CN102764208B - Formula and preparation method of anti-dandruff itching-relieving shampoo - Google Patents
Formula and preparation method of anti-dandruff itching-relieving shampoo Download PDFInfo
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- CN102764208B CN102764208B CN201210212267.8A CN201210212267A CN102764208B CN 102764208 B CN102764208 B CN 102764208B CN 201210212267 A CN201210212267 A CN 201210212267A CN 102764208 B CN102764208 B CN 102764208B
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Abstract
The invention discloses a formula and a preparation method of an anti-dandruff itching-relieving shampoo. The formula of the anti-dandruff and itching-relieving shampoo is composed of the following components, by weight: 5-45% of Casuarina equisetifolia, 10-25% of groundsel, 20-25% of mulberry, 20-25% of soapberry and 5-20% of licorice. The shampoo provided by the invention employs a conveniently carried and easily used water aqua, and aims to clear away heat, detoxify, promote blood circulation, remove blood stasis, maintain hair follicle cells, promote metabolism of follicles, eliminate dandruff and relieve itching. A key technical point in the invention is that it is found that a Chinese herbal extract mainly comprising Casuarina equisetifolia has effects of effectively removing dandruff, reliving itching and maintaining scalp health.
Description
Technical field
The present invention relates to antipruritic shampoo prescription of a kind of natural plant anti-dandruff and preparation method thereof.
Background technology
Raising along with living standard, people also improve constantly beautiful pursuit, wish oneself to gather around with the bright healthy hair quality of pitch-black show, especially do not have squarrose puzzlement, the birth of the hair washing solution of the natural removing scurf and relieving itching of the pure plant of expectation dandruff removing, care scalp is more healthy, and sebum secretion is normal, without the puzzlement of dandruff.For a long time, dandruff-removing itching-relieve shampoo is the target that youngster is pursued, almost the preparation containing zinc, the shampoo as removing scurf and relieving itching is used in hair caring circle, containing zinc and compound initial stage thereof, take effect, life-time service wants continuous escalated dose just effective, and thereby the secretion that can not fundamentally improve sebum suppresses the generation of the dandruff, therefore, can safeguard scalp health, control fat secretion, this needs are catered in the generation of the pure natural plant hair washing solution of the chlosma that the inhibition dandruff produces, and have very wide market.
The traditional Chinese medical science thinks, the generation of the dandruff is that heat in blood has wind due to surfeit delicious food savoury, and retention of damp-heat in the interior causes sebum extremely to overflow, thereby occurs maculopapule and desquamation.Endogenous dryness, heat in blood, damp and hot be its main pathogenesis.Therefore, meet the tendency and use when having the Chinese herbal medicine of the anti-chlosma of heat clearing and damp drying during treatment, should help the Chinese herbal medicine with nourishing YIN and benefiting blood, clearing heat and moistening dryness, dispelling wind for relieving itching, removing heat from blood and promoting blood circulation, the physiological environment of conditioning scalp, could suppress dandruff recurrence.
Summary of the invention
The object of this invention is to provide a kind of safe and reliablely, effectively antipruritic shampoo of anti-dandruff and preparation method thereof, can effectively solve dandruff many, scalp pruritus, the unhealthy hair problem causing that waits of scalp.
To achieve these goals, the present invention adopts following technical scheme:
A shampoo prescription, by the component of following percetage by weight, made:
Casuarina equisetifolia L. 5-45%,
Herba Senecionis Scandentis 10-25%,
Cortex Mori 20-25%,
Fructus Sapindi Mukouossi 20-25%,
Radix Glycyrrhizae 5-20%.
The preparation method of above-mentioned dandruff-removing itching-relieve shampoo prescription, comprises the steps: each pulverizing medicinal materials to mix, and crosses 20 mesh sieves, adopt alcoholic solution percolation, percolate reclaims ethanol to thick paste shape, obtains herbal extract, add plant antiseptic agent, it is 5.5 that citric acid is adjusted pH value, obtains shampoo.Described alcoholic solution is 95 %(quality preferably) alcoholic solution.
Compared with prior art, the present invention has following beneficial effect:
The present invention selects easy to carry, easy-to-use water preparation.With heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, maintenance hair follicle cell, promote hair follicle metabolism, eliminate the dandruff, antipruritic be object.
Key technology point of the present invention is to find that Casuarina equisetifolia L. is that main Chinese medicine extraction liquid is effectively eliminated the dandruff, antipruritic, the effect of safeguarding scalp health.
The specific embodiment
Embodiment 1
Get 300 grams, Casuarina equisetifolia L., 150 grams of Herba Senecionis Scandentiss, 250 grams of Cortex Mori, 200 grams of Fructus Sapindi Mukouossis, 100 grams of mixing of Radix Glycyrrhizae, pulverize, cross 20 mesh sieves, with 95% ethanol 5000 ml percolation, percolate reclaims ethanol to thick paste shape, obtains 1000 milliliters of extracting solution, adds plant antiseptic agent.Citric acid is adjusted pH value 5.5, i.e. dandruff-removing itching-relieve shampoo.
Embodiment 2
Get 100 grams, Casuarina equisetifolia L., 100 grams of Herba Senecionis Scandentiss, 200 grams of Cortex Mori, 250 grams of Fructus Sapindi Mukouossis, 200 grams of mixing of Radix Glycyrrhizae, pulverize, cross 20 mesh sieves, with 95% ethanol 5000 ml percolation, percolate reclaims ethanol to thick paste shape, obtains 1000 milliliters of extracting solution, adds plant antiseptic agent.Citric acid is adjusted pH value 5.5, i.e. dandruff-removing itching-relieve shampoo.
Embodiment 3
Get 450 grams, Casuarina equisetifolia L., 250 grams of Herba Senecionis Scandentiss, 200 grams of Cortex Mori, 200 grams of Fructus Sapindi Mukouossis, 50 grams of mixing of Radix Glycyrrhizae, pulverize, cross 20 mesh sieves, with 95% ethanol 5000 ml percolation, percolate reclaims ethanol to thick paste shape, obtains 1000 milliliters of extracting solution, adds plant antiseptic agent.Citric acid is adjusted pH value 5.5, i.e. dandruff-removing itching-relieve shampoo.
clinical experiment:
1. clinical observation:
Inclusion criteria: 20-55 years old ages, men and women did not limit.Select head to have dandruff, head pruritus 155 examples in various degree.Wash hair weekly three times, surrounding is a course for the treatment of
Criterion of therapeutical effect: 1. recovery from illness: naked eyes are without the visible dandruff, and the anesthesia of head pruritus is 2. effective: naked eyes have the fragmentary dandruff, 3. effective without the sensation of head pruritus: it is more than 70% 4. invalid that the dandruff disappears: unchanged before and after using.
Table 1
| The grouping number of cases effective enabledisable total effective rate of fully recovering |
| Embodiment 1 155 135 13 52 95% |
Table 2
| The grouping number of cases effective enabledisable total effective rate of fully recovering |
| Embodiment 2 155 135 13 52 95% |
Table 3
| The grouping number of cases effective enabledisable total effective rate of fully recovering |
| Embodiment 3 155 135 13 52 95% |
2. laboratory observation:
1. the preparation of medicinal liquid
Utilize method described in embodiment 1 to make Chinese medicine extraction liquid, the Chinese medicine extraction liquid of 100000mg/L is directly diluted to experimental concentration with chlosma fluid medium, be respectively 10000,5000,2500,1250,625,312.5,1.56,78,39,19.5mg/L, add Microdilution version (ELISA Plate at the bottom of 96 hole circles), every hole 100 μ L, chlosma fluid medium dilution for ketoconazole liquid, concentration is respectively 32,16,8,4,2,1,0.5,0.25,0.12,0.06mg/L, the final concentration <1% of DMSO.Establish the normal growth contrast that does not add the negative control group of bacterium and do not add medicinal liquid ,-20 ℃ save backup simultaneously, and every kind of medicine is two rows simultaneously, and result is got the meansigma methods of 2 numbers.
2. collecting cells and inoculation
Tested bacterium is cultivated twice in the continuous passage of olive oil culture medium shirt, to guarantee bacterium colony purification and vigor, the 2nd time 32 ℃ go down to posterity and cultivate after 4 days, with physiological saline solution eluting, purify bacterium colony, make bacteria suspension, use than turbid instrument adjust its to Maxwell No. 4 opacity tube concentration.Through blood cell counting plate, count its bacterial content for (1.0 ~ 2.0) * 10
7cFU/mL, with 10 times of fluid medium dilution bacterium liquid, its bacterial content is (1.0 ~ 2.0) * 10
6cFU/mL. get the microwell plate preparing and melt out under room temperature, in microwell plate, every hole (except negative control group) adds bacterium liquid 100 μ L, makes its most total bacteria concentration for (0.5 ~ 1.0) * 10
6cFU/mL.Negative control group adds the fluid medium of equivalent.The final concentration of each Chinese herbal medicine is respectively 5000,2500,1250,625,312.5,156,78,39,19.5,9.8mg/L, and the final concentration of ketoconazole is 16,8,4,2,1,0.5,0.25,0.125,0.06,0.03mg/L.
3 cultivate and result evaluation
The well plates of having inoculated is put to (humidification) in 35 ℃ of calorstats and hatch, observed result after 48h, because chlosma is to have a liking for fat, bacterium colony floats over liquid surface, micro-yellow, and thin layer swims in transparent liquid primary surface, perusal is very clear, adopts direct method reading out data.The prerequisite of result judgement is that growth control is good, and blank asepsis growth is clear, and other hole raises and the growth restriction system of bacterium with drug level gradient.Owing to there being conditions of streaking, by growing state in every hole and growth control comparison, to grow, suppressed 80% be judged to be MIC value.
Table 4 chlosma is to the MIC scope of different pharmaceutical concentration and average (mg/L)
| Medicine | MIC | Average |
| Casuarina equisetifolia L. | 0.25-1.5 | 0.86 |
| Herba Senecionis Scandentis | 0.78-3.9 | 2.3 |
| Cortex Mori | 5.2-11.2 | 6.7 |
| Fructus Sapindi Mukouossi | 5.4-10.9 | 8.2 |
| Radix Glycyrrhizae | 2.5-10.1 | 6.5 |
| Chinese medicine extraction liquid | 0.24-3.6 | 0.76 |
Claims (2)
1. a dandruff-removing itching-relieve shampoo, is characterized in that being made by the component of following percetage by weight:
Casuarina equisetifolia L. 5-45%,
Herba Senecionis Scandentis 10-25%,
Cortex Mori 20-25%,
Fructus Sapindi Mukouossi 20-25%,
Radix Glycyrrhizae 5-20%;
The preparation method of described dandruff-removing itching-relieve shampoo prescription, comprises the steps: each pulverizing medicinal materials to mix, and crosses 20 mesh sieves, adopt alcoholic solution percolation, percolate reclaims ethanol to thick paste shape, obtains herbal extract, add plant antiseptic agent, it is 5.5 that citric acid is adjusted pH value, obtains shampoo.
2. dandruff-removing itching-relieve shampoo as claimed in claim 1, is characterized in that described alcoholic solution is 95%(quality) alcoholic solution.
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| CN103520051B (en) * | 2013-10-18 | 2015-04-08 | 柳州两面针股份有限公司 | Hair and body shampoo |
| CN108261369A (en) * | 2018-02-09 | 2018-07-10 | 广州御延堂生物科技有限公司 | A kind of composite plant shampoo and preparation method thereof |
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| CN1040503C (en) * | 1994-07-02 | 1998-11-04 | 重庆奥妮化妆品有限公司(中外合资) | Shampoo containing nutritive dandruff-removing antipruritic traditional Chinese medicine additive |
| CN101249058B (en) * | 2008-02-26 | 2011-06-29 | 昆明理工大学 | Anti-dandruff relieve itching hair washing cream liquid containing inorganic salt and Chinese medicine, and preparation thereof |
| CN102397202A (en) * | 2011-11-18 | 2012-04-04 | 大连得达科技发展有限公司 | Chinese medicine anti-hair loss and hair-growing shampoo |
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