CN115024991B - Anti-aging composition and preparation method and application thereof - Google Patents
Anti-aging composition and preparation method and application thereof Download PDFInfo
- Publication number
- CN115024991B CN115024991B CN202210895828.2A CN202210895828A CN115024991B CN 115024991 B CN115024991 B CN 115024991B CN 202210895828 A CN202210895828 A CN 202210895828A CN 115024991 B CN115024991 B CN 115024991B
- Authority
- CN
- China
- Prior art keywords
- percent
- aging composition
- aging
- skin
- retinol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 230000003712 anti-aging effect Effects 0.000 title claims abstract description 65
- 239000000203 mixture Substances 0.000 title claims abstract description 49
- 238000002360 preparation method Methods 0.000 title claims abstract description 8
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims abstract description 56
- 239000000284 extract Substances 0.000 claims abstract description 40
- TXFPEBPIARQUIG-UHFFFAOYSA-N 4'-hydroxyacetophenone Chemical compound CC(=O)C1=CC=C(O)C=C1 TXFPEBPIARQUIG-UHFFFAOYSA-N 0.000 claims abstract description 30
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims abstract description 28
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 claims abstract description 28
- 229960003471 retinol Drugs 0.000 claims abstract description 28
- 235000020944 retinol Nutrition 0.000 claims abstract description 28
- 239000011607 retinol Substances 0.000 claims abstract description 28
- 241000196324 Embryophyta Species 0.000 claims abstract description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 22
- 229940041514 candida albicans extract Drugs 0.000 claims abstract description 21
- 239000012138 yeast extract Substances 0.000 claims abstract description 21
- 150000001875 compounds Chemical class 0.000 claims abstract description 20
- 239000000654 additive Substances 0.000 claims abstract description 19
- 235000003956 Luffa Nutrition 0.000 claims abstract description 18
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 15
- 229960001295 tocopherol Drugs 0.000 claims abstract description 15
- 229930003799 tocopherol Natural products 0.000 claims abstract description 15
- 235000010384 tocopherol Nutrition 0.000 claims abstract description 15
- 239000011732 tocopherol Substances 0.000 claims abstract description 15
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims abstract description 15
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 claims abstract description 14
- 229960000458 allantoin Drugs 0.000 claims abstract description 14
- 239000000043 antiallergic agent Substances 0.000 claims abstract description 4
- 244000050983 Luffa operculata Species 0.000 claims abstract 6
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 14
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 14
- 238000003756 stirring Methods 0.000 claims description 14
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims description 12
- 239000000047 product Substances 0.000 claims description 12
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical class OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 11
- 229940008099 dimethicone Drugs 0.000 claims description 11
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 9
- BANXPJUEBPWEOT-UHFFFAOYSA-N 2-methyl-Pentadecane Chemical compound CCCCCCCCCCCCCC(C)C BANXPJUEBPWEOT-UHFFFAOYSA-N 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 8
- 238000002156 mixing Methods 0.000 claims description 8
- 229940015975 1,2-hexanediol Drugs 0.000 claims description 7
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical class CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 claims description 7
- 238000001816 cooling Methods 0.000 claims description 6
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Chemical class C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims description 5
- 229940090898 Desensitizer Drugs 0.000 claims description 5
- LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 claims description 5
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical class C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 claims description 5
- 229920002385 Sodium hyaluronate Chemical class 0.000 claims description 5
- 229960003237 betaine Drugs 0.000 claims description 5
- 150000001720 carbohydrates Chemical class 0.000 claims description 5
- 235000011187 glycerol Nutrition 0.000 claims description 5
- 229940010747 sodium hyaluronate Drugs 0.000 claims description 5
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical class [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 5
- 239000000230 xanthan gum Substances 0.000 claims description 5
- 235000010493 xanthan gum Nutrition 0.000 claims description 5
- 229920001285 xanthan gum Polymers 0.000 claims description 5
- 229940082509 xanthan gum Drugs 0.000 claims description 5
- 229940043268 2,2,4,4,6,8,8-heptamethylnonane Drugs 0.000 claims description 4
- 244000146462 Centella asiatica Species 0.000 claims description 4
- 235000004032 Centella asiatica Nutrition 0.000 claims description 4
- 244000303040 Glycyrrhiza glabra Species 0.000 claims description 4
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims description 4
- 244000042664 Matricaria chamomilla Species 0.000 claims description 4
- 235000007232 Matricaria chamomilla Nutrition 0.000 claims description 4
- 240000001341 Reynoutria japonica Species 0.000 claims description 4
- 235000018167 Reynoutria japonica Nutrition 0.000 claims description 4
- 244000178231 Rosmarinus officinalis Species 0.000 claims description 4
- 240000004534 Scutellaria baicalensis Species 0.000 claims description 4
- 235000017089 Scutellaria baicalensis Nutrition 0.000 claims description 4
- 244000269722 Thea sinensis Species 0.000 claims description 4
- 239000002738 chelating agent Substances 0.000 claims description 4
- 239000003995 emulsifying agent Substances 0.000 claims description 4
- KUVMKLCGXIYSNH-UHFFFAOYSA-N isopentadecane Natural products CCCCCCCCCCCCC(C)C KUVMKLCGXIYSNH-UHFFFAOYSA-N 0.000 claims description 4
- 239000003607 modifier Substances 0.000 claims description 4
- RGUVUPQQFXCJFC-UHFFFAOYSA-N n-hydroxyoctanamide Chemical compound CCCCCCCC(=O)NO RGUVUPQQFXCJFC-UHFFFAOYSA-N 0.000 claims description 4
- 239000003755 preservative agent Substances 0.000 claims description 4
- 239000003381 stabilizer Substances 0.000 claims description 4
- 239000000725 suspension Substances 0.000 claims description 4
- GHBFNMLVSPCDGN-UHFFFAOYSA-N caprylic acid monoglyceride Natural products CCCCCCCC(=O)OCC(O)CO GHBFNMLVSPCDGN-UHFFFAOYSA-N 0.000 claims description 3
- 235000010418 carrageenan Nutrition 0.000 claims description 3
- 229920001577 copolymer Polymers 0.000 claims description 3
- VWPOBUVSGMLNCM-UHFFFAOYSA-L disodium prop-2-enoate Chemical compound [Na+].C(C=C)(=O)[O-].[Na+].C(C=C)(=O)[O-] VWPOBUVSGMLNCM-UHFFFAOYSA-L 0.000 claims description 3
- 230000002335 preservative effect Effects 0.000 claims description 3
- 229940104261 taurate Drugs 0.000 claims description 3
- 235000007866 Chamaemelum nobile Nutrition 0.000 claims description 2
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 claims description 2
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical group [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims description 2
- 239000004909 Moisturizer Substances 0.000 claims description 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims description 2
- 235000006468 Thea sinensis Nutrition 0.000 claims description 2
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims description 2
- 239000000679 carrageenan Substances 0.000 claims description 2
- 229920001525 carrageenan Polymers 0.000 claims description 2
- 229940113118 carrageenan Drugs 0.000 claims description 2
- 239000006071 cream Substances 0.000 claims description 2
- 229920006037 cross link polymer Polymers 0.000 claims description 2
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 claims description 2
- POULHZVOKOAJMA-UHFFFAOYSA-M dodecanoate Chemical compound CCCCCCCCCCCC([O-])=O POULHZVOKOAJMA-UHFFFAOYSA-M 0.000 claims description 2
- 238000000855 fermentation Methods 0.000 claims description 2
- 230000004151 fermentation Effects 0.000 claims description 2
- 239000000706 filtrate Substances 0.000 claims description 2
- 229960005150 glycerol Drugs 0.000 claims description 2
- 239000003906 humectant Substances 0.000 claims description 2
- 229940070765 laurate Drugs 0.000 claims description 2
- 239000006166 lysate Substances 0.000 claims description 2
- 230000001333 moisturizer Effects 0.000 claims description 2
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims description 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 2
- 229940068968 polysorbate 80 Drugs 0.000 claims description 2
- 229920000053 polysorbate 80 Polymers 0.000 claims description 2
- 235000015639 rosmarinus officinalis Nutrition 0.000 claims description 2
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims description 2
- 239000000686 essence Substances 0.000 claims 2
- 239000002131 composite material Substances 0.000 claims 1
- 210000003491 skin Anatomy 0.000 abstract description 35
- 230000000694 effects Effects 0.000 abstract description 19
- 239000003963 antioxidant agent Substances 0.000 abstract description 10
- 230000003078 antioxidant effect Effects 0.000 abstract description 9
- 235000006708 antioxidants Nutrition 0.000 abstract description 9
- 239000000126 substance Substances 0.000 abstract description 6
- 230000004060 metabolic process Effects 0.000 abstract description 5
- 239000002085 irritant Substances 0.000 abstract description 4
- 231100000021 irritant Toxicity 0.000 abstract description 4
- 210000000434 stratum corneum Anatomy 0.000 abstract description 4
- 229930014626 natural product Natural products 0.000 abstract description 3
- 241000219138 Luffa Species 0.000 description 12
- 230000000052 comparative effect Effects 0.000 description 12
- 230000037303 wrinkles Effects 0.000 description 8
- 210000004027 cell Anatomy 0.000 description 7
- 230000032683 aging Effects 0.000 description 6
- 230000007794 irritation Effects 0.000 description 6
- 230000001804 emulsifying effect Effects 0.000 description 4
- 238000010438 heat treatment Methods 0.000 description 4
- LXAHHHIGZXPRKQ-UHFFFAOYSA-N 5-fluoro-2-methylpyridine Chemical compound CC1=CC=C(F)C=N1 LXAHHHIGZXPRKQ-UHFFFAOYSA-N 0.000 description 3
- 206010051246 Photodermatosis Diseases 0.000 description 3
- 210000002615 epidermis Anatomy 0.000 description 3
- 239000003205 fragrance Substances 0.000 description 3
- 230000008845 photoaging Effects 0.000 description 3
- -1 polydimethylsiloxane Polymers 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 230000009759 skin aging Effects 0.000 description 3
- 210000004927 skin cell Anatomy 0.000 description 3
- ZKHQWZAMYRWXGA-UHFFFAOYSA-N Adenosine triphosphate Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C(O)C1O ZKHQWZAMYRWXGA-UHFFFAOYSA-N 0.000 description 2
- 102000008186 Collagen Human genes 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
- 206010012438 Dermatitis atopic Diseases 0.000 description 2
- 102000016942 Elastin Human genes 0.000 description 2
- 108010014258 Elastin Proteins 0.000 description 2
- 241000428813 Gomphrena Species 0.000 description 2
- 206010070834 Sensitisation Diseases 0.000 description 2
- 201000008937 atopic dermatitis Diseases 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 229920001436 collagen Polymers 0.000 description 2
- 210000004207 dermis Anatomy 0.000 description 2
- 229920002549 elastin Polymers 0.000 description 2
- 230000001815 facial effect Effects 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 239000000049 pigment Substances 0.000 description 2
- 230000019612 pigmentation Effects 0.000 description 2
- 230000037394 skin elasticity Effects 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- ZKHQWZAMYRWXGA-KQYNXXCUSA-J ATP(4-) Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)[C@H]1O ZKHQWZAMYRWXGA-KQYNXXCUSA-J 0.000 description 1
- 241000206575 Chondrus crispus Species 0.000 description 1
- 240000001980 Cucurbita pepo Species 0.000 description 1
- 235000009852 Cucurbita pepo Nutrition 0.000 description 1
- 229920000832 Cutin Polymers 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 244000178870 Lavandula angustifolia Species 0.000 description 1
- 235000010663 Lavandula angustifolia Nutrition 0.000 description 1
- 244000302544 Luffa aegyptiaca Species 0.000 description 1
- 235000009814 Luffa aegyptiaca Nutrition 0.000 description 1
- 206010040799 Skin atrophy Diseases 0.000 description 1
- 206010040849 Skin fissures Diseases 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 102000003425 Tyrosinase Human genes 0.000 description 1
- 108060008724 Tyrosinase Proteins 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000003266 anti-allergic effect Effects 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 235000021028 berry Nutrition 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 229940074992 chondrus crispus extract Drugs 0.000 description 1
- 230000002301 combined effect Effects 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 201000010251 cutis laxa Diseases 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 210000004177 elastic tissue Anatomy 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 206010020718 hyperplasia Diseases 0.000 description 1
- 210000004969 inflammatory cell Anatomy 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 239000001102 lavandula vera Substances 0.000 description 1
- 235000018219 lavender Nutrition 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 210000002752 melanocyte Anatomy 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000004089 microcirculation Effects 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 235000011837 pasties Nutrition 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 230000037307 sensitive skin Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 230000008591 skin barrier function Effects 0.000 description 1
- 230000037380 skin damage Effects 0.000 description 1
- 230000037393 skin firmness Effects 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 230000000391 smoking effect Effects 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 208000009056 telangiectasis Diseases 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 230000008467 tissue growth Effects 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Abstract
The invention provides an anti-aging composition, a preparation method and application thereof. The anti-aging composition comprises the following components in percentage by weight: 0.2 to 0.5 percent of p-hydroxyacetophenone, 0.05 to 0.2 percent of allantoin, 0.05 to 1.0 percent of retinol, 0.05 to 0.3 percent of tocopherol, 1 to 99 percent of yeast extract, 0.1 to 2.0 percent of luffa root extract, 0.1 to 5 percent of calmYang compound plant sensitizer, 0 to 57.5 percent of other additives and the balance of water. The invention can energize cells to the metabolism of the stratum corneum through reasonable collocation among retinol, luffa root extract, yeast extract and calmYang compound plant anti-allergic agent, and can realize the anti-aging effect in different layers from inside to outside in an all-around way, so that the anti-aging effect is more remarkable. And the natural product extracts are adopted, and the skin care composition does not contain irritant antioxidant chemical substances and has mild effect on the skin.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to an anti-aging composition, a preparation method and application thereof.
Background
Aging is performed at any time, and the main characteristics are wrinkles, loose skin, dry and rough skin, loss of skin elasticity, pigmentation and the like. Whereas skin aging is concurrent with body aging, skin aging is part of body aging. Because the skin is located in the outermost layer of the body, and is more affected by exogenous factors, aging of the skin is the result of the combined effects of endogenous and exogenous factors.
Extrinsic aging of the skin is associated with exposure to ultraviolet light, wind, smoking, drinking, and exposure to irritants. Whereas long-term irradiation of ultraviolet light is the most dominant factor in the environment promoting skin aging, exogenous aging is generally referred to as photoaging. Photoaging is characterized clinically and histologically. The clinical manifestations are mainly: the skin at the exposed part is loose, rough and deep wrinkles, nodules and leather-like appearance, pigment spots are increased, capillary blood vessels are expanded, the appearance of the original geometric figure is changed or disappears, the skin color is always gray yellow, and various benign, precancerous or malignant tumors can occur. Photoaged skin is mainly histologically represented by: inflammatory cells of the dermis layer infiltrate, thickening, disordered arrangement or aggregation of elastic fibers, collagen degeneration detail of the upper layer of the dermis layer, and finally forming an amorphous substance; the skin telangiectases and twists, and finally becomes extremely sparse, melanocyte focal hyperplasia, etc. Many changes in photoaged skin, such as coarse wrinkles, skin roughness, pigmentation, etc., are possible through pharmaceutical improvements and inversions, to treat and prevent photoaging of the skin.
Therefore, many antioxidant and anti-aging skin care products and health care products are presented, but in the existing anti-aging skin care products, in order to improve the anti-aging effect, a large amount of artificially synthesized antioxidant additives are usually added, and the addition of the additives can generate certain irritation to the skin, so that although people aim to develop pure natural antioxidant products with better antioxidant performance, the antioxidant and anti-aging performances of the existing products still need to be improved.
Disclosure of Invention
The invention aims to overcome the defects that the existing anti-aging product has larger irritation and the anti-aging performance needs to be further improved, and provides an anti-aging composition which is mild to skin and has obvious anti-aging effect. The invention has good anti-aging effect under a small addition amount by the synergistic effect among retinol, yeast extract and towel gourd extract, and has mild effect and no irritation to skin.
It is another object of the present invention to provide a method for preparing the anti-aging composition.
It is another object of the present invention to provide the use of said anti-aging composition for the preparation of skin care products.
In order to achieve the above purpose, the invention adopts the following technical scheme:
an anti-aging composition comprising the following components in weight percent:
0.2 to 0.5 percent of p-hydroxyacetophenone, 0.05 to 0.2 percent of allantoin, 0.05 to 1.0 percent of retinol, 0.05 to 0.3 percent of tocopherol, 1 to 99 percent of yeast extract, 0.1 to 2.0 percent of luffa root extract, 0.1 to 5 percent of calmYang compound plant sensitizer, 0 to 57.5 percent of other additives and the balance of water.
In the anti-aging composition, the balance of water is water added to 100%.
Retinol helps skin cells create better and healthier skin cells, provides antioxidant support, and increases the content of substances that strengthen the skin structure. Retinol has the functions of regulating metabolism of epidermis and horny layer, and can lighten pigment of epidermis and reduce injured or aged skin cells. It helps to improve the morphology of elastin already in the skin, and few studies have found that it helps to produce elastin, although it may also promote the production of more collagen. Some people cannot tolerate retinol, the retinol in a free state is poor in stability, the retinol is wrapped in a double layer manner by Salvona in the U.S. A, the wrapping technology solves the problems of poor stability and intolerance of the retinol, the retinol can be released on the skin more slowly and controllably, the retinol can be absorbed more easily, the irritation risk is avoided to the greatest extent, the retinol can stay on the skin mildly and for a long time, and the effect is better exerted.
The LUFFA CYLINDRICA root extract can energize cells, restart energy production, ensure the generation of enough ATP (adenosine triphosphate, raw material for nucleotide synthesis) and ensure the renewal of skin matrix, thereby leading the cells to be younger and more viable and further showing higher skin elasticity and skin firmness.
The calmlyang compound plant desensitizer consists of butanediol, water, centella asiatica (CENTELLA ASIATICA) extracts, polygonum cuspidatum (POLYGONUM CUSPIDATUM) root extracts, scutellaria baicalensis (SCUTELLARIA BAICALENSIS) root extracts, tea (CAMELLIA SINENSIS) leaf extracts, glycyrrhiza glabra (GLYCYRRHIZA GLABRA) root extracts, chamomile (CHAMOMILLA RECUTITA) flower extracts and rosemary (ROSMARINUS OFFICINALIS) leaf extracts, is a compound plant desensitizer of 7 natural plants with therapeutic effect, has good effect of repairing skin barrier and has excellent effect on inhibiting inflammatory factors. The calmYang not only can repair the skin damage caused by the Atopic Dermatitis (AD), but also has good effects on the anti-sensitization, anti-sensitization and the hormone-dependent dermatitis treatment of sensitive skin.
The yeast extract, namely yeast fermentation lysate filtrate, has the effects of moisturizing and repairing, and can improve skin elasticity and promote skin microcirculation; it is rich in natural amino acids, and has effects in inhibiting tyrosinase activity and whitening skin.
The invention can energize cells to the metabolism of the stratum corneum through reasonable collocation among retinol, luffa root extract, yeast extract and calmYang compound plant anti-allergic agent, and can realize the anti-aging effect in different layers from inside to outside in an all-around way, so that the anti-aging effect is more remarkable. And the natural product extracts are adopted, and the skin care composition does not contain irritant antioxidant chemical substances and has mild effect on the skin.
Allantoin has antiallergic effect, and can relieve skin irritation caused by active substances, promote cell tissue growth, accelerate rapid granulation and regeneration of epidermis, supplement sufficient water to cell gap when exfoliating metabolic cutin, promote smooth skin with rough chapped skin, and improve absorption performance of skin against oxidation component.
The p-hydroxyacetophenone is a flavonoid substance existing in Gao Shanyun berries and most of Chinese medicinal herbs, has the effects of resisting oxidization and irritation, has the effects of resisting corrosion and enhancing synergy, and has no irritation. The invention adds a small amount of p-hydroxyacetophenone, which can synergistically improve the anti-aging performance of the anti-aging composition.
Tocopherol is an antioxidant, and a small amount of tocopherol is added in the invention, so that the anti-aging performance of the anti-aging composition can be synergistically improved.
Preferably, the anti-aging composition comprises the following components in weight percent:
0.2 to 0.4 percent of p-hydroxyacetophenone, 0.05 to 0.1 percent of allantoin, 0.10 to 0.25 percent of retinol, 0.05 to 0.1 percent of tocopherol, 40 to 60 percent of yeast extract, 0.5 to 1.5 percent of luffa root extract, 1.0 to 2.5 percent of calmYang compound plant sensitizer, 7.28 to 18.66 percent of other additives and the balance of water.
Further preferably, the anti-aging composition comprises the following components in parts by weight:
0.2% of p-hydroxyacetophenone, 0.05% of allantoin, 0.2% of retinol, 0.05% of tocopherol, 50% of yeast extract, 1.0% of luffa root extract, 2.0% of CalmYang compound plant desensitizer, 12.09% of other additives and the balance of water.
Within the above preferred range, the resulting anti-aging composition has a better anti-aging effect.
In order to further improve the effect of the anti-aging composition, to prolong the duration of the anti-oxidation effect, or to improve the storage stability of the anti-aging composition, other additives may be added as needed.
The other additives include, but are not limited to, at least one of moisturizers, preservatives, skin feel modifiers, fragrances, emulsifiers, chelating agents, or suspension stabilizers.
The humectant includes, but is not limited to, at least one of glycerin, 1, 2-hexanediol, sodium hyaluronate, betaine, saccharide isomers, or carrageenan (CHONDRUS CRISPUS) extract.
The skin feel modifier includes, but is not limited to, at least one of cyclopentadimethicone, dimethicone cross polymer, dimethicone, dimethiconol, or PEG-11 methyl ether dimethicone.
The preservative includes, but is not limited to, at least one of 1, 2-hexanediol, propylene glycol, octanoyl hydroxamic acid, or glycerol octanoate.
The emulsifier includes, but is not limited to, at least one of sodium acrylate-sodium acryloyldimethyl taurate copolymer, isohexadecane, polysorbate-80, or laurate.
The suspension stabilizers include, but are not limited to, xanthan gum.
The chelating agent includes, but is not limited to, disodium EDTA.
Conventional fragrances can be used in the present invention to impart a fragrance to the anti-aging composition as desired.
The invention also provides a preparation method of the anti-aging composition, which comprises the following steps:
mixing p-hydroxyacetophenone, allantoin, other additives and water at 82-85 ℃, adding mixed retinol and tocopherol, mixing uniformly, cooling to below 38 ℃, adding yeast extract, luffa root extract and calmsang compound plant sensitizer, and mixing uniformly to obtain the anti-aging composition.
Preferably, the mixing is at least one of stirring or homogenizing.
The anti-aging composition is a pale yellow paste, and has good storage stability within the range of-16 to 47 ℃.
The application of the anti-aging composition in preparing skin care products is also within the protection scope of the invention.
Optionally, the skin care product includes, but is not limited to, a mask, a toner, a serum, or a cream.
Compared with the prior art, the invention has the beneficial effects that:
the invention can energize cells to the metabolism of the stratum corneum through reasonable collocation among retinol, luffa root extract, yeast extract and calmYang compound plant anti-allergic agent, and can realize the anti-aging effect in different layers from inside to outside in an all-around way, so that the anti-aging effect is more remarkable. And the natural product extracts are adopted, and the skin care composition does not contain irritant antioxidant chemical substances and has mild effect on the skin.
Detailed Description
For a better description of the objects, technical solutions and advantages of the present invention, the present invention will be further described with reference to the following specific examples, which are not intended to limit the present invention in any way. Unless specifically stated otherwise, the reagents, methods and apparatus employed in the present invention are those conventional in the art. The reagents and materials used in the present invention are commercially available unless otherwise specified.
Example 1
The embodiment provides an anti-aging composition, which is prepared by a method comprising the following steps:
adding 35.51% of water, 0.2% of p-hydroxyacetophenone, 0.05% of allantoin and 12.09% of other additives into an emulsifying pot, heating to 82 ℃, uniformly stirring, adding 0.2% of retinol and 0.05% of tocopherol, uniformly stirring (about 10 min), cooling to 35 ℃, adding 50% of yeast extract, 1.0% of luffa root extract and 2.0% of calmYang compound plant sensitizer, and uniformly stirring to obtain the anti-aging composition.
Wherein, other additives consist of raw materials of 2 percent of glycerin, 0.5 percent of 1, 2-hexanediol, 0.4 percent of propylene glycol, 0.1 percent of xanthan gum, 0.05 percent of sodium hyaluronate, 1 percent of betaine, 0.02 percent of EDTA disodium, 1 percent of polydimethylsiloxane, 1 percent of cyclopenta-dimethicone, 1 percent of dimethiconol, 0.5 percent of PEG-11 methyl ether dimethicone, 1.5 percent of sodium acrylate-sodium acryloyldimethyl taurate copolymer, 2 percent of saccharide isomer and 1 percent of gomphrena.
Example 2
The embodiment provides an anti-aging composition, which is prepared by a method comprising the following steps:
adding 49.82% of water, 0.2% of p-hydroxyacetophenone, 0.05% of allantoin and 7.28% of other additives into an emulsifying pot, heating to 85 ℃, uniformly stirring, adding 0.10% of retinol and 0.05% of tocopherol, uniformly stirring (about 10 min), cooling to 30 ℃, adding 40% of yeast extract, 0.5% of luffa root extract and 1.0% of calmYang compound plant sensitizer, and uniformly stirring to obtain the anti-aging composition.
Wherein other additives comprise glycerin 1%,1, 2-hexanediol 0.3%, octanoyl hydroxamic acid 0.3%, xanthan gum 0.1%, sodium hyaluronate 0.05%, betaine 1%, EDTA disodium 0.02%, polydimethylsiloxane 0.5%, cyclopenta-dimethicone 0.5%, dimethiconol 0.3%, PEG-11 methyl ether dimethicone 0.4%, isohexadecane 0.8%, saccharide isomer 1%, chondrus crispus extract 1% and lavender essence 0.01%.
Example 3
The embodiment provides an anti-aging composition, which is prepared by a method comprising the following steps:
adding 16.52% of water, 0.4% of p-hydroxyacetophenone, 0.1% of allantoin and 18.63% of other additives into an emulsifying pot, heating to 85 ℃, uniformly stirring, adding 0.25% of retinol and 0.1% of tocopherol, uniformly stirring (about 10 min), cooling to 30 ℃, adding 60% of yeast extract, 1.5% of luffa root extract and 2.5% of calmYang compound plant sensitizer, and uniformly stirring to obtain the anti-aging composition.
Wherein other additives consist of raw materials of 2.5% of glycerin, 0.6% of 1, 2-hexanediol, 0.4% of octanoyl hydroxamic acid, 0.2% of xanthan gum, 0.1% of sodium hyaluronate, 2% of betaine, 0.03% of EDTA disodium, 2.0% of polydimethylsiloxane, 1.0% of cyclopentadimethicone, 2.0% of dimethiconol, 0.7% of PEG-11 methyl ether dimethicone, 1.6% of isohexadecane, 2.5% of saccharide isomers and 3% of a gomphrena extract.
Example 4
The embodiment provides an anti-aging composition, which is prepared by a method comprising the following steps:
adding 9.86% of water, 0.5% of p-hydroxyacetophenone and 0.2% of allantoin into an emulsifying pot, heating to 85 ℃, uniformly stirring, adding 1.0% of retinol and 0.3% of tocopherol, uniformly stirring (about 10 min), cooling to 30 ℃, adding 81.14% of yeast extract, 2.0% of luffa root extract and 5.0% of calmsang compound plant desensitizer, and uniformly stirring to obtain the anti-aging composition.
Comparative example 1
This comparative example provides an anti-aging composition prepared as in example 1, with the exception of example 1: no retinol was added and water was added to 100%.
Comparative example 2
This comparative example provides an anti-aging composition prepared as in example 1, with the exception of example 1: the yeast extract was not added and water was added to 100%.
Comparative example 3
This comparative example provides an anti-aging composition prepared as in example 1, with the exception of example 1: no extract of the luffa root is added, and water is added to 100%.
Comparative example 4
This comparative example provides an anti-aging composition prepared as in example 1, with the exception of example 1: no CalmYang compound plant sensitizer is added, and water is added to 100%.
Performance testing
The anti-aging compositions obtained in the above examples and comparative examples were tested for their properties:
performing wrinkle removing effect experiment, selecting 25 volunteers with wrinkles on eyes, uniformly applying the yellow pasty anti-aging composition prepared in the above examples and comparative examples on face with application amount of 2mg/cm 2 Facial data (in%) were collected using a VISA tester, and facial data before use, after 14 days of use and after 28 days of use of the sample were collected, respectively, and the results are shown in table 1, and are average values of the use effects of 25 volunteers in table 1.
Table 1 wrinkle-removing effect of anti-aging compositions obtained in examples and comparative examples
Note that: wrinkle change (%) =wrinkle index (%) -initial wrinkle index (%) after n days of use in table 1.
From the above results, it can be seen that:
the anti-aging composition prepared by the embodiment of the invention has good anti-wrinkling effect, namely good anti-aging performance, and all volunteers have no uncomfortable reactions such as allergy and the like.
The result of the comparative example further proves that the reasonable collocation among retinol, luffa root extract, yeast extract and calmsang compound plant sensitizer can enable cells to be energized to the metabolism of the stratum corneum, and the anti-aging effect is more remarkable in different layers and all directions from inside to outside.
Finally, it should be noted that the above embodiments are only for illustrating the technical solution of the present invention and not for limiting the scope of the present invention, and although the present invention has been described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that the technical solution of the present invention may be modified or substituted equally without departing from the spirit and scope of the technical solution of the present invention.
Claims (7)
1. An anti-aging composition, characterized by comprising the following components in percentage by weight:
0.2-0.5% of p-hydroxyacetophenone, 0.05-0.2% of allantoin, 0.05-1.0% of retinol, 0.05-0.3% of tocopherol, 1-99% of yeast extract, 0.1-2.0% of luffa root extract, 0.1-5% of calmYang compound plant sensitizer, 7.28-18.63% of other additives and the balance of water;
the calmYang compound plant anti-allergic agent consists of butanediol, water, centella asiatica (CENTELLA ASIATICA) extracts, polygonum cuspidatum (POLYGONUM CUSPIDATUM) root extracts, scutellaria baicalensis (SCUTELLARIA BAICALENSIS) root extracts, tea (CAMELLIA SINENSIS) leaf extracts, glycyrrhiza glabra (GLYCYRRHIZA GLABRA) root extracts, chamomile (CHAMOMILLA RECUTITA) flower extracts and rosemary (ROSMARINUS OFFICINALIS) leaf extracts;
the yeast extract is yeast fermentation lysate filtrate;
the other additives comprise at least one of moisturizer, preservative, skin feel modifier, essence, emulsifier, chelating agent or suspension stabilizer;
the humectant is at least one of glycerol, 1, 2-hexanediol, sodium hyaluronate, betaine, saccharide isomer or carrageenan extract; the skin feel modifier is at least one of cyclopentadimethicone, dimethicone cross polymer, dimethicone, dimethiconol or PEG-11 methyl ether dimethicone; the preservative is at least one of 1, 2-hexanediol, propylene glycol, octanoyl hydroxamic acid or glycerol caprylate; the emulsifier is at least one of sodium acrylate-sodium acryloyldimethyl taurate copolymer, isohexadecane, polysorbate-80 or laurinol laurate; the chelating agent is disodium EDTA; the suspension stabilizer is xanthan gum.
2. The anti-aging composition of claim 1, comprising the following components in weight percent:
0.2-0.4% of p-hydroxyacetophenone, 0.05-0.1% of allantoin, 0.10-0.25% of retinol, 0.05-0.1% of tocopherol, 40-60% of yeast extract, 0.5-1.5% of luffa root extract, 1.0-2.5% of calmYang compound plant sensitizer, 7.28-18.66% of other additives and the balance of water.
3. The anti-aging composition of claim 2, comprising the following components in weight percent:
0.2% of p-hydroxyacetophenone, 0.05% of allantoin, 0.2% of retinol, 0.05% of tocopherol, 50% of yeast extract, 1.0% of luffa root extract, 2.0% of CalmYang compound plant desensitizer, 12.09% of other additives and the balance of water.
4. A method of preparing an anti-aging composition according to any one of claims 1 to 3, comprising the steps of:
and uniformly mixing the p-hydroxyacetophenone, allantoin, other additives and water at 82-85 ℃, adding the mixed retinol and tocopherol, uniformly mixing, cooling to below 38 ℃, and then adding the yeast extract, the luffa root extract and the calmYang composite plant sensitizer, uniformly mixing, thereby obtaining the anti-aging composition.
5. The method of preparing an anti-aging composition according to claim 4, wherein the mixing is at least one of stirring or homogenizing.
6. Use of an anti-aging composition according to any one of claims 1 to 3 in the preparation of a skin care product.
7. The use of the anti-aging composition according to claim 6 for the preparation of a skin care product, wherein the skin care product is a mask, a toner, an essence or a cream.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210895828.2A CN115024991B (en) | 2022-07-27 | 2022-07-27 | Anti-aging composition and preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210895828.2A CN115024991B (en) | 2022-07-27 | 2022-07-27 | Anti-aging composition and preparation method and application thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN115024991A CN115024991A (en) | 2022-09-09 |
| CN115024991B true CN115024991B (en) | 2024-02-20 |
Family
ID=83130740
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210895828.2A Active CN115024991B (en) | 2022-07-27 | 2022-07-27 | Anti-aging composition and preparation method and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN115024991B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115778870A (en) * | 2022-11-30 | 2023-03-14 | 广州瑞誉化工科技有限公司 | Anti-wrinkle anti-aging composition and preparation method and application thereof |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105434274A (en) * | 2015-12-30 | 2016-03-30 | 天津嘉氏堂科技有限公司 | Towel gourd moisturizing lotion |
| CN108158910A (en) * | 2018-03-13 | 2018-06-15 | 艾因特丽（苏州）生物科技有限公司 | A kind of polypeptide compound formulation with senile-resistant efficacy and its preparation method and application |
| CN108220009A (en) * | 2016-12-13 | 2018-06-29 | 胡静波 | A kind of production method of sponge gourd craft medicated soap |
| CN109700753A (en) * | 2019-02-14 | 2019-05-03 | 成都市葆姿健康管理有限公司 | A kind of skin care compositions and its application and preparation method with moisturizing anti-oxidation efficacy |
| CN111840161A (en) * | 2020-08-11 | 2020-10-30 | 青岛瑞翰天成生物科技有限公司 | Anti-aging brightening composition and application and preparation method thereof |
| CN113398020A (en) * | 2021-05-28 | 2021-09-17 | 植物医生(广东)生物科技有限公司 | Composition with functions of refining pores and brightening skin color and application thereof |
| CN113693991A (en) * | 2021-09-24 | 2021-11-26 | 上海梦希生物科技有限公司 | Composition for effectively relieving wrinkle generation and preparation method and application thereof |
-
2022
- 2022-07-27 CN CN202210895828.2A patent/CN115024991B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105434274A (en) * | 2015-12-30 | 2016-03-30 | 天津嘉氏堂科技有限公司 | Towel gourd moisturizing lotion |
| CN108220009A (en) * | 2016-12-13 | 2018-06-29 | 胡静波 | A kind of production method of sponge gourd craft medicated soap |
| CN108158910A (en) * | 2018-03-13 | 2018-06-15 | 艾因特丽（苏州）生物科技有限公司 | A kind of polypeptide compound formulation with senile-resistant efficacy and its preparation method and application |
| CN109700753A (en) * | 2019-02-14 | 2019-05-03 | 成都市葆姿健康管理有限公司 | A kind of skin care compositions and its application and preparation method with moisturizing anti-oxidation efficacy |
| CN111840161A (en) * | 2020-08-11 | 2020-10-30 | 青岛瑞翰天成生物科技有限公司 | Anti-aging brightening composition and application and preparation method thereof |
| CN113398020A (en) * | 2021-05-28 | 2021-09-17 | 植物医生(广东)生物科技有限公司 | Composition with functions of refining pores and brightening skin color and application thereof |
| CN113693991A (en) * | 2021-09-24 | 2021-11-26 | 上海梦希生物科技有限公司 | Composition for effectively relieving wrinkle generation and preparation method and application thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN115024991A (en) | 2022-09-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN106511220A (en) | Dendrobium officinale moisturizing and repair sleeping mask and preparation method thereof | |
| CN108113914B (en) | Essence cream without essence and preservative and preparation method thereof | |
| CN103191042A (en) | Skin care agent capable of removing freckles, whitening, preventing wrinkles, moisturizing and resisting allergy and ageing | |
| CN111166683A (en) | Fullerene anti-aging antioxidant beauty and skin care cosmetic and preparation method thereof | |
| CN104971029A (en) | Whitening mask and preparation method thereof | |
| CN102293733A (en) | Overall whitening and speckle removal skin care product | |
| CN104958240A (en) | Freckle expelling facial mask and preparation method thereof | |
| CN109674724B (en) | A kind of sleep mask and preparation method thereof containing dendrobium nobile | |
| CN106727148A (en) | Facial mask and preparation method thereof is repaired in a kind of dendrobium candidum moisturizing | |
| CN110638707A (en) | Eye care cream and preparation method thereof | |
| GB2451224A (en) | Cosmetic composition comprising an exfoliant, astringent, antioxidant and moisturiser | |
| CN107638331A (en) | A kind of maintenance skin barrier and the moisturizing emulsion for resisting free radical | |
| CN109998937B (en) | Cosmetic series containing glycerol glucoside (alpha GG) and preparation method thereof | |
| CN106551868A (en) | A kind of resveratrol multi-effect compound facial film and preparation method thereof | |
| CN104983647A (en) | Deep restoration mask and making method thereof | |
| CN104434707A (en) | Whitening and freckle-removing essence | |
| CN111450010A (en) | Composition with anti-aging effect and application thereof in cosmetics | |
| CN104983646A (en) | Night maintenance mask solution and preparation method thereof | |
| CN110960458A (en) | Moisturizing essence emulsion and preparation method thereof | |
| CN104958242A (en) | Anti-ultraviolet mask liquid and preparation method thereof | |
| CN111973508A (en) | Anti-aging composition capable of relieving and moisturizing | |
| CN112006958A (en) | Depilatory cream and preparation method thereof | |
| KR102071627B1 (en) | Peeling gel composition for removing keratin of skin and manufacturing method thereof | |
| CN115024991B (en) | Anti-aging composition and preparation method and application thereof | |
| CN104490713A (en) | Super-soft living spring skin care product with functions of removing foul, tightening, resisting wrinkles and activating skin |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |