KR20090070089A - Composition for prevention of hair loss and stimulation of hair growh - Google Patents

Abstract

A composition for promoting hair growth, which contains a mixture of kappa tripeptide, salicylic acid, tocopheryl acetate and nicotinic acid amide is provided to promote the hair growth by providing the nutrition and maintain the hair growth phase. A composition for promoting hair growth comprises a mixture of kappa tripeptide, salicylic acid, tocophrol acetate, nitotinic acid amide in a weight ratio of 0.5-10: 1-15: 10-30: 1-10 as an active ingredient. The kappa tripeptide is obtained by reacting a glycine, histidine, and lysine and reacting tripeptide(Gly-His-Lys) with copper chloride. The salicylic acid is included in o-oxybenzoic acid and denoted by the chemical formula C7H6O3. The tocopheryl acetate is denoted by the chemical formula C31H52O3. The nicotinamide is one of the vitamin B complex included in a pyridine-3-carboxyamide and denoted by the chemical formula C6H6N2O. The composition is used in an external skin preparation, cosmetic product or cleansing agent. The external skin preparation is used in a form of powder, gel, ointment, cream, liquid, or aerosol. The cosmetic product is used in a form of nutrition cream, astringent, skin softener, lotion, essence, nutrition gel, massage cream or powder formulation. The cleansing agent is used in a form of soap, shampoo, or rinse.

Description

Composition for prevention of hair loss and stimulation of hair growh}

The present invention relates to a hair growth promoting composition comprising a mixture of kappa tripeptides, salicylic acid, tocopherol acetate and nicotinic acid amide as an active ingredient.

The hair of the human body is about 100,000 to 150,000 pieces, and each hair is repeatedly grown and degenerated through different cycles. The hair has a growing period of growth (anagen), a catagen that slows metabolism while maintaining the shape of the hair and the hair papilla atrophy, the hair follicles shrink gradually, and the hair roots are pushed upwards to make the hair follicles smaller ( The three-phase cycle of telogen is repeated. The hair cycle and lifespan can vary according to various conditions such as nutritional status, medical history, heredity, constitution, hormone secretion or aging. Not.

However, in recent years, a growing number of people are suffering from hair loss due to changes in diet, social stress, etc., and the age is also decreasing, and the hair loss population of women is also increasing.

The most widely used agent for the treatment or prevention of such alopecia is the external minoxidil approved by the US FDA. The minoxidil was a high blood pressure treatment drug developed for the purpose of lowering blood pressure, but the hair growth phenomenon appeared as a side effect of use, and now it is more famous as a hair growth agent. Although the mechanism of minoxidil's hair growth is not known exactly, it is thought to promote hair growth by nourishing hair roots by increasing blood flow through vasodilating effect. In addition, a 1 mg tablet is currently on the market after approval from the FDA for the treatment of androgenetic alopecia.

However, the minoxids are expensive and side effects are reported as the occurrence of side effects have been limited, and even the male side effects of the tablets have also been reported.

It is an object of the present invention to provide a composition for promoting hair growth, which contains an active ingredient which shows a much higher effect than a conventional component having a hair growth promoting effect.

The present invention provides a composition for promoting hair growth containing a mixture of kappatripeptides, salicylic acid, tocopherol acetate and nicotinamide as an active ingredient.

Hereinafter, the present invention will be described in detail.

The hair growth promoting composition of the present invention is characterized by containing a mixture of kappatripeptides, salicylic acid, tocopherol acetate and nicotinamide as an active ingredient.

Kappatripeptides can be obtained by reacting copper chloride with copper chloride to tripeptide (Gly-His-Lys) obtained by reacting Glycine, Histidine, and Lysine. It mainly protects tissue and prevents inflammation due to tissue damage. That is, when the tissue is damaged, it plays a role in healing and reconstructing the tissue and protecting the tissue, increasing biosynthesis of new collagen and elastin, and developing hair follicles and increasing the amount and thickness of subcutaneous fat of the skin.

Salicylic acid corresponds to o-oxybenzoic acid and is represented by the formula C7H6O3. The salicylic acid has antibacterial anti-inflammatory effect, anti-dandruff effect, and is also useful for exfoliation.

Tocopheryl Acetate (Tocopheryl Acetate) is represented by the formula C31H52O3, is involved in the smooth nutrition of the scalp, regulates sebum of the scalp, and has the function of activating hair follicle cells.

Nicotinamide is one of the vitamin B complexes corresponding to pyridine-3-carboxyamide and is represented by the formula C6H6N2O, also referred to as nicotinamide or niacinamide. The nicotinic acid amide has a significant improvement in sebum secretion or seborrheic dandruff and those sensitive to itching.

Hair products containing each of these components have been commercialized recently, but there is no hair product containing a mixture of the four components as an active ingredient.

The present inventors have a unique mechanism of action in each component that exhibits effects such as hair growth promoting effect or hair follicle vasodilation, and when various components act properly on the mechanism of action, the effect of promoting hair growth or the like is increased or antagonized. In the case of a composition containing kappatripeptides, salicylic acid, tocopherol acetate and nicotinamide at the same time through a large number of combinations of each component having a hair growth promoting effect and the like, which are expected to be effective, It was found that the hair growth promoting effect is much higher than that of each component.

Accordingly, the present invention provides a composition for promoting hair growth containing a mixture of kappatripeptides, salicylic acid, tocopherol acetate and nicotinamide as an active ingredient.

In the present invention, the 'capatrippeptide' can be prepared and used according to a known method, or a commercially available one can be purchased and used, and also includes derivatives having the same efficacy as the capatrippeptide.

In the present invention, 'salicylic acid' may be prepared and used according to a known method, or a commercially available one may be purchased and used, and also includes derivatives having the same efficacy as salicylic acid.

In the present invention, 'tocopherol acetate' may also be prepared and used according to a known method, or a commercially available one may be used and may include a derivative having the same efficacy as tocopherol acetate.

In the present invention, 'nicotinic acid amide' may be prepared and used according to a known method, or a commercially available one may be purchased and used.

Since the mixture of kappatrippeptide, salicylic acid, tocopherol acetate and nicotinamide is excellent in hair growth effect compared to a mixture of one to three of the above components, the composition according to the present invention containing the mixture as an active ingredient is It is useful as a composition for promoting hair growth.

In the present invention, the 'hair growth promoting composition' is a composition containing the mixture according to the present invention as an active ingredient, a composition having an effect of promoting the growth phase induction of the hair, or necessary for hair growth through the expansion of blood vessels around the hair follicles. It means a composition for supplying nutrients to maintain the growth phase of the hair.

In the present invention, the 'mixture' is a mixture of kappatripeptides, salicylic acid, tocopherol acetate and nicotinic acid amide, each of which is sequentially contained in the composition, each component is mixed in the composition Includes all that is contained.

The mixture may be a mixture of capatrippeptide: salicylic acid: tocopherol acetate: nicotinic acid amide in a ratio of 0.5 to 10: 1 to 15: 10 to 30: 1 to 10, preferably, capatrippeptide: salicylic acid : The weight ratio of tocopherol acetate: nicotinic acid amide may be mixed in a ratio of 1 to 7: 2 to 10: 15 to 25: 1 to 7. When the amount below the recommended minimum amount of each component is used, the effect of promoting growth of hair decreases due to mutual synergy. On the other hand, when the amount above the recommended maximum amount of each component is used, the effect of hair growth is directly proportional to the increase in the content of use. It is not increasing and may not be commercially suitable because the price of the raw material is too expensive.

In addition, the content of the mixture may be included in an amount of 0.02 to 10% by weight relative to the total weight of the composition.

According to the present invention, a composition for promoting hair growth containing a mixture consisting of kappa tripeptides, salicylic acid, tocopherol acetate and nicotinamide can be used as an external preparation for skin growth, a cosmetic for hair, a hair cleanser, and the like. Supplementary ingredients, such as anti-dandruff, keratin softeners, softeners, and moisturizers, may be used to reinforce the hair growth promoting effect of the composition and to impart additional functions suitable for use by alopecia patients, unless they have a detrimental effect. Can be added. Examples of auxiliary components, such as the anti-dandruff agent, keratin softener, coolant, and humectant, which are blended with the conventional hair loss prevention agent and hair growth promoter, may be exemplified by hinkitthiol, capsicum tink, pyroxtonolamine, L-menthol, and the like. These auxiliary ingredients can be used in such a range that the formulation can be maintained without disturbing the effect of the main ingredient. Preferably each of the components may be added in an amount of 0.001 to 0.1% by weight based on the total weight of the composition.

The composition for promoting hair growth containing a mixture of kappatrippeptide, salicylic acid, tocopherol acetate, and nicotinamide as an active ingredient of the present invention is that each component included in the mixture of the present invention is a safe substance for human or skin. It can be used as a skin external preparation.

The formulation of the external preparation for skin is not particularly limited. For example, it may have a formulation such as powder, gel, ointment, cream, liquid, aerosol, or the like.

In addition, the composition for promoting hair growth according to the present invention can be used as a cosmetic. The formulation of the cosmetic is not particularly limited, and may have, for example, a formulation such as a nourishing cream, astringent lotion, a flexible lotion, a lotion, an essence, a nourishing gel, a general ointment, a massage cream or a powder. When used as the cosmetic, the composition according to the present invention may be added to the material selected arbitrarily according to the formulation or purpose of use of the cosmetic. For example, purified water, oil, surfactants, moisturizers, higher alcohols, thickeners, chelating agents, pigments, fatty acids, antioxidants, preservatives, waxes, pH adjusters, flavoring agents and the like can be added.

The oils include mineral oil, cyclomethicone, squalane, octyldodecyl myristate, olive oil, macadamia nut oil, glycerol octanoate, castor oil, ethylhexyl isononanoate, dimethicone, cyclopentasiloxane, Sunflower seed oil and the like can be used.

The surfactants include sorbitan sesquinolate, polysorbate 60, glyceryl stearate, lipophilic glyceryl stearate, sorbitan oleate, sorbitan stearate, die-cetyl phosphate, sorbitan stearate / Sucrose cocoate, glyceryl stearate / polyethylene glycol-100 stearate, ceteareth-6 oleate, arachidyl alcohol / behenyl alcohol / arachidyl glucoside. Polypropylene glycol-26-butes-26 / polyethylene glycol-40 hydrogenated castor oil and the like can be used.

As the moisturizing agent, glycerin, sorbitol, propylene glycol, butylene glycol, hexylene glycol, diglycerin, betaine, glycerin-26, methylgluse-20 and the like may be used.

Cetyl alcohol, stearyl alcohol, octyldodecanol, isostearyl alcohol and the like may be used as the higher alcohol.

Xanthan gum, carbomer, magnesium aluminum silicate, cellulose gum, dextrin palmitate may be used as the thickener.

As the chelating agent, disodium idieti, tetrasodium idieti and the like may be used.

As the dye, Blue No. 1, Red No. 40, Yellow No. 4, Yellow No. 5, etc. may be used.

As the fatty acid, stearic acid, mystic acid, palmitic acid, isostearic acid, lauric acid, or the like may be used.

Tocopheryl acetate, butylated hydroxytoluene, etc. may be used as the antioxidant.

As the preservative, methyl paraben, butyl paraben, propyl paraben, phenoxyethanol, imidazolidinyl urea, chlorphenesin and the like may be used.

Carnauba wax, candenilla wax, beeswax, braze and the like may be used as the wax.

As the pH adjusting agent, triethanolamine, citric acid, or the like may be used.

As the fragrance, natural fragrance, combination fragrance, or the like may be used.

In addition, the hair growth promoting composition according to the present invention can be used as a cleaning agent. The formulation of the detergent is not particularly limited. For example, it may be a formulation of solid soap, liquid soap, shampoo, rinse, and the like.

As described above, the composition containing the mixture of kappatripepti, salicylic acid, tocopherol acetate and nicotinic acid amide according to the present invention exhibits a strong hair growth promoting effect, so that it can be used as an external preparation for skin, cosmetics, cleaning agents, etc. It can be usefully used.

Hereinafter, the present invention will be described in more detail with reference to Examples and Experimental Examples. However, the following examples are illustrative of the present invention, and the contents of the present invention are not limited by the examples.

<Example>

Each component was warmed and solubilized by using the components and the formulation shown in Table 1 below to prepare a hair lotion type hair restorer. Salicylic acid (Duksan), tocopherol acetate (DSM, Hauptstrasse 4, CH-4334 Sisseln, Switzerland), nicotinic acid amide (Western drugs, F-271 (A) Mewar Industrial Area, Madri) were purchased and other ingredients And the compounding amount is as follows.

ingredient Example Comparative example One One 2 3 Kappatripeptide-1 0.2 0.2 0.2 - Salicylic acid 0.50 0.50 - 0.50 Tocopherol Acetate 2.00 - 2.00 2.00 Nicotinic acid amide 0.30 0.30 0.30 0.30 Polysorbate 20 1.50 1.50 1.50 1.50 Polysorbate 60 3.50 3.50 3.50 3.50 Methylgluses-20 sesquistearate 5.00 5.00 5.00 5.00 Arginine 0.2 0.2 0.2 0.2 Paraoxybenzoic Acid Methyl 0.1 0.1 0.1 0.1 Paraoxybenzoic acid propyl 0.1 0.1 0.1 0.1 Purified water

 Test Example 1 Human Hair Growth Effect Test

Sixty male and female alopecia patients were divided into six groups, each group having similar types and severities, and the efficacy of each group was evaluated after treating the hair repellent composition prepared in Example 1 and Comparative Examples 1-3. . Scalp administration was performed twice a day for 6 months, and hair growth was evaluated after 3 months and 6 months.

The evaluation criteria were evaluated as follows, and the test results are shown in Table 2.

1. Highly effective-newborn hair is visible (hair growth).

2. Moderate effect-Newborn hair is visible (down).

3. Slightly effective-The number of hair loss is reduced.

4. No effect-no change is seen.

Example Comparative example One One 2 3 Newborn hair (bristle) 3 months later 6 2 One 0 6 months later 7 One One 0 Newborn hair (down) 3 months later 2 One One 0 6 months later One One One 0 Reduction of hair loss 3 months later 2 2 One 0 6 months later 2 2 One 0 No change 3 months later 0 5 7 10 6 months later 0 6 7 10

As can be seen from the results of Table 2, the hair regrowth of Example 1 according to the present invention contains the kappatripeptides activating the hair follicles and salicylic acid, tocopherol, nicotinic acid amide to supply hair follicle cells. Although it appeared in the month and continued excellently at 6 months, it can be seen that the case of not containing all four components, such as the kappatripepti of the comparative example, did not have a great hair growth effect.

Claims (8)

A composition for promoting hair growth containing a mixture of kappa tripeptides, salicylic acid, tocopherol acetate and nicotinic acid amide as an active ingredient. According to claim 1, wherein the mixture is kappa tripeptides salicylic acid: tocopherol acetate: nicotinic acid amide weight ratio of 0.5 to 10: 1 to 15: 10 to 30: 1 to 10 is mixed to promote hair growth Composition. The method of claim 1, wherein the mixture is characterized in that the weight ratio of kappatrippeptide: salicylic acid: tocopherol acetate: nicotinic acid amide is mixed in a ratio of 1 to 7: 2 to 10: 15 to 25: 1 to 7 Composition. The composition for promoting hair growth according to claim 1, wherein the content of the mixture is contained in an amount of 0.02 to 10% by weight based on the total weight of the composition. The composition for promoting hair growth according to any one of claims 1 to 4, wherein the composition is used as any one selected from the group consisting of an external preparation for skin, a cosmetic and a cleaning agent. The composition for promoting hair growth according to claim 5, wherein the external preparation for skin has a formulation selected from the group consisting of powder, gel, ointment, cream, liquid, and aerosol. According to claim 5, The cosmetic composition for promoting hair growth having a formulation selected from the group consisting of nourishing cream, astringent lotion, flexible lotion, lotion, essence, nutrition gel, common ointment, massage cream and powder. The hair growth promoting composition of claim 5, wherein the detergent has a formulation selected from the group consisting of soap, shampoo, and rinse.