CN108379096A - A kind of keratoderma repairs essence microcapsules and preparation method thereof - Google Patents

A kind of keratoderma repairs essence microcapsules and preparation method thereof Download PDF

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Publication number
CN108379096A
CN108379096A CN201810530506.1A CN201810530506A CN108379096A CN 108379096 A CN108379096 A CN 108379096A CN 201810530506 A CN201810530506 A CN 201810530506A CN 108379096 A CN108379096 A CN 108379096A
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parts
keratoderma
microcapsules
capsule
essence
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金仲恩
全春兰
张帆
喻国贞
欧阳智琨
陈晋纳
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Suzhou Cosmetic New Materials Co Ltd
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Suzhou Cosmetic New Materials Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0241—Containing particulates characterized by their shape and/or structure
    • A61K8/025—Explicitly spheroidal or spherical shape
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/55—Phosphorus compounds
    • A61K8/553—Phospholipids, e.g. lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/63—Steroids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/678—Tocopherol, i.e. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/56—Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/592—Mixtures of compounds complementing their respective functions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/60—Particulates further characterized by their structure or composition
    • A61K2800/61—Surface treated
    • A61K2800/62—Coated
    • A61K2800/622—Coated by organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/60—Particulates further characterized by their structure or composition
    • A61K2800/65—Characterized by the composition of the particulate/core
    • A61K2800/652—The particulate/core comprising organic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Molecular Biology (AREA)
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  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Cosmetics (AREA)

Abstract

The invention discloses a kind of keratodermas to repair essence microcapsules and preparation method thereof, microcapsules are the transparent sphere soft capsule of nucleocapsid, wherein cyst wall is sericin shell membrane, capsule-core is that keratoderma repairs essence, and the mass ratio of cyst wall and capsule-core is 1~3:1, a diameter of 1~5mm of microcapsules；By weight, the keratoderma reparation essence includes：1~28 part of Cer EOS, 8~19 parts of cholesterol, 5~18 parts of lecithin, 3-Hydroxyretinol~7 part, 1~8 part of vitamin E, 1~3 part of histidine, 1~3 part of lysine, 1~3 part of arginine, 3~9 parts of sodium hyaluronate, 3~11 parts of Sweet Almond Oil, 2~9 parts of jojoba oil.It cooperates with and plays a role between keratoderma reparation essence microcapsules each component of the present invention, promote the absorptivity of the raw materials such as ceramide, cholesterol；It can be good at incorporating space between cells, accelerate skin damage cuticula to restore its barrier function, so as to improve skin condition.

Description

A kind of keratoderma repairs essence microcapsules and preparation method thereof
Technical field
The invention belongs to cosmetic technical fields, are related to a kind of basic facial treatment repair, specially a kind of keratoderma Repair essence microcapsules and preparation method thereof.
Background technology
Cuticula is located at the outermost layer of skin, and from physiological significance, cuticula is to prevent Skin Cell internal moisture It loses, the erosion of external microbe and chemical substance provides extremely effective barrier action.In general, cuticula is by 12~16 The horn cell of the flat acellular core of layer overlaps each other, mutually restriction arranges, and folder is with lipid base between each layer horn cell Matter forms the unique structure of cuticula.The main lipid of cuticula include ceramide (40-50%), cholesterol (about 25%), Free fatty (about 25%), cholesterol sulfate (about 5%) and a small amount of phosphoric acid etc..Newest research thinks, skin aging, angle Cell plastid hydratability changes, skin surface pH value variation etc. such as can cause the imbalance of cutin layer function, and dry, is coarse at the skins Skin problem is then the external manifestation of cuticula functional disturbance, cannot be changed well if merely kept the skin wet to skin at this time Become the drying regime of skin, and what is more important reaches recovery and the normal cutin of maintenance by supplementing the lipid components of cuticula Layer barrier function.
Stratum corneum barrier reparation is carried out with suitable physiological lipid in time to be very important, but in the prior art, Due to the problems such as absorbing, permeating, the physiological lipid ceramide of supplement is caused, the raw material availabilities such as cholesterol are relatively low, diagonally Matter layer barrier repairing effect also fails to reach satisfactory degree.
Invention content
Present invention solves the technical problem that：For overcome the deficiencies in the prior art, obtain one kind can promote ceramide, The absorptivity of the raw materials such as cholesterol improves the basic facial treatment repair of pachylosis, and the present invention provides a kind of keratodermas Repair essence microcapsules and preparation method thereof.
Technical solution：A kind of keratoderma reparation essence microcapsules, microcapsules are that the transparent sphere of nucleocapsid is soft Capsule, wherein cyst wall is sericin shell membrane, and capsule-core is that keratoderma repairs essence, and the mass ratio of cyst wall and capsule-core is 1 ~3:1, a diameter of 1~5mm of microcapsules；By weight, the keratoderma reparation essence includes：Cer EOS 1 ~28 parts, 8~19 parts of cholesterol, 5~18 parts of lecithin, 3~7 parts of vitamin A, 1~8 part of vitamin E, histidine 1~3 Part, 1~3 part of lysine, 1~3 part of arginine, 3~9 parts of sodium hyaluronate, 3~11 parts of Sweet Almond Oil, 2~9 parts of jojoba oil.
Preferably, microcapsules are the transparent sphere soft capsule of nucleocapsid, wherein cyst wall is sericin shell membrane, capsule-core For keratoderma reparation essence, the mass ratio of cyst wall and capsule-core is 1:1, a diameter of 1mm of microcapsules；By weight, The keratoderma repairs essence：1 part of Cer EOS, 8 parts of cholesterol, 5 parts of lecithin, 3 parts of vitamin A, dimension Raw 1 part of element E, 1 part of histidine, 1 part of lysine, 1 part of arginine, 3 parts of sodium hyaluronate, 3 parts of Sweet Almond Oil, 2 parts of jojoba oil.
Preferably, microcapsules are the transparent sphere soft capsule of nucleocapsid, wherein cyst wall is sericin shell membrane, capsule-core For keratoderma reparation essence, the mass ratio of cyst wall and capsule-core is 2:1, a diameter of 3mm of microcapsules；By weight, The keratoderma repairs essence：2 parts of Cer NS, 15 parts of cholesterol, 14 parts of lecithin, 4 parts of vitamin A, 5 parts of vitamin E, 2 parts of histidine, 2 parts of lysine, arginase 12 part, 5 parts of sodium hyaluronate, 7 parts of Sweet Almond Oil, 6 parts of jojoba oil.
Preferably, microcapsules are the transparent sphere soft capsule of nucleocapsid, wherein cyst wall is sericin shell membrane, capsule-core For keratoderma reparation essence, the mass ratio of cyst wall and capsule-core is 3:1, a diameter of 5mm of microcapsules；By weight, The keratoderma repairs essence：8 parts of Cer NS, 19 parts of cholesterol, 18 parts of lecithin, 7 parts of vitamin A, 8 parts of vitamin E, 3 parts of histidine, 3 parts of lysine, 3 parts of arginine, 9 parts of sodium hyaluronate, 11 parts of Sweet Almond Oil, 9 parts of jojoba oil.
Any description above keratoderma repairs the preparation method of essence microcapsules, and the method includes following steps Suddenly：
(1) the sericin solution for preparing the metal ion Han 220~260mmol/L adjusts pH to 6~7, after lasting stirring It is placed in 30~37 DEG C of insulating box and reacts；
(2) solution after reacting step (1) centrifuges precipitation, be washed with deionized remove extra metal from Then each component of capsule-core is added in son, lasting stirring, which is placed in 30~37 DEG C of insulating box, reacts 6~12 hours；
(3) product after deionized water washing step (2) reaction is used, is placed in vacuum drying chamber dry, you can be made.
Preferably, the mass percent concentration of sericin solution is 4~8%.
Preferably, the metal ion is any one in calcium ion, magnesium ion, copper ion, zinc ion.
Preferably, the molecular weight of the sericin is 10000~80000Da.
Advantageous effect：(1) it cooperates with and plays a role between keratoderma reparation essence microcapsules each component of the present invention, Promote the absorptivity of the raw materials such as ceramide, cholesterol；(2) keratoderma reparation essence microcapsules of the present invention can Space between cells is incorporated well, accelerates skin damage cuticula to restore its barrier function, so as to improve skin condition.
Specific implementation mode
Embodiment 1
A kind of keratoderma reparation essence microcapsules, microcapsules are the transparent sphere soft capsule of nucleocapsid, wherein Cyst wall is sericin shell membrane, and capsule-core is that keratoderma repairs essence, and the mass ratio of cyst wall and capsule-core is 1:1, microcapsules A diameter of 1mm；By weight, the keratoderma reparation essence includes：1 part of Cer EOS, 8 parts of cholesterol, ovum Phosphatidase 5 part, 3 parts of vitamin A, 1 part of vitamin E, 1 part of histidine, 1 part of lysine, 1 part of arginine, 3 parts of sodium hyaluronate, sweet tea apricot Benevolence oil 3 parts, 2 parts of jojoba oil.
The keratoderma repairs the preparation method of essence microcapsules, the described method comprises the following steps：
(1) the sericin solution for preparing the metal ion containing 220mmol/L, adjusts pH to 6, and lasting stirring is placed on 30 DEG C Insulating box in react；
(2) solution after reacting step (1) centrifuges precipitation, be washed with deionized remove extra metal from Then each component of capsule-core is added in son, lasting stirring, which is placed in 30 DEG C of insulating box, reacts 6 hours；
(3) product after deionized water washing step (2) reaction is used, is placed in vacuum drying chamber dry, you can be made.
The mass percent concentration of sericin solution is 4%.
The metal ion is any one in calcium ion, magnesium ion, copper ion, zinc ion.
The molecular weight of the sericin is 10000~80000Da.
Embodiment 2
A kind of keratoderma reparation essence microcapsules, microcapsules are the transparent sphere soft capsule of nucleocapsid, wherein Cyst wall is sericin shell membrane, and capsule-core is that keratoderma repairs essence, and the mass ratio of cyst wall and capsule-core is 2:1, microcapsules A diameter of 3mm；By weight, the keratoderma reparation essence includes：2 parts of Cer NS, 15 parts of cholesterol, 14 parts of lecithin, 4 parts of vitamin A, 5 parts of vitamin E, 2 parts of histidine, 2 parts of lysine, arginase 12 part, 5 parts of sodium hyaluronate, sweet tea 7 parts of apricot kernel oil, 6 parts of jojoba oil.
The keratoderma repairs the preparation method of essence microcapsules, the described method comprises the following steps：
(1) the sericin solution for preparing the metal ion containing 240mmol/L, adjusts pH to 6.5, and lasting stirring is placed on 35 DEG C insulating box in react；
(2) solution after reacting step (1) centrifuges precipitation, be washed with deionized remove extra metal from Then each component of capsule-core is added in son, lasting stirring, which is placed in 34 DEG C of insulating box, reacts 8 hours；
(3) product after deionized water washing step (2) reaction is used, is placed in vacuum drying chamber dry, you can be made.
The mass percent concentration of sericin solution is 6%.
The metal ion is any one in calcium ion, magnesium ion, copper ion, zinc ion.
The molecular weight of the sericin is 10000~80000Da.
Embodiment 3
A kind of keratoderma reparation essence microcapsules, microcapsules are the transparent sphere soft capsule of nucleocapsid, wherein Cyst wall is sericin shell membrane, and capsule-core is that keratoderma repairs essence, and the mass ratio of cyst wall and capsule-core is 3:1, microcapsules A diameter of 5mm；By weight, the keratoderma reparation essence includes：8 parts of Cer NS, 19 parts of cholesterol, 18 parts of lecithin, 7 parts of vitamin A, 8 parts of vitamin E, 3 parts of histidine, 3 parts of lysine, 3 parts of arginine, 9 parts of sodium hyaluronate, sweet tea 11 parts of apricot kernel oil, 9 parts of jojoba oil.
The keratoderma repairs the preparation method of essence microcapsules, the described method comprises the following steps：
(1) the sericin solution for preparing the metal ion containing 260mmol/L, adjusts pH to 7, and lasting stirring is placed on 37 DEG C Insulating box in react；
(2) solution after reacting step (1) centrifuges precipitation, be washed with deionized remove extra metal from Then each component of capsule-core is added in son, lasting stirring, which is placed in 37 DEG C of insulating box, reacts 12 hours；
(3) product after deionized water washing step (2) reaction is used, is placed in vacuum drying chamber dry, you can be made.
The mass percent concentration of sericin solution is 8%.
The metal ion is any one in calcium ion, magnesium ion, copper ion, zinc ion.
The molecular weight of the sericin is 10000~80000Da.
Essence microcapsules are repaired to the keratoderma that Examples 1 to 3 prepares to be detected, as a result such as following table institute Show.Wherein, moisture of skin test is measured using moisture of skin tester, and principle is：Since water has very high dielectric normal Number, significantly larger than other substances, after test probe and skin contact, the variation of capacitance can reflect in keratoderma Water content, water content of stratum corneum is higher, and capacitance is also higher.It is all test constant temperature, constant humidity laboratory in carry out.
Embodiment 1 Embodiment 2 Embodiment 3
Embedding rate/% 95 99 97
Skin moisture content 24.5 28.5 26.5

Claims (8)

1. a kind of keratoderma repairs essence microcapsules, which is characterized in that microcapsules are that the transparent sphere of nucleocapsid is soft Capsule, wherein cyst wall is sericin shell membrane, and capsule-core is that keratoderma repairs essence, and the mass ratio of cyst wall and capsule-core is 1 ~3:1, a diameter of 1~5mm of microcapsules；By weight, the keratoderma reparation essence includes：Cer EOS 1 ~28 parts, 8~19 parts of cholesterol, 5~18 parts of lecithin, 3~7 parts of vitamin A, 1~8 part of vitamin E, histidine 1~3 Part, 1~3 part of lysine, 1~3 part of arginine, 3~9 parts of sodium hyaluronate, 3~11 parts of Sweet Almond Oil, 2~9 parts of jojoba oil.
2. a kind of keratoderma according to claim 1 repairs essence microcapsules, which is characterized in that microcapsules are core The transparent sphere soft capsule of shell structure, wherein cyst wall is sericin shell membrane, and capsule-core is that keratoderma repairs essence, capsule The mass ratio of wall and capsule-core is 1:1, a diameter of 1mm of microcapsules；By weight, the keratoderma repairs essence packet It includes：1 part of Cer EOS, 8 parts of cholesterol, 5 parts of lecithin, 3 parts of vitamin A, 1 part of vitamin E, 1 part of histidine, lysine 1 Part, 1 part of arginine, 3 parts of sodium hyaluronate, 3 parts of Sweet Almond Oil, 2 parts of jojoba oil.
3. a kind of keratoderma according to claim 1 repairs essence microcapsules, which is characterized in that microcapsules are core The transparent sphere soft capsule of shell structure, wherein cyst wall is sericin shell membrane, and capsule-core is that keratoderma repairs essence, capsule The mass ratio of wall and capsule-core is 2:1, a diameter of 3mm of microcapsules；By weight, the keratoderma repairs essence packet It includes：2 parts of Cer NS, 14 parts of lecithin, 4 parts of vitamin A, 5 parts of vitamin E, 2 parts of histidine, relies ammonia at 15 parts of cholesterol 2 parts of acid, arginase 12 part, 5 parts of sodium hyaluronate, 7 parts of Sweet Almond Oil, 6 parts of jojoba oil.
4. a kind of keratoderma according to claim 1 repairs essence microcapsules, which is characterized in that microcapsules are core The transparent sphere soft capsule of shell structure, wherein cyst wall is sericin shell membrane, and capsule-core is that keratoderma repairs essence, capsule The mass ratio of wall and capsule-core is 3:1, a diameter of 5mm of microcapsules；By weight, the keratoderma repairs essence packet It includes：8 parts of Cer NS, 18 parts of lecithin, 7 parts of vitamin A, 8 parts of vitamin E, 3 parts of histidine, relies ammonia at 19 parts of cholesterol 3 parts of acid, 3 parts of arginine, 9 parts of sodium hyaluronate, 11 parts of Sweet Almond Oil, 9 parts of jojoba oil.
5. any keratoderma of Claims 1 to 4 repairs the preparation method of essence microcapsules, which is characterized in that institute The method of stating includes the following steps：
(1) the sericin solution for preparing the metal ion Han 220~260mmol/L, adjusts pH to 6~7, and lasting stirring is placed on It is reacted in 30~37 DEG C of insulating box；
(2) solution after reacting step (1) centrifuges precipitation, is washed with deionized and removes extra metal ion, so The each component of capsule-core is added afterwards, lasting stirring, which is placed in 30~37 DEG C of insulating box, reacts 6~12 hours；
(3) product after deionized water washing step (2) reaction is used, is placed in vacuum drying chamber dry, you can be made.
6. keratoderma according to claim 5 repairs the preparation method of essence microcapsules, which is characterized in that silk gum The mass percent concentration of protein solution is 4~8%.
7. keratoderma according to claim 5 repairs the preparation method of essence microcapsules, which is characterized in that described Metal ion is any one in calcium ion, magnesium ion, copper ion, zinc ion.
8. keratoderma according to claim 5 repairs the preparation method of essence microcapsules, which is characterized in that described The molecular weight of sericin is 10000~80000Da.
CN201810530506.1A 2018-05-29 2018-05-29 A kind of keratoderma repairs essence microcapsules and preparation method thereof Withdrawn CN108379096A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110638696A (en) * 2019-10-25 2020-01-03 中南大学湘雅医院 Composition for repairing skin barrier and preparation method and application thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110638696A (en) * 2019-10-25 2020-01-03 中南大学湘雅医院 Composition for repairing skin barrier and preparation method and application thereof

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