CN115737501A - Composition for rapidly repairing basement membrane band and reconstructing collagen and application - Google Patents
Composition for rapidly repairing basement membrane band and reconstructing collagen and application Download PDFInfo
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- CN115737501A CN115737501A CN202211461726.6A CN202211461726A CN115737501A CN 115737501 A CN115737501 A CN 115737501A CN 202211461726 A CN202211461726 A CN 202211461726A CN 115737501 A CN115737501 A CN 115737501A
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- 239000000203 mixture Substances 0.000 title claims abstract description 26
- 102000008186 Collagen Human genes 0.000 title claims abstract description 20
- 108010035532 Collagen Proteins 0.000 title claims abstract description 20
- 229920001436 collagen Polymers 0.000 title claims abstract description 20
- 210000002469 basement membrane Anatomy 0.000 title claims abstract description 12
- 239000002994 raw material Substances 0.000 claims abstract description 57
- 239000013078 crystal Substances 0.000 claims abstract description 20
- 239000000843 powder Substances 0.000 claims abstract description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 17
- 229920002385 Sodium hyaluronate Polymers 0.000 claims abstract description 15
- 229940010747 sodium hyaluronate Drugs 0.000 claims abstract description 15
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims abstract description 15
- 239000002904 solvent Substances 0.000 claims abstract description 14
- 239000007788 liquid Substances 0.000 claims abstract description 12
- 239000000463 material Substances 0.000 claims abstract description 9
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims abstract description 7
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims abstract description 6
- 229930195725 Mannitol Natural products 0.000 claims abstract description 6
- 239000000594 mannitol Substances 0.000 claims abstract description 6
- 235000010355 mannitol Nutrition 0.000 claims abstract description 6
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims abstract description 5
- 239000004475 Arginine Substances 0.000 claims abstract description 5
- 102000007562 Serum Albumin Human genes 0.000 claims abstract description 5
- 108010071390 Serum Albumin Proteins 0.000 claims abstract description 5
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims abstract description 5
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims abstract description 5
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims abstract description 5
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims abstract description 5
- 229910000403 monosodium phosphate Inorganic materials 0.000 claims abstract description 5
- 235000019799 monosodium phosphate Nutrition 0.000 claims abstract description 5
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 claims abstract description 5
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims abstract description 4
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims abstract description 4
- 239000011575 calcium Substances 0.000 claims abstract description 4
- 229910052791 calcium Inorganic materials 0.000 claims abstract description 4
- 238000000855 fermentation Methods 0.000 claims abstract description 4
- 230000004151 fermentation Effects 0.000 claims abstract description 4
- 238000003756 stirring Methods 0.000 claims description 18
- 229940015975 1,2-hexanediol Drugs 0.000 claims description 16
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 claims description 16
- TXFPEBPIARQUIG-UHFFFAOYSA-N 4'-hydroxyacetophenone Chemical compound CC(=O)C1=CC=C(O)C=C1 TXFPEBPIARQUIG-UHFFFAOYSA-N 0.000 claims description 12
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 9
- 238000001816 cooling Methods 0.000 claims description 9
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 8
- 238000002156 mixing Methods 0.000 claims description 8
- 238000007599 discharging Methods 0.000 claims description 6
- 230000001804 emulsifying effect Effects 0.000 claims description 6
- 238000004108 freeze drying Methods 0.000 claims description 6
- 238000007689 inspection Methods 0.000 claims description 6
- 238000004806 packaging method and process Methods 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 6
- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical compound CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 claims description 5
- 239000011780 sodium chloride Substances 0.000 claims description 4
- XPFCZYUVICHKDS-UHFFFAOYSA-N 3-methylbutane-1,3-diol Chemical compound CC(C)(O)CCO XPFCZYUVICHKDS-UHFFFAOYSA-N 0.000 claims description 3
- BNMGUJRJUUDLHW-HCZMHFOYSA-N Madecassoside Chemical compound O([C@@H]1[C@@H](CO)O[C@H]([C@@H]([C@H]1O)O)OC[C@H]1O[C@H]([C@@H]([C@@H](O)[C@@H]1O)O)OC(=O)[C@]12CC[C@H]([C@@H]([C@H]1C=1[C@@]([C@@]3(C[C@@H](O)[C@H]4[C@](C)(CO)[C@@H](O)[C@H](O)C[C@]4(C)[C@H]3CC=1)C)(C)CC2)C)C)[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O BNMGUJRJUUDLHW-HCZMHFOYSA-N 0.000 claims description 3
- BNMGUJRJUUDLHW-HLUHVYOBSA-N Madecassoside Natural products C[C@@H]1CC[C@@]2(CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)C[C@@H](O)[C@H](O)[C@@](C)(CO)[C@@H]5[C@H](O)C[C@@]34C)[C@@H]2[C@H]1C)C(=O)O[C@@H]6O[C@H](CO[C@@H]7O[C@H](CO)[C@@H](O[C@@H]8O[C@H](C)[C@H](O)[C@@H](O)[C@H]8O)[C@H](O)[C@H]7O)[C@@H](O)[C@H](O)[C@H]6O BNMGUJRJUUDLHW-HLUHVYOBSA-N 0.000 claims description 3
- QCYLIQBVLZBPNK-UHFFFAOYSA-N asiaticoside A Natural products O1C(C(=O)C(C)C)=CC(C)C(C2(C(OC(C)=O)CC34C5)C)C1CC2(C)C3CCC(C1(C)C)C45CCC1OC1OCC(O)C(O)C1O QCYLIQBVLZBPNK-UHFFFAOYSA-N 0.000 claims description 3
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 claims description 3
- 239000011363 dried mixture Substances 0.000 claims description 3
- 238000011049 filling Methods 0.000 claims description 3
- 238000001914 filtration Methods 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 3
- 229940090813 madecassoside Drugs 0.000 claims description 3
- 230000001953 sensory effect Effects 0.000 claims description 3
- 230000001954 sterilising effect Effects 0.000 claims description 3
- 239000000126 substance Substances 0.000 claims description 3
- 239000000049 pigment Substances 0.000 claims description 2
- 229940064064 purslane extract Drugs 0.000 claims description 2
- 238000007634 remodeling Methods 0.000 claims description 2
- RWLALWYNXFYRGW-UHFFFAOYSA-N 2-Ethyl-1,3-hexanediol Chemical compound CCCC(O)C(CC)CO RWLALWYNXFYRGW-UHFFFAOYSA-N 0.000 claims 1
- 229940059958 centella asiatica extract Drugs 0.000 claims 1
- 229960005082 etohexadiol Drugs 0.000 claims 1
- 230000003796 beauty Effects 0.000 abstract description 8
- 230000000694 effects Effects 0.000 abstract description 8
- 210000004027 cell Anatomy 0.000 abstract description 4
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 abstract description 2
- 239000011159 matrix material Substances 0.000 abstract description 2
- 230000008929 regeneration Effects 0.000 abstract description 2
- 238000011069 regeneration method Methods 0.000 abstract description 2
- 210000004927 skin cell Anatomy 0.000 abstract description 2
- 239000000758 substrate Substances 0.000 abstract description 2
- 230000004060 metabolic process Effects 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 16
- 244000146462 Centella asiatica Species 0.000 description 4
- 235000004032 Centella asiatica Nutrition 0.000 description 4
- 235000001855 Portulaca oleracea Nutrition 0.000 description 4
- 230000003020 moisturizing effect Effects 0.000 description 3
- 102000015636 Oligopeptides Human genes 0.000 description 2
- 108010038807 Oligopeptides Proteins 0.000 description 2
- 244000234609 Portulaca oleracea Species 0.000 description 2
- 241000219304 Portulacaceae Species 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- 230000001815 facial effect Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- OEIJHBUUFURJLI-UHFFFAOYSA-N octane-1,8-diol Chemical compound OCCCCCCCCO OEIJHBUUFURJLI-UHFFFAOYSA-N 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 239000004909 Moisturizer Substances 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000019522 cellular metabolic process Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- ACCCMOQWYVYDOT-UHFFFAOYSA-N hexane-1,1-diol Chemical compound CCCCCC(O)O ACCCMOQWYVYDOT-UHFFFAOYSA-N 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 210000004379 membrane Anatomy 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- -1 oligopeptide-1 Chemical compound 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
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- 230000036559 skin health Effects 0.000 description 1
- 231100000245 skin permeability Toxicity 0.000 description 1
- 125000000647 trehalose group Chemical group 0.000 description 1
Landscapes
- Cosmetics (AREA)
Abstract
The invention discloses a composition for rapidly repairing a basement membrane band and reconstructing collagen and application thereof, wherein the composition comprises: face-beautifying freeze-dried powder and face-beautifying solvent solution, wherein: the face-beautifying freeze-dried powder comprises the following components in percentage by weight: 96.31% of water, 2.5% of mannitol, 0.7% of oligopeptide-1, 0.2% of sodium dihydrogen phosphate, 0.2% of disodium hydrogen phosphate, 0.03% of serum albumin, 0.03% of yeast/calcium fermentation product, 0.02% of mixed material A and 0.01% of hydrolyzed sodium hyaluronate; the crystal face solvent liquid comprises the following components in percentage by weight: 89.81% of water, 5% of the first raw material, 2% of butanediol, 2% of the second raw material and 0.5% of the third raw material; the invention can promote the skin cell repair by adopting the trehalose and arginine raw materials, realize the safe permeation effect, further achieve the effects of repairing the substrate and maintaining beauty, greatly reduce the beauty risk, simultaneously promote the cell regeneration, accelerate the repair of the matrix layer, enhance the metabolism of the cell newcastle of the user and further lighten the beauty effect.
Description
Technical Field
The invention relates to the technical field of beauty repair, in particular to a composition for quickly repairing a basement membrane zone and reconstructing collagen and application thereof.
Background
With the rapid development of economy, people pay more and more attention to the management of skin health, more and more people seek skin beautification and personal skin care, especially women, so the beauty industry is developed at a high speed, meanwhile, the beauty industry also has a plurality of uneven skin care and repair products, which causes great troubles to users, and how to correctly and conveniently select a product for repairing skin without losing health becomes a topic which is always popular among people.
Many cosmetic repair products are on the market at present, but the components and the effects of the products are not known to users, the skin condition of the users is not known, so that the skin of the users is easy to be injured and even damaged irreversibly, and the products are forbidden by many users.
To this end, we developed a composition that enables rapid repair of the basement membrane band, remodeling collagen, of the skin of the user.
Disclosure of Invention
Aiming at the defects of the prior art, the invention provides a composition for quickly repairing a basal membrane strip and reconstructing collagen and application thereof, solves the problems that most of existing repairing products are not safe enough and cause allergy and injury to users, and can obviously repair the skin of users, and the specific scheme is as follows:
the method comprises the following steps: brilliant face freeze-dried powder and brilliant face solution medium, wherein:
the face-beautifying freeze-dried powder comprises the following components in percentage by weight: 96.31% of water, 2.5% of mannitol, 0.7% of oligopeptide-1, 0.2% of sodium dihydrogen phosphate, 0.2% of disodium hydrogen phosphate, 0.03% of serum albumin, 0.03% of yeast/calcium fermentation product, 0.02% of mixed material A and 0.01% of hydrolyzed sodium hyaluronate;
the mixed material A comprises the following components in percentage by weight: 86.064% water, 10% trehalose, 1.742% arginine, 1.3% 1, 2-hexanediol, 0.5% 1, 2-pentanediol, 0.1% sodium chloride;
the face crystal solvent liquid comprises the following components in percentage by weight: 89.81% of water, 5% of the first raw material, 2% of butanediol, 2% of the second raw material, 0.5% of the third raw material, 0.5% of 1, 2-hexanediol, 0.1% of the fourth raw material, 0.03% of soluble collagen and 0.06% of sodium hyaluronate;
the first raw material comprises the following components in percentage by weight: 99.5% glycerol and 0.5% water;
the second raw material comprises the following components in percentage by weight: 99% of purslane (Portulaca OLERACEA) extract, 0.5% of p-hydroxyacetophenone, and 0.5% of 1, 2-hexanediol;
the third raw material comprises the following components in percentage by weight: 51% of dipropylene glycol, 27% of p-hydroxyacetophenone, 11% of 1, 2-hexanediol, 8% of octanediol, and 3% of isoprene glycol;
the fourth raw material comprises the following components in percentage by weight: 85% of madecassoside and 15% of CENTELLA ASIATICA (CENTELLA ASIATICA) extract;
the application steps of the composition for rapidly repairing basement membrane band and reconstructing collagen comprise:
1) Fully mixing and dissolving the face crystal freeze-dried powder and the face crystal solvent liquid;
2) Applying 3-10 g of the mixture obtained in the step 1) to skin;
3) Massaging gently for 1-2 min until it is absorbed uniformly and sufficiently.
Further, the preparation method of the crystal face freeze-dried powder comprises the following steps:
1) All the component raw materials in the face-beautifying freeze-dried powder are mixed into a clean stirring pot for preliminary stirring and dissolution;
2) Sterilizing and filtering the mixture obtained in the step 1) by 0.22 um;
3) Freeze-drying according to a freeze-drying curve;
4) Taking out the freeze-dried mixture and capping the mixture to 2-5 mm width;
5) Performing light inspection;
6) And finally, packaging is completed.
Further, the preparation step of the crystal pigment solvent liquid comprises the following steps:
1) Adding water in a crystal face solvent liquid formula into an emulsifying pot according to the proportion, and heating to 85 ℃;
2) Mixing, dissolving and dispersing a first raw material, a third raw material and 1, 2-hexanediol in the raw materials, adding into the emulsifying pot in the step 1), stirring until the raw materials are completely and uniformly dissolved, and keeping the temperature at 85 ℃ for 20 minutes;
3) Cooling to 55 ℃, adding butanediol and sodium hyaluronate in the raw materials, and uniformly stirring;
4) Cooling to below 45 ℃, adding the second raw material, the fourth raw material, the soluble collagen and the sodium hyaluronate into the raw materials, and stirring until the second raw material, the fourth raw material, the soluble collagen and the sodium hyaluronate are completely dissolved;
5) Stirring and cooling to 30 ℃, informing a laboratory to detect sensory physical and chemical indexes, discharging through a 300-mesh steel-impermeable filter:
6) And after the discharging inspection is qualified, filling and packaging the finished product.
The beneficial effects of the invention include: the invention can promote the skin cell repair by adopting the raw materials of trehalose, arginine, 1, 2-hexanediol, 1, 2-pentanediol, sodium chloride, mannitol, oligopeptide-1, sodium dihydrogen phosphate, disodium hydrogen phosphate, serum albumin and the like, realize the safe permeation effect, further achieve the effects of repairing a substrate and beautifying, greatly reduce the beauty risk, simultaneously promote the cell regeneration, accelerate the repair of a matrix layer, enhance the metabolism of cells in a Newcastle of a user and further lighten the beauty effect.
Detailed Description
In order that the objects and advantages of the invention will be more clearly understood, the invention is further described below with reference to examples; it should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
Preferred embodiments of the present invention are described below. It should be understood by those skilled in the art that these embodiments are only for explaining the technical principle of the present invention, and do not limit the scope of the present invention.
The invention provides a composition for rapidly repairing a basement membrane zone and reconstructing collagen and application thereof, and the specific scheme is as follows:
the method comprises the following steps: brilliant face freeze-dried powder and brilliant face solution medium, wherein:
the crystallized skin freeze-dried powder comprises the following components in percentage by weight: 96.31% of water, 2.5% of mannitol, 0.7% of oligopeptide-1, 0.2% of sodium dihydrogen phosphate, 0.2% of disodium hydrogen phosphate, 0.03% of serum albumin, 0.03% of yeast/calcium fermentation product, 0.02% of mixed material A and 0.01% of hydrolyzed sodium hyaluronate;
wherein mannitol can effectively improve moisture retention of the composition, and oligopeptide with small oligopeptide molecular weight has higher skin permeability than polypeptide and is easier to be absorbed by human skin.
The mixed material A comprises the following components in percentage by weight: 86.064% water, 10% trehalose, 1.742% arginine, 1.3% 1, 2-hexanediol, 0.5% 1, 2-pentanediol, 0.1% sodium chloride;
wherein, the trehalose forms a unique protective film on the cell surface, thereby effectively protecting the biological molecular structure from being damaged.
Wherein the hexanediol and the 1, 2-pentanediol are used as the humectant and can stay on the skin, absorb moisture in the air and prevent the moisture from volatilizing, and the skin feels cool when the moisturizer is used.
The crystal face solvent liquid comprises the following components in percentage by weight: 89.81% of water, 5% of the first raw material, 2% of butanediol, 2% of the second raw material, 0.5% of the third raw material, 0.5% of 1, 2-hexanediol, 0.1% of the fourth raw material, 0.03% of soluble collagen and 0.06% of sodium hyaluronate;
among them, the moisturizing effect is the most important effect of sodium hyaluronate in cosmetics, and the relative humidity of the surrounding environment has less influence on the moisturizing effect than other moisturizing agents.
The first raw material comprises the following components in percentage by weight: 99.5% glycerol and 0.5% water;
the second raw material comprises the following components in percentage by weight: 99% of purslane (Portulaca OLERACEA) extract, 0.5% of p-hydroxyacetophenone, and 0.5% of 1, 2-hexanediol;
the purslane extract can prevent dryness and aging, increase the comfort level of the skin, remove free radicals, improve the comprehensive performance of the skin, and the like.
The third raw material comprises the following components in percentage by weight: 51% of dipropylene glycol, 27% of p-hydroxyacetophenone, 11% of 1, 2-hexanediol, 8% of octanediol, and 3% of isoprene glycol;
the fourth raw material comprises the following components in percentage by weight: 85% of madecassoside and 15% of CENTELLA ASIATICA (CENTELLA ASIATICA) extract;
the application steps of the composition for rapidly repairing the basement membrane band and reconstructing the collagen comprise:
1) Fully mixing and dissolving the facial crystal freeze-dried powder and the facial crystal solvent liquid;
2) Applying 3-10 g of the mixture obtained in the step 1) to skin;
3) Gently massaging for 1-2 min until uniformly and sufficiently absorbing.
Further, the preparation method of the crystal face freeze-dried powder comprises the following steps:
1) Mixing all the component raw materials in the crystal face freeze-dried powder into a clean stirring pot for preliminary stirring and dissolving;
2) Sterilizing and filtering the mixture obtained in the step 1) by 0.22 um;
3) Freeze-drying according to a freeze-drying curve;
4) Taking out the freeze-dried mixture and capping the mixture to 2-5 mm width;
5) Performing light inspection;
6) And finally, packaging is completed.
Further, the preparation method of the crystal face solvent liquid comprises the following steps:
1) Adding water in a crystal face solvent liquid formula into an emulsifying pot according to the proportion, and heating to 85 ℃;
2) Mixing, dissolving and dispersing a first raw material, a third raw material and 1, 2-hexanediol in the raw materials, adding into the emulsifying pot in the step 1), stirring until the raw materials are completely and uniformly dissolved, and keeping the temperature at 85 ℃ for 20 minutes;
3) Cooling to 55 ℃, adding butanediol and sodium hyaluronate in the raw materials, and uniformly stirring;
4) Cooling to below 45 ℃, adding the second raw material, the fourth raw material, the soluble collagen and the sodium hyaluronate into the raw materials, and stirring until the materials are completely dissolved;
5) Stirring and cooling to 30 ℃, informing a laboratory to detect sensory physical and chemical indexes, and discharging through a 300-mesh steel-impermeable filter;
6) And after the discharging inspection is qualified, filling and packaging the finished product.
So far, the technical solutions of the present invention have been described in connection with the preferred embodiments, but it is easily understood by those skilled in the art that the scope of the present invention is obviously not limited to these specific embodiments. Equivalent changes or substitutions of related technical features can be made by those skilled in the art without departing from the principle of the invention, and the technical scheme after the changes or substitutions can be within the protection scope of the invention.
Claims (4)
1. A composition for rapid repair of basement membrane bands, remodeling collagen, comprising: brilliant face freeze-dried powder and brilliant face solution medium, wherein:
the face-beautifying freeze-dried powder comprises the following components in percentage by weight: 96.31% of water, 2.5% of mannitol, 0.7% of oligopeptide-1, 0.2% of sodium dihydrogen phosphate, 0.2% of disodium hydrogen phosphate, 0.03% of serum albumin, 0.03% of yeast/calcium fermentation product, 0.02% of mixed material A and 0.01% of hydrolyzed sodium hyaluronate;
the crystal face solvent liquid comprises the following components in percentage by weight: 89.81% of water, 5% of the first raw material, 2% of butanediol, 2% of the second raw material, 0.5% of the third raw material, 0.5% of 1, 2-hexanediol, 0.1% of the fourth raw material, 0.03% of soluble collagen and 0.06% of sodium hyaluronate;
the mixed material A comprises the following components in percentage by weight: 86.064% water, 10% trehalose, 1.742% arginine, 1.3% 1, 2-hexanediol, 0.5% 1, 2-pentanediol, 0.1% sodium chloride;
the first raw material comprises the following components in percentage by weight: 99.5% glycerol and 0.5% water;
the second raw material comprises the following components in percentage by weight: 99% of purslane extract, 0.5% of p-hydroxyacetophenone and 0.5% of 1, 2-hexanediol;
the third raw material comprises the following components in percentage by weight: 51% of dipropylene glycol, 27% of p-hydroxyacetophenone, 11% of 1, 2-hexanediol, 8% of octylene glycol and 3% of isoprene glycol;
the fourth raw material comprises the following components in percentage by weight: 85% of madecassoside and 15% of centella asiatica extract.
2. The application of the composition for rapidly repairing basement membrane band and reconstructing collagen according to claim 1 comprises:
1) Fully mixing and dissolving the face crystal freeze-dried powder and the face crystal solvent liquid;
2) Applying 3-10 g of the mixture obtained in the step 1) to skin;
3) Massaging gently for 1-2 min until it is absorbed uniformly and sufficiently.
3. The composition for rapidly repairing basement membrane zone and reconstructing collagen according to claim 1, wherein the preparation steps of the crystal-face freeze-dried powder comprise:
1) Mixing all the component raw materials in the crystal face freeze-dried powder into a clean stirring pot for preliminary stirring and dissolving;
2) Sterilizing and filtering the mixture obtained in the step 1) by 0.22 um;
3) Freeze-drying according to a freeze-drying curve;
4) Taking out the freeze-dried mixture and capping the mixture to 2-5 mm width;
5) Performing light inspection;
6) And finally, packaging is finished.
4. The composition for rapidly repairing basement membrane band and reconstructing collagen according to claim 1, wherein the preparation step of the crystal pigment solvent solution comprises:
1) Adding water in a crystal face solvent liquid formula into an emulsifying pot according to the proportion, and heating to 85 ℃;
2) Mixing, dissolving and dispersing a first raw material, a third raw material and 1, 2-hexanediol in the raw materials, adding the mixture into the emulsifying pot in the step 1), stirring until the mixture is completely and uniformly dissolved, and keeping the temperature at 85 ℃ for 20 minutes;
3) Cooling to 55 ℃, adding butanediol and sodium hyaluronate in the raw materials, and uniformly stirring;
4) Cooling to below 45 ℃, adding the second raw material, the fourth raw material, the soluble collagen and the sodium hyaluronate into the raw materials, and stirring until the materials are completely dissolved;
5) Stirring and cooling to 30 ℃, informing a laboratory to detect sensory physical and chemical indexes, and discharging through a 300-mesh impermeable rigid filter;
6) And after the discharging inspection is qualified, filling and packaging the finished product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211461726.6A CN115737501A (en) | 2022-11-16 | 2022-11-16 | Composition for rapidly repairing basement membrane band and reconstructing collagen and application |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211461726.6A CN115737501A (en) | 2022-11-16 | 2022-11-16 | Composition for rapidly repairing basement membrane band and reconstructing collagen and application |
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| CN115737501A true CN115737501A (en) | 2023-03-07 |
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| CN202211461726.6A Pending CN115737501A (en) | 2022-11-16 | 2022-11-16 | Composition for rapidly repairing basement membrane band and reconstructing collagen and application |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105456050A (en) * | 2015-12-31 | 2016-04-06 | 青岛美博生物技术有限公司 | Freeze-dried powder, essence and skincare set for repairing acne marks and scars |
| CN111329771A (en) * | 2020-02-10 | 2020-06-26 | 天津丽杰美经科技有限公司 | Skin-protecting and face-refreshing essence and preparation method thereof |
| CN111888459A (en) * | 2020-08-18 | 2020-11-06 | 深圳市俊元生物科技有限公司 | Lyophilized powder containing mesenchymal stem cell secretory factor and solvent thereof |
| CN114748367A (en) * | 2022-05-18 | 2022-07-15 | 赵莉 | Moisturizing repair essence and preparation method thereof |
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2022
- 2022-11-16 CN CN202211461726.6A patent/CN115737501A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105456050A (en) * | 2015-12-31 | 2016-04-06 | 青岛美博生物技术有限公司 | Freeze-dried powder, essence and skincare set for repairing acne marks and scars |
| CN111329771A (en) * | 2020-02-10 | 2020-06-26 | 天津丽杰美经科技有限公司 | Skin-protecting and face-refreshing essence and preparation method thereof |
| CN111888459A (en) * | 2020-08-18 | 2020-11-06 | 深圳市俊元生物科技有限公司 | Lyophilized powder containing mesenchymal stem cell secretory factor and solvent thereof |
| CN114748367A (en) * | 2022-05-18 | 2022-07-15 | 赵莉 | Moisturizing repair essence and preparation method thereof |
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