KR20090054777A - Composition for controlling ph of skin and cosmetics comprising the same - Google Patents

Abstract

A composition for regulating skin pH concentration is provided to regulate the skin pH concentration with weak acidity using lactic acid, pyrrolidone carboxylic acid and amino acid, and enhance the elasticity and moisturization. A composition for regulating skin pH concentration comprises two or more components selected from lactic acid or its salt, pyrrolidone carboxylic acid or its salt, and amino acid. The lactic acid salt is one or more selected from sodium lactate, lactic acid copper, lactic acid aluminum, magnesium lactate and calcium lactate. The pyrrolidone carboxylic acid is one or more selected from sodium pyrrolidone carboxylic acid, potassium pyrrolidone carboxylic acid, pyrrolidone carboxylic acid copper, pyrrolidone carboxylic acid calcium, pyrrolidone carboxylic acid aluminum and pyrrolidone carboxylic acid zinc. The pyrrolidone carboxylic acid or its salt is contained in 0.01-10 weight part based on 100 weight part of total composition. The amino acid is one or more selected from lysine, histidine, arginine, aspartic acid, threonine, serine, glutamic acid, proline, glycine, alanine, and the methionine, isoleucine, leucine, tyrosine, phenylalanine, half cysteine, cysteine, asparagine, glutamine and tryptophan.

Description

Composition for controlling pH of skin and cosmetics comprising the same}

The present invention relates to a composition for adjusting the pH of the skin and a cosmetic comprising the same, more specifically lactic acid or a salt thereof; Pyrrolidone carboxylic acid or a salt thereof; And it relates to a composition for adjusting the pH of the skin comprising two or more components selected from the group consisting of amino acids and skin moisturizing cosmetics comprising the same.

The stratum corneum (SC) of the skin is present in the outermost layer of the skin and is an important part of the human body because it is in direct contact with the external environment.

The stratum corneum basically consists of keratinocytes and lipids between keratinocytes, and other epidermal lipids and natural moisturizing factor (NMF). Keratinocytes are differentiated in the basal layer of the epidermis and are keratinized cells, consisting of a protein called keratin, and the interstitial lipids fill between the keratinocytes and are composed of lipid components such as ceramide, cholesterol, and fatty acids. The keratinocyte lipids form lamellar liquid crystal structures and are responsible for the skin's flexibility, moisturizing and protective functions. The structure of lipids between keratinocytes and keratinocytes can be explained by a two compartment model. The two compartment models are also referred to as brick and mortar models, compared to the mortar, which is the brick that builds the brick house and the bonding material between them. This unique structure exhibits a skin barrier function, a very important function of the skin. That is, the barrier function prevents the invasion of foreign substances from the outside and at the same time prevents the loss of water, electrolytes, and the like to the outside of the body, and maintains moisture in the stratum corneum to give skin elasticity, flexibility, and moisturizing feeling.

However, if the pH balance of the skin is broken, the activity of lipolytic enzymes is lowered, and harmful bacteria may proliferate, leading to a weakening of the skin barrier function. This weakening of the skin barrier function can be a major cause of various skin problems and chronic sensitive skin, dry skin, and atopic skin.

Although the pH of the skin varies from person to person, most of them show mild acidity of 4.5 to 6.5, and more normal skin pH is 5.0 to 5.5. Maintaining weakly acidic pH as described above is an important factor for healthy skin. The reason is that lipases, which are involved in the synthesis of lipids that function as skin barriers in a weakly acidic environment, are activated, and the weakly acidic skin surface inhibits bacterial growth such as bacteria and prevents weakening of skin barrier function. Because. Therefore, it is required to keep the pH of the skin weakly acid for healthy skin.

For the purpose of restoring the skin barrier function, Japanese Patent Laid-Open No. 2001-261520 discloses a skin cosmetic containing ceramide and tannin, and Japanese Patent Laid-Open No. 2001-261543 discloses a eucalyptus extract and a ginger extract which is a promoter of ceramide production; And a skin cosmetic containing tannin, and Japanese Patent Laid-Open No. 2002-114666 discloses a skin cosmetic containing a diamide, a water-soluble moisturizer (polyhydric alcohol), and a keratinocyte fat component (ceramide, etc.). However, the main purpose is to promote the synthesis of ceramide, which is one of keratinocyte lipids, and there is a problem that the repair effect of the skin barrier function is insufficient, and the durability and prevention are inferior.

The present invention has been made in consideration of the above-described prior art, and the present inventors are present in the stratum corneum and have a feature of absorbing water from the surrounding environment, and a natural moisture factor (NMF), which is a very important material for maintaining moisture in the stratum corneum. When the pH of the skin is adjusted with lactic acid, pyrrolidone carboxylic acid, and / or amino acids, which are natural pH regulators, which make up a large proportion of them, the moisturizing and elasticity of the skin are greatly improved by synergism of the components. It has been found that the present invention has been completed.

Accordingly, an object of the present invention is to provide lactic acid or a salt thereof; Pyrrolidone carboxylic acid or a salt thereof; And it provides a composition for adjusting the pH of the skin comprising two or more components selected from the group consisting of amino acids.

Still another object of the present invention is to provide a skin moisturizing cosmetic comprising the composition for adjusting the pH of the skin.

The present invention as a means for solving the above problems, lactic acid or a salt thereof; Pyrrolidone carboxylic acid or a salt thereof; And it provides a composition for adjusting the pH of the skin comprising two or more components selected from the group consisting of amino acids.

The lactic acid salt contained in the composition for adjusting pH of the skin is preferably at least one selected from the group consisting of sodium lactate, copper lactate, aluminum lactate, magnesium lactate, and calcium lactate, and the content of lactic acid or its salt is 100 parts by weight of the total composition. It is preferable that it is 0.01-10.

Pyrrolidone carboxylic acid salts contained in the composition for adjusting the pH of the skin include sodium pyrididone carboxylate, potassium pyrididone carboxylate, copper pyrididone carboxylic acid, calcium pyrididone carboxylate, aluminum pyrididone carboxylate, and pyrididone carboxylic acid It is preferably at least one selected from the group consisting of zinc, and the content of pyrrolidone carboxylic acid or salt thereof is preferably 0.01 to 10 based on 100 parts by weight of the total composition.

Amino acids included in the composition for pH adjustment of the skin are lysine, histidine, arginine, aspartic acid, threonine, serine, glutamic acid, proline, glycine, alanine, valine, methionine, isoleucine, leucine, tyrosine, phenylalanine, halcine, cysteine, It is preferably at least one selected from the group consisting of asparagine, glutamine, and tryptophan, and the content of amino acid is preferably 0.01 to 10 based on 100 parts by weight of the total composition.

The present invention as another means for solving the above problems, provides a skin moisturizing cosmetic comprising a composition for adjusting the pH of the skin.

The composition for adjusting the pH of the skin according to the present invention adjusts the pH of the skin to weak acidity, activates the lipid hydrolytic enzymes involved in the synthesis of lipids that function as a skin barrier, and inhibits bacterial growth such as bacteria on the skin surface or infection. To prevent weakening of the skin barrier function. In addition, the skin moisturizing cosmetic containing the same increases the elasticity, flexibility and moisturizing of the skin.

The present invention is lactic acid or salts thereof; Pyrrolidone carboxylic acid or a salt thereof; And it relates to a composition for adjusting the pH of the skin comprising two or more components selected from the group consisting of amino acids.

The composition for adjusting the pH of the skin adjusts the pH of the skin to weak acidity, activates a lipolytic enzyme involved in the synthesis of lipids that function as a skin barrier, inhibits the growth and infection of bacteria such as bacteria on the skin surface, Prevents weakening of barrier function

Each component of the composition for adjusting the pH of the skin is a natural pH regulator, there is no irritation to the skin. In addition, in the present invention, by mixing two or more kinds of each component, each component causes synergy, and the pH control ability of the skin is superior to that of each component alone. Although it is not specifically limited, In this invention, lactic acid or its salt; Pyrrolidone carboxylic acid or a salt thereof; And all amino acids.

Hereinafter, each component of the composition for adjusting pH of the skin according to the present invention will be described in more detail.

Lactic acid or its salts

Composition for pH adjustment of the skin of the present invention is characterized in that it comprises lactic acid or a salt thereof. In the present invention, any one of the above components may be included alone or two or more.

Lactic acid is a natural pH regulator that is present in the stratum corneum of the skin and accounts for about 12% of the natural moisturizing factor (NMF), an important substance for maintaining the moisture in the stratum corneum.

Lactic acid salts may be present in various forms, but is not limited thereto. Lactic acid salts that may be used in the present invention include sodium lactate, copper lactate, aluminum lactate, and magnesium lactate. lactate), and calcium lactate (Calcium lactate) is preferably at least one selected from the group consisting of.

Lactic acid or salts thereof that can be used in the present invention can be obtained in nature or synthesized through various chemical methods known in the art.

The content of lactic acid or salts thereof in the present invention is preferably 0.01 to 10 parts by weight based on 100 parts by weight of the total composition. If the content is less than 0.01 parts by weight can not be obtained by the use of lactic acid, if it exceeds 10 parts by weight of the skin pH is excessively lowered may be rather irritating to the skin, it is difficult to apply to various forms of formulation .

Pyrilidone  Carboxylic acids or salts thereof

Composition for pH adjustment of the skin of the present invention is characterized in that it comprises pyrrolidone carboxylic acid or a salt thereof. In the present invention, any one of the above components may be included alone or two or more.

Pyrrolidone carboxylic acid (hereinafter referred to as 'PCA') is a natural pH regulator that is present in the stratum corneum of the skin and accounts for about 12% of the natural moisture factor (NMF), an important substance for maintaining the moisture of the stratum corneum. .

Pyrilidone carboxylic acid is synthesized from glutamic acid present in the epithelium, colorless and tasteless, and stable over a wide range of temperatures and pH.

Pyrilidone carboxylic acid salts exist mainly in the form of sodium salts or potassium salts and show excellent moisturizing effect. Pyrrolidone carboxylic acid salts are easily decomposed in vivo, and as a natural moisturizing factor, the moisturizing power is superior to glycerin, is non-irritating and non-toxic, and does not cause allergy.

Pyrrolidone carboxylic acid salts may be present in various forms, but is not limited thereto, the pyrrolidone carboxylic acid salts usable in the present invention may be sodium pyrilidone sodium carboxylate (Sodium PCA), pyrilidone potassium carboxylate (Potassium PCA), It is preferred that it is at least one selected from the group consisting of copper pyridone carboxylate (Copper PCA), pyridyldonate calcium carboxylate (Calcium PCA), pyridydonate aluminum carboxylate (Aluminum PCA), and pyrididone zinc carboxylate (Zinc PCA). .

Pyrrolidone carboxylic acid or salts thereof that can be used in the present invention can be obtained in nature, or synthesized through various chemical methods known in the art.

In the present invention, the content of pyrrolidone carboxylic acid or a salt thereof is preferably 0.01 to 10 parts by weight based on 100 parts by weight of the total composition. When the content is less than 0.01 parts by weight, the effect of the use of pyrrolidone carboxylic acid is not obtained, when it exceeds 10 parts by weight, the feeling and stability is lowered, it is difficult to apply to various types of formulations.

amino acid

Composition for adjusting the pH of the skin of the present invention is characterized in that it comprises amino acids.

Amino acid is a major component of the protein tissues that make up the body and is also a component of enzymes and hormones that are involved in metabolism in the body and play a physiological function. According to its structure, there are about 20 kinds of amino acids, and there are amino acids made in the body, while some amino acids (essential amino acids) are not synthesized in the body.

The stratum corneum, the largest part of the body's tissue, also contains a certain percentage of amino acids, which regulate skin pH and moisture fluctuations. Amino acids also make up 40% of the natural moisture factor (NMF), which is an important substance for maintaining moisture in the stratum corneum.

There are various types of amino acids, and amino acids that can be used in the present invention are not limited thereto, but lysine, histidine, arginine, aspartic acid, threonine, serine, glutamic acid, proline, glycine, alanine, valine, methionine, iso Preference is given to at least one selected from the group consisting of leucine, leucine, tyrosine, phenylalanine, half cysteine, cysteine, asparagine, glutamine, and tryptophan.

In the present invention, the content of the amino acid is preferably 0.01 to 10 parts by weight based on 100 parts by weight of the total composition. If the content is less than 0.01 parts by weight, the effect of using an amino acid is not obtained, and if it exceeds 10 parts by weight, the feeling and stability is lowered, it is difficult to apply to various types of formulations.

The present invention also relates to a skin moisturizing cosmetic comprising the composition.

As described above, the composition for adjusting the pH of the skin activates the lipid hydrolase, inhibits the growth of harmful bacteria on the skin surface, and protects the skin barrier function. Accordingly, cosmetics containing the composition can increase the elasticity, flexibility and moisturizing of the skin.

Cosmetics for skin moisturizing according to the present invention can be prepared by a manufacturing method generally used in the cosmetic field, using the composition for adjusting the pH of the skin as an active ingredient, the method is not particularly limited.

The content of the pH adjusting composition of the skin is preferably 0.02 to 30 parts by weight based on 100 parts by weight of cosmetics. If the content is less than 0.02 parts by weight, it may be difficult to expect the effect of substantial moisture and elasticity increase and decrease in irritation in cosmetics, and if the content exceeds 30 parts by weight, the pH may be excessively lowered to cause irritation to the skin. And lowered stability, making it difficult to apply various formulations.

However, the content can be appropriately adjusted according to the content of the formulation or cosmetic additives.

The cosmetics may be provided in formulations such as basic cosmetics, makeup cosmetics, body cosmetics, hair cosmetics and scalp cosmetics. Formulations of the basic cosmetics include cream, essence, lotion, pack, nutrition cream, massage cream, cleansing cream, cleansing foam, cleansing water, cleansing oil, milky lotion, etc. Formulations of body cosmetics, soap, liquid detergent, Baths, sunscreen creams, sun oils, etc. For hair cosmetics, shampoos, conditioners, hair treatments, hair mousses, hair liquids, pomades, hair colorants, hair bleaches, and color rinses. Cosmetic formulations include hair tonic and scalp treatments.

Cosmetics of the present invention can also be appropriately added to the additives commonly used in the cosmetic field depending on the application. General additives in the cosmetic field include at least one selected from the group consisting of perfumes, pigments, fungicides, antioxidants, preservatives, humectants, thickeners, inorganic salts, synthetic polymers, oils, water, surfactants, low humidity alcohols, and chelating agents. Can be.

Hereinafter, the present invention will be described in more detail with reference to Examples and Comparative Examples. However, the scope of the present invention is not limited by the following examples.

One. Example  And Comparative example

To the cosmetic composition of the shower gel formulation of Examples 1 to 4 and Comparative Examples 1 to 5 in which the contents and ingredients shown in Table 1 were stirred in a mixer, and the composition materials were uniformly mixed through a process such as heating and cooling. .

Raw material name Example Comparative example One 2 3 4 One 2 3 4 5 Sodium Laurate Sulfate (28%) 30 30 30 30 30 30 30 30 30 Cocamidopropyl Betaine (30%) 10 10 10 10 10 10 10 10 10 Cocamidodiethanolamide 2 2 2 2 2 2 2 2 2 glycerin 2 2 2 2 2 2 2 2 2 Spices Quantity Quantity Quantity Quantity Quantity Quantity Quantity Quantity Quantity antiseptic Quantity Quantity Quantity Quantity Quantity Quantity Quantity Quantity Quantity Lactic acid 0.1 0.15 - 0.15 - 0.3 - - 0.005 Lysine 0.1 0.15 0.15 - - - 0.3 - 0.005 PCA 0.1 - 0.15 0.15 - - - 0.3 0.005 Citric acid - - - - 0.1 - - - - Purified water pH 5.5 5.4 6.2 5.0 5.5 4.5 6.5 5.8 6.9

2. Experimental Example

1) Skin irritation evaluation (closed) Patch ) Experiment

In order to evaluate skin irritation properties of the cosmetics of Examples 1 to 4 and Comparative Examples 1 to 5, a patch test was performed on 50 healthy men and women.

Each sample of 1% solution was applied to the pin chamber by a predetermined amount (approximately 0.2 g), and attached to the subject's skin for 4 hours while preventing the loss of the sample using a filter paper of a suitable size. Was removed. After removing the pin chamber, the skin condition after 2 hours was evaluated by the two experts to evaluate the degree of stimulation and the stimulation response according to the criteria shown in Table 2 below, and calculated by Equation 1 below to obtain the results. Table 3 shows.

Stimulus Reaction Criteria 0 - No symptoms One +- Have only slight erythema reactions 2 + Clear erythema, edema but no blisters 3 ++ Clear erythema, edema, blisters 4 +++ If you have a cannon

[Equation 1]

sample Judgment result (the number of people) Skin irritation index ++ + +- - Example 1 0 0 One 24 0.04 Example 2 0 0 3 22 0.12 Example 3 0 0 4 21 0.16 Example 4 0 0 4 21 0.16 Comparative Example 1 0 2 3 20 0.28 Comparative Example 2 0 0 5 20 0.20 Comparative Example 3 0 One 4 20 0.24 Comparative Example 4 0 0 5 20 0.20 Comparative Example 5 0 One 4 20 0.24

Referring to Table 3, the cosmetics of Examples 1 to 4 according to the present invention showed a more stable skin irritation index than the cosmetics of Comparative Examples 1 to 5.

These results indicate that skin irritation decreased when two or more types were mixed than when lactic acid, amino acids, or PCA were used alone, and skin irritation was significantly reduced when three types were used simultaneously.

2) skin Moisturizing  evaluation

In order to evaluate and determine the skin moisturizing power of Examples and Comparative Examples, 30 adult women were subjected to the following experiment twice a day for 4 days every week. The equipment used was measured using a skin moisture content measuring device (skin sulfis hygrometer, skin surface hygrometer, model name: SKICON-200, manufactured by IBM Corporation, Japan), and the evaluation method was first compared with Examples 1 to 4 After moistening water from 1 to 5 inside the arm, 5 ml of each formulation was rubbed in the hand for 20 seconds to form a foam, and the resulting foam was rubbed 20 times for 20 seconds inside the arm. Rinse in running water for 60 seconds, press dry for 10 seconds with a towel, and after 2 minutes the instrument was measured. The test was conducted in a constant temperature and humidity room at 25 ° C. and a relative humidity of 50%. The greater the moisture retention, the better the moisture retention.

Measurement result Example Comparative example One 2 3 4 One 2 3 4 5 Moisture retention rate (%) 102 96 94 95 88 91 90 91 89

Referring to Table 4 above, when two or more kinds of lactic acid, amino acid, or PCA were used alone, the water retention rate was higher than that of the comparative example, and when the three types were used simultaneously, the water retention rate was the highest. there was.

3) Skin irritation, elasticity and moisturizing evaluation

In order to compare the degree of skin irritation, elasticity and moisturizing, the home user test was performed on the cosmetics of the shower gel formulations obtained in Examples 1 to 4 and Comparative Examples 1 to 5, and the results are shown in Table 5 below. It was. A 5 mL sample was used to shower 180 women (30 for each sample), and the average value was obtained by evaluating skin irritation, elasticity, and moisturizing power on a 5-point scale.

Example Comparative example Evaluation item One 2 3 4 One 2 3 4 5 Skin irritation 1.2 2.0 2.2 2.1 2.9 2.4 2.6 2.5 2.7 Skin elasticity satisfaction 3.9 3.1 2.9 2.8 2.3 2.6 2.5 2.5 2.4 Skin Moisturizing Satisfaction 3.8 2.9 2.9 2.8 2.4 2.5 2.4 2.5 2.5

Referring to Table 5 above, skin irritation was reduced even when using two or more types of mixed lactate, amino acid, or PCA alone, even in the results of home childcare. It became. This tended to be similar to the closed patch test. In addition, when comparing skin elasticity and moisturizing satisfaction of Examples 1 to 4 and Comparative Examples 1 to 5, it can be seen that the Example shows better elasticity and moisturizing feeling than the Comparative Example, lactic acid, amino acid and PCA 3 When mixed species it was found that the elasticity and moisturizing feeling is more excellent.

Through the respective compositions and contents shown below, cosmetics of various formulations were prepared.

a) lotion

Raw material name (Unit: parts by weight) Glycerin 1,3-butylene glycol PEG 1500 allantoin DL-panthenol EDTA-2Na benzophenone-9 sodium hyaluronate ethanol octicododesses-16 polysorbate 20 preservative flavor pigment 6.0 30 1.0 0.1 0.3 0.02 0.04 5 10 0.2 0.2 Proper quantity Proper quantity Lactic Acid Amino Acids PCA 0.1 0.1 0.1 Adjust the total weight to 100 by the amount of purified water remaining

b) essence

Raw material name (Unit: parts by weight) Glycerin Betaine PEG 1500 Allatoin DL-Pantenol EDTA-2Na Benzophenone-9 Hydroxyethylcellulose Sodium Hyaluronate Carboxyvinyl Polymer Triethanolamine Octyldodetanol Octyldodeces-16 Ethanol Preservative Flavoring Pigment 10 5 2 0.1 0.3 0.02 0.04 0.1 8 0.2 0.18 0.3 0.4 6 Proper quantity Proper quantity Lactic Acid Amino Acids PCA 0.1 0.1 0.1 Adjust the total weight to 100 by the amount of purified water remaining

c) cream

Raw material name (Unit: parts by weight) Cetostearyl alcohol self-emulsifying monostearic acid lipophilic monostearic acid beeswax liquid paraffin squalane isocetyloctanoate tablets jojoba oil dimethylsiloxane monostearate sorbitan monostearic acid polyethyleneglycol glycerin propylene glycol betaine xanthan gum triethanolamine preservative 3.0 1.5 1.5 0.5 6.0 8.0 4.0 4.0 0.3 1.0 1.2 8.0 4.0 4.0 0.06 0.1 0.25 Proper quantity Lactic Acid Amino Acids PCA 0.1 0.1 0.1 Adjust the total weight to 100 by the amount of purified water remaining

d) gel

Raw material name (Unit: parts by weight) Glycerin Propylene Glycol Ethanol Polyoxyethylene Cured Castor Oil Carboxypolymer Triethanolamine Preservatives Flavoring Dyes 5.0 5.0 10.0 0.2 0.3 0.3 appropriate quantity appropriate quantity Lactic Acid Amino Acids PCA 0.1 0.1 0.1 Adjust the total weight to 100 by the amount of purified water remaining

Claims (11)

Lactic acid or salts thereof; Pyrrolidone carboxylic acid or a salt thereof; And Composition for pH adjustment of skin comprising two or more components selected from the group consisting of amino acids. The method of claim 1, Lactate salt is sodium lactate, copper lactate, aluminum lactate, magnesium lactate, and calcium lactate composition, characterized in that at least one selected from the group consisting of calcium lactate. The method of claim 1, The lactic acid or its salt content is 0.01 to 10 parts by weight based on 100 parts by weight of the total composition of the composition for adjusting the pH of the skin. The method of claim 1, The pyrididone carboxylate salt is at least one selected from the group consisting of sodium pyrididone carboxylate, potassium pyrididone carboxylate, pyrididone carboxylic acid copper, pyrididone carboxylate, aluminum pyrididone carboxylate, and zinc pyrididone carboxylate. A composition for adjusting the pH of skin. The method of claim 1, The content of pyrrolidone carboxylic acid or its salt is 0.01 to 10 parts by weight based on 100 parts by weight of the total composition of the composition for adjusting the pH of the skin. The method of claim 1, Amino acids consist of lysine, histidine, arginine, aspartic acid, threonine, serine, glutamic acid, proline, glycine, alanine, valine, methionine, isoleucine, leucine, tyrosine, phenylalanine, harpcysteine, cysteine, asparagine, glutamine, and tryptophan Composition for adjusting the pH of the skin, characterized in that at least one selected from. The method of claim 1, The content of the amino acid is a pH adjusting composition of the skin, characterized in that 0.01 to 10 parts by weight with respect to 100 parts by weight of the total composition. A skin moisturizing cosmetic comprising the composition of any one of claims 1 to 7. The method of claim 8, The skin pH control composition is a skin moisturizing cosmetic, characterized in that 0.02 to 30 parts by weight based on 100 parts by weight of cosmetics. The method of claim 8, Cosmetics include essences, lotions, creams, lotions, packs, nourishing creams, massage creams, cleansing creams, cleansing foams, cleansing water, cleansing oils, latex, soaps, liquid cleansers, baths, sunscreen creams, sun oils, shampoos, rinses, Cosmetics for skin moisturizing, characterized in that the formulation of the hair treatment, hair mousse, hair liquid, pomade, hair colorant, hair bleach, color rinse, hair tonic or scalp treatment. The method of claim 8, Cosmetics further comprise one or more additives selected from the group consisting of perfumes, pigments, fungicides, antioxidants, preservatives, humectants, thickeners, inorganic salts, synthetic polymers, oils, water, surfactants, low humidity alcohols, and chelating agents. Cosmetics for skin moisturizing, characterized in that.