、生
成したメラニンの淡色漂白作用等の効果を有し、美白効
果を有する物質として広く知られている。しかし、これ
らの物質は、例えばアスコルビン酸およびその誘導体
は、保存安定性が不十分であったり、紫外線による炎症
防止効果が十分に認められないことが多い。また、ハイ
ドロキノン誘導体は安全性が十分ではないなど問題があ
る。このようにメラニンの生成抑制効果、メラニンの淡
色漂白作用、炎症防止効果、安全性等において総合的に
優れる美白化粧料を得ることは困難である。[0003] These substances have effects such as suppression of melanin production and pale bleaching action of the produced melanin, and are widely known as substances having a whitening effect. However, as for these substances, for example, ascorbic acid and its derivatives often have insufficient storage stability or an insufficient effect of preventing inflammation due to ultraviolet rays. Hydroquinone derivatives also have problems such as insufficient safety. As described above, it is difficult to obtain a whitening cosmetic which is totally excellent in melanin production inhibitory effect, melanin pale bleaching effect, anti-inflammatory effect, safety and the like.
【０００４】即ち、本発明の目的は、メラニンの生成抑
制効果、メラニンの淡色漂白作用、に優れている美白化
粧料を提供することにある。[0004] That is, an object of the present invention is to provide a whitening cosmetic which is excellent in the effect of inhibiting the production of melanin and the bleaching action of melanin in light color.
【０００５】[0005]
【課題を解決するための手段】本発明者らは、上記目的
を達成するために鋭意検討した結果、化粧料中にカルニ
チン及び／又は塩化カルニチンと、アスコルビン酸誘導
体とを組み合わせて配合した場合、メラニンの生成抑制
効果、メラニンの淡色漂白作用、に優れている美白化粧
料が得られることを見出し本発明を完成した。Means for Solving the Problems The present inventors have conducted intensive studies to achieve the above object, and as a result, when carnitine and / or carnitine chloride and an ascorbic acid derivative are combined in a cosmetic, The present inventors have found that a whitening cosmetic excellent in melanin production inhibitory effect and melanin pale bleaching action can be obtained, and completed the present invention.
【０００６】本発明に用いられるカルニチン（Ｃａｒｎ
ｉｔｉｎｅ）とは、γ−アミノ−β−ヒドロキシブチロ
ベタイン（３−Ｃａｒｂｏｘｙ−２−Ｈｙｄｒｏｘｙ−
Ｎ，Ｎ−Ｎ，ｔｒｉｍｅｔｈｙｌ−１−ｐｒｏｐａｍｉ
ｎｉｕｍ ｈｙｄｒｏｘｉｄｅ、Ｃ7 Ｈ15ＮＯ3 ）で、
骨格筋の塩基性成分として広く存在し、通常はブタ、子
牛、ウマの肉から抽出され、アシルカルニチンの形でミ
トコンドリアへの脂肪酸輸送に関与し、そこでの脂肪酸
酸化を促進する働きのほか、脂肪酸合成促進の作用をす
ることが知られている。又、塩化カルニチンとはカルニ
チンの塩であるγ−アミノ−β−ヒドロキシブチロベタ
インハイドロクロライド（Ｃ7 Ｈ16ＣｌＮＯ3 ）で、人
体消化液中の消化酵素や酸の濃度を増加せしめると共に
胃液の分泌を促進するため、内服や注射液にて胃液分泌
障害、胃液減少症、食欲不振等に用いられている。カル
ニチン、塩化カルニチンは水溶性物質で、化学構造的に
光学異性体であり、Ｄ型、Ｌ型、その混合体であるＤＬ
型があり、そののいずれも本発明に使用できる。The carnitine (Carn) used in the present invention
itine) is γ-amino-β-hydroxybutyrobetaine (3-Carboxy-2-Hydroxy-
N, N-N, trimethyl-1-propami
sodium hydroxide, C 7 H 15 NO 3 )
It is widely found as a basic component of skeletal muscle and is usually extracted from pig, calf and horse meat, and is involved in fatty acid transport to mitochondria in the form of acylcarnitine, which promotes fatty acid oxidation there. It is known to act to promote fatty acid synthesis. Carnitine chloride is γ-amino-β-hydroxybutyrobetaine hydrochloride (C 7 H 16 ClNO 3 ), a salt of carnitine, which increases the concentration of digestive enzymes and acids in the digestive juices of the human body and increases the concentration of gastric juice. In order to promote secretion, oral and injection solutions are used for gastric secretion disorders, gastric hypotension, anorexia, etc. Carnitine and carnitine chloride are water-soluble substances, optically isomers in chemical structure, D-form, L-form, and a mixture thereof, DL
There are molds, any of which can be used in the present invention.
【０００７】本発明者らは、特開昭５１−１４８０４２
号で、カルニチン、塩化カルニチンが皮膚機能を亢進し
皮膚の疲労やたるみを治癒せしめ、皮膚の老化や小皺を
防止し、しっとりと色艶のある皮膚にする美肌作用と共
に、毛根の代謝を促進して頭部毛根の発育を促進するこ
とを見出して提案した。しかし、上記カルニチン、塩化
カルニチン単独では、メラニンの生成抑制する効果は殆
ど認められなかったが、今回、本発明者らは、カルニチ
ン、塩化カルニチンをアスコルビン酸誘導体と組み合わ
せて配合した場合、顕著に相乗効果を発揮して、メラニ
ンの生成抑制効果を向上させ、皮膚を淡色化する効果を
発現することを新たに認められた。The present inventors have disclosed in Japanese Patent Laid-Open Publication No.
In the issue, carnitine and carnitine chloride enhance skin function, heal skin fatigue and sagging, prevent skin aging and wrinkles, and promote hair root metabolism, as well as a beautiful skin effect to make the skin moist and colored and shiny. And promoted the growth of hair roots. However, carnitine and carnitine chloride alone had almost no melanin-suppressing effect.However, the present inventors have found that when carnitine and carnitine chloride are combined in combination with an ascorbic acid derivative, the synergism is markedly synergistic. It has been newly recognized that it exerts an effect, improves the effect of suppressing the production of melanin, and expresses the effect of lightening the skin.
【０００８】以下、本発明の構成について詳述する。本
発明で用いられるアスコルビン酸誘導体は、公知の美白
剤であり、アスコルビン酸、アスコルビン酸リン酸エス
テル、アスコルビン酸硫酸エステル、アスコルビン酸高
級脂肪酸エステル等及びそれらの塩等であり、それらの
塩としてはナトリウム塩、カリウム塩、マグネシウム
塩、カルシウム塩、バリウム塩、アンモニウム塩、モノ
エタノールアミン塩、ジエタノールアミン塩、トリエタ
ノールアミン塩、モノイソプロパノールアミン塩、ジイ
ソプロパノールアミン塩、トリイソプロパノールアミン
塩等が挙げられるが、これらに限定されるものではな
い。Hereinafter, the configuration of the present invention will be described in detail. The ascorbic acid derivative used in the present invention is a known whitening agent, such as ascorbic acid, ascorbic acid phosphate, ascorbic acid sulfate, ascorbic acid higher fatty acid ester and the like, and salts thereof. Sodium salt, potassium salt, magnesium salt, calcium salt, barium salt, ammonium salt, monoethanolamine salt, diethanolamine salt, triethanolamine salt, monoisopropanolamine salt, diisopropanolamine salt, triisopropanolamine salt and the like. However, the present invention is not limited to these.
【０００９】前記アスコルビン酸リン酸エステルとして
は、例えばアスコルビン酸−２−リン酸エステル、アス
コルビン酸−３−リン酸エステルが、またアスコルビン
酸硫酸エステルとしては、例えばアスコルビン酸−２−
硫酸エステル、アスコルビン酸−３−硫酸エステルであ
り、これらは公知の物質であって特公昭４４−３１２３
７号公報、特公昭５４−２１４１５号公報に記載されて
いる。更にまたアスコルビン酸高級脂肪酸エステルとし
ては、例えばアスコルビン酸−２−パルミチン酸モノエ
ステル、アスコルビン酸−２，６−パルミチン酸ジエス
テル等が挙げられる。Examples of the ascorbic acid phosphate include ascorbic acid-2-phosphate and ascorbic acid-3-phosphate, and examples of the ascorbic acid sulfate include ascorbic acid-2-phosphate.
Sulfates and ascorbic acid-3-sulfate, which are known substances and are disclosed in JP-B-44-3123.
7 and JP-B-54-21415. Furthermore, ascorbic acid higher fatty acid esters include, for example, ascorbic acid-2-palmitic acid monoester, ascorbic acid-2,6-palmitic acid diester and the like.
【００１０】カルニチン及び／又は塩化カルニチンの配
合量は、美白化粧料の処方成分全量を基準として、０．
０１〜３．０重量％が好ましい。又、アスコルビン酸誘
導体の美白化粧料中の含有量は、化粧料の処方成分全量
を基準として、０．０１〜３０重量％が好ましく、更に
好ましくは０．１〜１０重量％の範囲内である。The amount of carnitine and / or carnitine chloride is 0.1% based on the total amount of the components of the whitening cosmetic.
It is preferably from 0.1 to 3.0% by weight. The content of the ascorbic acid derivative in the whitening cosmetic is preferably 0.01 to 30% by weight, more preferably 0.1 to 10% by weight, based on the total amount of the prescription components of the cosmetic. .
【００１１】本発明の美白化粧料には、上記添加剤の他
に、色素、香料、防腐剤、界面活性剤、顔料、抗酸化
剤、保湿剤、紫外線吸収剤などを、本発明の目的を達成
する範囲内で適宜配合することができる。The whitening cosmetic of the present invention contains, in addition to the above-mentioned additives, dyes, fragrances, preservatives, surfactants, pigments, antioxidants, humectants, ultraviolet absorbers and the like. It can be appropriately blended within the range achieved.
【００１２】本発明の美白化粧料の剤型としては通常の
ものが適用され、たとえばクリーム、乳液、化粧水、パ
ック、エッセンス、粉体化粧料等が挙げられる。例えば
乳液の場合、油相及び水相をそれぞれ加熱溶解したもの
を乳化分散して冷却する通常の方法により製造すること
ができる。As the dosage form of the whitening cosmetic of the present invention, a usual one is applied, and examples thereof include creams, emulsions, lotions, packs, essences, and powdered cosmetics. For example, in the case of an emulsion, it can be produced by an ordinary method of emulsifying and dispersing an oil phase and an aqueous phase, each of which is heated and dissolved, and cooling.
【００１３】[0013]
【実施例】以下、実施例及び比較例に基づいて本発明を
詳述する。尚、実施例に示す％とは重量％である。実施
例に記載の皮膚色明度回復試験法、官能評価試験は下記
のとおりである。The present invention will be described below in detail based on examples and comparative examples. The percentages shown in the examples are percentages by weight. The skin color brightness recovery test method and the sensory evaluation test described in the examples are as follows.
【００１４】（１）皮膚色明度回復試験法 被験者２０名の背部皮膚にＵＶ−Ｂ領域の紫外線を最小
紅斑量の２倍照射し、試料塗布部位と非塗布部位を設定
して各々の皮膚の基準明度（Ｖ0 値，Ｖ0 ´値）を測定
した。引き続いて塗布部位には試料を１日２回ずつ１５
週間連続塗布した後、３，６，９，１２，１５週間後の
塗布部位及び非塗布部位の皮膚の明度（Ｖn 値，Ｖn ´
値）を測定し、下記の判定基準にしたがって皮膚色の回
復を評価した。尚、皮膚の明度（マンセル表色系Ｖ値）
は高速分光色彩計で測定して得られたＸ，Ｙ，Ｚ値より
算出した。また評価は被験者２０名ついて、３週間後及
び６週間後の評価点の平均値で示した。(1) Skin lightness recovery test method UV light in the UV-B region was irradiated to the back skin of 20 subjects twice as much as the minimum erythema dose, and a sample application site and a non-application site were set, and the skin of each skin was set. The reference lightness (V0 value, V0 'value) was measured. Subsequently, the sample was applied to the application site twice a day for 15 times.
After continuous application for three weeks, the lightness (Vn value, Vn ') of the skin at the application site and the non-application site after 3, 6, 9, 12, and 15 weeks
Was measured, and the recovery of skin color was evaluated according to the following criteria. The lightness of the skin (Munsell color system V value)
Was calculated from the X, Y, and Z values obtained by measuring with a high-speed spectral colorimeter. In addition, the evaluation was shown as an average value of the evaluation points of the 20 subjects after 3 weeks and 6 weeks.
【００１５】 [0015]
【００１６】（２）官能評価試験 色素沈着に悩む被験者２５名が試料を３週間連用し美白
効果を評価した。結果は「美白効果があった」と回答し
た被験者の人数で示した。(2) Sensory Evaluation Test Twenty-five subjects suffering from pigmentation evaluated the whitening effect by using the sample continuously for three weeks. The results are shown by the number of subjects who answered that there was a whitening effect.
【００１７】実施例１〜３，比較例１〜４ カルニチン、塩化カルニチン、アスコルビン酸−２−リ
ン酸エステル塩、アスコルビン酸−２−硫酸エステル塩
を表１の組成において配合し、下記の調製方法に基づい
てスキンクリームを調製した。Examples 1-3, Comparative Examples 1-4 Carnitine, carnitine chloride, ascorbic acid-2-phosphate ester salt, and ascorbic acid-2-sulfate ester salt were blended in the composition shown in Table 1, and the following preparation method was used. To prepare a skin cream.
【００１８】調製方法 （Ａ）を７０℃、Ｂを５０℃にて均一に溶解し、（Ａ）
を攪拌しながら（Ｂ）を（Ａ）に注入して乳化分散した
後、攪拌しながら温度３０℃まで冷却して調製する。Preparation method (A) is uniformly dissolved at 70 ° C. and B at 50 ° C.
After stirring (B) into (A) while stirring to emulsify and disperse, the mixture is cooled to 30 ° C. while stirring to prepare.
【００１９】[0019]
【表１】 [Table 1]
【００２０】[0020]
【表２】 [Table 2]
【００２１】これらのスキンクリームを試料として前記
の試験を実施し、得られた結果を表３に示す。The above tests were carried out using these skin creams as samples, and the results obtained are shown in Table 3.
【００２２】[0022]
【表３】 [Table 3]
【００２３】これらの結果から分かるように、本発明の
実施例１〜３のスキンクリームは十分な美白効果が認め
られた。一方、比較例１〜４のスキンクリームは、十分
な効果が認められず、本発明の実施例に比べて劣ってい
た。As can be seen from these results, the skin creams of Examples 1 to 3 of the present invention exhibited a sufficient whitening effect. On the other hand, the skin creams of Comparative Examples 1 to 4 did not show a sufficient effect, and were inferior to the Examples of the present invention.
【００２４】[0024]
【発明の効果】以上記載のごとく、本発明が色黒の皮膚
を速やかに淡色化する効果を有する美白化粧料を提供す
ることは明らかである。As described above, it is apparent that the present invention provides a whitening cosmetic having an effect of rapidly lightening dark skin.
───────────────────────────────────────────────────── フロントページの続き (58)調査した分野(Int.Cl.7，ＤＢ名) A61K 7/00 - 7/50 ＣＡ（ＳＴＮ)──────────────────────────────────────────────────続 き Continued on the front page (58) Field surveyed (Int. Cl. 7 , DB name) A61K 7/ 00-7/50 CA (STN)
Claims (1)
と、アスコルビン酸誘導体とを組み合わせて配合するこ
とを特徴とする美白化粧料。1. A whitening cosmetic comprising a combination of carnitine and / or carnitine chloride and an ascorbic acid derivative.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11776095A JP3229517B2 (en) | 1995-04-18 | 1995-04-18 | Whitening cosmetics |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11776095A JP3229517B2 (en) | 1995-04-18 | 1995-04-18 | Whitening cosmetics |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH08291039A JPH08291039A (en) | 1996-11-05 |
| JP3229517B2 true JP3229517B2 (en) | 2001-11-19 |
Family
ID=14719652
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP11776095A Expired - Fee Related JP3229517B2 (en) | 1995-04-18 | 1995-04-18 | Whitening cosmetics |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP3229517B2 (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6265364B1 (en) * | 1999-12-28 | 2001-07-24 | Colgate-Palmolive Company | Solid cleansing composition comprising a choline salt |
| DE10129504A1 (en) * | 2001-06-19 | 2003-01-09 | Beiersdorf Ag | Use of carnitine and / or one or more acyl-carnitines for the production of cosmetic or dermatological preparations for the treatment and / or prophylaxis of pigmentation disorders |
| KR20030066912A (en) * | 2002-02-06 | 2003-08-14 | 한불화장품주식회사 | A cosmetic composition |
| CN1964695A (en) * | 2003-03-28 | 2007-05-16 | 隆萨股份有限公司 | Topical l-carnitine compositions |
| JP3984188B2 (en) * | 2003-05-15 | 2007-10-03 | 花王株式会社 | Skin cosmetics |
| JP4787461B2 (en) * | 2003-05-15 | 2011-10-05 | 花王株式会社 | Skin cosmetics |
| KR100678864B1 (en) * | 2005-08-30 | 2007-02-05 | 주식회사 코리아나화장품 | Cosmetic composition for skin whitening comprising cnidium officinale extract and carnitine as active ingredient |
| KR100678865B1 (en) * | 2005-08-30 | 2007-02-05 | 주식회사 코리아나화장품 | Cosmetic composition for skin whitening comprising ramulus mori extract and carnitine as active ingredient |
-
1995
- 1995-04-18 JP JP11776095A patent/JP3229517B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JPH08291039A (en) | 1996-11-05 |
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