CN111067838A - Whitening and freckle-removing composition, whitening and freckle-removing cream and preparation method thereof - Google Patents
Whitening and freckle-removing composition, whitening and freckle-removing cream and preparation method thereof Download PDFInfo
- Publication number
- CN111067838A CN111067838A CN202010043129.6A CN202010043129A CN111067838A CN 111067838 A CN111067838 A CN 111067838A CN 202010043129 A CN202010043129 A CN 202010043129A CN 111067838 A CN111067838 A CN 111067838A
- Authority
- CN
- China
- Prior art keywords
- phase
- parts
- whitening
- freckle
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/31—Hydrocarbons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/342—Alcohols having more than seven atoms in an unbroken chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/732—Starch; Amylose; Amylopectin; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
- A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
Abstract
The invention relates to a whitening and freckle-removing composition, a whitening and freckle-removing cream and a preparation method thereof, wherein the raw material components of the whitening and freckle-removing composition comprise 3-o-ethyl ascorbic acid, α -arbutin, corn starch, hydrolyzed corn starch octenyl succinate, shea butter fruit resin extract, cocamidopropyl dimethylamine, phenethyl resorcinol, thiolactic acid, palmitoyl tripeptide-5, hydrated silica and hydroxyethyl piperazine ethane sulfonic acid.
Description
Technical Field
The invention belongs to the technical field of daily chemicals, and particularly relates to a whitening and freckle-removing composition, a whitening and freckle-removing cream and a preparation method thereof.
Background
Skin color is mainly determined by the content of melanin in the skin, and the biosynthesis of melanin in melanocytes is a series of oxidation reactions catalyzed by enzymes. The excessive deposition of melanin in the epidermis layer of skin can blacken skin color, and the excessive deposition of melanin can form freckle and chloasma.
Whitening and freckle-removing cosmetics become one of the mainstream varieties of skin care cosmetics. At present, satisfactory whitening and freckle removing effects are difficult to achieve by using any one whitening component alone, so that a whitening agent with a composite effect is produced at present, but the existing composite whitening agent is only the superposition of the effects of various raw materials and cannot generate a synergistic effect, so that a larger breakthrough is difficult to achieve in the aspect of the effect, and the research on the human use safety of cosmetics added with the composite whitening agent is not deep, and a lot of unknown hidden dangers still exist.
Disclosure of Invention
The invention aims to provide a whitening and freckle-removing composition, a whitening and freckle-removing cream containing the whitening and freckle-removing composition and a preparation method of the whitening and freckle-removing cream. The whitening and freckle-removing composition has a synergistic effect among various raw materials, can remarkably inhibit the reduction of skin brightness caused by ultraviolet rays when being added into cosmetics, can accelerate the decomposition and excretion of melanin, and reduces skin pigmentation, so that the whitening and freckle-removing composition has dual effects of whitening and removing freckles.
The technical scheme of the invention is as follows:
a whitening and speckle removing composition comprises 3-o-ethyl ascorbic acid, α -arbutin, corn starch, hydrolyzed corn starch octenyl succinate, shea butter fruit resin extract, cocamidopropyl dimethylamine, phenethyl resorcinol, thiolactic acid, palmitoyl tripeptide-5, hydrated silica, and hydroxyethyl piperazine ethane sulfonic acid.
3-o-ethyl ascorbic acid, also known as vitamin C ethyl ether, is a vitamin C derivative that readily enters the dermis layer through the stratum corneum, breaks down biological enzymes in the body and exerts the biological effects of vitamin C. The main effects comprise: after entering the dermis, the collagen directly participates in the synthesis of collagen to repair the activity of skin cells, so that the collagen is increased, the skin becomes full and elastic, and the skin is fine and smooth; 2. inhibiting tyrosinase activity, inhibiting the formation of melanin, reducing the melanin to be colorless, and efficiently whitening skin; 3. the antioxidant effect is excellent in cosmetics, and the utilization rate of VC is ensured; 4. the gel has oleophilic and hydrophilic structures, is easy to be absorbed by skin and can directly reach the dermis; 5. strong antibacterial and anti-inflammatory effects, and can resist inflammation caused by sunlight; 6. good stability, light resistance, heat resistance, acid resistance, alkali resistance, salt resistance and air oxidation; 7. the effect of vitamin C and its derivatives in inhibiting tyrosinase.
α -arbutin has good therapeutic effect on scar caused by ultraviolet burn, and has good antiinflammatory, repairing and whitening effects, and can inhibit melanin generation and deposition, and remove mottle and freckle α -arbutin has whitening mechanism of directly inhibiting tyrosinase activity, thereby reducing melanin generation.
The Butyrospermum parkii fruit resin extract contains elements such as vitamin A, vitamin E, vitamin B6, protein and the like, can supplement oil lacking in epidermal cells of a human body, and has the effect of delaying skin aging. Can also prevent the water loss of the skin, provide sufficient water for the skin, help wound healing and increase the defense capability of the skin.
Palmitoyl tripeptide-5, promotes skin cell growth, inhibits oxygen radicals and hydroxyl radicals, promotes the synthesis of matrix proteins, particularly collagen, and may also increase the production of elastin, hyaluronic acid, glycosaminoglycans, and fibronectin. In addition, the skin elasticity can be increased by increasing the activity of stromal cells to promote the synthesis of collagen.
The hydrated silica has certain function of reflecting ultraviolet rays, so that the hydrated silica can play a role of protecting ultraviolet rays from the aspect of ultraviolet shielding.
The hydroxyethyl piperazine ethane sulfonic acid has a certain effect of softening cutin, can promote old cutin cells of the epidermis layer of the skin to peel off, smooth and soften the skin and brighten the skin color.
Furthermore, the raw material components of the whitening and freckle-removing composition comprise, by weight, 2-5 parts of 3-o-ethyl ascorbic acid, 1-3 parts of α -arbutin, 0.5-1 part of corn starch, 0.2-0.5 part of hydrolyzed corn starch octenyl succinate, 0.1-0.3 part of shea butter extract, 0.1-0.2 part of cocamidopropyl dimethylamine, 0.06-0.2 part of phenethyl resorcinol, 0.04-0.1 part of thiolactic acid, 0.01-0.03 part of palmitoyl tripeptide-50.01-silica, 0.01-0.03 part of hydrate and 0.5-1.5 part of hydroxyethyl piperazine ethane sulfonic acid.
Further, the raw material components of the whitening and freckle-removing composition comprise, by weight, 3-o-ethyl ascorbic acid, α -arbutin 2, corn starch 0.73, hydrolyzed corn starch 0.34, hydrolyzed corn starch octenyl succinate 0.34, shea butter fruit resin extract 0.24, cocamidopropyl dimethylamine 0.13, phenethyl resorcinol 0.11, thiolactic acid 0.07, palmitoyl tripeptide-50.02, hydrated silica 0.02 and hydroxyethyl piperazine ethane sulfonic acid 1.
The whitening and freckle-removing cream comprises a phase A, a phase B, a phase C and a phase D, wherein the phase A consists of water, glycerol, propylene glycol, xanthan gum and carbomer, the phase B consists of squalane, caprylic/capric triglyceride, polydimethylsiloxane, cetearyl alcohol/cetearyl glucoside, glyceryl stearate/PEG-100 stearate, cetearyl alcohol, bisabolol and tocopherol, the phase C is arginine, and the phase D consists of a whitening and freckle-removing composition, fullerene, carnosine, a plant extract and a penetration enhancer.
Further, the raw material components of the phase A comprise the following components in parts by weight: 50-70 parts of water, 3-5 parts of glycerol, 3-5 parts of propylene glycol, 0.05-0.15 part of xanthan gum and 0.1-0.3 part of carbomer; the raw material components of the phase B comprise: 3-8 parts of squalane, 3-6 parts of caprylic/capric triglyceride, 2-5 parts of polydimethylsiloxane, 2-3 parts of cetearyl alcohol/cetearyl glucoside, 1-2 parts of glyceryl stearate/PEG-100 stearate, 2-3 parts of cetearyl alcohol, 0.6-1.2 parts of bisabolol and 0.6-1.2 parts of tocopherol; the phase C is 0.01 to 0.03 weight part of arginine; the raw material components of the phase D comprise: 6-10 parts of whitening and freckle-removing composition, 0.1-0.3 part of fullerene, 0.1-0.3 part of carnosine, 1-3 parts of plant extract and 1-1.5 parts of penetration enhancer.
Further, the raw material components of the plant extract comprise a gentian root extract, propylene glycol and water, and the raw material components of the penetration enhancer comprise laurocapram, water, 1, 2-hexanediol, gold and tremella polysaccharide.
Further, phase B also comprises a first preservative, phase C also comprises a second preservative, a fragrance and a coloring agent, wherein the first preservative is methyl hydroxybenzoate and propyl hydroxybenzoate, and the second preservative is phenoxyethanol/ethylhexyl glycerol.
The preparation method of the whitening and freckle-removing cream comprises the following steps:
(1) respectively weighing the raw materials of phase A, mixing the raw materials, stirring and heating to 80-85 ℃ to obtain a water phase;
(2) respectively weighing each raw material of the phase B, mixing the raw materials, stirring and heating to 80-85 ℃ to obtain an oil phase;
(3) adding oil phase into water phase, stirring, adding phase C, homogenizing for emulsifying, and keeping temperature for 15-25min to obtain emulsion;
(4) and cooling the emulsion to below 46 ℃, adding the phase D, and uniformly stirring to obtain the whitening and freckle-removing cream.
Further, in the step (3), the homogenizing speed is 3000-3500r/min, and the homogenizing time is 3-5 min.
The whitening and freckle-removing composition is applied to whitening and freckle-removing cosmetics.
The invention has the beneficial effects that:
the whitening and freckle-removing composition is prepared by adopting 3-o-ethyl ascorbic acid, α -arbutin, corn starch, hydrolyzed corn starch octenyl succinate, shea butter fruit resin extract, cocamidopropyl dimethylamine, phenethyl resorcinol, thiolactic acid, palmitoyl tripeptide-5, hydrated silica and hydroxyethyl piperazine ethane sulfonic acid as raw materials and carrying out proper weight proportion.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention will be described in detail below. It is to be understood that the described embodiments are merely a few embodiments of the invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the examples given herein without any inventive step, are within the scope of the present invention. In the following examples, 1 part by weight represents 1 g.
Example 1
The embodiment provides a whitening and freckle-removing cream which comprises the following raw material components:
phase A: 58.3 parts of water, 4 parts of glycerol, 4 parts of propylene glycol, 0.1 part of xanthan gum and 0.2 part of carbomer;
phase B: 5 parts by weight of squalane, 4 parts by weight of caprylic/capric triglyceride, 3 parts by weight of polydimethylsiloxane, 2.5 parts by weight of cetearyl alcohol/cetearyl glucoside, 1.5 parts by weight of glyceryl stearate/PEG-100 stearate, 2.5 parts by weight of cetearyl alcohol, 1 part by weight of bisabolol, 1 part by weight of tocopherol, 0.15 part by weight of methylparaben, and 0.1 part by weight of propylparaben;
and C phase: 0.02 part by weight of arginine;
phase D: 8 parts of whitening and freckle-removing composition, 0.2 part of fullerene, 0.2 part of carnosine, 1 part of laurocapram, 0.2 part of penetration enhancer composition, 2 parts of plant extract, 1 part of phenoxyethanol/ethylhexyl glycerin, 0.05 part of essence, 754700.00017 parts of CI, 191400.00060 parts of CI;
the preparation method of the whitening and freckle-removing composition comprises the following steps of weighing 3 weight parts of 3-o-ethyl ascorbic acid, 2 weight parts of α -arbutin, 0.73 weight part of corn starch, 0.34 weight part of hydrolyzed corn starch octenyl succinate, 0.24 weight part of shea butter fruit resin extract, 0.13 weight part of cocamidopropyl dimethylamine, 0.11 weight part of phenethyl resorcinol, 0.07 weight part of thiolactic acid, 50.02 weight parts of palmitoyl tripeptide, 0.02 weight part of hydrated silica and 1 weight part of hydroxyethyl piperazine ethane sulfonic acid, and uniformly mixing the raw materials to obtain the whitening and freckle-removing composition;
the penetration enhancer composition is purchased from Guangzhou collona biotechnology limited, and comprises the raw material components of water, 1, 2-hexanediol, gold and tremella polysaccharide (96.5:1.5:1: 5); the plant extract is obtained from Guangdong Dimei Biotechnology GmbH, and comprises radix Gentianae extract, propylene glycol and water (5:50: 45).
Further, a method for preparing the whitening and freckle-removing cream is provided, which comprises the following steps:
(1) respectively weighing the raw materials of the phase A, mixing the raw materials, stirring and heating to 80 ℃ to obtain a water phase;
(2) respectively weighing each raw material of the phase B, mixing the raw materials, stirring and heating to 80 ℃ to obtain an oil phase;
(3) adding oil phase into water phase, stirring, adding phase C, homogenizing at 3000r/min for 5min, and keeping temperature for 15min to obtain emulsion;
(4) and cooling the emulsion to 46 ℃, adding the phase D, and uniformly stirring to obtain the whitening and freckle-removing cream.
Example 2
The embodiment provides a whitening and freckle-removing cream which comprises the following raw material components:
phase A: 58.3 parts of water, 4 parts of glycerol, 4 parts of propylene glycol, 0.1 part of xanthan gum and 0.2 part of carbomer;
phase B: 5 parts by weight of squalane, 4 parts by weight of caprylic/capric triglyceride, 3 parts by weight of polydimethylsiloxane, 2.5 parts by weight of cetearyl alcohol/cetearyl glucoside, 1.5 parts by weight of glyceryl stearate/PEG-100 stearate, 2.5 parts by weight of cetearyl alcohol, 1 part by weight of bisabolol, 1 part by weight of tocopherol, 0.15 part by weight of methylparaben, and 0.1 part by weight of propylparaben;
and C phase: 0.02 part by weight of arginine;
phase D: 8 parts of whitening and freckle-removing composition, 0.2 part of fullerene, 0.2 part of carnosine, 1 part of laurocapram, 0.2 part of penetration enhancer composition, 2 parts of plant extract, 1 part of phenoxyethanol/ethylhexyl glycerin, 0.05 part of essence, 754700.00017 parts of CI, 191400.00060 parts of CI;
the preparation method of the whitening and freckle-removing composition comprises the following steps of weighing 1 part by weight of 3-o-ethyl ascorbic acid, 4.8 parts by weight of α -arbutin, 0.73 part by weight of corn starch, 0.34 part by weight of hydrolyzed corn starch octenyl succinate, 0.24 part by weight of shea butter fruit resin extract, 0.13 part by weight of cocamidopropyl dimethylamine, 0.11 part by weight of phenethyl resorcinol, 0.07 part by weight of thiolactic acid, 50.02 parts by weight of palmitoyl tripeptide, 0.02 part by weight of hydrated silica and 0.2 part by weight of hydroxyethyl piperazine ethane sulfonic acid, and uniformly mixing the raw materials to obtain the whitening and freckle-removing composition;
the penetration enhancer composition is purchased from Guangzhou collona biotechnology limited, and comprises the raw material components of water, 1, 2-hexanediol, gold and tremella polysaccharide (96.5:1.5:1: 5); the plant extract is obtained from Guangdong Dimei Biotechnology GmbH, and comprises radix Gentianae extract, propylene glycol and water (5:50: 45).
Further, a method for preparing the whitening and freckle-removing cream is provided, which comprises the following steps:
(1) respectively weighing the raw materials of the phase A, mixing the raw materials, stirring and heating to 80 ℃ to obtain a water phase;
(2) respectively weighing each raw material of the phase B, mixing the raw materials, stirring and heating to 80 ℃ to obtain an oil phase;
(3) adding oil phase into water phase, stirring, adding phase C, homogenizing at 3000r/min for 5min, and keeping temperature for 15min to obtain emulsion;
(4) and cooling the emulsion to 46 ℃, adding the phase D, and uniformly stirring to obtain the whitening and freckle-removing cream.
Example 3
The embodiment provides a whitening and freckle-removing cream which comprises the following raw material components:
phase A: 50 parts of water, 3 parts of glycerol, 3 parts of propylene glycol, 0.05 part of xanthan gum and 0.1 part of carbomer;
phase B: 3 parts by weight of squalane, 3 parts by weight of caprylic/capric triglyceride, 2 parts by weight of polydimethylsiloxane, 2 parts by weight of cetearyl alcohol/cetearyl glucoside, 2 parts by weight of glyceryl stearate/PEG-100 stearate, 2 parts by weight of cetearyl alcohol, 0.6 part by weight of bisabolol, 0.6 part by weight of tocopherol, 0.15 part by weight of methylparaben, 0.1 part by weight of propylparaben;
and C phase: 0.01 part by weight of arginine;
phase D: 6 parts of whitening and freckle-removing composition, 0.1 part of fullerene, 0.1 part of carnosine, 0.8 part of laurocapram, 0.2 part of penetration enhancer composition, 1 part of plant extract, 0.06 part of phenoxyethanol/ethylhexyl glycerin, 0.05 part of essence, 754700.00017 parts of CI, and 191400.00060 parts of CI;
the preparation method of the whitening and freckle-removing composition comprises the following steps of weighing 2 parts by weight of 3-o-ethyl ascorbic acid, 1 part by weight of α -arbutin, 0.5 part by weight of corn starch, 0.2 part by weight of hydrolyzed corn starch octenyl succinate, 0.1 part by weight of shea butter extract, 0.1 part by weight of cocamidopropyl dimethylamine, 0.06 part by weight of phenethyl resorcinol, 0.04 part by weight of thiolactic acid, 50.01 parts by weight of palmitoyl tripeptide, 0.01 part by weight of hydrated silica and 0.5 part by weight of hydroxyethyl piperazine ethanesulfonic acid, and uniformly mixing the raw materials to obtain the whitening and freckle-removing composition;
the penetration enhancer composition is purchased from Guangzhou collona biotechnology limited, and comprises the raw material components of water, 1, 2-hexanediol, gold and tremella polysaccharide (96.5:1.5:1: 5); the plant extract is obtained from Guangdong Dimei Biotechnology GmbH, and comprises radix Gentianae extract, propylene glycol and water (5:50: 45).
Further, a method for preparing the whitening and freckle-removing cream is provided, which comprises the following steps:
(1) respectively weighing the raw materials of the phase A, mixing the raw materials, stirring and heating to 85 ℃ to obtain a water phase;
(2) respectively weighing each raw material of the phase B, mixing the raw materials, stirring and heating to 85 ℃ to obtain an oil phase;
(3) adding the oil phase into the water phase, stirring, adding phase C, homogenizing at 3500r/min for 3min, and maintaining the temperature for 25min to obtain emulsion;
(4) and cooling the emulsion to 46 ℃, adding the phase D, and uniformly stirring to obtain the whitening and freckle-removing cream.
Example 4
The embodiment provides a whitening and freckle-removing cream which comprises the following raw material components:
phase A: 70 parts of water, 5 parts of glycerol, 5 parts of propylene glycol, 0.15 part of xanthan gum and 0.3 part of carbomer;
phase B: 8 parts of squalane, 6 parts of caprylic/capric triglyceride, 5 parts of polydimethylsiloxane, 3 parts of cetearyl alcohol/cetearyl glucoside, 1 part of glyceryl stearate/PEG-100 stearate, 3 parts of cetearyl alcohol, 1.2 parts of bisabolol, 1.2 parts of tocopherol, 0.15 part of methylparaben and 0.1 part of propylparaben;
and C phase: 0.03 part by weight of arginine;
phase D: 10 parts of whitening and freckle-removing composition, 0.3 part of fullerene, 0.3 part of carnosine, 1 part of laurocapram, 0.5 part of penetration enhancer composition, 3 parts of plant extract, 0.06 part of phenoxyethanol/ethylhexyl glycerin, 0.05 part of essence, 754700.00017 parts of CI, and 191400.00060 parts of CI;
the preparation method of the whitening and freckle-removing composition comprises the following steps of weighing 5 parts by weight of 3-o-ethyl ascorbic acid, 3 parts by weight of α -arbutin, 1 part by weight of corn starch, 0.5 part by weight of hydrolyzed corn starch octenyl succinate, 0.3 part by weight of shea butter extract, 0.2 part by weight of cocamidopropyl dimethylamine, 0.2 part by weight of phenethyl resorcinol, 0.1 part by weight of thiolactic acid, 50.03 parts by weight of palmitoyl tripeptide, 0.03 part by weight of hydrated silica and 1.5 parts by weight of hydroxyethyl piperazine ethanesulfonic acid, and uniformly mixing the raw materials to obtain the whitening and freckle-removing composition;
the penetration enhancer composition is purchased from Guangzhou collona biotechnology limited, and comprises the raw material components of water, 1, 2-hexanediol, gold and tremella polysaccharide (96.5:1.5:1: 5); the plant extract is obtained from Guangdong Dimei Biotechnology GmbH, and comprises radix Gentianae extract, propylene glycol and water (5:50: 45).
Further, a method for preparing the whitening and freckle-removing cream is provided, which comprises the following steps:
(1) respectively weighing the raw materials of the phase A, mixing the raw materials, stirring and heating to 85 ℃ to obtain a water phase;
(2) respectively weighing each raw material of the phase B, mixing the raw materials, stirring and heating to 80 ℃ to obtain an oil phase;
(3) adding the oil phase into the water phase, stirring, adding phase C, homogenizing at 3500r/min for 5min, and maintaining the temperature for 20min to obtain emulsion;
(4) and cooling the emulsion to 46 ℃, adding the phase D, and uniformly stirring to obtain the whitening and freckle-removing cream.
Comparative example
The difference from example 1 is only that the whitening and spot-removing composition ingredients are not added.
First, sanitary safety inspection
TABLE 1 microbiological test results (example 1 sample)
TABLE 2 sanitary chemistry test results (sample of example 1)
II, toxicology test
1. Multiple skin irritation test
1.1 test substance: example 1 sample
1.2 animal and rearing environment: the healthy new zealand white rabbits without skin diseases are 4, common grade, provided by oriental cultivation ltd of the State of Metaplexis, and have an animal production license number: SCXK (su) 2017-; license number for experimental animals: SYXK (Su) No. 2017-0030; ambient temperature: 22 +/-2 ℃; relative humidity is 40-70%; feed source and identification number: jiangsu province cooperative medical bioengineering, llc, su gao (2014) 01008.
1.3 test methods: before the test, the hair on two sides of the spine of the rabbit is cut off, and the hair removing range is 3cm multiplied by 3cm respectively. During the test, about 0.5ml of the test substance is smeared on the unhaired skin on one side, the other side is used as a control, the smearing area is 2.5cm multiplied by 2.5cm, the smearing time is 1 time per day, and the smearing time is continuously 14 days. Shearing hair before each application from the next day, removing residual test substance with warm water, observing the result after 1h, scoring according to table 1 in cosmetic safety technical Specification, and treating the control area and the test area in the same way. At the end of the test, the skin irritation intensity was graded according to Table 2 in the technical Specification for cosmetic safety.
1.4 test results
No toxic effects other than irritation were observed, and the stimulation response points are shown in Table 3.
TABLE 3 results of multiple skin irritation tests of rabbits according to the present invention
2. Skin allergy test
2.1 test substance: example 1 sample
2.2 Positive substance: the positive control was 2, 4-dinitrochlorobenzene, and the solvent was acetone in sesame oil (acetone: 1 (v/v)). The positive control group is prepared by the laboratory from 10 and 15 days in 2018 to 11 and 14 days in 2018, the induction concentration is 2% (w/v), the excitation concentration is 1% (w/v), and the steps are the same as those of the experimental group.
2.3 animal and rearing environment: 30 healthy non-skin disease white guinea pigs with the weight of 244-300g, provided by Hengtai laboratory animal culture Co., Ltd, the animal production license number: SCXK (Su) 2015-0004, the animals were divided into two groups, 20 subjects and 10 subjects. License number for experimental animals: SYXK (Su) 2017-; ambient temperature: 22 +/-2 ℃; relative humidity is 40-70%; the main apparatus is as follows: an electronic scale (05-192); feed source and identification number: jiangsu province cooperative medical bioengineering, llc, su gao (2014) 01008.
2.4 test methods: local seal coating (BT) method.
And (3) induction contact: the guinea pigs were shaved 24h before the test to an area of about 6cm2 on the left of their back, and about 0.2ml of the test substance was applied to the skin of the area of 2cm x 2cm of hair removed on the left of the test subject animals in the experimental group, covered with two layers of gauze, one layer of cellophane, fixed with adhesive tape, and closed for 6 h. The same procedure was repeated on day 7 and day 14.
And (3) exciting contact: at 14d after the last induction, about 0.2ml of the test substance was applied to the skin of the right side of the animals of the test substance experimental group and the test substance control group, which had been unhaired by 2cm × 2cm before 24h, covered with two layers of gauze and one layer of cellophane, fixed with adhesive tape, and closed for 6 h. Skin reactions were observed 24 and 48 hours after challenge, and skin reaction scores and sensitization intensity were graded as specified in the technical Specification for cosmetic safety (2015 edition).
2.5 test results
The test substance has no skin reaction by adopting a local closed skin coating method, the skin reaction condition of animals in each group is observed at 24 and 48 hours and is shown in a table 4, and the influence of the test substance on the skin allergy test (BT method) result of guinea pigs and the weight of the animals is shown in a table 5.
TABLE 4 intensity of cutaneous allergic reactions in guinea pigs
*: the skin reaction scores are 0, 1,2, 3 and 4, respectively, and the ratio of the number of animals to the number of tested animals.
TABLE 5 guinea pig skin allergy test results (BT) method
3. Phototoxicity test on skin
3.1 test substance: example 1 sample
3.2 Positive substance: 8-methoxy psoralea fruit 10mg (produced by SIGMA company) is dissolved in 95% ethanol solution 40ml to obtain 0.025% 8-methoxy bone fat supplementing solution as positive substance.
3.3 animal and rearing environments: 6 healthy non-skin disease white guinea pigs with half of male and female, common grade, weight 266-: SCXK (su) 2015-: SYXK (Su) No. 2017-0030; ambient temperature: 22 +/-2 ℃; relative humidity is 40-70%; the main apparatus is as follows: an electronic scale (05-192); feed source and identification number: jiangsu province cooperative medical bioengineering, llc, su gao (2014) 01008.
3.4 irradiation equipment: an ultraviolet irradiator (Viber Lourmat, France, model: Bio-spectral system) with light intensity measuring and feedback program, software according to the irradiation light intensity and irradiation time curve, calculating the area integral under the curve, when the dose of the irradiated area of the animal reaches the set irradiation dose, automatically stopping irradiation.
3.5 test methods: test groups guinea pigs were shaved on both sides of the spine 24h prior to testing. 4 unhairing zones are prepared and numbered, the unhairing area of each block is about 2cm multiplied by 2cm, the left side is 1 and 3 zones, and the right side is 2 and 4 zones. The animals were fixed and 0.2ml of the test substance was evenly applied to zones 1 and 2, while no test substance was applied to zones 3 and 4. After 30min, areas 1 and 3 on the left side are covered with aluminum foil, the tape is fixed, areas 2 and 4 on the right side are irradiated by a UVA light source with the wavelength of 365nm, the irradiation dose is set to be 10j/cm2, skin reactions are observed for 1, 24,48 and 72h after irradiation, and skin reaction integrals of different observation periods of each animal are judged according to skin irritation reaction scoring standards in technical Specification for safety of cosmetics (2015 edition) skin phototoxicity test.
3.6 the results are shown in Table 6.
TABLE 6 phototoxicity test results of test substances on guinea pig skin
TABLE 7 phototoxicity test results of positive controls on guinea pig skin
The result of the light toxicity test on the guinea pig skin is as follows: no phototoxicity to the skin was observed. The number of animals with the skin reaction score sum of more than or equal to 2 in the irradiated area after the positive control substance is smeared is 6, and the test result of the positive control substance shows that the animals have positive reaction to the positive substance.
Three, human body skin patch test
1. The test substance: inventive example 1 sample
2. Negative control: blank control
3. Subject: the total number of 30 persons, 3 men and 27 women, the age of 22-60 years, meet the volunteer selection criteria of the subject.
4. The spot test method comprises the following steps: selecting a qualified spot tester, coating about 0.03g of a test object in the spot tester by a closed spot test method, externally applying a special adhesive tape to the back of the test object, removing the test object after 24h, observing skin reactions respectively at 0.5 h, 24h and 48h after removal, and recording the results according to the skin reaction grading standard in technical Specification for cosmetic safety (2015 edition).
5. The test results are shown in Table 8.
TABLE 8 test results of human skin patches
Fourth, efficacy test
1. Test of Effect of the present invention on skin Brightness of Guinea pig
1.1 test animals and groups: healthy male brown-yellow guinea pigs were taken and aged 10 weeks, weighed 240-.
1.2 test methods: selecting guinea pig with back of 5 × 5cm2For the test area, shaving, groups were each coated with each of examples 1-4, comparative examples and commercial whitening products in the test area, once daily in the morning and evening at a dose of 0.2 g/time for 28 consecutive days, and 2 times daily with a dose of 500mJ/cm per dose of UVB UV light on days 2, 5, 7, 8 and 9 after the application of the samples2Measuring the L value of the test area by using a color difference meter before irradiation and 28 days after sample application, and calculating the L value change value (△ L), which isValue (△ L) ═ LAfter irradiation－LBefore irradiation. The results are shown in Table 9.
1.3 test results
TABLE 9 Effect on guinea pig skin Brightness test results
| Sample (I) | △L |
| Model set | -23.19 |
| Example 1 | -4.55±0.35** |
| Example 2 | -9.06±0.57** |
| Example 3 | -5.71±0.41** |
| Example 4 | -5.28±0.28** |
| Comparative example | -22.13±1.22 |
| Commercially available product | -12.45±0.92* |
P <0.05, p <0.01 compared to model group.
As can be seen from the above table, △ L of the model group is reduced after the ultraviolet irradiation, which indicates that the skin brightness is reduced, and the samples applied in the examples of the present invention have a significant inhibition effect on the reduction of the skin brightness, which is significantly better than the commercially available whitening products, and the best is shown in example 1, and then the samples in examples 4, 3 and 2 (the difference from example 1 is only that the ratio of the whitening and spot removing composition is different).
2. Test of skin whitening Effect of human body according to the present invention
The subjects were selected 60, aged 25-40 years, and randomized into 6 groups of 10 individuals, each group being administered with each of the products of examples 1,2, 3, 4, comparative example, and commercial product, once a day, in the morning and evening, for 4 weeks. Skin color L a b value test was performed at 0 and 4 weeks to collect quantified values of skin color. Wherein, L value represents the balance from white to black, pure black is 0, pure white is 100, and the larger the value is, the closer to white is; a represents the balance from red to green, positive values represent red, negative values represent green, 0 is neutral; b values represent the yellow to blue balance, positive values represent yellow, negative values represent blue, and 0 is a neutral color. The test results are shown in Table 10.
TABLE 10 test results of skin whitening effect on human body
Compared to the initial value, # p < 0.05.
As can be seen from the above table, the subjects using examples 1,2, 3, and 4 of the present invention showed more significant increases in both L and a and more significant decreases in b after 4 weeks than the commercial products, indicating that the present invention has the effects of increasing skin whiteness, making the skin more ruddy and yellow-removed, and is significantly superior to the commercial products.
The above description is only for the specific embodiments of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art can easily conceive of the changes or substitutions within the technical scope of the present invention, and all the changes or substitutions should be covered within the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the appended claims.
Claims (10)
1. The whitening and freckle-removing composition is characterized by comprising the raw material components of 3-O-ethyl ascorbic acid, α -arbutin, corn starch, hydrolyzed corn starch octenyl succinate, shea butter fruit resin extract, cocamidopropyl dimethylamine, phenethyl resorcinol, thiolactic acid, palmitoyl tripeptide-5, hydrated silica and hydroxyethyl piperazine ethane sulfonic acid.
2. The composition for whitening and removing freckles as claimed in claim 1, wherein the raw material components of the composition for whitening and removing freckles comprise, by weight, 2-5 parts of 3-o-ethyl ascorbic acid, 1-3 parts of α -arbutin, 0.5-1 part of corn starch, 0.2-0.5 part of hydrolyzed corn starch octenyl succinate, 0.1-0.3 part of shea butter fruit resin extract, 0.1-0.2 part of cocamidopropyl dimethylamine, 0.06-0.2 part of phenethyl resorcinol, 0.04-0.1 part of thiolactic acid, 50.01-0.03 part of palmitoyl tripeptide, 0.01-0.03 part of hydrated silica and 0.5-1.5 part of hydroxyethyl piperazine ethane sulfonic acid.
3. The whitening and freckle-removing composition of claim 1, wherein the raw materials comprise, by weight, 3-o-ethyl ascorbic acid 3 parts, α -arbutin 2 parts, corn starch 0.73 part, hydrolyzed corn starch 0.34 part, hydrolyzed corn starch octenyl succinate 0.34 part, shea butter extract 0.24 part, cocamidopropyl dimethylamine 0.13 part, phenethyl resorcinol 0.11 part, thiolactic acid 0.07 part, palmitoyl tripeptide-50.02 part, hydrated silica 0.02 part, and hydroxyethyl piperazine ethanesulfonic acid 1 part.
4. A whitening and freckle-removing cream comprising the whitening and freckle-removing composition according to any one of claims 1 to 3, wherein the whitening and freckle-removing cream consists of a phase A, a phase B, a phase C and a phase D, the phase A consists of water, glycerol, propylene glycol, xanthan gum and carbomer, the phase B consists of squalane, caprylic/capric triglyceride, polydimethylsiloxane, cetearyl alcohol/cetearyl glucoside, glyceryl stearate/PEG-100 stearate, cetearyl alcohol, bisabolol and tocopherol, the phase C is arginine, and the phase D consists of the whitening and freckle-removing composition, fullerene, carnosine, a plant extract and a penetration enhancer.
5. The whitening and freckle-removing cream according to claim 4, wherein the phase A comprises the following raw material components in parts by weight: 50-70 parts of water, 3-5 parts of glycerol, 3-5 parts of propylene glycol, 0.05-0.15 part of xanthan gum and 0.1-0.3 part of carbomer; the raw material components of the phase B comprise: 3-8 parts of squalane, 3-6 parts of caprylic/capric triglyceride, 2-5 parts of polydimethylsiloxane, 2-3 parts of cetearyl alcohol/cetearyl glucoside, 1-2 parts of glyceryl stearate/PEG-100 stearate, 2-3 parts of cetearyl alcohol, 0.6-1.2 parts of bisabolol and 0.6-1.2 parts of tocopherol; the phase C is 0.01 to 0.03 weight part of arginine; the raw material components of the phase D comprise: 6-10 parts of whitening and freckle-removing composition, 0.1-0.3 part of fullerene, 0.1-0.3 part of carnosine, 1-3 parts of plant extract and 1-1.5 parts of penetration enhancer.
6. The cream of claim 4 or 5, wherein the raw material components of the plant extract comprise gentian root extract, propylene glycol and water, and the raw material components of the penetration enhancer comprise laurocapram, water, 1, 2-hexanediol, gold and tremella polysaccharide.
7. The cream of claim 4 or 5, wherein the phase B further comprises a first preservative, the phase C further comprises a second preservative, a fragrance and a colorant, the first preservative is methyl hydroxybenzoate and propyl hydroxybenzoate, and the second preservative is phenoxyethanol/ethylhexyl glycerol.
8. The preparation method of the whitening and freckle-removing cream according to any one of claims 4 to 7 is characterized by comprising the following steps of:
(1) respectively weighing the raw materials of phase A, mixing the raw materials, stirring and heating to 80-85 ℃ to obtain a water phase;
(2) respectively weighing each raw material of the phase B, mixing the raw materials, stirring and heating to 80-85 ℃ to obtain an oil phase;
(3) adding oil phase into water phase, stirring, adding phase C, homogenizing for emulsifying, and keeping temperature for 15-25min to obtain emulsion;
(4) and cooling the emulsion to below 46 ℃, adding the phase D, and uniformly stirring to obtain the whitening and freckle-removing cream.
9. The method for preparing a cream for whitening and removing speckle as claimed in claim 8, wherein in the step (3), the homogenizing speed is 3000-3500r/min, and the homogenizing time is 3-5 min.
10. Use of the whitening and freckle-removing composition of any one of claims 1 to 3 in whitening and freckle-removing cosmetics.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010043129.6A CN111067838A (en) | 2020-01-15 | 2020-01-15 | Whitening and freckle-removing composition, whitening and freckle-removing cream and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010043129.6A CN111067838A (en) | 2020-01-15 | 2020-01-15 | Whitening and freckle-removing composition, whitening and freckle-removing cream and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111067838A true CN111067838A (en) | 2020-04-28 |
Family
ID=70323391
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010043129.6A Pending CN111067838A (en) | 2020-01-15 | 2020-01-15 | Whitening and freckle-removing composition, whitening and freckle-removing cream and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111067838A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111544345A (en) * | 2020-06-05 | 2020-08-18 | 广州丽彦妆生物科技有限公司 | Production process of whitening and freckle-removing cream |
| CN111568847A (en) * | 2020-05-30 | 2020-08-25 | 杭州心悦化妆品有限公司 | Emulsion easy to be absorbed by skin and production process thereof |
| CN111920740A (en) * | 2020-08-27 | 2020-11-13 | 名宇(广东)化妆品科技有限公司 | 377 whitening cream and preparation method thereof |
| CN113520958A (en) * | 2021-09-08 | 2021-10-22 | 赤峰万泽药业股份有限公司 | Whitening and freckle-removing essence cream, preparation method and application |
| CN114504528A (en) * | 2020-12-25 | 2022-05-17 | 邱天英 | Targeted freckle-removing and whitening face cream |
| CN115025012A (en) * | 2022-05-09 | 2022-09-09 | 河北康正药业有限公司 | Whitening and freckle-removing cream and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107242982A (en) * | 2017-06-07 | 2017-10-13 | 广州科玛生物科技股份有限公司 | A kind of fair-skinned bright Virgin's milk liquid and preparation method thereof |
| CN110292535A (en) * | 2019-07-15 | 2019-10-01 | 广州露思生物科技有限公司 | A kind of whitening and spot eliminating cream |
-
2020
- 2020-01-15 CN CN202010043129.6A patent/CN111067838A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107242982A (en) * | 2017-06-07 | 2017-10-13 | 广州科玛生物科技股份有限公司 | A kind of fair-skinned bright Virgin's milk liquid and preparation method thereof |
| CN110292535A (en) * | 2019-07-15 | 2019-10-01 | 广州露思生物科技有限公司 | A kind of whitening and spot eliminating cream |
Non-Patent Citations (3)
| Title |
|---|
| 冯年平等: "《中药及功效性化妆品经皮给药技术》", 3 May 2019, 中国医药科技出版社 * |
| 法熙妃研肌亮肤霜: "青岛泉合化妆品有限公司", 《国产非特殊用途化妆品备案信息服务平台（HTTP://FTBA.NMPA.GOV.CN:8181/FTBAN/FW.JSP）》 * |
| 盛夏等: "《美容大王和化学家》", 31 August 2015, 安徽美术出版社 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111568847A (en) * | 2020-05-30 | 2020-08-25 | 杭州心悦化妆品有限公司 | Emulsion easy to be absorbed by skin and production process thereof |
| CN111544345A (en) * | 2020-06-05 | 2020-08-18 | 广州丽彦妆生物科技有限公司 | Production process of whitening and freckle-removing cream |
| CN111920740A (en) * | 2020-08-27 | 2020-11-13 | 名宇(广东)化妆品科技有限公司 | 377 whitening cream and preparation method thereof |
| CN114504528A (en) * | 2020-12-25 | 2022-05-17 | 邱天英 | Targeted freckle-removing and whitening face cream |
| CN113520958A (en) * | 2021-09-08 | 2021-10-22 | 赤峰万泽药业股份有限公司 | Whitening and freckle-removing essence cream, preparation method and application |
| CN115025012A (en) * | 2022-05-09 | 2022-09-09 | 河北康正药业有限公司 | Whitening and freckle-removing cream and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN111067838A (en) | Whitening and freckle-removing composition, whitening and freckle-removing cream and preparation method thereof | |
| KR101695002B1 (en) | Composition of skin external application containing propanoid derivatives | |
| KR20200026646A (en) | Cosmetic Composition for Improving Skin Condition Comprising Plant cell complex cultures to improve skin radiance and vitality | |
| CN103610633B (en) | Cosmetic combination containing Herba Herminii Pleurotus ferulae Lanzi fermentation liquid | |
| JP4567278B2 (en) | Skin cosmetics | |
| KR20140060928A (en) | Skin external composition containing thioredoxin | |
| KR101512606B1 (en) | Cosmetic composition for improving wrinkle and atopic dermatitis and moisturizing | |
| CN114748367A (en) | Moisturizing repair essence and preparation method thereof | |
| KR20030064059A (en) | Cosmetic composition containing paeonia suffruticosa andrews extract and albizzia julibrissin dura extract having anti-ageing effect | |
| CN113648257A (en) | Whitening and freckle-removing composition and preparation method and application thereof | |
| CN110101611B (en) | Vitamin A anhydrous emulsion and preparation method thereof | |
| CN102949328B (en) | Toning lotion with functions of anti-senile, wrinkle-dispelling and moisturizing and preparation method thereof | |
| KR20160146246A (en) | Composition for Anti-oxidation, Whitening and Wrinkles protection | |
| KR20130024316A (en) | Cosmetic composition for improving skin condition comprising growth factor and cytokine induced human placenta | |
| US10653615B2 (en) | Use of a photosynthetic cell extract comprising functional thylakoids in cosmetic compositions | |
| CN108392444A (en) | Micro- whole all-round aquation cosmetic of one kind and preparation method thereof | |
| CN112402342A (en) | Anti-aging cosmetic additive and preparation method thereof | |
| CN107260622B (en) | Granulation-promoting, wound-astringing, moisturizing and anti-cracking cream and preparation method thereof | |
| CN114886794B (en) | Composition with anti-inflammatory and antioxidant effects and application thereof | |
| CN107998017A (en) | A kind of anti-wrinkle containing Flos Osmanthi Fragrantis extract, cosmetic composition and preparation method thereof | |
| Natasia et al. | Test the Potential of Macadamia Nut Oil (Macadamia F. Muell) as Sunscreen in Cream Preparations in Vitro | |
| CN115363983B (en) | Gentiopicroside-eriocitrin compound and preparation method and application thereof | |
| WO1994003149A2 (en) | Lipid-soluble thioethers and dithioethers in cosmetic preparations to counteract aging of the human skin | |
| JP2000143527A (en) | Hyaluronic acid production promoter and skin preparation for external use containing the same | |
| CN116392429A (en) | Whitening and freckle-removing composition and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20200428 |