CN106265348A - A kind of substrate with maintenance skin barrier and senile-resistant efficacy and its preparation method and application - Google Patents
A kind of substrate with maintenance skin barrier and senile-resistant efficacy and its preparation method and application Download PDFInfo
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- CN106265348A CN106265348A CN201610835181.9A CN201610835181A CN106265348A CN 106265348 A CN106265348 A CN 106265348A CN 201610835181 A CN201610835181 A CN 201610835181A CN 106265348 A CN106265348 A CN 106265348A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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Abstract
The invention belongs to cosmetic technical field, specifically disclose a kind of substrate with maintenance skin barrier and senile-resistant efficacy, it is made up of following component the most by mass percentage: 3%～4% 1, 2 pentanediols, 10%～15% methyl propanediol, 1%～2% hyaluronate sodium, 3%～5% close Luo Mu leaf/stem extract, 10%～15% elastin hydrolysis, 10%～20% antidotal agent containing 100 ~ 200ppm palmitoyl oligopeptide, 5%～10% tea extract, 0.2%～0.5% cell growth factor stock solution, 3%～5% antidotal agent containing 45 55ppm neurotransmitter suppression class victory peptides, 5%～10% algae extract * and excess water.The skin matrix of the present invention, maintenance skin barrier and defying age are notable, can see effect in a short time, adhere to using, and meeting maintenance skin barrier makes wrinkle reduce.
Description
Technical field
The invention belongs to cosmetic technical field, more particularly, to one, there is maintenance skin barrier and defying age merit
Substrate of effect and its preparation method and application.
Background technology
The horny layer of skin surface is important protective layer, the most referred to as skin barrier.The barrier function of skin is
With the health of skin whether one of important physiological function of skin, have important pass with the selection improved looks and using effect
System.It refers mainly to the skin penetrating function to physics, chemistry, biology and moisture etc..This penetrating function is mainly manifested in epidermis, special
It is not at horny layer, so being commonly referred to as again horny layer or epidermal barrier function.Barrier function is the most weak, and moisture of skin is easily lost,
Cause xerosis cutis；Function of shielding is too strong, and skin can not preferably absorb nutrient substance, causes using effect the best.So, just
When function of shielding be most suitable.Once the barrier function of skin is destroyed, the toleration of skin or defense will under
Fall, shows for various physically or chemically factors and does not tolerates, and such as somebody feels wind, Exposure to Sunlight, the supercool mistake of ambient temperature
Hot skin all can rubescent, twinge；The most no problem product of use in the past is even used suddenly and tingles very by somebody
To playing measles, the barrier function damage of skin is all pointed out in these performances.
With advancing age with the increase of life stress, the skin aging of people can become apparent from.Skin metabolism
Slow down, intradermal Moisture factor reduce so that intradermal elastic fibers and collagen fiber hypofunction, cause skin tension,
Elastic force weakens, and making skin occur, wrinkle, skin are gloomy, lack cordiality.
The most general maintenance skin barrier and anti-aging product function are single, the two are not combined
Come.
Summary of the invention
It is an object of the invention to according to deficiency of the prior art, it is provided that one has maintenance skin barrier and anti-ageing
The substrate of old effect.
Another object of the present invention is to provide the preparation method and application of above-mentioned substrate.
The purpose of the present invention is achieved through the following technical solutions:
The invention provides a kind of substrate with maintenance skin barrier and senile-resistant efficacy, by the most by weight percent
The component composition of meter:
3%～4%1,2-pentanediol, 10%～15% methyl propanediol, 1%～2% hyaluronate sodium, 3%～5% are close
Luo Muye/stem extract, 10%～15% elastin hydrolysis, 10%～20% are containing 100～200ppm palmitoyl oligopeptides
Antidotal agent, 5%～10% tea extract, 0.2%～0.5% cell growth factor stock solution, 3%～5% are containing 45-55ppm
The neurotransmitter suppression class victory antidotal agent of peptide, 5%～10% algae extract * and excess water；
The density of described cell growth factor stock solution is 0.90-1.10g/ml, contains in described cell growth factor stock solution
Oligopeptides active substance, the activity of described oligopeptides active substance > 200,000U/ml.
Inventors be surprised to learn that, can be degraded Transdermal absorption by skin by above-mentioned seven kinds of components, can be skin supply
Nutrition, by its reasonable compatibility, realizes the effect of Synergistic between each component, make the substrate made have concurrently maintenance skin barrier and
Senile-resistant efficacy.Above-mentioned substrate is added in cosmetic formulations, the maintenance skin barrier of cosmetics and anti-ageing can be obviously improved
Old effect.
Preferably, it is made up of following component by mass percentage:
4%1,2-pentanediol, 15% methyl propanediol, 2% hyaluronate sodium, 5% close Luo Mu leaf/stem extract, 15%
Elastin hydrolysis, 20% raw containing the antidotal agent of 100～200ppm palmitoyl oligopeptides, 10% tea extract, 0.5% cell
Long factor stock solution, 5% containing 45-55ppm neurotransmitter suppression class victory the antidotal agent of peptide, 10% algae extract * and
13.5% water.
It is highly preferred that described palmitoyl oligopeptide is palmityl tripeptides-1 and Palmitoyl Tetrapeptide-7；Described oligopeptides active matter
Matter is oligopeptide-3 and oligopeptide-1；Described neurotransmitter suppression class victory peptide material is acetyl group tetrapeptide-2.
There is described in present invention simultaneously provides the preparation method of the substrate of maintenance skin skin protection barrier and senile-resistant efficacy, including
Following steps:
S1. by water, 1,2-pentanediol, methyl propanediol and hyaluronate sodium Hybrid Heating, obtain sodium hyaluronate solution；
S2. by close Luo Mu leaf/stem extract, elastin hydrolysis, defying age containing 100～200ppm palmitoyl oligopeptides
Agent, tea extract, cell growth factor stock solution, the antidotal agent winning peptide containing 45-55ppm neurotransmitter suppression class and algae are extracted
Thing * adds in S1 in gained sodium hyaluronate solution, and stirring i.e. obtains described substrate after filtration.
Preferably, in S1 heating after, carry out insulated and stirred, heating-up temperature is 85～90 DEG C, temperature retention time be 30～
45min, mixing speed is 800～1000r/min.
Preferably, in S2, carrying out homogenizing after stirring, mixing speed is 800～1000r/min, mixing time be 5～
10min, homogenizing speed is 1000～1500rpm, and homogenizing time is 3～5min.
Additionally, there is the skin-protection product of the substrate of maintenance skin skin protection barrier and senile-resistant efficacy all in the present invention described in comprising
In protection domain.
Further, skin-protection product of the present invention is skin-care cosmetics, including emulsion, eye essence, astringent
And essence etc..
Present invention simultaneously provides a kind of skin-protection product, described skin-protection product includes following component group by mass percentage
Become: component A: methyl sesquistearate 0.5～1.5%, PEG-20 methyl sesquistearate 0.5～1.5%,
Polydimethylsiloxane 1.5～3%, sunflower seed oil 1～3%, isononyl isononanoate 2～4%, batilol 0.1～0.5%；
B component: glycerol 6～10%, dipropylene glycol 4～8%, 1,2-pentanediol 2～5%, carbomer 0.1～0.5%, water
45～55%；
Component C: essence 0.01～0.03%, described substrate 15～25%；
D component: triethanolamine 0.2～0.5%.
Preferably, described cosmetics include that following component by mass percentage forms:
Component A: methyl sesquistearate 1%, PEG-20 methyl sesquistearate 1%, poly dimethyl
Siloxanes 2%, Helianthi (HELIANTHUS ANNUUS) seed oil 2.0%, isononyl isononanoate 3.0%, batilol 0.3%；
B divides: glycerol 8.0%, dipropylene glycol 6%, 1,2-pentanediol 3%, carbomer 0.3%, water 53.08%；
Component C: essence 0.02%, described substrate 20%；
D component: triethanolamine 0.3%.
Close Luo Mu (MYROTHAMNUS FLABELLIFOLIA) leaf/stem extract, pH:4.5-6.0, is the master of Radix Ophiopogonis
Wanting active component, it is requisite for surviving Radix Ophiopogonis in prolonged drought environment, has potent activation and reproducibility, strengthens
Cell viability and metabolism, activating and regenerating Skin Cell, the enhancing non-oxidizability (SOD) of Skin Cell, accelerated ageing cell
The synthesis of middle I-type collagen precursor, increase skin moisture retention, elasticity and smoothness (experiment in vivo), alleviate skin rubefaction, right
Anti-erythema (experiment in vivo), accelerating wound healing and tissue repair.
Elastin hydrolysis, pH:6.0-8.0, Density:0.990-1.100, be to be hydrolyzed into by insoluble elastin laminin
Little molecular flexibility albumen, is more easily absorbed by the skin, and directly facilitates and participate in the synthesis of dermal elastin, reaches to strengthen skin bullet
Property (full) effect, increase skin corium thickness, slow down aging, make skin health flexible.
Containing the antidotal agent of 100～200ppm palmitoyl oligopeptides, active component palmitoyl oligopeptide therein is palmityl
Tripeptides-1 and Palmitoyl Tetrapeptide-7, palmityl tripeptides-1 content therein is 100ppm, and Palmitoyl Tetrapeptide-7 content is 50ppm,
PH:4.0-6.0, Density:1.140-1.160g/cm3(20 DEG C), contribute to, by rebuilding fragile papilla dermis network, subtracting
The photoaging of few skin, can reduce wrinkle, the pliability improving skin and elasticity.
Tea (CAMELLIA SINENSIS) extract, pH:4.5-7.5, Density (20 DEG C): 1.0-1.3 (g/ml).Should
Extract can remain the quantity of former bioactive molecule to greatest extent, for protecting and improve characteristic and the work of natural prodcuts
Property, promote fiber synthesis and cell regeneration, suppress aging signal.Increase the consistency of skin corium.Help to promote and repair corium
Layer function, keeps the resistance of skin.Promote that epidermis cell is constantly regenerating, strengthen the barrier protection function of skin.
Cell growth factor stock solution, wherein contains oligopeptides active substance, oligopeptides active substance be oligopeptide-3 and oligopeptide-
1, the activity of oligopeptides active substance > 200,000U/ml, pH:6.0-7.0, density: 0.90-1.10 (g/ml).To epidermis with true
The various kinds of cell of cortex has specific activation cell, promotes the various active such as cell growth, division, promotes the fibroblast of skin corium
Dimension cell synthesis and secretion collagen protein, elastic fiber albumen and substrate, strengthen skin elasticity, effectively prevents wrinkle from being formed (long
Phase use even can eliminate the shallow wrinkle of table), slowing down skin aging process.Supplement skin NMF, improve dry and soft coarse, matt,
The unsound skin such as aging, makes skin more smooth, moistening, delicate.
Containing the antidotal agent of 45-55ppm neurotransmitter suppression class victory peptide, wherein active component is acetyl group tetrapeptide-2,
The content of acetyl group tetrapeptide-2 be 45-55 (ppm), pH:6.0-8.5. can strengthen maintenance collagen level and elastic fiber just
The really natural cause of assembling, promotes that the combination of cell and ECM, antagonism cause the unfavorable work that skin firmness and adhesion are lost
With.
Algae extract *, wherein algae extract * active matter content is about 5%.The synthesis accelerating presenilin can be reduced, subtract
Few wrinkle, increases skin elasticity, to anti aging effect.
Compared with prior art, the present invention has the following advantages and beneficial effect:
The present invention can be degraded Transdermal absorption, component for skin supply nutrition by skin by seven kinds of rationally screening,
And by its reasonable compatibility, between each component, realize the effect of Synergistic, make the substrate made have maintenance skin barrier concurrently and resist
Old and feeble effect.Above-mentioned substrate is added to the cosmetic formulations such as astringent, emulsion, cream, repairing of cosmetics can be obviously improved
Protect skin barrier and senile-resistant efficacy.
Detailed description of the invention
Further illustrate the present invention below in conjunction with specific embodiment, but the present invention is not done any type of by embodiment
Limit.Unless stated otherwise, the present invention uses reagent, method and apparatus are the art conventional reagent, method and apparatus.
Unless stated otherwise, agents useful for same of the present invention and material are commercial.
Embodiment 1
1, the preparation method of a kind of substrate with maintenance skin barrier and senile-resistant efficacy, concretely comprises the following steps:
(1) 49.7% deionized water, 3%1,2-pentanediol, 10% methyl propanediol, 1% hyaluronate sodium are heated to
85 DEG C, insulated and stirred (insulation 30min stirs speed for 1000rpm), obtain sodium hyaluronate solution, be cooled to 38 DEG C.
(2) by 3% close Luo Mu (MYROTHAMNUS FLABELLIFOLIA) leaf/stem extract, 10% hydrolyzed elastin egg
In vain, 10%MATRIXYL 3000,5% tea (CAMELLIA SINENSIS) extract, 0.3% cell growth factor stock solution AGF+
KGF, 3%UPLEVITY SOLUTION, 5% algae extract * join in (1), and stirring 10min (stirs speed for 1000rpm), all
Matter 3min (homogenizing speed is 1500rpm), 200 mesh filter-cloth filtering dischargings, i.e. obtain having maintenance skin and senile-resistant efficacy
Skin matrix.
2, a kind of facial treatment milk comprising skin matrix, is made up of following component by mass percentage:
Component A: methyl sesquistearate 1%, PEG-20 methyl sesquistearate 1%, poly dimethyl
Siloxanes 2%, Helianthi (HELIANTHUS ANNUUS) seed oil 2.0%, isononyl isononanoate 3.0%, batilol 0.3%；
B divides: glycerol 8.0%, dipropylene glycol 6%, 1,2-pentanediol 3%, carbomer 0.3%, deionized water 53.08%；
Component C: essence 0.02%, above-mentioned skin matrix 20%；
D component: triethanolamine 0.3%.
Wherein component A is oil phase and emulsifying agent, and B component is aqueous phase, and component C is low temperature material, and D component is nertralizer.
A kind of preparation method of the facial treatment milk comprising skin matrix:
(1) component A is sequentially added into oil phase pot, opens stirring (rotating speed 1000rpm) and be warming up to 85 DEG C, temperature 10min；
(2) B component is added aqueous phase pot, open stirring (rotating speed 1000rpm) and be warming up to 85 DEG C, be incubated 20min, obtain
Aqueous phase mixed liquor；
(3), after aqueous phase mixed liquor being sucked emulsifying pot, emulsifying pot stirring (rotating speed is 1000rpm) is opened, slowly by oil phase
Mixed liquor sucks emulsifying pot, then keeps vacuum (-0.05Mpa) and stirs fast constant, opening outer circulation homogenizing immediately and carry out homogenizing,
Homogenizing time 5min, homogenizing speed is 3000rpm；
(4) open temperature lowering water after homogenizing completes and be cooled to 40 DEG C, add component C stirring 5min (stirring speed for 1000rpm), open
Opening interior circulation homogenizing 1min, homogenizing speed is 1500rpm；It is subsequently adding D component, stirring 15min (rotating speed is 1000rpm), 200
Mesh filter-cloth filtering discharging, obtains comprising the facial treatment milk of skin matrix.
Embodiment 2
1, the preparation method of a kind of substrate with maintenance skin barrier and senile-resistant efficacy, concretely comprises the following steps:
(1) by 31.6% deionized water, 3.5%1,2-pentanediol, 12.5% methyl propanediol, 1.5% hyaluronate sodium
It is heated to 85 DEG C, insulated and stirred (insulation 30min stirs speed for 1000rpm), obtain sodium hyaluronate solution, be cooled to 38 DEG C.
(2) by 4% close Luo Mu (MYROTHAMNUS FLABELLIFOLIA) leaf/stem extract, 12.5% hydrolyzed elastin egg
In vain, 15%MATRIXYL 3000,7.5% tea (CAMELLIA SINENSIS) extract, 0.4% cell growth factor stock solution
AGF+KGF, 4%UPLEVITY SOLUTION, 7.5% algae extract * join in (1), and (stir speed is stirring 10min
1000rpm), homogenizing 3min (homogenizing speed is 1500rpm), 200 mesh filter-cloth filtering dischargings, i.e. obtain there is maintenance skin with anti-
The skin matrix of old and feeble effect.
2, a kind of facial treatment milk comprising skin matrix, is made up of following component by mass percentage:
Component A: methyl sesquistearate 1%, PEG-20 methyl sesquistearate 1%, poly dimethyl
Siloxanes 2%, Helianthi (HELIANTHUS ANNUUS) seed oil 2.0%, isononyl isononanoate 3.0%, batilol 0.3%；
B divides: glycerol 8.0%, dipropylene glycol 6%, 1,2-pentanediol 3%, carbomer 0.3%, deionized water 53.08%；
Component C: essence 0.02%, above-mentioned skin matrix 20%；
D component: triethanolamine 0.3%.
A kind of preparation method of the facial treatment milk comprising skin matrix:
(1) component A is sequentially added into oil phase pot, opens stirring (rotating speed 1000rpm) and be warming up to 85 DEG C, temperature 10min；
(2) B component is added aqueous phase pot, open stirring (rotating speed 1000rpm) and be warming up to 85 DEG C, be incubated 20min, obtain
Aqueous phase mixed liquor；
(3), after aqueous phase mixed liquor being sucked emulsifying pot, emulsifying pot stirring (rotating speed is 1000rpm) is opened, slowly by oil phase
Mixed liquor sucks emulsifying pot, then keeps vacuum (-0.05Mpa) and stirs fast constant, opening outer circulation homogenizing immediately and carry out homogenizing,
Homogenizing time 5min, homogenizing speed is 3000rpm；
(4) open temperature lowering water after homogenizing completes and be cooled to 40 DEG C, add component C stirring 5min (stirring speed for 1000rpm), open
Opening interior circulation homogenizing 1min, homogenizing speed is 1500rpm；It is subsequently adding D component, stirring 15min (rotating speed is 1000rpm), 200
Mesh filter-cloth filtering discharging, obtains comprising the facial treatment milk of skin matrix.
Embodiment 3
1, the preparation method of a kind of substrate with maintenance skin barrier and senile-resistant efficacy, concretely comprises the following steps:
(1) 13.5% deionized water, 4%1,2-pentanediol, 15% methyl propanediol, 2% hyaluronate sodium are heated to
85 DEG C, insulated and stirred (insulation 30min stirs speed for 1000rpm), obtain sodium hyaluronate solution, be cooled to 38 DEG C.
(2) by 5% close Luo Mu (MYROTHAMNUS FLABELLIFOLIA) leaf/stem extract, 15% hydrolyzed elastin egg
In vain, 20%MATRIXYL 3000,10% tea (CAMELLIA SINENSIS) extract, 0.5% cell growth factor stock solution AGF
+ KGF, 5%UPLEVITY SOLUTION, 10% algae extract * join in (1), and stirring 10min (stirs speed for 1000rpm),
Homogenizing 3min (homogenizing speed is 1500rpm), 200 mesh filter-cloth filtering dischargings, i.e. obtain that there is maintenance skin and senile-resistant efficacy
Skin matrix.
2, a kind of facial treatment milk comprising skin matrix, is made up of following component by mass percentage:
Component A: methyl sesquistearate 1%, PEG-20 methyl sesquistearate 1%, poly dimethyl
Siloxanes 2%, Helianthi (HELIANTHUS ANNUUS) seed oil 2.0%, isononyl isononanoate 3.0%, batilol 0.3%；
B divides: glycerol 8.0%, dipropylene glycol 6%, 1,2-pentanediol 3%, carbomer 0.3%, deionized water 53.08%；
Component C: essence 0.02%, above-mentioned skin matrix 20%；
D component: triethanolamine 0.3%.
A kind of preparation method of the facial treatment milk comprising skin matrix:
(1) component A is sequentially added into oil phase pot, opens stirring (rotating speed 1000rpm) and be warming up to 85 DEG C, be incubated 10min；
(2) B component is added aqueous phase pot, open stirring (rotating speed 1000rpm) and be warming up to 85 DEG C, be incubated 20min, obtain
Aqueous phase mixed liquor；
(3), after aqueous phase mixed liquor being sucked emulsifying pot, emulsifying pot stirring (rotating speed is 1000rpm) is opened, slowly by oil phase
Mixed liquor sucks emulsifying pot, then keeps vacuum (-0.05Mpa) and stirs fast constant, opening outer circulation homogenizing immediately and carry out homogenizing,
Homogenizing time 5min, homogenizing speed is 3000rpm；
(4) open temperature lowering water after homogenizing completes and be cooled to 40 DEG C, add component C stirring 5min (stirring speed for 1000rpm), open
Opening interior circulation homogenizing 1min, homogenizing speed is 1500rpm；It is subsequently adding D component, stirring 15min (rotating speed is 1000rpm), 200
Mesh filter-cloth filtering discharging, obtains comprising the facial treatment milk of skin matrix.
Comparative example 1:
A kind of substrate with maintenance skin barrier and senile-resistant efficacy, is made up of following component: 18.5% deionization
Water, 4%1,2-pentanediol, 15% methyl propanediol, 2% hyaluronate sodium, 15% elastin hydrolysis, 20%MATRIXYL
3000,10% tea (CAMELLIA SINENSIS) extract, 0.5% cell growth factor stock solution AGF+KGF, 5%UPLEVITY
SOLUTION, 10% algae extract *；Its preparation method is with the preparation method of skin matrix in embodiment 1；
A kind of facial treatment milk (i.e. comprising the cosmetics of skin matrix) comprising skin matrix, by following by mass percentage
The composition of meter: matrix components is the substrate of comparative example 1, and remaining each component and content are with emulsion in embodiment 1；Its preparation method
With the preparation method of emulsion in embodiment 1.
Comparative example 2:
A kind of substrate with maintenance skin barrier and senile-resistant efficacy, is made up of following component: 28.5% deionization
Water, 4%1,2-pentanediol, 15% methyl propanediol, 2% hyaluronate sodium, 5% close Luo Mu
(MYROTHAMNUSFLABELLIFOLIA) leaf/stem extract, 20%MATRIXYL 3000,10% tea (CAMELLIA
SINENSIS) extract, 0.5 part of cell growth factor stock solution AGF+KGF, 5%UPLEVITY SOLUTION, 10% algae are extracted
Thing *；Its preparation method is with the preparation method of skin matrix in embodiment 1；
A kind of facial treatment milk (i.e. comprising the cosmetics of skin matrix) comprising skin matrix, by following by mass percentage
The composition of meter: matrix components is the substrate of comparative example 2, and remaining each component and content are with emulsion in embodiment 1；Its preparation method
With the preparation method of emulsion in embodiment 1.
Comparative example 3:
A kind of substrate with maintenance skin barrier and senile-resistant efficacy, is made up of following component: 33.5% deionization
Water, 4%1,2-pentanediol, 15% methyl propanediol, 2% hyaluronate sodium, 5% close Luo Mu (MYROTHAMNUS
FLABELLIFOLIA) leaf/stem extract, 15% elastin hydrolysis, 10% tea (CAMELLIA SINENSIS) extract,
0.5% cell growth factor stock solution AGF+KGF, 5%UPLEVITY SOLUTION, 10% algae extract *；Its preparation method is same
The preparation method of skin matrix in embodiment 1；
A kind of facial treatment milk (i.e. comprising the cosmetics of skin matrix) comprising skin matrix, by following by mass percentage
The composition of meter: matrix components is the substrate of comparative example 3, and remaining each component and content are with emulsion in embodiment 1；Its preparation method
With the preparation method of emulsion in embodiment 1.
Comparative example 4:
A kind of substrate with maintenance skin barrier and senile-resistant efficacy, is made up of following component: 23.5% deionization
Water, 4%1,2-pentanediol, 15% methyl propanediol, 2% hyaluronate sodium, 5% close Luo Mu (MYROTHAMNUS
FLABELLIFOLIA) leaf/stem extract, 15% elastin hydrolysis, 3000,0.5 part of cell growth factor of 20%MATRIXYL
Sub-stock solution AGF+KGF, 5%UPLEVITY SOLUTION, 10% algae extract *；Its preparation method is with skin protection base in embodiment 1
The preparation method of matter；
A kind of facial treatment milk (i.e. comprising the cosmetics of skin matrix) comprising skin matrix, by following by mass percentage
The composition of meter: matrix components is the substrate of comparative example 4, and remaining each component and content are with emulsion in embodiment 1；Its preparation method
With the preparation method of emulsion in embodiment 1.
Comparative example 5:
A kind of substrate with maintenance skin barrier and senile-resistant efficacy, is made up of following component: 14% deionized water,
4%1,2-pentanediol, 15% methyl propanediol, 2% hyaluronate sodium, 5% close Luo Mu (MYROTHAMNUS
FLABELLIFOLIA) leaf/stem extract, 15% elastin hydrolysis, 20%MATRIXYL 3000,10% tea (CAMELLIA
SINENSIS) extract, 5%UPLEVITY SOLUTION, 10% algae extract *；Its preparation method is with skin protection in embodiment 1
The preparation method of substrate；
A kind of facial treatment milk (i.e. comprising the cosmetics of skin matrix) comprising skin matrix, by following by mass percentage
The composition of meter: matrix components is the substrate of comparative example 5, and remaining each component and content are with emulsion in embodiment 1；Its preparation method
With the preparation method of emulsion in embodiment 1.
Comparative example 6:
A kind of substrate with maintenance skin barrier and senile-resistant efficacy, is made up of following component: 18.5% deionization
Water, 4%1,2-pentanediol, 15% methyl propanediol, 2% hyaluronate sodium, 5% close Luo Mu (MYROTHAMNUS
FLABELLIFOLIA) leaf/stem extract, 15% elastin hydrolysis, 20%MATRIXYL 3000,10% tea (CAMELLIA
SINENSIS) extract, 0.5% cell growth factor stock solution AGF+KGF, 10% algae extract *；The same embodiment of its preparation method
The preparation method of skin matrix in 1；
A kind of facial treatment milk (i.e. comprising the cosmetics of skin matrix) comprising skin matrix, by following by mass percentage
The composition of meter: matrix components is the substrate of comparative example 6, and remaining each component and content are with emulsion in embodiment 1；Its preparation method
With the preparation method of emulsion in embodiment 1.
Comparative example 7:
A kind of substrate with maintenance skin barrier and senile-resistant efficacy, is made up of following component: 23.5% deionization
Water, 4%1,2-pentanediol, 15% methyl propanediol, 2% hyaluronate sodium, 5% close Luo Mu (MYROTHAMNUS
FLABELLIFOLIA) leaf/stem extract, 15% elastin hydrolysis, 20%MATRIXYL 3000,10% tea (CAMELLIA
SINENSIS) extract, 0.5% cell growth factor stock solution AGF+KGF, 5%UPLEVITY SOLUTION,；Its preparation method
With the preparation method of skin matrix in embodiment 1；
A kind of facial treatment milk (i.e. comprising the cosmetics of skin matrix) comprising skin matrix, by following by mass percentage
The composition of meter: matrix components is the substrate of comparative example 7, and remaining each component and content are with emulsion in embodiment 1；Its preparation method
With the preparation method of emulsion in embodiment 1.
Compliance test result:
A kind of facial treatment milk (i.e. comprising the cosmetics of skin matrix) trial effect test comprising skin matrix:
Tested crowd: 40 adult female volunteers, the age is between 30-40 one full year of life；
Test method: every day uses the skin matrix of embodiment 1-3, embodiment 1-3 to prepare at face after face cleaning sooner or later
The skin matrix of facial treatment milk, comparative example 1～7 preparation and emulsion；Survey with Tewameter TM300 after persistently using 2 weeks and 4 weeks
The TEWL value at amount cheek position, the TEWL of benchmark is under the lossless state of xerosis cutis, at ambient temperature 21 degree, ambient humidity
Measure under the state of 50%.TEWL has well reacted the integrity of skin barrier function, and TEWL value raises, it is meant that skin
Skin moisture distributes increase, and on the contrary, TEWL value reduces, then prompting barrier has obtained maintenance.Its test result is as shown in table 1.
Table 1
From test result it can be seen that the effect of skin matrix prepared by embodiment 1～3 and facial treatment milk is best,
TEWL value reduces at most, and skin barrier maintenance obtains best, and after 1 week, skin barrier is improved, and after 2 weeks, skin barrier improves
Become apparent from；The substrate effect of comparative example 1-7 is more a lot of than the substrate weak effect of embodiment；Wherein with the addition of complete in skin matrix
Portion's composition (Mi Luomu (MYROTHAMNUS FLABELLIFOLIA) leaf/stem extract, elastin hydrolysis, MATRIXYL
3000, tea (CAMELLIA SINENSIS) extract, cell growth factor stock solution AGF+KGF, UPLEVITY SOLUTION)
Embodiment 1-3 effect is substantially good than the effect of comparative example 1～7, and therefore, in described skin matrix, each composition is at maintenance skin screen
Barrier aspect has the most collaborative effect and obtains preferable effect.
A kind of facial treatment milk (i.e. comprising the cosmetics of skin matrix) trial effect test comprising skin matrix:
Tested crowd: 40 adult female volunteers, the age is between 40-50 one full year of life；
Test method: every day uses the skin matrix of embodiment 1-3, embodiment 1-3 to prepare at eye after face cleaning sooner or later
The skin matrix of facial treatment milk, comparative example 1～7 preparation and emulsion；VISIA instrument, assessment canthus fish tail is used after using 4 weeks continuously
Stricture of vagina district wrinkle area, wrinkle quantity, the minimizing degree of wrinkle depth, its test result is as shown in table 2.
Table 2
| Wrinkle area reduction | Wrinkle quantity decrement | Wrinkle depth decrement | |
| The skin matrix of embodiment 1 | 28.2% | 27.6% | 28.3% |
| The skin matrix of embodiment 2 | 31.2% | 32.5% | 32.2% |
| The skin matrix of embodiment 3 | 30.7% | 30.3% | 29.8% |
| The skin matrix of comparative example 1 | 23.6% | 20.9% | 21.8% |
| The skin matrix of comparative example 2 | 10.1% | 9.9% | 9.6% |
| The skin matrix of comparative example 3 | 13.5% | 133% | 12.8% |
| The skin matrix of comparative example 4 | 16.2% | 15.8% | 15.8% |
| The skin matrix of comparative example 5 | 13.8% | 14.2% | 13.7% |
| The skin matrix of comparative example 6 | 17.2% | 18.9% | 17.5% |
| The skin matrix of comparative example 7 | 17.6% | 16.9% | 17.3% |
| The facial treatment milk of embodiment 1 | 24.5% | 24.9% | 25.1% |
| The facial treatment milk of embodiment 2 | 27.6% | 27.8% | 26.5% |
| The facial treatment milk of embodiment 3 | 33.1% | 34.2% | 34.6% |
| The facial treatment milk of comparative example 3 | 19.7% | 17.6% | 16.3% |
| The facial treatment milk of comparative example 4 | 20.2% | 19.6% | 18.9% |
| The facial treatment milk of comparative example 5 | 16.5% | 16.9% | 17.2% |
| The facial treatment milk of comparative example 6 | 21.2% | 21.8% | 20.9% |
| The facial treatment milk of comparative example 7 | 17.9% | 17.6% | 17.8% |
From test result it can be seen that the effect of skin matrix prepared by embodiment 1～3 and facial treatment milk is best, wrinkle
Stricture of vagina area, wrinkle quantity, wrinkle depth reduce at most；Whole composition (Mi Luomu is with the addition of in skin matrix
(MYROTHAMNUS FLABELLIFOLIA) leaf/stem extract, elastin hydrolysis, MATRIXYL 3000, tea (CAMELLIA
SINENSIS) extract, cell growth factor stock solution AGF+KGF, UPLEVITY SOLUTION, embodiment 1-of algae extract *
3 effects are better than the effect of comparative example 1～7, and therefore, in described skin matrix, each composition has the most collaborative in terms of defying age
Effect and obtain preferable effect.
Above-described embodiment is the present invention preferably embodiment, but embodiments of the present invention are not by above-described embodiment
Limit, the change made under other any spirit without departing from the present invention and principle, modify, substitute, combine, simplify,
All should be the substitute mode of equivalence, within being included in protection scope of the present invention.
Claims (10)
1. a substrate with maintenance skin barrier and senile-resistant efficacy, it is characterised in that by the most by mass percentage
Component composition:
3%～4% 1,2-pentanediol, 10%～15% methyl propanediol, 1%～2% hyaluronate sodium, 3%～5% close Luo Mu leaf/stem
Extract, 10%～15% elastin hydrolysis, 10%～20% antidotal agent containing 100 ~ 200ppm palmitoyl oligopeptide, 5%～
10% tea extract, 0.2%～0.5% cell growth factor stock solution, 3%～5% are containing 45-55ppm neurotransmitter suppression class victory peptide
Antidotal agent, 5%～10% algae extract * and excess water；
The density of described cell growth factor stock solution is 0.90-1.10g/ml, containing oligopeptide in described cell growth factor stock solution
Class active substance, the activity of described oligopeptides active substance > 200,000 U/ml.
The most according to claim 1, there is the substrate of maintenance skin barrier and senile-resistant efficacy, it is characterised in that by pressing as follows
The component composition of mass percentage:
4% 1,2-pentanediol, 15% methyl propanediol, 2% hyaluronate sodium, 5% close Luo Mu leaf/stem extract, 15% hydrolysis bullet
Property albumen, 20% former containing the antidotal agent of 100 ~ 200ppm palmitoyl oligopeptide, 10% tea extract, 0.5% cell growth factor
Liquid, 5% containing 45-55ppm neurotransmitter suppression class victory the antidotal agent of peptide, 10% algae extract * and 13.5% water.
The most according to claim 1, there is the substrate of maintenance skin barrier and senile-resistant efficacy, it is characterised in that described Petiolus Trachycarpi
Acyl oligopeptide is palmityl tripeptides-1 and Palmitoyl Tetrapeptide-7；Described oligopeptides active substance is oligopeptide-3 and oligopeptide-1；Described god
It is acetyl group tetrapeptide-2 through mediator suppression class victory peptide material.
4. there is described in claim 1 preparation method for the substrate of maintenance skin skin protection barrier and senile-resistant efficacy, its feature
It is, comprises the steps:
S1. by water, 1,2-pentanediol, methyl propanediol and hyaluronate sodium Hybrid Heating, obtain sodium hyaluronate solution；
S2. by close Luo Mu leaf/stem extract, elastin hydrolysis, the antidotal agent containing 100 ~ 200ppm palmitoyl oligopeptide, tea
Extract, cell growth factor stock solution, the antidotal agent winning peptide containing 45-55ppm neurotransmitter suppression class and algae extract * add
Enter in S1 in gained sodium hyaluronate solution, stirring, i.e. obtain described substrate after filtration.
Preparation method the most according to claim 4, it is characterised in that in S1, heating-up temperature is 85～90 DEG C, after heating, enters
Row insulated and stirred, temperature retention time is 30～45min, and mixing speed is 800～1000r/min.
Preparation method the most according to claim 4, it is characterised in that in S2, carries out homogenizing after stirring, mixing speed is
800～1000r/min, mixing time is 5～10min, and homogenizing speed is 1000～1500rpm, and homogenizing time is 3～5min.
7. claims 1 to 3 arbitrary described in there is the substrate of maintenance skin barrier and senile-resistant efficacy in preparing skin-protection product
Application.
8. a skin-protection product, it is characterised in that include that claims 1 to 3 has maintenance skin skin protection barrier with anti-described in arbitrary
The substrate of old and feeble effect.
Skin-protection product the most according to claim 8, it is characterised in that there is maintenance skin skin protection barrier and defying age by described
The substrate of effect joins in skin-protection product according to the mass percent of 15 ~ 25%.
Skin-protection product the most according to claim 9, it is characterised in that include following component group by mass percentage
Become:
Component A: methyl sesquistearate 0.5 ~ 1.5%, PEG-20 methyl sesquistearate 0.5 ~ 1.5%, poly-
Dimethyl siloxane 1.5 ~ 3%, sunflower seed oil 1 ~ 3%, isononyl isononanoate 2 ~ 4%, batilol 0.1 ~ 0.5%；
B component: glycerol 6 ~ 10%, dipropylene glycol 4 ~ 8%, 1,2-pentanediol 2 ~ 5%, carbomer 0.1 ~ 0.5%, water 45 ~ 55%；
Component C: essence 0.01 ~ 0.03%, described substrate 15 ~ 25%；
D component: triethanolamine 0.2 ~ 0.5%.
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