CN113398020A - Composition with functions of refining pores and brightening skin color and application thereof - Google Patents

Composition with functions of refining pores and brightening skin color and application thereof Download PDF

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CN113398020A
CN113398020A CN202110593112.2A CN202110593112A CN113398020A CN 113398020 A CN113398020 A CN 113398020A CN 202110593112 A CN202110593112 A CN 202110593112A CN 113398020 A CN113398020 A CN 113398020A
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skin
extract
parts
composition
refining
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CN113398020B (en
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林霁
郭文姣
孙美娟
刘裕娇
贺锐
谢勇
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Plant Doctor Guangdong Biotechnology Co ltd
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Plant Doctor Guangdong Biotechnology Co ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/41Amines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67Vitamins
    • A61K8/678Tocopherol, i.e. vitamin E
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9728Fungi, e.g. yeasts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59Mixtures
    • A61K2800/592Mixtures of compounds complementing their respective functions
    • A61K2800/5922At least two compounds being classified in the same subclass of A61K8/18

Abstract

The invention discloses a composition with functions of refining pores and brightening skin color and application thereof, and belongs to the technical field of skin care products. The composition comprises the following components in parts by weight: 0.01-0.2 part of salicyloyl phytosphingosine, 0.01-0.5 part of tocopherol, 0.1-5 parts of yeast lysate and 0.5-8 parts of plant extract, wherein the plant extract is Rosa canina fruit extract and yarrow extract. The elasticity of skin is increased through the deposition of salicyloyl phytosphingosine on protein, the metabolism activity of cells is enhanced through yeast lysate, the facial skin is finer and smoother and glossy, the effects of pore refining and skin color brightening are achieved, the rosa canina fruit extract and the achillea millefolium extract are in synergistic system action, the skin oil secretion can be effectively balanced, the skin roughness is reduced, the skin texture is improved, the skin glossiness is increased, the pores can be further effectively refined, and the skin is brightened.

Description

Composition with functions of refining pores and brightening skin color and application thereof
Technical Field
The invention relates to the technical field of skin care products, in particular to a composition with functions of refining pores and brightening skin color and application thereof.
Background
With the development of society and the improvement of the quality of life of people, the attention of people to facial skin rises year by year, and with the increase of age, the problems of large pores, dark complexion and the like of the facial skin occur. The large pores are related to factors such as vigorous grease secretion in adolescence, pore blockage, improper skin care and repair, skin elasticity reduction, photoaging, environmental pollution and the like. At present, most of products sold in the market adopt pore-refining skin care products containing salicylic acid, lactobionic acid, glycolic acid and other components, which can soften cutin, remove accumulated keratotic plug and promote epidermis renewal, but because the pH value of the products is lower, the products have greater irritation to the skin and are easy to cause damage to sensitive skin. The skin care products for brightening the skin color sold in the market at present have little effect of refining pores. Most of the traditional Chinese medicine composition is added with ingredients such as phenethyl resorcinol and VA derivatives, so that the traditional Chinese medicine composition has some irritation to skin, and part of people need a tolerance period to adapt. Therefore, a mild and non-irritating skin care product with the effects of refining pores and brightening skin color is lacked.
CN109288781A discloses a whitening and skin-tendering essence emulsion with skin color brightening effect and a preparation method thereof, wherein the whitening and skin-tendering essence emulsion comprises the following components in percentage by weight: 0.01-3% of papaya oil, 0.01-3% of sea buckthorn fruit oil, 0.01-3% of plum kernel oil, 0.01-2% of magnolia alba essential oil, 0.01-3% of seaweed extract, 0.01-3% of water lily extract, 0.01-3% of oriental cherry extract, 0.01-3% of mulberry extract, 0.01-1% of peony root extract, 0.01-1% of apple root extract, 0.01-3% of red ball ginger extract, 0.01-3% of palm tree extract, 0.01-3% of garden burnet extract, 0.5-3% of pearl hydrolysate, 0.01-3% of retinol palmitate, 0.01-1% of 3-O-ethyl ascorbic acid, 0.01-2% of salicyloyl phytosphingosine, 0.01-2% of beta-phenacetate, 0.5-5% of cocoyl ethyl glucoside, 0.5-5% of synthetic poloxamer, 0.1-3% of squalane, 0.01-2% of D-panthenol, 0.01-2% of tocopherol, 0.5-2% of squalene, 0.5-5% of sodium alginate, 0.5-5% of fucoidin, 5-3% of fucoidin, 0.1-4% of carbomer, 1-20% of glycerol and the balance of deionized water. The skin care product mainly realizes the effects of moisturizing and tendering the skin through the synergistic effect of the effective active ingredients of various plants, and does not aim at improving and brightening the pore refining effect of the skin care product.
Disclosure of Invention
The invention aims to solve the technical problem of overcoming the defect and the defect that the existing whitening and skin-tendering skin care products cannot simultaneously have good effects of brightening skin and refining pores, and provides a composition with the functions of refining pores and brightening skin.
Still another object of the present invention is to provide a skin care product containing a composition having the functions of pore refining and skin color brightening.
It is yet another object of the present invention to provide a skin care article.
It is yet another object of the present invention to provide a method of making a skin care article.
The above purpose of the invention is realized by the following technical scheme:
a composition with the functions of refining pores and brightening skin color comprises the following components in parts by weight: 0.01-0.2 part of salicyloyl phytosphingosine, 0.01-0.5 part of tocopherol, 0.1-5 parts of yeast lysate and 0.5-8 parts of plant extract, wherein the plant extract is Rosa canina fruit extract and yarrow extract.
Among the factors affecting the large pores, the sebaceous gland secretion is positively correlated with the size of the pores, the inner sides of the nose and the cheek are the areas with the most vigorous sebaceous gland secretion, and the large pores on the inner sides of the nose and the cheek are usually more obvious than the outer sides of the cheek, showing the close relationship between the vigorous sebaceous gland secretion and the large pores. On the other hand, skin elasticity and tensile strength are inversely related to facial pore size and density. Skin aging and chronic photodamage cause thinning of the epidermis, reduction of collagen fibers, disorganization of elastic fibers, reduction of skin elasticity, and loosening of pores due to loss of support of collagen fibers, which is manifested by a coarse appearance of pores.
The salicyloyl phytosphingosine has the beneficial effects of salicylic acid and phytosphingosine on skin, and can influence the expression level of fibroblasts in skin, so that the collagen I is remarkably increased. The matrix metalloproteinase 1 can promote the degradation of collagen in the skin aging process, so that the skin loses elasticity, and the salicyloyl phytosphingosine can increase the deposition of fibrin and collagen I and is beneficial to inhibiting the increase of the matrix metalloproteinase 1, so that the elasticity and thickness of the skin are increased and pores are refined.
The appearance of skin photoaging is also manifested by a large number of pores and dark skin tone. The photodamage is caused by that a large number of active oxygen clusters are generated in the skin after illumination, an antioxidant system in the skin is consumed and comprises antioxidant enzyme and low-molecular antioxidant, so that lipid and protein are oxidized, DNA is damaged, metalloenzyme is activated, and the like, so that the skin is subjected to a series of changes, and tocopherol serving as a natural antioxidant plays a good role in protecting the skin from photodamage and preventing the progression of photoaging by eliminating the active oxygen clusters, so that large pores and dark skin color caused by the photoaging can be avoided.
The yeast lysate can be used in vitro to enhance the metabolism activity of cells, and the addition of the yeast lysate can make the facial skin finer and smoother, so that the effects of refining pores and brightening skin color are achieved.
The combination of Rosa canina fruit extract and Achillea millefolium extract has synergistic effect, and can balance skin oil secretion and reduce pachylosis, improve skin texture, and increase skin glossiness. Because sebaceous gland secretion is positively correlated with pore size, the synergistic effect of Rosa canina fruit extract and Achillea millefolium extract can further effectively refine pores and brighten skin.
Among them, it should be noted that:
the yarrow extract is preferably prepared by extracting yarrow from areas such as Xinjiang, inner Mongolia and the like with the average altitude of more than 1000 meters, and the areas have the advantages of large temperature difference, strong sunlight, less pollution and higher active matter content of the yarrow, wherein the yarrow extract mainly contains compounds such as flavonoid, terpenes, lignans, steroids and the like, has remarkable effects of resisting bacteria, diminishing inflammation, detoxifying and relieving pain and the like, can be used for synergistically improving skin inflammation with the rosa canina fruit extract, preventing pores from being inflamed and blocked, and dredging pores, and better balancing skin oil secretion.
The composition does not contain ingredients such as phenethyl resorcinol and VA derivatives which are common in the existing skin care products, has neutral to weak acid pH value, is mild to skin, and avoids irritation caused by too low pH value of the product.
Preferably, the composition comprises, by weight, 0.05-0.2 parts of salicyloyl phytosphingosine, 0.02-0.2 parts of tocopherol, 0.1-5 parts of yeast lysate and 2.5-8 parts of plant extract.
Further preferably, the composition comprises, by weight, 0.1-0.2 parts of salicyloyl phytosphingosine, 0.05-0.2 parts of tocopherol, 0.1-5 parts of yeast lysate and 2.5-8 parts of plant extract.
Further preferably, the composition comprises, by weight, 0.15-0.2 parts of salicyloyl phytosphingosine, 0.05-0.2 parts of tocopherol, 5 parts of yeast lysate and 4.5-8 parts of plant extract.
Preferably, the mass ratio of the Rosa canina fruit extract to the yarrow extract in the plant extract is 1: 0.5-1: 2.
For example, it may be:
the mass ratio of the Rosa canina fruit extract to the yarrow extract in the plant extract is 1: 1;
the mass ratio of the Rosa canina fruit extract to the yarrow extract in the plant extract is 1: 1.25;
the mass ratio of the Rosa canina fruit extract to the yarrow extract in the plant extract is 1: 0.8;
the mass ratio of the Rosa canina fruit extract to the yarrow extract in the plant extract is 1: 1.5;
the mass ratio of Rosa canina fruit extract to Achillea millefolium extract in the plant extract is 1: 2.
Preferably, the mass ratio of the Rosa canina fruit extract to the yarrow extract in the plant extract is 1: 1.25-1.5.
Preferably, the yarrow extract contains flavonoids, terpenoids, lignans and steroids.
Preferably, the strain used by the yeast lysate is a saccharomyces cerevisiae strain, the strain has high renewability and contains polypeptide, amino acid, carbohydrate, nucleic acid and other metabolism, and the content of the functional components of the yeast lysate prepared by purification after biological fermentation is higher.
Preferably, the yeast lysate comprises threonine, glycine, valine, glutamic acid, and disodium succinate.
The yeast lysate is prepared by adopting a special beer yeast (Saccharomyces cerevisiae) strain and performing a series of purification processes after fermentation by adopting biotechnology, and is rich in active ingredients such as threonine, glycine, valine, glutamic acid, disodium succinate and the like. Threonine is an essential amino acid for human bodies, glycine is helpful for resisting inflammation and protecting cells, valine is helpful for repairing damaged tissues, glutamic acid is helpful for improving the oxidation resistance and detoxifying and purifying, and disodium succinate is helpful for enhancing the production of bioenergy by mitochondria and promoting cell metabolism.
The application of the composition with the functions of pore refining and skin color brightening in the preparation of skin care products is also within the protection scope of the invention.
In the skin care product applied by the skin care product, the invention also specifically protects the skin care product which comprises the following components in parts by mass:
the component A comprises: 70-90 parts of water, 0.01-0.2 part of sodium hyaluronate, 0.5-10 parts of humectant, 0.01-0.1 part of chelating agent, 0.1-1 part of thickening agent, 0.01-0.2 part of salicyloyl phytosphingosine and 0.05-1 part of absolute ethyl alcohol;
and B component: 0.01-0.5 part of tocopherol, 0.1-5 parts of yeast lysate, and 0.5-8 parts of Rosa canina fruit extract and yarrow extract, wherein the ratio of the Rosa canina fruit extract to the yarrow extract is 1: 0.5-2;
and C, component C: 0.1-1 part of preservative;
and (D) component: 0.5-5 parts of anti-allergy relieving component.
Among them, it should be noted that:
the humectant includes one or more of glycerol, propylene glycol, butanediol, pentanediol, erythritol, trehalose, hydroxyethyl urea, and glyceryl polyether-26;
chelating agents include disodium EDTA;
the thickening agent comprises one or more of carbomer, acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer, acrylic acid (ester) copolymer sodium, polyacrylate cross-linked polymer-6, acryloyl dimethyl taurate/VP copolymer and poly acryloyl dimethyl taurate;
the antiseptic comprises one or more of phenoxyethanol, ethylhexyl glycerol, hexanediol, methyl hydroxybenzoate, p-hydroxyacetophenone, and glyceryl caprylate;
the anti-allergy and soothing component comprises one or more of dextran, Tremella extract, caulis Opuntiae Dillenii extract, hydrogenated phosphatidylcholine, and allantoin.
The skin care preparation described above can be prepared by suitable methods known in the art. The invention also specifically provides a preparation method of the composition with the functions of refining pores and brightening skin color, which comprises the following steps:
1) cleaning and disinfecting production equipment;
2) pre-dissolving the component A, namely salicyloyl phytosphingosine, in absolute ethanol with the volume ratio of 1: 2-1: 5, adding the obtained solution into a main pot, stirring, and properly heating to 60-80 ℃ to completely dissolve the obtained product;
3) and (3) cooling the temperature of the main boiler to 35-40 ℃, and uniformly stirring the main boilers in the group B.
4) Adding the component C and the component D into a main pot, uniformly stirring at 35-40 ℃, checking the pH value to be 5.5-7.3, and filtering and discharging.
Compared with the prior art, the invention has the beneficial effects that:
the invention provides a composition with functions of pore refining and skin color brightening, deposition of fibrin and collagen I is increased through salicyloyl phytosphingosine, skin elasticity is increased, pore refining is facilitated, metabolism activity of cells is enhanced through yeast lysate, facial skin is enabled to be finer and smoother and shinier, the effects of pore refining and skin color brightening are achieved, and the rosa canina fruit extract and the achillea millefolium extract are in synergistic system effect, so that skin oil secretion can be effectively balanced, skin roughness is reduced, skin texture is improved, skin glossiness is increased, pores can be further effectively refined, and skin is brightened.
When the composition is applied to a skin care product, the improvement rate of 6W pore number can reach 10%, the improvement rate of pore area can reach 16%, and the composition has a remarkable pore refining effect; the improvement rate of the skin glossiness 6W can reach 106%, the improvement rate of the skin whiteness 6W can reach 2%, the improvement rate of the skin brightness 6W can reach 7%, and the skin whitening and brightening agent has the effects of further thinning textures and brightening skin colors.
Drawings
Fig. 1 is a high-definition photograph of the face of subject 1 taken by VISIA-CR.
Fig. 2 is a high-definition photograph of the face of subject 2 taken by VISIA-CR.
Detailed Description
The present invention will be further described with reference to specific embodiments, but the present invention is not limited to the examples in any way. The starting reagents employed in the examples of the present invention are, unless otherwise specified, those that are conventionally purchased.
Example 1
A skin care article comprising phase a, phase B, phase C, and phase D, wherein the amounts of each phase are as set forth in table 1 below:
TABLE 1
Figure BDA0003089957540000061
Wherein the content of the first and second substances,
the humectant is as follows: glycerol;
the chelating agent is: disodium EDTA;
the thickening agent is: carbomer;
the preservative is as follows: phenoxyethanol;
the plant extract is a mixture of Rosa canina fruit extract and Achillea millefolium extract at a mass ratio of 1: 1;
the anti-allergy and soothing components comprise Tremella extract and allantoin.
The yeast lysate is prepared by purifying and purifying the beer yeast strain after biological fermentation, and contains threonine, glycine, valine, glutamic acid and disodium succinate.
The extract of Achillea millefolium contains flavonoids, terpenoids, lignans and steroids
The preparation method of the skin care product comprises the following steps:
1) cleaning and disinfecting production equipment;
2) adding the component A into a main pot, stirring, and properly heating to 60-80 ℃ to completely dissolve;
3) and (3) cooling the temperature of the main pot to 35-40 ℃, adding the component B into the main pot, and uniformly stirring.
4) And adding the component C and the component D into a main pot, uniformly stirring, inspecting, and filtering and discharging after the pH value is 5.5-7.3.
Example 2
A skin care article comprising phase a, phase B, phase C, and phase D, wherein the amounts of each phase are as set forth in table 2 below:
TABLE 2
Figure BDA0003089957540000071
Wherein the content of the first and second substances,
the humectant is as follows: glycerol;
the chelating agent is: disodium EDTA;
the thickening agent is: carbomer;
the preservative is as follows: phenoxyethanol;
the plant extract is a mixture of Rosa canina fruit extract and Achillea millefolium extract at a mass ratio of 1: 1.25;
the anti-allergy and soothing components comprise Tremella extract and allantoin.
The yeast lysate is prepared by purifying and purifying the beer yeast strain after biological fermentation, and contains threonine, glycine, valine, glutamic acid and disodium succinate.
The extract of Achillea millefolium contains flavonoids, terpenoids, lignans and steroids
The specific skin care preparation was prepared as in example 1.
Example 3
A skin care article comprising phase a, phase B, phase C, and phase D, wherein the amounts of each phase are as set forth in table 3 below:
TABLE 3
Figure BDA0003089957540000081
Wherein the content of the first and second substances,
the humectant is as follows: glycerol;
the chelating agent is: disodium EDTA;
the thickening agent is: carbomer;
the preservative is as follows: phenoxyethanol;
the plant extract is a mixture of Rosa canina fruit extract and Achillea millefolium extract at a mass ratio of 1: 0.8;
the anti-allergy and soothing components comprise Tremella extract and allantoin.
The yeast lysate is prepared by purifying and purifying the beer yeast strain after biological fermentation, and contains threonine, glycine, valine, glutamic acid and disodium succinate.
The extract of Achillea millefolium contains flavonoids, terpenoids, lignans and steroids
The specific skin care preparation was prepared as in example 1.
Example 4
A skin care article comprising phase a, phase B, phase C, and phase D, wherein the amounts of each phase are as set forth in table 4 below:
TABLE 4
Figure BDA0003089957540000091
Wherein the content of the first and second substances,
the humectant is as follows: glycerol;
the chelating agent is: disodium EDTA;
the thickening agent is: carbomer;
the preservative is as follows: phenoxyethanol;
the plant extract is a mixture of Rosa canina fruit extract and Achillea millefolium extract at a mass ratio of 1: 1.5;
the anti-allergy and soothing components comprise Tremella extract and allantoin.
The yeast lysate is prepared by purifying and purifying the beer yeast strain after biological fermentation, and contains threonine, glycine, valine, glutamic acid and disodium succinate.
The extract of Achillea millefolium contains flavonoids, terpenoids, lignans and steroids
The specific skin care preparation was prepared as in example 1.
Example 5
A skin care article comprising phase a, phase B, phase C, and phase D, wherein the amounts of each phase are as set forth in table 5 below:
TABLE 5
Figure BDA0003089957540000101
Wherein the content of the first and second substances,
the humectant is as follows: glycerol;
the chelating agent is: disodium EDTA;
the thickening agent is: carbomer;
the preservative is as follows: phenoxyethanol;
the plant extract is a mixture of Rosa canina fruit extract and Achillea millefolium extract at a mass ratio of 1: 2;
the anti-allergy and soothing components comprise Tremella extract and allantoin.
The yeast lysate is prepared by purifying and purifying the beer yeast strain after biological fermentation, and contains threonine, glycine, valine, glutamic acid and disodium succinate.
The extract of Achillea millefolium contains flavonoids, terpenoids, lignans and steroids
The specific skin care preparation was prepared as in example 1.
Comparative example 1
A skin care article comprising phase a, phase B, phase C, and phase D, wherein the amounts of each phase are as set forth in table 6 below:
TABLE 6
Figure BDA0003089957540000111
Wherein the content of the first and second substances,
the humectant is as follows: glycerol;
the chelating agent is: disodium EDTA;
the thickening agent is: carbomer;
the preservative is as follows: phenoxyethanol;
the anti-allergy and soothing components comprise Tremella extract and allantoin.
The yeast lysate is prepared by purifying and purifying the beer yeast strain after biological fermentation, and contains threonine, glycine, valine, glutamic acid and disodium succinate.
The extract of Achillea millefolium contains flavonoids, terpenoids, lignans and steroids
The specific skin care preparation was prepared as in example 1.
Comparative example 2
A skin care article comprising phase a, phase B, phase C, and phase D, wherein the amounts of each phase are as set forth in table 7 below:
TABLE 7
Figure BDA0003089957540000121
Wherein the content of the first and second substances,
the humectant is as follows: glycerol;
the chelating agent is: disodium EDTA;
the thickening agent is: carbomer;
the preservative is as follows: phenoxyethanol;
the plant extract is a mixture of Rosa canina fruit extract and Achillea millefolium extract at a mass ratio of 1: 1;
the anti-allergy and soothing components comprise Tremella extract and allantoin.
The extract of Achillea millefolium contains flavonoids, terpenoids, lignans and steroids
The specific skin care preparation was prepared as in example 1.
Comparative example 3
A skin care article comprising phase a, phase B, phase C, and phase D, wherein the amounts of each phase are as set forth in table 8 below:
TABLE 8
Figure BDA0003089957540000131
Wherein the content of the first and second substances,
the humectant is as follows: glycerol;
the chelating agent is: disodium EDTA;
the thickening agent is: carbomer;
the preservative is as follows: phenoxyethanol;
the plant extract is a mixture of Rosa canina fruit extract and Achillea millefolium extract at a mass ratio of 1: 1;
the anti-allergy and soothing components comprise Tremella extract and allantoin.
The yeast lysate is prepared by purifying and purifying the beer yeast strain after biological fermentation, and contains threonine, glycine, valine, glutamic acid and disodium succinate.
The extract of Achillea millefolium contains flavonoids, terpenoids, lignans and steroids
The specific skin care preparation was prepared as in example 1.
Result detection
(1) Effective in refining pores
The specific detection method comprises the following steps:
56 volunteers were recruited by an objective instrument evaluation method, the age was 18-60 years, the test was performed by a double-blind method, the test period was 6 weeks, the skin data acquisition times were 3 times, 0W, 4W, and 6W, respectively. And (4) screening qualified subjects according to requirements, signing the volunteer informed consent with the qualified subjects when the volunteer visits for the first time, collecting 0-week data and issuing samples. The number of pores and the ratio of pore area are analyzed by Image analysis software Image Pro Plus at the visit of 2 nd and 3 rd volunteers.
Wherein the pore-refining effect is shown in the following tables 9 and 10:
TABLE 9 number of pores measurement results
Item 0W 4W 6W 4W improvement (%) 6W improvement (%)
Example 1 596 580 571 2.68 4.19
Example 2 430 396 387 7.91 10.00
Example 3 383 361 365 5.74 4.70
Example 4 795 759 754 4.53 5.16
Example 5 556 530 541 4.68 2.70
Comparative example 1 460 450 451 2.17 1.96
Comparative example 2 581 579 608 0.34 -4.65
Comparative example 3 645 641 640 0.62 0.78
TABLE 10 measurement of pore area fraction
Item 0W 4W 6W 4W improvement (%) 6W improvement (%)
Example 1 0.0629 0.0587 0.0579 6.68 7.95
Example 2 0.0833 0.0755 0.0697 9.36 16.33
Example 3 0.0847 0.0803 0.0776 5.19 8.38
Example 4 0.0716 0.0679 0.0643 5.17 10.20
Example 5 0.0708 0.0683 0.0657 3.53 7.20
Comparative example 1 0.0813 0.0796 0.0821 2.09 -0.98
Comparative example 2 0.0824 0.0825 0.0876 -0.12 -6.31
Comparative example 3 0.0776 0.0782 0.0779 -0.77 -0.39
The data in tables 9 and 10 show that, when the composition with the functions of refining pores and brightening skin color of the present invention is applied to a skin care product, the composition can achieve a good effect of reducing the number of pores and the proportion of pore area in a 4W skin renewal cycle, and has a significant pore refining effect, and the effect is significantly higher than the corresponding proportional pore refining effect. The composition has good pore refining effect after being used for 6W, and shows that the composition with the functions of refining pores and brightening skin color not only has quick response, but also has long-acting effect.
(2) The effect of brightening skin color
The volunteers collected skin images, skin glossiness GLOSS DSC, skin whiteness L x value and skin ITA DEG value at the 2 nd visit and the 3 rd visit, thereby embodying the skin brightening efficacy of the volunteers.
The specific test results are shown in tables 11 to 13 below.
TABLE 11 skin gloss measurement results
Item 0W 4W 6W 4W improvement (%) 6W improvement (%)
Example 1 8.734 12.576 13.576 43.99 55.44
Example 2 4.561 7.739 9.387 69.67 105.80
Example 3 5.882 9.628 9.198 63.69 56.38
Example 4 5.449 8.167 9.214 49.88 69.10
Example 5 4.897 6.173 7.173 26.06 46.48
Comparative example 1 4.198 4.207 4.367 0.20 4.01
Comparative example 2 7.474 7.793 7.893 4.26 5.59
Comparative example 3 4.560 4.816 4.862 5.62 6.61
TABLE 12 measurement of skin whiteness L
Item 0W 4W 6W 4W improvement (%) 6W improvement (%)
Example 1 85.740 85.721 86.965 -0.02 1.43
Example 2 83.106 84.229 84.783 1.35 2.02
Example 3 83.066 83.307 84.270 0.29 1.45
Example 4 82.757 83.273 83.989 0.62 1.49
Example 5 82.803 83.132 83.920 0.40 1.35
Comparative example 1 85.192 84.728 85.373 -0.55 0.21
Comparative example 2 84.853 83.554 84.760 -1.53 -0.11
Comparative example 3 86.162 85.594 85.884 -0.66 -0.32
TABLE 13 skin Brightness ITA DEG value test results
Figure BDA0003089957540000151
Figure BDA0003089957540000161
From the above data, it is clear that the number of pores and the ratio of pore area of the facial skin of the subject are improved, the skin glossiness is greatly improved, and the skin whiteness and the skin brightness are also improved after the composition is used. Therefore, the composition has the effects of obviously tightening and shrinking pores and improving the whiteness, glossiness and fineness of skin.
(3) Use assessment
Meanwhile, the volunteers subjectively evaluate the improvement condition of the skin after the product is used in the embodiment, and score the facial pore significance and the skin fineness before and after the product is used according to a 0-10-point scoring standard. The higher the score, the less visible the pores and the more delicate the skin.
Figure BDA0003089957540000162
Note: "*": p <0.05, indicating poor significance, "×": p <0.01, indicating a very significant difference.
After 2 subjects took high-definition photographs of their faces taken by VISIA-CR, the results of comparing their improvement in their facial skin before application of the sample (week 0) with that after application of the sample for 6 weeks (self-contrast) are shown in fig. 1 and 2, and it can be seen from the figures that the skin of the subjects' faces were whiter than before application, the skin was smoother and more delicate, the pores were less visible, and the skin appeared more shiny and beautiful.
It should be understood that the above-described embodiments of the present invention are merely examples for clearly illustrating the present invention, and are not intended to limit the embodiments of the present invention. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. And are neither required nor exhaustive of all embodiments. Any modification, equivalent replacement, and improvement made within the spirit and principle of the present invention should be included in the protection scope of the claims of the present invention.

Claims (10)

1. The composition with the functions of refining pores and brightening skin color is characterized by comprising the following components in parts by weight: 0.01-0.2 part of salicyloyl phytosphingosine, 0.01-0.5 part of tocopherol, 0.1-5 parts of yeast lysate and 0.5-8 parts of plant extract, wherein the plant extract is Rosa canina fruit extract and yarrow extract.
2. The composition with the functions of refining pores and brightening skin color according to claim 1, characterized in that, by weight, the salicyloyl phytosphingosine is 0.15-0.2 parts, the tocopherol is 0.05-0.2 parts, the yeast lysate is 1-4 parts, and the plant extract is 4.5-6 parts.
3. The composition having the functions of pore-refining and skin color-lightening as claimed in claim 1, wherein the mass ratio of the rosa canina fruit extract to the yarrow extract in the plant extract is 1:0.5 to 1: 2.
4. The composition having the functions of pore refining and skin color brightening according to claim 3, wherein the mass ratio of the rosa canina fruit extract to the yarrow extract in the plant extract is 1: 1.25-1.5.
5. The composition for pore-refining and skin color-lightening as claimed in claim 1, wherein the extract of yarrow comprises flavonoids, terpenoids, lignans and steroids.
6. The composition for pore refining and skin color enhancement according to claim 1, wherein the yeast lysate is prepared by purifying a saccharomyces cerevisiae strain after biological fermentation.
7. The composition for pore refining and skin color enhancement according to claim 6, wherein the yeast lysate comprises threonine, glycine, valine, glutamic acid, and disodium succinate.
8. Use of the composition for pore refining and skin color enhancement according to any one of claims 1 to 7 in the preparation of a skin care product.
9. The skin care product is characterized by comprising the following components in parts by mass:
the component A comprises: 70-90 parts of water, 0.01-0.2 part of sodium hyaluronate, 0.5-10 parts of humectant, 0.01-0.1 part of chelating agent, 0.1-1 part of thickening agent, 0.01-0.2 part of salicyloyl phytosphingosine and 0.05-1 part of absolute ethyl alcohol;
and B component: 0.01-0.5 part of tocopherol, 0.1-5 parts of yeast lysate, and 0.5-8 parts of Rosa canina fruit extract and yarrow extract, wherein the ratio of the Rosa canina fruit extract to the yarrow extract is 1: 0.5-2;
and C, component C: 0.1-1 part of preservative.
And (D) component: 0.5-5 parts of anti-allergy relieving component.
10. The preparation method of the skin care product according to claim 9, wherein the skin care product is prepared by pre-dissolving salicyloyl phytosphingosine in absolute ethanol with a volume ratio of 1:2 to 1:5, heating to 60 to 80 ℃, adding the component A, homogenizing, adding the component B, the component C and the component D at a temperature of 35 to 40 ℃ and under a pH condition of 5.5 to 7.3, and uniformly mixing.
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