A kind of cleaning skin care compositions and preparation method
Technical field
The invention belongs to the Chinese medicine for external application field, be specifically related to a kind of natural composition that cleans maintenance nursing skin, mucosa and preparation method thereof.
Background technology
Along with the deterioration of environment, the outburst of various diseases, people are more and more higher to the requirement of health, require all article of environment of living in and use not only to want clean, especially pathogenic bacterium can not be arranged.Except environmental health, Personal hygiene requires higher, and various antibacterial fancy soap bath gel collutorys and so on are tinkling of jades meeting the eye on every side already, and various privates care products are also come out one after another simultaneously.
Make a general survey of all external preparation for skin products, all have claim the bacteriostasis antibiosis person, its main component is nothing more than chemical drugs and Chinese and western drugses such as chlorhexidine (being hibitane), triclosan (i.e. 2,4,4 '-three chloro-2 '-dihydroxy diphenyl ethers), benzalkonium bromide, metronidazole, Radix Sophorae Flavescentis, Fructus Cnidiis.As everyone knows, " being three fens poison of medicine ", society all advocates environmental protection now, and people are uphold nature, and are natural pollution-free, namely mean health.
Summary of the invention
The weak point that exists at the existing composition of medicine similar to the present invention, purpose of the present invention aims to provide the natural composition of a kind of cleaning-nursing skin, mucosa, compositions by this pure natural, provide a kind of safe antibacterial cleaning product to people, the antibiotic cleaning that can be used for body surface skin and mucosa, as hair washing, clean, gargle, take a shower, bathe foot, dandruff, acne, oral ulcer, halitosis, pudendal pruritus/abnormal flavour, tinea manus and pedis and other various dermatopathies are all had alleviate and preventive effect.
Another object of the present invention is to provide the preparation method of the natural composition of this cleaning-nursing skin mucosa.
In order to achieve the above object, the present invention has adopted following technical scheme:
The natural composition of a kind of cleaning-nursing skin, mucosa is formed by following feedstock production by weight:
Semen sojae atricolor 1-28 part, Fructus Sapindi Mukouossi 50-320 part.
Above-mentioned two kinds of raw materials add following ingredients after extracting:
Plants essential oil 1-10 part, Oleum Cocois 50-230 part, glycerol 20-300 part.
Optimum, above-mentioned cleaning-nursing skin, the natural composition of mucosa, each composition weight proportioning is:
10 parts of Semen sojae atricolor, 80 parts of Fructus Sapindi Mukouossis, 3 parts of plants essential oils, 120 parts of Oleum Cocois, 50 parts of glycerol.
Said components of the present invention and pharmaceutically acceptable carrier are made gel, lotion, spray, suppository, effervescent tablet, liniment.
The present invention also can be applicable to prepare shampoo, cleansing milk, bath gel etc.
The method of the natural composition of preparation cleaning-nursing skin, mucosa, its preparation methods steps is as follows:
1. the preparation of soybean extraction liquid:
A. Semen sojae atricolor after 20-30 hour, is broken into the mud shape with the pure water of 2-3 times of weight dipping;
B. will be broken into the Semen sojae atricolor of mud shape by extraction tower mixing, isolated by filtration, obtain white emulsion;
C. add 4 times of pure water of Semen sojae atricolor weight in the white emulsion, add volume ratio 0.1%-0.5% chitosan then, isolated by filtration obtains transparent soybean extraction liquid after concentrating;
2. the preparation of Fructus Sapindi Mukouossi extracting solution:
Get peel of Fructus Sapindi Mukouossi and pulverize, soaked 2 hours with its 3 times amount purified water, boiled 2 hours, filter, get filtrate for later use;
3. press described formula ratio with soybean extraction liquid and Fructus Sapindi Mukouossi extract mixing, get the mixed liquor I;
4. press formula ratio plants essential oil is mixed with non-ionic surfactant polyoxyethylene castor oil hydrogenated, polyoxyethylene castor oil, alkylphenol polyoxyethylene or tween 1-30 part, stir, slowly add in the mixed liquor I then, get the mixture II;
5. by formula ratio Oleum Cocois, glycerol are mixed to evenly, add in the mixture II, add water stir compositions.
In the prescription of the present invention:
Soybean extraction liquid is colourless transparent liquid, can be directly water-soluble, and overcome hibitane and triclosan etc. and must be dissolved in after the ethanol just water-soluble shortcoming earlier, reduced the zest of product to skin and mucosa.Soybean extraction liquid all has good inactivating efficacy to bacterial strains such as Candida albicans, coliform, pneumobacillus, legionella, mycete, tinea alba bacterium, green pus bacterium.Soybean extraction liquid is as medical material, be widely used in gynaecologic washing lotion, medical supplies, sanitary towel, wet tissue, cosmetics, oral hygiene, anthelmintic, medicated napkin, home-use gas defence articles for use, water purification, vegetable (eating usefulness raw) disinfectant solution etc. various antibiotic, smelly, sterilization field disappears.Its high-quality of nationality, safety efficiently, has the characteristics of cost performance, is just extensively paid close attention to, and progressively replaces hibitane, and traditional antibiosis and sterilization agent such as triclosan belongs to the top standard in the world, domestic like product.
Fructus Sapindi Mukouossi, peel contain saponin (Saponin), vitamin C, tyrosine (Tyrosine), glycine (Glycine), alanine (Alanine), Folium Symplocoris Caudatae, fructose, glucose, pentose, methylpentose, arabic gum, rhamnose.Environmental protection, nuisanceless.Its extracting solution foam is abundant, effectively takes out stains, and antibiotic beauty treatment, tender skin, brightens speckle, acne removing, prevents and treats dermatosis.The pure natural product, 100% high-fall solution, life-time service can not produce any to human body and the harmful residue of environment.Be conducive to health, be conducive to environmental conservation.
Plants essential oil is extraction plant specific aromatic substance, is taken from herbal flower, leaf, root, bark, fruit, seed, resin etc. and extract with distillation, squeezing mode.Plants essential oil is called liquid golden again, and it has following effect: one, purify air and sterilize: because quintessence oil has antibiotic antiseptical composition, so that it has is antibiotic, antimicrobial and antiviral characteristic.Two, provide cytotrophy: because quintessence oil contains hormone, vitamin, antibiotic, so can furnish us with soma nutrition.Three, balance body and mind spirit: the most important speciality of quintessence oil is abnormal smells from the patient, and it can influence the limbic system of brain, acts in the olfactory sensation, and small aromatic molecules more can cause the reaction of psychology and physiology different levels at nervus centralis.Four, immunologic function: wherein most important characteristic is the immune system that volatile oil helps to strengthen health, helps the attack of the various pathogenic bacterias of opposing, virus.Five, has natural anticorrosion speciality.
Oleum Cocois is the endosperm of Petiolus Trachycarpi kind of plant Cortex cocois radicis, through pulverizing the oil that squeezes after baking is steamed, is white in color or faint yellow fat.Contain free fatty in the oil, caproic acid, Palmic acid, caprylic acid, Stearic Acid, capric acid, oleic acid, lauric acid contains stigmastatrienol in the sterol of Oleum Cocois, stigmasterol and 24-ethylidenecholest-5-en-3.beta.-ol., hitodesterol and sterol, cupreol.Tool is controlled scabies, chilblain, the effect of skin or hair care.
Raw material environmental protection of the present invention, technology is simple, bacteriostasis is powerful (bacteriostasis rate is up to more than 90%), but action temperature and, non-stimulated to skin and mucosa.
The test example
(1) fungistatic effect
1, according to GB15979-2002, this sample is under experimental condition, and stock solution acts on 2min to escherichia coli, and average bacteriostasis rate is 100%.
To colibacillary fungistatic effect
The average clump count of positive controls and scope: 6.47 * 104(4.90 * 104~7.70 * 104) cfu/ml
The negative control asepsis growth.
Conclusion: this sample stock solution has strong bacteriostasis to escherichia coli.
2, according to GB15979-2002, this sample stock solution under experimental condition acts on 2min to staphylococcus aureus, and average bacteriostasis rate is 100%.
The fungistatic effect of staphylococcus aureus
The average clump count of positive controls and scope: 6.47 * 104(4.90 * 104~7.70 * 104) cfu/ml
The negative control asepsis growth.
Conclusion: this sample stock solution has strong bacteriostasis to staphylococcus aureus.
3, according to GB15979-2002, this sample is under experimental condition, and stock solution is to Candida albicans effect 10min, and average bacteriostasis rate is 93.14%.
Fungistatic effect to Candida albicans
The average clump count of positive controls and scope: 6.47 * 104(4.90 * 104~7.70 * 104) cfu/ml
The negative control asepsis growth.
Conclusion: this sample stock solution has strong bacteriostasis to Candida albicans.
(2) irritant experiment
Sample is to rabbit vagina mucosa irritation result of the test
Remarks: every section integration=epithelium+leukocyte infiltration+congestion of blood vessel+edema; Every average integral=(A section integration+B section integration+C section integration)/3; Scoring=(No. 2 animal average integral+, No. 1 animal average integral+No. 3 animal average integral)/3; Stimulation index=experimental group average integral-matched group average integral.
Conclusion: this sample is nonirritant to rabbit vagina mucosa irritation result of the test.
The specific embodiment
Embodiment 1
1. the preparation of soybean extraction liquid:
A. the 10g Semen sojae atricolor after 25 hours, is broken into the mud shape with the pure water of 2.5 times of weight dipping;
B. will be broken into the Semen sojae atricolor of mud shape by extraction tower mixing, isolated by filtration, obtain white emulsion;
C. add 4 times of pure water of Semen sojae atricolor weight in the white emulsion, add the chitosan of volume ratio 0.5% then, isolated by filtration obtains transparent soybean extraction liquid after concentrating.
2. the preparation of Fructus Sapindi Mukouossi extracting solution:
Get the 80g peel of Fructus Sapindi Mukouossi and pulverize, soaked 2 hours with its 3 times amount purified water, boiled 2 hours, filter, get filtrate for later use;
3. with soybean extraction liquid and Fructus Sapindi Mukouossi extract mixing, get the mixed liquor I;
4. plants essential oil 3g is mixed with polyoxyethylene hydrogenated Oleum Ricini 1g, stir, slowly add in the mixed liquor I then, get the mixture II;
5. Oleum Cocois 120g, glycerol 50 are mixed to evenly, add in the mixture II, add water stir compositions.
Embodiment 2
1. the preparation of soybean extraction liquid:
A. Semen sojae atricolor 1g after 20 hours, is broken into the mud shape with the pure water of 2 times of weight dipping;
B. will be broken into the Semen sojae atricolor of mud shape by extraction tower mixing, isolated by filtration, obtain white emulsion;
C. add 4 times of pure water of Semen sojae atricolor weight in the white emulsion, add the chitosan of volume ratio 0.1% then, isolated by filtration obtains transparent Semen sojae atricolor and extracts thick liquid after concentrating.
2. the preparation of Fructus Sapindi Mukouossi extracting solution:
Get the 50g peel of Fructus Sapindi Mukouossi and pulverize, soaked 2 hours with its 3 times amount purified water, boiled 2 hours, filter, get filtrate for later use;
3. with soybean extraction liquid and Fructus Sapindi Mukouossi extract mixing, get the mixed liquor I;
4. plants essential oil 1g is mixed with alkylphenol polyoxyethylene 3g, stir, slowly add in the mixed liquor I then, get the mixture II;
5. Oleum Cocois 50g, glycerol 20g are mixed to evenly, add in the mixture II, add water stir compositions.
Embodiment 3
1. the preparation of soybean extraction liquid:
A. the 28g Semen sojae atricolor after 30 hours, is broken into the mud shape with the pure water of 3 times of weight dipping;
B. will be broken into the Semen sojae atricolor of mud shape by extraction tower mixing, isolated by filtration, obtain white emulsion;
C. add 4 times of pure water of Semen sojae atricolor weight in the white emulsion, add volume ratio 0.3% chitosan then, isolated by filtration obtains transparent Semen sojae atricolor and extracts thick liquid after concentrating.
2. the preparation of Fructus Sapindi Mukouossi extracting solution:
Get the 320g peel of Fructus Sapindi Mukouossi and pulverize, soaked 2 hours with its 3 times amount purified water, boiled 2 hours, filter, get filtrate for later use;
3. with soybean extraction liquid and Fructus Sapindi Mukouossi extract mixing, get the mixed liquor I;
4. plants essential oil 10g is mixed with polyoxyethylene castor oil 10g, stir, slowly add in the mixed liquor I then, get the mixture II;
5. Oleum Cocois 230g, glycerol 300g are mixed to evenly, add in the mixture II, add water stir compositions.
Embodiment 4
1. the preparation of soybean extraction liquid:
A. the 20g Semen sojae atricolor after 20 hours, is broken into the mud shape with the pure water of 2 times of weight dipping;
B. will be broken into the Semen sojae atricolor of mud shape by extraction tower mixing, isolated by filtration, obtain white emulsion;
C. add 4 times of pure water of Semen sojae atricolor weight in the white emulsion, add the chitosan of volume ratio 0.2% then, isolated by filtration obtains transparent Semen sojae atricolor and extracts thick liquid after concentrating.
2. the preparation of Fructus Sapindi Mukouossi extracting solution:
Get the 120g peel of Fructus Sapindi Mukouossi and pulverize, soaked 2 hours with its 3 times amount purified water, boiled 2 hours, filter, get filtrate for later use;
3. with soybean extraction liquid and Fructus Sapindi Mukouossi extract mixing, get the mixed liquor I;
4. plants essential oil 8g is mixed with tween 10g, stir, slowly add in the mixed liquor I then, get the mixture II;
5. Oleum Cocois 170g, glycerol 150g are mixed to evenly, add in the mixture II, add water stir compositions.
Embodiment 5
1. the preparation of soybean extraction liquid:
A. the 15g Semen sojae atricolor after 30 hours, is broken into the mud shape with the pure water of 3 times of weight dipping;
B. will be broken into the Semen sojae atricolor of mud shape by extraction tower mixing, isolated by filtration, obtain white emulsion;
C. add 4 times of pure water of Semen sojae atricolor weight in the white emulsion, add the chitosan of volume ratio 0.4% then, isolated by filtration obtains transparent Semen sojae atricolor and extracts thick liquid after concentrating.
2. the preparation of Fructus Sapindi Mukouossi extracting solution:
Get the 60g peel of Fructus Sapindi Mukouossi and pulverize, soaked 2 hours with its 3 times amount purified water, boiled 2 hours, filter, get filtrate for later use;
3. with soybean extraction liquid and Fructus Sapindi Mukouossi extract mixing, get the mixed liquor I;
4. plants essential oil 2g is mixed with non-ionic surface active agent, stir, slowly add in the mixed liquor I then, get the mixture II;
5. Oleum Cocois 55g, glycerol 75g are mixed to evenly, add in the mixture II, add water stir compositions.
Embodiment 6
1. the preparation of soybean extraction liquid:
A. the 25g Semen sojae atricolor after 30 hours, is broken into the mud shape with the pure water of 3 times of weight dipping;
B. will be broken into the Semen sojae atricolor of mud shape by extraction tower mixing, isolated by filtration, obtain white emulsion;
C. add 4 times of pure water of Semen sojae atricolor weight in the white emulsion, add volume ratio 0.25% chitosan then, isolated by filtration obtains transparent Semen sojae atricolor and extracts thick liquid after concentrating.
2. the preparation of Fructus Sapindi Mukouossi extracting solution:
Get the 90g peel of Fructus Sapindi Mukouossi and pulverize, soaked 2 hours with its 3 times amount purified water, boiled 2 hours, filter, get filtrate for later use;
3. with soybean extraction liquid and Fructus Sapindi Mukouossi extract mixing, get the mixed liquor I;
4. plants essential oil 5g is mixed with non-ionic surface active agent, stir, slowly add in the mixed liquor I then, get the mixture II;
5. Oleum Cocois 90g, glycerol 120g are mixed to evenly, add in the mixture II, add water stir compositions.
Embodiment 7
1. the preparation of soybean extraction liquid:
A. the 3g Semen sojae atricolor after 30 hours, is broken into the mud shape with the pure water of 3 times of weight dipping;
B. will be broken into the Semen sojae atricolor of mud shape by extraction tower mixing, isolated by filtration, obtain white emulsion;
C. add 4 times of pure water of Semen sojae atricolor weight in the white emulsion, add the chitosan of volume ratio 0.3% then, isolated by filtration obtains transparent Semen sojae atricolor and extracts thick liquid after concentrating.
2. the preparation of Fructus Sapindi Mukouossi extracting solution:
Get the 65g peel of Fructus Sapindi Mukouossi and pulverize, soaked 2 hours with its 3 times amount purified water, boiled 2 hours, filter, get filtrate for later use;
3. with soybean extraction liquid and Fructus Sapindi Mukouossi extract mixing, get the mixed liquor I;
4. plants essential oil 5g is mixed with polyoxyethylene hydrogenated Oleum Ricini 5g, stir, slowly add in the mixed liquor I then, get the mixture II;
5. Oleum Cocois 58g, glycerol 50 are mixed to evenly, add in the mixture II, add water stir compositions.