CN111419756A - Dandruff-removing itching-relieving nursing essence and production process thereof - Google Patents
Dandruff-removing itching-relieving nursing essence and production process thereof Download PDFInfo
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Abstract
The invention relates to a hair care composition, in particular to an anti-dandruff itching-relieving care essence and a production process thereof, wherein the care essence is prepared from the following raw materials: myrobalan, paeonol, fructus cnidii, purslane, citral, eugenol, glycerol, seaweed extract, EDTA-2 sodium, 130w sodium hyaluronate, polyglutamic acid, trehalose, polyglyceryl ether-26, biological polysaccharide gum-1, aminomethyl propanol, DSBC silanol salicylate, 1,3 butanediol and preservative; the anti-dandruff itching-relieving nursing essence has the following characteristics: clearing away heat and toxic materials, inhibiting bacteria, and eliminating pathogenic bacteria and fungi growth on scalp surface; nourishing blood, promoting blood circulation, dispelling pathogenic wind, relieving itching, relieving scalp itching, and enhancing scalp skin immunity; repairing scalp barrier, regulating microbial flora, and preventing hair line retrogradation.
Description
Technical Field
The invention belongs to the field of hair care products, and particularly relates to an anti-dandruff itching-relieving nursing essence and a production process thereof.
Background
Dandruff is a phenomenon of massive desquamation caused by excessive proliferation of scalp keratinocytes, and about 60% of adults in china suffer from dandruff problems to varying degrees, of which about 15% have severe symptoms. Researches show that various lipophilic malassezia are found in dandruff, wherein malassezia restricta, malassezia globosa and malassezia blunt are the most common, and dandruff caused by malassezia restricta is easier to treat. At the world university of Paris at the dermatological university, scientists of the United states cleaning company have announced that this dandruff is caused by the fatty metabolic wastes of two fungi, malassezia restricta and malassezia globosa. Therefore, inhibiting the growth of malassezia and eliminating metabolic waste produced by malassezia remain a very critical method for treating dandruff.
At present, most of the anti-dandruff agents added in anti-dandruff shampoos and other anti-dandruff products in the market are zinc pyrithione, climbazole and the like, and ketoconazole medicines such as Caile king are even used for people with serious dandruff. However, such an antidandruff agent has a good antifungal effect, but has poor solubility and high degreasing ability. The long-term use of the hair conditioner can cause the hair to be dry and thick, destroy the scalp structure, disturb the balance of the epidermis, cause the scalp to be itchy and the like. Among them, zinc pyrithione may cause heat shock of human keratinocytes and melanocytes and cause DNA damage.
With the popularity of environmental protection, low carbon, green and natural trend in recent years, the plant anti-dandruff product is also a hot point of research and is more and more concerned and favored by people. The plant dandruff remover fundamentally blocks external channels generated by dandruff through methods of sterilization, antioxidation, peroxide decomposition and the like. Therefore, the functional additives such as the anti-dandruff additive are developing towards safer plant raw materials, and future hair products are developing towards safer, milder, environment-friendly and efficient plant resources.
The traditional Chinese medicine extract is more important for the drug sensitivity experimental study of the limited malassezia. The Chinese medicinal extract used as the anti-dandruff agent conforms to the development trend of anti-dandruff cosmetics, and fully utilizes the multiple efficacies of the Chinese medicinal extract components to achieve the comprehensive effects of protecting, nourishing and nourishing the scalp. Based on the above, the invention provides an anti-dandruff itching-relieving nursing essence and a production process thereof.
Disclosure of Invention
The invention aims to provide an anti-dandruff itching-relieving nursing essence and a production process thereof, the hair care essence is prepared by taking the effect of 'dispelling wind and relieving itching' of fructus cnidii according to the formula principle of 'monarch, minister, assistant and guide', taking the advantage of convergence and bacteriostasis of myrobalan, and the effects of clearing heat, cooling blood and relieving itching of cortex moutan radicis, and the anti-inflammatory and soothing effects of purslane are obtained, so that the optimal synergistic effect is realized by optimizing the formula ratio.
In order to achieve the above object, the present invention adopts the following technical solutions
An anti-dandruff itching-relieving nursing essence is composed of the following raw materials: myrobalan, paeonol, fructus cnidii, purslane, citral, eugenol, glycerol, seaweed extract, EDTA-2 sodium, 130w of sodium hyaluronate, polyglutamic acid, trehalose, polyglyceryl ether-26, biological polysaccharide gum-1, aminomethyl propanol, DSBC silanol salicylate, 1,3 butanediol and preservative.
Preferably, the dandruff removing and itching relieving nursing essence comprises the following raw materials in parts by weight: 1-5 parts of myrobalan, 0.1-0.5 part of paeonol, 1-5 parts of fructus cnidii, 1-5 parts of purslane, 0.01-0.05 part of citral, 0.01-0.05 part of eugenol, 20-30 parts of glycerol, 1-5 parts of seaweed extract, 0.1-0.5 part of EDTA-2 sodium, 1-5 parts of 130w sodium hyaluronate, 1-5 parts of polyglutamic acid, 1-5 parts of trehalose, -261-5 parts of polyglycerol ether, 11-5 parts of biological polysaccharide gum, 1-5 parts of aminomethyl propanol, 1-5 parts of DSBC salicylic acid silanol, 1-5 parts of 1, 3-butanediol and 0.1-0.5 part of preservative.
Preferably, the dandruff removing and itching relieving nursing essence comprises the following raw materials in parts by weight: 3 parts of myrobalan, 0.3 part of paeonol, 3 parts of fructus cnidii, 3 parts of purslane, 0.03 part of citral, 0.03 part of eugenol, 25 parts of glycerol, 3 parts of seaweed extract, 0.3 part of EDTA-2 sodium, 3 parts of 130w sodium hyaluronate, 3 parts of polyglutamic acid, 3 parts of trehalose, 263 parts of polyglycerol ether, 13 parts of biological polysaccharide gum, 3 parts of aminomethyl propanol, 3 parts of DSBC silanol salicylate, 3 parts of 1,3 butanediol and 0.3 part of preservative.
Preferably, the 1, 3-butanediol is diluted to a 3.0-6.0% concentration 1, 3-butanediol aqueous solution when used.
Preferably, the preservative is a composition of phenoxyethanol, ethylhexyl glycerol, methyl paraben and propyl paraben.
A production process of an anti-dandruff itching-relieving nursing essence comprises the following steps:
s1, cleaning and airing the myrobalan, the fructus cnidii and the purslane for later use;
s2, preparing a 1, 3-butanediol aqueous solution according to the proportion for later use;
s3, putting the prepared 1, 3-butanediol aqueous solution into an extraction kettle, and adding the prepared medicinal materials;
s4, heating to 60-65 ℃, extracting for 3-4 hours, and performing coarse filtration after extraction is finished;
s5, performing coarse filtration, then performing concentration filtration, performing sterilization treatment after the concentration filtration is finished, and then adding paeonol, citral, eugenol, seaweed extract, EDTA-2 sodium, 130w of sodium hyaluronate, polyglutamic acid and trehalose, and uniformly stirring for later use, wherein the material is material A;
s6, adding glycerol, polyglycerol ether-26, biopolysaccharide gum-1, aminomethyl propanol and DSBC silanol salicylate into a reaction kettle, heating to 95 ℃, keeping the temperature, stirring for 1 hour until the mixture is uniform, and counting as material B;
and S7, adding the material A into the material B, stirring uniformly, and then adding the preservative.
Preferably, in S1, the fabric is cleaned with an ultrasonic cleaning device and then naturally dried.
Preferably, in S5, the concentration and filtration are carried out by ultrafiltration technology, and the filtration particle size of the ultrafiltration membrane is 8-12 nm.
Preferably, in S5, the concentrated and filtered mixture is sterilized by radiation sterilization with a radiation dose of 5-8 kGy.
The application of the anti-dandruff itching-relieving nursing essence is applied to the fields of shampoo, hair conditioner washing and scalp nursing.
The invention has the beneficial effects that:
the dandruff-removing itching-relieving nursing essence is characterized in that by combining the thought of 'integration and syndrome differentiation' of the traditional Chinese medicine, the scalp is nourished and repaired through four ways of 'tonifying, clearing, fixing and nourishing', and the problem of dandruff-removing itching-relieving is solved; according to the formula principle of 'monarch, minister, assistant and guide', the function of 'dispelling wind and relieving itching' of the wild fennel is taken, the effects of astringing and inhibiting bacteria of the myrobalan are taken, the effects of clearing heat and cooling blood and relieving itching of the cortex moutan are taken, the anti-inflammatory and soothing effects of the purslane are obtained, and the optimal synergistic effect is realized by optimizing the formula proportion.
The anti-dandruff itching-relieving nursing essence has the following characteristics:
1. clearing away heat and toxic materials, inhibiting bacteria, and eliminating pathogenic bacteria and fungi growth on scalp surface;
2. nourishing blood, promoting blood circulation, dispelling pathogenic wind, relieving itching, relieving scalp itching, and enhancing scalp skin immunity;
3. repairing scalp barrier, regulating microbial flora, and preventing hair line retrogradation.
Detailed Description
The technical solutions in the embodiments of the present invention are clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1:
the anti-dandruff itching-relieving nursing essence comprises the following raw materials in parts by weight: 1 part of myrobalan, 0.5 part of paeonol, 1 part of fructus cnidii, 5 parts of purslane, 0.01 part of citral, 0.05 part of eugenol, 20 parts of glycerol, 5 parts of seaweed extract, 0.1 part of EDTA-2 sodium, 5 parts of 130w sodium hyaluronate, 1 part of polyglutamic acid, 5 parts of trehalose, 261 parts of polyglycerol ether, 15 parts of biological polysaccharide gum, 1 part of aminomethyl propanol, 5 parts of DSBC silanol salicylate, 1 part of 1, 3-butanediol and 0.5 part of preservative.
The dandruff-removing itching-relieving nursing essence prepared by the embodiment is applied to the field of shampoo.
Example 2:
the anti-dandruff itching-relieving nursing essence comprises the following raw materials in parts by weight: 3 parts of myrobalan, 0.3 part of paeonol, 3 parts of fructus cnidii, 3 parts of purslane, 0.03 part of citral, 0.03 part of eugenol, 25 parts of glycerol, 3 parts of seaweed extract, 0.3 part of EDTA-2 sodium, 3 parts of 130w sodium hyaluronate, 3 parts of polyglutamic acid, 3 parts of trehalose, 263 parts of polyglycerol ether, 13 parts of biological polysaccharide gum, 3 parts of aminomethyl propanol, 3 parts of DSBC silanol salicylate, 3 parts of 1,3 butanediol and 0.3 part of preservative.
The dandruff-removing itching-relieving nursing essence prepared by the embodiment is applied to the field of scalp nursing.
Example 3:
the anti-dandruff itching-relieving nursing essence comprises the following raw materials in parts by weight: 5 parts of myrobalan, 0.1 part of paeonol, 5 parts of fructus cnidii, 1 part of purslane, 0.05 part of citral, 0.01 part of eugenol, 30 parts of glycerol, 1 part of seaweed extract, 0.5 part of EDTA-2 sodium, 1 part of 130w sodium hyaluronate, 5 parts of polyglutamic acid, 1 part of trehalose, 265 parts of polyglycerol ether, 11 parts of biological polysaccharide gum, 5 parts of aminomethyl propanol, 1 part of DSBC silanol salicylate, 5 parts of 1, 3-butanediol and 0.1 part of preservative.
The dandruff-removing itching-relieving nursing essence prepared by the embodiment is applied to the field of hair conditioner washing and nursing.
The production process of the dandruff-removing itching-relieving nursing essence in the embodiment 1 to 3 comprises the following steps:
s1, cleaning and airing the myrobalan, the fructus cnidii and the purslane for later use;
s2, preparing a 1, 3-butanediol aqueous solution according to the proportion for later use;
s3, putting the prepared 1, 3-butanediol aqueous solution into an extraction kettle, and adding the prepared medicinal materials;
s4, heating to 65 ℃, extracting for 3 hours, and performing coarse filtration after extraction is finished;
s5, performing coarse filtration, then performing concentration filtration, performing sterilization treatment after the concentration filtration is finished, and then adding paeonol, citral, eugenol, seaweed extract, EDTA-2 sodium, 130w of sodium hyaluronate, polyglutamic acid and trehalose, and uniformly stirring for later use, wherein the material is material A;
s6, adding glycerol, polyglycerol ether-26, biopolysaccharide gum-1, aminomethyl propanol and DSBC silanol salicylate into a reaction kettle, heating to 95 ℃, keeping the temperature, stirring for 1 hour until the mixture is uniform, and counting as material B;
and S7, adding the material A into the material B, stirring uniformly, and then adding the preservative.
In the step S1, ultrasonic cleaning equipment is adopted for cleaning, and the cleaned product is naturally dried in the sun, so that ultrasonic cleaning is cleaner, and the impurity amount during extraction is reduced; in S5, performing concentration filtration by using an ultrafiltration technology, wherein the filtration particle size of an ultrafiltration membrane is 8-12 nm; and S5, sterilizing the concentrated and filtered mixture by adopting an irradiation sterilization technology, wherein the irradiation dose is 5-8kGy, and the performance of the product cannot be changed by irradiation sterilization.
Experimental example 1 in vitro experiment
Experiment for verifying in-vitro drug sensitivity of dandruff-removing itching-relieving nursing essence to limiting malassezia
Selecting fungi in a logarithmic growth phase, placing the fungi in a tissue homogenizer filled with a proper amount of physiological saline, fully grinding, counting by using a blood cell counting plate, then diluting a limited malassezia suspension by using a Dixon liquid culture medium, adjusting the concentration to be 1.0-1.2 × CFU/M L, during an experiment, carrying out a twofold dilution operation on the antidandruff antipruritic care essence (prepared in experiment example 2) in a 96-well plate, adding equal amounts of bacterial suspension into each well of a sample, setting a growth control hole and a blank control hole, placing the sample in an incubator at 32 ℃ for culturing for 5-6d, and carrying out visual observation, wherein the lowest medicine concentration of the no visible colony growth hole is used as an MIC value;
performing quality control during each measurement, wherein the quality control strain adopts candida parapsilosis, the quality control drug adopts ketoconazole, and under the parallel operation condition, after the quality control strain is in 48 hours, the MIC value is in the range of 0.12-0.5ug/ml, which is regarded as effective and credible of the measurement result; each strain was assayed in triplicate according to the above procedure and the arithmetic mean of MIC was calculated.
Results of the experiment
Anti-dandruff itching-relieving scalp nursing essence with effect of resisting malassezia californica in vitro (mu g/m L)
| Test drug | Dandruff-removing itching-relieving nursing essence | Zinc pyrithione (positive control group) |
| Restricted malassezia | 0.938±0.08ul/ml) | 1.031±0.17ug/ml |
The experimental result shows that the anti-restrictive malassezia activity of the anti-dandruff itching-relieving nursing essence is greater than 0.5 compared with that of the positive control group zinc pyrithione, and no significant difference exists. Further proving the effectiveness of the anti-dandruff itching-relieving nursing essence on the restrictive malassezia.
Example 2 animal experiments
Animal experiment verification experiment of dandruff removing, itching relieving and nursing essence on guinea pig skin itch caused by histamine phosphate
48 common-grade guinea pigs, half male and female, weighing about 300g, were divided into 4 groups at random according to body weight, namely, a model group (M), a blank matrix group (control), a positive drug zinc pyrithione group (P), and an antidandruff and antipruritic care essence group (QXE) (prepared in example 3). Applying a sample to the depilated area of the right hind paw of the guinea pig once a day, applying an equal amount of blank substrate to the blank substrate group, 100 ul/time continuously for 4 days, before the last administration, scratching the depilated area by using sterile gauze, applying the medicine again, starting to dropwise add 0.01% histamine phosphate (50 ul/body) at the wound surface 1h after the last application, dropwise adding 0.01%, 0.02%, 0.03%, 0.04% and 0.05% … … in sequence every 3min, increasing the dosage until the guinea pig licks the right hind paw, finally, when the guinea pig licks the right hind paw, taking the total amount of the histamine phosphate applied as an itching area, and observing and counting whether the itching areas among the groups have statistical difference.
The right hind paw foot licking action of the guinea pig can be obviously observed by dripping histamine phosphate into the right hind paw abrasion area of the guinea pig, which indicates that the establishment of a skin itch model of the guinea pig caused by the histamine phosphate is successful; compared with the blank matrix group, the anti-dandruff itching-relieving nursing essence group has significant difference.
Influence of the anti-dandruff antipruritic essence on the model of skin itch of guinea pigs caused by histamine phosphate (
±S)
The experimental result shows that the anti-itch effect of the anti-dandruff itching-relieving nursing essence is better than that of the positive control group zinc pyrithione.
EXAMPLE 3 safety test
The dandruff-removing and itching-relieving nursing essence prepared in examples 1 to 3 was subjected to irritation experiments with reference to technical specifications for cosmetic safety (2015 edition), and the irritation effect on the skin was examined.
Experimental verification
The prepared dandruff-removing itching-relieving nursing essence adopts a chick embryo experiment and a human body patch experiment which are common drug irritation experiment methods, and detailed steps are not described.
The experimental results prove that: the anti-dandruff itching-relieving nursing essence is safe and non-irritant to skin.
In the description herein, references to the description of "one embodiment," "an example," "a specific example" or the like are intended to mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, the schematic representations of the terms used above do not necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.
Finally, it should be noted that the above-mentioned preferred embodiments of the present invention are provided merely to help illustrate the present invention. The preferred embodiments are not intended to be exhaustive or to limit the invention to the precise embodiments disclosed. Obviously, many modifications and variations are possible in light of the above teaching. The embodiments were chosen and described in order to best explain the principles of the invention and the practical application, to thereby enable others skilled in the art to best utilize the invention. The invention is limited only by the claims and their full scope and equivalents.
Claims (9)
1. The anti-dandruff itching-relieving nursing essence is characterized by comprising the following raw materials: myrobalan, paeonol, fructus cnidii, purslane, citral, eugenol, glycerol, seaweed extract, EDTA-2 sodium, 130w of sodium hyaluronate, polyglutamic acid, trehalose, polyglyceryl ether-26, biological polysaccharide gum-1, aminomethyl propanol, DSBC silanol salicylate, 1,3 butanediol and preservative.
2. The essence of claim 1, which is characterized by comprising the following raw materials in parts by weight: 1-5 parts of myrobalan, 0.1-0.5 part of paeonol, 1-5 parts of fructus cnidii, 1-5 parts of purslane, 0.01-0.05 part of citral, 0.01-0.05 part of eugenol, 20-30 parts of glycerol, 1-5 parts of seaweed extract, 0.1-0.5 part of EDTA-2 sodium, 1-5 parts of 130w sodium hyaluronate, 1-5 parts of polyglutamic acid, 1-5 parts of trehalose, -261-5 parts of polyglycerol ether, 11-5 parts of biological polysaccharide gum, 1-5 parts of aminomethyl propanol, 1-5 parts of DSBC salicylic acid silanol, 1-5 parts of 1, 3-butanediol and 0.1-0.5 part of preservative.
3. The essence of claim 2, which is characterized by comprising the following raw materials in parts by weight: 3 parts of myrobalan, 0.3 part of paeonol, 3 parts of fructus cnidii, 3 parts of purslane, 0.03 part of citral, 0.03 part of eugenol, 25 parts of glycerol, 3 parts of seaweed extract, 0.3 part of EDTA-2 sodium, 3 parts of 130w sodium hyaluronate, 3 parts of polyglutamic acid, 3 parts of trehalose, 263 parts of polyglycerol ether, 13 parts of biological polysaccharide gum, 3 parts of aminomethyl propanol, 3 parts of DSBC silanol salicylate, 3 parts of 1,3 butanediol and 0.3 part of preservative.
4. The essence of claim 1, wherein the 1, 3-butanediol is diluted to 3.0-6.0% concentration in 1, 3-butanediol aqueous solution.
5. The essence of claim 1, wherein the preservative is a combination of phenoxyethanol, ethylhexyl glycerin, methyl paraben and propyl paraben.
6. The production process of the essence for removing dandruff, relieving itching and caring according to any one of claims 1 to 5, characterized by comprising the following steps:
s1, cleaning and airing the myrobalan, the fructus cnidii and the purslane for later use;
s2, preparing a 1, 3-butanediol aqueous solution according to the proportion for later use;
s3, putting the prepared 1, 3-butanediol aqueous solution into an extraction kettle, and adding the prepared medicinal materials;
s4, heating to 60-65 ℃, extracting for 3-4 hours, and performing coarse filtration after extraction is finished;
s5, performing coarse filtration, then performing concentration filtration, performing sterilization treatment after the concentration filtration is finished, and then adding paeonol, citral, eugenol, seaweed extract, EDTA-2 sodium, 130w of sodium hyaluronate, polyglutamic acid and trehalose, and uniformly stirring for later use, wherein the material is material A;
s6, adding glycerol, polyglycerol ether-26, biopolysaccharide gum-1, aminomethyl propanol and DSBC silanol salicylate into a reaction kettle, heating to 95 ℃, keeping the temperature, stirring for 1 hour until the mixture is uniform, and counting as material B;
and S7, adding the material A into the material B, stirring uniformly, and then adding the preservative.
7. The production process of the essence for dandruff removal, itching relieving and nursing according to claim 6, wherein in S5, the concentration and filtration are carried out by using ultrafiltration technology, and the filtration particle size of the ultrafiltration membrane is 8-12 nm.
8. The production process of the essence for dandruff removal, itching relieving and nursing according to claim 6, wherein in S5, the concentrated and filtered mixture is sterilized by irradiation sterilization technology, and the irradiation dose is 5-8 kGy.
9. The use of the essence according to any one of claims 1 to 5, wherein the essence is used in the fields of shampoo, conditioner rinse and scalp care.
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Application publication date: 20200717 |