CN114712275B - Anti-wrinkle repair composition and preparation method thereof, and cosmetics and preparation method thereof - Google Patents
Anti-wrinkle repair composition and preparation method thereof, and cosmetics and preparation method thereof Download PDFInfo
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- CN114712275B CN114712275B CN202210146285.4A CN202210146285A CN114712275B CN 114712275 B CN114712275 B CN 114712275B CN 202210146285 A CN202210146285 A CN 202210146285A CN 114712275 B CN114712275 B CN 114712275B
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/925—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of animal origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9706—Algae
- A61K8/9722—Chlorophycota or Chlorophyta [green algae], e.g. Chlorella
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Dermatology (AREA)
- Zoology (AREA)
- Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Cosmetics (AREA)
Abstract
An anti-wrinkle repair composition and a preparation method thereof, and a cosmetic and a preparation method thereof relate to the technical field of cosmetics; comprising the following steps: 10-20 parts of hydrolyzed elastin, 10-15 parts of Abelmoschus manihot extract, 1-8 parts of Mirabilis jalapa extract, 5-10 parts of Chlorella extract, 0.2-1 part of cytokine stock solution, 0.1-2 parts of sodium hyaluronate, 2-10 parts of propylene glycol and 25-50 parts of water. Through reasonable compatibility, the components of the application realize synergistic interaction, can be degraded and absorbed by skin, can supply nutrition to skin, has the function of scavenging free radicals, can prevent cell degradation and aging, can effectively repair skin injury, can provide nutrition for skin, and can improve skin elasticity and brightness.
Description
Technical Field
The application belongs to the technical field of cosmetics, and particularly relates to an anti-wrinkle repair composition and a preparation method thereof, and a cosmetic and a preparation method thereof.
Background
With the increase of environmental pollution and living pressure, the skin aging condition of people is more and more serious. Environmental factors, seasonal changes, irritation of facial care products, and use of hormonal cosmetics cause damage to the skin to varying degrees.
With the aging, the number of fibroblasts in the human body gradually decreases, so that the secreted collagen and elastin are gradually reduced and broken due to oxidation, the dermis layer begins to be thinned, the skin elasticity becomes poor, and wrinkles also begin to be generated gradually. When collagen of the dermis layer is oxidized and broken, supporting effect on the epidermis is reduced, thus causing heterogeneous collapse, thereby wrinkling. The human body has an enzyme called SOD, which is a substance for removing free radical garbage in the human body. With the increase of age, SOD activity gradually weakens, and in-vivo garbage is difficult to remove, so that garbage generated by free radicals is a toxic substance and is a harmful substance causing human body aging. The cosmetics containing free radical removal and antioxidation are used for nursing, so that the occurrence of skin wrinkles can be delayed to a certain extent, and the skin can keep elasticity and fineness; however, due to skin damage caused by environmental factors, the absorption of effective components by skin is reduced, the anti-wrinkle effect is low, and cosmetics with anti-wrinkle and repairing effects on skin are not common in the market.
Disclosure of Invention
In order to overcome the defects of the prior art, one of the purposes of the application is to provide an anti-wrinkle repair composition which has strong functions of resisting oxidization and scavenging free radicals, can prevent cell degradation and aging, can effectively repair skin injury, provide nutrition for skin, and improve skin elasticity and brightness.
The second purpose of the application is to provide a preparation method of the anti-wrinkle repair composition, which is simple and easy to operate.
The application further aims to provide an anti-wrinkle repair cosmetic which has good anti-wrinkle and repair effects and stable performance.
The fourth purpose of the application is to provide a preparation method of the anti-wrinkle repair cosmetic, which is simple, easy to operate and suitable for mass production.
One of the purposes of the application is realized by adopting the following technical scheme:
an anti-wrinkle repair composition comprises the following components in parts by mass:
10-20 parts of hydrolyzed elastin, 10-15 parts of Abelmoschus manihot extract, 1-8 parts of Mirabilis jalapa extract, 5-10 parts of Chlorella extract, 0.2-1 part of cytokine stock solution, 0.1-2 parts of sodium hyaluronate, 2-10 parts of propylene glycol and 25-50 parts of water.
Further, 15-20 parts of hydrolyzed elastin, 7-12 parts of Abelmoschus manihot extract, 3-6 parts of Mirabilis jalapa extract, 2-5 parts of Mirabilis Luo Mushe/stem extract, 5-8 parts of chlorella extract, 0.4-0.8 part of cytokine stock solution, 0.1-1 part of sodium hyaluronate, 3-5 parts of propylene glycol and 25-35 parts of water.
Further, the cytokine stock solution comprises oligopeptide active matters, wherein the oligopeptide active matters comprise oligopeptide-3 and oligopeptide-1, the molecular weight of the oligopeptide active matters is 15-20kD, and the activity is more than 200000U/ml.
The second purpose of the application is realized by adopting the following technical scheme:
a preparation method of the anti-wrinkle repair composition comprises the following steps:
1) Uniformly mixing water, propylene glycol and sodium hyaluronate, heating, preserving heat, and cooling to obtain a mixed solution;
2) Adding hydrolyzed elastin, abelmoschus manihot extract, mirabilis jalapa Luo Mushe/stem extract, chlorella extract and cytokine stock solution into the mixed solution, stirring, and homogenizing to obtain anti-wrinkle repairing composition.
Further, in the step 1), the heating temperature is 60-80 ℃, the heat preservation time is 20-30min, and the cooling temperature is 30-45 ℃;
in the step 2), the stirring speed is 500-700r/min, and the stirring time is 5-15min.
The third purpose of the application is realized by adopting the following technical scheme:
an anti-wrinkle repair cosmetic comprising the anti-wrinkle repair composition.
Further, the composition comprises the following components in parts by mass:
25-40 parts of anti-wrinkle repair composition, 10-20 parts of alligator oil, 3-8 parts of jojoba seed oil, 2-5 parts of panthenol, 1-3 parts of PEG-20 methyl glucose sesquistearate, 1-3 parts of hydrogenated lecithin, 0.5-1 part of tocopheryl acetate, 0.05-0.2 part of triethanolamine, 3-5 parts of butanediol, 0.3-1.5 part of carbomer, 0.01-0.2 part of propyl hydroxybenzoate, 0.02-0.05 part of EDTA disodium, 0.01-0.03 part of essence, 4-10 parts of glycerol and 50-70 parts of water.
The fourth purpose of the application is realized by adopting the following technical scheme:
a preparation method of an anti-wrinkle repair cosmetic comprises the following steps:
s1, mixing crocodile oil, jojoba seed oil, PEG-20 methyl glucose sesquistearate, hydrogenated lecithin, tocopheryl acetate and propyl hydroxybenzoate according to a formula amount, stirring, heating to 80-90 ℃, and preserving heat to obtain an oil phase mixture for later use;
s2, mixing the water, glycerol, panthenol, butanediol, carbomer and EDTA disodium according to the formula amount, stirring, heating to 80-90 ℃, and preserving heat to obtain a water phase mixture for later use;
s3, uniformly stirring the water phase mixture, adding the oil phase mixture, stirring in vacuum, and homogenizing to obtain a homogenized emulsion A;
s4, adding triethanolamine after the temperature of the homogenized emulsion A is reduced to 55-65 ℃ and homogenizing to obtain homogenized emulsion B;
s5, after the temperature of the homogenized emulsion B is reduced to 40-45 ℃, adding the anti-wrinkle repair composition and essence according to the formula amount, uniformly stirring, and homogenizing to obtain the anti-wrinkle repair cosmetic.
Further, in the step S3, the vacuum stirring speed is 400-600r/min, and the vacuum degree is-0.05 to-0.07 MPa.
Further, the method comprises the following steps: in the step S1, the heat preservation time is 10-20min, and the stirring speed is 900-1100r/min;
in the step S2, the heat preservation time is 15-25min, and the stirring speed is 900-1100r/min;
in step S3, the homogenizing speed is 2000-3000r/min
In the step S4, the homogenizing speed is 2000-3000r/min;
in the step S5, the stirring speed is 400-600r/min, and the homogenizing speed is 2000-3000r/min.
Chlorella extract is rich in various cell active substances including nucleic acid, polysaccharide, polypeptide, fatty acid, enzyme, etc., and these components constitute its specific C.G.F (cell regeneration factor), and after being absorbed transdermally, the C.G.F has powerful capacity of repairing damaged cell and DNA damage and raised skin cell activity.
Abelmoschus manihot extract has antioxidant, inflammatory factor inhibiting, and skin immunocyte improving effects; the active ingredient of the skin care cream is flavone, has good moisturizing effect, can supplement moisture and nutrients for skin, and enables the skin to be moist and full, so that fine lines are smoothed, wrinkles are reduced or lightened, and the skin care cream has the effect of removing wrinkles; the efficacy of flavone is multiple-sided, on one hand, it is a very strong antioxidant, can dispel the oxygen free radical in vivo effectively; on the other hand, can inhibit exudation of inflammatory biological enzyme, promote wound healing and relieve pain.
The hydrolyzed elastin is derived from Atlantic swallow fish skin, has small molecular weight, can promote the skin to fully absorb, increase the content of skin collagen and elastin, obviously improve the internal tension and elasticity of the skin, strengthen the collagen activity of the skin, keep the moisture of cutin, improve and reduce wrinkles from inside to outside, improve the sense of tightness and increase the skin elasticity so as to delay the efficacy of aging.
The cell factor stock solution is rich in oligopeptide components, improves unhealthy skin conditions such as dry and loose, matt, aging and the like, makes skin smoother, moist and tender, increases skin elasticity, and effectively prevents wrinkles from forming; has the effects of repairing various skin injuries or wounds with high efficiency, and reducing or preventing scar formation.
The Mirabilis jalapa extract is an active plant cell, the quantity of original active molecules is reserved to the maximum extent, the natural product characteristics and activities are protected, improved and enhanced, the biological clock of the skin is regulated, and the operation of the skin regeneration and repair process is improved by enhancing the activities of the main metabolic mechanism at night.
The extract of Mi Luo Mushe/stem is the main active ingredient of the dead grass, which is essential for the survival of the dead grass in a long-term drought environment; the application has strong activating and regenerating properties, can increase the elasticity and moisture retention of skin, lighten skin redness, resist erythema, strengthen the activity and metabolism of skin cells, recover aged cells to a young cell state, and activate and regenerate skin.
Panthenol, also called provitamin B5, is a vitamin precursor, which can play a role in moisturizing and repairing skin by promoting the synthesis of coenzyme a, is absorbed by skin, can increase the content of hyaluronic acid in skin, and promotes the metabolism of human proteins, saccharides and fat.
Sodium hyaluronate has excellent moisturizing effect, has very strong water absorption capacity and is a recognized natural moisturizing factor. Meanwhile, the small molecular sodium hyaluronate can penetrate into the epidermis layer of the skin, and promote the supply of skin nutrition and the excretion of waste, thereby preventing skin aging and playing a certain role in maintaining beauty and keeping young. In addition, sodium hyaluronate has the effect of promoting repair of skin injury, and can promote regeneration of epidermal cells by promoting proliferation and differentiation of epidermal cells, thereby promoting healing of skin at the injured part.
Crocodile oil has effects of repairing, removing speckle, resisting aging, resisting bacteria and diminishing inflammation. It contains abundant unsaturated fatty acids. Has good penetrating power in skin, and can carry medicinal components to deep layer of skin to promote skin absorption. The crocodile oil contains a powerful repairing component, has the functions of activating blood circulation to remove blood stasis, activating cell regeneration, accelerating metabolism and promoting the skin cells to accelerate the alternation of new and old after penetrating into the skin. Meanwhile, the crocodile oil has good effect on the aspect of treating wounds, and has obvious repairing effect on scars formed by scalds, burns and sunburn. In addition, the crocodile oil also contains specific crocodile enzyme, stimulates human immune cells to generate antibodies, improves the immune function, engulfs germ and virus and reduces skin infection.
Compared with the prior art, the application has the beneficial effects that:
the application relates to an anti-wrinkle repair composition, which comprises hydrolyzed elastin, a golden flower extract, a mirabilis jalapa extract, a dense Luo Mushe/stem extract, a chlorella extract, a cytokine stock solution and sodium hyaluronate; the hydrolyzed elastin can strengthen collagen activity of skin, reduce wrinkles, improve tightness and increase skin elasticity; abelmoschus manihot extract is rich in flavone, and has antioxidant and inflammatory factor inhibiting effects; the Mirabilis jalapa extract and Mirabilis jalapa flower/stem extract have strong activating and regenerating effects, and can increase skin elasticity and moisture retention, and enhance skin cell activity and metabolism; chlorella extract contains cell regeneration factor, and has effect in repairing damaged cell and DNA injury; the cell factor stock solution is rich in oligopeptide, so that the cell growth is promoted; sodium hyaluronate has effects of keeping moisture, resisting oxidation and repairing simultaneously; through reasonable compatibility, the components realize synergistic effect, can be degraded and absorbed by skin in a transdermal way, can supply nutrition to the skin, remove free radicals, prevent cell degradation and aging, effectively repair skin injury, provide nutrition to the skin, and improve skin elasticity and brightness.
The preparation method of the anti-wrinkle repair composition is simple, easy to operate and stable in performance.
The anti-wrinkle repair cosmetic provided by the application is matched with other moisturizing components by adopting an anti-wrinkle repair composition, can supply nutrition to skin, has the function of scavenging free radicals, can prevent cell degradation and aging, and can effectively repair skin injury; the crocodile oil is adopted to improve the permeability, so that the anti-wrinkle repair composition can be carried to the deep layer of the skin, can supply nutrition to the skin, activate the cell regeneration function and realize the effect of anti-wrinkle repair.
The preparation method of the anti-wrinkle repair cosmetic is simple, easy to operate and capable of realizing batch standardized production.
Detailed Description
The present application will be further described with reference to the following specific embodiments, and it should be noted that, on the premise of no conflict, new embodiments may be formed by any combination of the embodiments or technical features described below.
The reagents and materials used in the present application are commercially available unless otherwise specified. Among them, hydrolyzed Elastin is purchased from Italian I.R.A. (trade name: elastin Marina); abelmoschus manihot extract was purchased from Kang Pulai St. Biol; mirabilis jalapa extract, purchased from Naolys company, france (trade name Overnight Enhance [ MJ+C ] S-Gly); the Mi Luo Mushe/stem extract is purchased from bitop AG (trade name GLYCOIN NATURAL); chlorella extract was purchased from Feng He biological company; crocodile oil is purchased from sandy Ji Ya company; cytokine stock solutions were purchased from start point company.
Example 1
An anti-wrinkle repair composition comprises the following components in parts by mass:
18 parts of hydrolyzed elastin, 10 parts of Abelmoschus manihot extract, 4 parts of Mirabilis jalapa extract, 4 parts of Mirabilis Luo Mushe/stem extract, 6 parts of chlorella extract, 0.6 part of cytokine stock solution, 0.5 part of sodium hyaluronate, 4 parts of propylene glycol and 30 parts of water.
The cytokine stock solution comprises oligopeptide active matters, wherein the oligopeptide active matters comprise oligopeptide-3 and oligopeptide-1, the molecular weight of the oligopeptide active matters is 15-20kD, and the activity is more than 200000U/ml.
A preparation method of the anti-wrinkle repair composition comprises the following steps:
1) Uniformly mixing water, propylene glycol and sodium hyaluronate, heating, preserving heat, and cooling to obtain a mixed solution; wherein the heating temperature is 70 ℃, the heat preservation time is 25min, and the cooling temperature is 38 ℃;
2) Adding hydrolyzed elastin, abelmoschus manihot extract, mirabilis jalapa extract, chlorella extract and cytokine stock solution into the mixed solution, stirring, and homogenizing to obtain anti-wrinkle repairing composition, wherein the stirring speed is 600r/min, and the stirring time is 10min.
Example 2
An anti-wrinkle repair composition comprises the following components in parts by mass:
15 parts of hydrolyzed elastin, 7 parts of Abelmoschus manihot extract, 3 parts of Mirabilis jalapa extract, 2 parts of Mirabilis Luo Mushe/stem extract, 5 parts of chlorella extract, 0.4 part of cytokine stock solution, 0.1 part of sodium hyaluronate, 3 parts of propylene glycol and 25 parts of water.
A preparation method of the anti-wrinkle repair composition comprises the following steps:
1) Uniformly mixing water, propylene glycol and sodium hyaluronate, heating, preserving heat, and cooling to obtain a mixed solution; wherein the heating temperature is 60 ℃, the heat preservation time is 30min, and the cooling temperature is 30 ℃;
2) Adding hydrolyzed elastin, abelmoschus manihot extract, mirabilis jalapa extract, chlorella extract and cytokine stock solution into the mixed solution, stirring, and homogenizing to obtain anti-wrinkle repairing composition, wherein the stirring speed is 500r/min, and the stirring time is 5min.
Example 3
An anti-wrinkle repair composition comprises the following components in parts by mass:
20 parts of hydrolyzed elastin, 12 parts of Abelmoschus manihot extract, 6 parts of Mirabilis jalapa extract, 5 parts of Mirabilis Luo Mushe/stem extract, 8 parts of chlorella extract, 0.8 part of cytokine stock solution, 1 part of sodium hyaluronate, 5 parts of propylene glycol and 35 parts of water.
A preparation method of the anti-wrinkle repair composition comprises the following steps:
1) Uniformly mixing water, propylene glycol and sodium hyaluronate, heating, preserving heat, and cooling to obtain a mixed solution; wherein the heating temperature is 80 ℃, the heat preservation time is 20min, and the cooling temperature is 45 ℃;
2) Adding hydrolyzed elastin, abelmoschus manihot extract, mirabilis jalapa extract, chlorella extract and cytokine stock solution into the mixed solution, stirring, and homogenizing to obtain anti-wrinkle repairing composition, wherein the stirring speed is 700r/min, and the stirring time is 15min.
Example 4
An anti-wrinkle repair cosmetic comprises an anti-wrinkle repair composition of example 1, and specifically comprises the following components in parts by mass:
30 parts of an anti-wrinkle repair composition, 15 parts of crocodile oil, 5 parts of jojoba seed oil, 3 parts of panthenol, 2 parts of PEG-20 methyl glucose sesquistearate, 2 parts of hydrogenated lecithin, 0.8 part of tocopheryl acetate, 0.1 part of triethanolamine, 4 parts of butanediol, 1 part of carbomer, 0.1 part of hydroxypropyl, 0.03 part of EDTA disodium, 0.02 part of essence, 7 parts of glycerol and 60 parts of water.
A preparation method of an anti-wrinkle repair cosmetic comprises the following steps:
s1, mixing crocodile oil, jojoba seed oil, PEG-20 methyl glucose sesquistearate, hydrogenated lecithin, tocopheryl acetate and propyl hydroxybenzoate according to a formula amount, stirring, heating to 85 ℃, and preserving heat to obtain an oil phase mixture for later use; wherein the heat preservation time is 15min, and the stirring speed is 1000r/min;
s2, mixing the water, glycerol, panthenol, butanediol, carbomer and EDTA disodium according to the formula amount, stirring, heating to 85 ℃, and preserving heat to obtain a water phase mixture for later use; wherein the heat preservation time is 20min, and the stirring speed is 1000r/min;
s3, uniformly stirring the water phase mixture, adding the oil phase mixture, stirring in vacuum, and homogenizing to obtain a homogenized emulsion A; wherein the vacuum stirring speed is 500r/min, the vacuum degree is-0.06 MPa, and the homogenizing speed is 2500r/min;
s4, adding triethanolamine after the temperature of the homogenized emulsion A is reduced to 60 ℃, and homogenizing to obtain homogenized emulsion B; wherein the homogenizing speed is 2500r/min;
s5, after the temperature of the homogenized emulsion B is reduced to 42 ℃, adding the anti-wrinkle repair composition and essence according to the formula amount, uniformly stirring, and homogenizing to obtain the anti-wrinkle repair cosmetic; wherein the stirring speed is 500r/min, and the homogenizing speed is 2500r/min.
Example 5
An anti-wrinkle repair cosmetic comprises an anti-wrinkle repair composition of example 2, and specifically comprises the following components in parts by mass:
25 parts of an anti-wrinkle repair composition, 10 parts of crocodile oil, 3 parts of jojoba seed oil, 2 parts of panthenol, 1 part of PEG-20 methyl glucose sesquistearate, 1 part of hydrogenated lecithin, 0.5 part of tocopheryl acetate, 0.05 part of triethanolamine, 3 parts of butanediol, 0.3 part of carbomer, 0.01 part of propylparaben, 0.02 part of EDTA disodium, 0.01 part of essence, 4 parts of glycerol and 50 parts of water.
A preparation method of an anti-wrinkle repair cosmetic comprises the following steps:
s1, mixing crocodile oil, jojoba seed oil, PEG-20 methyl glucose sesquistearate, hydrogenated lecithin, tocopheryl acetate and propyl hydroxybenzoate according to a formula amount, stirring, heating to 80 ℃, and preserving heat to obtain an oil phase mixture for later use; wherein the heat preservation time is 20min, and the stirring speed is 900r/min;
s2, mixing the water, glycerol, panthenol, butanediol, carbomer and EDTA disodium according to the formula amount, stirring, heating to 80 ℃, and preserving heat to obtain a water phase mixture for later use; wherein the heat preservation time is 25min, and the stirring speed is 900r/min;
s3, uniformly stirring the water phase mixture, adding the oil phase mixture, stirring in vacuum, and homogenizing to obtain a homogenized emulsion A; wherein the vacuum stirring speed is 400r/min, the vacuum degree is-0.05 MPa, and the homogenizing speed is 2000r/min;
s4, adding triethanolamine after the temperature of the homogenized emulsion A is reduced to 55 ℃, and homogenizing to obtain homogenized emulsion B; wherein the homogenizing speed is 2000r/min;
s5, after the temperature of the homogenized emulsion B is reduced to 40 ℃, adding the anti-wrinkle repair composition and essence according to the formula amount, uniformly stirring, and homogenizing to obtain the anti-wrinkle repair cosmetic; wherein the stirring speed is 400r/min, and the homogenizing speed is 2000r/min.
Example 6
An anti-wrinkle repair cosmetic comprises an anti-wrinkle repair composition of example 3, and specifically comprises the following components in parts by mass:
40 parts of an anti-wrinkle repair composition, 20 parts of crocodile oil, 8 parts of jojoba seed oil, 5 parts of panthenol, 3 parts of PEG-20 methyl glucose sesquistearate, 3 parts of hydrogenated lecithin, 1 part of tocopheryl acetate, 0.2 part of triethanolamine, 5 parts of butanediol, 1.5 parts of carbomer, 0.2 part of propyl hydroxybenzoate, 0.05 part of EDTA disodium, 0.03 part of essence, 10 parts of glycerol and 70 parts of water.
A preparation method of an anti-wrinkle repair cosmetic comprises the following steps:
s1, mixing crocodile oil, jojoba seed oil, PEG-20 methyl glucose sesquistearate, hydrogenated lecithin, tocopheryl acetate and propyl hydroxybenzoate according to a formula amount, stirring, heating to 90 ℃, and preserving heat to obtain an oil phase mixture for later use; wherein the heat preservation time is 10min, and the stirring speed is 1100r/min;
s2, mixing the water, glycerol, panthenol, butanediol, carbomer and EDTA disodium according to the formula amount, stirring, heating to 90 ℃, and preserving heat to obtain a water phase mixture for later use; wherein the heat preservation time is 15min, and the stirring speed is 1100r/min;
s3, uniformly stirring the water phase mixture, adding the oil phase mixture, stirring in vacuum, and homogenizing to obtain a homogenized emulsion A; wherein the vacuum stirring speed is 600r/min, the vacuum degree is-0.07 MPa, and the homogenizing speed is 3000r/min;
s4, adding triethanolamine after the temperature of the homogenized emulsion A is reduced to 65 ℃ and homogenizing to obtain homogenized emulsion B; wherein the homogenizing speed is 3000r/min;
s5, after the temperature of the homogenized emulsion B is reduced to 45 ℃, adding the anti-wrinkle repair composition and essence according to the formula amount, uniformly stirring, and homogenizing to obtain the anti-wrinkle repair cosmetic; wherein the stirring speed is 600r/min, and the homogenizing speed is 3000r/min.
Comparative example 1
An anti-wrinkle repair cosmetic, comparative example 1 differs from example 4 in that: no Abelmoschus manihot extract was added to the anti-wrinkle repair composition of comparative example 1. The remaining amounts and preparation methods were the same as in example 4.
Comparative example 2
An anti-wrinkle repair cosmetic, comparative example 2 differs from example 4 in that: the anti-wrinkle repair composition of comparative example 2 was not added with chlorella extract. The remaining amounts and preparation methods were the same as in example 4.
Comparative example 3
An anti-wrinkle repair cosmetic, comparative example 3 differs from example 4 in that: comparative example 3 the chlorella extract of example 4 was replaced with an equivalent amount of centella extract having cell regeneration and repair effects. The remaining amounts and preparation methods were the same as in example 4.
Comparative example 4
An anti-wrinkle repair cosmetic, comparative example 4 differs from example 4 in that: comparative example 4 alligator oil from example 4 was replaced with an equivalent amount of wheat germ oil having skin metabolism promoting, moisturizing and antioxidant functions. The remaining amounts and preparation methods were the same as in example 4.
Performance testing
1. Anti-wrinkle test
Test object: 140 sensitive skin female volunteers were selected, between 25-40 years of age, and randomly assigned to 7 groups.
The test method comprises the following steps: the anti-wrinkle repair cosmetics of examples 4 to 6 and the anti-wrinkle repair cosmetics of comparative examples 1 to 4 were applied to the face after cleansing in the morning and evening every day for 4 weeks. Skin texture changes were then measured by a visual-CR (facial skin image analyzer) after 4 weeks, respectively, and the depth of wrinkles and the degree of reduction in the area of wrinkles were evaluated by this method, and the test results are shown in table 1.
Table 1 skin texture variation test results
| Project | Reduced wrinkle depth% | Reduced wrinkle area% |
| Example 4 | 36.1 | 35.8 |
| Example 5 | 33.7 | 32.3 |
| Example 6 | 34.8 | 33.5 |
| Comparative example 1 | 24.5 | 22.4 |
| Comparative example 2 | 25.2 | 23.1 |
| Comparative example 3 | 27.1 | 26.3 |
| Comparative example 4 | 30.1 | 29.3 |
As shown in Table 1, the anti-wrinkle repair cosmetics prepared in examples 4 to 6 were excellent in the effect of example 4, and were capable of reducing wrinkles, improving firmness, and increasing skin elasticity. The comparison example 1 without the addition of the Abelmoschus manihot extract and the comparison example 2 without the addition of the chlorella extract have the worst performance, and the centella extract is used for replacing the same amount of chlorella extract in the comparison example 3, so that the anti-wrinkle effect is obviously reduced, and the hydrolyzed elastin, the Abelmoschus manihot extract, the Mirabilis jalapa extract, the chlorella extract, the cytokine stock solution and the sodium hyaluronate have good synergistic effect; the reduced performance of the comparative example 4, in which wheat germ oil was used in place of alligator oil, demonstrates that the cosmetic formulations of the present application have an important impact on the product's performance.
2. Repair testing
Test object: 140 healthy volunteers were selected, between 25-40 years of age, randomly assigned to 7 groups.
The test method comprises the following steps: the anti-wrinkle repair cosmetics of examples 4 to 6 and the anti-wrinkle repair cosmetics of comparative examples 1 to 4 were applied to the face after cleansing in the morning and evening every day for 4 weeks. Measuring the TEWL value of the cheek part by adopting a epidermis water loss measuring instrument; the integrity of the skin barrier function is well reflected by the TEWL, and the moisture loss change condition of the skin before and after the product is used is evaluated through the moisture loss TEWL value of the subject before and after the product is used, so that the repairing effect of the product in the aspect of improving the skin barrier function is evaluated.
Wherein Δtewl=100% × (TEWL 1-TEWL 2)/TEWL 1; wherein TEWL1: values before the product is not used; TEWL2: the value after using the product; the reduced TEWL value indicates reduced epidermis water loss, suggesting that the barrier is repaired; the larger Δtewl indicates that the greater the magnitude of the reduction in skin moisture loss, the better the healing effect, and the test results are shown in table 2.
TABLE 2 TEWL test results
As shown in Table 2, the anti-wrinkle repair cosmetics prepared in examples 4 to 6 have good repair effect on skin; the repairing effect of the skin repairing agent is obviously reduced by reducing or replacing one of the necessary components in comparative examples 1-4, and the repairing agent is proved to have a synergistic effect by reasonably matching the components, so that the skin repairing agent can effectively repair skin injury, provide nutrition for skin and improve skin elasticity and brightness.
The above embodiments are only preferred embodiments of the present application, and the scope of the present application is not limited thereto, but any insubstantial changes and substitutions made by those skilled in the art on the basis of the present application are intended to be within the scope of the present application as claimed.
Claims (6)
1. The anti-wrinkle repair cosmetic is characterized by comprising the following components in parts by mass:
25-40 parts of an anti-wrinkle repair composition, 10-20 parts of alligator oil, 3-8 parts of jojoba seed oil, 2-5 parts of panthenol, 1-3 parts of PEG-20 methyl glucose sesquistearate, 1-3 parts of hydrogenated lecithin, 0.5-1 part of tocopheryl acetate, 0.05-0.2 part of triethanolamine, 3-5 parts of butanediol, 0.3-1.5 part of carbomer, 0.01-0.2 part of propyl hydroxybenzoate, 0.02-0.05 part of EDTA disodium, 0.01-0.03 part of essence, 4-10 parts of glycerol and 50-70 parts of water;
the anti-wrinkle repair composition comprises the following components in parts by mass:
10-20 parts of hydrolyzed elastin, 10-15 parts of Abelmoschus manihot extract, 1-8 parts of Mirabilis jalapa extract, 5-10 parts of Chlorella extract, 0.2-1 part of cytokine stock solution, 0.1-2 parts of sodium hyaluronate, 2-10 parts of propylene glycol and 25-50 parts of water;
the preparation method of the anti-wrinkle repair composition comprises the following steps:
1) Uniformly mixing water, propylene glycol and sodium hyaluronate, heating, preserving heat, and cooling to obtain a mixed solution;
2) Adding hydrolyzed elastin, abelmoschus manihot extract, mirabilis jalapa extract, chlorella extract and cytokine stock solution into the mixed solution, stirring, and homogenizing to obtain anti-wrinkle repairing composition;
the cytokine stock solution comprises oligopeptide active matters, wherein the oligopeptide active matters comprise oligopeptide-3 and oligopeptide-1, the molecular weight of the oligopeptide active matters is 15-20kD, and the activity is more than 200000U/mL.
2. The anti-wrinkle repair cosmetic according to claim 1, wherein the anti-wrinkle repair composition comprises the following components in parts by mass: 15-20 parts of hydrolyzed elastin, 7-12 parts of Abelmoschus manihot extract, 3-6 parts of Mirabilis jalapa extract, 2-5 parts of Mirabilis Luo Mushe/stem extract, 5-8 parts of chlorella extract, 0.4-0.8 part of cytokine stock solution, 0.1-1 part of sodium hyaluronate, 3-5 parts of propylene glycol and 25-35 parts of water.
3. The anti-wrinkle repair cosmetic according to claim 1, wherein the preparation method of the anti-wrinkle repair composition comprises the steps of:
in the step 1), the heating temperature is 60-80 ℃, the heat preservation time is 20-30min, and the cooling temperature is 30-45 ℃;
in the step 2), the stirring speed is 500-700r/min, and the stirring time is 5-15min.
4. A method for preparing the anti-wrinkle repair cosmetic according to claim 1, comprising the steps of:
s1, mixing crocodile oil, jojoba seed oil, PEG-20 methyl glucose sesquistearate, hydrogenated lecithin, tocopheryl acetate and propyl hydroxybenzoate according to a formula amount, stirring, heating to 80-90 ℃, and preserving heat to obtain an oil phase mixture for later use;
s2, mixing the water, glycerol, panthenol, butanediol, carbomer and EDTA disodium according to the formula amount, stirring, heating to 80-90 ℃, and preserving heat to obtain a water phase mixture for later use;
s3, uniformly stirring the water phase mixture, adding the oil phase mixture, stirring in vacuum, and homogenizing to obtain a homogenized emulsion A;
s4, adding triethanolamine after the temperature of the homogenized emulsion A is reduced to 55-65 ℃ and homogenizing to obtain homogenized emulsion B;
s5, after the temperature of the homogenized emulsion B is reduced to 40-45 ℃, adding the anti-wrinkle repair composition and essence according to the formula amount, uniformly stirring, and homogenizing to obtain the anti-wrinkle repair cosmetic.
5. The method for producing an anti-wrinkle repair cosmetic according to claim 4, wherein in the step S3, the vacuum stirring speed is 400-600r/min and the vacuum degree is-0.05 to-0.07 MPa.
6. The method for preparing an anti-wrinkle repair cosmetic according to claim 4, comprising the steps of: in the step S1, the heat preservation time is 10-20min, and the stirring speed is 900-1100r/min;
in the step S2, the heat preservation time is 15-25min, and the stirring speed is 900-1100r/min;
in step S3, the homogenizing speed is 2000-3000r/min
In the step S4, the homogenizing speed is 2000-3000r/min;
in the step S5, the stirring speed is 400-600r/min, and the homogenizing speed is 2000-3000r/min.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
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| CN115463062B (en) * | 2022-09-26 | 2024-03-26 | 山东福瑞达生物股份有限公司 | Anti-aging repair emulsion and preparation method and application thereof |
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