JP2744485B2 - Whitening cosmetics - Google Patents
Whitening cosmeticsInfo
- Publication number
- JP2744485B2 JP2744485B2 JP27224989A JP27224989A JP2744485B2 JP 2744485 B2 JP2744485 B2 JP 2744485B2 JP 27224989 A JP27224989 A JP 27224989A JP 27224989 A JP27224989 A JP 27224989A JP 2744485 B2 JP2744485 B2 JP 2744485B2
- Authority
- JP
- Japan
- Prior art keywords
- ascorbic acid
- whitening
- water
- skin
- soluble
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Cosmetics (AREA)
Description
【発明の詳細な説明】 〔産業上の利用分野〕 本発明は、保存安定性及び美白効果に優れた美白化粧
料に関する。The present invention relates to a whitening cosmetic having excellent storage stability and whitening effect.
一般にシミ、ソバカス、日焼けなどに見られる皮膚の
色素沈着は、皮膚内に存在するチロシンがチロシナーゼ
の作用により酸化されてメラニンとなり、このメラニン
が過剰に生成することに基因するとされている。この色
素沈着を予防或いは治療することによって元の色白の肌
を維持することを目的に、従来よりＬ−アスコルビン酸
と種々の高級脂肪酸、リン酸及び硫酸とのエステル類を
配合してなる美白化粧料が提案されている。It is said that the pigmentation of the skin, which is generally observed in spots, freckles, sunburn, and the like, is caused by the oxidation of tyrosine present in the skin into melanin by the action of tyrosinase, and excessive production of melanin. In order to maintain the original fair skin by preventing or treating this pigmentation, a whitening cosmetic comprising a conventional mixture of esters of L-ascorbic acid with various higher fatty acids, phosphoric acid and sulfuric acid. Fees have been proposed.
しかし、これらの美白化粧料中に含有する水溶性Ｌ−
アスコルビン酸のエステル類は、単独では保存安定性と
美白効果とを同時に充分満足できる美白化粧料を得るこ
とは困難である。However, the water-soluble L-
Ascorbic acid esters alone are difficult to obtain a whitening cosmetic which can sufficiently satisfy both storage stability and whitening effect at the same time.
また、Ｌ−アスコルビン酸誘導体に関しても単独では
十分な保存安定性と美白効果が得られていないのが現状
である。Further, at present, sufficient storage stability and whitening effect have not been obtained by using the L-ascorbic acid derivative alone.
本発明は、保存安定性と美白効果に優れた美白化粧料
を提供することを目的としている。An object of the present invention is to provide a whitening cosmetic having excellent storage stability and whitening effect.
本発明者らは、上述の事情に鑑み鋭意研究した結果、
特定のＬ−アスコルビン酸誘導体と水溶性アルコルビン
酸エステル誘導体とを配合してなる美白化粧料は保存
安定性が良好であると共に生成メラニン淡色化作用を
有し表皮の新陳代謝を促進して更に美白効果を高める
ことを見出し本発明を完成した。The present inventors have conducted intensive studies in view of the above circumstances,
A whitening cosmetic comprising a specific L-ascorbic acid derivative and a water-soluble ascorbic acid ester derivative has good storage stability, has a melanin lightening effect, promotes metabolism of the epidermis, and further has a whitening effect. And completed the present invention.
本発明は下記一般式 （式中Ｒは炭素数１〜22のアルキル基又はアルケニル
基） で表わされるＬ−アスコルビン酸誘導体と水溶性アスコ
ルビン酸エステル誘導体とを配合することを特徴とする
美白化粧料である。The present invention has the following general formula (Wherein R is an alkyl or alkenyl group having 1 to 22 carbon atoms). A whitening cosmetic comprising a mixture of an L-ascorbic acid derivative represented by the formula: and a water-soluble ascorbic acid ester derivative.
本発明に用いられるＬ−アスコルビン酸誘導体は公知
の物質であって、例えば特開昭58−57373号公報に記載
の製造方法等により容易に製造することが可能である。
Ｌ−アスコルビン酸誘導体のアルキル基又はアルケニル
基はその炭素数が１〜22の範囲であればよく、その炭素
数によって水溶性乃至油溶性を呈する。本発明に於いて
は、その特性にこだわることなくＬ−アスコルビン酸誘
導体の一種以上を用いることができる。即ち水溶性のも
のと油溶性のものを組み合わせて用いてもよい。The L-ascorbic acid derivative used in the present invention is a known substance, and can be easily produced by, for example, the production method described in JP-A-58-57373.
The alkyl group or alkenyl group of the L-ascorbic acid derivative may have a carbon number in the range of 1 to 22, and exhibits water solubility or oil solubility depending on the carbon number. In the present invention, one or more kinds of L-ascorbic acid derivatives can be used without being particular about the characteristics. That is, a water-soluble substance and an oil-soluble substance may be used in combination.
Ｌ−アスコルビン酸誘導体の配合量は、美白化粧料組
成物の総量を基準として好ましくは0.1〜10.0重量％
（以下wt％と略記する）、更に好ましくは1.0〜5.0wt％
である。配合量が0.1wt％未満では本発明の目的とする
効果に充分でなく、10wt％を超えてもその増加分に見合
った効果の向上は望めず、使用時の感触が悪くなり易く
なったり、個々の剤型を安定に保持し難くなるので好ま
しくない。The compounding amount of the L-ascorbic acid derivative is preferably 0.1 to 10.0% by weight based on the total amount of the whitening cosmetic composition.
(Hereinafter abbreviated as wt%), more preferably 1.0 to 5.0 wt%
It is. If the compounding amount is less than 0.1 wt%, the effect intended by the present invention is not sufficient, and if it exceeds 10 wt%, the effect corresponding to the increase cannot be expected, and the feel at the time of use tends to deteriorate, It is not preferable because it is difficult to stably maintain individual dosage forms.
本発明に用いられる水溶性アスコルビン酸エステル誘
導体とは、アスコルビン酸のリン酸エステル塩や硫酸エ
ステル塩などのように水溶性のものをさし、例えば、Ｌ
−アスコルビン酸リン酸エステルナトリウム塩,L−アル
コルビン酸リン酸エステルカリウム塩、Ｌ−アスコルビ
ン酸リン酸エステルマグネシウム塩、Ｌ−アスコルビン
酸リン酸エステルカルシウム塩,L−アスコルビン酸リン
酸エステルアルミニウム塩,L−アスコルビン酸硫酸エス
テルナトリウム塩,L−アスコルビン酸硫酸エステルカリ
ウム塩,L−アスコルビン酸硫酸エステルマグネシウム
塩,L−アスコルビン酸硫酸エステルカルシウム塩,L−ア
スコルビン酸硫酸エステルアルミニウム塩などが挙げら
れる。The water-soluble ascorbic acid ester derivative used in the present invention refers to a water-soluble one such as a phosphoric acid ester salt or a sulfate ester salt of ascorbic acid.
-Ascorbic acid phosphate sodium salt, L-ascorbic acid phosphate potassium salt, L-ascorbic acid phosphate magnesium salt, L-ascorbic acid phosphate calcium salt, L-ascorbic acid phosphate aluminum salt, L -Ascorbic acid sulfate sodium salt, L-ascorbic acid sulfate potassium salt, L-ascorbic acid sulfate magnesium salt, L-ascorbic acid sulfate calcium salt, L-ascorbic acid sulfate aluminum salt and the like.
水溶性アスコルビン酸エステル誘導体の配合量は美白
化粧料組成物の総量を基準して好ましくは0.1〜10重量
％、更に好ましくは１〜５重量％である。0.1重量％未
満では本発明の目的とする効果に充分でなく、10重量％
を超えても増加分に見合った効果の向上は望めず、使用
時の感触が悪くなり個々の剤型の物理化学的安定性が低
下し易くなるので好ましくない。The compounding amount of the water-soluble ascorbic acid ester derivative is preferably 0.1 to 10% by weight, more preferably 1 to 5% by weight, based on the total amount of the whitening cosmetic composition. If the amount is less than 0.1% by weight, the desired effect of the present invention is not sufficient, and 10% by weight
If the amount exceeds the range, the effect corresponding to the increase cannot be expected, and the feeling at the time of use is deteriorated, and the physicochemical stability of each dosage form is apt to be lowered, which is not preferable.
本発明の美白化粧料の剤型は、特に限定されるもので
なく、クリーム状、乳液状、ローション状、パウダー状
等々の通常の化粧料の剤型を適用することが出来る。ま
た、他の成分として、香料、防腐剤、着色料、皮膚栄養
剤などを本発明の目的を達成する範囲内で適宜配合し得
る。The dosage form of the whitening cosmetic composition of the present invention is not particularly limited, and a usual cosmetic dosage form such as cream, milky lotion, lotion, powder and the like can be applied. Further, as other components, a fragrance, a preservative, a coloring agent, a skin nutrition agent, and the like can be appropriately compounded within a range that achieves the object of the present invention.
以下、実施例にて本発明を説明する。 Hereinafter, the present invention will be described with reference to examples.
実施例に記載の保存安定性試験、メラニン形成抑
制試験、皮膚色明度回復試験、美白実用試験は下記
の通りに実施した。The storage stability test, melanin formation inhibition test, skin color brightness recovery test, and whitening practical test described in the examples were carried out as follows.
保存安定性試験 調整直後の試料と、温度が20℃、45℃の恒温室に３ヶ
月間保存した各々の試料を下記の方法にてチロシナーゼ
活性阻害率を測定した。Storage stability test The tyrosinase activity inhibition rate of the sample immediately after adjustment and each sample stored for 3 months in a thermostat at 20 ° C and 45 ° C were measured by the following method.
上記、３つの試料の値を比較してチロシナーゼ活性阻
害率の低減が少ない試料は、保存安定性が良好であると
評価した。By comparing the values of the above three samples, the sample with a small decrease in the tyrosinase activity inhibition rate was evaluated as having good storage stability.
（チロシナーゼ活性阻害率の測定方法） ハーディング−パッセィ（Harding−Passay）マウス
メラノーマから抽出した酵素チロシナーゼを使用し、そ
の酵素活性をドーパークロームの475nmの吸光度を測定
するフォトメトリー法によってしらべた。(Method of Measuring Tyrosinase Activity Inhibition Rate) Using an enzyme tyrosinase extracted from Harding-Passay mouse melanoma, the enzyme activity was examined by a photometric method for measuring absorbance at 475 nm of Dow's chroma.
各試料0.9mlを採取し、Ｌ−チロシン溶液（0.3mg/m
l）を1mlとマックルベイン氏の緩衝液（pH6.8）を1ml加
え、37℃の恒温水槽中で10分間インキュベートした後、
これにチロシナーゼ溶液（1mg/ml）を0.1ml加えてよく
撹拌し、37℃に保って10分後、475nmで吸光度（D1）を
測定する。加熱失活させたチロシナーゼを用いて同様に
反応させた吸光度（D2）および水のみを用いた対照試験
品の吸光度（D3）を測定し、次式からチロシナーゼ活性
阻害率を算出する。0.9 ml of each sample was collected, and the L-tyrosine solution (0.3 mg / m
l) and 1 ml of McClubane's buffer (pH 6.8) were added, and the mixture was incubated for 10 minutes in a 37 ° C constant temperature water bath.
To this, 0.1 ml of a tyrosinase solution (1 mg / ml) is added, and the mixture is stirred well. After maintaining at 37 ° C. for 10 minutes, the absorbance (D 1 ) is measured at 475 nm. The absorbance (D 2 ) of the reaction in the same manner using the tyrosinase inactivated by heat and the absorbance (D 3 ) of the control test product using only water are measured, and the tyrosinase activity inhibition rate is calculated from the following equation.
メラニン形成抑制試験 F1系黒色モルモット（雄、約８週令、平均体重350g）
の背部皮膚を刈毛後、脱毛クリームにより完全除毛し、
翌日より各試料を除毛部皮膚に毎日一回、4cm2当り0.2g
塗布し、閉塞貼布した。尚一試料に対して動物は一群10
匹使用した。 Melanin formation inhibition test F1 black guinea pig (male, about 8 weeks old, average weight 350g)
After shaving the back skin of the hair, the hair is completely removed with a depilatory cream,
Once a day from each sample to the cutter skin the following day, 4cm 2 per 0.2g
It was applied and closed. In addition, animals are in groups of 10 per sample
Used.
メラニン形成抑制効果の評価は、試験開始後１ケ月後
に実施し、高速分光色彩計を用いて塗布部の明度（YT）
と非塗布部の明度（Y0）との比の値（YT/Y0）で示し
た。また、評価は平均値で示した。Evaluation of the melanin formation inhibitory effect was performed one month after the start of the test, and the lightness (Y T ) of the coated part was measured using a high-speed spectral colorimeter.
And the value (Y T / Y 0 ) of the ratio of the non-coated portion to the lightness (Y 0 ). The evaluation was indicated by an average value.
皮膚色明度回復試験 被試験者20名の背部皮膚にUV−Ｂ領域の紫外線を最小
紅斑量の２倍量照射し、１週間の後、その照射部に試料
塗布部位と非塗布部位とを設定して各々の皮膚の基準明
度（Vo値、Vo′値）を測定した。引続いて塗布部位には
試料を１日１回ずつ３ケ月間連続塗布し、３、７、13週
間後の塗布部位及び非塗布部位の皮膚の回復明度（Vn
値、Vn′値）を測定して、第１表の判定基準により、皮
膚色の回復評価を実施した。Skin color lightness recovery test Irradiation of the UV-B region with twice the minimum erythema dose was applied to the back skin of 20 test subjects, and after one week, a sample application site and a non-application site were set in the irradiated area. Then, the reference brightness (Vo value, Vo 'value) of each skin was measured. Subsequently, the sample was continuously applied to the application site once a day for three months, and the skin recovery brightness (Vn) of the application site and the non-application site after 3, 7, and 13 weeks
, Vn 'value), and the skin color was evaluated for recovery according to the criteria shown in Table 1.
尚、皮膚の明度（Ｖ値）は高速分光色彩計で測定して
得られたマンセル値より算出した。また、評価は被試験
者20名の評価点の平均値で示した。The lightness (V value) of the skin was calculated from the Munsell value obtained by measuring with a high-speed spectral colorimeter. The evaluation was shown by the average of the evaluation points of 20 test subjects.
美白実用試験 シミ、ソバカス、日焼け等を訴える被試験者各20名の
顔面に試料を朝夕１回ずつ３ケ月間連続塗布した後の改
善効果を調査した。評価は（イ）シミ、（ロ）ソバカ
ス、（ハ）日焼けが各々改善されたと回答した被試験者
の数で示した。 Practical skin whitening test The improvement effect after applying the sample to the face of each of 20 test subjects complaining of spots, freckles, sunburn, etc. once in the morning and evening for 3 months was investigated. The evaluation was shown by the number of test subjects who answered that (a) spots, (b) freckles, and (c) sunburn were each improved.
実施例１〜５、比較例１〜７二層型ローション 下記の組成に於いて第２表左欄に示す通りにＬ−アス
コルビン酸誘導体と水溶性アスコルビン酸エステル誘導
体の種類及び配合量を変えて実施例及び比較例である二
層型ローションを調製して諸試験を実施した。その結果
を第２表右欄に示した。Examples 1 to 5 and Comparative Examples 1 to 7 Two-layer lotion In the following composition, the types and amounts of the L-ascorbic acid derivative and the water-soluble ascorbic acid ester derivative were changed as shown in the left column of Table 2. Various tests were carried out by preparing two-layer lotions as examples and comparative examples. The results are shown in the right column of Table 2.
（１）組成 （２）調製方法 （Ａ）成分の内油溶性のものは（Ｂ）成分（油相）中
に、また水溶性のものは（Ｃ）成分（水相）中に、必要
に応じて加熱して均一に溶解した。次いで（Ｂ）成分溶
液、（Ｃ）成分溶液を混合撹拌した後、容器に充填し
た。(1) Composition (2) Preparation method If necessary, the component (A) in oil-soluble form is heated in the component (B) (oil phase), and the water soluble form in the component (C) (aqueous phase). And dissolved uniformly. Next, the component solution (B) and the component solution (C) were mixed and stirred, and then filled in a container.
使用時には内容物を均一に振盪分散して使用した。 At the time of use, the contents were uniformly shaken and used.
（３）特性 第２表に示すごとく比較例２〜５の従来より知らてい
る水溶性Ｌ−アスコルビン酸エステル誘導体を配合した
二層型ローションは諸試験に於いて満足する結果を得ら
れなかった。一方、実施例１〜５の本発明の美白化粧料
に於いては前記諸試験の評価がすべて良好であった。(3) Properties As shown in Table 2, the two-layer lotions containing the conventionally known water-soluble L-ascorbic acid ester derivatives of Comparative Examples 2 to 5 failed to obtain satisfactory results in various tests. . On the other hand, in the whitening cosmetics of the present invention of Examples 1 to 5, all the evaluations of the above tests were good.
実施例６〜13、比較列８〜12スキンクリーム 実施例１と同様に、下記の組成に於いて種々の実施例
及び比較例のスキンクリームを調製して諸試験を実施し
た。その結果を第３表右欄に示した。Examples 6 to 13 and Comparative Rows 8 to 12 Skin Cream Similar to Example 1, skin creams of various Examples and Comparative Examples were prepared with the following compositions and various tests were performed. The results are shown in the right column of Table 3.
（１）組成 （２）調製方法 また水溶性のものは（Ｃ）成分中に混合し、（Ｂ）成
分と（Ｃ）成分を各々均一に加熱溶解して温度を80℃に
した。次いで、（Ｂ）成分中に（Ｃ）成分を注入撹拌混
合した後、撹拌しながら温度を30℃迄冷却した。(1) Composition (2) Preparation method In addition, the water-soluble one was mixed in the component (C), and the components (B) and (C) were uniformly heated and dissolved to a temperature of 80 ° C. Next, the component (C) was poured into the component (B), and the mixture was stirred, mixed, and then cooled to 30 ° C. with stirring.
（３）特性 第３表に示す如く、比較例８〜12に対して本発明の美
白化粧料である実施例６〜13は諸試験に於いて全て良好
な結果を示した。(3) Properties As shown in Table 3, Examples 6 to 13, which are the whitening cosmetics of the present invention, showed good results in various tests as compared with Comparative Examples 8 to 12.
〔発明の効果〕 以上記載の如く、水溶性アスコルビン酸エステル誘導
体及びＬ−アスコルビン酸誘導体を組み合わせた本発明
の美白化粧料が保存安定性及び美白効果に於いて顕著に
優れていることは明らかである。 [Effects of the Invention] As described above, it is clear that the whitening cosmetic composition of the present invention in which a water-soluble ascorbic acid ester derivative and an L-ascorbic acid derivative are combined is remarkably excellent in storage stability and whitening effect. is there.
Claims (1)
基） で表わされるＬ−アスコルビン酸誘導体と水溶性アスコ
ルビン酸エステル誘導体とを配合することを特徴とする
美白化粧料。1. The following general formula (Wherein R is an alkyl or alkenyl group having 1 to 22 carbon atoms). A whitening cosmetic comprising a L-ascorbic acid derivative represented by the formula: and a water-soluble ascorbic acid ester derivative.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP27224989A JP2744485B2 (en) | 1989-10-18 | 1989-10-18 | Whitening cosmetics |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP27224989A JP2744485B2 (en) | 1989-10-18 | 1989-10-18 | Whitening cosmetics |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH03133914A JPH03133914A (en) | 1991-06-07 |
| JP2744485B2 true JP2744485B2 (en) | 1998-04-28 |
Family
ID=17511214
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP27224989A Expired - Fee Related JP2744485B2 (en) | 1989-10-18 | 1989-10-18 | Whitening cosmetics |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2744485B2 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2988092B1 (en) * | 2012-03-16 | 2014-04-25 | Centre Nat Rech Scient | COMPLEXES OF VITAMIN C, NANOPARTICLES OF SAID COMPLEXES, PROCESSES FOR THEIR PREPARATION, COMPOSITIONS, COSMETIC USES, AND COSMETIC TREATMENT PROCESS |
| WO2015190505A1 (en) * | 2014-06-10 | 2015-12-17 | 味の素株式会社 | Cosmetic composition containing 3-o-alkyl-l-ascorbic acid or salt thereof |
-
1989
- 1989-10-18 JP JP27224989A patent/JP2744485B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JPH03133914A (en) | 1991-06-07 |
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