CN115487098B - Skin care emulsion and preparation method thereof - Google Patents
Skin care emulsion and preparation method thereof Download PDFInfo
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- CN115487098B CN115487098B CN202211298340.8A CN202211298340A CN115487098B CN 115487098 B CN115487098 B CN 115487098B CN 202211298340 A CN202211298340 A CN 202211298340A CN 115487098 B CN115487098 B CN 115487098B
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- 239000000839 emulsion Substances 0.000 title claims abstract description 53
- 238000002360 preparation method Methods 0.000 title abstract description 17
- 238000004945 emulsification Methods 0.000 title description 2
- 230000003712 anti-aging effect Effects 0.000 claims abstract description 18
- 239000004205 dimethyl polysiloxane Substances 0.000 claims abstract description 17
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims abstract description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 17
- -1 polydimethylsiloxane Polymers 0.000 claims abstract description 15
- BXCRLBBIZJSWNS-UHFFFAOYSA-N 2-hydroxyethyl hexadecanoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCCO BXCRLBBIZJSWNS-UHFFFAOYSA-N 0.000 claims abstract description 11
- 229940049964 oleate Drugs 0.000 claims abstract description 11
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims abstract description 11
- 239000008367 deionised water Substances 0.000 claims abstract description 8
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 8
- 239000003755 preservative agent Substances 0.000 claims abstract description 8
- 230000002335 preservative effect Effects 0.000 claims abstract description 8
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 7
- 229940087073 glycol palmitate Drugs 0.000 claims abstract description 5
- 150000005846 sugar alcohols Polymers 0.000 claims abstract description 5
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 23
- XOJVHLIYNSOZOO-SWOBOCGESA-N Arctiin Chemical compound C1=C(OC)C(OC)=CC=C1C[C@@H]1[C@@H](CC=2C=C(OC)C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O)=CC=2)C(=O)OC1 XOJVHLIYNSOZOO-SWOBOCGESA-N 0.000 claims description 21
- BPYGTFFYYOWDBC-LOVSFRALSA-N arctiin Natural products COc1ccc(C[C@H]2COC(=O)[C@@H]2Cc3ccc(O[C@@H]4O[C@H](C)[C@@H](O)[C@H](O)[C@H]4O)c(OC)c3)cc1OC BPYGTFFYYOWDBC-LOVSFRALSA-N 0.000 claims description 20
- JXPHIHWXMBYJAU-UHFFFAOYSA-N 7-methoxy-2,2-dimethyl-3,4-dihydrochromen-6-ol Chemical compound O1C(C)(C)CCC2=C1C=C(OC)C(O)=C2 JXPHIHWXMBYJAU-UHFFFAOYSA-N 0.000 claims description 17
- 229940117973 dimethylmethoxy chromanol Drugs 0.000 claims description 17
- KDULJHFMZBRAHO-UHFFFAOYSA-N cioteronel Chemical compound C1C(=O)CC2C(CCCCC(CC)OC)CCC21 KDULJHFMZBRAHO-UHFFFAOYSA-N 0.000 claims description 16
- 239000003921 oil Substances 0.000 claims description 15
- 235000019198 oils Nutrition 0.000 claims description 15
- 238000000034 method Methods 0.000 claims description 13
- 239000000203 mixture Substances 0.000 claims description 9
- 244000144725 Amygdalus communis Species 0.000 claims description 8
- 235000011437 Amygdalus communis Nutrition 0.000 claims description 8
- 239000008168 almond oil Substances 0.000 claims description 8
- 235000015112 vegetable and seed oil Nutrition 0.000 claims description 8
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 7
- 238000010438 heat treatment Methods 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 6
- 238000003756 stirring Methods 0.000 claims description 6
- DNIAPMSPPWPWGF-VKHMYHEASA-N (+)-propylene glycol Chemical compound C[C@H](O)CO DNIAPMSPPWPWGF-VKHMYHEASA-N 0.000 claims description 5
- YPFDHNVEDLHUCE-UHFFFAOYSA-N 1,3-propanediol Substances OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 claims description 5
- 229940035437 1,3-propanediol Drugs 0.000 claims description 5
- 235000018330 Macadamia integrifolia Nutrition 0.000 claims description 5
- 240000000912 Macadamia tetraphylla Species 0.000 claims description 5
- 235000003800 Macadamia tetraphylla Nutrition 0.000 claims description 5
- 239000010466 nut oil Substances 0.000 claims description 5
- 229920000166 polytrimethylene carbonate Polymers 0.000 claims description 5
- 229940015975 1,2-hexanediol Drugs 0.000 claims description 4
- 238000004090 dissolution Methods 0.000 claims description 4
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 claims description 4
- 229920005862 polyol Polymers 0.000 claims description 4
- 150000003077 polyols Chemical class 0.000 claims description 4
- SHBUUTHKGIVMJT-UHFFFAOYSA-N Hydroxystearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OO SHBUUTHKGIVMJT-UHFFFAOYSA-N 0.000 claims description 3
- 235000021302 avocado oil Nutrition 0.000 claims description 3
- 239000008163 avocado oil Substances 0.000 claims description 3
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims description 3
- 238000001816 cooling Methods 0.000 claims description 3
- 239000000539 dimer Substances 0.000 claims description 3
- 229940072106 hydroxystearate Drugs 0.000 claims description 3
- 235000008390 olive oil Nutrition 0.000 claims description 3
- 239000004006 olive oil Substances 0.000 claims description 3
- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical compound CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 claims description 3
- 239000010497 wheat germ oil Substances 0.000 claims description 3
- CUNWUEBNSZSNRX-RKGWDQTMSA-N (2r,3r,4r,5s)-hexane-1,2,3,4,5,6-hexol;(z)-octadec-9-enoic acid Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O CUNWUEBNSZSNRX-RKGWDQTMSA-N 0.000 claims description 2
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical group OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims description 2
- ANZUDYZHSVGBRF-UHFFFAOYSA-N 3-ethylnonane-1,2,3-triol Chemical compound CCCCCCC(O)(CC)C(O)CO ANZUDYZHSVGBRF-UHFFFAOYSA-N 0.000 claims description 2
- 229960005323 phenoxyethanol Drugs 0.000 claims description 2
- 229960005078 sorbitan sesquioleate Drugs 0.000 claims description 2
- 239000003974 emollient agent Substances 0.000 claims 1
- 239000002304 perfume Substances 0.000 claims 1
- 230000007794 irritation Effects 0.000 abstract description 6
- 230000000694 effects Effects 0.000 abstract description 5
- 102000008186 Collagen Human genes 0.000 abstract description 4
- 108010035532 Collagen Proteins 0.000 abstract description 4
- 230000015572 biosynthetic process Effects 0.000 abstract description 4
- 229920001436 collagen Polymers 0.000 abstract description 4
- 102000016942 Elastin Human genes 0.000 abstract description 3
- 108010014258 Elastin Proteins 0.000 abstract description 3
- 108010003272 Hyaluronate lyase Proteins 0.000 abstract description 3
- 102000001974 Hyaluronidases Human genes 0.000 abstract description 3
- 229920002549 elastin Polymers 0.000 abstract description 3
- 229960002773 hyaluronidase Drugs 0.000 abstract description 3
- 238000003786 synthesis reaction Methods 0.000 abstract description 3
- 230000001939 inductive effect Effects 0.000 abstract description 2
- 230000002401 inhibitory effect Effects 0.000 abstract description 2
- 230000002000 scavenging effect Effects 0.000 abstract description 2
- 210000003491 skin Anatomy 0.000 description 63
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- 230000037303 wrinkles Effects 0.000 description 8
- 238000009472 formulation Methods 0.000 description 7
- 235000011187 glycerol Nutrition 0.000 description 7
- 230000003020 moisturizing effect Effects 0.000 description 4
- 230000008859 change Effects 0.000 description 3
- 239000002537 cosmetic Substances 0.000 description 3
- 230000032798 delamination Effects 0.000 description 3
- 239000006210 lotion Substances 0.000 description 3
- 230000037394 skin elasticity Effects 0.000 description 3
- 230000002195 synergetic effect Effects 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 2
- 230000006978 adaptation Effects 0.000 description 2
- 230000032683 aging Effects 0.000 description 2
- 201000010251 cutis laxa Diseases 0.000 description 2
- 230000008021 deposition Effects 0.000 description 2
- 239000007933 dermal patch Substances 0.000 description 2
- 230000001815 facial effect Effects 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 239000003906 humectant Substances 0.000 description 2
- 230000000670 limiting effect Effects 0.000 description 2
- 239000002932 luster Substances 0.000 description 2
- 230000002438 mitochondrial effect Effects 0.000 description 2
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- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 230000008439 repair process Effects 0.000 description 2
- 230000036548 skin texture Effects 0.000 description 2
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 206010002198 Anaphylactic reaction Diseases 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 1
- 229920002683 Glycosaminoglycan Polymers 0.000 description 1
- 208000028990 Skin injury Diseases 0.000 description 1
- 206010040914 Skin reaction Diseases 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 238000004378 air conditioning Methods 0.000 description 1
- 208000003455 anaphylaxis Diseases 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
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- 238000000691 measurement method Methods 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
Abstract
The invention discloses a skin care emulsion and a preparation method thereof. The skin care emulsion comprises the following components in percentage by weight: 4-8% of polyalcohol, 6-12% of skin-moistening oil, 1-2% of anti-aging factor, 3-5% of emulsifier, 3-5% of glycol palmitate, 2-4% of PPG-26 oleate, 0.5-2% of polydimethylsiloxane, 0.5-1% of preservative and the balance of deionized water. The skin care emulsion provided by the invention has remarkable anti-aging effects by scavenging free radicals, repairing elastin, inducing collagen synthesis, inhibiting hyaluronidase activity and the like, and has stable system property and low irritation.
Description
Technical Field
The invention belongs to the technical field of cosmetics, and particularly relates to skin care emulsion and a preparation method thereof.
Background
Skin aging is a natural law, and is influenced by objective factors such as age, heredity and the like, as well as various factors such as sunlight, environment, health and the like. Especially, modern people have high living pressure, stay up for night, stay for a long time in computers, smoking, sleep deficiency, long-time stay in air conditioning rooms, drinking, excessive eyes and the like, become living normalcy, greatly accelerate skin aging, cause facial skin to be loose, rough, wrinkle to increase, skin complexion to be dark, color spots to be deposited and lack of luster.
Research shows that skin oxidation is the biggest threat to skin aging, and free radicals are the core factors causing skin aging, and are accompanied by the whole process of primary, middle and later skin aging. The invasion of free radicals damages the structure of proteins, accelerates the passage of young proteins, and causes early aging of skin; the free radicals can destroy cellular DNA, so that collagen and elastic fibers lose elasticity, the skin resistance is reduced, wrinkles are deepened, looseness is aggravated, and skin aging in the middle stage is caused; free radicals can hinder the formation of mitochondrial ATP, and insufficient mitochondrial energy can cause rough and dull skin, loose wrinkles, and cause later aging of the skin.
At present, the skin care cosmetics with anti-aging effect on the market have different components, but the content of active ingredients is very low, the angles considered in the process of carrying out formula design aiming at the problems of loose skin, rough skin, increased wrinkles, dark complexion, color spot deposition and lack of gloss caused by skin aging are not comprehensive, the reasons for forming the problems cannot be considered in all directions, and finally, the use effect of the skin care products is not obvious.
Disclosure of Invention
The invention aims to provide skin care emulsion and a preparation method thereof. The skin care emulsion has remarkable anti-aging effects by scavenging free radicals, repairing elastin, inducing collagen synthesis, inhibiting hyaluronidase activity and the like, and has stable system property and low irritation.
The invention is realized by the following technical scheme:
a skin care emulsion comprising the following components in weight percent: 4-8% of polyalcohol, 6-12% of skin-moistening oil, 1-2% of anti-aging factor, 3-5% of emulsifier, 3-5% of glycol palmitate, 2-4% of PPG-26 oleate, 0.5-2% of polydimethylsiloxane, 0.5-1% of preservative and the balance of deionized water.
Preferably, the anti-aging factor is composed of (0.1-0.5) and (0.01-0.05) by (1-2) by weight of ethoxyheptyl bicyclooctanone, dimethylmethoxy chromanol and arctiin.
Preferably, the anti-aging factor is composed of ethoxyheptyl bicyclooctanone, dimethylmethoxy chromanol and arctiin according to the weight ratio of 0.45:0.05:1.5.
Preferably, the polyol is any one or more of 1, 3-propanediol, glycerol, butanediol, 1, 2-pentanediol and 1, 2-hexanediol.
Preferably, the skin-moistening oil is any one or more of white pool flower seed oil, avocado oil, macadamia nut oil, sweet almond oil, olive oil and wheat germ oil.
Preferably, the emulsifier is any one or more of PEG-30 dimer hydroxystearate, cetyl PEG/PPG-10/1 polydimethylsiloxane and sorbitan sesquioleate.
Preferably, the preservative is phenoxyethanol, ethylhexyl glycerol or a mixture of the two. Preferably, the preservative is Shumei GermanyPE 9010。
Preferably, the skin care emulsion further comprises 0-0.05% of essence.
Preferably, the skin care emulsion further comprises EDTA-2Na 0-0.05%.
The invention also provides a preparation method of the skin care emulsion, which comprises the following steps:
s1, mixing skin-moistening oil, an emulsifier, glycol palmitate, PPG-26 oleate and polydimethylsiloxane, heating to 80-90 ℃, and stirring for dissolution to obtain an oil phase;
s2, mixing the polyalcohol, the preservative and the water, heating to 80-90 ℃, and stirring for dissolution to obtain a water phase;
s3, adding the water phase into the oil phase, homogenizing for 3-5 min at 8000-10000 r/min, cooling to 50-60 ℃, adding the anti-aging factor, homogenizing for 3-5 min at 8000-10000 r/min, and obtaining the skin care emulsion.
According to the invention, ethoxyheptyl bicyclooctanone is an elastin repairing agent, and can obviously improve skin elasticity, repair fine wrinkles and reduce fine wrinkles; the dimethylmethoxy chromanol is a high-efficiency antioxidant, can effectively prevent and repair skin injury caused by ROS, RNS, RCS and the like, and can improve the activity of skin cells; arctiin is the main active ingredient of arctii fructus extract, and can promote synthesis of skin collagen and glycosaminoglycan, and inhibit hyaluronidase activity. The anti-aging factors compounded by the three components exert remarkable anti-aging effect in a synergistic way, and effectively relieve the problems of loose skin, roughness, increased wrinkles, dark complexion, deposition of color spots and lack of luster caused by skin aging.
Meanwhile, by adding a proper amount of polyalcohol as a humectant, the skin care emulsion plays a synergistic moisturizing effect with skin care oil, so that the prepared anti-aging skin care emulsion has a good basic moisturizing effect. In addition, the skin-moistening oil also has the function of promoting penetration, and can obviously reduce the irritation of a system, so that the prepared anti-aging skin-care emulsion is easy to absorb, safe and free from irritation.
The invention has the following beneficial effects:
the three components of the ethoxyheptyl bicyclooctanone, the dimethylmethoxy chromanol and the arctiin in the formula of the skin care emulsion play a synergistic anti-aging role, and a proper amount of polyol humectant and skin-moistening oil are also added into the skin care emulsion, so that the skin care emulsion has good moisturizing effect and can effectively reduce the irritation to skin. The skin care emulsion is mild, has no stimulation, is stable in system and can be used for a long time.
Detailed Description
The following examples are further illustrative of the invention and are not intended to be limiting thereof. The components of the formulations in the examples below, unless otherwise specified, are all conventional commercial products.
Example 1
A skin care emulsion comprising the following components in weight percent: 3% of glycerol, 2% of 1, 3-propanediol, 4% of white pool flower seed oil, 3% of macadamia nut oil, 3% of sweet almond oil, 0.45% of ethoxyheptyl bicyclooctanone, 0.05% of dimethylmethoxychromanol, 1.5% of arctiin, 5% of cetyl PEG/PPG-10/1 polydimethylsiloxane, 5% of ethylene glycol palmitate, 3% of PPG-26 oleate, 1% of polydimethylsiloxane,PE 9010.5%, essence 0.01%, and deionized water in balance.
The preparation method comprises the following steps:
s1, mixing white pool flower seed oil, macadamia nut oil, sweet almond oil, cetyl PEG/PPG-10/1 polydimethylsiloxane, ethylene glycol palmitate, PPG-26 oleate and polydimethylsiloxane, heating to 80 ℃, stirring and dissolving to obtain an oil phase;
s2, glycerin, 1, 3-propanediol,Mixing PE 9010 and water, heating to 80deg.C, stirring for dissolving to obtain water phase;
s3, adding the water phase into the oil phase, homogenizing for 3min at 10000r/min, cooling to 50 ℃, adding ethoxyheptyl bicyclooctanone, dimethyl methoxy chromanol, arctiin and essence, and homogenizing for 3min at 10000r/min to obtain the skin care emulsion.
Example 2
A skin care emulsion comprising the following components in weight percent: glycerol 2%, butanediol 2%, white pond flower seed oil 4%, avocado oil 4%, sweet almond oil 4%, ethoxyheptyl bicyclooctanone 0.5%, dimethylmethoxychromanol 0.01%, arctiin 1.49%, cetyl PEG/PPG-10/1 polydimethylsiloxane 4%, ethylene glycol palmitate 4%, PPG-26 oleate 2%, polydimethylsiloxane 1.5%, and,PE 9010.5%, essence 0.02%, and deionized water in balance.
The preparation procedure is described in example 1.
Example 3
A skin care emulsion comprising the following components in weight percent: glycerol 4%, 1, 3-propanediol 2%, 1, 2-hexanediol 1%, white pond flower seed oil 4%, wheat germ oil 3%, sweet almond oil 2%, ethoxyheptyl bicyclooctanone 0.1%, dimethylmethoxychromanol 0.05%, arctiin 1.85%, cetyl PEG/PPG-10/1 polydimethylsiloxane 4%, ethylene glycol palmitate 3%, PPG-26 oleate 3%, polydimethylsiloxane 1.5%, and,PE 9010.5%, essence 0.03%, and deionized water in balance.
The preparation procedure is described in example 1.
Example 4
A skin care emulsion comprising the following components in weight percent: glycerol 4%2% of 1,2 pentanediol, 4% of white pool flower seed oil, 2% of macadamia nut oil, 2% of sweet almond oil, 0.5% of ethoxyheptyl bicyclooctanone, 0.01% of dimethylmethoxybenzodihydropyranol, 1% of arctiin, 3% of cetyl PEG/PPG-10/1 polydimethylsiloxane, 4% of ethylene glycol palmitate, 4% of PPG-26 oleate, 2% of polydimethylsiloxane,PE 9010%, essence 0.04%, and deionized water in balance.
The preparation procedure is described in example 1.
Example 5
A skin care emulsion comprising the following components in weight percent: 5% of glycerol, 3% of 1, 2-hexanediol, 3% of white pool flower seed oil, 2% of olive oil, 1% of sweet almond oil, 0.1% of ethoxyheptyl bicyclooctanone, 0.01% of dimethylmethoxychromanol, 1% of arctiin, 5% of PEG-30 dimer hydroxystearate, 5% of ethylene glycol palmitate, 4% of PPG-26 oleate, 0.5% of polydimethylsiloxane,PE 9010%, essence 0.05%, and deionized water in balance.
The preparation procedure is described in example 1.
Comparative example 1
The skin care lotion of comparative example 1 was compared with example 1, except that the formulation contained no ethoxyheptyl bicyclooctanone and the amount of arctiin was increased accordingly, the amount of arctiin was 1.95%.
The preparation procedure is described in example 1.
Comparative example 2
The skin care emulsion of comparative example 2 was compared with example 1, except that the formulation contained no dimethylmethoxy chromanol and the amount of arctiin was increased accordingly, which was 1.55%.
The preparation procedure is described in example 1.
Comparative example 3
The skin care emulsion of comparative example 3 was compared to example 1, except that arctiin was not included in the formulation and the amount of dimethylmethoxychromanol was increased accordingly, which was 1.55%.
The preparation procedure is described in example 1.
Comparative example 4
The skin care emulsion of comparative example 4 was compared with example 1, except that the formulation contained no ethoxyheptyl bicyclooctanone and arctiin, and the amount of dimethylmethoxychromanol was correspondingly increased, and the amount of dimethylmethoxychromanol was 2%.
The preparation procedure is described in example 1.
Comparative example 5
The skin care lotion of comparative example 5 was compared with example 1, except that the formulation contained no dimethylmethoxy chromanol and no arctiin, and the amount of ethoxyheptyl bicyclooctanone was correspondingly increased, which was 2%.
The preparation procedure is described in example 1.
Comparative example 6
The skin care emulsion of comparative example 6 was compared with example 1, except that the formulation contained no ethoxyheptyl bicyclooctanone and dimethylmethoxy chromanol, and the amount of arctiin was increased accordingly, the amount of arctiin was 2%.
The preparation procedure is described in example 1.
Test example I, human skin patch test
The skin care emulsions prepared in examples 1 to 5 and comparative examples 1 to 6 of the present invention were tested with reference to the requirements and measurement methods related to the "human skin patch test" in the 2015 edition "cosmetic health Specification" issued by the Ministry of health, and skin reactions were observed at 0h, 6h, 12h, 24h, 48h, respectively, and the experimental results of all volunteer subjects were negative results, and skin adverse reactions did not occur. The skin care emulsion provided by the invention can not cause anaphylactic reaction, has no irritation and high safety.
Test example two, stability test
1. Cold and hot test: the skin care emulsions prepared in examples 1-5 and comparative examples 1-6 were packaged in transparent emulsion bottles, and refrigerated in a refrigerator at 4deg.C for one week without delamination; placing in an incubator at 55 ℃ for 24 hours, and preventing layering.
2. Centrifugal test: the skin care emulsions prepared in examples 1-5 and comparative examples 1-6 were packaged in a tube with a stopper and centrifuged at 3000r/min for 20min, and no delamination occurred.
3. Room temperature standing test: the skin care emulsions prepared in examples 1-5 and comparative examples 1-6 were packaged in transparent emulsion bottles, and were left standing at room temperature (25.+ -. 1 ℃) for 6 months without delamination.
The results show that the skin care emulsion system provided by the invention is stable.
Test example III, evaluation of Using Property
66 volunteer healthy female subjects were selected, aged 28-50 years, all of which had no history of skin allergy, and were divided into 1-11 groups of 6 persons each. The skin care emulsions prepared in examples 1 to 5 were used in groups 1 to 5, respectively, and the skin care emulsions prepared in comparative examples 1 to 6 were used in groups 6 to 11, respectively. After each group of subjects cleaned facial skin daily, the corresponding skin care lotions were applied separately. Before and after 28 days of use, the skin moisture content change was measured by using a skin moisture tester Corneometer CM825, the skin brightness change was measured by using a skin colorimetry tester ColorMeter MAX, and the skin elasticity value and skin texture change were measured by using a skin elasticity tester Cutometer dual MPA and a skin image analysis system SkinVisiometerSV 600. The results are shown in tables 1-2.
TABLE 1
TABLE 2
As can be seen from tables 1-2 above, the skin moisture content, brightness, elasticity, texture depth of the subjects after using the skin care emulsions prepared in examples 1-5 of the present invention were significantly higher than those of the subjects using the skin care emulsions prepared in comparative examples 1-6. The skin care emulsion prepared by the invention can increase the moisture content of skin, improve the brightness of the skin, improve the elasticity of the skin, and reduce the depth of skin texture so as to reduce wrinkles, and has obvious moisturizing and anti-aging effects.
The foregoing is merely a preferred embodiment of the present invention, and it should be noted that the above-mentioned preferred embodiment should not be construed as limiting the invention, and the scope of the invention should be defined by the appended claims. It will be apparent to those skilled in the art that various modifications and adaptations can be made without departing from the spirit and scope of the invention, and such modifications and adaptations are intended to be comprehended within the scope of the invention.
Claims (9)
1. A skin care emulsion, characterized by comprising the following components in percentage by weight: 4-8% of polyalcohol, 6-12% of skin-moistening oil, 1-2% of anti-aging factor, 3-5% of emulsifier, 3-5% of glycol palmitate, 2-4% of PPG-26 oleate, 0.5-2% of polydimethylsiloxane, 0.5-1% of preservative and the balance of deionized water;
the anti-aging factor is composed of (0.1-0.5): 0.01-0.05): 1-2 by weight of ethoxyheptyl bicyclooctanone, dimethylmethoxy chromanol and arctiin.
2. The skin care emulsion of claim 1, wherein the anti-aging factor is composed of ethoxyheptyl bicyclooctanone, dimethylmethoxy chromanol and arctiin according to a weight ratio of 0.45:0.05:1.5.
3. The skin care emulsion of claim 1 wherein the polyol is any one or more of 1, 3-propanediol, glycerol, butanediol, 1, 2-pentanediol, 1, 2-hexanediol.
4. The skin care emulsion of claim 1, wherein the emollient oil is any one or more of white pool seed oil, avocado oil, macadamia nut oil, sweet almond oil, olive oil, wheat germ oil.
5. The skin care emulsion of claim 1, wherein the emulsifier is any one or more of PEG-30 dimer hydroxystearate, cetyl PEG/PPG-10/1 polydimethylsiloxane, sorbitan sesquioleate.
6. The skin care emulsion of claim 1, wherein the preservative is phenoxyethanol, ethylhexyl glycerol, or a mixture of both.
7. The skin care emulsion of claim 1, further comprising 0-0.05% of perfume.
8. The skin care emulsion of claim 1, further comprising EDTA-2na 0-0.05%.
9. A method of preparing the skin care emulsion of any one of claims 1-6, comprising the steps of:
s1, mixing skin-moistening oil, an emulsifier, glycol palmitate, PPG-26 oleate and polydimethylsiloxane, heating to 80-90 ℃, and stirring for dissolution to obtain an oil phase;
s2, mixing polyol, preservative and water, heating to 80-90 ℃, and stirring for dissolution to obtain a water phase;
s3, adding the water phase into the oil phase, homogenizing for 3-5 min at 8000-10000 r/min, cooling to 50-60 ℃, adding the anti-aging factor, and homogenizing for 3-5 min at 8000-10000 r/min to obtain the skin care emulsion.
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