CN111803422A - Oil control composition and application thereof - Google Patents
Oil control composition and application thereof Download PDFInfo
- Publication number
- CN111803422A CN111803422A CN202010825397.3A CN202010825397A CN111803422A CN 111803422 A CN111803422 A CN 111803422A CN 202010825397 A CN202010825397 A CN 202010825397A CN 111803422 A CN111803422 A CN 111803422A
- Authority
- CN
- China
- Prior art keywords
- oil control
- parts
- skin
- control composition
- oil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 61
- YJCJVMMDTBEITC-UHFFFAOYSA-N 10-hydroxycapric acid Chemical compound OCCCCCCCCCC(O)=O YJCJVMMDTBEITC-UHFFFAOYSA-N 0.000 claims abstract description 50
- 239000000284 extract Substances 0.000 claims abstract description 31
- 244000308505 Filipendula ulmaria Species 0.000 claims abstract description 29
- 235000016622 Filipendula ulmaria Nutrition 0.000 claims abstract description 29
- WQXNXVUDBPYKBA-YFKPBYRVSA-N ectoine Chemical compound CC1=[NH+][C@H](C([O-])=O)CCN1 WQXNXVUDBPYKBA-YFKPBYRVSA-N 0.000 claims abstract description 28
- 239000002994 raw material Substances 0.000 claims abstract description 10
- 239000006071 cream Substances 0.000 claims abstract description 5
- 230000001815 facial effect Effects 0.000 claims description 6
- 239000006210 lotion Substances 0.000 claims description 5
- -1 serums Substances 0.000 claims description 3
- 229940100616 topical oil Drugs 0.000 claims 5
- 210000002966 serum Anatomy 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 28
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 18
- 239000002537 cosmetic Substances 0.000 abstract description 11
- 230000028327 secretion Effects 0.000 abstract description 11
- 230000008591 skin barrier function Effects 0.000 abstract description 11
- 239000000686 essence Substances 0.000 abstract description 6
- 230000007774 longterm Effects 0.000 abstract description 6
- 230000008439 repair process Effects 0.000 abstract description 6
- 239000000839 emulsion Substances 0.000 abstract description 5
- 230000006872 improvement Effects 0.000 abstract description 5
- 239000004519 grease Substances 0.000 abstract description 3
- 239000003921 oil Substances 0.000 description 73
- 210000003491 skin Anatomy 0.000 description 23
- 239000000047 product Substances 0.000 description 22
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 21
- 230000008859 change Effects 0.000 description 15
- 238000003756 stirring Methods 0.000 description 15
- 210000004369 blood Anatomy 0.000 description 14
- 239000008280 blood Substances 0.000 description 14
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 14
- 150000002632 lipids Chemical class 0.000 description 10
- 230000007935 neutral effect Effects 0.000 description 10
- 238000002156 mixing Methods 0.000 description 9
- 238000002360 preparation method Methods 0.000 description 9
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 8
- 239000000419 plant extract Substances 0.000 description 8
- 229960003237 betaine Drugs 0.000 description 7
- 229960005150 glycerol Drugs 0.000 description 7
- 235000011187 glycerol Nutrition 0.000 description 7
- 238000010438 heat treatment Methods 0.000 description 6
- 210000004027 cell Anatomy 0.000 description 5
- 230000000052 comparative effect Effects 0.000 description 5
- 238000001816 cooling Methods 0.000 description 5
- 230000002401 inhibitory effect Effects 0.000 description 5
- 239000000523 sample Substances 0.000 description 5
- 210000001732 sebaceous gland Anatomy 0.000 description 5
- CHADEQDQBURGHL-UHFFFAOYSA-N (6'-acetyloxy-3-oxospiro[2-benzofuran-1,9'-xanthene]-3'-yl) acetate Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(OC(C)=O)C=C1OC1=CC(OC(=O)C)=CC=C21 CHADEQDQBURGHL-UHFFFAOYSA-N 0.000 description 4
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 4
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 description 4
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 4
- WQXNXVUDBPYKBA-UHFFFAOYSA-N Ectoine Natural products CC1=NCCC(C(O)=O)N1 WQXNXVUDBPYKBA-UHFFFAOYSA-N 0.000 description 4
- 206010015150 Erythema Diseases 0.000 description 4
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 4
- 206010039792 Seborrhoea Diseases 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 229960000458 allantoin Drugs 0.000 description 4
- 230000006870 function Effects 0.000 description 4
- 239000011159 matrix material Substances 0.000 description 4
- 230000037312 oily skin Effects 0.000 description 4
- 229960005323 phenoxyethanol Drugs 0.000 description 4
- 239000011148 porous material Substances 0.000 description 4
- 239000000600 sorbitol Substances 0.000 description 4
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 3
- 238000004945 emulsification Methods 0.000 description 3
- 210000000887 face Anatomy 0.000 description 3
- 239000003925 fat Substances 0.000 description 3
- 235000019197 fats Nutrition 0.000 description 3
- 210000001061 forehead Anatomy 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- VOFUROIFQGPCGE-UHFFFAOYSA-N nile red Chemical compound C1=CC=C2C3=NC4=CC=C(N(CC)CC)C=C4OC3=CC(=O)C2=C1 VOFUROIFQGPCGE-UHFFFAOYSA-N 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 239000002453 shampoo Substances 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- FYGDTMLNYKFZSV-URKRLVJHSA-N (2s,3r,4s,5s,6r)-2-[(2r,4r,5r,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5r,6s)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1[C@@H](CO)O[C@@H](OC2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-URKRLVJHSA-N 0.000 description 2
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
- 229940100555 2-methyl-4-isothiazolin-3-one Drugs 0.000 description 2
- AJBZENLMTKDAEK-UHFFFAOYSA-N 3a,5a,5b,8,8,11a-hexamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-4,9-diol Chemical compound CC12CCC(O)C(C)(C)C1CCC(C1(C)CC3O)(C)C2CCC1C1C3(C)CCC1C(=C)C AJBZENLMTKDAEK-UHFFFAOYSA-N 0.000 description 2
- 229940100484 5-chloro-2-methyl-4-isothiazolin-3-one Drugs 0.000 description 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- 208000002874 Acne Vulgaris Diseases 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- 229920002498 Beta-glucan Polymers 0.000 description 2
- 235000003880 Calendula Nutrition 0.000 description 2
- 240000001432 Calendula officinalis Species 0.000 description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 2
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 description 2
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 2
- FPVVYTCTZKCSOJ-UHFFFAOYSA-N Ethylene glycol distearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCOC(=O)CCCCCCCCCCCCCCCCC FPVVYTCTZKCSOJ-UHFFFAOYSA-N 0.000 description 2
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
- 235000018936 Vitellaria paradoxa Nutrition 0.000 description 2
- 241001135917 Vitellaria paradoxa Species 0.000 description 2
- 206010000496 acne Diseases 0.000 description 2
- BTBJBAZGXNKLQC-UHFFFAOYSA-N ammonium lauryl sulfate Chemical compound [NH4+].CCCCCCCCCCCCOS([O-])(=O)=O BTBJBAZGXNKLQC-UHFFFAOYSA-N 0.000 description 2
- 229940063953 ammonium lauryl sulfate Drugs 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- DHNRXBZYEKSXIM-UHFFFAOYSA-N chloromethylisothiazolinone Chemical compound CN1SC(Cl)=CC1=O DHNRXBZYEKSXIM-UHFFFAOYSA-N 0.000 description 2
- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 description 2
- 229940073507 cocamidopropyl betaine Drugs 0.000 description 2
- 230000003750 conditioning effect Effects 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 230000005284 excitation Effects 0.000 description 2
- 238000004108 freeze drying Methods 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 229940075529 glyceryl stearate Drugs 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 230000003834 intracellular effect Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 229910001629 magnesium chloride Inorganic materials 0.000 description 2
- BEGLCMHJXHIJLR-UHFFFAOYSA-N methylisothiazolinone Chemical compound CN1SC=CC1=O BEGLCMHJXHIJLR-UHFFFAOYSA-N 0.000 description 2
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 2
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 2
- 230000003204 osmotic effect Effects 0.000 description 2
- 229940086539 peg-7 glyceryl cocoate Drugs 0.000 description 2
- 229960000502 poloxamer Drugs 0.000 description 2
- 229920001983 poloxamer Polymers 0.000 description 2
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 2
- 239000008213 purified water Substances 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 229940057910 shea butter Drugs 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 229940057950 sodium laureth sulfate Drugs 0.000 description 2
- SXHLENDCVBIJFO-UHFFFAOYSA-M sodium;2-[2-(2-dodecoxyethoxy)ethoxy]ethyl sulfate Chemical compound [Na+].CCCCCCCCCCCCOCCOCCOCCOS([O-])(=O)=O SXHLENDCVBIJFO-UHFFFAOYSA-M 0.000 description 2
- UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 2
- 230000002195 synergetic effect Effects 0.000 description 2
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- 229940043810 zinc pyrithione Drugs 0.000 description 2
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 2
- 229960001763 zinc sulfate Drugs 0.000 description 2
- 229910000368 zinc sulfate Inorganic materials 0.000 description 2
- PICXIOQBANWBIZ-UHFFFAOYSA-N zinc;1-oxidopyridine-2-thione Chemical compound [Zn+2].[O-]N1C=CC=CC1=S.[O-]N1C=CC=CC1=S PICXIOQBANWBIZ-UHFFFAOYSA-N 0.000 description 2
- OYINQIKIQCNQOX-UHFFFAOYSA-M 2-hydroxybutyl(trimethyl)azanium;chloride Chemical compound [Cl-].CCC(O)C[N+](C)(C)C OYINQIKIQCNQOX-UHFFFAOYSA-M 0.000 description 1
- UIVPNOBLHXUKDX-UHFFFAOYSA-N 3,5,5-trimethylhexyl 3,5,5-trimethylhexanoate Chemical compound CC(C)(C)CC(C)CCOC(=O)CC(C)CC(C)(C)C UIVPNOBLHXUKDX-UHFFFAOYSA-N 0.000 description 1
- VFKZECOCJCGZQK-UHFFFAOYSA-M 3-hydroxypropyl(trimethyl)azanium;chloride Chemical compound [Cl-].C[N+](C)(C)CCCO VFKZECOCJCGZQK-UHFFFAOYSA-M 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 241001116389 Aloe Species 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- 244000303965 Cyamopsis psoralioides Species 0.000 description 1
- 230000005778 DNA damage Effects 0.000 description 1
- 231100000277 DNA damage Toxicity 0.000 description 1
- 102000009024 Epidermal Growth Factor Human genes 0.000 description 1
- 101800003838 Epidermal growth factor Proteins 0.000 description 1
- 206010064571 Gene mutation Diseases 0.000 description 1
- 229920002907 Guar gum Polymers 0.000 description 1
- 241000206595 Halomonas elongata Species 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 108020005196 Mitochondrial DNA Proteins 0.000 description 1
- QZXSMBBFBXPQHI-UHFFFAOYSA-N N-(dodecanoyl)ethanolamine Chemical compound CCCCCCCCCCCC(=O)NCCO QZXSMBBFBXPQHI-UHFFFAOYSA-N 0.000 description 1
- 108091093105 Nuclear DNA Proteins 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- 108010020346 Polyglutamic Acid Proteins 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 206010039793 Seborrhoeic dermatitis Diseases 0.000 description 1
- 240000006688 Telosma cordata Species 0.000 description 1
- 235000017352 Telosma cordata Nutrition 0.000 description 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 229940069521 aloe extract Drugs 0.000 description 1
- 235000011399 aloe vera Nutrition 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 150000003862 amino acid derivatives Chemical class 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O ammonium group Chemical class [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000003385 bacteriostatic effect Effects 0.000 description 1
- 239000007640 basal medium Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 230000005779 cell damage Effects 0.000 description 1
- 208000037887 cell injury Diseases 0.000 description 1
- 210000002390 cell membrane structure Anatomy 0.000 description 1
- 229940081733 cetearyl alcohol Drugs 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 229940080421 coco glucoside Drugs 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- PKPOVTYZGGYDIJ-UHFFFAOYSA-N dioctyl carbonate Chemical compound CCCCCCCCOC(=O)OCCCCCCCC PKPOVTYZGGYDIJ-UHFFFAOYSA-N 0.000 description 1
- 238000002845 discoloration Methods 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 229940116977 epidermal growth factor Drugs 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- SFNALCNOMXIBKG-UHFFFAOYSA-N ethylene glycol monododecyl ether Chemical compound CCCCCCCCCCCCOCCO SFNALCNOMXIBKG-UHFFFAOYSA-N 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 239000012091 fetal bovine serum Substances 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 229920000370 gamma-poly(glutamate) polymer Polymers 0.000 description 1
- 229930182478 glucoside Natural products 0.000 description 1
- 150000008131 glucosides Chemical class 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 239000000665 guar gum Substances 0.000 description 1
- 235000010417 guar gum Nutrition 0.000 description 1
- 229960002154 guar gum Drugs 0.000 description 1
- 210000004209 hair Anatomy 0.000 description 1
- 210000003780 hair follicle Anatomy 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 229940100554 isononyl isononanoate Drugs 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
- 229960002216 methylparaben Drugs 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 1
- 125000002801 octanoyl group Chemical group C(CCCCCCC)(=O)* 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- UWJJYHHHVWZFEP-UHFFFAOYSA-N pentane-1,1-diol Chemical compound CCCCC(O)O UWJJYHHHVWZFEP-UHFFFAOYSA-N 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 230000008832 photodamage Effects 0.000 description 1
- 230000036619 pore blockages Effects 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 229960003415 propylparaben Drugs 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 239000001044 red dye Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 229940109850 royal jelly Drugs 0.000 description 1
- 208000008742 seborrheic dermatitis Diseases 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 230000037075 skin appearance Effects 0.000 description 1
- 230000004215 skin function Effects 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 230000007279 water homeostasis Effects 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/008—Preparations for oily skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/008—Preparations for oily hair
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/10—General cosmetic use
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
Abstract
The invention provides an oil control composition which comprises the following raw materials in parts by weight: 0.01-5 parts of ectoin, 1-10 parts of spiraea ulmaria extract and 0.01-10 parts of 10-hydroxydecanoic acid. The oil control composition can be applied to external oil control products, and the addition amount of the oil control composition in the external oil control products is 1-20%. The external oil control product can be cosmetic water, essence, cream or emulsion. The oil control composition of the present invention reduces the problem of system instability due to the spiraea ulmaria extract. The skin care product has excellent function of controlling grease secretion, can quickly eliminate oily and greasy feeling, brings fresh feeling to skin, can gradually balance the water and oil composition of the skin after long-term use, helps repair skin barriers, and can show continuous oil control effect after being stopped. In addition, the combination of the three components also has a better improvement effect on the condition of face reddening.
Description
Technical Field
The invention belongs to the field of cosmetics, and relates to an oil control composition and application thereof.
Background
Due to bad living habits such as work and rest, irregular diet and the like, internal reasons such as endocrine disturbance, psychological stress and the like, objective factors such as environmental pollution and the like, people who mix skin or oily skin rise year by year, and the oily skin is difficult to be quickly improved once formed and affects the appearance of the individual, so that the problem that more and more people are troubled is solved. Oily skin is formed as a result of the exuberant secretion of skin oil, which causes a shiny, oily look and poor skin appearance, such as acne and seborrheic dermatitis. In addition, people with oily skin often have unbalanced skin barrier function, pores are enlarged by accumulated grease, and the skin gradually loses elasticity.
At present, the existing oil-control cosmetics in the market usually mainly comprise oil-absorbing powder such as silicon dioxide, titanium dioxide, talc or plant extracts, wherein the powder particles are used for quickly filling pores and absorbing redundant oil so as to improve the problem of skin oily gloss, the oily gloss of the skin can be temporarily reduced, the symptoms and root causes can not be treated, even the excessive addition of the plant extracts can cause the problems of pore blockage and the like, and the plant extracts such as calendula, aloe, Chinese violet and the like have small side effects but have the problems of slow effect taking, easiness in repetition and the like.
CN 101874768A discloses an oil-controlling cosmetic composition, which comprises the following components in percentage by weight: 0.01-10% of water-soluble zinc salt, 0.1-8% of oil absorption powder, 0.1-15% of royal jelly extract and 0.1-10% of natural Chinese herbal medicine extract. The composition can reduce oil secretion and absorb skin oil. However, the product has no effect of repairing skin barrier, cannot continuously maintain water-oil balance of skin after being stopped, and does not solve the problem that facial red blood streak is more.
CN 106661676A discloses a plant extract for controlling oil and shrinking pores, a preparation method and an application thereof, the raw material components comprise: 15-25 parts of rice fermentation liquor, 35-35 parts of calendula extract, 15-25 parts of aloe extract and 25-35 parts of Daphne lanuginosa fruit oil. The composition has a good effect of inhibiting the secretion of oil, but there is no mention of the effects of repairing the skin barrier and continuously controlling oil, nor the problem of reducing the redness of the face.
Disclosure of Invention
Aiming at the problems that the existing oil control cosmetics cannot continuously maintain the water-oil balance of skin and do not have the function of repairing skin barriers, the invention provides the oil control composition which can continuously control oil, repair the skin barriers and reduce the problem of face redness.
It is another object of the present invention to provide a use of the above oil control composition in cosmetics.
In order to achieve the purpose, the invention adopts the following technical scheme.
An oil control composition comprises the following raw materials in parts by weight: 0.01-5 parts of ectoin, 1-10 parts of spiraea ulmaria extract and 0.01-10 parts of 10-hydroxydecanoic acid.
Preferably, the oil control composition comprises the following raw materials in parts by weight: 1 part of ectoin, 1 part of spiraea ulmaria extract and 3 parts of 10-hydroxydecanoic acid. When the preferable proportion is adopted, the obtained product has better performance in all aspects.
The Ectoine, spiraea ulmaria extract and 10-hydroxydecanoic acid can be commercially obtained from the above oil control composition.
The oil control composition is simple and convenient to prepare, and is obtained by directly mixing a certain amount of ectoin, spiraea ulmaria extract and 10-hydroxydecanoic acid in distilled water, fully stirring to uniformly disperse and dissolve the components, and freeze-drying.
An application of the oil control composition in an external oil control product.
The oil control composition can be added with conventional adjuvants in the field, and processed into various common cosmetic dosage forms by conventional method, such as cosmetic water, essence, lotion, cream, shampoo, hair care product, etc., for controlling excessive secretion of facial or head skin oil.
An external oil control product comprising the oil control composition.
The addition amount of the oil control composition in the external oil control product is 1-20%, preferably 3-15%, and more preferably 10%. The addition amount of the oil control composition can be selected according to the dosage form of the external oil control product.
The mechanism/synergy of the present invention is as follows:
ectoin is derived from highly halophilic bacteria (Halomonas Elongata) Is a natural small molecular amino acid derivative. Under the extreme conditions of high salt, high temperature and high ultraviolet radiation, the ectoin can protect halophilic bacteria from being damaged by severe environment. Ectoine can be said to be a compatible solute produced intracellularly by salt tolerant organisms to maintain osmotic balance to regulate intracellular and extracellular osmotic balance. Therefore, ectoin has the effects of osmoregulation, stabilization of protein hydration layer, inhibition of UV-induced cell damage (mitochondrial gene mutation, nuclear DNA damage, etc.), and protection of cell membrane structure. Are often used in cosmetic applications to prevent photodamage to the skin, to resist haze, and the like. The 10-hydroxydecanoic acid (10-HDAA) can reduce the number of active sebaceous glands, effectively inhibit oil secretion, has excellent bacteriostatic activity and inhibits various pathogenic microorganisms, thereby reducing inflammatory reaction caused by the exuberant oil secretion. Both the ectoin and the 10-HDAA have the functions of exterior and interior, and the problems of oily and shiny appearance and the like of the face are solved from inside to outside.
The spiraea ulmaria extract is a natural product extracted from the flower bud of the spiraea ulmaria, and is effective in astringing large pores, inhibiting abnormal oil production of hair follicles and conditioning sebaceous glands of a human body. Inhibiting bacterial reproduction and preventing acne, thereby achieving the effect of conditioning skin. However, as a plant extract, the plant extract is influenced by temperature and changes the properties, so that after the plant extract is added into a formula, the color of a product is deepened when the product is subjected to high temperature, and the application range and the addition amount of the plant extract are greatly influenced. The composition can avoid the problem of discoloration of the spiraea ulmaria extract in the formula, and the three components are mutually cooperated, so that the high-temperature stability of the spiraea ulmaria extract and the product is greatly improved.
The invention has the following advantages:
the composition consists of ectoin, the spiraea ulmaria extract and 10-hydroxydecanoic acid (10-HDAA), and the problem of system instability caused by the spiraea ulmaria extract is reduced when the composition with a specific proportion is used in a formula. The skin care product has excellent function of controlling grease secretion, can quickly eliminate oily light and greasy feeling, brings fresh feeling to skin, can gradually balance skin water and oil composition after long-term use, helps repair skin barriers, and can show continuous oil control effect after being stopped. In addition, the combination of the three components also has a better improvement effect on the condition of face reddening.
Drawings
FIG. 1 is a color comparison of application example 1 and application example 13 after storage at a constant temperature of 55 ℃ for 10 days.
Detailed Description
The present invention will be further described with reference to the following examples and drawings, but the present invention is not limited to the following examples.
Example 1 preparation of oil control composition
Weighing ectoin, spiraea ulmaria extract and 10-hydroxydecanoic acid according to compositions of samples 1-6 and comparative samples 1-5 in the following table 1 (g), adding distilled water until the components are completely dispersed and dissolved, fully stirring and uniformly mixing, and freeze-drying to obtain an oil-controlling composition; the control samples 6-8 were taken directly.
TABLE 1 formulation of various oil control compositions
EXAMPLE 2 inhibition of sebaceous gland secretion by different products
The oil control effect of the experimental examples and the comparative examples was examined by examining the synthesis of neutral lipids in human sebaceous gland cells during the cell culture:
SZ95 human sebaceous gland cells cultured in vitro are selected and cultured in a Sebomed basal medium, and 10% fetal bovine serum, 5 mug/L epidermal growth factor, 100U/ml penicillin and 100 mug/ml streptomycin are added. Standing at 37 deg.C for 5% CO2In the incubator, the culture medium was changed every 2 days for one time. Cells were seeded in 96-well plates, samples 1-6 and controls 1-8 of the same mass were added the next day, the supernatant was discarded after 48h incubation, washed twice with PBS, and repeatedly pipetted into two portions, one portion was added with Nile Red dye (1 mg/ml, dissolved in acetone, -stored at 20 ℃) diluted in PBS to a final concentration of 10. mu.g/ml, and one portion was added with Fluorescein Diacetate (FDA) (5 mg/ml dissolved in DMSO, -stored at 20 ℃) diluted in PBS to a final concentration of 15. mu.g/ml. Detecting the fluorescence intensity of different samples, wherein Nile Red uses 485nm as an excitation wavelength, detects an emission wavelength at 565nm, FDA uses 494nm as an excitation wavelength, detects an emission wavelength at 523nm, and the fluorescence intensity is calculated according to the following formula: percent (%) intracellular neutral lipids (= nile red fluorescence intensity/FDA fluorescence intensity × 100%. The experimental data are as follows:
TABLE 2
The different letters in the table represent significant differences at the 5% level (p < 0.05).
From the data in the above table, it can be seen that the composition has the least neutral lipid content of 10-hydroxydecanoic acid and the most neutral lipid content of ectoin, indicating that 10-hydroxydecanoic acid is the most excellent and ectoin is the least effective for oil control. For the combination of two of the three components, the combination of the spiraea ulmaria extract and the 10-hydroxydecanoic acid is obviously superior to the single use of the spiraea ulmaria extract, and the content of neutral lipid of the combination of the spiraea ulmaria extract and the ectoine and the single use of the spiraea ulmaria extract are not obviously different. The composition mixed according to the proportion of 1-10 parts by weight of the spiraea ulmaria extract, 0.01-5 parts by weight of the ectoine and 0.01-10 parts by weight of the 10-hydroxydecanoic acid has lower neutral lipid content, and the neutral lipid content after the three components are combined is obviously better than that after the three components are combined in pairs for use, which shows that the three components in the composition have the function of synergistically inhibiting the secretion of cell neutral lipid. Compared with the sample 1 with the optimal proportion, the content of neutral lipid of the comparative samples 3-5 is obviously increased when the proportion of the spiraea ulmaria extract is too low and the 10-hydroxydecanoic acid or the ectoin is excessive, which shows that the effect of inhibiting the secretion of the neutral lipid of the cells can be best only when the spiraea ulmaria extract, the 10-hydroxydecanoic acid and the ectoin are in proper proportion.
EXAMPLE 3 preparation of oil-controlling emulsions
The oil control emulsions were prepared according to the following table using conventional methods, with samples 1-6 being prepared as application examples 1-6 and comparative samples 1-8 being prepared as application examples 8-15.
TABLE 3
The preparation method of the oil control emulsion comprises the steps of adding purified water into an emulsification tank, sequentially adding xanthan gum, betaine, glycerol, methylparaben and propylparaben into the emulsification tank, stirring and heating to 75-80 ℃, sequentially adding cetearyl glucoside, cetearyl alcohol, dioctyl carbonate, isononyl isononanoate and VE acetate into an oil phase tank, heating to 75-80 ℃, pumping into the emulsification tank, homogenizing for a plurality of minutes, cooling to 40-45 ℃, sequentially adding the oil control composition and phenoxyethanol prepared in the example 1, stirring until all materials are completely dissolved, and cooling to normal temperature to obtain the oil control emulsion.
Comparative example 1
According to CN 101874768A, an oil-controlling cosmetic composition is disclosed, which comprises the following specific components:
TABLE 4
The controlled-release ointment is prepared according to the common method and is numbered as application example 7.
Example 4 oil control Effect of different products
100 healthy subjects were recruited by self-control method, randomly divided into 5 groups, the left half face was treated with a matrix containing no oil control composition, the right half face was treated with application examples 1, 7, 9, 13, 14, respectively, and then the fat content of the forehead of the left and right half faces was measured (using an instrument of multi-probe skin test system MPA 580 (Courage + Khazaka, germany; oil and fat dispensing test kit), and the oil control efficacy of the product was evaluated.
The specific implementation mode is as follows: the subjects used the same amount of the base and different samples for 30 minutes after cleaning the face with the mild face cleanser, then used the same amount of the base and different samples for the left and right faces, respectively, once in the morning and at night, and detected the indexes 1h, 6h, 3d, 7d, 14d, and 28d after the first day of use in the morning (first time), and then stopped using, and detected again at 14d (test 42 d), and the oil change rate of the right face to the left face was calculated, and the oil change rate (%) = (right face oil content-left face oil content)/left face oil content x 100%, with lower values indicating more oil reduction.
TABLE 5 oil control effect of different products (% change in fat)
Different letters in the table represent that different samples at the same time differ significantly at the 5% level (p < 0.05).
As can be seen from the above table, compared with the prior art in application example 7, application example 1 has significantly improved instantaneous oil control effect at 1h and 6h and long-term oil control effect at 28d, and is also significantly superior to application example 13 in which the spiraea ulmaria extract is used alone and application example 14 in which the 10-hydroxydecanoic acid is used alone in the same period, which indicates that the compositions of the present invention have synergistic oil control effect with each other. As can be seen by comparing the change rates of the fats and oils of the subjects after the use of 28d and the non-use of 14d (test 42 d), example 1 containing ectoin is significantly superior to application example 9 containing no ectoin, which shows that application example 1 of the present invention can exert the effect of long-term lasting oil control.
EXAMPLE 5 Effect of different products in repairing skin Barrier and improving Red blood streak
50 healthy subjects were enrolled using the self-control method, using the vehicle without the oil control composition for the left half face and application examples 1, 8, 13, 14, and 15 for the right half face, respectively. Detecting the skin moisture loss content of the forehead of the left half and the forehead of the right half of the face by using a skin moisture loss tester Tewameter TM300 (Courage + Khazaka, Germany), and evaluating the repairing effect of the product on the skin barrier; the effect of removing red blood streak was evaluated by measuring the ratio of red blood streak in the skin of the apple muscles of the left and right half faces using a facial image analyzer VISIA-CR (Canfield, USA).
The specific implementation mode is as follows: the test subject cleans the face with mild face cleanser for 30 minutes, then uses the same amount of matrix and different samples for the left half face and the right half face respectively, uses the matrix and the different samples once in the morning and at the evening, continuously uses the matrix and the different samples for 28 days, and detects the water loss 1h, 6h, 3d, 7d, 14d and 28d after the first morning (first use); the water content and the ratio of red blood filaments to the skin were measured at 3d, 7d, 14d, 28d after use and 14d after the stop of use (test 42 d), respectively. Then, the rate of change in the moisture content of the right face to the left face and the rate of change in the red blood cell are calculated, respectively, and the rate of change in the moisture content (%) = (the moisture content of the right face-the moisture content of the left face)/the moisture content of the left face × 100%. Lower values indicate greater barrier repair efficacy. The red blood streak change rate (%) = (right-left-face red blood streak ratio)/left-face red blood streak ratio × 100%, and a lower value indicates a stronger red blood streak improving ability.
TABLE 6 skin Barrier repair Effect (moisture content Rate of change) for different products
In the table, different letters represent that different samples at the same time differ significantly at the 5% level (p < 0.05)
As can be seen from the above table, the instantaneous skin moisture change after 6 hours of application, the short-term skin moisture change after 7 days of application and the long-term skin moisture change after 28 days of application example 1 are all significantly better than the application examples 13 to 15 in which the three components are used alone and the application example 8 in which ectoin is used in combination with the spiraea ulmaria extract, which shows that the three components used in combination have a synergistic effect on the instantaneous moisturizing and long-term skin barrier repair effects. Application example 1 is still significantly superior to application examples 8, 13-15 in terms of skin moisture change after 14 days of rest (test 42 d), which demonstrates that prolonged use of the oil control composition of the present invention improves skin function, enhances its barrier effect, and prevents water loss.
TABLE 7 different products improve the effect of red blood streak
As can be seen from the above table, application example 1 has a very significant improvement effect on facial red blood streak, and the effect is still significant after the application example is stopped, the red blood streak is reduced by 13.52% compared with the original red blood streak, and application examples 8, 13, 14 and 15 have no improvement or no significant improvement on facial red blood streak.
Example 6 product stability
And (3) subpackaging the application examples 1, 5, 6, 9 and 13 into transparent glass sample bottles, respectively placing the transparent glass sample bottles into a constant temperature experiment box at 55 ℃, respectively observing the color change after 1d, 3d and 10d, and cooling the sample to room temperature before observation.
TABLE 8 high temperature stability of the different products
As is clear from the above data and fig. 1, application examples 9 and 13 turned light yellowish brown on day 3 of storage, as compared with milky white color of application examples 1, 5 and 6 after storage at high temperature. This indicates that the spiraea ulmaria extract can change color at high temperature without adding ectoin and 10-hydroxydecanoic acid, and further affect the color and stability of the product.
Example 7 preparation of oil control composition and cosmetic
1. Toning lotion
The raw materials comprise: oil control composition (1 part by weight of ectoin, 1 part by weight of spiraea ulmaria extract and 2 parts by weight of 10-hydroxydecanoic acid) 1%, glycerol 2%, betaine 1%, allantoin 0.2%, phenoxyethanol 0.6%, and water to 100%;
the preparation method comprises the following steps: mixing glycerol, betaine and allantoin, and stirring to obtain mixture A; and adding the oil control composition and phenoxyethanol into the mixture A, and uniformly mixing and stirring to obtain the toning lotion.
2. Essence liquid
The raw materials comprise: oil control composition (1 part by weight of ectoin, 1 part by weight of spiraea ulmaria extract and 4 parts by weight of 10-hydroxydecanoic acid) 3%, poloxamer 40.8%, glycerol 8%, sorbitol 5%, betaine 2%, allantoin 0.2%, acetyl chitosamine 0.5% and beta-glucan 1%; 2% of pentanediol and 1% of caprylyl hydroximic acid; 0.1 percent of triethanolamine and water to 100 percent;
the preparation method comprises the following steps: taking a proper amount of glycerol and sorbitol to moisten poloxamer and an oil control composition; adding purified water into the mixture, and feeding the mixture into a high-pressure homogenizer for homogenizing for 2 times, wherein the rotating speed is 12000rpm/min, and each time lasts for 3 minutes; then adding the rest components, adjusting the pH value to about 6.5, and stirring until the components are uniformly mixed to obtain the essence.
3. Oil control cream
The raw materials comprise: 15% of oil control composition (1.5 parts by weight of ectoin, 1 part by weight of spiraea ulmaria extract and 3 parts by weight of 10-hydroxydecanoic acid), 5% of glyceryl stearate, 10% of caprylic/capric triglyceride, 5% of shea butter, 3% of glycerol, 2% of sorbitol, 2% of betaine, 0.05% of allantoin, 0.5% of acetyl chitosamine, 0.8% of beta-glucan, 0.2% of sodium polyglutamate, 0.6% of phenoxyethanol and water to 100%;
the preparation method comprises the following steps: weighing glyceryl stearate, caprylic/capric triglyceride and shea butter according to a proportion, mixing, and heating to 70-75 deg.C to obtain mixture A; taking a proper amount of glycerol and sorbitol, fully dispersing and dissolving the oil-controlling composition, continuously adding a proper amount of water, adding other components while stirring, uniformly mixing, and heating to 70-75 ℃ to obtain a mixture B; a, B, mixing, homogenizing for 5-8 minutes, stirring to 45-40 ℃, adding antiseptic and acid-base regulator, and mixing to obtain oil control cream.
4. Shampoo liquid
The raw materials comprise: oil control composition (0.5 parts by weight of ectoin, 1 part by weight of spiraea ulmaria extract, 3 parts by weight of 10-hydroxydecanoic acid) 20%, ammonium lauryl sulfate 3%, sodium laureth sulfate 12%, laureth-251%, polyquaternium-100.2%, polyquaternium-220.5%, guar hydroxypropyltrimonium chloride 0.5%, potassium laureth phosphate 5%, cocamidopropyl betaine 5%, coconut monoethanolamide 4%, PEG-7 glyceryl cocoate 3%, ethylene glycol distearate 1%, 1% of betaine, 0.05% of styrene acrylate copolymer, 0.05% of coco glucoside, 0.1% of disodium EDTA, 0.03% of methyl chloro isothiazolinone, 0.01% of methyl isothiazolinone, 0.01% of magnesium chloride, 1.5% of sodium chloride, 1% of zinc pyrithione, 0.5% of zinc sulfate, 0.3% of essence and water to 100%;
the preparation method comprises the following steps: slowly adding polyquaternium-10 and guar gum hydroxypropyl trimethyl ammonium chloride into appropriate amount of water, dispersing and stirring to be uniform to obtain phase A; adding ammonium lauryl sulfate, sodium laureth sulfate, laureth-25, polyquaternary ammonium salt-22 and disodium EDTA into appropriate amount of water, mixing, heating to 50-55 deg.C, stirring for dissolving, adding phase A, stirring, heating to 75-80 deg.C, maintaining the temperature, and stirring for 1 h; cooling to 55-60 deg.C, adding cocamidopropyl betaine, cocamidoethanol amide, and zinc pyrithione, and stirring; and continuously cooling to 40-45 ℃, adding the oil control composition, betaine, PEG-7 glyceryl cocoate, ethylene glycol distearate, methyl chloro isothiazolinone, methyl isothiazolinone, essence, magnesium chloride, sodium chloride and zinc sulfate, and stirring uniformly to obtain the shampoo.
Claims (7)
1. The oil control composition is characterized by comprising the following raw materials in parts by weight: 0.01-5 parts of ectoin, 1-10 parts of spiraea ulmaria extract and 0.01-10 parts of 10-hydroxydecanoic acid.
2. The oil control composition according to claim 1, comprising the following raw materials in parts by weight: 1 part of ectoin, 1 part of spiraea ulmaria extract and 3 parts of 10-hydroxydecanoic acid.
3. Use of an oil control composition according to claim 1 or 2 in an external oil control product.
4. Use according to claim 3, wherein the topical oil control product is in a form selected from the group consisting of lotions, serums, creams and lotions.
5. Use according to claim 3, wherein the topical oil control product is applied to the facial skin or the head skin.
6. A topical oil control product comprising the oil control composition of claim 1 or 2.
7. The topical oil control product according to claim 6, wherein the oil control composition is added in an amount of 1-20%, preferably 3-15%, and more preferably 10% to the topical oil control product.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202010825397.3A CN111803422B (en) | 2020-08-17 | 2020-08-17 | Oil control composition and application thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202010825397.3A CN111803422B (en) | 2020-08-17 | 2020-08-17 | Oil control composition and application thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
CN111803422A true CN111803422A (en) | 2020-10-23 |
CN111803422B CN111803422B (en) | 2023-06-20 |
Family
ID=72859406
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202010825397.3A Active CN111803422B (en) | 2020-08-17 | 2020-08-17 | Oil control composition and application thereof |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN111803422B (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112545911A (en) * | 2020-12-24 | 2021-03-26 | 华熙生物科技股份有限公司 | Compositions, care agents, uses and methods for reducing skin irritation |
CN112870136A (en) * | 2021-01-12 | 2021-06-01 | 吴维碧 | Shampoo for patients with seborrheic dermatitis and preparation method thereof |
CN114306152A (en) * | 2021-11-26 | 2022-04-12 | 广州市科能化妆品科研有限公司 | Oil control composition for hair and application thereof |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2004123614A (en) * | 2002-10-03 | 2004-04-22 | Arysta Lifescience Corp | Skin care preparation for external use |
US20090047226A1 (en) * | 2006-04-28 | 2009-02-19 | Teckenbrock Gertraud | Quick-drying cosmetic emulsions for roll-on application |
CN107789308A (en) * | 2017-11-06 | 2018-03-13 | 诺斯贝尔化妆品股份有限公司 | A kind of gentle oil control and acne removal elite |
CN107951823A (en) * | 2017-12-06 | 2018-04-24 | 懿奈(上海)生物科技有限公司 | It is a kind of that there is the composition of oil-control and its application |
CN109091433A (en) * | 2018-10-22 | 2018-12-28 | 广州智尚生物科技有限公司 | A kind of composition of oil control and acne removal and its application in cosmetics |
CN109562082A (en) * | 2016-05-31 | 2019-04-02 | 莱雅公司 | Anti-acne compsn and application method |
CN111281832A (en) * | 2020-04-02 | 2020-06-16 | 广州一一生物技术有限公司 | Skin barrier repair compound, toning lotion and preparation method thereof |
-
2020
- 2020-08-17 CN CN202010825397.3A patent/CN111803422B/en active Active
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2004123614A (en) * | 2002-10-03 | 2004-04-22 | Arysta Lifescience Corp | Skin care preparation for external use |
US20090047226A1 (en) * | 2006-04-28 | 2009-02-19 | Teckenbrock Gertraud | Quick-drying cosmetic emulsions for roll-on application |
CN109562082A (en) * | 2016-05-31 | 2019-04-02 | 莱雅公司 | Anti-acne compsn and application method |
CN107789308A (en) * | 2017-11-06 | 2018-03-13 | 诺斯贝尔化妆品股份有限公司 | A kind of gentle oil control and acne removal elite |
CN107951823A (en) * | 2017-12-06 | 2018-04-24 | 懿奈(上海)生物科技有限公司 | It is a kind of that there is the composition of oil-control and its application |
CN109091433A (en) * | 2018-10-22 | 2018-12-28 | 广州智尚生物科技有限公司 | A kind of composition of oil control and acne removal and its application in cosmetics |
CN111281832A (en) * | 2020-04-02 | 2020-06-16 | 广州一一生物技术有限公司 | Skin barrier repair compound, toning lotion and preparation method thereof |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112545911A (en) * | 2020-12-24 | 2021-03-26 | 华熙生物科技股份有限公司 | Compositions, care agents, uses and methods for reducing skin irritation |
CN112545911B (en) * | 2020-12-24 | 2023-06-20 | 华熙生物科技股份有限公司 | Compositions, care agents, uses and methods for reducing skin irritation |
CN112870136A (en) * | 2021-01-12 | 2021-06-01 | 吴维碧 | Shampoo for patients with seborrheic dermatitis and preparation method thereof |
CN114306152A (en) * | 2021-11-26 | 2022-04-12 | 广州市科能化妆品科研有限公司 | Oil control composition for hair and application thereof |
Also Published As
Publication number | Publication date |
---|---|
CN111803422B (en) | 2023-06-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN111803422B (en) | Oil control composition and application thereof | |
CN110742842B (en) | Essence composition for delaying skin aging and preparation method thereof | |
CN111971022B (en) | Use of a composition for preventing or reducing the appearance of signs of inflammation | |
CN115400065B (en) | Skin care product composition with multiple effects of moisturizing, anti-wrinkle, anti-aging, relieving and repairing and application thereof | |
KR101702648B1 (en) | A preservative for skin external application, and a cosmetic composition and a pharmaceutical composition comprising the same | |
CN108852976B (en) | Crystal moistening nourishing lotion | |
JP2008013565A (en) | Cosmetic method for limiting formation of hollowing of face | |
CN116850114B (en) | Composition for relieving and repairing and cream for relieving and repairing | |
CN116509774B (en) | Anti-dandruff shampoo preparation containing sweet wormwood herb extract and preparation method thereof | |
JP2000053533A (en) | Ceramide synthesis-promoting agent and cosmetic, quasi- drug and preparation for external use for skin containing the same ceramide synthesis-promoting agent | |
CN112294739A (en) | Multi-effect whitening composition and application thereof in moisturizer | |
KR20170001067A (en) | A preservative for skin external application, and a cosmetic composition and a pharmaceutical composition comprising the same | |
KR102161942B1 (en) | Anti-acne cosmetic composition and method for manufacturing the same | |
EP3364938B1 (en) | Mixtures comprising climbazole | |
CN114983917A (en) | Soothing deep moisturizing emulsion and preparation method thereof | |
JP2023102152A (en) | Low-irritant cosmetic | |
TWI687237B (en) | Use of extract of victoria cruziana for inducing expression of keratin gene and hyaluronan synthase 2 gene, and enhancing moisture-retaining capacity of skin | |
JPH0429919A (en) | Moisture-retaining cosmetic | |
KR20160020038A (en) | Cosmetic Composition containing Frangipani Oil or Fermented Frangipani Oil | |
CN115487098B (en) | Skin care emulsion and preparation method thereof | |
JP7366048B2 (en) | Novel compositions based on polycaffeoylquinic acids, their cosmetic uses and cosmetic compositions containing them | |
CN114796013A (en) | Oil control composition and application thereof in cosmetics | |
KR20010094747A (en) | Cosmetics | |
WO2024099715A1 (en) | A skin brightening composition | |
CN116617132A (en) | Anti-aging composition and application thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20230525 Address after: 250000 Tianchen Street 678, Jinan Hi-tech Development Zone, Shandong Province Applicant after: BLOOMAGE BIOTECH Co.,Ltd. Address before: No. 3333, middle section of Century Avenue, hi tech Zone, Lixia District, Jinan City, Shandong Province Applicant before: SHANDONG BLOOMAGE HYINC BIOPHARM Corp.,Ltd. |
|
TA01 | Transfer of patent application right | ||
GR01 | Patent grant | ||
GR01 | Patent grant |