JP3517068B2 - Skin cosmetics - Google Patents
Skin cosmeticsInfo
- Publication number
- JP3517068B2 JP3517068B2 JP32108396A JP32108396A JP3517068B2 JP 3517068 B2 JP3517068 B2 JP 3517068B2 JP 32108396 A JP32108396 A JP 32108396A JP 32108396 A JP32108396 A JP 32108396A JP 3517068 B2 JP3517068 B2 JP 3517068B2
- Authority
- JP
- Japan
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- group
- skin
- carbon atoms
- ascorbic acid
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Description
【0001】[0001]
【発明の属する技術分野】本発明は、保存安定性に優
れ、色黒の皮膚を速やかに淡色化する、こじわを予防す
る、肌に潤いを与えるなどの効果に優れた皮膚化粧料に
関する。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a skin cosmetic which is excellent in storage stability, has excellent effects such as quickly lightening dark-skinned skin, preventing wrinkles, and moisturizing the skin.
【0002】[0002]
【従来技術及び発明が解決しようとする課題】従来よ
り、メラニン生成を抑制し、肌のしみやそばかす等の予
防や治療する目的や、コラーゲン代謝を促進し、こじわ
を予防する目的で、また、肌に潤いを与える目的でL−
アスコルビン酸が配合されている。2. Description of the Related Art Conventionally, for the purpose of suppressing melanin production, preventing and treating skin spots and freckles, and promoting collagen metabolism and preventing wrinkles, , L- for moisturizing skin
Contains ascorbic acid.
【0003】L−アスコルビン酸は、化粧料に配合した
場合、保存安定性が不十分である。このため、L−アス
コルビン酸を化学修飾した各種誘導体が開発されてい
る。[0003] L-ascorbic acid has insufficient storage stability when incorporated into cosmetics. For this reason, various derivatives obtained by chemically modifying L-ascorbic acid have been developed.
【0004】L−アスコルビン酸−2−リン酸ナトリウ
ム、L−アスコルビン酸−2−リン酸マグネシウムなど
のL−アスコルビン酸−2−リン酸塩は、L−アスコル
ビン酸を安定化する目的で開発された誘導体である。し
かし、これを配合した化粧料においても、長期保存で黄
変、変臭が生じるなど安定性が十分でなく、また、これ
に伴って有用性も低下するなどの問題点があった。L-ascorbic acid-2-phosphate such as sodium L-ascorbic acid-2-phosphate and magnesium L-ascorbic acid-2-phosphate has been developed for the purpose of stabilizing L-ascorbic acid. Derivatives. However, the cosmetics containing the same have problems such as insufficient stability such as yellowing and unpleasant odor when stored for a long period of time, and the usefulness thereof is also reduced.
【0005】そこで本発明者らは鋭意研究した結果、下
記の皮膚化粧料が、L−アスコルビン酸−2−リン酸塩
の黄変、変臭等を抑制し保存安定性に優れ、その結果、
美白効果、こじわを予防する、肌に潤いを与えるなどの
美肌効果に優れていることを見出し、本発明を完成する
に至った。[0005] The inventors of the present invention have conducted intensive studies and have found that the following skin cosmetics suppress the yellowing and unpleasant odor of L-ascorbic acid-2-phosphate and have excellent storage stability.
The inventors have found that they have excellent skin-whitening effects, such as whitening effect, prevention of wrinkles, and moisturizing the skin, and have completed the present invention.
【0006】本発明の目的は、保存安定性に優れ、色黒
の皮膚を速やかに淡色化する、こじわを予防する、肌に
潤いを与えるなどの効果に優れた皮膚化粧料を提供する
ことにある。An object of the present invention is to provide a skin cosmetic composition which is excellent in storage stability, is effective in quickly lightening dark-skinned skin, preventing wrinkles, and moisturizing the skin. It is in.
【0007】[0007]
【課題を解決するための手段】上記目的を達成する本発
明は、L−アスコルビン酸−2−リン酸塩と、ヒドロキ
シエタンジホスホン酸塩及びジエチレントリアミン五酢
酸塩の中から選ばれる少なくとも一種を含有する皮膚化
粧料(但し、ジブチルヒドロキシトルエン、並びに下記
一般式(I)で表されるアミノ酸誘導体又はその塩を含
有しない。) Ar−X−C(R)H−(CH 2) n−Y (I) [式中、Arは2−ヒドロキシフェニル基、2−ヒドロ
キシ−1−ナフチル基またはピリジル基を表し、そして
これらの基の芳香環に結合した水素原子は、1個または
複数個が独立にハロゲン原子、炭素原子数1〜6のアル
キル基、ヒドロキシル基、炭素原子数1〜6のヒドロキ
シアルキル基、ニトロ基、炭素原子数1〜6のアルコキ
シル基またはカルボキシル基で置換されていてもよく、
Rはアミノ酸の側鎖を表し、Xは−CH 2−NH−また
は−CH=N−を表し、Yは水素原子、−COOR 1、
−SO 3H、−CON(R 2)R 3、−CONHCH
(R 5)COOR 4または−CH 2OHを表し(基中、
R 1〜R 4は水素原子または炭素原子数1〜6のアルキ
ル基を表し、R 5はアミノ酸の側鎖を表す。)、そして
nは0または1の整数を表す。]
である。The present invention for achieving the above object contains L-ascorbic acid-2-phosphate and at least one selected from hydroxyethanediphosphonate and diethylenetriaminepentaacetate. Skin cosmetics (but dibutylhydroxytoluene, and
Including the amino acid derivative represented by the general formula (I) or a salt thereof.
Do not have. ) Ar—X—C (R) H— (CH 2 ) n —Y (I) wherein Ar is a 2-hydroxyphenyl group, 2-hydro
Represents an xy-1-naphthyl group or a pyridyl group, and
One or more hydrogen atoms are bonded to the aromatic ring of these groups.
A plurality of independently halogen atoms, alkyl having 1 to 6 carbon atoms
Kill group, hydroxyl group, hydroxy having 1 to 6 carbon atoms
Silalkyl group, nitro group, alkoxy having 1 to 6 carbon atoms
May be substituted with a sil group or a carboxyl group,
R represents a side chain of an amino acid, X is -CH 2 -NH- also
Represents —CH = N—, Y represents a hydrogen atom, —COOR 1 ,
-SO 3 H, -CON (R 2 ) R 3, -CONHCH
(R 5 ) represents COOR 4 or —CH 2 OH (in the group,
R 1 to R 4 are a hydrogen atom or an alkyl having 1 to 6 carbon atoms.
R 5 represents a side chain of an amino acid. ), And
n represents an integer of 0 or 1. ] .
【0008】[0008]
【発明の実施の形態】以下、本発明の実施の形態を詳述
する。Embodiments of the present invention will be described below in detail.
【0009】本発明に用いられるL−アスコルビン酸−
2−リン酸塩は、例えばL−アスコルビン酸−2−リン
酸ナトリウム、L−アスコルビン酸−2−リン酸マグネ
シウム、L−アスコルビン酸−2−リン酸カリウム、L
−アスコルビン酸−2−リン酸カルシウム、L−アスコ
ルビン酸−2−リン酸アンモニウム等が挙げられるが、
これらに限定されるものではない。L-ascorbic acid used in the present invention
2-phosphate is, for example, sodium L-ascorbic acid-2-phosphate, magnesium L-ascorbic acid-2-phosphate, potassium L-ascorbic acid-2-phosphate,
-Ascorbic acid-2-calcium phosphate, L-ascorbic acid-2-ammonium phosphate and the like,
It is not limited to these.
【0010】その含有量は、化粧料の処方成分全量を基
準として、0.001〜30重量%が好ましく、更に好
ましくは0.01〜10重量%の範囲内である。0.0
01重量%未満では美白、美肌効果が得られにくく、3
0重量%を超えると沈殿や結晶が生じやすくなるため、
好ましくないことがある。The content is preferably 0.001 to 30% by weight, more preferably 0.01 to 10% by weight, based on the total amount of the cosmetic ingredients. 0.0
If it is less than 01% by weight, it is difficult to obtain a whitening effect and a beautiful skin effect.
If the content exceeds 0% by weight, precipitation and crystals tend to occur.
May not be preferred.
【0011】本発明に用いられるヒドロキシエタンジホ
スホン酸塩としては、ヒドロキシエタンジホスホン酸四
ナトリウム、ヒドロキシエタンジホスホン酸三ナトリウ
ム、ヒドロキシエタンジホスホン酸二ナトリウム、ヒド
ロキシエタンジホスホン酸ナトリウム、ヒドロキシエタ
ンジホスホン酸四カリウム、ヒドロキシエタンジホスホ
ン酸三カリウム、ヒドロキシエタンジホスホン酸二カリ
ウム、ヒドロキシエタンジホスホン酸カリウムなどが挙
げられるが、これらに限定されない。The hydroxyethanediphosphonate used in the present invention includes tetrasodium hydroxyethanediphosphonate, trisodium hydroxyethanediphosphonate, disodium hydroxyethanediphosphonate, sodium hydroxyethanediphosphonate, and hydroxyethane. Examples include, but are not limited to, tetrapotassium diphosphonate, tripotassium hydroxyethanediphosphonate, dipotassium hydroxyethanediphosphonate, potassium hydroxyethanediphosphonate, and the like.
【0012】本発明に用いられるジエチレントリアミン
五酢酸塩としては、ジエチレントリアミン五酢酸五ナト
リウム、ジエチレントリアミン五酢酸四ナトリウム、ジ
エチレントリアミン五酢酸三ナトリウム、ジエチレント
リアミン五酢酸二ナトリウム、ジエチレントリアミン五
酢酸ナトリウム、ジエチレントリアミン五酢酸五カリウ
ム、ジエチレントリアミン五酢酸四カリウム、ジエチレ
ントリアミン五酢酸三カリウム、ジエチレントリアミン
五酢酸二カリウム、ジエチレントリアミン五酢酸カリウ
ムなどが挙げられるが、これらに限定されるものではな
い。The diethylene triamine pentaacetate used in the present invention includes pentasodium diethylene triamine pentaacetate, tetrasodium diethylene triamine pentaacetate, trisodium diethylene triamine pentaacetate, disodium diethylene triamine pentaacetate, sodium diethylene triamine pentaacetate, pentapotassium diethylene triamine pentaacetate, Examples include, but are not limited to, tetrapotassium diethylenetriaminepentaacetate, tripotassium diethylenetriaminepentaacetate, dipotassium diethylenetriaminepentaacetate, potassium diethylenetriaminepentaacetate, and the like.
【0013】ヒドロキシエタンジホスホン酸塩及びジエ
チレントリアミン五酢酸塩の中から選ばれる少なくとも
一種の配合量は化粧料全量中、0.001〜30重量%
が好ましく、更に好ましくは0.01〜10重量%であ
る。0.001重量%未満では十分な効果が得られず、
30重量%を超えると沈殿や結晶が生じやすくなるため
好ましくないことがある。The amount of at least one compound selected from the group consisting of hydroxyethane diphosphonate and diethylene triamine pentaacetate is 0.001 to 30% by weight based on the total amount of the cosmetic.
And more preferably 0.01 to 10% by weight. If the content is less than 0.001% by weight, a sufficient effect cannot be obtained.
If it exceeds 30% by weight, precipitation and crystals tend to occur, which is not preferable.
【0014】L−アスコルビン酸−2−リン酸ナトリウ
ムと、ヒドロキシエタンジホスホン酸塩及びジエチレン
トリアミン五酢酸塩から選択される成分の和との配合比
率は、重量で100:1〜1:50が好ましく、更に好
ましくは30:1〜1:10である。The blending ratio of sodium L-ascorbic acid-2-phosphate to the sum of components selected from hydroxyethanediphosphonate and diethylenetriaminepentaacetate is preferably 100: 1 to 1:50 by weight. , More preferably 30: 1 to 1:10.
【0015】本発明の化粧料には上記原料の他に、色
素、香料、防腐剤、界面活性剤、顔料、抗酸化剤、保湿
剤、紫外線吸収剤などを、本発明の目的を達成する範囲
内で適宜配合することができる。In the cosmetic of the present invention, in addition to the above-mentioned raw materials, pigments, fragrances, preservatives, surfactants, pigments, antioxidants, humectants, ultraviolet absorbers, etc. are included in the range for achieving the object of the present invention. Can be appropriately blended.
【0016】本発明の化粧料の剤型としては、クリー
ム、乳液、化粧水、パックなどが挙げられる。この化粧
料は、例えば乳液等の場合、油相及び水相をそれぞれ加
熱溶解したものを乳化分散して冷却する通常の方法によ
り製造することができる。The cosmetic preparation of the present invention includes creams, emulsions, lotions, packs and the like. For example, in the case of an emulsion or the like, this cosmetic can be manufactured by a usual method of emulsifying and dispersing an oil phase and an aqueous phase which are each dissolved by heating and cooling.
【0017】[0017]
【実施例】以下、実施例及び比較例に基づいて本発明を
詳述する。実施例に記載の保存安定性試験法、皮膚色明
度回復試験法、実用テストは下記のとおりである。The present invention will be described below in detail based on examples and comparative examples. The storage stability test method, skin color lightness recovery test method and practical test described in the examples are as follows.
【0018】なお、実施例等で用いられる本発明に係わ
る化合物の略号をそれぞれ次の括弧に示す。L−アスコ
ルビン酸−2−リン酸ナトリウム(APS)、L−アス
コルビン酸−2−リン酸マグネシウム(APM)、L−
アスコルビン酸−2−リン酸カリウム(APK)、ヒド
ロキシエタンジホスホン酸四ナトリウム(HEP4N
a)、ヒドロキシエタンジホスホン酸三ナトリウム(H
EP3Na)、ヒドロキシエタンジホスホン酸ナトリウ
ム(HEPNa)、ヒドロキシエタンジホスホン酸二カ
リウム(HEP2K)、ジエチレントリアミン五酢酸五
ナトリウム(DETA5Na)、ジエチレントリアミン
五酢酸四カリウム(DETA4K)、ジエチレントリア
ミン五酢酸三カリウム(DETA3K)、ジエチレント
リアミン五酢酸二カリウム(DETA2K)、ジエチレ
ントリアミン五酢酸カリウム(DETAK)The abbreviations of the compounds according to the present invention used in the examples and the like are shown in the following parentheses. L-ascorbic acid-2-sodium phosphate (APS), L-ascorbic acid-2-magnesium phosphate (APM), L-
Potassium ascorbic acid-2-phosphate (APK), tetrasodium hydroxyethanediphosphonate (HEP4N
a), trisodium hydroxyethanediphosphonate (H
EP3Na), sodium hydroxyethanediphosphonate (HEPNa), dipotassium hydroxyethanediphosphonate (HEP2K), pentasodium diethylenetriaminepentaacetate (DETA5Na), tetrapotassium diethylenetriaminepentaacetate (DETA4K), tripotassium diethylenetriaminepentaacetate (DETA3K) , Dipotassium diethylenetriaminepentaacetate (DETA2K), potassium diethylenetriaminepentaacetate (DETAK)
【0019】(1)保存安定性試験
同一試料を温度5℃、45℃の恒温槽に3か月間保存し
た後、両者の経日における外観(色)、においの変化を
比較した。判定結果は5℃保存品と比較したときの45
℃保存品の色、においの差異を下記の判定基準により
◎、○、△、×で示した。(1) Storage stability test After the same sample was stored in a thermostat at a temperature of 5 ° C. and 45 ° C. for 3 months, changes in appearance (color) and smell of the two over time were compared. The judgment result was 45 when compared with the product stored at 5 ° C.
Differences in color and odor of the products stored at ℃ were indicated by ◎, ○, Δ and × according to the following criteria.
【0020】 [0020]
【0021】 [0021]
【0022】(2)皮膚色明度回復試験法
被験者20名の背部皮膚にUV−B領域の紫外線を最小
紅斑量の2倍照射し、試料塗布部位と非塗布部位を設定
して各々の皮膚の基準明度(V0 値,V0 ´値)を測定
した。引き続いて塗布部位には試料を1日2回ずつ15
週間連続塗布した後、3,6,9,12,15週間後の
塗布部位及び非塗布部位の皮膚の明度(Vn 値,Vn ´
値)を測定し、下記の判定基準にしたがって皮膚色の回
復を評価した。尚、皮膚の明度(マンセル表色系V値)
は高速分光色彩計で測定して得られたX,Y,Z値より
算出した。また評価は被験者20名ついて、6週間後の
評価点の平均値で示した。(2) Skin Color Brightness Recovery Test Method The UV light in the UV-B region was irradiated to the back skin of 20 subjects twice as much as the minimum erythema amount, and the sample application site and the non-application site were set, and each skin was examined. The reference lightness (V0 value, V0 'value) was measured. Subsequently, the sample was applied to the application site twice a day for 15 times.
After continuous application for 3 weeks, the lightness (Vn value, Vn ') of the skin at the application site and the non-application site after 3, 6, 9, 12, and 15 weeks
Was measured, and the recovery of skin color was evaluated according to the following criteria. The lightness of the skin (Munsell color system V value)
Was calculated from the X, Y, and Z values obtained by measuring with a high-speed spectral colorimeter. The evaluation was shown as an average value of the evaluation points after 6 weeks for 20 subjects.
【0023】 [0023]
【0024】(3)実用テスト(こじわ改善、保湿性)
被験者25名に試料を顔面に連用させ、こじわ改善効
果、保湿効果について、連用1か月後の状態を連用前と
比較して評価した。評価は「こじわが改善された」「肌
に潤いがでた」と回答した人の人数で結果を示した。(3) Practical test (improvement of wrinkle, moisturizing property) A sample was continuously applied to the face of 25 subjects, and the effect of improving wrinkle and moisturizing effect was compared one month after continuous use with that before continuous use. evaluated. The evaluation was based on the number of persons who answered that "the wrinkles were improved" and "the skin was moistened".
【0025】実施例1〜6,比較例1〜3
L−アスコルビン酸−2−リン酸塩と、ヒドロキシエタ
ンジホスホン酸塩及びジエチレントリアミン五酢酸塩の
中から選ばれる少なくとも一種を表1の組成において配
合し、下記の調製方法に基づいてスキンクリームを調製
した。各々について前記の試験を実施し、その結果を表
2及び表3に示した。組成Examples 1 to 6, Comparative Examples 1 to 3 L-ascorbic acid-2-phosphate and at least one selected from hydroxyethanediphosphonate and diethylenetriaminepentaacetate in the composition shown in Table 1 And a skin cream was prepared based on the following preparation method. The above-mentioned test was performed for each, and the results are shown in Tables 2 and 3. composition
【0026】[0026]
【表1】 [Table 1]
【0027】[0027]
【表2】 [Table 2]
【0028】[0028]
【表3】 [Table 3]
【0029】調製方法
(A)を70℃、Bを50℃にて均一に溶解し、(A)
を攪拌しながら(B)を(A)に注入して乳化分散した
後、攪拌しながら温度30℃まで冷却して調製する。Preparation method (A) is uniformly dissolved at 70 ° C. and B at 50 ° C.
Is stirred, and (B) is poured into (A) to emulsify and disperse, and then cooled to a temperature of 30 ° C. while stirring to prepare.
【0030】特性
本発明の実施例1〜6のスキンクリームは、保存安定性
に優れ、各種有用性にも優れていた。一方、比較例1〜
3のスキンクリームは、保存安定性が悪く、また十分な
効果が認められず、本発明の実施例に比べて劣ってい
た。Characteristics The skin creams of Examples 1 to 6 of the present invention were excellent in storage stability and various usefulness. On the other hand, Comparative Examples 1 to
The skin cream No. 3 had poor storage stability and did not show a sufficient effect, and was inferior to the examples of the present invention.
【0031】実施例7 [スキンローション]
表4の組成により本発明のスキンローションを下記の製
法によって調製した。
組成Example 7 [Skin lotion] The skin lotion of the present invention having the composition shown in Table 4 was prepared by the following method. composition
【0032】[0032]
【表4】 [Table 4]
【0033】調製法
(A),(B)の各成分をそれぞれ混合溶解し、(B)
を(A)に加えて混合攪拌して調製した。Each of the components of the preparation methods (A) and (B) is mixed and dissolved,
Was added to (A) and mixed and stirred.
【0034】特性
この実施例7のスキンローションは、保存安定性に優
れ、各種有用性試験において良好な結果を示した。Properties The skin lotion of Example 7 was excellent in storage stability and showed good results in various usefulness tests.
【0035】実施例8 [デイエッセンス]
表5の組成により本発明のデイエッセンス(日中用美容
液)を下記の製法によって調製した。
組成Example 8 [Day Essence] The day essence (daytime serum) of the present invention was prepared according to the composition shown in Table 5 by the following method. composition
【0036】[0036]
【表5】 * ,**:ジボダン社製[Table 5] *, **: Made by Givaudan
【0037】調製法
(A)を70℃,(B)を50℃にて各成分をそれぞれ
混合溶解し、(B)を(A)に加えて混合攪拌し、30
℃まで冷却して調製した。Preparation Method (A) was mixed and dissolved at 70 ° C. and (B) at 50 ° C., and each component was mixed and dissolved. (B) was added to (A) and mixed and stirred.
Prepared by cooling to ° C.
【0038】特性
この実施例8のデイエッセンスは、保存安定性に優れ、
各種有用性試験において良好な結果を示した。Characteristics The deessence of Example 8 has excellent storage stability.
Good results were shown in various usefulness tests.
【0039】[0039]
【発明の効果】以上記載のごとく、本発明が、保存安定
性に優れ、色黒の皮膚を速やかに淡色化する、こじわを
予防する、肌に潤いを与えるなどの効果に優れた皮膚化
粧料を提供することは明らかである。Industrial Applicability As described above, the present invention provides skin cosmetics having excellent storage stability, excellent effects such as quick lightening of dark-skinned skin, prevention of wrinkles, and moisturizing the skin. It is clear that the fee is provided.
───────────────────────────────────────────────────── フロントページの続き (58)調査した分野(Int.Cl.7,DB名) A61K 7/48 A61K 7/00 ──────────────────────────────────────────────────続 き Continued on the front page (58) Field surveyed (Int.Cl. 7 , DB name) A61K 7/48 A61K 7/00
Claims (1)
ヒドロキシエタンジホスホン酸塩及びジエチレントリア
ミン五酢酸塩の中から選ばれる少なくとも一種を含有す
る皮膚化粧料。(但し、ジブチルヒドロキシトルエン、
並びに下記一般式(I)で表されるアミノ酸誘導体又は
その塩を含有しない。) Ar−X−C(R)H−(CH 2) n−Y (I) [式中、Arは2−ヒドロキシフェニル基、2−ヒドロ
キシ−1−ナフチル基またはピリジル基を表し、そして
これらの基の芳香環に結合した水素原子は、1個または
複数個が独立にハロゲン原子、炭素原子数1〜6のアル
キル基、ヒドロキシル基、炭素原子数1〜6のヒドロキ
シアルキル基、ニトロ基、炭素原子数1〜6のアルコキ
シル基またはカルボキシル基で置換されていてもよく、
Rはアミノ酸の側鎖を表し、Xは−CH 2−NH−また
は−CH=N−を表し、Yは水素原子、−COOR 1、
−SO 3H、−CON(R 2)R 3、−CONHCH
(R 5)COOR 4または−CH 2OHを表し(基中、
R 1〜R 4は水素原子または炭素原子数1〜6のアルキ
ル基を表し、R 5はアミノ酸の側鎖を表す。)、そして
nは0または1の整数を表す。] 1. An L-ascorbic acid-2-phosphate salt,
Skin cosmetics containing at least one selected from hydroxyethane diphosphonate and diethylene triamine pentaacetate. (However, dibutylhydroxytoluene,
And an amino acid derivative represented by the following general formula (I) or
Contains no salts. ) Ar—X—C (R) H— (CH 2 ) n —Y (I) wherein Ar is a 2-hydroxyphenyl group, 2-hydro
Represents an xy-1-naphthyl group or a pyridyl group, and
One or more hydrogen atoms are bonded to the aromatic ring of these groups.
A plurality of independently halogen atoms, alkyl having 1 to 6 carbon atoms
Kill group, hydroxyl group, hydroxy having 1 to 6 carbon atoms
Silalkyl group, nitro group, alkoxy having 1 to 6 carbon atoms
May be substituted with a sil group or a carboxyl group,
R represents a side chain of an amino acid, X is -CH 2 -NH- also
Represents —CH = N—, Y represents a hydrogen atom, —COOR 1 ,
-SO 3 H, -CON (R 2 ) R 3, -CONHCH
(R 5 ) represents COOR 4 or —CH 2 OH (in the group,
R 1 to R 4 are a hydrogen atom or an alkyl having 1 to 6 carbon atoms.
R 5 represents a side chain of an amino acid. ), And
n represents an integer of 0 or 1. ]
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP32108396A JP3517068B2 (en) | 1996-11-15 | 1996-11-15 | Skin cosmetics |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP32108396A JP3517068B2 (en) | 1996-11-15 | 1996-11-15 | Skin cosmetics |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH10147512A JPH10147512A (en) | 1998-06-02 |
JP3517068B2 true JP3517068B2 (en) | 2004-04-05 |
Family
ID=18128629
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP32108396A Expired - Lifetime JP3517068B2 (en) | 1996-11-15 | 1996-11-15 | Skin cosmetics |
Country Status (1)
Country | Link |
---|---|
JP (1) | JP3517068B2 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10036655A1 (en) * | 2000-07-26 | 2002-02-07 | Basf Ag | Cosmetic or dermatological preparations to prevent skin damage from peroxides |
JP5955625B2 (en) * | 2012-04-27 | 2016-07-20 | 御木本製薬株式会社 | Skin preparation |
CA3047424A1 (en) | 2016-12-22 | 2018-06-28 | Unilever Plc | Stabilization of cosmetic compositions comprising fish oils and hydroxylated fatty acids and/or its derivatives |
-
1996
- 1996-11-15 JP JP32108396A patent/JP3517068B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JPH10147512A (en) | 1998-06-02 |
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