CN114748367A - Moisturizing repair essence and preparation method thereof - Google Patents

Moisturizing repair essence and preparation method thereof Download PDF

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Publication number
CN114748367A
CN114748367A CN202210539938.5A CN202210539938A CN114748367A CN 114748367 A CN114748367 A CN 114748367A CN 202210539938 A CN202210539938 A CN 202210539938A CN 114748367 A CN114748367 A CN 114748367A
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parts
skin
moisturizing
extract
raw materials
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赵莉
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/345Alcohols containing more than one hydroxy group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60Sugars; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/005Preparations for sensitive skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59Mixtures
    • A61K2800/592Mixtures of compounds complementing their respective functions
    • A61K2800/5922At least two compounds being classified in the same subclass of A61K8/18

Abstract

The application provides a moisturizing repair essence and a preparation method thereof, and relates to the technical field of skin care products. The moisturizing repair essence comprises the following raw materials in parts by weight: 90-98 parts of water, 0.05-0.3 part of mannitol, 0.1-4 parts of trehalose, 0.05-5 parts of serum albumin, 30.03-0.25 part of oligopeptide-1-3 parts of glycerol, 2-8 parts of propylene glycol, 1-3 parts of 1, 2-hexanediol, 0.05-5 parts of glycoprotein and 40.5-1.5 parts of decapeptide. Under the coordination effect of mannitol, trehalose, serum protein, glycoprotein, oligopeptide-3 and decapeptide-4, the skin care cream can effectively sooth the skin, stimulate cell regeneration, supplement collagen, and has prominent effects on allergy, redness, injury and skin barrier injury; in addition, the glycerin, the propylene glycol and the 1, 2-hexanediol act together, so that the moisturizing effect on the skin can be ensured, the protection can be provided, and the use comfort level is high.

Description

Moisturizing repair essence and preparation method thereof
Technical Field
The application relates to the technical field of skin care products, in particular to a moisturizing repair essence and a preparation method thereof.
Background
Environmental pollution and air deterioration are negative consequences of developing countries striving to make rapid economic developments. The first barrier of human body, namely the skin, is a serious examination, and under various stresses such as environmental change, air pollution, ultraviolet radiation, irregular daily work and rest, working and living pressure and the like, the skin state is increasingly worse, the problems are increasingly prominent, such as water loss, skin lipid film balance damage, barrier damage and melanin pigmentation, then collagen loss and elasticity loss appear in the dermis layer, the skin becomes increasingly dry, dull, sensitive, loose and reddish, dry lines and even fine lines exist, and in severe cases, diseases such as eczema, acne, dermatitis, psoriasis and ichthyosis can be caused, and the skin is urgently needed to be rescued in order to prolong the life of the skin and resist aging.
However, most of the currently used cosmetics have the problems of unclear effect and certain adverse reactions, and products with definite and safe effects and the effects of calming allergy, relieving, repairing and improving the sebum membrane are very needed.
Disclosure of Invention
The application aims to provide the moisturizing repair essence which has the advantages of calming allergy, relieving, repairing and improving a sebum membrane.
Another object of the present application is to provide a method for preparing the moisturizing and repairing essence, so as to obtain the moisturizing and repairing essence.
The technical problem to be solved by the application is achieved by adopting the following technical scheme.
On one hand, the embodiment of the application provides a moisturizing repair essence which comprises the following raw materials in parts by weight: 90-98 parts of water, 0.05-0.3 part of mannitol, 0.1-4 parts of trehalose, 0.05-5 parts of serum albumin, 30.03-0.25 part of oligopeptide, 1-3 parts of glycerol, 2-8 parts of propylene glycol, 1-3 parts of 1, 2-hexanediol, 0.05-5 parts of glycoprotein and 40.5-1.5 parts of decapeptide.
On the other hand, the embodiment of the application provides a preparation method of the moisturizing and repairing essence, which comprises the following steps:
adding water, trehalose and mannitol into a water phase pot, uniformly stirring, and heating to obtain a mixture 1;
Adding glycerol, propylene glycol and 1, 2-hexanediol into an emulsifying pot, uniformly stirring, and heating to obtain an emulsion;
pouring the mixture 1 into the emulsion, and homogenizing to obtain a mixture 2;
and cooling the mixture 2, adding the rest raw materials, and stirring to obtain the moisturizing repair essence.
Compared with the prior art, the embodiment of the application has at least the following advantages or beneficial effects:
in the application, mannitol can eliminate free radicals in vivo (eliminate peroxynitrite anions generated by combination of superoxide radicals and nitroso ions) so as to reduce pigmentation, further keep skin bright and white, play a role in resisting aging, inhibit allergy, maintain skin stability and play a role in repairing, has a certain moisturizing effect, and can moisten skin;
the trehalose has good protection on a human body, can protect the activity of serum protein and glycoprotein when added into a formula, thereby ensuring the action effect of the application, has good moisture retention, can clear free radicals generated by alpha and beta rays, and ensures that cell DNA is not easy to mutate, thereby playing a role in stabilizing skin and repairing skin;
the serum albumin contains more fatty acids, and can carry the fatty acids to the inside of the skin to form all biological membranes around and in cells, so that the regeneration of the cells can be promoted, the fibroblasts in the dermis layer are promoted to produce elastin, the skin is repaired, and the activity of the skin is kept;
Oligopeptide-3 has high efficiency of being absorbed by cells, stimulates the regeneration of the cells, is convenient for supplementing collagen after being directly absorbed by the cells, can repair skin, has the effect of highlighting and stimulating the cells under the combined action of the collagen and the glycoprotein, has mild action, is not easy to cause allergy, and can sooth the skin;
the glycoprotein has a structure similar to that of membrane protein, is easy to enter body fluid through the membrane protein with vector property, further treats skin disorder, contains amino polysaccharide substances, can stimulate the vasodilatation of catkin, improves microcirculation and has good repairing effect on damaged skin;
the decapeptide-4 is a synthetic peptide consisting of arginine, aspartic acid, cysteine, glutamic acid, leucine, methionine and tyrosine, and can condition the skin, promote the repair of damaged skin and maintain the stability of the skin;
the glycerol molecule contains three-OH groups which can form hydrogen bonds with water molecules, bind water, play a good role in moisture absorption and preservation, have an obvious moisturizing effect on human skin and can increase the solubility of other components;
the propylene glycol is moisturizing, mild and refreshing, has low sticky feeling, and can effectively provide a comfortable moisturizing effect;
The 1, 2-hexanediol has the effects of sterilization and moisture retention, is mild and not easy to become sensitive, and can play a role in moisture retention while maintaining the constant properties of essence for a long time;
under the coordination of mannitol, trehalose, serum protein, glycoprotein, oligopeptide-3 and decapeptide-4, the skin care cream can effectively soothe skin, stimulate cell regeneration, supplement collagen and has prominent effects on allergy, redness, injury and skin barrier injury; in addition, the glycerin, the propylene glycol and the 1, 2-hexanediol act together, so that the moisturizing effect on the skin can be guaranteed, comfortable protection can be provided, and the use comfort level is high.
The preparation method is simple and convenient, and can be used for batch production.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present application clearer, the technical solutions in the embodiments of the present application will be clearly and completely described below. The examples, in which specific conditions are not specified, were carried out according to conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are conventional products which are not indicated by manufacturers and are commercially available.
It should be noted that, in the present application, the embodiments and features of the embodiments may be combined with each other without conflict. The present application will be described in detail below with reference to specific examples.
The application provides a moisturizing repair essence which comprises the following raw materials in parts by weight: 90-98 parts of water, 0.05-0.3 part of mannitol, 0.1-4 parts of trehalose, 0.05-5 parts of serum albumin, 30.03-0.25 part of oligopeptide-1-3 parts of glycerol, 2-8 parts of propylene glycol, 1-3 parts of 1, 2-hexanediol, 0.05-5 parts of glycoprotein and 40.5-1.5 parts of decapeptide. In the application, mannitol can eliminate free radicals in vivo (eliminate peroxynitrite anions generated by combination of superoxide radicals and nitroso ions) so as to reduce pigmentation, further keep skin bright and white, play a role in resisting aging, inhibit allergy, maintain skin stability and play a role in repairing, has a certain moisturizing effect, and can moisten skin;
the trehalose has good protection on a human body, can protect the activity of serum protein and glycoprotein when added into a formula, thereby ensuring the action effect of the application, has good moisture retention, can clear free radicals generated by alpha and beta rays, and ensures that cell DNA is not easy to mutate, thereby playing a role in stabilizing skin and repairing skin;
the serum albumin contains more fatty acids, and can carry the fatty acids to the inside of the skin to form all biological membranes around and in cells, so that the regeneration of the cells can be promoted, the fibroblasts in the dermis layer are promoted to produce elastin, the skin is repaired, and the activity of the skin is kept;
Oligopeptide-3 has high efficiency of being absorbed by cells, stimulates the regeneration of the cells, is convenient for supplementing collagen after being directly absorbed by the cells, can repair skin, has the effect of highlighting and stimulating the cells under the combined action of the collagen and the glycoprotein, has mild action, is not easy to cause allergy, and can sooth the skin;
the glycoprotein has a structure similar to that of membrane protein, is easy to enter body fluid through the membrane protein with vector property, further treats skin disorder, contains amino polysaccharide substances, can stimulate the vasodilatation of catkin, improves microcirculation and has good repairing effect on damaged skin;
the decapeptide-4 is a synthetic peptide consisting of arginine, aspartic acid, cysteine, glutamic acid, leucine, methionine and tyrosine, and can condition the skin, promote the repair of damaged skin and maintain the stability of the skin;
the glycerol molecule contains three-OH groups which can form hydrogen bonds with water molecules, bind water, play a good role in moisture absorption and preservation, have an obvious moisturizing effect on human skin and can increase the solubility of other components;
the propylene glycol is moisturizing, mild and refreshing, has low sticky feeling, and can effectively provide a comfortable moisturizing effect;
The 1, 2-hexanediol has the effects of sterilization and moisture retention, is mild and not easy to become sensitive, and can play a role in moisture retention while maintaining the constant properties of essence for a long time;
under the coordination effect of mannitol, trehalose, serum protein, glycoprotein, oligopeptide-3 and decapeptide-4, the skin care cream can effectively sooth the skin, stimulate cell regeneration, supplement collagen, and has prominent effects on allergy, redness, injury and skin barrier injury; in addition, the glycerin, the propylene glycol and the 1, 2-hexanediol act together, so that the moisturizing effect on the skin can be guaranteed, comfortable protection can be provided, and the use comfort level is high.
In some embodiments of the present application, the essence further includes the following raw materials in parts by weight: 0.1-0.3 part of 3-o-ethyl ascorbic acid, 0.03-0.08 part of peony root extract, 0.01-0.05 part of ginseng root extract, 0.2-0.5 part of resveratrol, 0.1-0.3 part of ceramide, 0.01-0.03 part of Chinese violet extract, 0.1-0.3 part of bletilla striata root extract, 0.03-0.09 part of fermented red ginseng extract and 0.03-0.09 part of salvia miltiorrhiza extract.
The 3-o-ethyl ascorbic acid is a vitamin C derivative, can inhibit the generation of tyrosinase, thereby inhibiting the generation of melanin, has the effects of whitening and removing freckles, has good stability, is easy to penetrate through the stratum corneum of the skin to enter the dermis, is easy to be decomposed by biological enzyme to exert the biological effect of vitamin C, thereby improving the bioavailability and further playing a good role in whitening and resisting oxidation.
The radix paeoniae extract contains paeoniflorin, can inhibit bacteria and fungi, has a certain antibacterial property, can avoid infection when skin is inflamed, has a certain inhibiting effect on elastase, can remove free radicals and promote the activity of cathepsin, has a good antioxidant and anti-aging effect, has a good moisturizing effect, can play a role in whitening with other substances, has a good moisturizing effect, and can prevent fine wrinkles and peeling caused by dry skin.
The ginseng root extract can effectively delay skin aging, prevent the skin from drying and dehydrating, and increase the elasticity of the skin, thereby playing the roles of enabling the skin to be glossy and tender, and preventing and reducing skin wrinkles, wherein the contained active substances can inhibit the reduction performance of melanin, keep the skin smooth and white, and the contained ginsenoside can promote the phagocytic function of a reticuloendothelial system and increase the concentration of a mouse serum nonspecific antibody.
The resveratrol contains non-flavonoid polyphenol compounds with stilbene structures, has remarkable effects of resisting oxidation and free radicals and oxidation stress, has a good inhibition effect on tyrosinase in B16 cells, can reduce the generation amount of AGEs, inhibit protein carbonylation, reduce the content of Advanced Oxidation Protein Products (AOPP), has an anti-saccharification effect, and has anti-inflammatory, bactericidal and moisturizing effects.
Ceramide has a structure similar to that of substances forming the skin stratum corneum, can quickly permeate into the skin, promotes the skin to keep a balanced state, can be combined with water in the stratum corneum to form a net structure, locks water, has a good moisturizing effect, can strengthen the skin barrier, rebuilds cells, and forms an effective barrier to prevent water loss and reduce the influence of the external environment. It can be used together with other ingredients to stabilize skin state and prevent skin inflammation and allergy.
The herba violae extract has the effects of clearing away heat and toxic materials, cooling blood and relieving swelling, can have a good antibacterial effect on soul, can have a certain treatment effect on inflammatory reactions such as acne of the skin, can be combined with water in the stratum corneum to form a net structure, locks moisture, has a good moisturizing effect, and improves the moisture content of the skin.
The bletilla striata root extract is an antioxidant, a skin whitening agent and an anti-inflammatory agent with obvious effects.
The fermented red ginseng extract is rich in panaxatriol saponins, can inhibit keratinocyte apoptosis, promote photodamage repair, promote fibroblast synthesis, and also can increase collagen level, so that the effects of resisting wrinkles and aging are achieved, in addition, the fermented red ginseng extract can inhibit the activity of neuraminidase, has the whitening effect, contains ginseng polysaccharide, can form a protective film on the surface of skin, removes free radicals, and has a protective effect.
The Salvia miltiorrhiza Bunge extract has effects of promoting collagen proliferation, resisting aging and wrinkle, resisting oxidation, promoting hyaluronic acid production, and improving moisture retention.
Under the combined action of the ingredients, the essence can mildly and effectively play roles in repairing, resisting aging, resisting wrinkles, whitening and preserving moisture, has comprehensive functions and fresh texture, and has a good skin absorption effect.
In some embodiments of the present application, the glycoprotein is specifically fibronectin. Fibronectin has extremely high affinity to the cell surface, can be combined with collagen fibers to form a net, and encloses fibroblasts in the collagen net, so that the adhesion between cells and organs and the adhesion between cells and organs are promoted, the relationship between cells is regulated, the normal function of cells can be restored, the division of cells is promoted, severe skin disorder can be treated, and the functions of promoting skin regeneration, healing wounds, moistening the skin, stimulating hair growth and the like are realized. It has high matching degree with other components and good effect.
In some embodiments of the present application, the essence comprises the following raw materials in parts by weight: 93-95 parts of water, 0.1-0.2 part of mannitol, 2-3 parts of trehalose, 2-3.5 parts of serum albumin, 30.15-0.2 part of oligopeptide-2.5 parts of glycerol, 3-5 parts of propylene glycol, 1, 2-hexanediol 1.5-2.5 parts of glycoprotein and 40.8-1.2 parts of decapeptide. The proportion is the preferred proportion, and the effect is good.
In some embodiments of the present application, the essence comprises the following raw materials in parts by weight: 93-95 parts of water, 0.1-0.2 part of mannitol, 2-3 parts of trehalose, 2-3.5 parts of serum albumin, 30.15-0.2 part of oligopeptide, 2-2.5 parts of glycerol, 3-5 parts of propylene glycol, 1.5-2.5 parts of 1, 2-hexanediol, 2-3 parts of glycoprotein, 40.8-1.2 parts of decapeptide, 0.15-0.25 part of 3-o-ethyl ascorbic acid, 0.05-0.07 part of radix paeoniae alba extract, 0.02-0.04 part of ginseng root extract, 0.3-0.5 part of resveratrol, 0.15-0.25 part of ceramide, 0.02-0.03 part of herba violae extract, 0.15-0.25 part of rhizoma bletillae root extract, 0.05-0.07 part of fermented red ginseng extract and 0.05-0.07 part of Salvia miltiorrhiza extract. The proportion is the preferred proportion, and the effect is good.
The application also provides a preparation method of the moisturizing and repairing essence, which comprises the following steps:
adding water, trehalose and mannitol into a water phase pot, stirring uniformly, and heating to obtain a mixture 1;
adding glycerol, propylene glycol and 1, 2-hexanediol into an emulsifying pot, uniformly stirring, and heating to obtain an emulsion;
pouring the mixture 1 into the emulsion, and homogenizing to obtain a mixture 2;
and cooling the mixture 2, adding the rest raw materials, and stirring to obtain the moisturizing repair essence.
In some embodiments of the present application, the mixture 1 is heated at a temperature of 80 to 90 ℃.
In some embodiments of the present application, the emulsion is heated at a temperature of 75-85 ℃.
In some embodiments of the present application, the homogenization treatment of the mixing 2 is specifically a homogenization treatment at 75-85 ℃ for 15-30 min.
In some embodiments of the present application, the mixture 2 is cooled to 38-43 ℃ and then the remaining raw materials are added, specifically, the mixture is stirred at 3000rpm of 2000-20 min after the addition of the remaining raw materials.
The features and properties of the present application are described in further detail below with reference to examples.
Example 1
A preparation method of moisturizing and repairing essence comprises the following steps:
raw materials: 90g of water, 0.05g of mannitol, 0.1g of trehalose, 0.05g of serum albumin, 30.03g of oligopeptide, 1g of glycerol, 2g of propylene glycol, 1g of 1, 2-hexanediol, 0.05g of glycoprotein and 40.5g of decapeptide.
Adding water, trehalose and mannitol into a water phase pot, uniformly stirring, and heating to 80 ℃ to obtain a mixture 1;
adding glycerol, propylene glycol and 1, 2-hexanediol into an emulsifying pot, uniformly stirring, and heating to 75 ℃ to obtain an emulsion;
pouring the mixture 1 into the emulsion, and homogenizing at 75 deg.C for 15min to obtain mixture 2;
And cooling the mixture 2 to 36-43 ℃, adding the rest raw materials, and stirring at 2000rpm for 10min to obtain the moisturizing repair essence.
Example 2
A preparation method of the moisturizing and repairing essence comprises the following steps:
raw materials: 93g of water, 0.1g of mannitol, 2g of trehalose, 2g of serum albumin, 30.15g of oligopeptide, 2-2.5g of glycerol, 3g of propylene glycol, 1.5g of 1, 2-hexanediol, 2g of glycoprotein and 40.8g of decapeptide.
Adding water, trehalose and mannitol into a water phase pot, uniformly stirring, and heating to 83 ℃ to obtain a mixture 1;
adding glycerol, propylene glycol and 1, 2-hexanediol into an emulsifying pot, uniformly stirring, and heating to 78 ℃ to obtain an emulsion;
pouring the mixture 1 into the emulsion, and homogenizing at 78 deg.C for 18min to obtain mixture 2;
and cooling the mixture 2 to 38 ℃, adding the rest raw materials, and stirring at the rotating speed of 2300rpm for 13min to obtain the moisturizing repair essence.
Example 3
A preparation method of moisturizing and repairing essence comprises the following steps:
raw materials: 94g of water, 0.15g of mannitol, 2.5g of trehalose, 3g of serum albumin, 30.18g of oligopeptide, 2.3g of glycerol, 4g of propylene glycol, 2g of 1, 2-hexanediol, 2.5g of glycoprotein and 41g of decapeptide-41.
Adding water, trehalose and mannitol into a water phase pot, uniformly stirring, and heating to 80-90 ℃ to obtain a mixture 1;
Adding glycerol, propylene glycol and 1, 2-hexanediol into an emulsifying pot, uniformly stirring, and heating to 80 ℃ to obtain an emulsion;
pouring the mixture 1 into the emulsion, and homogenizing at 80 deg.C for 23min to obtain mixture 2;
and cooling the mixture 2 to 40 ℃, adding the rest raw materials, and stirring at the rotating speed of 2500rpm for 15min to obtain the moisturizing repair essence.
Example 4
A preparation method of moisturizing and repairing essence comprises the following steps:
raw materials: 95g of water, 0.2g of mannitol, 3g of trehalose, 3.5g of serum albumin, 30.2g of oligopeptide-2 g, 2.5g of glycerol, 5g of propylene glycol, 2.5g of 1, 2-hexanediol, 3g of glycoprotein and 41.2g of decapeptide-41.2 g.
Adding water, trehalose and mannitol into a water phase pot, uniformly stirring, and heating to 88 ℃ to obtain a mixture 1;
adding glycerol, propylene glycol and 1, 2-hexanediol into an emulsifying pot, uniformly stirring, and heating to 83 ℃ to obtain an emulsion;
pouring the mixture 1 into the emulsion, and homogenizing at 83 deg.C for 25min to obtain mixture 2;
and cooling the mixture 2 to 41 ℃, adding the rest raw materials, and stirring at the rotating speed of 2800rpm for 18min to obtain the moisturizing repair essence.
Example 5
A preparation method of moisturizing and repairing essence comprises the following steps:
Raw materials: 98g of water, 0.3g of mannitol, 4g of trehalose, 5g of serum albumin, 30.25g of oligopeptide, 3g of glycerol, 8g of propylene glycol, 3g of 1, 2-hexanediol, 5g of glycoprotein and 41.5g of decapeptide.
Adding water, trehalose and mannitol into a water phase pot, stirring uniformly, and heating to 90 ℃ to obtain a mixture 1;
adding glycerol, propylene glycol and 1, 2-hexanediol into an emulsifying pot, uniformly stirring, and heating to 85 ℃ to obtain an emulsion;
pouring the mixture 1 into the emulsion, and homogenizing at 85 deg.C for 30min to obtain mixture 2;
and cooling the mixture 2 to 43 ℃, adding the rest raw materials, and stirring at the rotating speed of 3000rpm for 20min to obtain the moisturizing repair essence.
Example 6
This example is essentially the same as example 1, except that: also comprises 0.1g of 3-o-ethyl ascorbic acid, 0.03g of peony root extract, 0.01g of ginseng root extract, 0.2g of resveratrol, 0.1g of ceramide, 0.01g of Chinese violet extract, 0.1g of bletilla striata root extract, 0.03g of fermented red ginseng extract and 0.03g of salvia miltiorrhiza extract.
Example 7
This example is substantially the same as example 2, except that: also comprises 0.15g of 3-o-ethyl ascorbic acid, 0.05g of peony root extract, 0.02g of ginseng root extract, 0.3g of resveratrol, 0.15g of ceramide, 0.02g of Chinese violet extract, 0.15g of bletilla striata root extract, 0.05g of fermented red ginseng extract and 0.05g of salvia miltiorrhiza extract.
Example 8
This example is substantially the same as example 3, except that: also comprises 0.2g of 3-o-ethyl ascorbic acid, 0.06g of peony root extract, 0.03g of ginseng root extract, 0.4g of resveratrol, 0.2g of ceramide, 0.025g of Chinese violet extract, 0.2g of bletilla striata root extract, 0.06g of fermented red ginseng extract and 0.06g of salvia miltiorrhiza extract.
Example 9
This example is substantially the same as example 4, except that: also comprises 0.25g of 3-o-ethyl ascorbic acid, 0.07g of peony root extract, 0.04g of ginseng root extract, 0.5g of resveratrol, 0.25g of ceramide, 0.03g of Chinese violet extract, 0.25g of bletilla striata root extract, 0.07g of fermented red ginseng extract and 0.07g of salvia miltiorrhiza extract.
Example 10
This example is substantially the same as example 5, except that: also comprises 0.3g of 3-o-ethyl ascorbic acid, 0.08g of peony root extract, 0.05g of ginseng root extract, 0.5g of resveratrol, 0.3g of ceramide, 0.03g of Chinese violet extract, 0.3g of bletilla striata root extract, 0.09g of fermented red ginseng extract and 0.09g of salvia miltiorrhiza extract.
Comparative example
This comparative example is essentially the same as the examples, except that: no glycoprotein was added.
Examples of the experiments
(I) test on skin patches on human body
According to the cosmetic hygiene code 2015, 300 volunteers aged 18-60 years and meeting the experimental requirements are selected as test subjects to carry out skin patch experiments.
The essences of examples 1 to 10 were selected, and 30 persons were tested at random for each of the essences of examples, and the area of the forearm was 3X 3cm on the flexed side as the test site2The essence is uniformly applied to the tested part for 7 days at a rate of 0.05 +/-0.005 ml/time and 2 times per day, skin reactions are observed continuously, the skin reactions are scored according to the table 1, whether the test is continued or not is determined according to specific conditions when 3 or more skin reactions occur in the process, and after the test, the test result is recorded in the table 2.
TABLE 1
Figure BDA0003649888840000141
Figure BDA0003649888840000151
TABLE 2
Figure BDA0003649888840000152
According to the results in table 2, it can be known that the essence prepared by the present application is safe and non-irritating to the skin.
(II) skin repair experiment
70 female volunteers between 18-35 years of age were selected, randomly divided into 7 groups, and tested with the essences of examples 1-5, example 8 and comparative example, respectively. In an indoor environment with a relative humidity of 50% at 20 deg.C, an area of 3 × 3cm is selected on the left side of cheek2The area in which the skin surface was damaged by covering with essence at 1 ml/time and lactic acid at a concentration of 10% for 5min for 7 days, the degree of sting of the subject was evaluated at 2.5min and 5min on the first and seventh days, and the itching before and after use was tested, and the average volunteer score of each group was obtained, and the results are shown in table 3.
Degree of stabbing pain:
no irritation at 0 point
1 minute is slight
2 in degree
3 points of gravity
TABLE 3
Figure BDA0003649888840000161
Figure BDA0003649888840000171
According to table 3, it can be seen that the application can effectively alleviate skin irritation, has a repairing effect, and can stabilize skin conditions, and comparing comparative example and example 3, it can be seen that the lack of glycoprotein can lead to poor repairing effect of essence.
In summary, in the application, the mannitol can eliminate free radicals in vivo (eliminate peroxynitrite anions generated by combining superoxide free radicals and nitroso ions), so that pigmentation is reduced, skin is kept bright and white, an anti-aging effect is achieved, allergy can be inhibited, skin stability is maintained, a repairing effect is achieved, and the mannitol has a certain moisturizing effect and can moisten skin; the trehalose has good protection on a human body, can protect the activity of serum protein and glycoprotein when added into a formula, thereby ensuring the action effect of the application, has good moisture retention, can clear free radicals generated by alpha and beta rays, and ensures that cell DNA is not easy to mutate, thereby playing the role of stabilizing skin and repairing skin; the serum albumin contains more fatty acids, and can carry the fatty acids to the inside of the skin to form all biological membranes around and in cells, so that the serum albumin can promote cell regeneration, promote fibroblasts in a dermis layer to produce elastin, repair the skin and keep the activity of the skin; the oligopeptide-3 has high efficiency of being absorbed by cells, stimulates the regeneration of the cells, is convenient for the cells to directly absorb, supplements collagen, can repair skin, has the effect of remarkably stimulating the cells under the combined action of serum albumin and glycoprotein, has mild action, is not easy to cause allergy, and can soothe the skin; the glycoprotein has a structure similar to that of membrane protein, is easy to enter body fluid through the membrane protein with vector property so as to treat skin disorder, contains amino polysaccharide substances, can stimulate the expansion of catkin blood vessels, improves microcirculation and has good repairing effect on damaged skin; decapeptide-4 is a synthetic peptide consisting of arginine, aspartic acid, cysteine, glutamic acid, leucine, methionine and tyrosine, and can condition the skin, promote the repair of damaged skin, and maintain the stability of the skin; the glycerin molecule contains three-OH which can form hydrogen bonds with water molecules to bind water, so that the glycerin molecule has good moisture absorption and moisture retention effects, has obvious moisture retention effect on human skin and can increase the solubility of other components; the propylene glycol is moisture-retaining, mild and fresh, has low sticky feeling and can effectively provide a comfortable moisture-retaining effect; the 1, 2-hexanediol has the effects of sterilization and moisture retention, is mild and not easy to be sensitive, and can play a role in moisture retention while maintaining the long-time property of essence; under the coordination of mannitol, trehalose, serum protein, glycoprotein, oligopeptide-3 and decapeptide-4, the skin care cream can effectively soothe skin, stimulate cell regeneration, supplement collagen and has prominent effects on allergy, redness, injury and skin barrier injury; in addition, the glycerin, the propylene glycol and the 1, 2-hexanediol are acted together, so that the moisturizing effect on skin can be ensured, more comfortable protection can be provided, and the use comfort level is high.
The embodiments described above are some, but not all embodiments of the present application. The detailed description of the embodiments of the present application is not intended to limit the scope of the claimed application, but is merely representative of selected embodiments of the application. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.

Claims (10)

1. The moisturizing repair essence is characterized by comprising the following raw materials in parts by weight: 90-98 parts of water, 0.05-0.3 part of mannitol, 0.1-4 parts of trehalose, 0.05-5 parts of serum albumin, 30.03-0.25 part of oligopeptide, 1-3 parts of glycerol, 2-8 parts of propylene glycol, 1-3 parts of 1, 2-hexanediol, 0.05-5 parts of glycoprotein and 40.5-1.5 parts of decapeptide.
2. The moisturizing repair essence according to claim 1, further comprising the following raw materials in parts by weight: 0.1-0.3 part of 3-o-ethyl ascorbic acid, 0.03-0.08 part of peony root extract, 0.01-0.05 part of ginseng root extract, 0.2-0.5 part of resveratrol, 0.1-0.3 part of ceramide, 0.01-0.03 part of Chinese violet extract, 0.1-0.3 part of bletilla striata root extract, 0.03-0.09 part of fermented red ginseng extract and 0.03-0.09 part of salvia miltiorrhiza extract.
3. The moisturizing repair serum of claim 1, wherein the glycoprotein is specifically fibronectin.
4. The moisturizing and repairing essence according to claim 1, which is characterized by comprising the following raw materials in parts by weight: 93-95 parts of water, 0.1-0.2 part of mannitol, 2-3 parts of trehalose, 2-3.5 parts of serum albumin, 30.15-0.2 part of oligopeptide-2.5 parts of glycerol, 3-5 parts of propylene glycol, 1, 2-hexanediol, 1.5-2.5 parts of glycoprotein and 40.8-1.2 parts of decapeptide.
5. The moisturizing and repairing essence according to claim 2, which is characterized by comprising the following raw materials in parts by weight: 93-95 parts of water, 0.1-0.2 part of mannitol, 2-3 parts of trehalose, 2-3.5 parts of serum albumin, 30.15-0.2 part of oligopeptide, 2-2.5 parts of glycerol, 3-5 parts of propylene glycol, 1.5-2.5 parts of 1, 2-hexanediol, 2-3 parts of glycoprotein, 40.8-1.2 parts of decapeptide, 0.15-0.25 part of 3-o-ethyl ascorbic acid, 0.05-0.07 part of radix paeoniae alba extract, 0.02-0.04 part of ginseng root extract, 0.3-0.5 part of resveratrol, 0.15-0.25 part of ceramide, 0.02-0.03 part of herba violae extract, 0.15-0.25 part of rhizoma bletillae root extract, 0.05-0.07 part of fermented red ginseng extract and 0.05-0.07 part of Salvia miltiorrhiza extract.
6. The preparation method of the moisturizing repair essence according to any one of claims 1 to 5, comprising the following steps:
adding water, trehalose and mannitol into a water phase pot, uniformly stirring, and heating to obtain a mixture 1;
adding glycerol, propylene glycol and 1, 2-hexanediol into an emulsifying pot, uniformly stirring, and heating to obtain an emulsion;
pouring the mixture 1 into the emulsion, and homogenizing to obtain a mixture 2;
and cooling the mixture 2, adding the rest raw materials, and stirring to obtain the moisturizing repair essence.
7. The method for preparing moisturizing repair essence according to claim 6, wherein the heating temperature of the mixture 1 is 80-90 ℃.
8. The method for preparing moisturizing and repairing essence according to claim 6, wherein the heating temperature of the emulsion is 75-85 ℃.
9. The preparation method of the moisturizing and repairing essence as claimed in claim 6, wherein the homogenization treatment of the mixing 2 is specifically homogenization treatment at 75-85 ℃ for 15-30 min.
10. The preparation method of the moisturizing repair essence as claimed in claim 6, wherein the mixture 2 is cooled to 38-43 ℃ and then the remaining raw materials are added, specifically stirred at 3000rpm of 2000-20 min after the remaining raw materials are added.
CN202210539938.5A 2022-05-18 2022-05-18 Moisturizing repair essence and preparation method thereof Withdrawn CN114748367A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115252531A (en) * 2022-08-11 2022-11-01 睿博斯(北京)生物科技有限公司 Anti-wrinkle essence and preparation method thereof
CN115737501A (en) * 2022-11-16 2023-03-07 珂蓝(重庆)生物医药科技有限责任公司 Composition for rapidly repairing basement membrane band and reconstructing collagen and application

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115252531A (en) * 2022-08-11 2022-11-01 睿博斯(北京)生物科技有限公司 Anti-wrinkle essence and preparation method thereof
CN115737501A (en) * 2022-11-16 2023-03-07 珂蓝(重庆)生物医药科技有限责任公司 Composition for rapidly repairing basement membrane band and reconstructing collagen and application

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