CN110638696A - Composition for repairing skin barrier and preparation method and application thereof - Google Patents
Composition for repairing skin barrier and preparation method and application thereof Download PDFInfo
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- CN110638696A CN110638696A CN201911022080.XA CN201911022080A CN110638696A CN 110638696 A CN110638696 A CN 110638696A CN 201911022080 A CN201911022080 A CN 201911022080A CN 110638696 A CN110638696 A CN 110638696A
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- Prior art keywords
- ceramide
- composition
- skin
- calcium
- preparation
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- 239000000203 mixture Substances 0.000 title claims abstract description 79
- 238000002360 preparation method Methods 0.000 title claims abstract description 21
- 230000008591 skin barrier function Effects 0.000 title abstract description 27
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims abstract description 34
- 229910001424 calcium ion Inorganic materials 0.000 claims abstract description 32
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 claims abstract description 28
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 claims abstract description 28
- 229940106189 ceramide Drugs 0.000 claims abstract description 28
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 claims abstract description 28
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 claims abstract description 28
- -1 calcium ion compound Chemical class 0.000 claims abstract description 21
- 235000012000 cholesterol Nutrition 0.000 claims abstract description 17
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical class CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims abstract description 16
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims abstract description 16
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 claims abstract description 16
- 229960003237 betaine Drugs 0.000 claims abstract description 16
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 48
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 48
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 30
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims description 16
- 150000005846 sugar alcohols Polymers 0.000 claims description 15
- LEACJMVNYZDSKR-UHFFFAOYSA-N 2-octyldodecan-1-ol Chemical compound CCCCCCCCCCC(CO)CCCCCCCC LEACJMVNYZDSKR-UHFFFAOYSA-N 0.000 claims description 14
- BTFJIXJJCSYFAL-UHFFFAOYSA-N arachidyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCO BTFJIXJJCSYFAL-UHFFFAOYSA-N 0.000 claims description 14
- 239000002537 cosmetic Substances 0.000 claims description 14
- 229920005862 polyol Polymers 0.000 claims description 11
- 150000003077 polyols Chemical class 0.000 claims description 11
- 238000002156 mixing Methods 0.000 claims description 8
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 7
- 239000001110 calcium chloride Substances 0.000 claims description 7
- 229910001628 calcium chloride Inorganic materials 0.000 claims description 7
- 238000003756 stirring Methods 0.000 claims description 6
- BBAFBDLICMHBNU-MFZOPHKMSA-N N-(2-hydroxyoctadecanoyl)-4-hydroxysphinganine Chemical compound CCCCCCCCCCCCCCCCC(O)C(=O)N[C@@H](CO)[C@H](O)[C@H](O)CCCCCCCCCCCCCC BBAFBDLICMHBNU-MFZOPHKMSA-N 0.000 claims description 5
- ATGQXSBKTQANOH-UWVGARPKSA-N N-oleoylphytosphingosine Chemical compound CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@H](CO)NC(=O)CCCCCCC\C=C/CCCCCCCC ATGQXSBKTQANOH-UWVGARPKSA-N 0.000 claims description 5
- MIUIRGGKIICMBP-NFOZDHADSA-N [27-oxo-27-[[(2s,3s,4r)-1,3,4-trihydroxyoctadecan-2-yl]amino]heptacosyl] octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCCCCCCCCCCCCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)[C@H](O)CCCCCCCCCCCCCC MIUIRGGKIICMBP-NFOZDHADSA-N 0.000 claims description 5
- 239000004227 calcium gluconate Substances 0.000 claims description 5
- 229960004494 calcium gluconate Drugs 0.000 claims description 5
- 235000013927 calcium gluconate Nutrition 0.000 claims description 5
- NEEHYRZPVYRGPP-UHFFFAOYSA-L calcium;2,3,4,5,6-pentahydroxyhexanoate Chemical compound [Ca+2].OCC(O)C(O)C(O)C(O)C([O-])=O.OCC(O)C(O)C(O)C(O)C([O-])=O NEEHYRZPVYRGPP-UHFFFAOYSA-L 0.000 claims description 5
- 229940048864 ceramide 1 Drugs 0.000 claims description 5
- 229940044176 ceramide 3 Drugs 0.000 claims description 5
- 230000003020 moisturizing effect Effects 0.000 claims description 5
- 229960005069 calcium Drugs 0.000 claims description 4
- 239000011575 calcium Substances 0.000 claims description 4
- 229910052791 calcium Inorganic materials 0.000 claims description 4
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 4
- 238000000265 homogenisation Methods 0.000 claims description 3
- 229940127557 pharmaceutical product Drugs 0.000 claims description 3
- GBGUSZWBYGKEBA-VBYMIUBRSA-N (2R)-2-hydroxy-N-[(E,2S,3R,6R)-1,3,6-trihydroxyoctadec-4-en-2-yl]tetracosanamide Chemical compound CCCCCCCCCCCCCCCCCCCCCC[C@@H](O)C(=O)N[C@@H](CO)[C@H](O)\C=C\[C@H](O)CCCCCCCCCCCC GBGUSZWBYGKEBA-VBYMIUBRSA-N 0.000 claims description 2
- QWGRWMMWNDWRQN-UHFFFAOYSA-N 2-methylpropane-1,3-diol Chemical compound OCC(C)CO QWGRWMMWNDWRQN-UHFFFAOYSA-N 0.000 claims description 2
- LXAHHHIGZXPRKQ-UHFFFAOYSA-N 5-fluoro-2-methylpyridine Chemical compound CC1=CC=C(F)C=N1 LXAHHHIGZXPRKQ-UHFFFAOYSA-N 0.000 claims description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 2
- OPSXJNAGCGVGOG-DKWTVANSSA-L Calcium L-aspartate Chemical compound [Ca+2].[O-]C(=O)[C@@H](N)CC([O-])=O OPSXJNAGCGVGOG-DKWTVANSSA-L 0.000 claims description 2
- WAYLDHLWVYQNSQ-KEFDUYNTSA-N N-2-hydroxylignoceroylsphingosine Chemical compound CCCCCCCCCCCCCCCCCCCCCCC(O)C(=O)N[C@@H](CO)[C@H](O)\C=C\CCCCCCCCCCCCC WAYLDHLWVYQNSQ-KEFDUYNTSA-N 0.000 claims description 2
- ZBQZXOVJGDSANU-SPUWTEBASA-N N-[(E,2S,3R,6R)-1,3,6-trihydroxyoctadec-4-en-2-yl]tetracosanamide Chemical compound CCCCCCCCCCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)\C=C\[C@H](O)CCCCCCCCCCCC ZBQZXOVJGDSANU-SPUWTEBASA-N 0.000 claims description 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims description 2
- GCDXVKZXCQGDHC-BLCQCPAESA-N [30-oxo-30-[[(2s,3s,4r)-1,3,4-trihydroxyoctadecan-2-yl]amino]triacontyl] (9z,12z)-octadeca-9,12-dienoate Chemical compound CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@H](CO)NC(=O)CCCCCCCCCCCCCCCCCCCCCCCCCCCCCOC(=O)CCCCCCC\C=C/C\C=C/CCCCC GCDXVKZXCQGDHC-BLCQCPAESA-N 0.000 claims description 2
- ZGBFGAHZKZQSLG-UMCOJZBLSA-N [30-oxo-30-[[(e,2s,3r,6r)-1,3,6-trihydroxyoctadec-4-en-2-yl]amino]triacontyl] (9z,12z)-octadeca-9,12-dienoate Chemical compound CCCCCCCCCCCC[C@@H](O)\C=C\[C@@H](O)[C@H](CO)NC(=O)CCCCCCCCCCCCCCCCCCCCCCCCCCCCCOC(=O)CCCCCCC\C=C/C\C=C/CCCCC ZGBFGAHZKZQSLG-UMCOJZBLSA-N 0.000 claims description 2
- 229940034055 calcium aspartate Drugs 0.000 claims description 2
- KEOZCAIGSRBLGC-UHFFFAOYSA-L calcium;2-oxopyrrolidine-1-carboxylate Chemical compound [Ca+2].[O-]C(=O)N1CCCC1=O.[O-]C(=O)N1CCCC1=O KEOZCAIGSRBLGC-UHFFFAOYSA-L 0.000 claims description 2
- 229940099417 ceramide 2 Drugs 0.000 claims description 2
- 229940095137 ceramide 6 ii Drugs 0.000 claims description 2
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 claims description 2
- 238000000855 fermentation Methods 0.000 claims description 2
- 230000004151 fermentation Effects 0.000 claims description 2
- ACCCMOQWYVYDOT-UHFFFAOYSA-N hexane-1,1-diol Chemical compound CCCCCC(O)O ACCCMOQWYVYDOT-UHFFFAOYSA-N 0.000 claims description 2
- 229940100573 methylpropanediol Drugs 0.000 claims description 2
- UWJJYHHHVWZFEP-UHFFFAOYSA-N pentane-1,1-diol Chemical compound CCCCC(O)O UWJJYHHHVWZFEP-UHFFFAOYSA-N 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims 1
- 210000003491 skin Anatomy 0.000 abstract description 32
- 150000002632 lipids Chemical class 0.000 abstract description 15
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- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000012360 testing method Methods 0.000 description 22
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 17
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- Emergency Medicine (AREA)
- Inorganic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
The invention relates to the technical field of biological medicines and personal care products, in particular to a composition for repairing a skin barrier and a preparation method and application thereof. The composition provided by the invention comprises a calcium ion compound, ceramide, cholesterol, hydrogenated lecithin and betaine. The skin repairing agent is used for repairing skin barriers, has a remarkable synergistic effect among components, can effectively supplement and promote the synthesis of lipid among skin cells, and can repair damaged skin and rebuild skin barriers. Meanwhile, the present invention provides an efficient preparation method of the above skin barrier repair composition. The composition has obvious relieving and treating effects on sensitive skin, sub-health skin such as atopic dermatitis, etc.
Description
Technical Field
The invention relates to the technical field of biological medicines and personal care products, in particular to a composition for repairing a skin barrier and a preparation method and application thereof.
Background
The skin barrier in a narrow sense refers to a 'brick wall structure' of a sebum membrane and a cuticle, wherein the 'brick wall structure' of the cuticle is a composite structure composed of protein, lipid and the like, so that the skin barrier not only effectively prevents water from losing from the inside, but also provides a protective barrier for external stimulation and pathogens, protects the skin from being influenced by external substances, and has a great effect on maintaining the health of the skin. The healthy epidermal barrier mainly comprises: good keratinocytes, intact lipid layers and a well-defined bilayer structure of the lipid matrix. However, improper use of environment, diet and skin care products can easily cause damage to skin barrier, especially, water loss is too fast, and external toxic and harmful substances can easily invade human body to cause phenomena of dry, sensitive, inflammatory, aging and the like of skin.
Research shows that stratum corneum intercellular lipid plays an important role in maintaining the intact skin barrier, and meanwhile, ceramide is the main component of the stratum corneum intercellular lipid, accounts for 40-50% of the stratum corneum lipid, and plays an important role in maintaining the ordered arrangement of intercellular lipid and the healthy function of the skin barrier. Problem skin and sub-healthy skin with age, the loss of ceramide is accelerated, so it is important to develop skin care products that effectively supplement ceramide and promote the ordered arrangement of intercellular lipids.
From the perspective of cell biology, in order to adapt to complex environmental changes, a signal molecule capable of transmitting external stimuli to internal metabolic reactions is required, and calcium ions are one of important signal molecules in the human body. Calcium ions exist inside and outside the cell, the charged ions cannot freely pass through the cell membrane but need ion channel proteins on the cell membrane to transport, and external stimulation can adjust the ion concentration in the cell by applying opening and closing of the channel to influence the physiological activity of the cell. In normal skin epidermis, the concentration of calcium ions is not uniform, but has a specific concentration gradient, i.e. gradually decreases from the stratum corneum towards the basal layer. It has been found that high concentrations of calcium ions can promote keratinocyte differentiation, stratification and keratin formation. Calcium ions can repair skin barriers from inside to outside by influencing the integrity of cornification envelopes, the synthesis of structural lipids and skin surface lipids and the synthesis of natural moisturizing factors, so that the autonomous repair of the body cannot be realized by the participation of the calcium ions. The breakdown of the skin barrier means that the transdermal water (TEWL) value increases dramatically and water is largely lost, causing a rapid decrease in the extracellular calcium ion concentration in the epidermis. Therefore, proper calcium ion supplementation is also particularly important for sub-healthy skin and problem skin. Meanwhile, for skin with undamaged barrier, the function of the barrier can be obviously enhanced by enhancing the calcium ion gradient among epidermal cells.
The current cosmetics are more focused on repairing the sebum membrane of the skin. The invention has obvious effect on repairing the 'brick wall structure' of the cuticle besides repairing the skin sebum membrane.
Disclosure of Invention
In view of the above, the technical problem to be solved by the present invention is to provide a composition for repairing skin barrier, and a preparation method and an application thereof, wherein the composition of the present invention has a significant effect on enhancing and repairing skin barrier functions of healthy skin, sub-healthy skin, atopic dermatitis, and other problems.
The composition provided by the invention comprises a calcium ion compound, ceramide, cholesterol, hydrogenated lecithin, betaine, polyhydric alcohol, octyl dodecanol and water.
In the embodiment of the invention, the composition consists of the following components in percentage by mass:
in some embodiments, the preferred composition consists of the following components in parts by mass:
in the composition of the present invention:
the calcium ion compound is at least one selected from calcium chloride, calcium pyrrolidone carboxylate, calcium gluconate, EDTA disodium calcium, calcium aspartate and yeast/calcium fermentation product;
the ceramide is selected from at least one of ceramide 1, ceramide 2, ceramide 3, ceramide 4, ceramide 5, ceramide 6 II, ceramide 7, ceramide 8, ceramide 9 and ceramide-like;
the polyalcohol is at least one of glycerol, propylene glycol, butanediol, pentanediol, hexanediol, dipropylene glycol, methyl propanediol and PEG-8.
In some embodiments, in the composition:
the calcium ion compound is calcium chloride or calcium gluconate;
the ceramide is ceramide 1, ceramide 3 and ceramide 6;
the polyalcohol is glycerol and butanediol, or butanediol and propylene glycol, or glycerol and propylene glycol.
In one embodiment, the composition consists of water and ceramide, hydrogenated lecithin, cholesterol, octyldodecanol, polyol, and betaine. Wherein the ceramide is ceramide 3; the polyhydric alcohol is glycerol and propylene glycol. The mass ratio of the glycerol to the propylene glycol is 1: 1.
in this example, the composition consists of the following components in mass fraction:
in one embodiment, the composition is comprised of water, calcium ion compound, hydrogenated lecithin, cholesterol, octyldodecanol, polyol, betaine. Wherein the calcium ion compound is calcium chloride, and the polyalcohol is glycerol and propylene glycol. The mass ratio of the glycerol to the propylene glycol is 1: 1.
in this example, the composition consists of the following components in mass fraction:
in one embodiment, the composition consists of water and ceramide, calcium ion compound, hydrogenated lecithin, cholesterol, octyldodecanol, polyol, betaine. Wherein the ceramide is ceramide 3; the calcium ion compound is calcium chloride. The polyhydric alcohol is glycerol and propylene glycol. The mass ratio of the glycerol to the propylene glycol is 1: 1.
in this example, the composition consists of the following components in mass fraction:
in one embodiment, the composition consists of water and ceramide, hydrogenated lecithin, cholesterol, octyldodecanol, polyol, and betaine. Wherein, ceramide is ceramide 1; the polyhydric alcohols are glycerol and butanediol. The mass ratio of the glycerol to the butanediol is 1: 2.
in this example, the composition consists of the following components in mass fraction:
in one embodiment, the composition consists of water and hydrogenated lecithin, cholesterol, octyldodecanol, a polyol, calcium ions, and betaine. Wherein the calcium ion is derived from calcium chloride; the polyhydric alcohols are glycerol and butanediol. The mass ratio of the glycerol to the butanediol is 1: 2.
in this example, the composition consists of the following components in mass fraction:
in one embodiment, the composition consists of water and ceramide, hydrogenated lecithin, cholesterol, octyldodecanol, polyol, calcium ion, and betaine. Wherein, ceramide is ceramide 1, and calcium ion is derived from calcium chloride; the polyhydric alcohols are glycerol and butanediol. The mass ratio of the glycerol to the butanediol is 1: 2.
in this example, the composition consists of the following components in mass fraction:
in one embodiment, the composition consists of water and ceramide, hydrogenated lecithin, cholesterol, octyldodecanol, polyol, and betaine. Wherein the ceramide is ceramide 6. The polyhydric alcohol is butanediol and propylene glycol; the mass ratio of the propylene glycol to the butanediol is 3: 5.
in this example, the composition consists of the following components in mass fraction:
in one embodiment, the composition consists of water and hydrogenated lecithin, cholesterol, octyldodecanol, a polyol, a calcium ion compound, and betaine. Wherein the polyhydric alcohol is butanediol and propylene glycol; the mass ratio of the propylene glycol to the butanediol is 3: 5. the calcium ion compound is derived from calcium gluconate.
In this example, the composition consists of the following components in mass fraction:
in one embodiment, the composition consists of water and ceramide, hydrogenated lecithin, cholesterol, octyldodecanol, a polyol, a calcium ion compound, and betaine. Wherein the ceramide is ceramide 6. The polyhydric alcohol is butanediol and propylene glycol; the mass ratio of the propylene glycol to the butanediol is 3: 5. the calcium ion compound is derived from calcium gluconate.
In this example, the composition consists of the following components in mass fraction:
the composition provided by the invention comprises a calcium ion compound, ceramide, cholesterol, hydrogenated lecithin and betaine. The composition is used for repairing skin barriers, has a remarkable synergistic effect among components, can effectively supplement and promote the synthesis of lipid among skin cells, and can repair damaged skin and rebuild skin barriers. Meanwhile, the present invention provides an efficient preparation method of the above skin barrier repair composition. The composition has obvious relieving and treating effects on sensitive skin, sub-health skin such as atopic dermatitis, etc.
The preparation method of the composition comprises the following steps:
mixing ceramide, cholesterol, hydrogenated lecithin and octyldodecanol at 80-90 ℃, and stirring at 100rpm to prepare an oil phase;
mixing a calcium ion compound, betaine, polyhydric alcohol and water at 80-90 ℃, and stirring at 100rpm to prepare a water phase;
mixing the oil phase and the water phase, and homogenizing at high speed and high pressure to obtain the composition.
And cooling the homogenized composition to room temperature, wherein the room temperature is 18-30 ℃.
In some embodiments, the parameters of the high-speed high-pressure homogenization are: homogenizing under 1300bar pressure for 3 times. The resulting composition is a translucent or milky white body.
The composition or the composition prepared by the preparation method of the invention is applied to the preparation of water-replenishing and/or moisturizing cosmetics and/or medicines.
The composition or the composition prepared by the preparation method of the invention is applied to preparing cosmetics and/or medicines for repairing skin barriers.
The invention also provides a cosmetic and/or pharmaceutical product comprising the composition of the invention or the composition prepared by the preparation method of the invention.
The cosmetic of the present invention is a product which is applied to any part of the surface of the human body (skin, hair, nails, lips, etc.) by smearing, sprinkling, spraying or the like, so as to achieve the purposes of cleaning, perfuming, changing the appearance, correcting the odor of the human body, maintaining and keeping a good state. The cosmetic of the present invention refers to a cosmetic to be applied to the skin. The cosmetic and/or pharmaceutical preparation can be in the form of cream, lotion, cosmetic water, gel, facial mask, and spray.
In some embodiments, the cosmetic is in the form of a lotion, wherein the composition is present in an amount of 1% by weight.
The invention also provides a method for repairing a skin barrier by topically applying the cosmetic or pharmaceutical composition of the invention. The external application is smearing, spraying or pasting.
The composition provided by the invention comprises intercellular endogenous lipid such as ceramide and cholesterol, calcium ion compounds and the like, and experiments show that the two can play a good synergistic effect. Not only supplements intercellular lipid lost due to barrier damage, but also plays a good role in self-repairing of the skin barrier by adjusting the concentration of calcium ions. Has obvious effect on strengthening and repairing the barrier function of healthy skin, sub-healthy skin, atopic dermatitis and other problems.
The composition of the present invention has at least the following beneficial effects:
(1) the pH value of the skin barrier repair composition is 5-7.5, so that the skin barrier can be quickly repaired, the natural moisturizing factors and lipid structures are quickly and orderly arranged, external stimulation is resisted, and the problem skin is repaired. (2) The product has good appearance and texture, and has good appearance and moisture retention. (3) The product has excellent high and low temperature stability and certain consistency, and meets good user experience.
Drawings
FIG. 1 shows the average particle size distribution of the composition;
Detailed Description
The invention provides a composition for repairing skin barrier, a preparation method and application thereof, and a person skilled in the art can appropriately modify process parameters for realization by referring to the content. It is expressly intended that all such similar substitutes and modifications which would be obvious to one skilled in the art are deemed to be included in the invention. While the methods and applications of this invention have been described in terms of preferred embodiments, it will be apparent to those of ordinary skill in the art that variations and modifications in the methods and applications described herein, as well as other suitable variations and combinations, may be made to implement and use the techniques of this invention without departing from the spirit and scope of the invention.
The test materials adopted by the invention are all common commercial products and can be purchased in the market.
The invention is further illustrated by the following examples:
example 1
TABLE 1 groups 1-9 and CK control formula (unit: wt%)
The preparation method comprises the following steps:
the first step is as follows: preparing an oil phase mixture: mixing ceramide, cholesterol, hydrogenated lecithin and octyldodecanol together, heating in water bath to 85 deg.C, stirring at 100rpm to ensure uniform mixing of oil phase. And (5) standby.
The second step is that: preparation of an aqueous phase mixture: the calcium ion compound, betaine, polyol and water are mixed together. Heating in water bath, heating to 85 deg.C, stirring at 100rpm to ensure the water phase is dissolved and transparent. And (5) standby.
The third step: the oil phase mixture was added to the aqueous phase and prepared by feeding through a high speed high pressure homogenizer (parameter 1300bar pressure cycle homogenization 3 times). Finally preparing the translucent or milky white body.
The pH value of the prepared composition is 5-7.5 through detection; the average particle size was 322 nm.
Experiment I, stability verification
The compositions prepared in examples 1 to 9 and CK were placed in a refrigerator (-10 ℃) and an oven (45 ℃) at room temperature, respectively, and stability was examined for 0 day, 3 days, 7 days, 15 days, and 30 days to observe whether or not each composition had oil-water separation.
TABLE 2 stability test results
The results show that the stability of each composition is good.
Experiment two, effect verification
2.1 test sample preparation
The compositions prepared in the examples 1 to 9 and CK were added to purified water, respectively, and the mass fraction of the composition in each composition solution was 1%.
2.2 percutaneous moisture loss TEWL test
According to the A.Fick diffusion principle, the quality of the skin barrier is characterized by measuring the change of the moisture vapor pressure close to the surface of the skin. TEWL value in units of g/(m)2H). TE of skinThe lower the WL value, the better the barrier function against water loss, and the worse the other way round.
(1) And (3) testing environmental conditions: the testing environment temperature is 22 +/-1 ℃, the humidity is 50 +/-5%, and real-time dynamic detection is carried out;
(2) the volunteer requires: 90 volunteers were recruited, female in gender, between 18-50 years of age, and were healthy without taking medication.
(3) The testing steps are as follows: volunteers were randomly divided into 9 groups, and test groups 1-9 were given to groups 1-9 and blank compositions in sequence, with 10 subjects in each group. The test site was the face. The subjects in each group were not allowed to apply additional cosmetics or skin care products during the test period. The test instrument selects a skin moisture loss TEWL test probe for the skin test instrument, and the test samples and the blank control are randomly distributed on the left face and the right face. The blank value of each test area is measured, then the test subject is specified to be uniformly coated in the test area according to the specified usage amount and flow, the test time is 4 weeks, and the test results of the change of the skin moisture loss content before use, 2 weeks, 4 weeks, the test area and the blank control area are respectively measured after use are shown in table 3:
the TEWL change rate is calculated as:
TABLE 3 skin moisture loss values
The results show that groups 3, 6 and 9 have good skin moisture loss inhibiting effect, indicating that the composition can have moisturizing effect and improve skin barrier effect.
Evaluation of effects of Experimental three products
(1) Evaluation sample preparation
The compositions of examples 1 to 9 and the blank were added to purified water, respectively, and the mass fraction of the composition in each composition solution was 1%.
(2) Requirements of volunteers
About 200 volunteers were recruited, female in gender, between 18-50 years of age, and healthy without taking drugs.
(2) Test method
Volunteers were randomly divided into 10 groups, and test groups 1-10 were given different composition solutions in sequence, and each group had 20 subjects. The first test site was the face. Subjects, collecting basic information and taking clinical pictures, daily skin cleansing, and topical application of different compositions for 2 weeks, 2 times daily. Other external ointment or skin care products cannot be used during clinical trials of the tested part. Before use, the patients were observed at the 1 st and 2 nd weeks after use.
(1) Evaluation method
Three researchers independently score objective symptoms (desquamation and erythema), and take the average value of the three; patients subjectively scored subjective symptoms (dryness, burning, itching), each by a 0-10 scale. Photographs of the central part, left and right sides, and VISIA were taken before, after 1 week, and after 2 weeks of use. The clinical symptom score of the subject is obviously improved when the improvement rate is more than 75 percent, moderate improvement is realized when the improvement rate is between 25 and 75 percent, and no improvement is judged when the improvement rate is less than 25 percent. The results were then collected and the test data were summarized in table 4.
TABLE 4 score improvement rates of subjective and objective symptoms before and after use
As can be seen from Table 4, the samples of groups 3, 6 and 9 of the present invention containing the liposomes of ceramide and calcium ion compounds were superior to those of the other groups, and the samples of groups 3, 6 and 9 containing the liposomes of ceramide and calcium ion compounds were significantly improved in facial skin desquamation, erythema, dryness, burning and itching after two weeks of continuous use.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that it is obvious to those skilled in the art that various modifications and improvements can be made without departing from the principle of the present invention, and these modifications and improvements should also be considered as the protection scope of the present invention.
Claims (8)
1. A composition comprises calcium ion compound, ceramide, cholesterol, hydrogenated lecithin, betaine, polyol, octyl dodecanol and water.
2. The composition according to claim 1, which is characterized by comprising the following components in percentage by mass:
3. the composition according to claim 2, which is characterized by comprising the following components in percentage by mass:
4. the composition according to any one of claims 1 to 3,
the calcium ion compound is at least one selected from calcium chloride, calcium pyrrolidone carboxylate, calcium gluconate, EDTA disodium calcium, calcium aspartate and yeast/calcium fermentation product;
the ceramide is selected from at least one of ceramide 1, ceramide 2, ceramide 3, ceramide 4, ceramide 5, ceramide 6 II, ceramide 7, ceramide 8, ceramide 9 and ceramide-like;
the polyalcohol is at least one of glycerol, propylene glycol, butanediol, pentanediol, hexanediol, dipropylene glycol, methyl propanediol and PEG-8.
5. A process for preparing a composition as claimed in any one of claims 1 to 4, comprising:
mixing ceramide, cholesterol, hydrogenated lecithin and octyldodecanol at 80-90 ℃, stirring at 100rpm to obtain an oil phase
Mixing a calcium ion compound, betaine, polyhydric alcohol and water at 80-90 ℃, and stirring at 100rpm to prepare a water phase;
mixing the oil phase and the water phase, and homogenizing at high speed and high pressure to obtain the composition.
6. The preparation method according to claim 5, wherein the parameters of the high-speed high-pressure homogenization are as follows: 1300 bar.
7. Use of a composition according to any one of claims 1 to 4 or a composition prepared by a preparation process according to any one of claims 5 to 6 for the preparation of a water-replenishing and/or moisturizing cosmetic and/or pharmaceutical product.
8. A cosmetic and/or pharmaceutical product comprising the composition according to any one of claims 1 to 4 or the composition prepared by the preparation method according to any one of claims 5 to 6.
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