CN112870136A

CN112870136A - Shampoo for patients with seborrheic dermatitis and preparation method thereof

Info

Publication number: CN112870136A
Application number: CN202110035785.6A
Authority: CN
Inventors: 吴维碧
Original assignee: Individual
Current assignee: Individual
Priority date: 2021-01-12
Filing date: 2021-01-12
Publication date: 2021-06-01

Abstract

The invention provides shampoo for patients with seborrheic dermatitis, which is prepared from the following raw materials in parts by weight: 15-25 parts of coconut oil diethanolamide, 4-8 parts of sodium laureth sulfate, 2-4 parts of coco glucoside, 1-3 parts of sodium hyaluronate, 0.5-0.8 part of loquat leaf extract, 0.5-1 part of aloe extract, 0.3-0.5 part of nettle extract, 0.2-0.6 part of spinach extract, 0.3-0.7 part of houttuynia cordata extract, 0.3-0.5 part of pine needle extract, 0.2-0.6 part of salvia miltiorrhiza extract and 75-95 parts of deionized water. The shampoo has the advantages of appropriate cleaning ability, mildness, no toxicity, no irritation, good effects of removing dandruff and oil, and is beneficial to relieving seborrheic dermatitis symptoms of patient head.

Description

Shampoo for patients with seborrheic dermatitis and preparation method thereof

Technical Field

The invention relates to the technical field of shampoo preparation, and particularly relates to shampoo for patients with seborrheic dermatitis and a preparation method thereof.

Background

Dandruff is medically known as pityriasis capitis, a skin disease caused by malassezia (one of the fungi). The mass propagation of malassezia on the scalp causes the hyperproliferation of the stratum corneum of the scalp, thereby promoting the abnormal falling of stratum corneum cells in the form of white or gray scales, and the fallen scales are the dandruff. The causes of dandruff are generally divided into physiological and pathological. Scurf is caused by the damage to the ecological balance of scalp, and when the secretion of oil and fat of scalp is unbalanced, the scalp can be oily; when the scalp flora is unbalanced in environment and a large amount of harmful bacteria are bred, the phenomenon of itching can occur; the stratum corneum of the scalp is metabolized too quickly and falls off to form dandruff.

Seborrheic dermatitis is a disease caused by the fact that sebaceous glands secrete vigorously, endocrine disorder and immune function decline, and a large amount of dandruff is generated for patients, although a plurality of dandruff-removing and deoiling shampoo products are available on the market. However, most of the products with good effects of removing dandruff and removing oil are added with chemical antibacterial agents, such as ketoconazole, climbazole, selenium disulfide and the like, but further damage to the scalp can be caused for a long time, and the product is not suitable for patients with seborrheic dermatitis. Chinese patent CN110063921A discloses a ginger nourishing shampoo and a preparation method thereof, wherein the ginger nourishing shampoo comprises the following raw materials: the shampoo is warm and low in stimulation, so that stimulation to the scalp is reduced while the scalp is cleaned, and fresh ginger extract can promote scalp blood circulation. However, the invention mainly takes the ginger extract as the functional raw material, the anti-dandruff oil-control function of the invention is relatively weak, and the invention has no relieving or repairing effect on seborrheic dermatitis.

Disclosure of Invention

The invention aims to provide the shampoo suitable for the patients with seborrheic dermatitis and the preparation method thereof aiming at the defects in the shampoo in the prior art.

In order to achieve the purpose, the following technical scheme is adopted in the application:

the shampoo for patients with seborrheic dermatitis is prepared from the following raw materials in parts by weight:

15-25 parts of coconut oil diethanolamide, 4-8 parts of sodium laureth sulfate, 2-4 parts of cocoglucoside, 1-3 parts of sodium hyaluronate, 2-4 parts of prinsepia utilis royle oil, 0.5-0.8 part of loquat leaf extract, 0.5-1 part of aloe extract, 0.3-0.5 part of nettle extract, 0.2-0.6 part of spinach extract, 0.3-0.7 part of houttuynia cordata extract, 0.3-0.5 part of pine needle extract, 0.2-0.6 part of salvia miltiorrhiza extract and 75-95 parts of deionized water.

The preparation method of the shampoo comprises the following steps:

s1: pulverizing folium Eriobotryae, Aloe, herba Urticae Cannabinae, herba Spinaciae, herba Houttuyniae, folium Pini, and Saviae Miltiorrhizae radix, granulating, and respectively preparing folium Eriobotryae extract, Aloe extract, herba Urticae Cannabinae extract, herba Spinaciae extract, herba Houttuyniae extract, folium Pini extract, and Saviae Miltiorrhizae radix extract by subcritical fluid extraction technology;

s2: adding 15-25 parts of coconut oil diethanolamide, 4-8 parts of sodium laureth sulfate, 2-4 parts of cocoglucoside and 75-95 parts of deionized water into a reaction kettle, heating to 80-90 ℃, and stirring at the speed of 500-800r/min for reaction for 15-25 min;

s3: cooling to 60-70 deg.C, adding 0.5-0.8 parts of folium Eriobotryae extract, 0.5-1 parts of Aloe extract, 0.3-0.5 parts of herba Urticae Cannabinae extract, 0.2-0.6 parts of herba Spinaciae extract, 0.3-0.7 parts of herba Houttuyniae extract, 0.3-0.5 parts of folium Pini extract, 0.2-0.6 parts of Saviae Miltiorrhizae radix extract into step S2, stirring at rate of 300-;

s4: adding 1-3 parts of sodium hyaluronate into the step S3, and stirring and reacting at the speed of 500-1000r/min for 30-60 min; cooling to room temperature to obtain the shampoo for patients with seborrheic dermatitis.

Preferably, in step S1, folium Eriobotryae, Aloe, herba Urticae Cannabinae, herba Spinaciae, herba Houttuyniae, folium Pini, and Saviae Miltiorrhizae radix are pulverized and granulated into granules with diameter of 5-8 mm.

Preferably, the extractant of the loquat leaves is n-butyl ether, the solid-to-liquid ratio of the two is 1:8-12, the extraction time is 0.5-1.5h, the resolution temperature is 55-65 ℃, the extraction temperature is 50-60 ℃, and the extraction pressure is 0.4-0.5 MPa; the extraction agent of the aloe is n-butyl ether, the solid-liquid ratio of the two is 1:5-10, the extraction time is 0.5-1.5h, the resolution temperature is 60-70 ℃, the extraction temperature is 55-65 ℃, and the extraction pressure is 0.3-0.4 MPa; the extracting agent of the nettle is n-butyl ether, the solid-liquid ratio of the two is 1:10-15, the extraction time is 1-2h, the resolution temperature is 65-75 ℃, the extraction temperature is 55-65 ℃, and the extraction pressure is 0.5-0.6 MPa; the spinach extracting agent is n-butyl ether, the solid-liquid ratio of the n-butyl ether to the n-butyl ether is 1:10-20, the extraction time is 0.5-1.5h, the resolving temperature is 70-80 ℃, the extraction temperature is 60-70 ℃, and the extraction pressure is 0.4-0.5 MPa; the extractant of the houttuynia cordata is n-butyl ether, the solid-liquid ratio of the n-butyl ether to the n-butyl ether is 1:8-15, the extraction time is 1-2h, the resolution temperature is 60-70 ℃, the extraction temperature is 55-65 ℃, and the extraction pressure is 0.4-0.5 MPa; the extracting agent of the pine needles is n-butyl ether, the solid-liquid ratio of the n-butyl ether to the n-butyl ether is 1:15-25, the extraction time is 0.5-1h, the resolving temperature is 75-85 ℃, the extraction temperature is 70-80 ℃, and the extraction pressure is 0.5-0.6 MPa; the radix Salviae Miltiorrhizae extract is n-butyl ether with a solid-to-liquid ratio of 1:5-12, extraction time of 1-2h, resolving temperature of 85-95 deg.C, extraction temperature of 80-90 deg.C, and extraction pressure of 0.3-0.4 MPa.

Preferably, in step S2, 20 parts of coconut diethanolamide, 5 parts of sodium laureth sulfate, 3 parts of cocoglucoside and 90 parts of deionized water are added into a reaction kettle, the temperature is raised to 85 ℃, and the reaction is stirred at the speed of 650r/min for 18 min.

Preferably, the temperature is reduced to 63 ℃ in step S3, 0.6 parts of loquat leaf extract, 0.8 parts of aloe extract, 0.4 parts of nettle extract, 0.4 parts of spinach extract, 0.5 parts of houttuynia extract, 0.4 parts of pine needle extract and 0.5 parts of salvia miltiorrhiza extract are added to step S2, and the mixture is stirred at a speed of 600r/min for 3 hours.

Preferably, 2 parts of sodium hyaluronate are added in step (a) and the reaction is stirred at a rate of 800r/min for 45 min.

Has the advantages that:

1. aiming at the scalp characteristics of patients with seborrheic dermatitis, three surfactants of coconut oil diethanolamide, sodium laureth sulfate and cocoglucoside are selected for compounding; the sodium laureth sulfate has the advantages of high yield, low price, cost advantage, excellent foaming and decontamination capability, but slight irritation; the coconut oil diethanolamide has the performances of wetting, thickening, cleaning, emulsifying, foam stabilizing, softening and the like, and has a good foam stabilizing effect on an anionic surfactant; however, the two components used independently have strong degreasing force, so that hair is astringent and unsmooth after shampooing; the irritation caused by the sodium laureth sulfate surfactant can be reduced by using the coco glucoside serving as the nonionic surfactant, and the biodegradable performance and the foam stabilizing capability are strong; thus, not only the requirement of cleaning is met, but also the scalp is not stimulated, and the further aggravation of the disease condition is prevented.

2. The invention is added with loquat leaf extract, aloe extract, nettle extract, spinach extract, houttuynia extract, pine needle extract and red sage root extract, and regulates oily scalp by scientific proportioning. On one hand, the content of DHT in scalp is reduced by inhibiting the activity of 5 alpha-reductase, the excessive secretion of scalp grease is avoided, the proliferation sebum base of malassezia is reduced, and the hair loss caused by hair follicle damage caused by DHT is effectively inhibited; on the other hand, the composition inhibits bacterial proliferation generated by hair follicles, particularly has good inhibition effect on sebum-associated staphylococcus aureus, staphylococcus epidermidis and propionibacterium acnes, reduces inflammatory factors by inhibiting bacterial proliferation, and avoids excessive secretion of sebaceous glands due to inflammatory stimulation; thereby achieving the purposes of balancing the secretion of grease, reducing the generation of dandruff, preventing alopecia and relieving the symptoms of seborrheic dermatitis.

3. When the extract is added, the foaming performance of the product is affected; however, under the action of flavonoid substances in extracts of loquat leaves, pine needles and the like, hydrophilic groups and hydrophobic groups of the extracts are distributed on the surface of water in water, the hydrophilic groups face the water and form hydrogen bonds with the water, and the hydrophobic groups face air, so that a monomolecular film consisting of surfactant hydrophobic groups is formed on the surface of the water, the surface energy of the system is reduced, the surface tension is further reduced, and the foaming performance is improved.

4. The sodium hyaluronate is added to form a macromolecular reticular structure, so that the adhesive force of the extract can be obviously improved, and the effective ingredients can be remained on the surface for a long time and intensively; meanwhile, the good water absorption effect of the cream is utilized to reduce the percutaneous loss of water, so that the stratum corneum of people keeps a certain water content, and the generation of dandruff and seborrheic dermatitis which are aggravated by dryness are prevented.

5. In order to better obtain the extract, the invention adopts the technology of crushing granulation and then subcritical fluid extraction, and the extraction speed is high because a large number of micropores exist in the prepared particles and the solvent is easy to permeate through crushing granulation; in addition, gaps among particles are larger than those of the powder, so that the solvent is easier to flow through, the filtering speed is high, the content of active ingredients of the prepared extract is higher, and the effect of the prepared shampoo is better.

Detailed Description

The present invention is further illustrated below by reference to the following examples, which are intended to be illustrative of the invention only and are not intended to be limiting.

The preparation process conditions of the extracts are as follows:

the extracting agent of the loquat leaves is n-butyl ether, the solid-to-liquid ratio of the n-butyl ether to the loquat leaves is 1:8-12, the extraction time is 0.5-1.5h, the resolution temperature is 55-65 ℃, the extraction temperature is 50-60 ℃, and the extraction pressure is 0.4-0.5 MPa; the extraction agent of the aloe is n-butyl ether, the solid-liquid ratio of the two is 1:5-10, the extraction time is 0.5-1.5h, the resolution temperature is 60-70 ℃, the extraction temperature is 55-65 ℃, and the extraction pressure is 0.3-0.4 MPa; the extracting agent of the nettle is n-butyl ether, the solid-liquid ratio of the two is 1:10-15, the extraction time is 1-2h, the resolution temperature is 65-75 ℃, the extraction temperature is 55-65 ℃, and the extraction pressure is 0.5-0.6 MPa; the spinach extracting agent is n-butyl ether, the solid-liquid ratio of the n-butyl ether to the n-butyl ether is 1:10-20, the extraction time is 0.5-1.5h, the resolving temperature is 70-80 ℃, the extraction temperature is 60-70 ℃, and the extraction pressure is 0.4-0.5 MPa; the extractant of the houttuynia cordata is n-butyl ether, the solid-liquid ratio of the n-butyl ether to the n-butyl ether is 1:8-15, the extraction time is 1-2h, the resolution temperature is 60-70 ℃, the extraction temperature is 55-65 ℃, and the extraction pressure is 0.4-0.5 MPa; the extracting agent of the pine needles is n-butyl ether, the solid-liquid ratio of the n-butyl ether to the n-butyl ether is 1:15-25, the extraction time is 0.5-1h, the resolving temperature is 75-85 ℃, the extraction temperature is 70-80 ℃, and the extraction pressure is 0.5-0.6 MPa; the radix Salviae Miltiorrhizae extract is n-butyl ether with a solid-to-liquid ratio of 1:5-12, extraction time of 1-2h, resolving temperature of 85-95 deg.C, extraction temperature of 80-90 deg.C, and extraction pressure of 0.3-0.4 MPa.

The conditions are screened to obtain the following optimal preparation process conditions of the extract:

preparing a loquat leaf extract: adding n-butyl ether into folium Eriobotryae, and extracting with subcritical fluid extraction technology at 60 deg.C for 1 hr, 55 deg.C and 0.45MPa to obtain extract;

preparing an aloe extract: adding n-butyl ether into Aloe, with a solid-to-liquid ratio of 1:8, and extracting with subcritical fluid extraction technology at a temperature of 65 deg.C for 1h and 60 deg.C under 0.35MPa to obtain extract;

preparing the nettle extract: adding n-butyl ether into herba Urticae Cannabinae at a solid-to-liquid ratio of 1:12, and extracting with subcritical fluid extraction technology at 65 deg.C for 1.5h and 60 deg.C under 0.55MPa to obtain extract;

preparing spinach extract: adding n-butyl ether into spinach at a solid-liquid ratio of 1:15, and extracting for 1h at 75 deg.C under 0.45MPa by subcritical fluid extraction technique to obtain extract;

preparing a houttuynia cordata extract: adding n-butyl ether into herba Houttuyniae at a solid-to-liquid ratio of 1:10, extracting for 1.5h at a resolution temperature of 65 deg.C and an extraction temperature of 60 deg.C under an extraction pressure of 0.45MPa to obtain extract;

preparing a pine needle extract: adding n-butyl ether into folium Pini at a solid-to-liquid ratio of 1:20, extracting for 50min at a resolving temperature of 80 deg.C and an extraction temperature of 75 deg.C under an extraction pressure of 0.55MPa to obtain extract;

preparing a salvia miltiorrhiza extract: adding n-butyl ether into Saviae Miltiorrhizae radix at a solid-to-liquid ratio of 1:10, extracting for 1.5h at resolving temperature of 90 deg.C and extraction temperature of 85 deg.C under extraction pressure of 0.35 MPa.

Example 1

S1: pulverizing folium Eriobotryae, Aloe, herba Urticae Cannabinae, herba Spinaciae, herba Houttuyniae, folium Pini, and Saviae Miltiorrhizae radix, granulating into granules with diameter of 5-8mm, and respectively preparing folium Eriobotryae extract, Aloe extract, herba Urticae Cannabinae extract, herba Spinaciae extract, herba Houttuyniae extract, folium Pini extract, and Saviae Miltiorrhizae radix extract by subcritical fluid extraction technology;

s2: adding 15 parts of coconut oil diethanolamide, 4 parts of sodium laureth sulfate, 2 parts of cocoglucoside and 75 parts of deionized water into a reaction kettle, heating to 80 ℃, and stirring at the speed of 500r/min for reaction for 15 min;

s3: cooling to 80 deg.C, adding 0.5 parts of folium Eriobotryae extract, 0.5 parts of Aloe extract, 0.3 parts of herba Urticae Cannabinae extract, 0.2 parts of herba Spinaciae extract, 0.3 parts of herba Houttuyniae extract, 0.3 parts of folium Pini extract, and 0.2 parts of Saviae Miltiorrhizae radix extract in step S2, and stirring at rate of 300r/min for 2 hr;

s4: adding 1 part of sodium hyaluronate into the step S3, and stirring and reacting at the speed of 500r/min for 30 min; cooling to room temperature to obtain the shampoo for patients with seborrheic dermatitis.

Example 2

s2: adding 25 parts of coconut oil diethanolamide, 8 parts of sodium laureth sulfate, 4 parts of cocoglucoside and 95 parts of deionized water into a reaction kettle, heating to 90 ℃, and stirring at the speed of 800r/min for reaction for 25 min;

s3: cooling to 100 deg.C, adding respectively 0.8 parts of folium Eriobotryae extract, 1 part of Aloe extract, 0.5 parts of herba Urticae Cannabinae extract, 0.6 parts of herba Spinaciae extract, 0.7 parts of herba Houttuyniae extract, 0.5 parts of folium Pini extract, and 0.6 parts of Saviae Miltiorrhizae radix extract into step S2, and stirring at speed of 800r/min for 4 hr;

s4: adding 3 parts of sodium hyaluronate into the step S3, and stirring and reacting at the speed of 1000r/min for 60 min; cooling to room temperature to obtain the shampoo for patients with seborrheic dermatitis.

Example 3

s2: adding 25 parts of coconut oil diethanolamide, 5 parts of sodium laureth sulfate, 3 parts of coco glucoside and 90 parts of deionized water into a reaction kettle, and stirring at the speed of 650r/min for reacting for 18 min;

s4: cooling to 90 deg.C, adding folium Eriobotryae extract 0.6 parts, Aloe extract 0.8 parts, herba Urticae Cannabinae extract 0.4 parts, herba Spinaciae extract 0.4 parts, herba Houttuyniae extract 0.5 parts, folium Pini extract 0.4 parts, and Saviae Miltiorrhizae radix extract 0.5 parts into step S2 respectively at step S3, and stirring at rate of 600r/min for 3 hr;

s5: adding 2 parts of sodium hyaluronate into the step S3, and stirring and reacting at the speed of 800r/min for 45 min; cooling to room temperature to obtain the shampoo for patients with seborrheic dermatitis.

Comparative example 1

The difference from example 1 is that the preparation method of the extract in step S1 is different, and the extract of each material is prepared by the common dipping extraction method under the same temperature and time conditions, and other steps and conditions are not changed.

Comparing the performance data of comparative example 1 and example 1, it can be seen that the concentration and components of the obtained extract are limited by using the common dipping extraction method, and the finally prepared shampoo has poor effect.

Comparative example 2

The difference from example 1 is that no coco glucoside was added in step S2, and other steps and conditions were unchanged.

Comparing the performance data of comparative example 2 and example 1, it can be seen that the shampoo prepared by adding the sodium laureth sulfate surfactant has certain irritation, and is not suitable for patients with seborrheic dermatitis.

Comparative example 3

The difference from example 1 is that the temperature is 50 ℃ in step S3, stirring is carried out for 30min, and other steps and conditions are not changed.

Comparative example 4

The difference from example 1 is that the temperature in step S3 is 120 ℃, stirring is carried out for 5h, and other steps and conditions are not changed.

Comparing the performance data of comparative example 3, comparative example 4 and example 1, when the reaction temperature is too low and the stirring time is too short, the reaction between the extracts is insufficient, which affects the overall performance of the product; when the reaction temperature is too high and the stirring time is too long, the product performance tends to be stable, and even some side reactions can be brought to influence the product quality.

Comparative example 5

The difference from example 1 is that in step S3, there are no nettle extract, spinach extract, salvia miltiorrhiza extract; other steps and conditions were unchanged.

Comparing the performance data of comparative example 5 and example 1, it is understood that the scalp fat balance performance is lowered due to the absence of the above extract, which is probably due to insufficient 5 α -reductase inhibitory activity, lowered scalp fat over-secretion inhibitory performance, and the generation of dandruff.

Comparative example 6

The difference from example 1 is that the loquat leaf extract, the aloe extract, and the pine needle extract are absent in step S3; other steps and conditions were unchanged.

Comparing the performance data of comparative example 5 and example 1, the scalp lipid balance performance is reduced due to the lack of the above extract, which may be due to insufficient bacteriostatic effect, failure to effectively inhibit bacterial proliferation, reduction of inflammatory factors, secretion of sebaceous glands due to inflammatory stimulation, and dandruff generation.

Comparative example 7

The difference from example 1 is the absence of the addition of sodium hyaluronate in step S4; other steps and conditions were unchanged.

Comparing the performance data of comparative example 7 and example 1, it can be seen that the adhesive force of the effective components of the extract is reduced and the performance in oil control, dandruff removal, maintenance, moisture retention and the like is reduced due to the lack of sodium hyaluronate and the formation of macromolecular network structure.

Comparative example 8

The difference from example 1 is that in step S1, extraction was performed as powder without granulation, and other steps and conditions were not changed.

Comparing the performance data of comparative example 8 and example 1, it can be seen that by pulverizing and granulating, the extraction speed is fast because of the large amount of micropores in the prepared granules and the easy penetration of the solvent; in addition, the gaps among the particles are larger than those of the powder, so that the solvent is easier to flow through, the filtering speed is high, and the content of the extracted effective components is higher.

Skin irritation and allergy test

Test animals: 50 young guinea pigs weighing about 200g were obtained.

The test method comprises the following steps: dividing guinea pigs into 10 groups randomly, dividing each group into 5 guinea pigs, shaving the backs of the guinea pigs (the shaving area is 3 multiplied by 3cm), applying the shampoo prepared in the examples and the comparative examples on the hair-removed areas of the guinea pigs after 24h, washing the shampoo with warm water after 30min, observing whether the skin of the guinea pigs has erythema or edema after 1h and 24h after washing the shampoo, judging the stimulation intensity, observing whether the skin has the skin allergy phenomenon at the same time, and observing whether the allergy phenomenon (namely symptoms such as uneasiness, nose grabbing, sneezing, dyspnea, hair erection, incontinence of urine and feces, spasmodic jump or death and the like) again after 24h, wherein the guinea pigs are divided into 5 groups, 4 groups, 3 groups, 2 groups and 1 group which are very satisfied; the results were averaged.

Second, the oil control effect test

Selecting 50 volunteers with much dandruff and oily hair, wherein the volunteers are aged between 15-60 years, randomly dividing the volunteers into 5 groups of 10 persons, respectively using the shampoos of the examples and the comparative examples, washing hair once every morning, and observing the oily dandruff removal and scalp moisturizing conditions in the morning of the next day after continuously washing hair for one week, wherein the volunteers are very satisfied with 5 points, satisfied with 4 points, general 3 points, unsatisfied with 2 points and very unsatisfied with 1 point; the results were averaged.

Third, experiment of nourishing and moistening hair

Selecting 50 volunteers with much dandruff and oily hair, wherein the age is 15-60 years, randomly dividing the volunteers into 5 groups, and 10 people in each group use the shampoos in the examples and the comparative examples respectively to shampoo once every morning, and observing the hair nourishing and moistening effect conditions in the morning next day after one month of continuous shampooing, wherein the hair nourishing and moistening effects are 5 points which are satisfied, 4 points which are satisfied, 3 points which are general, 2 points which are not satisfied and 1 point which is not satisfied; the results were averaged.

Fourth, testing the bacteriostatic effect

Perforating with a flat plate, and setting the concentration to 1 × 10 with sterile cotton swab⁴-9×10⁴The method comprises the following steps of uniformly smearing a test bacterial suspension of cfu/mL on the surface of a lecithin Tween-80 nutrient agar plate culture medium for 3 times, placing the culture dish for drying at room temperature for 5min, punching the hole by using a sterile circular puncher with the diameter of 6mm, taking a proper amount of shampoo sample, diluting the shampoo sample by 100 times by using normal saline, adding the diluted shampoo sample into the hole until the shampoo sample is filled, performing 3 groups of parallel experiments until the shampoo sample cannot overflow, placing the culture dish in a (36 +/-1) DEG C constant temperature box for culturing for 16-18h, taking out the culture dish for observation, measuring the diameter of a bacteriostatic circle by using a caliper, taking the outer edge of the bacteriostatic circle with complete sterile growth as a boundary, and judging the judgment standard of the bacteriostatic experiment result of the antibiotic is that the bacteriostatic circle with the diameter of 15mm is most sensitive, 10-15mm is moderate sensitive, 7-9.

Fifthly, degree of foaming and cleanliness

Selecting 50 volunteers with more dandruff and oily hair, wherein the volunteers are aged between 15-60 years, randomly dividing the volunteers into 5 groups of 10 persons, respectively using the shampoos of the examples and the comparative examples, washing hair once in the morning, and observing the degree of foam and cleanliness, wherein the contents are 5, 4, 3, 2 and 1; the results were averaged.

The results are as follows:

the above description is only a preferred embodiment of the present invention, and the scope of the present invention is not limited to the above embodiment, but equivalent modifications or changes made by those skilled in the art according to the present disclosure should be included in the scope of the present invention as set forth in the appended claims.

Claims

1. The shampoo for patients with seborrheic dermatitis is characterized by being prepared from the following raw materials in parts by weight:

15-25 parts of coconut oil diethanolamide, 4-8 parts of sodium laureth sulfate, 2-4 parts of coco glucoside, 1-3 parts of sodium hyaluronate, 0.5-0.8 part of loquat leaf extract, 0.5-1 part of aloe extract, 0.3-0.5 part of nettle extract, 0.2-0.6 part of spinach extract, 0.3-0.7 part of houttuynia cordata extract, 0.3-0.5 part of pine needle extract, 0.2-0.6 part of salvia miltiorrhiza extract and 75-95 parts of deionized water.

2. The preparation method of the shampoo for the seborrheic dermatitis patient is characterized by comprising the following steps of:

s3: cooling to 80-100 deg.C, adding 0.5-0.8 parts of folium Eriobotryae extract, 0.5-1 parts of Aloe extract, 0.3-0.5 parts of herba Urticae Cannabinae extract, 0.2-0.6 parts of herba Spinaciae extract, 0.3-0.7 parts of herba Houttuyniae extract, 0.3-0.5 parts of folium Pini extract, 0.2-0.6 parts of Saviae Miltiorrhizae radix extract into step S2, stirring at rate of 300-;

3. The method of claim 2, wherein in step S1, the loquat leaves, the aloe, the nettle, the spinach, the houttuynia, the pine needles and the red sage root are pulverized and granulated into particles with a diameter of 5-8 mm.

4. The preparation method of the shampoo for the patients with the seborrheic dermatitis as claimed in claims 2 to 3, wherein the extracting agent of the loquat leaves is n-butyl ether, the solid-to-liquid ratio of the n-butyl ether to the n-butyl ether is 1:8-12, the extraction time is 0.5-1.5h, the resolving temperature is 55-65 ℃, the extraction temperature is 50-60 ℃, and the extraction pressure is 0.4-0.5 MPa; the extraction agent of the aloe is n-butyl ether, the solid-liquid ratio of the two is 1:5-10, the extraction time is 0.5-1.5h, the resolution temperature is 60-70 ℃, the extraction temperature is 55-65 ℃, and the extraction pressure is 0.3-0.4 MPa; the extracting agent of the nettle is n-butyl ether, the solid-liquid ratio of the two is 1:10-15, the extraction time is 1-2h, the resolution temperature is 65-75 ℃, the extraction temperature is 55-65 ℃, and the extraction pressure is 0.5-0.6 MPa; the spinach extracting agent is n-butyl ether, the solid-liquid ratio of the n-butyl ether to the n-butyl ether is 1:10-20, the extraction time is 0.5-1.5h, the resolving temperature is 70-80 ℃, the extraction temperature is 60-70 ℃, and the extraction pressure is 0.4-0.5 MPa; the extractant of the houttuynia cordata is n-butyl ether, the solid-liquid ratio of the n-butyl ether to the n-butyl ether is 1:8-15, the extraction time is 1-2h, the resolution temperature is 60-70 ℃, the extraction temperature is 55-65 ℃, and the extraction pressure is 0.4-0.5 MPa; the extracting agent of the pine needles is n-butyl ether, the solid-liquid ratio of the n-butyl ether to the n-butyl ether is 1:15-25, the extraction time is 0.5-1h, the resolving temperature is 75-85 ℃, the extraction temperature is 70-80 ℃, and the extraction pressure is 0.5-0.6 MPa; the radix Salviae Miltiorrhizae extract is n-butyl ether with a solid-to-liquid ratio of 1:5-12, extraction time of 1-2h, resolving temperature of 85-95 deg.C, extraction temperature of 80-90 deg.C, and extraction pressure of 0.3-0.4 MPa.

5. The method for preparing a shampoo for patients with seborrheic dermatitis as claimed in claim 2, wherein 20 parts of coconut diethanolamide, 5 parts of sodium laureth sulfate, 3 parts of cocoglucoside and 90 parts of deionized water are added into the reaction kettle in step S2, the temperature is raised to 85 ℃, and the reaction is stirred at a speed of 650r/min for 18 min.

6. The method of claim 2, wherein the temperature of step S3 is reduced to 63 ℃, and 0.6 part of folium Eriobotryae extract, 0.8 part of Aloe extract, 0.4 part of herba Urticae Cannabinae extract, 0.4 part of herba Spinaciae extract, 0.5 part of herba Houttuyniae extract, 0.4 part of folium Pini extract, and 0.5 part of Saviae Miltiorrhizae radix extract are added to step S2, and the mixture is stirred at a rate of 600r/min for 3 h.

7. The method for preparing shampoo for seborrheic dermatitis patients according to claim 2, wherein 2 parts of sodium hyaluronate are added in the step, and the reaction is stirred at the speed of 800r/min for 45 min.