JP2000290131A - Bleaching preparation - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain the subject bleaching preparation exhibiting an inhibitory effect on melanization, etc., developing a bleaching effect in a short time by including one or more kinds selected from extracts of Glycyrrhiza glaba Linne Var, Silybum marianum Gaertn., Prunus persica Batsch and an extract of wheat embryo bud. SOLUTION: This bleaching preparation contains (A) one or more kinds selected from extracts of (i) Glycyrrhiza glaba Linne Var., (ii) Silybum marianum Gaertn. and (iii) Prunus persica Batsch and (B) an extract of wheat embryo bud. Preferably the preparation contains 0.0001-10 wt.% calculated as a dried solid content of the compound A and 0.0001-10 wt.% content of the component B. For example, oil-soluble Glycyrrhiza glaba Linne Var. essence PT (40) (trade name) and glabridin extract from Glycyrrhiza glaba Linne Var., can be used as the component (i), an extract obtained from the fruit or the whole plant of Silybum marianum Gaertn. with acetone as the component (ii) and an extract obtained from leaves, fruits, seeds, etc., of Prunus persica Batsch with ethanol as the component (iii). A substance obtained by extracting wheat embryo bud with water, concentrating and filtering can be used as the composition B.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to cosmetics and quasi-drugs.

[0002]

2. Description of the Related Art Conventionally, whitening cosmetics for the purpose of preventing and treating skin spots and freckles include L-ascorbic acid and its derivatives, hydroquinone derivatives, pyrones of kojic acid, and placenta of placenta extract. Extracts and the like are blended.

[0003] These substances have effects such as suppression of melanin production and light-color bleaching action of the produced melanin, and are widely known as substances having a whitening effect. However, when these substances are used alone, for example, L-ascorbic acid and its derivatives have insufficient storage stability and their effects are not sufficiently exerted, and hydroquinone derivatives have insufficient safety, for example, they have a problem in safety. It was not something.

[0004]

SUMMARY OF THE INVENTION The present inventors have conducted intensive studies to solve the above-mentioned drawbacks. As a result, the whitening cosmetics described below prevent inflammation caused by ultraviolet rays, suppress melanin production due to ultraviolet damage, and The present invention has been found not only to exhibit an excellent melanin production inhibitory effect, but also to promote excretion of melanin pigments by conditioning the skin and to exhibit an excellent whitening effect in a short period of time.

[0005] That is, an object of the present invention is not only to prevent inflammation due to ultraviolet rays, to suppress melanin production due to ultraviolet damage and to show an excellent inhibitory effect on melanin production, but also to promote excretion of melanin pigments by adjusting skin,
An object of the present invention is to provide a whitening cosmetic which expresses an excellent whitening effect in a short period of time.

[0006]

According to the present invention, which achieves the above objects, there is provided licorice (Glycyrrhiza glabaL).
inne Var. ), Maria Thistle (Silybum)
marianum Gaertn. ), Peach (Prun
us persica Batsch) and a whitening cosmetic containing an extract of wheat germ.

[0007]

BEST MODE FOR CARRYING OUT THE INVENTION An embodiment of the present invention is a whitening cosmetic. Hereinafter, the configuration of the present invention will be described in detail.

[0008] The wheat germ extract used in the present invention comprises:
For example, it can be obtained by extracting with water, concentrating this, and then filtering. However, it is not limited to this manufacturing method.

The amount of the wheat germ extract in the whitening cosmetic composition of the present invention is 0.000 in terms of the dry solid content of the extract.
The content is preferably, but not limited to, 1 to 10.0% by weight.

The extract of licorice and Maria thistle used in the present invention may be water or a lower alcohol such as methanol, ethanol, propanol or 1,3 butylene glycol, benzene, ethyl ether, chloroform, ethyl acetate, butyl acetate, acetone or It is extracted by their mixture. The extract may be directly incorporated into cosmetics, but it is preferable to use the extract in the form of a powder by freeze-drying or spray-drying. It is also possible to purify the extract by means of liquid-liquid distribution, adsorption chromatography or the like, and to mix it in a liquid form or a powdered form.

As the licorice extract used in the present invention, for example, an oil-soluble licorice extract PT (40) (manufactured by Maruzen Pharmaceutical Co., Ltd.) is commercially available. In addition, licorice (Glycyrrhiza)
Glaba Linne Var. ) Can also be used.

[0012] The extract of Maria Thistle used in the present invention includes Maria Thistle (Silybum maria).
num Gaertn. ) And those extracted from whole plants with acetone.

The peach (Prunus) used in the present invention
persica Batsch) extracts include leaves,
Actually, there may be mentioned those extracted from seeds and the like with ethanol.

The amount of the extract of licorice, peach and mari thistle in the whitening cosmetic composition of the present invention is preferably 0.0001 to 10% by weight in terms of the dry solid content of the extract, but is not limited thereto.

In the cosmetic of the present invention, in addition to the above-mentioned raw materials, generally known raw materials such as dyes, fragrances, preservatives, surfactants, pigments, antioxidants, humectants, and ultraviolet absorbers are used. It can be appropriately compounded within a range that achieves the object of the present invention.

The cosmetic of the present invention may be in the form of a cream,
Any dosage form commonly used in cosmetics such as emulsions, lotions, and packs may be used.

The cosmetic of the present invention may be used, for example, in the case of a lotion.
It can be manufactured by an ordinary method such as mixing and dissolving each component.

[0018]

The present invention will be described below in detail based on examples and comparative examples. In addition, the compounding% shown in the examples is% by weight. The skin color lightness recovery test method and sensory test (whitening effect) described in the examples are as follows. The methods for preparing the extract obtained from wheat germ and other plant extracts of the present invention used in the following Examples are as follows, but the scope of the present invention is not limited to these.

(Preparation method of extract obtained from wheat germ)
50 g of wheat germ is immersed in 1 L of water, and left stirring for 24 hours a day. The obtained liquid was concentrated and then filtered. Thereby, 15.7 g of wheat germ extract (solids conversion: 0.16
g) was obtained.

(Method for Preparing Licorice Extract) 5.00 g of licorice root
To the mixture was added 500 ml of ethanol, and the mixture was extracted under reflux for 3 hours. Thereafter, the mixture was filtered, and the obtained extract was applied to a column (Φ3) of Diaion HP-20 (manufactured by Mitsubishi Kasei Kogyo Co., Ltd.).
cm × 11cm, Vt = 80ml), then 800m
Washed with 1 l of a 10% aqueous ethanol solution. Then, 40
The eluate was eluted with 0 ml of 70% aqueous ethanol, and the eluate was concentrated under reduced pressure and freeze-dried to obtain 0.04 g of glabridine.

(Preparation Method of Maria Thistle Extract) 500 ml of acetone was added to 5.00 g of thistle seeds, and the mixture was extracted under reflux for 3 hours. Thereafter, the mixture is filtered, and the obtained extract is subjected to Diaion HP-20 (manufactured by Mitsubishi Chemical Industry Co., Ltd.)
Was loaded onto a column (Φ3 cm × 11 cm, Vt = 80 ml), and washed with 500 ml of purified water. Then, 500
The elute was eluted with 40 ml of a 40% aqueous ethanol solution, and the eluate was concentrated under reduced pressure and freeze-dried to obtain 2.68 g of a dry powder.

(Preparation method of peach extract) Peach seeds (peach kernel) 1
500 ml of ethanol was added to 0.0 g, and extraction was performed for 3 hours under reflux. Thereafter, the mixture was filtered, and the obtained extract was loaded on a column (Φ3 cm × 11 cm, Vt = 80 ml) of Diaion HP-20 (manufactured by Mitsubishi Kasei Kogyo Co., Ltd.).
It was washed with 800 ml of a 10% aqueous ethanol solution. The eluate was then eluted with 400 ml of 70% aqueous ethanol, and the eluate was concentrated under reduced pressure and lyophilized to give a dry powder of 1.04%.
g was obtained.

(1) Skin Color Brightness Recovery Test Method The ultraviolet light in the UV-B region was irradiated twice as much as the minimum erythema dose to the back skin of 20 subjects, and the sample application site and non-application site were set, and each skin was examined. The reference lightness (V0 value, V0 'value) was measured. Then, apply the sample twice a day to the application site.
After continuous application for 5 weeks, the lightness (Vn value, Vn) of the skin at the application site and the non-application site after 3, 6, 9, 12, and 15 weeks
n ′ value), and the recovery of skin color was evaluated according to the following criteria. The lightness of the skin (Munsell color system V
Value) was calculated from the X, Y, and Z values obtained by measuring with a high-speed spectral colorimeter. In addition, the evaluation was shown as an average value of the evaluation points after 3 weeks for 20 subjects.

[0024]

[Table 1]

(2) Sensory test Twenty test subjects continuously used the sample for 10 days, and then evaluated the characteristics of the sample. The evaluation was shown by the number of respondents who answered that "the whitening effect was felt" to the questionnaire item of the whitening effect.

Examples 1 to 3 and Comparative Examples 1 to 5 Extracts obtained from wheat germ, licorice and Maria Thistle extracts were each blended in the composition shown in Table 2, and a skin cream was prepared according to the following preparation method. did. The above test was performed for each, and the results are shown in Table 3.

[0027]

[Table 2]

[0028]

[Table 3]

Preparation method: (A) and (B) are uniformly dissolved at 70 ° C., (B) is poured into (A) while stirring (A), emulsified and dispersed, and then stirred to a temperature of 30 ° C. Prepared by cooling to ° C.

From the results shown in Table 3, it can be seen that the skin creams of Examples 1 to 3 of the present invention show good characteristics in the above-mentioned tests. On the other hand, the skin creams of Comparative Examples 1 to 5 did not show a sufficient effect, indicating that they were inferior to the examples of the present invention.

Example 4 (Skin Lotion) The skin lotion of the present invention was prepared according to the composition shown in Table 4 by a conventional method.

[0032]

[Table 4]

The skin lotion of Example 4 showed good results in the above tests.

Example 5 (Day Essence) The day essence (daytime serum) of the present invention was prepared according to the composition shown in Table 5 by the following method.

[0035]

[Table 5]

Preparation method: (A) and (B) were mixed and dissolved at 70 ° C. for each component, and (B) was added to (A), mixed, stirred and cooled to 30 ° C.

The day essence of Example 4 showed good results in the above tests.

[0038]

As described above, it is apparent that the present invention provides an excellent whitening cosmetic which exhibits a whitening effect in a short period of time.

 ────────────────────────────────────────────────── ─── Continuing on the front page (72) Inventor Toshio Horikoshi 5-28, Kotobukicho, Odawara-shi, Kanagawa Kanebo Co., Ltd. Basic Research Laboratory F-term (reference) 4C083 AA082 AA111 AA112 AB242 AC012 AC022 AC102 AC122 AC212 AC242 AC422 AC442 AC482 AC662 AD352 AD572 CC01 CC04 CC05 DD23 DD31 EE16 FF01 FF05

Claims (1)

[Claims] [Claim 1] Glycyrrhiza glab
a Linne Var. ), Maria Thistle (Silyb
um marianum Gaertn. ), Peach (Pr
A whitening cosmetic comprising: an extract of unus persica Batsch) and an extract of wheat germ.