CN110623899A - Rice-derived skin care composition and preparation method thereof - Google Patents
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Abstract
The invention relates to a rice-derived skin care composition and a preparation method thereof, and the rice-derived skin care composition is characterized by comprising, by mass, 10% of ~ 30% of an effect active substance, 1.0% of ~ 3.0.0% of lecithin, 0.5% of ~ 1.5.5% of rice furfuryl sterol, 2.5% of ~ 6.0.0% of lactobacillus/rice fermentation product, 0.5% of ~ 1.0.0% of rice amino acids, and the balance of a rice germ extract, wherein the effect active substance comprises rice germ oil, oryzanol and rice ceramide according to a mass ratio of 3 ~ 5: 2 ~ 3: 1.
Description
Technical Field
The invention relates to the field of daily necessities, in particular to a rice-derived skin care composition and a preparation method thereof.
Background
Infant skin is much different from adult skin in that 1) it is thin and soft, infant skin is only one tenth as thick as adult skin, and slight rubbing can cause damage and cause inflammation.2) there is little sebum, infant post-natal sebaceous gland activity is low, sebum secretion is low, skin surface protection is weak, moisture is more easily lost.3) skin contains more moisture and loses much moisture.too quickly, moisture in infant skin stratum corneum is one of the important causes of temporary imperfections in infant skin barrier, substances applied to infant skin may be more easily absorbed by the epidermis, and the chance of irritation or allergic reaction is higher.4) skin pH is more neutral.
In summary, the first principle of infant skin care is high safety, and skin care products developed for such people should comprehensively consider skin characteristics and care needs on the premise of ensuring safety, and give consideration to high protection and high stability. At present, the commercially available infant skin care products still have a plurality of problems, in order to reduce the factors which can cause irritation as much as possible, a simplified formula is pursued, only a small amount of moisturizing ingredients with the skin moistening effect are added, and other care requirements are ignored: strengthening skin barrier, keeping moisture, relieving, and resisting inflammation. Meanwhile, most of the added moisture retention components are substances from chemical synthesis sources such as polyhydric alcohols, and certain potential safety hazards exist. Therefore, the development of a skin care composition of natural origin and having multiple skin care effects is urgent.
Rice is a main food in daily life, contains a plurality of components beneficial to skin health, such as amino acids, glycosphingolipids, oryzanol, ferulic acid, vitamin E, rice germ oil and the like, and has proven skin care effects of moistening and preserving moisture, repairing skin barriers, resisting oxidation, resisting inflammation, relieving and the like. The functional components are natural in source, mild, non-irritant, high in skin-friendly property and wide in application prospect in skin care products.
Disclosure of Invention
The invention aims to solve the technical problem of providing a rice-derived skin care composition and a preparation method thereof, wherein the obtained composition is prepared from rice-derived raw materials, is mild and safe, has multiple skin care effects of strengthening and toughening a skin barrier, moisturizing, relieving, resisting inflammation and the like, and can effectively improve the skin problem of infants.
In order to solve the technical problems, the invention adopts the following technical scheme that the rice-derived skin care composition is characterized by comprising, by mass, ~ 30% of efficacy active substances, 1.0% of ~ 3.0.0% of lecithin, 0.5% of ~ 1.5.5% of rice furfuryl sterol, 2.5% of ~ 6.0.0% of lactobacillus/rice fermentation products, 0.5% of ~ 1.0.0% of rice amino acids and the balance of a rice germ extract, wherein the efficacy active substances comprise rice germ oil, oryzanol and rice ceramide according to the mass ratio of 3 ~ 5: 2 ~ 3: 1.
The invention also provides a preparation method of the rice-derived skin care composition, which is characterized by comprising the following steps of:
A. weighing 10% of ~ 30% of efficacy active substance, 1.0% of ~ 3.0.0% of lecithin, 0.5% of ~ 1.5.5% of rice furfuryl sterol, 2.5% of ~ 6.0.0% of lactobacillus/rice fermentation product, 0.5% of ~ 1.0.0% of rice amino acid and the balance of rice germ extract according to the mass percentage, wherein the efficacy active substance is composed of rice germ oil, oryzanol and rice ceramide according to the mass ratio of 3 ~ 5: 2 ~ 3: 1;
B. mixing the lecithin and the rice chaff sterol weighed in the step A with the efficacy active substances, and mixing at 70 ~ 85oC, stirring at the rotating speed of 600 ~ 800 rpm until the mixture is completely dissolved to obtain an oil phase;
C. mixing the rice germ extract, rice amino acids and lactobacillus/rice fermentation product obtained in step A at 70 ~ 85oC, stirring at the rotating speed of 600 ~ 800 rpm until the mixture is uniformly mixed to obtain a water phase;
D. pouring the water phase obtained in the step C into the oil phase obtained in the step B, shearing by using a high-speed shearing machine at the rotation speed of 10000 rpm for 3 ~ 5 min to obtain crude milk, and homogenizing by using a high-pressure homogenizer at the pressure of 32 ~ 65 MPa for 3 ~ 5 times to obtain the rice-derived skin care composition.
The particle size analysis of the samples was performed using an Anto Paar Antopar Litesizer 500 laser particle size Analyzer, with the skin care compositions described in examples 1-4 having an average particle size in the range of 100-300 nm.
The lecithin (INCI name: lecithin, number of used cosmetic raw material name catalog (2015 edition): 04456) is derived from rice germ or other plants, is safe and mild, and is a structural component for forming nanoemulsion.
The rice germ extract (INCI name: Rice (Oryza SATIVA) germ extract, number: 01881 in catalogue of used cosmetic raw materials 2015 edition) of the invention is a water-soluble extract of fresh rice germ after degreasing treatment, and is rich in B vitamins, such as B vitamins3、B5、B6、B12And the like, and the skin care cream also contains gamma-aminobutyric acid, and has multiple skin care effects of relieving, moisturizing, brightening the skin and the like.
The rice amino acids (INCI: rice amino acids, number 01890 in the catalogue of names of used cosmetic raw materials (2015 edition)) comprise more than ten amino acids such as threonine, serine, glutamic acid, proline, glycine, alanine, valine, histidine, arginine and the like, the amino acids are natural moisturizing factors naturally existing in the skin cuticle, have excellent moisturizing efficacy, and the moisture retention of the skin can be effectively improved by supplementing natural amino acids.
The oryzanol (INCI name: oryzanol, number of used cosmetic raw material catalog (2015 edition): 02589) is also called rice bran extract, and is an important nutritional active factor of rice bran, rice bran oil and rice germ. Oryzanol is a natural substance and has high safety, and researches show that when the toxicity tests of subacute, chronic and the like of the oryzanol are carried out on mice and rats, the oral LD50 value is more than 25g/kg, no abnormal phenomenon exists in the test process, and the antigenicity and mutagen tests carried out on the oryzanol also show no abnormality. Oryzanol has effects of resisting lipid peroxidation, inhibiting expression of inflammatory factor, further inhibiting inflammation, and effectively preventing pigmentation caused by inflammation.
The rice germ oil (INCI name: rice (ORYZA SATIVA) germ oil, wherein the index of the names of used cosmetic raw materials (2015 edition) is No. 01882), contains natural nutrient vitamin E, has excellent antioxidant and skin moistening effects, is rich in Omega 6 linoleic acid, and can participate in synthesis of ceramide in skin after being absorbed by the skin to promote repair of damaged skin barriers.
The rice ceramide (INCI: glycosphingolipids, number of the used cosmetic raw material catalog (2015 edition): 06600) is extracted from rice bran and rice germs, is natural in origin, contains rich glycosphingolipids, can supplement the ceramide missing in the skin, simultaneously effectively promotes the synthesis of the ceramide, reforms the horny layer with lipid disorder, strengthens the skin barrier, enhances the capacity of the skin to resist external stimulation, and strengthens the water retention of the skin.
The rice fermentation product (INCI: Lactobacillus/Rice fermentation product, number 2015:05658) is obtained by fermenting rice, the ratio of amylopectin to amylopectin is changed, the amylopectin content in the fermented rice is increased, the amylopectin forms a spiral structure in a water-oil mixing system, the interior is oleophilic, and the emulsification effect is realized by adsorbing a large amount of oil.
Based on the characteristics of skin of infants, various raw materials which are all from rice are selected according to skin care requirements of the infants, and a high-energy emulsification method is adopted to prepare the skin care composition which can simultaneously load three oil-soluble skin care ingredients, namely rice germ oil, oryzanol and rice ceramide, and has the beneficial effects of 1) natural sources, safety and mildness, 2) multiple skin care effects of strengthening and toughening skin barrier, moisturizing, relieving, resisting inflammation and the like, and 3) the obtained skin care composition is nanoemulsion, has the average particle size of 100 ~ 300 nm, is easy to absorb by skin, and has good stability.
To demonstrate that the skin care compositions of the present invention are safe and mild, the following tests were performed:
1. multiple dosing skin irritation test
The 8 healthy rabbits were randomly divided into 2 groups, 4 in each of the intact skin group and the damaged skin group, and the stimulation study was performed by a left-right comparison method. Before the experiment, the white rabbits were depilated symmetrically on both sides of the spine with an electric razor, the depilated area was 3 cm × 3 cm for two left and right blocks, and after 24 h of depilating, the skin was examined for the presence of damage and the occurrence of erythema or eschar, and the white rabbits with damage or skin abnormality could not be used for the irritation experiment of the intact skin group. The damaged skin group was subjected to a # -shaped skin incision with a sterilized scalpel, and the subcutaneous tissue was not damaged until slight bleeding occurred. One side of the hair removal area is divided into an administration area and a control area, 0.3 g of the skin care composition described in the embodiment 2 is smeared on the hair removal part of the test area on the left side of the spine, 0.1 ml of physiological saline is smeared on the control area on the right side of the spine for 1 time every day and is smeared for 7 days continuously, the appearance of the smearing part of the experimental rabbit is observed and recorded at 1 h, 24 h, 48 h and 72 h after the last administration, and irritation grading is carried out.
Referring to the guidance principle of the State food and drug administration on new drug toxicology, the skin change phenomenon of each experimental animal at each time point in the observation period is recorded, the mean stimulation score of each animal is calculated, the skin irritation experimental evaluation is carried out according to the stimulation intensity evaluation standard, the mean score = (erythema + edema)/animal number, the skin irritation response and the stimulation intensity evaluation standard are referred to tables 1 and 2, and the experimental results are shown in tables 3 and 4.
TABLE 1 skin irritation response Scoring criteria
TABLE 2 evaluation criteria for skin irritation intensity
Table 3 complete skin group score results after multiple dosing (n = 4)
Table 4 score results for the damaged skin groups after multiple dosing (n = 4)
From the experimental results, it can be seen that the skin care composition of example 1 of the present invention has no irritation to both intact skin and damaged skin of rabbits. The skin care composition provided by the invention is free from irritation to the skin, safe and mild.
2. Patch test on human skin
Selecting 30 volunteers of 18 ~ 60 years old meeting the test requirements as subjects, and selecting the volunteers with the area of no more than 50 mm2And (3) qualified spot test device with the depth of about 1 mm, respectively putting 0.02 ml of the skin care composition described in example 1 ~ 5 into a small chamber of a spot test device, wherein a control hole is a blank control, applying the spot test device added with the test object to the back of the test object by using a hypoallergenic adhesive tape, lightly pressing the spot test device with a palm to uniformly apply the spot test device to the skin, keeping the application for 24 h, respectively observing the skin reaction according to the standard of table 5 after 30 min (after the indentation disappears), 24 h and 48 h after the spot test device of the test object is removed, and recording the observation result.
TABLE 5 skin closed Patch test skin response grading Standard
The result of the skin patch test of the human body shows that 30 subjects observe skin reactions in 30 min, 24 h and 48 h through the skin patch test of the skin care composition (example 1 ~ 4), and the number of the adverse skin reactions is 0, which indicates that the skin care composition is safe to use.
To demonstrate the anti-inflammatory efficacy of the skin care compositions of the present invention, the following experiments were performed:
cryopreserving human epidermal immortalized cells (Hacat cells) from-80oC after taking out of the refrigerator, quickly 37oC, water bath, slightly shaking for 1-2 min to completely melt the mixture for 1000 r/min, centrifuging for 10 min, discarding the supernatant, adding 1 mL of cell culture solution, and transferring to 10 cm2In a culture flaskIs arranged at 37oC 5%CO2Culturing in the environment. When the cells grew to 90% confluence, the cells were gently washed twice with 2 mL of phosphate buffer (pH 7.4). Adding 200 μ L of 0.25% pancreatin, adding CO2Digesting in incubator for 5 min, observing to confirm that cells have fallen off from the wall of culture flask, adding 2 mL of complete culture medium to terminate digestion, centrifuging at 800 r/min for 0min, removing supernatant, adding 4 mL of culture medium, counting, and counting at 5 × 105Inoculating at density of 10 cm2A culture flask. Digesting the cells at 2X 106Density per well cells were seeded in 6-well plates and cells were treated with 30% (w/w) of the nanoemulsion aqueous solution described in example 1 for 30 min, 60 min, 90 min and 120 min, respectively. Total cellular RNA was extracted and the effect of treatment of the sample to be tested on the expression of inflammatory cytokines at the transcriptional level was analyzed by fluorescence quantification, the results of which are shown in Table 6.
TABLE 6 Effect of the skin care compositions of example 1 on the amount of 1L-1 alpha and 1L-6 expressed
As can be seen from Table 6, the skin care compositions of the present invention have anti-inflammatory effects, as demonstrated by the decreased expression of inflammatory factors 1L-1 α and 1L-6 following treatment of Hacat cells with 30% (w/w) of the skin care composition described in example 1.
To prove that the skin care composition has the effects of restoring the barrier function of the skin and moisturizing, the following experiments are carried out:
selecting at least 30 healthy volunteers according to evaluation guideline of moisturizing efficacy of cosmetic, wherein the test instruments are Tewameter TM 300 and Corneometer CM 825 of CK company in Germany, and the test site ensures constant temperature and humidity, and the temperature is 20 ~ 22oC, relative humidity 40 ~ 60%, the test subject needs to wash the inner side of forearm with specified face cleaning cream, after cleaning, making measurement area marks on the inner side of forearm, each test area is at least 3 cm x 3 cm., before testing, sitting still in a constant temperature and humidity room for at least 20 min, exposing forearm, avoiding touch, and subjecting the specified area of inner side of left and right arm of the test subject to epidermis water loss (TEWL value) and waterThe content was measured and recorded. The initial values (t = 0) of the test areas were measured, and then the nanoemulsion described in example 1 was randomly and uniformly applied to the test areas with a latex finger cot, with a single application weight of 2 mg/cm2. TEWL values and moisture content of the painted area (test group) and the blank area (blank group) were measured at 2 hours, 4 hours, and 8 hours after the samples were used, respectively. The test is done by the same measuring staff. The test group used the skin care composition described in example 1, and the blank control group did not apply any product, and the results are shown in tables 7 and 8.
TABLE 7 variation of the skin TEWL values over time
TABLE 8 variation of skin moisture content with time
As can be seen from table 7, the difference in TEWL in the test area was significantly different (P < 0.05) after 2, 4, 8 hours using the skin care composition described in example 1, while there was no significant difference in the control group (P > 0.05), indicating that the nanoemulsion of the present invention has the efficacy of restoring the skin barrier function. As can be seen from table 8, after 2, 4 and 8 hours using the nanoemulsion of the present invention, the tested area showed significant difference in the moisture content of the stratum corneum (P < 0.05), while the control group showed no significant difference (P > 0.05), indicating that the skin care composition of the present invention has moisturizing effect.
Eczema is a common skin disease characterized by erythema, desquamation, papules, lichenification, exfoliation and itching, which can be suffered by both children and adults and is associated with a defect in the skin barrier function. To demonstrate that the skin care composition of the present invention has efficacy in alleviating symptoms of eczema, the following experiments were performed:
30 patients with mild to moderate eczema were recruited, aged 5 ~ 40 years, the subjects were randomized into 2 groups of 15 subjects per group, and during the trial period, the subjects in the trial group were applied with a cream containing 10% of the skin care composition described in example 1 to the affected area before and after cleaning every day, and the subjects in the control group were applied with the same base without the skin care composition described in example 1.
TABLE 9 changes in eczema
As can be seen from table 9, the skin care composition of the present invention has an effect of improving eczema symptoms (P < 0.05), on one hand, it can prevent excessive loss of moisture in the skin by improving damaged skin barrier, achieve effective relief of dryness and generation of scales, and reduce itching symptoms caused by dryness; meanwhile, the ointment has the anti-inflammatory effect, and can control and intervene the inflammation degree of an affected part, thereby playing a role in improving eczema.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below.
Example 1 a method of preparing a rice-derived skin care composition, characterized by the steps of:
A. weighing 10% of efficacy active substance, 1.0% of lecithin, 0.75% of rice furfuryl sterol, 2.5% of lactobacillus/rice fermentation product, 1.0% of rice amino acid and the balance of rice germ extract according to the mass percentage; the functional composition is a mixture consisting of rice germ oil, oryzanol and rice ceramide in a mass ratio of 4: 2: 1;
B. mixing the lecithin and the rice chaff sterol weighed in the step A with the efficacy composition, maintaining stirring at 650 rpm, and heating to 80 DEG C oCUntil the mixture is fully dissolved and uniformly mixed, obtaining an oil phase;
C. extracting the rice germs weighed in the step AMixing the extract, rice amino acids and lactobacillus/rice fermentation product, maintaining stirring at 650 rpm, and heating to 72%oC, uniformly mixing to obtain a water phase;
D. and D, pouring the water phase obtained in the step C into the oil phase obtained in the step B, shearing for 3 min at the speed of 10000 rpm by using a high-speed shearing machine to prepare coarse milk, and homogenizing for 4 times at the pressure of 38MPa by using a high-pressure homogenizer to obtain the skin-care composition.
Example 2 a method of preparing a rice-derived skin care composition, characterized by the steps of:
A. weighing 15% of efficacy active substance, 1.5% of lecithin, 0.5% of rice furfuryl sterol, 3.8% of lactobacillus/rice fermentation product, 0.8% of rice amino acid and the balance of rice germ extract according to the mass percentage; the functional composition is a mixture consisting of rice germ oil, oryzanol and rice ceramide in a mass ratio of 3: 1;
B. mixing the lecithin and the rice chaff sterol weighed in the step A with the efficacy composition, maintaining stirring at 700 rpm, and heating to 70 DEG C oCUntil the mixture is fully dissolved and uniformly mixed, obtaining an oil phase;
C. mixing the rice germ extract, rice amino acids and lactobacillus/rice fermentation product weighed in step A, stirring at 750 rpm, and heating to 74%oC, uniformly mixing to obtain a water phase;
D. and D, pouring the water phase obtained in the step C into the oil phase obtained in the step B, shearing for 4 min at the speed of 10000 rpm by using a high-speed shearing machine to prepare coarse milk, and homogenizing for 3 times at the pressure of 50 MPa by using a high-pressure homogenizer to obtain the skin-care composition.
Example 3 a method of preparing a rice-derived skin care composition, characterized by the steps of:
A. weighing 25% of efficacy active substance, 2.5% of lecithin, 1.0% of rice furfuryl sterol, 4.6% of lactobacillus/rice fermentation product, 0.5% of rice amino acid and the balance of rice germ extract according to the mass percentage; the functional composition is a mixture consisting of rice germ oil, oryzanol and rice ceramide in a mass ratio of 5: 2: 1;
B. mixing the lecithin and the rice chaff sterol weighed in the step A with the efficacy composition, maintaining stirring at 750 rpm, and heating to 78% oCUntil the mixture is fully dissolved and uniformly mixed, obtaining an oil phase;
C. mixing the rice germ extract, rice amino acids and lactobacillus/rice fermentation product weighed in step A, stirring at 700 rpm, and heating to 78 deg.CoC, uniformly mixing to obtain a water phase;
D. and D, pouring the water phase obtained in the step C into the oil phase obtained in the step B, shearing for 5 min at the speed of 10000 rpm by using a high-speed shearing machine to prepare coarse milk, and homogenizing for 3 times by using a high-pressure homogenizer at the pressure of 65 MPa to obtain the skin care composition.
Example 4 a method of preparing a rice-derived skin care composition, characterized by the steps of:
A. weighing 30% of efficacy active substance, 3.0% of lecithin, 1.5% of rice furfuryl sterol, 6.0% of lactobacillus/rice fermentation product, 0.65% of rice amino acid and the balance of rice germ extract according to the mass percentage; the functional composition is a mixture consisting of rice germ oil, oryzanol and rice ceramide in a mass ratio of 5: 3: 1;
B. mixing the lecithin and the rice chaff sterol weighed in the step A with the efficacy composition, maintaining stirring at 800 rpm, and heating to 85% oCUntil the mixture is fully dissolved and uniformly mixed, obtaining an oil phase;
C. mixing the rice germ extract, rice amino acids and lactobacillus/rice fermentation product weighed in step A, stirring at 800 rpm, and heating to 70%oC, uniformly mixing to obtain a water phase;
D. and D, pouring the water phase obtained in the step C into the oil phase obtained in the step B, shearing for 4 min at the speed of 10000 rpm by using a high-speed shearing machine to prepare coarse milk, and homogenizing for 5 times by using a high-pressure homogenizer at the pressure of 46 MPa to obtain the skin-care composition.
Claims (2)
1. A rice-derived skin care composition is characterized in that the rice-derived skin care composition is prepared from, by mass, 10% ~ 30% of an efficacy active substance, 1.0% ~ 3.0.0% of lecithin, 0.5% ~ 1.5.5% of rice furfuryl sterol, 2.5% ~ 6.0.0% of lactobacillus/rice fermentation product, 0.5% ~ 1.0.0% of rice amino acids and the balance of a rice germ extract, wherein the efficacy active substance is composed of rice germ oil, oryzanol and rice ceramide according to a mass ratio of 3 ~ 5 to 2 ~ 3 to 1.
2. A method for preparing a rice-derived skin care composition, characterized by comprising the steps of:
A. weighing 10% of ~ 30% of efficacy active substances, 1.0% of ~ 3.0.0% of lecithin, 0.5% of ~ 1.5.5% of rice furfuryl sterol, 2.5% of ~ 6.0.0% of lactobacillus/rice fermentation products, 0.5% of ~ 1.0.0% of rice amino acids and the balance of rice germ extract according to the following mass percentage, wherein the efficacy composition is a mixture consisting of rice germ oil, oryzanol and rice ceramide in a mass ratio of 3 ~ 5: 2 ~ 3: 1;
B. mixing the lecithin and the rice chaff sterol weighed in the step A with the efficacy composition, maintaining stirring at 600 ~ 800 rpm, and heating to 70 ~ 85oC, fully dissolving the mixture and uniformly mixing to obtain an oil phase;
C. mixing the rice germ extract, rice amino acids and lactobacillus/rice fermentation product weighed in step A, stirring at 600 ~ 800 rpm, and heating to 70 ~ 78oC, uniformly mixing to obtain a water phase;
D. and D, pouring the water phase obtained in the step C into the oil phase obtained in the step B, shearing the oil phase for 3 ~ 5 min at the speed of 10000 rpm by using a high-speed shearing machine to prepare coarse milk, and homogenizing the coarse milk for 3 ~ 5 times by using a high-pressure homogenizer at the pressure of 32 ~ 65 MPa to obtain the rice-derived skin-care composition.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112190520A (en) * | 2020-11-09 | 2021-01-08 | 深圳市长久科技发展有限公司 | Essence with anti-aging effect and preparation method thereof |
| CN112618665A (en) * | 2020-12-19 | 2021-04-09 | 杭州益品新五丰药业有限公司 | Furfuryl sterol-oryzanol combined medicinal preparation for improving immune response |
| CN113842353A (en) * | 2021-11-18 | 2021-12-28 | 瑞昌市瑞美化妆品有限公司 | Lipstick with velvet texture and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101146508A (en) * | 2005-02-11 | 2008-03-19 | 通用名制药公司 | Cosmetic and cosmeceutical compositions for restoration of skin barrier function |
| CN103751065A (en) * | 2014-02-11 | 2014-04-30 | 周县萍 | Whitening lotion for pregnant women and preparation method thereof |
| CN104586735A (en) * | 2014-12-09 | 2015-05-06 | 美嘉乐(上海)生物科技有限公司 | Method for preparing fermented product filtrate by fermenting rice with lactobacillus casei, and application of fermented product filtrate |
| CN110115691A (en) * | 2019-05-29 | 2019-08-13 | 湖南美媛本草生物工程有限公司 | A kind of whitening and softening skin lotion of the product containing rice fermentation and preparation method thereof |
-
2019
- 2019-11-04 CN CN201911068019.9A patent/CN110623899A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101146508A (en) * | 2005-02-11 | 2008-03-19 | 通用名制药公司 | Cosmetic and cosmeceutical compositions for restoration of skin barrier function |
| CN103751065A (en) * | 2014-02-11 | 2014-04-30 | 周县萍 | Whitening lotion for pregnant women and preparation method thereof |
| CN104586735A (en) * | 2014-12-09 | 2015-05-06 | 美嘉乐(上海)生物科技有限公司 | Method for preparing fermented product filtrate by fermenting rice with lactobacillus casei, and application of fermented product filtrate |
| CN110115691A (en) * | 2019-05-29 | 2019-08-13 | 湖南美媛本草生物工程有限公司 | A kind of whitening and softening skin lotion of the product containing rice fermentation and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 多多: "藏元美人怎么样 附藏元美人最全测评及官网", 《HTTPS://WWW.CHINABRANDS.CN/DIANSHANG/ARTICLE-ZANGYUANMEIREN-2101.HTML》 * |
| 时光稻流的博客: "舌尖上的护肤佳品-大米", 《HTTP://BLOG.SINA.COM.CN/S/BLOG_161C785540102WMQZ.HTML》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112190520A (en) * | 2020-11-09 | 2021-01-08 | 深圳市长久科技发展有限公司 | Essence with anti-aging effect and preparation method thereof |
| CN112618665A (en) * | 2020-12-19 | 2021-04-09 | 杭州益品新五丰药业有限公司 | Furfuryl sterol-oryzanol combined medicinal preparation for improving immune response |
| CN113842353A (en) * | 2021-11-18 | 2021-12-28 | 瑞昌市瑞美化妆品有限公司 | Lipstick with velvet texture and preparation method thereof |
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