CN102258725B - Sophora alopecuroide vagina cleaning bacteriostatic lotion and preparation method thereof - Google Patents
Sophora alopecuroide vagina cleaning bacteriostatic lotion and preparation method thereof Download PDFInfo
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Abstract
The invention relates to sophora alopecuroide vagina cleaning bacteriostatic lotion and a preparation method thereof. The sophora alopecuroide vagina cleaning bacteriostatic lotion comprises the following components such as phellodendron bark, golden larch bark, sargentgloryvine stem, radix scutellariae, rhubarb, radix stemonae, angelica, Sichuan pepper, icy mint, borneol, Tween-80, glycerol, sophora alopecuroide, distilled water and ethanol. The sophora alopecuroide vagina cleaning bacteriostatic lotion follows the traditional formula principle, and has main functions of clearing away heat and toxic materials and inhibiting bacteria and diminishing inflammation as well as eliminating dampness and relieving itching, activating blood circulation to dissipate blood stasis, removing slough and promoting tissue regeneration and effectively inhibiting growth and reproduction of monilia albicans, staphylococcus aureus and escherichia coli; and meanwhile the sophora alopecuroide vagina cleaning bacteriostatic lotion has the advantages of sophisticated materials selected, exquisite preparation process and no adverse side effects.
Description
Technical field
The present invention relates to a kind of Herba Sophorae alopecuroidis vagina cleaning bacteriostasis washing liquid and preparation method thereof.
Background technology
Vaginitis is puzzlement women's common gynecological disease, frequently-occurring disease, and severe patient can influence patient's study, work and life.In order to be suitable for modern times rhythm of life fast, often forget to eat and sleep in the busy work of people, overtired, make health be in sub-health state for a long time, cause body immunity to descend, add antibacterial and grow wantonly, depressed rage impairing the liver, turbid damp pents up, the multiple abscess part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels is violated and pudendum, or because occupying wetland for a long time, experience damp, or health preserving is careless, ignores health, causes vaginitis to become common, the multiple disease of gynecological.
Many Chinese medicine washing liquids are arranged in the market, but great majority are many based on the bitter cold medicine in the composition based on eliminating evil, thereby only immediate effect can occur, its effect is not lasting, cures the symptoms, not the disease, easily recurrence.Too much bitter cold medicine also can make the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels become cold more empty, violates ring in appearance or in fact, and resistance descends more.
Summary of the invention
The purpose of this invention is to provide a kind of Herba Sophorae alopecuroidis vagina cleaning bacteriostasis washing liquid and preparation method thereof, serve as that main holding concurrently can dampness removing to stop itchin be blood circulation promoting and blood stasis dispelling with heat-clearing and toxic substances removing, inhibiting bacteria and diminishing inflammation, can change saprophytic new again, and can effectively suppress Candida albicans, staphylococcus aureus, escherichia coli growth and breeding, and to adopt nontoxic Chinese herbal medicine be main material production.
The solvent of Herba Sophorae alopecuroidis vagina cleaning bacteriostasis washing liquid provided by the invention is the mixed liquor of water and ethanol, described Herba Sophorae alopecuroidis vagina cleaning bacteriostasis washing liquid comprises following constituent: the water extract of these six kinds of medical materials of Cortex Phellodendri, Cortex Pseudolaricis, Caulis Sargentodoxae, Radix Scutellariae, Radix Et Rhizoma Rhei and the Radix Stemonae, the ethanol extraction of Herba Sophorae alopecuroidis, Radix Angelicae Sinensis and Pericarpium Zanthoxyli add volatile oil and the filtrate that distilled water extraction obtains, Mentholum, Borneolum Syntheticum, glycerol, tween 80 in volatile oil extractor.
Preferably, the consumption of the raw material of the described Herba Sophorae alopecuroidis vagina cleaning bacteriostasis of per 4000～6000ml washing liquid is as follows: Cortex Phellodendri 35～55g, Cortex Pseudolaricis 20～40g, Caulis Sargentodoxae 50～70g, Radix Scutellariae 35～55g, Radix Et Rhizoma Rhei 25～45g, the Radix Stemonae 30～50g, Herba Sophorae alopecuroidis 35～55g, Radix Angelicae Sinensis 38～58g, Pericarpium Zanthoxyli 35～55g, Mentholum 2～4g, Borneolum Syntheticum 2～4g, glycerol 85～115g, tween 80 55～85g, ethanol 200～3000ml.
More preferably, the consumption of the raw material of the described Herba Sophorae alopecuroidis vagina cleaning bacteriostasis of every 5000ml washing liquid is as follows: Cortex Phellodendri 40～50g, Cortex Pseudolaricis 25～35g, Caulis Sargentodoxae 55～65g, Radix Scutellariae 4～50g, Radix Et Rhizoma Rhei 30～40g, the Radix Stemonae 35～45g, Herba Sophorae alopecuroidis 40～50g, Radix Angelicae Sinensis 45～55g, Pericarpium Zanthoxyli 40～50g, Mentholum 2～4g, Borneolum Syntheticum 2～4g, glycerol 90～110g, tween 80 55～70g,, ethanol 500～2000ml.
The preparation method of Herba Sophorae alopecuroidis vagina cleaning bacteriostasis washing liquid provided by the invention may further comprise the steps:
Step 1, to extract in Cortex Phellodendri 35～55 weight portions, Cortex Pseudolaricis 20～40 weight portions, Caulis Sargentodoxae 50～70 weight portions, Radix Scutellariae 35～55 weight portions, Radix Et Rhizoma Rhei 25～45 weight portions, the Radix Stemonae 30～50 weight portions mixing adding extraction pot, get extracting solution, concentrating density then is 1.05-1.1g/ml;
Step 2, to put into the reflux, extract, device after Herba Sophorae alopecuroidis 35～55 weight portions adding soak with ethanol, reflux, extract,, filtrate is left and taken in filtration, to stir in the final liquid that obtains of this filtrate adding step 1, precipitate with ethanol filters then, recovered alcohol adds distilled water again and precipitates, filters and leave and take filtrate in the filtrate;
Step 3, Radix Angelicae Sinensis 45～55 weight portions, Pericarpium Zanthoxyli 40～50 weight portions are utilized distilled water extraction in volatile oil extractor, the volatile oil that must mix, with the extracting liq of Radix Angelicae Sinensis and Pericarpium Zanthoxyli filter, simmer down to density is liquid, the precipitate with ethanol of 1.05-1.1g/ml, filter, recovered alcohol gets filtrate, this filtrate is joined in the filtrate that step 2 finally obtains, stir;
Step 4, with Mentholum 2～4 weight portions, Borneolum Syntheticum 2～4 weight portion dissolve with ethanols, wrap up the volatile oil of described mixing with 85～115 weight portion glycerol, 55～85 weight portion tween 80s then and with Borneolum Syntheticum, the Mentholum of dissolve with ethanol, it is joined in the final liquid that obtains of step 3, stir evenly, filter and namely get described Herba Sophorae alopecuroidis vagina cleaning bacteriostasis washing liquid.
Wherein, the consumption of the raw material of using in each step is preferably: Cortex Phellodendri 40～50 weight portions, Cortex Pseudolaricis 25～35 weight portions, Caulis Sargentodoxae 55～65 weight portions, Radix Scutellariae 4～50 weight portions, Radix Et Rhizoma Rhei 30～40 weight portions, the Radix Stemonae 35～45 weight portions, Herba Sophorae alopecuroidis 40～50 weight portions, Radix Angelicae Sinensis 45～55 weight portions, Pericarpium Zanthoxyli 40～50 weight portions, Mentholum 2～4 weight portions, Borneolum Syntheticum 2～4 weight portions, glycerol 90～110 weight portions, tween 80 55～70 weight portions.
Preferably, in the step 1, described extracting solution is merged by extracted twice and gets, and adds the distilled water of 8-14 times of weight when extracting, each 1-2 hour at every turn.
Preferably, the concrete operations flow process of step 2 is: Herba Sophorae alopecuroidis is added put into the reflux, extract, device after 8-14 times of soak with ethanol 1-3 hour, reflux, extract, 14-18 hour, filtrate is left and taken in filtration, will this filtrate add in the final liquid that obtains of step 1 and stir, precipitate with ethanol makes the liquid alcohol degree reach 50～65 degree then, after 12-36 hour, filter, recovered alcohol adds distilled water again and precipitates 12-36 hour, filters and leave and take filtrate in the filtrate.
Preferably, the concrete operations flow process of step 3 is: join Radix Angelicae Sinensis, Pericarpium Zanthoxyli in the volatile oil extractor respectively, each adds 6-10 times of weight distilled water extraction, extracts 6-10 hour, collects and mixes two kinds of volatile oil, extracting liq merging filtration, the simmer down to density of above-mentioned Radix Angelicae Sinensis and Pericarpium Zanthoxyli are liquid, the precipitate with ethanol of 1.05-1.1g/ml and make the liquid alcohol degree reach 50～65 degree, filter, recovered alcohol gets filtrate, this filtrate is joined in the liquid that step 2 finally obtains, stir.
Preferably, in the step 4, the ethanol of dissolving Mentholum, Borneolum Syntheticum is the ethanol of 95 weight % of 10～30 weight portions.
Preferably, described Cortex Phellodendri, Cortex Pseudolaricis, Caulis Sargentodoxae, Radix Scutellariae, Radix Et Rhizoma Rhei, the Radix Stemonae, Herba Sophorae alopecuroidis, Radix Angelicae Sinensis and Pericarpium Zanthoxyli are 8～12 purpose coarse powder.
Herba Sophorae alopecuroidis vagina cleaning bacteriostasis washing liquid provided by the invention and preparation method thereof has following advantage:
1, effect is obvious.Herba Sophorae alopecuroidis vagina cleaning bacteriostasis washing liquid of the present invention is followed traditional combination principle, effectively the growth and breeding of intravaginal staphylococcus aureus, escherichia coli, Candida albicans.
2, raw material is fastidious.Herba Sophorae alopecuroidis vagina cleaning bacteriostasis washing liquid of the present invention is followed traditional combination principle, chooses genuine medical material meticulously, has guaranteed quality and the effect of Herba Sophorae alopecuroidis vagina cleaning bacteriostasis washing liquid.
3, preparation technology is superior.Invention Herba Sophorae alopecuroidis vagina cleaning bacteriostasis washing liquid of the present invention passes on and develops traditional Technology, and links such as formula compatibility, medical material selection, Chinese medicine processing are kept on improving especially, make that the therapeutic effect of invention Herba Sophorae alopecuroidis vagina cleaning bacteriostasis washing liquid is remarkable, and do not have bad side effect.
Description of drawings
Fig. 1 is the preparation method flow chart of Herba Sophorae alopecuroidis vagina cleaning bacteriostasis washing liquid of the present invention.
The specific embodiment
In the Herba Sophorae alopecuroidis vagina cleaning bacteriostasis washing liquid provided by the invention, monarch drug is selected Cortex Phellodendri, Radix Et Rhizoma Rhei, Radix Scutellariae for use, and wherein Cortex Phellodendri has heat clearing and damp drying, and pathogenic fire purging is except steaming, and the effect of skin ulcer is treated in detoxifcation; Radix Et Rhizoma Rhei has the effect of attacking stagnant, clearing away damp-heat, pathogenic fire purging, removing heat from blood, blood stasis dispelling, detoxifcation; Radix Scutellariae has the hot dampness that disappears, the effect of eliminating fire and detoxication.Ministerial drug is selected Radix Angelicae Sinensis, Caulis Sargentodoxae for use, and wherein Radix Angelicae Sinensis is enriched blood and invigorated blood circulation, the effect of menstruction regulating and pain relieving; Caulis Sargentodoxae has promoting blood circulation to remove obstruction in the collateral, the effect of the dissipating blood stasis that relieves internal heat, wind dispelling insecticide.Adjuvant drug is selected Cortex Pseudolaricis, Pericarpium Zanthoxyli, the Radix Stemonae, Herba Sophorae alopecuroidis for use, and Cortex Pseudolaricis has parasite killing, antipruritic effect; Pericarpium Zanthoxyli has the effect of fragrant stomach invigorating, warming spleen and stomach for dispelling cold, removing damp and stopping pain, parasite killing detoxifcation, antipruritic solution raw meat; The Radix Stemonae has the effect of antibiotic parasite killing treatment pudendum Pruritus; Herba Sophorae alopecuroidis has heat clearing and damp drying, pain relieving, the effect of parasite killing.Messenger drug is selected Herba Menthae, Borneolum Syntheticum for use, Herba Menthae dispelling wind wherein, heat radiation, ward off dirty, detoxifcation; The Borneolum Syntheticum refreshment of having one's ideas straightened out, clearing away heat to alleviate pain.
Herba Sophorae alopecuroidis vagina cleaning bacteriostasis washing liquid of the present invention is followed traditional combination principle, serve as that main holding concurrently can dampness removing to stop itchin be blood circulation promoting and blood stasis dispelling with heat-clearing and toxic substances removing, inhibiting bacteria and diminishing inflammation, can change saprophytic newly again, and can effectively suppress the effect of Candida albicans, staphylococcus aureus, escherichia coli growth and breeding.And there is not bad side effect.
Fig. 1 is the preparation method flow chart of Herba Sophorae alopecuroidis vagina cleaning bacteriostasis washing liquid of the present invention.Mainly comprise following four steps:
Step 1 is mixed the Cortex Phellodendri after cleaning, Cortex Pseudolaricis, Caulis Sargentodoxae, Radix Scutellariae, Radix Et Rhizoma Rhei, six kinds of medical materials of the Radix Stemonae, 10 purpose coarse powder in the adding extraction pot, adds the distilled water of 8-14 times of weight, extract twice, each 1-2 hour, merge extracted twice liquid, concentrating density then is 1.05-1.1g/ml.
Step 2 adds 8-14 times with Herba Sophorae alopecuroidis remove impurity, 10 purpose coarse powder and puts into the reflux, extract, device after soak with ethanol 1-3 hour, reflux, extract, 14-18 hour, filters and leaves and takes filtrate.This filtrate added in the liquid that step 1 obtains stir, precipitate with ethanol makes the liquid alcohol degree reach 60 degree then, and after 12-36 hour, filter, recovered alcohol adds distilled water again and precipitates 12-36 hour, filters and leave and take filtrate in the filtrate.
Step 3,10 order coarse powder of Radix Angelicae Sinensis, Pericarpium Zanthoxyli are joined respectively in the volatile oil extractor, and each adds 6-10 times of weight distilled water extraction, extracts 6-10 hour, collect and mix two kinds of volatile oil, extracting liq merging filtration, the simmer down to density of above-mentioned Radix Angelicae Sinensis and Pericarpium Zanthoxyli are liquid, the precipitate with ethanol of 1.05-1.1g/ml and make the liquid alcohol degree reach 60 °, filter recovered alcohol, get filtrate, this filtrate is joined in the liquid that step 2 obtains, stir
Step 4, Mentholum, Borneolum Syntheticum added in the liquid with 95% alcoholic solution dissolve, the volatile oil that Radix Angelicae Sinensis, Pericarpium Zanthoxyli is mixed with glycerol, tween 80 parcel and with in the Borneolum Syntheticum of 95% dissolve with ethanol, the Mentholum joins it in liquid of step 3 acquisition then, stirs evenly, filters namely.
Below by embodiment the preparation method of Herba Sophorae alopecuroidis vagina cleaning bacteriostasis washing liquid of the present invention is described further, and describes in conjunction with the result of use of Comparative Examples to the Herba Sophorae alopecuroidis vagina cleaning bacteriostasis washing liquid that obtains.
Embodiment 1
Step 1, Cortex Phellodendri 35g after cleaning, Cortex Pseudolaricis 40g, Caulis Sargentodoxae 70g, Radix Scutellariae 35g, six kinds of medical materials of Radix Et Rhizoma Rhei 25g, Radix Stemonae 40g, 10 purpose coarse powder are mixed in the adding extraction pot, the distilled water that adds 12 times of weight, extract twice, each 1 hour, merge extracted twice liquid, concentrating density then is 1.07g/ml.
Step 2 adds 8.5 times of soak with ethanol with Herba Sophorae alopecuroidis 35g remove impurity, 10 purpose coarse powder and puts into the reflux, extract, device after 1.4 hours, and reflux, extract, 13 hours is filtered and left and taken filtrate.This filtrate added in the liquid that step 1 obtains stir, precipitate with ethanol makes the liquid alcohol degree reach 60 degree then, and after 14 hours, filter, recovered alcohol adds distilled water again and precipitates 14 hours, filters and leave and take filtrate in the filtrate.
Step 3, join the 10 order coarse powder of Radix Angelicae Sinensis 48g, Pericarpium Zanthoxyli 45g in the volatile oil extractor respectively, each adds 7 times of weight distilled water extraction, extracts 9 hours, collects and mixes two kinds of volatile oil, extracting liq merging filtration, the simmer down to density of above-mentioned Radix Angelicae Sinensis and Pericarpium Zanthoxyli are liquid, the precipitate with ethanol of 1.07g/ml and make the liquid alcohol degree reach 60 °, filter, recovered alcohol gets filtrate, this filtrate is joined in the liquid that step 2 obtains, stir.
Step 4, Mentholum 2g, Borneolum Syntheticum 2g are dissolved with 95% (mass concentration) ethanol 100ml, the volatile oil that mixes with glycerol 105g, tween 80 80g parcel Radix Angelicae Sinensis, Pericarpium Zanthoxyli and with Borneolum Syntheticum, the Mentholum of 95% dissolve with ethanol then, join in the lump then in the liquid of step 3 acquisition, stir evenly, filter namely.
Embodiment 2
Step 1, Cortex Phellodendri 45g after cleaning, Cortex Pseudolaricis 20g, Caulis Sargentodoxae 50g, Radix Scutellariae 55g, six kinds of medical materials of Radix Et Rhizoma Rhei 35g, Radix Stemonae 50g, 10 purpose coarse powder are mixed in the adding extraction pot, the distilled water that adds 13 times of weight, extract twice, each 1.3 hours, merge extracted twice liquid, concentrating density then is 1.06g/ml.
Step 2 adds 9 times of soak with ethanol with Herba Sophorae alopecuroidis 44g remove impurity, 10 purpose coarse powder and puts into the reflux, extract, device after 1.5 hours, and reflux, extract, 13 hours is filtered and left and taken filtrate.This filtrate added in the liquid that step 1 obtains stir, precipitate with ethanol makes the liquid alcohol degree reach 60 degree then, and after 13 hours, filter, recovered alcohol adds distilled water again and precipitates 13 hours, filters and leave and take filtrate in the filtrate.
Step 3, join the 10 order coarse powder of Radix Angelicae Sinensis 48g, Pericarpium Zanthoxyli 45g in the volatile oil extractor respectively, each adds 9 times of weight distilled water extraction, extracts 9 hours, collects and mixes two kinds of volatile oil, extracting liq merging filtration, the simmer down to density of above-mentioned Radix Angelicae Sinensis and Pericarpium Zanthoxyli are liquid, the precipitate with ethanol of 1.06g/ml and make the liquid alcohol degree reach 60 °, filter, recovered alcohol gets filtrate, this filtrate is joined in the liquid that step 2 obtains, stir.
Step 4, Mentholum 2g, Borneolum Syntheticum 2g added in the liquid with 95% alcoholic solution dissolve, the volatile oil that Radix Angelicae Sinensis, Pericarpium Zanthoxyli is mixed with glycerol 90g, tween 80 80g parcel and with in the Borneolum Syntheticum of 95% dissolve with ethanol, the Mentholum then, it is joined in the liquid of step 3 acquisition, stir evenly, filter namely.
Embodiment 3
Step 1, Cortex Phellodendri 40g after cleaning, Cortex Pseudolaricis 40g, Caulis Sargentodoxae 60g, Radix Scutellariae 45g, six kinds of medical materials of Radix Et Rhizoma Rhei 45g, Radix Stemonae 30g, 10 purpose coarse powder are mixed in the adding extraction pot, the distilled water that adds 8 times of weight, extract twice, each 1.1 hours, merge extracted twice liquid, concentrating density then is 1.08g/ml.
Step 2 adds 11 times of soak with ethanol with Herba Sophorae alopecuroidis 55g remove impurity, 10 purpose coarse powder and puts into the reflux, extract, device after 2.5 hours, and reflux, extract, 16 hours is filtered and left and taken filtrate.This filtrate added in the liquid that step 1 obtains stir, precipitate with ethanol makes the liquid alcohol degree reach 60 degree then, and after 20 hours, filter, recovered alcohol adds distilled water again and precipitates 20 hours, filters and leave and take filtrate in the filtrate.
Step 3, join the 10 order coarse powder of Radix Angelicae Sinensis 50g, Pericarpium Zanthoxyli 50g in the volatile oil extractor respectively, each adds 6 times of weight distilled water extraction, extracts 6 hours, collects and mixes two kinds of volatile oil, extracting liq merging filtration, the simmer down to density of above-mentioned Radix Angelicae Sinensis and Pericarpium Zanthoxyli are liquid, the precipitate with ethanol of 1.08g/ml and make the liquid alcohol degree reach 60 °, filter, recovered alcohol gets filtrate, this filtrate is joined in the liquid that step 2 obtains, stir.
Step 4, Mentholum 3g, Borneolum Syntheticum 3g added in the liquid with 95% alcoholic solution dissolve, the volatile oil that Radix Angelicae Sinensis, Pericarpium Zanthoxyli is mixed with glycerol 85g, tween 80 85g parcel and with in the Borneolum Syntheticum of 95% dissolve with ethanol, the Mentholum then, it is joined in the liquid of step 3 acquisition, stir evenly, filter namely.
Embodiment 4
Step 1, Cortex Phellodendri 44g after cleaning, Cortex Pseudolaricis 30g, Caulis Sargentodoxae 55g, Radix Scutellariae 40g, six kinds of medical materials of Radix Et Rhizoma Rhei 30g, Radix Stemonae 45g, 10 purpose coarse powder are mixed in the adding extraction pot, the distilled water that adds 8 times of weight, extract twice, each 1.1 hours, merge extracted twice liquid, concentrating density then is 1.08g/ml.
Step 2 adds 14 times of soak with ethanol with Herba Sophorae alopecuroidis 53g remove impurity, 10 purpose coarse powder and puts into the reflux, extract, device after 2 hours, and reflux, extract, 15 hours is filtered and left and taken filtrate.This filtrate added in the liquid that step 1 obtains stir, precipitate with ethanol makes the liquid alcohol degree reach 60 degree then, and after 17 hours, filter, recovered alcohol adds distilled water again and precipitates 17 hours, filters and leave and take filtrate in the filtrate.
Step 3, join the 10 order coarse powder of Radix Angelicae Sinensis 50g, Pericarpium Zanthoxyli 50g in the volatile oil extractor respectively, each adds 7 times of weight distilled water extraction, extracts 7 hours, collects and mixes two kinds of volatile oil, extracting liq merging filtration, the simmer down to density of above-mentioned Radix Angelicae Sinensis and Pericarpium Zanthoxyli are liquid, the precipitate with ethanol of 1.09g/ml and make the liquid alcohol degree reach 60 °, filter, recovered alcohol gets filtrate, this filtrate is joined in the liquid that step 2 obtains, stir.
Step 4, Mentholum 3g, Borneolum Syntheticum 3g added in the liquid with 95% alcoholic solution dissolve, the volatile oil that Radix Angelicae Sinensis, Pericarpium Zanthoxyli is mixed with glycerol 110g, tween 80 70g parcel and with in the Borneolum Syntheticum of 95% dissolve with ethanol, the Mentholum then, it is joined in the liquid of step 3 acquisition, stir evenly, filter namely.
Embodiment 5
Step 1, Cortex Phellodendri 45g after cleaning, Cortex Pseudolaricis 40g, Caulis Sargentodoxae 60g, Radix Scutellariae 35g, six kinds of medical materials of Radix Et Rhizoma Rhei 25g, Radix Stemonae 50g, 10 purpose coarse powder are mixed in the adding extraction pot, the distilled water that adds 12 times of weight, extract twice, each 1.7 hours, merge extracted twice liquid, concentrating density then is 1.08g/ml.
Step 2 adds 11 times of soak with ethanol with Herba Sophorae alopecuroidis 50g remove impurity, 10 purpose coarse powder and puts into the reflux, extract, device after 2.3 hours, and reflux, extract, 15 hours is filtered and left and taken filtrate.This filtrate added in the liquid that step 1 obtains stir, precipitate with ethanol makes the liquid alcohol degree reach 60 degree then, and after 16 hours, filter, recovered alcohol adds distilled water again and precipitates 16 hours, filters and leave and take filtrate in the filtrate.
Step 3, join the 10 order coarse powder of Radix Angelicae Sinensis 48g, Pericarpium Zanthoxyli 35g in the volatile oil extractor respectively, each adds 9 times of weight distilled water extraction, extracts 7 hours, collects and mixes two kinds of volatile oil, extracting liq merging filtration, the simmer down to density of above-mentioned Radix Angelicae Sinensis and Pericarpium Zanthoxyli are liquid, the precipitate with ethanol of 1.08g/ml and make the liquid alcohol degree reach 60 °, filter, recovered alcohol gets filtrate, this filtrate is joined in the liquid that step 2 obtains, stir.
Step 4, Mentholum 4g, Borneolum Syntheticum 4g added in the liquid with 95% alcoholic solution dissolve, the volatile oil that Radix Angelicae Sinensis, Pericarpium Zanthoxyli is mixed with glycerol 107g, tween 80 75g parcel and with in the Borneolum Syntheticum of 95% dissolve with ethanol, the Mentholum then, it is joined in the liquid of step 3 acquisition, stir evenly, filter namely.
Embodiment 6
Step 1, Cortex Phellodendri 45g after cleaning, Cortex Pseudolaricis 30g, Caulis Sargentodoxae 60g, Radix Scutellariae 45g, six kinds of medical materials of Radix Et Rhizoma Rhei 35g, Radix Stemonae 40g, 10 purpose coarse powder are mixed in the adding extraction pot, the distilled water that adds 12 times of weight, extract twice, each 1.5 hours, merge extracted twice liquid, concentrating density then is 1.05g/ml.
Step 2 adds 12 times of soak with ethanol with Herba Sophorae alopecuroidis 45g remove impurity, 10 purpose coarse powder and puts into the reflux, extract, device after 2 hours, and reflux, extract, 16 hours is filtered and left and taken filtrate.This filtrate added in the liquid that step 1 obtains stir, precipitate with ethanol makes the liquid alcohol degree reach 60 degree then, and after 24 hours, filter, recovered alcohol adds distilled water again and precipitates 24 hours, filters and leave and take filtrate in the filtrate.
Step 3, join the 10 order coarse powder of Radix Angelicae Sinensis 48g, Pericarpium Zanthoxyli 45g in the volatile oil extractor respectively, each adds 8 times of weight distilled water extraction, extracts 8 hours, collects and mixes two kinds of volatile oil, extracting liq merging filtration, the simmer down to density of above-mentioned Radix Angelicae Sinensis and Pericarpium Zanthoxyli are liquid, the precipitate with ethanol of 1.05g/ml and make the liquid alcohol degree reach 60 °, filter, recovered alcohol gets filtrate, this filtrate is joined in the liquid that step 2 obtains, stir.
Step 4, Mentholum 3g, Borneolum Syntheticum 3g are dissolved with 95% ethanol 100ml, the volatile oil that mixes with glycerol 100g, tween 80 60g parcel Radix Angelicae Sinensis, Pericarpium Zanthoxyli and with Borneolum Syntheticum, the Mentholum of 95% dissolve with ethanol joins it in liquid of step 3 acquisition then, stirs evenly, filters namely.
Related concocting method, supplementary product consumption, the rule of operation of the Chinese medicine medicinal material processing of above embodiment all carried out according to the regulation of 2010 editions Pharmacopoeias of the People's Republic of China " Chinese crude drug process of preparing Chinese medicine general rule "; The medical material that the Pharmacopoeia of the People's Republic of China does not record is carried out according to " Inner Mongol Chinese crude drug concocted specification ".
The Comparative Examples publication number is the preparation of the disclosed bacteriostasis pudendum-cleaning lotion of patent application of CN101444576A
(1) medical material Cortex Phellodendri 12kg, Cortex Fraxini 6kg, Flos Chrysanthemi Indici 18kg, Fructus Cnidii 7.5kg, Fructus Zanthoxyli 40kg, Radix Angelicae Sinensis 10kg, Herba Violae 10kg, the Fructus Forsythiae 7.5kg mixed powder after will cleaning is broken into coarse powder, water reflux secondary, heat for the first time the water of 8 times of weight, extracted 2 hours, the water extraction 1.5 hours that adds for the second time 6 times of weight, merge extracted twice liquid, obtain medicinal liquid A, stand-by;
(2) adding ethanol in A, is to contain the alcohol amount to reach 80%, leaves standstill 48 hours after-filtration, and filtrate recycling ethanol is received clean, gets medical liquid B;
(3) with Herba Sophorae alopecuroidis total alkali liquid heating in water bath, be condensed into flowing soaking paste, this process Herba Sophorae alopecuroidis total alkali content is constant, just organic solvent in total alkali liquor is driven away, dwindles the volume of total alkali liquor;
(4) total alkali extractum is joined in the medical liquid B, stir, leave standstill 48 hours after-filtration, get medicinal liquid C;
(5) with Borneolum Syntheticum, Herba Menthae 95% dissolve with ethanol, slowly join among the medicinal liquid C, the limit edged stirs, and stirring gets product.Eight kinds of medical materials that contain in the finished product in the step 1 are total to 81kg, Herba Sophorae alopecuroidis total alkali extractum 10kg, Borneolum Syntheticum 4.5kg, 95% ethanol 12kg.
The following describes the bacteriostatic experiment effect of three kinds of products that above-described embodiment 1～6 and Comparative Examples obtain.
One, staphylococcus aureus bacteriostatic experiment
(1) material:
1, test strain: in the 6th generation of staphylococcus aureus (ATCC6538), grinding institute by military medical courses in general institute stream provides.
2. disinfectant: be respectively the antibacterial liquid that embodiment 1～6 and Comparative Examples make
3. culture medium: nutrient broth, Nutrient agar
4. diluent (PBS)
(2) method:
1, test basis: " disinfection technology standard " 2002 editions 2.1.11.3.2 items
2, test is stock solution with disinfectant
3, experimental temperature is 19～22 ℃, and experiment repeats 3 times
(3) result:
The staphylococcus aureus fungistatic effect of the product that Comparative Examples makes
The staphylococcus aureus fungistatic effect of the product that embodiment 1 makes
The staphylococcus aureus fungistatic effect of the product that embodiment 2 makes
The staphylococcus aureus fungistatic effect of the product that embodiment 3 makes
The staphylococcus aureus fungistatic effect of the product that embodiment 4 makes
The staphylococcus aureus fungistatic effect of the product that embodiment 5 makes
The staphylococcus aureus fungistatic effect of the product that embodiment 6 makes
(4), conclusion: according to " disposable use hygienic article sanitary standard " (GB15979-2002), Herba Sophorae alopecuroidis vagina cleaning bacteriostasis washing liquid under experimental condition, stock solution effect 2min, bacteriostasis rate＞50% to staphylococcus aureus has bacteriostasis.
Two, Candida albicans bacteriostatic experiment
(1) material:
1, experimental strain: in the 5th generation of Candida albicans (ATCC10231), provided by microorganism fungus kind preservation center, Guangdong Microbes Inst
2. disinfectant: be respectively the antibacterial liquid that embodiment 1～6 and Comparative Examples make
3. culture medium: husky fort fluid medium, husky fort agar culture medium
4, diluent (PBS)
(2) method:
1, test basis: " disinfection technology standard " 2002 editions 2.1.11.3.2 items
2, test is stock solution with disinfectant
3, experimental temperature is 20～22 ℃, and experiment repeats 3 times
(3) result:
The Candida albicans fungistatic effect of the product that Comparative Examples makes
The Candida albicans fungistatic effect of the product that embodiment 1 makes
The Candida albicans fungistatic effect of the product that embodiment 2 makes
The Candida albicans fungistatic effect of the product that embodiment 3 makes
The Candida albicans fungistatic effect of the product that embodiment 4 makes
The Candida albicans fungistatic effect of the product that embodiment 5 makes
The Candida albicans fungistatic effect of the product that embodiment 6 makes
(4), conclusion: according to " disposable use hygienic article sanitary standard " (GB15979-2002), Herba Sophorae alopecuroidis vagina cleaning bacteriostasis washing liquid is under experimental condition, and stock solution effect 2min to the oidiomycetic bacteriostasis rate of white＞50%, has bacteriostasis.
Three, escherichia coli bacteriostatic experiment
(1) material:
1, test strain: in the 6th generation of escherichia coli (8099), grinding institute by military medical courses in general institute stream provides.
2. disinfectant: be respectively the antibacterial liquid that embodiment 1～6 and Comparative Examples make
3. culture medium: nutrient broth, Nutrient agar prepares according to a conventional method
4. diluent (PBS)
(2) method:
1, test basis: " disinfection technology standard " 2002 editions 2.1.11.3.2 items
2, test is stock solution with disinfectant
3, experimental temperature is 19～22 ℃, and experiment repeats 3 times
(3) result:
The escherichia coli fungistatic effect of the product that Comparative Examples makes
The escherichia coli fungistatic effect of the product that embodiment 1 makes
The escherichia coli fungistatic effect of the product that embodiment 2 makes
The escherichia coli fungistatic effect of the product that embodiment 3 makes
The escherichia coli fungistatic effect of the product that embodiment 4 makes
The escherichia coli fungistatic effect of the product that embodiment 5 makes
The escherichia coli fungistatic effect of the product that embodiment 6 makes
(4), conclusion: according to " disposable use hygienic article sanitary standard " (GB15979-2002), Herba Sophorae alopecuroidis vagina cleaning bacteriostasis washing liquid is under experimental condition, and stock solution effect 2min to colibacillary bacteriostasis rate＞50%, has bacteriostasis.
The effect of Herba Sophorae alopecuroidis vagina cleaning bacteriostasis washing liquid provided by the invention has obtained a large amount of clinical verifications, illustrates the clinical treatment situation below.
1. patient: Wang; Sex: woman; Age: 35 years old;
Disease is described: the vaginal orifice pruritus, the back that scratches is red and swollen.
Therapeutic Method: use product that embodiment 1 makes according to 3-5: 1 ratio is cleaned pudendum with warm water dilution back, one day twice, uses 3 days continuously.
Therapeutic effect: use that pruritus alleviates after one day, thoroughly cure after three days.
2. patient: Guo; Sex: woman; Age: 45 years old.
Disease is described: vaginal secretions is faint yellow more, and pruritus vulvae or burning sensation see during inspection that vagina is senile change, last atrophoderma, and the wrinkle wall disappears, and it is sliding, poor that epithelium flattens.
Therapeutic Method: use embodiment 2 to make product according to 3-5: 1 ratio is with warm water dilution afterflush vagina, twice on the one.
Therapeutic effect: use two days later that pruritus alleviates, leucorrhea is normal after seven days.
3. patient: week certain; Sex: woman; 29 years old age.
Disease is described: leucorrhea is many, be curdy, the scorching hot pruritus of pudendum and vagina, dysuria.
Therapeutic Method: use embodiment 3 to make product according to 3-5: 1 ratio is with warm water dilution afterflush vagina, twice on the one.
Therapeutic effect: use curdy disappearance two days later, the scorching hot pruritus sx of pudendum, leucorrhea is normal after 7 days, and it is smooth and easy to urinate.
4, patient: Lee; Sex: woman; Age: 17 years old.
Disease is described: pruritus vulvae, swell and ache, leucorrhea bean dregs sample, lower abdomen weigh down and expand.
Therapeutic Method: use embodiment 4 to make product according to 3-5: 1 ratio is cleaned pudendum, twice on the one with warm water dilution back.
Therapeutic effect: use pruritus transference cure after a day, pain alleviates, and leucorrhea is normal after seven days, and dried transference cure swells and ache.
Claims (9)
1. Herba Sophorae alopecuroidis vagina cleaning bacteriostasis washing liquid, it is characterized in that, the solvent of described Herba Sophorae alopecuroidis vagina cleaning bacteriostasis washing liquid is the mixed liquor of water and ethanol, described Herba Sophorae alopecuroidis vagina cleaning bacteriostasis washing liquid comprises following constituent: 35～55g Cortex Phellodendri, 20～40g Cortex Pseudolaricis, 50～70g Caulis Sargentodoxae, 35～55g Radix Scutellariae, these six kinds of medical materials of 25～45g Radix Et Rhizoma Rhei and 30～50g Radix Stemonae are through water extraction and density is concentrated into the water extract of 1.05-1.1g/ml, 35～55g Herba Sophorae alopecuroidis is the ethanol extraction of 8-14 times of ethanol extraction 14-18 hour gained of Herba Sophorae alopecuroidis weight through weight, 38～58g Radix Angelicae Sinensis and 35～55g Pericarpium Zanthoxyli add the volatile oil that obtained in distilled water extraction 6-10 hour and the filtrate of density simmer down to 1.05-1.1g/ml in volatile oil extractor, 2～4g Mentholum, 2～4g Borneolum Syntheticum, 85～115g glycerol, 55～85g tween 80, described Caulis Sargentodoxae has promoting blood circulation to remove obstruction in the collateral, dissipating blood stasis relieves internal heat, the effect of wind dispelling insecticide.
2. Herba Sophorae alopecuroidis vagina cleaning bacteriostasis washing liquid according to claim 1, it is characterized in that the consumption of the raw material of the described Herba Sophorae alopecuroidis vagina cleaning bacteriostasis of every 5000ml washing liquid is as follows: Cortex Phellodendri 40～50g, Cortex Pseudolaricis 25～35g, Caulis Sargentodoxae 55～65g, Radix Scutellariae 35～50g, Radix Et Rhizoma Rhei 30～40g, the Radix Stemonae 35～45g, Herba Sophorae alopecuroidis 40～50g, Radix Angelicae Sinensis 45～55g, Pericarpium Zanthoxyli 40～50g, Mentholum 2～4g, Borneolum Syntheticum 2～4g, glycerol 90～110g, tween 80 55～70g, ethanol 500～2000ml.
3. the preparation method of Herba Sophorae alopecuroidis vagina cleaning bacteriostasis washing liquid is characterized in that, may further comprise the steps:
Step 1, to extract in Cortex Phellodendri 35～55 weight portions, Cortex Pseudolaricis 20～40 weight portions, Caulis Sargentodoxae 50～70 weight portions, Radix Scutellariae 35～55 weight portions, Radix Et Rhizoma Rhei 25～45 weight portions, the Radix Stemonae 30～50 weight portions mixing adding extraction pot, get extracting solution, concentrating density then is 1.05-1.1g/ml;
Step 2, to put into the reflux, extract, device after Herba Sophorae alopecuroidis 35～55 weight portions adding soak with ethanol, reflux, extract,, filtrate is left and taken in filtration, to stir in the final liquid that obtains of this filtrate adding step 1, precipitate with ethanol filters then, recovered alcohol adds distilled water again and precipitates, filters and leave and take filtrate in the filtrate;
Step 3, Radix Angelicae Sinensis 45～55 weight portions, Pericarpium Zanthoxyli 40～50 weight portions are utilized distilled water extraction in volatile oil extractor, the volatile oil that must mix, with the extracting liq of Radix Angelicae Sinensis and Pericarpium Zanthoxyli filter, simmer down to density is liquid, the precipitate with ethanol of 1.05-1.1g/ml, filter, recovered alcohol gets filtrate, this filtrate is joined in the filtrate that step 2 finally obtains, stir;
Step 4, with Mentholum 2～4 weight portions, Borneolum Syntheticum 2～4 weight portion dissolve with ethanols, wrap up the volatile oil of described mixing with 85～115 weight portion glycerol, 55～85 weight portion tween 80s then and with Borneolum Syntheticum, the Mentholum of dissolve with ethanol, it is joined in the final liquid that obtains of step 3, stir evenly, filter and namely get described Herba Sophorae alopecuroidis vagina cleaning bacteriostasis washing liquid.
4. the preparation method of Herba Sophorae alopecuroidis vagina cleaning bacteriostasis washing liquid according to claim 3, it is characterized in that the consumption of the raw material of using in each step is: Cortex Phellodendri 40～50 weight portions, Cortex Pseudolaricis 25～35 weight portions, Caulis Sargentodoxae 55～65 weight portions, Radix Scutellariae 35～50 weight portions, Radix Et Rhizoma Rhei 30～40 weight portions, the Radix Stemonae 35～45 weight portions, Herba Sophorae alopecuroidis 40～50 weight portions, Radix Angelicae Sinensis 45～55 weight portions, Pericarpium Zanthoxyli 40～50 weight portions, Mentholum 2～4 weight portions, Borneolum Syntheticum 2～4 weight portions, glycerol 90～110 weight portions, tween 80 55～70 weight portions.
5. according to the preparation method of claim 3 or 4 described Herba Sophorae alopecuroidis vagina cleaning bacteriostasis washing liquids, it is characterized in that in the step 1, described extracting solution is merged by extracted twice and gets, and adds the distilled water of 8-14 times of weight when extracting, each 1-2 hour at every turn.
6. according to the preparation method of claim 3 or 4 described Herba Sophorae alopecuroidis vagina cleaning bacteriostasis washing liquids, it is characterized in that, the concrete operations flow process of step 2 is: Herba Sophorae alopecuroidis is added put into the reflux, extract, device after 8-14 times of soak with ethanol 1-3 hour, reflux, extract, 14-18 hour, filtrate is left and taken in filtration, to stir in the final liquid that obtains of this filtrate adding step 1, precipitate with ethanol makes the liquid alcohol degree reach 50～65 degree then, after 12-36 hour, filter, recovered alcohol adds distilled water again and precipitates 12-36 hour, filters and leave and take filtrate in the filtrate.
7. according to the preparation method of claim 3 or 4 described Herba Sophorae alopecuroidis vagina cleaning bacteriostasis washing liquids, it is characterized in that, the concrete operations flow process of step 3 is: with Radix Angelicae Sinensis, Pericarpium Zanthoxyli joins in the volatile oil extractor respectively, each adds 6-10 times of weight distilled water extraction, extracted 6-10 hour, collect and mix two kinds of volatile oil, the extracting liq of above-mentioned Radix Angelicae Sinensis and Pericarpium Zanthoxyli is merged filtration, simmer down to density is the liquid of 1.05-1.1g/ml, precipitate with ethanol also makes the liquid alcohol degree reach 50～65 degree, filter, recovered alcohol, filtrate, this filtrate is joined in the liquid that step 2 finally obtains, stir.
8. according to the preparation method of claim 3 or 4 described Herba Sophorae alopecuroidis vagina cleaning bacteriostasis washing liquids, it is characterized in that in the step 4, the ethanol of dissolving Mentholum, Borneolum Syntheticum is the ethanol of 95 weight % of 10～30 weight portions.
9. according to the preparation method of claim 3 or 4 described Herba Sophorae alopecuroidis vagina cleaning bacteriostasis washing liquids, it is characterized in that described Cortex Phellodendri, Cortex Pseudolaricis, Caulis Sargentodoxae, Radix Scutellariae, Radix Et Rhizoma Rhei, the Radix Stemonae, Herba Sophorae alopecuroidis, Radix Angelicae Sinensis and Pericarpium Zanthoxyli are 8～12 purpose coarse powder.
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| CN101444576A (en) * | 2008-12-31 | 2009-06-03 | 内蒙古永业生物技术有限责任公司 | Method for preparing seed of lightyellow sophora bacteriostasis pudendum-cleaning lotion |
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| CN101444576A (en) * | 2008-12-31 | 2009-06-03 | 内蒙古永业生物技术有限责任公司 | Method for preparing seed of lightyellow sophora bacteriostasis pudendum-cleaning lotion |
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