CN109431912A - Skin oil balancing composition and application thereof - Google Patents

Skin oil balancing composition and application thereof Download PDF

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Publication number
CN109431912A
CN109431912A CN201811609285.3A CN201811609285A CN109431912A CN 109431912 A CN109431912 A CN 109431912A CN 201811609285 A CN201811609285 A CN 201811609285A CN 109431912 A CN109431912 A CN 109431912A
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extract
oil
scalp
skin
hair
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CN109431912B (en
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戴跃锋
康文术
何广文
颜少慰
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Syoung Cosmetics Manufacturing Co Ltd
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Hunan Yujia Cosmetics Manufacturing Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/55—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/673—Vitamin B group
    • A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/008—Preparations for oily skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/006—Antidandruff preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/02—Preparations for cleaning the hair
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/12—Preparations containing hair conditioners
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/592—Mixtures of compounds complementing their respective functions
    • A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients
    • A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
    • A61K2800/782—Enzyme inhibitors; Enzyme antagonists

Abstract

The invention relates to a skin oil balancing composition and application thereof, wherein the skin oil balancing composition comprises nicotinamide, inositol, caprylyl glycine and an oil control plant extract; the oil control plant extract comprises California officinalis extract, Urtica dioica extract, Equisetum arvense extract, Rosemary extract, Melissa officinalis extract, horse chestnut seed extract, Salvia officinalis extract and coltsfoot extract. The skin oil balance composition can solve the problems of scalp oil generation, itching, alopecia and the like around the scalp, and can effectively improve the scalp problems by adopting nicotinamide, inositol, caprylyl glycine and oil control plant extract to maintain oil balance.

Description

Skin oil and fat balances composition and its application
Technical field
The present invention relates to shield product field is washed, composition and its application are balanced more particularly to a kind of skin oil and fat.
Background technique
The World Health Organization promulgate ten health standards in, Article 9 be exactly hair it is glossy, without dandruff.On scalp It is dispersed with many blood vessels, nerve, sebaceous glands, sweat gland and hair follicle, scalp health is related to health, so skin of head and face Portion's skin equally needs meticulous cleaning and care.By accumulating within more than 30 years and developing, China's hair washing market for water is come into The new period of competition and high speed development comprehensively, each producer are all constantly releasing new technology, new product, and the majority of consumers are not yet The disconnected hair-washing hair-care scalp care products for seeking to be suitble to oneself.In the sense that from now on hair washing product will gradually to wash shield Cosmetics development becomes people and promotes quality of the life, and perfect self-image enhances the powerful mean of charisma.Look forward to 21 generation It records, the consumption figure of Chinese hair cosmetic will be continuously increased, and market scale can constantly expand.According to statistics, the perfume (or spice) of current China Wave market is more than Japan already, close to the U.S., but with worthwhile also less than these developed countries per capita.From the angle of care product It sees, the hair conditioner market scale in the U.S. is about the half in shampoo market, and the hair conditioner market scale of Japan and its shampoo market It is close.But the actual conditions in Chinese hair products market are reviewed, scale is less than 1/10th of shampoo, this phenomenon one Aspect is because current economic condition includes that purchasing power also has certain limitations, and another aspect consumer takes care of hair consciousness also relatively not Foot.But in view of China's economy will continue to steadily increase from now on, demand of the people to hair-dressing and hair care care products will therewith Be continuously improved, it may be said that China wash shield cosmetics potential market it is very huge, development prospect is very wide.
In recent years, the demand with people to health and environmental protection is growing, and silicate-containing oil shampoo causes biggish strive View, reason is to be easy to remain on scalp, although research shows that hair more satin can be made suitable using silicate-containing oil shampoo Cunning is elegant, but silicate-containing oil shampoo is because its is waterproof, and when hair washing is difficult to clean up, and partially remains in scalp, on hair, for a long time Using that can cause to deposit on scalp, the problems such as band connections is itched, dandruff, hair are greasy, epilation and hair stimulate, and silicon Oil gathers on hair will cause hair thicker, hair wash it is dry after it is flat, collapse, be not fluffy.Silicone oil is that a kind of chemistry is lazy Property substance, be difficult to degrade under natural conditions, in production and use process, silicone oil enters environment with discharge of wastewater, causes environment dirty Dye.Although being only the addition for eliminating silicone oil on the market in the presence of the shampoo for much declaring no silicone oil, not for formula Other components are adjusted, this is substantially backwards to the shampoo epoch of no silicone oil addition, can not really solve to consume It is too strong without leading to degreasing can not to accomplish mild oil-control for the pain spot of person, so it is difficult to realize scalp water and oil balance.
Summary of the invention
Based on this, it is necessary to provide a kind of skin oil and fat balance composition of achievable scalp water and oil balance.
A kind of skin oil and fat balance composition, including niacinamide, inositol, capriloyl glycine and oil-control plant extracts； The oil-control plant extracts includes Europe medicine chrysanthemum extract, nettle extract, Horsetail P.E, Rosmarinus officinalis extract, lemon balm Extract, horse chestnut seed extract, Sage extract and coltsfoot extract.
In one of the embodiments, include following mass parts component: 1~5 part of niacinamide, 0.1~0.5 part of inositol, 0.1~1 part and 0.05~1 part of oil-control plant extracts of capriloyl glycine.
In one of the embodiments, include following mass parts component: 1~3 part of niacinamide, 0.1~0.3 part of inositol, 0.3~0.8 part and 0.3~0.6 part of oil-control plant extracts of capriloyl glycine.
In one of the embodiments, include the component of following mass parts: 2 parts of niacinamide, 0.2 part of inositol, caprylyl are sweet 0.5 part and 0.5 part of oil-control plant extracts of propylhomoserin.
In one of the embodiments, in the oil-control plant extracts, the Europe medicine chrysanthemum extract, nettle extract, Horsetail P.E, Rosmarinus officinalis extract, honeybee flower extract, horse chestnut seed extract, Sage extract and coltsfoot extract Mass ratio are as follows:
(0.1~1): (0.1~1): (0.1~1): (0.1~1): (0.1~1): (0.1~1): (0.1~1): (0.1~ 1)。
The oil-control plant extracts further includes following components in one of the embodiments: water, propylene glycol, ethyoxyl Diethylene glycol (DEG), glucose and lactic acid.
The present invention also provides a kind of above-mentioned skin oil and fat balance compositions to wash the application in shield product in preparation.
The shield product of washing are selected from shampoo, hair conditioner, hair oil or scalp care Essence in one of the embodiments,.
The present invention also provides one kind to wash shield product, including above-mentioned skin oil and fat balances composition.
It in one of the embodiments, further include following components: glycerol, propylene glycol, butanediol, oligomerization hyaluronic acid, urine Bursin and arginine.
Skin oil and fat balance composition of the invention has the advantages that
1) the problems such as above-mentioned skin oil and fat balance composition surrounds fuel-displaced scalp existing for scalp, itch, alopecia, using cigarette Amide, inositol, capriloyl glycine and oil-control plant composition (M82N) maintain grease balance, are effectively improved scalp problems.
2) present invention is had using capriloyl glycine inhibits 5α-reductase activity well, reduces its DHT in the scalp Content reduce the proliferation sebum basis of chlosma, effectively DHT inhibited to destroy to avoid the excessive secretion of scalp grease Hair follicle leads to alopecia.
3) present invention adjusts fat secretion using niacinamide, inositol and unique water soluble plant extract compound.It plants Object compound forms high-efficiency plant oil-control by Europe medicine chrysanthemum, nettle, meadow pine, rosemary, lemon balm, horse chestnut, Salvia japonica and coltsfoot Composition has effects that releive calm.
4) present invention uses grease balancing technique, and scalp fat content can effectively be inhibited to increase, and evaluates and tests through 3 hours, effectively Inhibiting scalp fat content to increase is 220.41%~281.9%, it was demonstrated that can effectively inhibit scalp fat secretion, can effectively subtract Few dandruff, seborrhea risk.
5) present invention uses water and oil balance mechanism, and when 90min can promote moisture content and be up to 62.3%~72.31%, 30.31%~40.32% is improved compared with control sample, it was demonstrated that can effectively promote scalp moisture levels.
Detailed description of the invention
Fig. 1 is the sebum secretion object content measuring knot after the Essence used respectively containing 10%M82N and without M82N Fruit；
Fig. 2 is the experimental result picture for inhibiting scalp fat content to increase of each control sample and example sample；
Fig. 3 is the experimental result picture of the promotion scalp moisture levels of each control sample and example sample.
Specific embodiment
To facilitate the understanding of the present invention, below will to invention is more fully described, and give it is of the invention compared with Good embodiment.But the invention can be realized in many different forms, however it is not limited to embodiment described herein.Phase Instead, purpose of providing these embodiments is makes the disclosure of the present invention more thorough and comprehensive.
Unless otherwise defined, all technical and scientific terms used herein and belong to technical field of the invention The normally understood meaning of technical staff is identical.Term as used herein in the specification of the present invention is intended merely to description tool The purpose of the embodiment of body, it is not intended that in the limitation present invention.Term as used herein "and/or" includes one or more phases Any and all combinations of the listed item of pass.
The skin oil and fat of one embodiment of the invention balances composition, including niacinamide, inositol, capriloyl glycine and oil-control Plant extracts.Wherein, oil-control plant extracts includes that Europe medicine chrysanthemum extract, nettle extract, Horsetail P.E, rosemary mention Take object, honeybee flower extract, horse chestnut seed extract and Sage extract.
Skin oil and fat balance composition of the invention is with mildly for theory, using scalp care as core, naturally for mesh Mark is mainly combination oil-control component, core with niacinamide, inositol, capriloyl glycine and oil-control plant extracts (M82N) Effect is the nursing of scalp water and oil balance, and can wash in shield product and apply in no silicone oil scalp.
1, scalp and hair
1.1 scalp structures and barrier
The soil that scalp is depended on for existence as hair, the balance of ecological environment are the basic of hair healthy growth.Scalp It is most thin one of the skin of human body, blood vessel rich in, it is body skin skin that the speed of aging, which is 6 times of facial skin, 12 times.Scalp area is about 650~700cm2, average follicle population is 200~250/cm2, about 52~79 on forehead A/cm2, about 42~78/cm on cheek2.The sebum amount of scalp surface secretion can reach 288 μ g/cm in 12h2, and forehead Sebum amount there was only 144 μ g/cm2。
The sweat gland of scalp, smegma are vigorous, but since the obstruction of hair is difficult to clean, it is rapid to easily cause microorganism Breeding, sebum is irradiated with ultraviolet radiation and the factors such as environmental pollution influence, and is easy to happen peroxidization, is caused scalp slight Inflammatory reaction, physics, chemical stimulation brought by certain Hair Stying Products etc. also easily cause scalp irritation.The self-control of scalp Ability also can gradually fail with the increase at age.These above-mentioned factors cause the reduction of scalp protective barrier, telogen Extend, scalp hair follicles become smaller, hair follicle capillary is reduced, melanin is formed reduces and scalp is damaged thinning, cause scalp oily The symptoms such as greasy, sensitive, dry, itch, alopecia, white hair and dandruff.
According to investigations the results show that 70% or more healthy men and women has scalp problems, erythema and inflammation in summer and winter 70% is accounted for, dandruff accounts for 30%, and scalp pimple accounts for 20%.In addition, 101 women to 20~59 years old carry out scalp health state tune Display is looked into, have rubescent scalp, dry, pimple and dandruff problem accounts for 66%.As it can be seen that the scalp of most of healthy populations is simultaneously It is non-for health status.
1.2 hair structures and component
The main component of hair is keratin (accounting for about 80% or more), it is made of hair shaft and two part of hair follicle.Hair shaft Hair cuticle, cortex, three layers of medullary substance can be divided into, hair cuticle is the outermost layer of hair shaft, surrounds hair shaft by 3~7 layers of hair cuticle cell, often The thickness of a hair cuticle cell is about 3 μm~5 μm.The structure of hair cuticle cell can be divided into epicuticle, exocuticle and endepidermis again, Wherein High-sulphur protein rich in epicuticle and exocuticle, can resist the influence of extraneous physics and chemical factor.Cortex is tight It is close around medullary substance, the diameter of cortex cell is about 2 μm~3 μm.Cortex cell is by many crude fibres, fine fibre and fibril Dimension composition, the diameter of fibrinogen is only 2 × 10-3μm, it is made of the keratin of 2~3 strands of alpha-helixes, then by many fibrinogen shapes It is 8 × 10 at diameter-3μm fine fibre, then constitute crude fibre by many fine fibres.These above-mentioned fibers are embedded in by height In the cellular matrix of sulfoprotein composition and fibre bundle closely is formed, wherein in keratin composition, low-sulfur albumen accounts for 60%, High-sulphur protein accounts for 40%.Contain pigment granule in the matrix of cortex cell, the number of pigment granule decides the color of hair.Marrow Matter is located at the center of hair shaft, is made of 2~3 layers of polygonal keratinocyte, in addition to the keratin structure of medullary epithelium is beta sheet, The keratin structure of hair cuticle and cortex cell is alpha-helix.
Recent study discovery has one layer of non-polar lipid covering outer in addition to hair, internal lipids is also contained in hair, it It is predominantly located in the space between cells between hair cuticle cell and between hair cuticle and cortex cell.The internal lipids are known as cell Complex compound, the lipid profile of abbreviation CMC, CMC account for the 57% of entire hair shaft fiber, are the primary structure lipids of hair, account for hair The thickness of the 5%~7% of quality, the CMC between hair cuticle and cortex cell is about 28nm.CMC lipid is in conjunction with protein Form lipoprotein, a continuous reticular structure can be formed around hair fiber, played between hair cuticle cell, hair cuticle and Adhesive effect between cortex cell.CMC lipid and people's horny layer of epidermis lipid are same, and main component is ceramide, gallbladder Sterol sulfuric ester, cholesterol, fatty alcohol and free alkyl alcohol.
In life, the pollution of urban environment, the arrangement of ultraviolet radiation, agent for permanent hair waving, hair dye, bleaching agent and hair (hair washing, blowing and combing) etc. can cause hair damage to some extent.High-sulfur egg in hair hair cuticle and cortex cell White is the important component for resisting extraneous various physics and chemical factor, once High-sulphur protein is destroyed, and it is serious to can lead to hair Fracture.Structured lipid (referring mainly to CMC) inside hair is the important adhesive of hair cuticle and cortex cell, and hair is by above-mentioned The influence of various physical chemical factors also results in CMC content in hair and reduces, as a result hair cuticle can be made to fall off, hair scale piece is stuck up It rises.
2 scalp problems
2.1 dandruff
Dandruff is a kind of scalp problems chronic, easy to recur, more typical, compares normal scalp, on scalp or in hair Laminar scurf occur is dandruff.Under normal circumstances, desquamation and cytothesis are in dynamic equilibrium, completely The keratinocyte aggregation composition diameter of angling maturation is less than the invisible agglomerate of 0.2mm and falls off.Macroscopic angling is thin Born of the same parents' agglomerate is then considered as dandruff, and pathologic finding shows as keratinocyte incomplete, undue growth, malalignment etc., and the scales of skin that peel off exists Microscopically observation is to remaining nucleus.Other than sheet furfur, the main clinical manifestation of dandruff is itch, dry scalp Tight, shouting pain, there are Sub-clinical inflammation changes.
The current puzzlement there are about 50% or more crowd by dandruff problem in the world, young artificial multiple crowd and Illness is heavier, and usual male's disease incidence is higher than women, and old man and child morbidity are lower.It is directed to dandruff mechanism at present In terms of research with means of prevention focuses primarily upon chlosma, and dandruff influence factor is numerous, and pathogenesis is complicated, is related to Scalp Tiny ecosystem, scalp physiology, many factors such as anti-oxidant are immunized in scalp lipid, and only being described the problem by chlosma is not No more.
(1) scalp adipose membrane and Tiny ecosystem
Sebum film is as made of the emulsification of the sebum of smegma, the sweat of sweat gland secretion and horn cell sheet lipid One layer of very thin film, scalp adipose membrane are the sebum films of scalp sites, protect people's scalp health under normal condition.Relative to face Portion's skin, scalp environment hair is vigorous, and sebaceous glands, the more secretory volumes of sweat gland quantity are big, therefore mineral ion, lipid, moisture etc. are Microorganism provides suitable growing environment and nutrient source abundant, and microbial origin esterase active is higher.Scalp micropopulation Plantation density is 103~105/mm2, Propionibacterium, staphylococcus and corynebacteria are most rich in healthy population and dandruff patient 3 kinds of rich bacteriums.Chlosma accounts for the 96% of total number of fungi on scalp, wherein restricted chlosma and Malassezia cilobosa are Dominant genera, dandruff crowd is compared with healthy population, and chlosma and staphylococcus epidermis quantity increase, and acne propionic acid bar The decline of bacterium number amount, this may be related with its strict anaerobic.
Most of chlosmas are lipid dependences, lack fatty acid synthetase gene, in order to overcome this defect, Chlosma has a large amount of fatty acid enzyme encoding gene compared with other fungies, and can use host source property lipid is certainly The secretion of body nutrient source, a variety of lipase of chlosma source property and phosphatidase etc., rouge needed for not only can compensate for its growth and breeding Fat acid, and it can be made to survive in the environment of lipid rich.
Chlosma by secretion lipase, can by sebum triglycerides and saturated fatty acid be decomposed into proinflammatory Unsaturated fatty acid, and these penetrations enter the scratchiness that cuticula not only causes scalp, but also can be with N- methyl- D-Asp (NMDA) receptor, which combines, makes flow of calcium ions, leads to corneocyte hyperplasia and keratinocyte exception and causes head The skin graft shape scales of skin that peel off generates.
Squalene is the important component of sebum, can be used as light protective barrier for skin of face first by oxygen Change, squalene peroxide is proven to have irritation on skin of face and causes keratinocyte proliferation and inflammatory reaction, together When penetrate into cellular layer influence immune system.The peroxidase of chlosma source property generates hydroxyl by generating hydroperoxides Base free radical and the generation for causing squalene peroxide.In addition, the lipoxygenase of chlosma source property can peroxidating it is free not Saturated fatty acid, triglycerides, cholesterol etc., product have cytotoxicity, have an effect in the mechanism of dandruff.
(2) scalp barrier function
Healthy population scalp is equally largely colonized chlosma and has no dandruff symptoms, in dandruff patient and Healthy People The oleic acid of equivalent is applied on group's scalp, furfur symptom will be further aggravated in dandruff patient, but healthy population does not generate furfur. Illustrate other than chlosma factor, scalp permeable barrier function is also an important factor for influencing dandruff.
The change of dandruff crowd's scalp barrier function, it may be possible to since scalp by longer-term damage (excessively scald by cleaning Dye, firmly grab around etc.) after, excite the inflammatory reaction of skin depths signal path, so as to cause scalp inflammation, a series of this barrier Dysfunction, will lead to epidermal cell abnormal differentiation and hyperplasia causes furfur.In addition, since sebum secretion is excessively vigorous and too late Shi Qingjie, living habit problem (share comb, pillow cover) etc. and the proliferation for causing scalp chlosma have irritating horse traction Color bacterium metabolite can destroy scalp barrier function.
Tiny ecosystem influences each other with scalp barrier function, and after scalp barrier function damage, one side external irritant is more It is easily accessible in cuticula, causes scalp that inflammatory reaction and abnormal furfur occurs.Head caused by another aspect barrier is impaired Skin pH, antibacterial peptide secretory volume etc. variation, may cause scalp microorganism group at and microbial activity change.In vitro in test It proves, is conducive to chlosma flourish when medium pH=6.2.
In addition, the lipid of dandruff head smegma penetrates into cuticula and is apparently higher than healthy scalp, i.e. dandruff There are a large amount of sebaceous gland lipids in scalp cuticula, these substances may destroy the institutional framework of lipid between cells of superficial layer, promote Make scalp desquamation, and is advantageously possible for field planting of the chlosma in cuticula.Change for lipid content, it may be possible to by It is proliferated in chlosma and increases transepidermal water loss rate (TWEL value), pH changes, and aquation weakens, and then influences lipid phase Close the activity of synzyme.
(3) epidermal structure function associated protein
A) silk polyprotein and natural moisturizing factor
The significant decrease of natural moisturizing factor NMF level may be related with impaired barrier.NMF main source is located at cuticula The silk polymeric protein (FLG) of lower layer hydrolyzes, and the NMF generated after hydrolysis reaches cuticula upper layer.And dandruff is characterized in excessively Proliferation and quick furfur, corneocyte processing maturation period shorten, therefore, before FLG is hydrolyzed and is generated NMF, keratinocyte May be mature and reach cuticula upper layer and fall off.
In addition, generating the final step of NMF in FLG, arginine protease -1 and gamma glutamylcyclotransferase can divide Urea and 2-pyrrolidone-5-carboxylic acid are not converted by arginine and gamma-glutamyl dipeptides, and both enzymes are expressed in dandruff skin Amount reduces, and for FLG precursor, related synzyme and hydrolase content are reduced, it may be possible to due to barrier function damage, or due to Water content in cuticula, the variation of pH and cause the activity of enzyme to change.
B) angling desmosome and its hydrolase
Angling desmosome primarily serves connection and fixed function between keratinocyte, can also will adjoin cuticula and closely be connected in one It rises, mainly desmoglein and desmoglein keratin are constituted.Angling desmosome can be discharged by serine protease-kassinin kinin Furfur is completed in the hydrolysis such as enzyme, protein lyase and cysteine proteinase-cathepsin.Peripheral angle bridge in dandruff scalp Grain, which is reduced, may cause the reduction of horn cell bonding force, and keratinocyte is easier to isolate and fall off, but due to sebum increase and The lipid of structure disturbance, the powerless cohesiveness between keratinocyte increase, and dandruff falls off in the form of sheets.
C) keratin and angling coating
Keratin is the main structural proteins of cuticula, is expressed by keratinocyte and generates and can be formed in iuntercellular Intermediate wire mesh structure maintains cyto-architectural stability and elasticity.When skin barrier is damaged, the expression of Epidermal Keratin is Disorder, classical marker of the keratin K1 and K10 as epidermal differentiation, the expression quantity in dandruff epidermis significantly reduces, Level is gone up after dandruff treatment.For dandruff scalp, barrier factor is removed the reason of keratin unconventionality expression Outside, it is also possible to have certain relationship with chlosma.
Angling coating is the important feature in keratinocyte differentiation latter stage and its maturation, by the regulation of glutamine transaminage. In dandruff scalp, participates in the generation of angling film and mature key enzyme transglutaminase -3 and 2 kind of glutamine turn amine - 1 processive enzyme of enzyme and cathepsin D's expression quantity significantly reduce.Cause this phenomenon that may change with water content of stratum corneum etc. It is related, it is also possible to related with chlosma metabolin.
The protein content variation to play a crucial role in barrier integrity and scalp cuticular tissue, shows scalp barrier It is impaired, and prompt incorrect differentiation and proliferation.
D) antibacterial skin and anti-oxidant variation
Ribalgilase is generated by keratinocyte, has the reactive protein of significant confrontation pathogenic microorganisms.In addition, There are also skins for antibacterial protein in cuticula from albumen, prolactin-inducible protein and Cystatin A, endogenic Antibacterial protein shows higher repellence to the microorganism of skin infection and invasion.
In dandruff scalp, the expression quantity of above-mentioned several albumen is reduced, some other Buchner's bodies such as apolipoprotein A-1 and histone H 4 have higher expression quantity, illustrate there are microorganism invasion, the state of this both effectiveness protein expression disorder, can It can be due to caused by the change of micropopulation in dandruff scalp environment.
The decline of dandruff scalp oxidation resistance, including superoxide dismutase and hydrogen peroxide enzyme level reduce, in head In scurf sebum, superoxide dismutase, catalase and PARK7 (DJ-1) are reduced, and show more than innate immune defence system System is affected, and antioxidant defense mechanisms are also affected.The raising of malonaldehyde and Vitamin E levels prompts dandruff scalp oxygen Change stress action degree to increase, may cause skin enhances the external sensibility of pollution and UV irradiation such as that infects.The above substance Variation may with microorganism change and metabolite invasion it is related.
E) inflammatory reaction
Inflammatory reaction is one of the feature of scalp skin damage, carries out pathology assessment to scalp tissue, has around blood vessel In the presence of leucocyte, there are slight inflammatory reactions for surface scalp.The value of 1L-1 α increases in dandruff scalp cuticula, when When barrier is impaired or epidermis is persistently inflamed cascade reaction, pre-existing 1L-1 α quick release, is exempting from cuticula Epidemic disease response upstream link can induce the synthesis of a variety of chemotactic factor (CF)s, reinforces T cell proliferation and B cell differentiation, has immunological regulation Effect.Biomarker when 1L-8 plays the role of chemotactic and activates neutrophil leucocyte and a cascade of response of inflammation, in head The horizontal also the same rising of its in scurf scalp, when dandruff is reduced, inflammation is reduced in living tissue, level decline.
Spherical, chaff chlosma is found to have activity of phospholipase, and the phosphatidase of chlosma source property can be catalyzed flower The synthesis of the raw inflammatory factors such as tetraenoic acid and prostaglandin, and inflammation is caused by this path.
In terms of problem and mechanism existing for the scalp, scalp grease excessive secretion how is effectively avoided to cause scalp greasy, horse Itching of the scalp caused by drawing color bacterium to be proliferated, furfur and scalp barrier injury realize water and oil balance adjusting and control, clean to scalp Clearly, it avoids bacterial multiplication active balance from providing basic guarantee, is the key that maintain scalp health.
3, technological core
From the point of view of domestic shampoo development course, the prevalence of no silicone oil shampoo is apodictic.Seventy or eighty years in 20th century It is had a single function for shampoo, focuses on cleaning function.Shield unification and submissive effect, Zhi Houxi were washed in shampoo emphasis since 1985 Product function of flooding segments more obvious, pure natural, plant type product first meeting clue, and the idea of people rises to correct hair and carries out The stage of total care.So far from 2000, product starts to pursue deep layer cleaning and deep layer reparation, people no longer meet simply It cleans, it is required that health cleaning from inside to outside.
Silicate-containing oil shampoo is used for a long time, silicone oil can be poly- in hair upper layer lamination, causes hair unnatural, greasy, thick and heavy, It collapses, dry up short-tempered, therefore the life style without silicone oil shampoo as a kind of health is come into being.Without silicone oil market fire Heat, what is really to wash shield product without silicone oil, and general no silicone oil product only merely removes silicone oil in formula, This is only the reprint for being not added with silicone oil shampoo the 1970s, and the decline of bring conditioning performance, is the retroversion of technology, because This not really washes shield product without silicon.
It really without silicone oil product is led under the development of the technologies such as mild surfactant, special grease, natural active products No silicone oil technology is crossed to realize, is naturally target so that mildly for theory, scalp care is core, it is mainly living with mild surface Property agent, substitute silicone oil conditioner and effectively nursing scalp at being grouped as, core is scalp maintenance.That is, without silicon Oil wash protect product should performance it is mild, using rear easy to clean, the effect for keeping hair smooth is equal to containing silicone oil product, most heavy That wants still has the function of nursing scalp.Scalp care is core effect that no silicone oil washes shield product, and to reach nursing head The effect of skin, scalp care component is essential, is passed through for different scalp problems using special effective care component Multi-functional prescription exists solving the problems, such as scalp care and pain spot.
The scalp ecological environment of health is by three kinds of balances to realize: grease balance, colony balance and barrier are sound.Scalp Excess grease secretion is the scalp problems root such as itching of the scalp, scalp desquamation, alopecia seborrheica.When scalp fat secretion is unbalance, Scalp fuel-displaced will become greasy, and when scalp flora environment is unbalance, harmful bacteria is largely bred, and just will appear the phenomenon that head is itched, and Scalp is coordinated in too fast situation, and cuticula, which falls off, just will appear dandruff.The present invention is mainly around the building scalp grease ecological balance.
When the sebaceous glands of healthy scalp relatively enlivens, since fat secretion is excessive, scalp will seem greasy.Sebaceous glands Activity is also had with the living habit of people, sanitary condition by the state of mind, the influence of plant type nervous system and gene It closes.Mainly by the control of male sex hormone, testosterone, dehydroisoandrosterone, all there is quantity in male and female in vivo for the secretion of sebum Not these equal substances.The feature that oiliness scalp shows in terms of physiology is mainly pore expansion, hyperkeratinization, skin microbial Increase, smegma is excessive, hair follicle inflammation, sebaceous glands expand etc..
The present invention restrains scalp pore using niacinamide, inositol, capriloyl glycine and oil-control plant extracts (M82N), Smegma and excretion are adjusted, fat secretion is inhibited, to reduce the greasy feeling of hair, restores scalp health.
3.1 niacinamide
The one kind of niacinamide as B family vitamin, have very high safety, and property stablize, be not easy by acid, alkali or By heat damage.
Niacinamide is able to maintain skin energy balance, while can restore cellular energy, accelerates collagen synthesis, to avoid flesh Skin is because fat content is low, and melanin transition is calm caused by cuticula is thinning.Niacinamide is promoted by accelerating skin to update Horn cell falls off, and niacinamide promotes the synthesis of epidermis protein, enhances the defence capability of skin itself, and it is aqueous to increase skin Rate.
Niacinamide enters in human body mutually to be converted with niacin, and niacin plays the role of expanding blood vessel and promote blood circulation. Therefore, niacinamide can promote hair follicle blood microcirculation, adjust fat secretion, realize water and oil balance.
3.2 inositol
Inositol is widely distributed in animal and plant body, is the growth factor of animal, microorganism.Inositol exists in nature There are multiple cis and trans isomers, naturally occurring isomers is cis- 1,2,3,5- trans- 4,6- inositol.At 80 DEG C or more from water Or inositol obtained in acetic acid be white crystal, 253 DEG C of fusing point, 1.752 gram per centimeter of density3(15 DEG C), it is sweet, be dissolved in water and Acetic acid, no optical activity.
Inositol is the ingredient contained in breast milk, is intracellular structural constituent, is important physiological property raw material.It is also skin Important substrate composition is organized, skin can be promoted to return to youth.Improve elasticity of skin, promotes skin moisture-retaining capacity, adjuster Skin fat secretion realizes water and oil balance.
3.3 capriloyl glycine
Capriloyl glycine is to be acylated synthesis of amphoteric molecular structure compound by octanoic acid and glycine.Glycine is albumen The important amino acid found in matter, the molecular structure that amphiphilic structure is made of a hydrophilic radical and a lipophilic group, is skin The natural component contained in skin is easy to be absorbed by the skin utilization.
A) skin acid barrier is rebuild
Acidity is presented in the skin of health, and alkalinity is presented in unhealthy skin, and capriloyl glycine contains free hydroxyl group, Neng Gouchong Build skin acid pH.
B) inhibit seborrhea
Capriloyl glycine can inhibit the bacterial multiplication of hair follicle generation, and the component is at low concentrations, associated for sebum Staphylococcus aureus, staphylococcus epidermis, propionibacterium acnes have good inhibiting effect, to reduce because of bacterial multiplication Caused inflammatory factor avoids sebaceous glands because inflammatory stimulus leads to excessive secretion, inhibits data as follows:
Germs (bacterium) Capriloyl glycine (MIC)
Staphylococcus aureus (pH=5) 0.025%a.m
Staphylococcus epidermis (pH=5) 0.12%a.m
Propionibacterium acnes (pH=7) 0.06%a.m
C) inhibit 5- alpha-reductase
Sebaceous glands fat secretion, 5α-reductase play decisive role, and the present invention takes capriloyl glycine to pass through to 5 'alpha ' reductase activity inhibits, and sebaceous glands grease excessive secretion is adjusted.
Muscle around scalp includes frontalis, occipitalis, ear week flesh, these muscle long terms can cause scalp as drum head one Sample is nervous.Since the blood supply of scalp is entered by periphery, so will subtract with blood flow at the tail vein at forehead top overhead Few, opposite hypoxemia and less capillary Reperfu- sion occur simultaneously for these positions.Under low-oxygen environment, dehydrogenation testosterone holds (DHT) it easily activates, these positions show high level DHT.DHT be it is direct destroy hair follicle cause hair stop fall off it is most main The factor wanted, meanwhile, DHT is the risk factor for directly resulting in a large amount of fat secretions of scalp.DHT can go deep into hair matricyte core, And the metabolism of cell is had an impact.DHT hinders the synthesis of the atriphos acted on as cellular energy, when as energy When the atriphos biosynthesis block in amount source, nucleus will be unable to carry out normal trichotrophy albumen synthesis, to cause hair Mother cell loses vigor, and hair follicle takes place keratinization, and hair normal development and then can not change to stand-down.Into stand-down Hair, will fall off within about 3 months, promoting blood circulation be determine hair follicle health key factor.
The present invention is had using capriloyl glycine inhibits 5α-reductase activity well, reduces its DHT in the scalp Content reduces the proliferation sebum basis of chlosma, effectively DHT is inhibited to destroy hair to avoid the excessive secretion of scalp grease Capsule leads to alopecia.
3.4 high-efficiency plant oil-control compositions
The present invention uses unique water soluble plant extract compound, by Europe medicine chrysanthemum, nettle, meadow pine, rosemary, honeybee Flower, horse chestnut, Salvia japonica and coltsfoot composition high-efficiency plant oil-control composition (M82N), have effects that releive calm.
1) Europe medicine chrysanthemum extract
Head titbit of the Europe medicine chrysanthemum extract from compositae plant chrysanthemum.Include volatile oil, choline, stachydrine, amino acid, Huang A variety of effective ingredients such as ketone and micro-element B1, chrysanthemum lactones, chrysanthone, chrysol.Its component can not only balanced fat secretion, Press down rouge anti-acne, prevents acne, and there is inhibition and bactericidal effect to the fungi of chlosma type.
2) nettle extract
For nettle just as medicinal since the Ancient Greece and Rome period, main component is coffee phthalein malic acid, is had anti-inflammatory Activity.It nettle preparation external curing seborrhea, dandruff and prevents hair loss.In Turkey, local herbal medicine expert is with nettle All herbal medicine prevents various diseases, can almost substitute all medicinal plants, referred to as " King of Herbs ".
3) Horsetail P.E
Rich in equisetonin, equisetrin, Isoquercitrin, galuteolin, silicic acid, (content reaches dry crude drug to Horsetail P.E 5.19~7.77%), organic acid, fat, cupreol, equisetine, dimethyl sulfone, chest pyrimidine, 3-Methoxy Pyridine, a variety of ammonia Base acid.Outside to mitigate inflammation and promote wound healing.It it is highly effective to reinforce connective tissue, while because of it to treating wound Astringing to arrest bleeding property its additionally aid bleeding ulcer healing.
4) Rosmarinus officinalis extract
The main component of Rosmarinus officinalis extract is rosmanol, carnosol and carnosic acid.In Rosmarinus officinalis extract Several main components all have stronger antioxidant activity.The antioxidant content extracted from rosemary is in addition to flavones, mainly Carnosol, carnosic acid, Rosmarinic acid and rosmanol, they all have the active site of phenol diterpene.In addition, in rosemary It is whole to show with adduction between these phenolic substancess also containing a variety of different phenols such as diterpene phenol, rosemary quinone The inoxidizability of body.
5) honeybee flower extract
Honeybee flower extract, medical product derive from lemon balm.Applied to cold, flu.Lemon balm is to do flavors and fragrances Rare raw material.Can also be used as medicine has the effect of calm of calming the nerves.
6) horse chestnut seed extract
Horse chestnut is deciduous tree, is distributed in the fallen leaves forest land in Europe.One of big shade tree in the world four.Horse chestnut seed extracts Object is rich in escin, flavonoids and tannin, it has the effect for the edema that strongly disappears, to varication, redness and inflammation skin The treatment of skin has special effect.
7) Sage extract
Vegetable phenol contained by Salvia japonica can resist bacterium and fungal infection, plants essential oil also releives, improve skin quality and Anti-oxidation efficacy has astriction to coarse pore, and the young woman of oily skin can be helped to improve or solve the problems, such as acne Puzzlement.
8) coltsfoot extract
Coltsfoot extract mainly contains the sterols such as arnidiol and isomers faradiol, still containing rutin, hyperin, Triterpenoid saponin, tannin, wax, volatile oil etc., spasm caused by histamine of releiving.
M82N combines eight kinds of plant components by scientific matching, can effectively inhibit fat secretion, restrains pore, releives Because of itch caused by scurf or seborrhea, can effectively inhibit for scalp fungi.
Sebum secretion object content is measured using 410 measuring method of Sebumeter SM, the transparent cassette tape of test application is drawn Sample skin surface sebum, skin sebum is more, then cassette tape is more transparent.Respectively to containing 10%M82N and without the essence of M82N Liquid is tested, and using warm water to Essence dilution 15%, respectively at morning and rear sebum is washed in (interval 8 hours) measurement at night Amount, test continue ten days, carry out in air-conditioned room, measure the dynamic variation of sebum secretion in six hours after applying, to embody To inhibition effect of sebum excretion rate, as a result as shown in Figure 1.Test result shows that M82N has the sebum secretion of skin and inhibits Effect.After the Essence containing M82N, sebum secretion amount has apparent reduction, has instant quick inhibitory effect, leads to Outside stimulus of the reduction to skin and scalp is crossed to inhibit sebum secretion.
In conclusion skin oil and fat balance composition of the invention has the advantages that
1) the problems such as above-mentioned skin oil and fat balance composition surrounds fuel-displaced scalp existing for scalp, itch, alopecia, using cigarette Amide, inositol, capriloyl glycine and M82N maintain grease balance, are effectively improved scalp problems.
2) present invention is had using capriloyl glycine inhibits 5α-reductase activity well, reduces its DHT in the scalp Content reduce the proliferation sebum basis of chlosma, effectively DHT inhibited to destroy to avoid the excessive secretion of scalp grease Hair follicle leads to alopecia.
3) present invention adjusts fat secretion using niacinamide, inositol and unique water soluble plant extract compound.It plants Object compound forms high-efficiency plant oil-control by Europe medicine chrysanthemum, nettle, meadow pine, rosemary, lemon balm, horse chestnut, Salvia japonica and coltsfoot Composition has effects that releive calm.
4) present invention uses grease balancing technique, and scalp fat content can effectively be inhibited to increase, and evaluates and tests through 3 hours, effectively Inhibiting scalp fat content to increase is 220.41%~281.9%, it was demonstrated that can effectively inhibit scalp fat secretion, can effectively subtract Few dandruff, seborrhea risk.
5) present invention uses water and oil balance mechanism, and when 90min can promote moisture content and be up to 62.3%~72.31%, 30.31%~40.32% is improved compared with control sample, it was demonstrated that can effectively promote scalp moisture levels.
Its core technology layout is as shown in the table.
In a specific example, skin oil and fat balance composition includes the component of following mass parts: 1~5 part of niacinamide, 0.1~0.5 part of inositol, 0.1~1 part of capriloyl glycine and 0.05~1 part of oil-control plant extracts.
In a specific example, skin oil and fat balance composition includes the component of following mass parts: 1~3 part of niacinamide, 0.1~0.3 part of inositol, 0.3~0.8 part of capriloyl glycine and 0.3~0.6 part of oil-control plant extracts.
In a specific example, skin oil and fat balance composition includes the component of following mass parts: 2 parts of niacinamide, flesh 0.2 part of alcohol, 0.5 part of capriloyl glycine and 0.5 part of oil-control plant extracts.
In a specific example, in oil-control plant extracts, Europe medicine chrysanthemum extract, nettle extract, Horsetail P.E, Rosmarinus officinalis extract, honeybee flower extract, horse chestnut seed extract, Sage extract and coltsfoot extract mass ratio are as follows:
(0.1~1): (0.1~1): (0.1~1): (0.1~1): (0.1~1): (0.1~1): (0.1~1): (0.1~ 1)。
In a specific example, oil-control plant extracts further includes following components: water, propylene glycol, ethoxydiglycol, Glucose and lactic acid.It is appreciated that these components are only used as auxiliary material, not as active constituent, can be selected according to product type etc. Whether add.
In a specific example, the composition of oil-control plant extracts is as shown in the table, but not limited to this, it can be according to product Type etc. needs to adjust the type and ratio of auxiliary material.
Component Mass percent (%)
Water 25~50
Propylene glycol 25~50
Ethoxydiglycol 10~25
Glucose 1~5
Lactic acid 1~5
Horse chestnut seed extract 0.1~1
Sage extract 0.1~1
Horsetail P.E 0.1~1
Coltsfoot extract 0.1~1
Rosemary leaf extract 0.1~1
Nettle extract 0.1~1
Europe medicine chrysanthemum extract 0.1~1
Honeybee flower extract 0.1~1
The present invention also provides a kind of above-mentioned skin oil and fat balance compositions in the application washed in shield product.
In a specific example, washes shield product and be selected from shampoo, hair conditioner, hair oil or scalp care Essence.
The present invention also provides one kind to wash shield product, including above-mentioned skin oil and fat balances composition.
In a specific example, wash further include in shield product following mass parts component: 2~4 parts of glycerol, propylene glycol 1~3 Part, 4~6 parts of butanediol, 0.005~0.015 part of oligomerization hyaluronic acid, 0.1~0.2 part of allantoin and 0.1~1 part of arginine. It is appreciated that these components are auxiliary material, it is not belonging to active constituent, can choose whether to add according to product type.
The following are specific embodiments.
One, scalp maintenance Essence is prepared
It is prepared into scalp maintenance Essence respectively according to the formula and prescription (surplus is deionized water) of following table, with example sample 2 For configuration technique it is as follows:
Glycerol, butanediol, propylene glycol, oligomerization hyaluronic acid, allantoin and xanthan gum (mass percent are weighed according to formula 0.15%) 75~80 DEG C, are heated to, with 500~600r/min, stirs 30min, until all dissolutions.Then cigarette is sequentially added Amide, inositol, caprylyl sweet acid, M82N and arginine stir 15min with 500~600r/min, complete until neutralizing, all Dissolution.Temperature is reduced to 38~45 DEG C, is added preservative PHL (mass percent 1%), with 150~200r/min, stirring 10min is cooled to room temperature.It is appreciated that preparation method is without being limited thereto, can be selected according to product type and usage mode It selects, preservative and other non-active ingredients can choose whether to add as needed.Oil-control plant extracts Central Europe medicine chrysanthemum extract, Nettle extract, Horsetail P.E, Rosmarinus officinalis extract, honeybee flower extract, horse chestnut seed extract, Sage extract and The mass ratio of coltsfoot extract is 1:1:1:1:1:1:1:1.
Two, effect is evaluated and tested
1, fat content measures
Test philosophy
The effect of carrying out oil-Absorbing Sheets using effect using the skin oil and fat tester Sebumeter SM815 of German CK is commented It is fixed.Using universally acknowledged SEBUMETER method, it is thick special of a kind of 0.1mm based on photometer principle for oil content test After delustring adhesive tape absorbs grease on human skin, a kind of translucent adhesive tape just will become, its light transmission capacity will become Change, the grease of absorption is more, and light transmission capacity will be bigger, can thus measure the content of skin oil and fat.Biggest advantage is It is small to test probe size, it is easy to use, any position of skin can be tested.This is a kind of indirect measurement of grease glandular secretion object As a result method can be used to distinguish different skin types, make accurately to understand the change of the grease as caused by inside and outside reason Change is possibly realized.
Test method
21 test objects of this time test selection, 3 one group of people are divided into 7 groups, respectively forehead draw 3 having a size of 3cm × The region 3cm carries out skin oil and fat for blank sample (not wipe samples), control sample 1 and other control samples and example sample respectively and contains Amount evaluation and test, each sample take the three related judges of value calculating fat content increment percentage progress for each person.The test object of selection Skin health, the age 18~30 years old, object informed consent after tested after study subject face cleaning 15 minutes, measured its forehead grease Content is as initial value.Sample is not smeared in subject's forehead blank area, 1st area of control sample, test block weigh 0.5ml and correspond to essence After liquid infiltrates cover skin 20min with 3cm × 3cm non-woven membrane cloth, non-woven fabrics is removed, waits for quietly 10 minutes, is directed to three respectively Region carries out fat content measurement, and every 30min test is primary, persistently evaluates and tests 3h.Test environment: T=25 DEG C of environment temperature of test, Humidity H=50.Testing time: carrying out face cleaning before testing, initial fat content tested after 15 minutes, distinguishes using after Essence Test the fat content data of 30min, 60min, 90min, 120min, 150min and 180min.
Test result
Blank group and each control sample, the testing result of example sample are as shown in following table and Fig. 2.
Conclusion: the skin oil and fat balance composition of present example sample uses grease balancing technique, can effectively inhibit scalp Fat content increases, and evaluates and tests within 3 hours, and it is 325%~386.49% that fat content, which increases, effectively inhibits scalp compared with control sample It is 220.41%~281.9% that fat content, which increases, it was demonstrated that skin oil and fat balance composition of the invention can effectively inhibit head Skin fat secretion effectively reduces the risk of dandruff, seborrhea.
2, skin moisture content MMV is tested
Test philosophy
For the method using the moisture content of capacitance method test human body keratoderma, its principle is based on water and other objects The difference in dielectric constant of matter is significant, and according to moisture content of skin difference, the capacitance for measuring skin is different, and observed parameter can represent Skin moisture value.
Test equipment
German CK company Multi-functional skin tester, model C UTOMETER DUAL MPA 580 select moisture of skin to contain Measure probe header and the lost TEWL test probe of moisture of skin.
Experimental condition and volunteer require
Test environment conditions: test environment temperature is 22 ± 1 DEG C, and relative humidity is 50% ± 5%, and is moved in real time State detection；
Volunteer requires: effective 30 people of volunteer, the age (gestation or breast feeding women except) between 16~65 years old, preceding Arm test zone capacitance method moisture of skin measures the basic value of meaning between 15~100, no serious systemic disease, lacks without immune It falls into or autoimmune disease person, no active anaphylactic disease person, previously to skin-care cosmetics without severe allergy history person, nearly one Hormone medicine and immunosuppressor person are not used in a month, other clinical test persons is not participated in, uses according to regulations test drug Object and all information, all volunteers fill in informed consent form before testing.
Prepare before test
Any product (cosmetics or topical drug) cannot be used within tested first 2~3 days.Before experiment, subject needs to agree to It cleans in both hands forearm and surveys, with dry face tissue wiped clean.Subject's both hands inner forearm carries out measured zone mark after cleaning Note.At least 30min that sits quietly in room should be being complied with standard before official testing, cannot drunk water, forearm exposure is put in test mode It sets, keeps loosening.
Testing procedure
3cm × 3cm test area is marked in experiment on the inside of left and right arm, same arm can mark multiple regions, region It is spaced 1cm.Test product and blank control are randomly dispersed in left and right arm.It is carried out using capacitance method skin analyzer tested The measurement in region and white space, each region is according to parallel determination 15 times.The plain pape for first measuring each test zone, is then pressed 2.0 ± 0.1mg sample/cm2Dosage, sample is spread evenly across in test area using latex finger cot.It is surveyed respectively after smearing Amount 0.5 hour, 1 hour, the moisture content of skin (being measured when verifying by this time) of 1.5 hours tested regions and white space, together The test of one volunteer is completed by the same survey crew.
Test data
Each control sample and the testing result of example sample are as shown in following table and Fig. 3.
Conclusion: the skin oil and fat balance composition of present example sample uses water and oil balance mechanism, and when 90min can be promoted Moisture content is up to 62.3%~72.31%, and 30.31%~40.32% is improved compared with control sample, can effectively promote scalp Moisture content.
Each technical characteristic of embodiment described above can be combined arbitrarily, for simplicity of description, not to above-mentioned reality It applies all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited In contradiction, all should be considered as described in this specification.
The embodiments described above only express several embodiments of the present invention, and the description thereof is more specific and detailed, but simultaneously It cannot therefore be construed as limiting the scope of the patent.It should be pointed out that coming for those of ordinary skill in the art It says, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to protection of the invention Range.Therefore, the scope of protection of the patent of the invention shall be subject to the appended claims.

Claims (10)

1. a kind of skin oil and fat balances composition, which is characterized in that planted including niacinamide, inositol, capriloyl glycine and oil-control Object extract；The oil-control plant extracts includes Europe medicine chrysanthemum extract, nettle extract, Horsetail P.E, rosemary extraction Object, honeybee flower extract, horse chestnut seed extract, Sage extract and coltsfoot extract.
2. skin oil and fat according to claim 1 balances composition, which is characterized in that the component including following mass parts: 1~5 part of niacinamide, 0.1~0.5 part of inositol, 0.1~1 part of capriloyl glycine and 0.05~1 part of oil-control plant extracts.
3. skin oil and fat according to claim 1 balances composition, which is characterized in that the component including following mass parts: 1~3 part of niacinamide, 0.1~0.3 part of inositol, 0.3~0.8 part of capriloyl glycine and 0.3~0.6 part of oil-control plant extracts.
4. skin oil and fat according to claim 1 balances composition, which is characterized in that the component including following mass parts: 2 parts of niacinamide, 0.2 part of inositol, 0.5 part of capriloyl glycine and 0.5 part of oil-control plant extracts.
5. skin oil and fat according to any one of claims 1 to 4 balances composition, which is characterized in that the oil-control plant In extract, the Europe medicine chrysanthemum extract, nettle extract, Horsetail P.E, Rosmarinus officinalis extract, honeybee flower extract, seven The mass ratio of leaf seeds of trees extract, Sage extract and coltsfoot extract is (0.1~1): (0.1~1): (0.1~1): (0.1~1): (0.1~1): (0.1~1): (0.1~1): (0.1~1).
6. skin oil and fat according to claim 5 balances composition, which is characterized in that the oil-control plant extracts also wraps Include following components: water, propylene glycol, ethoxydiglycol, glucose and lactic acid.
7. the described in any item skin oil and fat balance compositions of claim 1~6 wash the application in shield product in preparation.
8. application according to claim 7, which is characterized in that the shield product of washing are selected from shampoo, hair conditioner, hair oil or head Skin nurses Essence.
9. one kind washes shield product, which is characterized in that balance composition including the described in any item skin oil and fats of claim 1~6.
10. according to claim 9 wash shield product, which is characterized in that further include following components: glycerol, propylene glycol, fourth two Alcohol, oligomerization hyaluronic acid, allantoin and arginine.
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CN111110600A (en) * 2019-12-31 2020-05-08 泉后(深圳)投资发展有限公司 Scalp purification and hair growth promoting composition and emulsion thereof
CN111265439A (en) * 2020-02-11 2020-06-12 歆芳生物科技(广州)有限公司 Oil-control, dandruff-removing and itching-relieving shampoo and preparation method thereof
CN112089668A (en) * 2020-09-22 2020-12-18 沧州明辰生物科技有限公司 Balanced oil control essence and preparation method thereof
CN112870136A (en) * 2021-01-12 2021-06-01 吴维碧 Shampoo for patients with seborrheic dermatitis and preparation method thereof
CN113750009A (en) * 2021-09-03 2021-12-07 北京东方淼森生物科技有限公司 Preparation for improving scalp health state and preparation method thereof
CN116763695A (en) * 2023-07-18 2023-09-19 广东聚馨堂医药生物科技有限公司 Oil control composition beneficial to scalp regulation of water-oil balance and preparation method and application thereof

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CN105663020A (en) * 2016-02-19 2016-06-15 天津天狮生物发展有限公司 Spraying water with long-acting moisture-preserving capacity and preparation method thereof
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CN111110600A (en) * 2019-12-31 2020-05-08 泉后(深圳)投资发展有限公司 Scalp purification and hair growth promoting composition and emulsion thereof
CN111265439A (en) * 2020-02-11 2020-06-12 歆芳生物科技(广州)有限公司 Oil-control, dandruff-removing and itching-relieving shampoo and preparation method thereof
CN112089668A (en) * 2020-09-22 2020-12-18 沧州明辰生物科技有限公司 Balanced oil control essence and preparation method thereof
CN112870136A (en) * 2021-01-12 2021-06-01 吴维碧 Shampoo for patients with seborrheic dermatitis and preparation method thereof
CN113750009A (en) * 2021-09-03 2021-12-07 北京东方淼森生物科技有限公司 Preparation for improving scalp health state and preparation method thereof
CN113750009B (en) * 2021-09-03 2022-08-09 北京东方淼森生物科技有限公司 Preparation for improving scalp health state and preparation method thereof
CN116763695A (en) * 2023-07-18 2023-09-19 广东聚馨堂医药生物科技有限公司 Oil control composition beneficial to scalp regulation of water-oil balance and preparation method and application thereof
CN116763695B (en) * 2023-07-18 2024-03-12 广东聚馨堂医药生物科技有限公司 Oil control composition beneficial to scalp regulation of water-oil balance and preparation method and application thereof

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