KR20240001370A - Composition for promoting hair growth - Google Patents

Abstract

The present invention relates to a composition for promoting hair growth. More specifically, the composition for promoting hair growth contains Goniothalamin, a natural product derived from the genus Goniothalamus , as an active ingredient and can promote hair length growth.

Description

Composition for promoting hair growth {COMPOSITION FOR PROMOTING HAIR GROWTH}

The present invention relates to a composition for promoting hair growth.

Alopecia, in which hair falls out from the scalp, is caused by various factors, including internal factors such as genetic constitution or the action of male hormones, or external factors such as mental stress in daily life and accumulation of lipid peroxide in the scalp. It is known that these factors are involved in a complex manner, causing hair loss symptoms. Recently, hair loss in young people, including male pattern baldness as well as non-chronic hair loss in women, is gradually spreading, and many types of hair growth or hair growth agents are on the market to improve this hair loss phenomenon.

Hair growth can be divided into anagen phase, catagen phase, and telogen phase. During the anagen phase, hair continues to grow as active cell division occurs in the hair bulb, which is the base of the hair follicle, but during the catagen phase, the hair bulb It rapidly atrophies and the growth activity of the hair follicles stops, and in the resting phase, the growth activity of the hair follicles completely stops. At this time, new anagen hair is formed at the base of the telogen hair follicle, and the existing telogen hair is pushed out by the new anagen hair or is detached by a mechanical action such as combing.

Therefore, in order to achieve effective hair loss prevention and hair growth effects, it must be possible to simultaneously exert a growth-inducing effect that promotes the transition from the telogen phase to the growth phase and a catagen-inhibiting effect that delays the transition from the growth phase to the catagen phase.

The main ingredients used in commercially available hair growth or hair restorers include vasodilators such as capronium chloride and minoxidil to circulate sufficient blood to the scalp, and to inhibit the action of male hormones that attach to the dermal papilla and cause hair to fall out. There are female hormone agents such as estrogen, estragiol, and progesterone, or male hormone activation inhibitors such as pentadecanoic acid and finasteride. For example, there are two types of drugs approved by the U.S. Food and Drug Administration (FDA) for the treatment of hair loss. Minoxidil, a topical treatment, works by dilating blood vessels, and Propecia, an oral drug, works by suppressing the activation of male hormones, such as finasteride. It is widely used as an agent with excellent hair loss prevention effects.

However, in the case of minoxidil, not only does it rely on imports of all raw materials from overseas, but it also takes a long time to be absorbed into the skin, hair loss recurs when use is discontinued, and there is little treatment effect after hair loss has completely progressed. Serious problems with existing products are being highlighted, including reports that Propecia is prescribed only to adult men and can cause decreased sperm count and sexual dysfunction. Moreover, since the mechanism of action of most existing hair loss treatments is closely related to male hormones, they pose serious problems such as not being effective in women or causing birth defects. Therefore, due to these problems, interest has recently been focused on natural ingredients for promoting hair growth and preventing hair loss.

Although various substances have been developed for the purpose of hair growth efficacy, there is no known research on the hair growth efficacy of Goniothalamin. Goniothalamin is a component derived from the genus Goniothalamus, and research on its anti-cancer or anti-inflammatory properties is known ( ACS Biomater. Sci. Eng. 2020, 6, 5, 2929-2942).

ACS Biomater. Sci. Eng. 2020, 6, 5, 2929-2942

Accordingly, in order to confirm whether Goniothalamin, a component derived from the genus Goniothalamus, has a hair growth effect, the present inventors prepared a composition containing Goniothalamin as an active ingredient, and found that the composition has a hair growth promoting effect that induces hair length growth. It was confirmed that it represents .

Therefore, an object of the present invention is to provide a composition for promoting hair growth containing goniothalamin as an active ingredient.

In order to achieve the above object, the present invention provides a composition for promoting hair growth containing goniothalamin (Goniothalamin) as an active ingredient.

The composition for promoting hair growth according to the present invention contains goniotalamine as an active ingredient and can exhibit a hair growth promoting effect that induces hair length growth.

Figure 1 is a graph showing measurement results for hair growth promoting efficacy according to goniothalamin concentration.

Hereinafter, the present invention will be described in detail.

Composition for promoting hair growth

The present invention relates to a composition for promoting hair growth containing goniothalamin as an active ingredient.

The goniotalamin may be represented by the following formula (1):

<Formula 1>

.

In addition, the goniotalamine is a natural product and can reduce the probability of side effects caused by synthetic substances.

In addition, the goniotalamine is a single substance and can be used at the correct concentration to achieve the desired effect. On the other hand, in the case of extracts, the content of the active ingredient in the extract may vary depending on the extraction method or extraction conditions, so it may be difficult to predict the exact content of the active ingredient in the extract, so goniotalamin in the form of a single substance It may be desirable to use .

In the present invention, the content of the goniotalamine may be 0.01% by weight to 5% by weight based on the total weight of the composition for promoting hair growth, specifically, 0.01% by weight or more, 0.05% by weight or more, or 0.1% by weight. It may be more than 2% by weight, or less than 2% by weight, less than 3% by weight, less than 4% by weight, or less than 5% by weight. If the goniotalamine content is less than 0.01% by weight, the hair growth promotion effect may be reduced, and if it is more than 5% by weight, the feeling of use may be reduced.

In the present invention, the composition for promoting hair growth may be in a liquid form. When the composition for promoting hair growth is in a liquid form compared to a gel or solid form, absorption of the goniotalamine can be further promoted.

In the present invention, the concentration of goniotalamin may be 4 μg/ml to 15 μg/ml. Specifically, the concentration of the goniothalamin may be 4 μg/ml or more, 5 μg/ml or more, or 8 μg/ml or more, and may be 10 μg/ml or less, 12 μg/ml or less, or 15 μg/ml or less. there is. If the concentration of goniotalamine is less than 4 ㎍/㎖, the hair growth promotion effect may be reduced, and if it is more than 15 ㎍/㎖, the feeling of use may be reduced.

In the present invention, the composition for promoting hair growth may induce hair growth in length.

In general, hair growth means the growth of new hair, and hair loss prevention means preventing hair that has already grown from falling out. The composition for promoting hair growth of the present invention is a functional composition that is different from the composition for preventing hair growth or hair loss.

In the present invention, the composition for promoting hair growth may be a composition for external application to the skin.

The external skin agent is a general term that can include anything applied outside the skin, and can include cosmetics and pharmaceuticals of various formulations.

In the present invention, the composition for promoting hair growth may be a cosmetic composition.

The cosmetic composition includes, for example, softening lotion, astringent lotion, nourishing lotion, nourishing cream, massage cream, eye cream, eye essence, essence, cleansing cream, cleansing lotion, cleansing foam, cleansing water, pack, powder, body lotion. , body cream, body essence, body cleanser, hair dye, shampoo, rinse, hair straightener, hair dye, ointment, gel, cream, patch, spray, powder, and skin adhesive type, but is not limited to these. In addition, in each formulation, other ingredients in addition to the above-mentioned essential ingredients can be appropriately selected and mixed by a person skilled in the art according to the type or purpose of use of other external preparations.

Additionally, the cosmetic composition may be provided in any formulation suitable for topical application. For example, it can be provided in the form of a solution, an emulsion obtained by dispersing the oil phase in the water phase, an emulsion obtained by dispersing the water phase in the oil phase, suspension, solid, gel, powder, paste, microneedle, foam, or aerosol composition. there is. Compositions of this dosage form can be prepared according to conventional methods in the art.

In addition, the cosmetic composition may additionally contain functional additives and ingredients included in general cosmetic compositions. The functional additive may include ingredients selected from the group consisting of water-soluble vitamins, oil-soluble vitamins, polymer peptides, polymer polysaccharides, sphingolipids, and seaweed extract.

Additionally, the cosmetic composition may contain other ingredients that can preferably have a synergistic effect on the main effect within a range that does not impair the main effect. For example, the cosmetic composition may further include moisturizers, emollients, surfactants, ultraviolet absorbers, preservatives, disinfectants, antioxidants, pH adjusters, organic and inorganic pigments, fragrances, cooling agents, or antiperspirants. The mixing amount of the above ingredients can be easily selected by a person skilled in the art within the range that does not impair the purpose and effect of the present specification, and the mixing amount may be 0.001 to 10% by weight, specifically 0.01 to 3% by weight, based on the total weight of the composition. there is.

In the present invention, the composition for promoting hair growth may be a food composition.

The formulation of the food composition is not particularly limited, but may be formulated into, for example, tablets, granules, pills, powders, liquids such as drinks, caramels, gels, bars, tea bags, etc. In addition to the active ingredients, the food composition of each formulation can be appropriately selected and mixed by a person skilled in the art according to the formulation or purpose of use with ingredients commonly used in the field, and when applied simultaneously with other raw materials, a synergistic effect can occur.

In addition, the food composition contains various nutrients, vitamins, minerals (electrolytes), flavoring agents such as synthetic and natural flavors, colorants and enhancers (cheese, chocolate, etc.), pectic acid and its salts, alginic acid and its salts, It may include organic acids, protective colloidal thickeners, pH adjusters, stabilizers, preservatives, glycerin, alcohol, carbonating agents used in carbonated beverages, etc. Additionally, the food compositions may include natural fruit juice and pulp for the production of fruit juice beverages and vegetable beverages. These ingredients can be used independently or in combination. The ratio of these additives is not that important, but is generally included in the range of 0 to about 50 parts by weight per 100 parts by weight of the composition according to one embodiment.

In the present invention, the composition for promoting hair growth may be a pharmaceutical composition.

The pharmaceutical composition may be administered orally, parenterally, rectally, topically, transdermally, intravenously, intramuscularly, intraperitoneally, subcutaneously, etc. Dosage forms for oral administration may be tablets, pills, soft and hard capsules, granules, powders, fine granules, solutions, emulsions, or pellets, but are limited thereto. That is not the case. Formulations for parenteral administration may be solutions, suspensions, emulsions, gels, injections, drops, suppositories, patches, or sprays, but are not limited thereto. The formulation can be easily prepared according to conventional methods in the field, and contains surfactants, excipients, wetting agents, emulsification accelerators, suspending agents, salts or buffers for adjusting osmotic pressure, colorants, flavorings, stabilizers, preservatives, preservatives or Other commonly used supplements may be additionally included.

Preferred examples are presented below to aid understanding of the present invention. However, the following examples are merely illustrative of the present invention, and it is obvious to those skilled in the art that various changes and modifications are possible within the scope and spirit of the present invention. , it is natural that such changes and modifications fall within the scope of the attached patent claims.

Experimental example: Evaluation of hair growth promotion efficacy according to concentration of Goniothalamin

Using the “Two-Cell Assemblage” Assay (“Two-Cell Assemblage” Assay: A Simple in vitro Method for Screening Hair Growth-Promoting Compounds (Front Cell Dev Biol. 2020 Nov 24;8:581528), the concentration of Goniothalamin The hair growth promoting efficacy was evaluated.

“Two-Cell Assemblage” Assay is an evaluation method that imitates the hair growth of actual hair follicles by culturing dermal papilla (DP) cells and outer root sheath (ORS) cells, which make up hair follicles, together. am. In other words, the length growth of the “Two-Cell Assemblage” structure has a mechanism similar to actual hair follicle growth, and is being used as a new method of evaluating hair growth promotion efficacy.

5,000 hair follicle dermal papilla cells (Kyungpook National University Industry-Academic Cooperation Foundation) were seeded in an ultra-low attachment 96-well plate to form 3D spheroids. After 24 hours, 5,000 outer root sheath cells (Kyungpook National University Industry-Academic Cooperation Foundation) were added together with the Goniothalamin to create a two-cell assembly structure, and cultured for 5 days at 37°C and 5% CO ₂ conditions. After culturing for 5 days, hair length growth was measured using a microscope (OLYMPUS, SZX16). At this time, the Goniothalamin (Chemface, CFN97803) was treated at different concentrations as shown in Table 1 below.

Concentration (unit: ㎍/㎖) Comparative Example 1
(control) Example 1 Example 2 Example 3 Example 4 goniothalamin 0 1.25 2.5 5 10

Figure 1 is a graph showing measurement results for hair growth promoting efficacy according to goniothalamin concentration. The significance of the experiment was confirmed by Student's t test.

Referring to Figure 1, it can be seen that as the concentration of Goniothalamin increases, the length of the grown hair increases and the hair growth promoting effect is excellent.

Although the present invention has been described above with limited examples and drawings, the present invention is not limited thereto, and the technical idea of the present invention and the following description will be provided by those skilled in the art in the technical field to which the present invention pertains. Of course, various modifications and variations are possible within the scope of equivalence of the patent claims.

Claims (7)

A composition for promoting hair growth containing goniothalamin as an active ingredient. According to paragraph 1,
The goniotalamine is included in the composition at a concentration of 4 ㎍/㎖ to 15 ㎍/㎖, a composition for promoting hair growth. According to paragraph 1,
The composition is a composition for promoting hair growth, which promotes hair length growth. According to paragraph 1,
The composition is a composition for promoting hair growth, which is a composition for external application to the skin. According to paragraph 1,
The composition is a food composition, a composition for promoting hair growth. According to paragraph 1,
The composition is a cosmetic composition, a composition for promoting hair growth. According to paragraph 1,
The composition is a pharmaceutical composition, a composition for promoting hair growth.