CN101559035A - Plant extract composition for killing fungi, preparation method thereof and application in preparing antifungal products - Google Patents
Plant extract composition for killing fungi, preparation method thereof and application in preparing antifungal products Download PDFInfo
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- CN101559035A CN101559035A CNA2009100960679A CN200910096067A CN101559035A CN 101559035 A CN101559035 A CN 101559035A CN A2009100960679 A CNA2009100960679 A CN A2009100960679A CN 200910096067 A CN200910096067 A CN 200910096067A CN 101559035 A CN101559035 A CN 101559035A
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Abstract
The invention relates to a plant extract composition, a preparation method thereof and application of the plant extract composition in preparing the antifungal products. The composition comprises one or more components of matrine extract, scutelloside extract, berberine hydrochloride extract, agrimophol extract, caffeic acid extract and asiaticosid extract. The antifungal products comprise antidandruff shampoo, mouth cleaning products, female sanitary products, itching-relieving shower bath and antifungal medicaments. The invention also relates to an antifungal product using the composition.
Description
Technical field
The present invention relates to a kind of composition of plant extracts, its preparation method and be used to prepare the purposes of antifungal products, described antifungal products for example anti-dandruff shampoo water, dental care products, feminine hygiene articles, itching-relieving shower reveals and antifungal drug.The invention still further relates to antifungal products that uses above-mentioned composition and preparation method thereof.
Background technology
At present, antibiotics has been used to tackle the harm that antibacterial brings, and tackles the also not effective especially means of mycete.Some mycete makes moldy metamorphisms such as medicated clothing, timber, food, also have some to bring disease to people, can make the people infect, cause genital diseases, oral ulcer such as Candida albicans, the infection of chlosma can cause the various skin disease, as psoriasis, the dandruff, alopecia etc.
Candida albicans is a kind of metatroph, survive at ordinary times in skin, mucosa, digestive tract and other internal organs of human body, because antibiotic and immunosuppressant extensive use clinically, dysbacteriosis takes place or when Abwehrkraft des Koepers reduces, Candida albicans will be bred, when reaching a certain amount of, human body will be fallen ill.Oral candidiasis (oralcandidiasis) is a fungus---the caused disease of cari oris mucosa of candida infection, and Candida albicans is topmost pathogen.Wherein thrush is modal oral candidiasis.Genital candidiasis is the phallic disease of a kind of common men and women, is the genital diseases that is caused by candida albicans infection, propagates easily in the women, causes leucorrhoea grow in quantity, symptoms such as pudendal pruritus.Since primary disease can trafficability characteristic life propagate, so world's health organization is listed it among sexually transmitted disease (STD) in.At present, the treatment of candidiasis is many based on the antifungal drug treatment, and clinical commonly used drug has antibiotic such as miconazole, clotrimazole, ketoconazole.
Dandruff is a skin chunk dead on the scalp, is to produce in the natural metabolism process of scalp cells.Studies show that the quantity of the generation of the dandruff and scurf pityrosporum furfur (chlosma) has direct relation.When the quantity of chlosma was in normal range, the keratinization of skin of head epidermis cell also was in the normal metabolic process.But when the breeding of chlosma increased unusually, the accretion rate of skin of head epidermis cell was obviously accelerated, thereby formed dandruff.Chlosma is a kind of strong fungus of fat of having a liking for, and mainly survives in the horny layer and hair follicle at seborrhea position, human body skin surface, comprises skin of head.Its existence makes that the content of saturated fatty acid reduces greatly in the sebum layer, thereby has accelerated cuticular agingly and come off and form dandruff, and causes capital pruritus.Though dandruff is non-fatal disease too much, have a strong impact on attractive in appearance and social communication.Comprehensive foreign literature report, the anti-dandruff raw material that is widely used at present mainly contains Zinc Undecylenate, Zinc Pyrithione (ZPT), octopirox (OCT), ketoconazole, climbazole etc.
Application number is the Chinese medicine preparation that 200580000666.6 Chinese invention patent application discloses a kind of anti-dandruff, clear scalp pomade, contain the Radix Angelicae Dahuricae, Flos Chrysanthemi, Fructus Viticis, Radix Sophorae Flavescentis etc., can be made into anti-dandruff liquid or shampoo or hair conditioner, antipruritic, dandruff, the wet goods effect of decaptitating are arranged, the effect of hair care, hair care, black hair is arranged again.The shortcoming of this application is that its product effect is relatively poor.
Application number is that 200410045002.9 Chinese invention patent application discloses a kind of medicaments nursing shampoo, it is characterized in that comprising the herbal raw material by Cacumen Platycladi, Folium Pini, Rhizoma Gastrodiae, Fructus Ligustri Lucidi, Rhizoma Chuanxiong, Herba Ecliptae, Fructus Mori, Herba Spirodelae, Herba Pogostemonis, Flos Caryophylli, edible oil, Radix Et Rhizoma Rhei proportioning.This invention select for use can dispel the wind moisturize, medical herbs is a raw material among the nourishing blood and promoting blood circulation, hair growth promoting, black hair, removing scurf and relieving itching, control poliosis, alopecia, make by adding other adjuvant, can effectively activate the metabolism of hairline cell, impel the benign cycle of head blood, hair is comprehensively nursed, removing scurf and relieving itching is effective, has no side effect.The shortcoming of this application is that the product use cost is higher, and the denseer taste of Chinese medicine of band.
Application number is that 03150713.1 Chinese invention patent application discloses a kind of antiinflammatory antibacterial medicines compositions and preparation method.This pharmaceutical composition is the external preparation of forming with active component that contains decolored aloe gel oxymatrine, fibrauretin and Borneolum Syntheticum and pharmaceutic adjuvant.Described compositions has strong antibacterial and sterilizing function, and escherichia coli, staphylococcus aureus, Candida albicans are all had strong antibacterial and bactericidal action, and product gentleness, nontoxic non-stimulated is applicable to daily pudendum nursing of women and hand skin cleaning sterilization.The shortcoming of this application is that the product use cost is higher.
Summary of the invention
In sum, the product of prior art exists that effect is relatively poor, cost is too high and shortcoming such as taste of Chinese medicine is overweight.The inventor finds, the composition of plant extracts of the application of the invention, the product that obtains is easy to use, unit cost is cheap, and bactericidal effect is good, particularly at the fungus that causes dandruff and initiation gynaecopathia very strong killing action is arranged, suitable with similar effects of antibiotics, have no side effect, no taste of Chinese medicine, thus solved above-mentioned prior art problems.
The present invention relates to a kind of composition of plant extracts, said composition comprises and is selected from one or more following components: matrine extract, baicalin extract, berberine hydrochloride extract, agrimophol extract, caffeic acid extract, asiaticoside extract.Said composition has bactericidal action, particularly can effectively kill fungus when low concentration, and is effective especially to Candida albicans, chlosma, nontoxic non-stimulated.
The matrine extract can derive from Radix Sophorae Flavescentis, Herba Sophorae alopecuroidis, Radix Sophorae Tonkinensis etc.Matrine content preferred 5～95% in the said extracted thing.Extracting method is summarized as follows: being example with the Radix Sophorae Flavescentis, is solvent with the second alcohol and water, 1: 10 in proportion～10: 1 mixed, Radix Sophorae Flavescentis and the solvent bath raio by 1: 5～1: 40 is fed intake, and heat tracing extracts, and filters and collects filtrate, filtrate is concentrated into finite concentration, the dry powder that gets.
The baicalin extract can derive from labiate Radix Scutellariae etc.Content of baicalin preferred 20～99% in the said extracted thing, extracting method is summarized as follows: Radix Scutellariae and water are fed intake according to 1: 5～1: 40 bath raio, regulate pH value, heat tracing extracts, filtering and concentrating is regulated pH value and is stirred sedimentation to certain solid content, leaves standstill 12 hours, filter and clean filtering residue to certain pH value, drying is beaten powder promptly.
The berberine hydrochloride extract can derive from the dry bark of plant Rhizoma Coptidis, Cortex Phellodendri etc., Berberidaceae plant Radix Berberidis root bark or rutaceae wampee, Cortex Phellodendri etc.Content of berberine hydrochloride preferred 20～99.5% in the said extracted thing.Extracting method is summarized as follows: with the second alcohol and water was solvent, and 1: 10 in proportion～10: 1 mixed feeds intake Rhizoma Coptidis, Cortex Phellodendri and solvent according to 1: 1: 5～1: 1: 40 bath raio, heat tracing extracts, filter and collect filtrate, filtrate is concentrated into finite concentration, the dry powder that gets.
The agrimophol extract can derive from the hibernaculum of Rosaceae herbaceos perennial Agrimony.Agrimophol content preferred 20～85% in the said extracted thing.Extracting method is summarized as follows: with the second alcohol and water is solvent, and 1: 10 in proportion～10: 1 mixed feeds intake Radix Agrimoniae and the solvent bath raio by 1: 5～1: 40, and heat tracing extracts, and filters and collects filtrate, and filtrate is concentrated into finite concentration, dry powder.
The caffeic acid extract can derive from feverfew Herba Solidaginis or Herba Taraxaci herb, rosaceous plant Fructus Pyri Pashiae fruit, the sapindaceous plant aalii, ranunculaceae plant Rhizoma Cimicifugae rhizome, the Eurasian Rhizoma Polypodiodis Nipponicae rhizome of Polypodiaceae plant, rutaceae Fructus Citri Limoniae peel, polygonaceae plant herb, the Valerianaceae plant radix valerianae, labiate Herba thymi vulgaris herb or Eucommiaceae plant Folium Eucommiae etc.Caffeic acid content preferred 1～95% in the said extracted thing.Extracting method is summarized as follows: be example with the Herba Taraxaci, Herba Taraxaci and water are fed intake by 1: 5～1: 40 bath raio that heat tracing extracts, filter and collect filtrate that filtrate is concentrated into finite concentration, and spray drying gets powder.
The asiaticoside extract can derive from Herba Centellae, Herba Lysimachiae, Radix Tripterygii Wilfordii etc.Asiaticoside content preferred 2～99% in the said extracted thing.Extracting method is summarized as follows: being example with the Herba Centellae, is solvent with the second alcohol and water, 1: 10 in proportion～10: 1 mixed, Herba Centellae and the solvent bath raio by 1: 5～1: 40 is fed intake, and heat tracing extracts, and filters and collects filtrate, filtrate is concentrated into finite concentration, the dry powder that gets.
Above-mentioned composition of plant extracts can further comprise additive, 0～40 part of sodium alkyl sulfate for example, and wherein the carbochain of aliphatic alcohol is C12～C14, is applicable to common daily chemical products, trade name is K12, and how tame manufacturer is arranged both at home and abroad; 0～40 part of fatty alcohol ether sodium sulphate, it is a raw material with C12～C14 aliphatic alcohol, and the oxirane adduct number is 1～5, and trade name is AES, SLES or AES.How tame manufacturer is arranged both at home and abroad.Above-mentioned additive is well known by persons skilled in the art.
Plant extract compositions of the present invention is by mixing above-mentioned plant extract preparation, mixing quality percentage ratio is: the matrine extract: 0.1～70 part, baicalin extract: 0.5～80 part, berberine hydrochloride extract: 1～75 part, agrimophol extract: 0～60 part, the caffeic acid extract: 0～80 part, asiaticoside extract: 0～30 part.
The invention further relates to the above-mentioned purposes that composition of plant extracts is used to prepare antifungal products that is used for.Above-mentioned antifungal products comprises that for example anti-dandruff shampoo water, dental care products, feminine hygiene articles, itching-relieving shower reveal and antifungal drug.The prescription of this antifungal products is well known by persons skilled in the art except that composition of plant extracts of the present invention.The amount of composition of plant extracts of the present invention in antifungal products of the present invention can be 0.05%～2% in mass, preferred 0.1%～2%, further preferred 0.2%～1%.
The invention still further relates to above-mentioned antifungal products.
Above-mentioned composition of plant extracts can use known method to add antifungal products by those skilled in the art, uses very convenient.For example, can above-mentioned composition of plant extracts be sneaked into, wherein proportionally add in the high-speed solid mixer successively raw materials used by simple blended method, 10～65 ℃ of whipping temps, mixing time 30～120 minutes, this moment, product was a yellow powder, granularity 60～200 orders.
Antifungal products of the present invention can be by obtaining in other components that above-mentioned composition of plant extracts added this product, also can add by each component with above-mentioned composition of plant extracts in other components of this product to obtain.In other words, each component that both can at first prepare composition of plant extracts of the present invention among the present invention, prepare composition of plant extracts of the present invention then thus, further preparation contains the antifungal products of above-mentioned composition, each component that also can at first prepare composition of plant extracts of the present invention, directly prepare thus then and contain the antifungal products of above-mentioned composition, and do not need the step of independent preparation composition of plant extracts of the present invention.It will be understood by those skilled in the art that above-mentioned two kinds of methods are equivalent with regard to final antifungal products.
Relatively with present antifungal products, main advantage of the present invention is: all primary raw materials are plant extract, it is natural to draw materials, this product is very remarkable to the bacteriostasis and sterilization effect of fungus, effect and antibiotic are approximate, and consumption is few, and unit cost is low, safety is without any side effects, easy to use.
Embodiment
Prescription 1: antifungal preparation
In 200L solid mixer, add matrine extract: 10.5kg successively, baicalin extract: 32kg, berberine hydrochloride extract: 7.5kg, agrimophol extract: 2.2kg, caffeic acid extract: 6.8kg, asiaticoside extract: 3.3kg, fatty alcohol-ether sodium sulfate: 20kg, 60 ℃ of stirrings obtained yellow powder, pH value 6.32 in 90 minutes.This mixture bactericidal activity detection method and result are as follows: (mg/L)
One, the activation of strain.
The standard strain is put into constant incubator, cultivated 18 hours down for 37 ℃.
Two, the check of bacterial activity.
To the sterilization plate that contains corresponding culture medium, every ware inoculation one ring was cultivated 24 hours down, is observed plate and find to have the colony growth that meets corresponding fungus characteristic for 37 ℃ with the standard bacterial classification inoculation.
Three, the preparation of mixture gradient solution
Get the 0.1g mixture, be mixed with 0.01% aqueous solution (100ppm) with the sterilized water dissolving, divide three groups by test strain class, draw 10ml and add pipe each No. 1, draw 5ml from No. 1 pipe then and add pipe No. 2, add next test tube to doubly drawing successively,, 2 to No. 6 pipes are added sterilized water to 5ml up to No. 7 pipes.
Four, inoculated and cultured
Get standard bacterium liquid one ring with inoculating loop and add each pipe, cultivate down for 37 ℃ and observed in 24 hours.
Five, MIC interpretation of result
Get the test tube range estimation of cultivating, not having obvious muddiness is asepsis growth, and this concentration is MIC concentration.
The product 0.01～0.2% that this prescription is formed is applicable to candidiasiss such as women's cleaning supplies, dental care products.
Prescription 2: women's cleaning solution prescription
Prescription 3: dandruff removing agent
In 200L solid mixer, add matrine extract: 1.5kg successively, baicalin extract: 25kg, berberine hydrochloride extract: 29.2kg, asiaticoside extract: 0.9kg, sodium lauryl sulphate 30kg, 60 ℃ of stirrings obtained yellow powder, pH value 6.01 in 90 minutes.This mixture bactericidal activity is as follows: (mg/L)
| Staphylococcus aureus | Escherichia coli | Bacillus pyocyaneus | Candida albicans | Chlosma | |
| Minimum inhibitory concentration | 1280 | 1280 | 2560 | 80 | 10 |
The product 0.1～0.5% that this prescription is formed is applicable to anti-dandruff shampoo water, itching-relieving shower liquid etc.
Prescription 4: anti-dandruff shampoo water prescription
Trial effect
Crowd's age on probation: 18～56 years old
Hair puzzlement: dandruff, head pruritus, scalp pomade
Number on probation: 50 people, wherein male: 36 people, women: 14 people
The hair washing cycle: 3 days once; Time on probation: 1 month
Hair washing method: use a shampoo, massage 15 minutes afterflush
| Result on trial | Male (people) | Women (people) | Total number of persons (people) | Percentage ratio |
| Very dissatisfied (not anti-dandruff, not antipruritic, do not deoil) | 1 | 1 | 2 | 4％ |
| Be not very satisfied, can only accept reluctantly (with after dandruff, head pruritus, scalp pomade are arranged again soon) | 4 | 1 | 5 | 10％ |
| Satisfied (can keep not having dandruff, head pruritus, scalp pomade in 3 days) | 28 | 12 | 40 | 80％ |
| Be satisfied with very much (improve dandruff, scalp pomade, head pruritus symptom, and can cure gradually) | 3 | 0 | 3 | 6％ |
Claims (7)
1, a kind of composition of plant extracts, said composition comprise and are selected from one or more following components: matrine extract, baicalin extract, berberine hydrochloride extract, agrimophol extract, caffeic acid extract, asiaticoside extract.
2, the composition of plant extracts of claim 1, wherein said component ratio are 3～40 parts of 0.1～70 part of matrine extract, 0.5～80 part of baicalin extract, 1～75 part of berberine hydrochloride extract, 0～60 part of agrimophol extract, 0～80 part of caffeic acid extract, 0～30 part of asiaticoside extract, C12～0～40 part of C14 sodium alkyl sulfate and C12～C14 fatty alcohol-ether sodium sulfate in mass.
3, the method for preparing the composition of plant extracts of claim 1 or 2 comprises the component of described composition of plant extracts is mixed.
4, the purposes of claim 1 or 2 composition of plant extracts is used to prepare antifungal products.
5, a kind of antifungal products, wherein comprise 3～40 parts of 0.1～70 part of matrine extract, 0.5～80 part of baicalin extract, 1～75 part of berberine hydrochloride extract, 0～60 part of agrimophol extract, 0～80 part of caffeic acid extract, 0～30 part of asiaticoside extract, C12～0～40 part of C14 sodium alkyl sulfate and C12～C14 fatty alcohol-ether sodium sulfate, above component is 0.05%～2% at the total consumption in final products.
6, the antifungal products of claim 5, its form are anti-dandruff shampoo water, dental care products, feminine hygiene articles, itching-relieving shower dew or antifungal drug.
7, prepare the method for the antifungal products of claim 5 or 6, wherein each component or the above-mentioned plant extract with above-mentioned composition of plant extracts mixes with other components of described antifungal products.
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| CN101559035B CN101559035B (en) | 2011-05-04 |
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Cited By (5)
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| CN103432012A (en) * | 2013-09-09 | 2013-12-11 | 北京振东光明药物研究院有限公司 | Sophocarpidine micro emulsion as well as preparation method thereof and application of micro emulsion in liquid soap |
| CN103976907A (en) * | 2014-05-29 | 2014-08-13 | 暨南大学 | Cosmetic comprising composition with slow anti-allergic action as well as preparation method and application thereof |
| CN104434691A (en) * | 2014-12-12 | 2015-03-25 | 安徽新华学院 | Natural anti-dandruff effervescent granule or effervescent tablet and preparation method thereof |
| CN104287996B (en) * | 2013-07-15 | 2018-02-16 | 江西普正制药有限公司 | A kind of bark of eucommia shampoo and preparation method thereof |
| CN114028292A (en) * | 2021-12-06 | 2022-02-11 | 广州市发歌精细化工有限公司 | Shampoo containing plant composite anti-dandruff agent and preparation method thereof |
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2009
- 2009-02-09 CN CN2009100960679A patent/CN101559035B/en not_active Expired - Fee Related
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104287996B (en) * | 2013-07-15 | 2018-02-16 | 江西普正制药有限公司 | A kind of bark of eucommia shampoo and preparation method thereof |
| CN103432012A (en) * | 2013-09-09 | 2013-12-11 | 北京振东光明药物研究院有限公司 | Sophocarpidine micro emulsion as well as preparation method thereof and application of micro emulsion in liquid soap |
| CN103976907A (en) * | 2014-05-29 | 2014-08-13 | 暨南大学 | Cosmetic comprising composition with slow anti-allergic action as well as preparation method and application thereof |
| CN103976907B (en) * | 2014-05-29 | 2017-04-05 | 暨南大学 | A kind of cosmetics comprising the compositionss with antiallergic effect of releiving, its preparation method and application |
| CN104434691A (en) * | 2014-12-12 | 2015-03-25 | 安徽新华学院 | Natural anti-dandruff effervescent granule or effervescent tablet and preparation method thereof |
| CN114028292A (en) * | 2021-12-06 | 2022-02-11 | 广州市发歌精细化工有限公司 | Shampoo containing plant composite anti-dandruff agent and preparation method thereof |
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| CN101559035B (en) | 2011-05-04 |
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Address after: 310011 Huayuan cultural and creative park, No. 555, Concord Road, Zhejiang, Hangzhou, Gongshu District A207 Patentee after: Fang Jiajian Address before: 310019 No. 7, old Hangzhou Road, Hangzhou, Zhejiang, Jianggan District Patentee before: Fang Jiajian |
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Granted publication date: 20110504 Termination date: 20180209 |