CN116350552B - A facial cream with effects of relieving and resisting aging, and its preparation method - Google Patents

A facial cream with effects of relieving and resisting aging, and its preparation method Download PDF

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CN116350552B
CN116350552B CN202310024717.9A CN202310024717A CN116350552B CN 116350552 B CN116350552 B CN 116350552B CN 202310024717 A CN202310024717 A CN 202310024717A CN 116350552 B CN116350552 B CN 116350552B
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cream
extract
sodium
soothing
lysine
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CN116350552A (en
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招敏聪
田佳佳
郑倩楠
贺锐
解勇
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Plant Doctor Guangdong Biotechnology Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/592—Mixtures of compounds complementing their respective functions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/592—Mixtures of compounds complementing their respective functions
    • A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Gerontology & Geriatric Medicine (AREA)
  • Dermatology (AREA)
  • Cosmetics (AREA)

Abstract

The invention relates to the technical field of cosmetics, in particular to a soothing and anti-aging facial cream and a preparation method thereof. The cream comprises polyglycerol-3-methylglucdistearate, sodium di (lauramide glutamine) lysine, fructus Canarii albi extract, herba Canarii albi extract, fructus Rosae Davuricae extract, and radix et caulis Opuntiae Dillenii stem extract. The face cream has excellent moisturizing, antioxidation, anti-aging, soothing and anti-irritation performances. The cream reduced the amount of sample required to reduce the DPPH removal percentage to 50% to 0.29g/mL. The cream produced 50% erythrocyte hemolysis requiring a concentration HD50 as high as 24296mg/L and a protein denaturation index DI as low as 0.70%.

Description

A facial cream with effects of relieving and resisting aging, and its preparation method
Technical Field
The invention relates to the technical field of cosmetics, in particular to a soothing and anti-aging facial cream and a preparation method thereof.
Background
With age, the skin has a lower and lower shrink ability, resulting in a dark yellow and matt face, wrinkles, etc. The cream is a relatively thick paste skin care product, has good skin moisturizing effect and moisture preserving effect, and is particularly suitable for being used in autumn and winter.
The cosmetic is used for a long time while people pursue beauty, and the long-term use of the cosmetic can lead the skin to be more sensitive easily due to different factors, such as the quality of the cosmetic, the change of skin health degree or the environment, and the like, so that the requirements on the comfort of the cosmetic and the reduction of skin irritation are higher and higher. Meanwhile, anti-aging is also an important assessment performance of the cosmetics by users.
Therefore, there is a need to provide a soothing, anti-aging cream to solve the problem of further imparting soothing, anti-irritation to the cream on the basis of the need to provide the most basic anti-aging properties.
Disclosure of Invention
The invention aims to provide a soothing and anti-aging facial cream, which solves the problems that the existing facial cream needs to provide the most basic anti-aging performance and needs to endow the facial cream with anti-irritation performance.
The invention provides a soothing and anti-aging facial cream, which uses a plant extract, namely a Fabricius elemi (TERMINALIA FERDINANDIANA) fruit extract, a coastal thorn celery (ERYNGIUM MARITIMUM) extract, a Rosa canina fruit extract (Rosa Canina Fruit Extract) and a Cactus acula (OPUNTIA STREPTACANTHA) stem extract; wherein, the compound of the falcate elemene fruit extract and the coastal cress extract has excellent effects in giving anti-aging effects to the face cream and the like, and the compound of the dog rose fruit extract and the Cactus stem extract has remarkable effects in giving the face cream to be relaxed and anti-irritation.
Specifically, the soothing and anti-aging face cream provided by the invention is also added with polyglycerol-3 methyl glucose distearate and sodium bis (lauramide glutamine) lysine, and the components can effectively endow better absorption effect to plant extract components, and the soothing and anti-aging face cream has excellent effects of improving the soothing, anti-irritation and anti-aging effects of the face cream after being compounded.
The face cream of the invention comprises polyglycerol-3 methyl glucose distearate, sodium di (lauramide glutamine) lysine, olive kernel fruit extract, coastal cress extract, dog rose fruit extract and prickly pear stem extract.
Preferably, the cream of the present invention further comprises sodium surfactin, cholesterol, ceramide 1, tocopherol and/or allantoin.
Preferably, the cream of the present invention further comprises a humectant, an emollient, a thickener, a preservative, a chelating agent, a pH adjustor, a fragrance and/or water
Specifically, the face cream comprises the following components in percentage by mass: 0.5-2.5% polyglycerol-3 methyl glucose distearate, 0.5-3% sodium bis (lauramide glutamine) lysine, 0.2-2% olive fruit extract, 0.1-2.5% cress extract, 0.2-2.5% rose hip extract, 0.3-3% cactus stem extract, 0.1-2% sodium surfactin, 0.1-2% cholesterol, 0.1-2% ceramide 1, 0.2-2.5% tocopherol, 0.3-2% allantoin, 2-15% humectant, 3-12% emollient, 1-5% thickener, 0-0.4% preservative, 0-1% chelating agent, 0.1-1% pH regulator, 0-0.1% essence and 40-80% water.
Preferably, the mass ratio of polyglycerol-3 methyl glucose distearate to sodium bis (lauramide glutamine) lysine is 1: (0.8-3), and more preferably the mass ratio of the two is 1: (0.9-2.8), 1: (1-2.5), 1: (1.2-2.2) or 1: (1.5-2).
Preferably, the mass percentage of the polyglycerol-3 methyl glucose distearate in the cream may be 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1.0%, 1.2%, 1.4%, 1.6%, 1.8%, 2.0%, 2.2%, 2.4%, 2.5% of the point value, and a range between any of the above-mentioned point values may be selected, for example, 0.8 to 2.4%, 1 to 2.2%, 1.2 to 2%, etc.
Preferably, the mass percentage of sodium bis (lauramide glutamine) lysine in the cream may be 0.5%, 0.7%, 0.8%, 0.9%, 1.0%, 1.2%, 1.4%, 1.5%, 1.6%, 1.8%, 2.0%, 2.2%, 2.4%, 2.5%, 2.8%, 3.0% of the point value, and a range between any of the above-mentioned point values may be selected, for example, 0.8 to 2.8%, 1 to 2.5%, 1.5 to 2%, etc.
Preferably, the mass percentage of the olive fruit extract in the cream can be 0.2%, 0.3%, 0.4%, 0.5%, 0.7%, 0.9%, 1.0%, 1.2%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2.0%, and the range between any of the above values, for example, 0.4-1.8%, 0.5-1.7%, 0.8-1.5%, etc.
Preferably, the mass percentage of the coastal cress extract in the cream can be 0.1%, 0.2%, 0.4%, 0.5%, 0.7%, 0.9%, 1.0%, 1.2%, 1.4%, 1.6%, 1.8%, 2.0%, 2.2%, 2.4%, 2.5% of the point value, and can also be selected from the range between any of the above point values, such as 0.4-2.2%, 0.5-2.0%, 0.8-1.5% and the like.
Preferably, the mass percentage of the Rosa canina fruit extract in the cream can be 0.2%, 0.4%, 0.5%, 0.7%, 0.8%, 0.9%, 1.0%, 1.2%, 1.4%, 1.6%, 1.8%, 2.0%, 2.2%, 2.4%, 2.5%, and the range between any of the above-mentioned point values, for example, 0.4-2.2%, 0.5-2.0%, 0.8-1.8%, etc.
Preferably, the mass percentage of the Cactus tenuifolia stem extract in the cream may be 0.3%, 0.5%, 0.7%, 0.8%, 0.9%, 1.0%, 1.2%, 1.4%, 1.6%, 1.8%, 2.0%, 2.2%, 2.4%, 2.5%, 2.6%, 2.8%, 3.0% of the point value, and may be selected from the range between any of the above-mentioned point values, for example, 0.5 to 2.5%, 0.8 to 2.0%, 1 to 1.8%, etc.
Preferably, the mass percentage of the sodium surfactin in the cream can be 0.1%, 0.2%, 0.3%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1.0%, 1.2%, 1.4%, 1.5%, 1.6%, 1.8%, 2.0% of the point value, and a range between any of the above point values, for example, 0.5 to 1.8%, 0.6 to 1.6%, 0.8 to 1.5%, and the like can be selected.
Preferably, the mass percentage of cholesterol in the cream may be 0.1%, 0.2%, 0.3%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1.0%, 1.2%, 1.4%, 1.5%, 1.6%, 1.8%, 2.0% of the dot value, and a range between any of the above dot values may be selected, for example, 0.5 to 1.8%, 0.6 to 1.6%, 0.8 to 1.5%, and the like.
Preferably, the mass percentage of the ceramide 1 in the face cream may be 0.1%, 0.2%, 0.3%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1.0%, 1.2%, 1.4%, 1.5%, 1.6%, 1.8%, 2.0% of the point value, and a range between any of the above point values may be selected, for example, 0.5 to 1.8%, 0.6 to 1.6%, 0.8 to 1.5%, etc.
Preferably, the mass percentage of tocopherol in the cream may be 0.2%, 0.3%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1.0%, 1.2%, 1.4%, 1.5%, 1.6%, 1.8%, 2.0%, 2.3%, 2.5% of the point value, and a range between any of the above point values may be selected, for example, 0.5 to 2.3%, 0.6 to 2.0%, 0.8 to 1.5%, and the like.
Preferably, the mass percentage of allantoin in the cream may be 0.3%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1.0%, 1.2%, 1.4%, 1.5%, 1.6%, 1.8%, 2.0% of the point value, and a range between any of the above-mentioned point values may be selected, for example, 0.5 to 1.8%, 0.6 to 1.6%, 0.8 to 1.5%, etc.
Preferably, the mass percentage of the humectant in the cream may be 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15% of the point value, and a range between any of the above point values may be selected, for example, 3 to 15%, 5 to 14%, 6 to 14%, etc. The humectant can be at least one selected from trehalose, biological sugar gum-1, glycerol, sodium hyaluronate, beta-dextran, betaine, and propylene glycol.
Preferably, the mass percent of emollient in the cream may be 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12% of the point value, and ranges between any of the above points may be selected, for example, 4-12%, 5-12%, 6-11%, etc. The emollient is at least one selected from isononyl isononanoate, polydimethylsiloxane, hydrogenated polyisobutene, butter fruit, phytosterol oleate, castor oil, squalane, isopropyl linoleate, and fatty acid lactate.
Preferably, the mass percent of the thickener in the cream may be 1%, 1.5%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5%, 5% of the point value, and a range between any of the above point values may be selected, for example, 1.5-5%, 2-5%, 2.5-5%, etc. The thickener is at least one selected from carbomer, carrageenan, xanthan gum, sodium polyacrylate and ammonium acryloyldimethyl taurate/VP copolymer.
Preferably, the mass percentage of the preservative in the cream may be 0%, 0.05%, 0.1%, 0.15%, 0.2%, 0.25%, 0.3%, 0.35%, 0.4% of the point value, and a range between any of the above-mentioned point values may be selected, for example, 0%, 0.05 to 0.35%, 0.1 to 0.35%, etc. The antiseptic is at least one selected from 1, 2-hexanediol, methyl hydroxybenzoate, ethyl hydroxybenzoate, sodium benzoate, and phenoxyethanol.
Preferably, the mass percentage of the chelating agent in the cream may be 0%, 0.05%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1.0% of the dot value, and a range between any of the above dot values may be selected, for example, 0.1 to 0.9%, 0.2 to 0.8%, 0.3 to 0.7%, and the like. The chelating agent can be at least one selected from disodium EDTA and sodium citrate. Preferably, the mass percentage of the pH adjuster in the cream may be 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1.0% of the point value, and a range between any of the above-mentioned point values may be selected, for example, 0.1 to 0.9%, 0.2 to 0.8%, 0.3 to 0.7%, and the like. The pH regulator is at least one of citric acid, acetic acid, malic acid and tartaric acid.
Preferably, the mass percentage of the essence in the face cream can be 0%, 0.01%, 0.02%, 0.05%, 0.06%, 0.08%, 0.07%, 0.09%, 0.1%, and the range between any of the above values can be selected, for example, 0.01-0.09%, 0.01-0.08%, 0.01-0.07%, etc. The essence can be adjusted according to the requirements of the flavor type.
Preferably, the mass percentage of the water in the face cream is 40-80%, 40-75%, 45-75%, 50-75%, 55-75%, 60-75% and the like. The water may be selected from distilled water, deionized water, ionized water, purified water, pure water, etc.
In another aspect, the present invention provides a method of preparing a soothing, anti-aging cream, the method comprising: (1) Heating water, adding an emollient, polyglycerol-3 methyl glucose distearate and sodium bis (lauramide glutamine) lysine, stirring, and then adding a humectant and a thickener to obtain a mixed solution A; (2) Cooling the mixed solution A, adding sodium surfactin, cholesterol, ceramide 1, tocopherol and allantoin, and continuously stirring to obtain a mixture B; (3) Continuously cooling, then adding the falcate dolichos root fruit extract, the coastal cress extract, the dog rose fruit extract, the Cactus stem extract, the pH regulator and/or the preservative, the chelating agent and the essence, and continuously stirring to obtain the soothing and anti-aging facial cream.
Preferably, the heating temperature in the step (1) is 40-80 ℃, 45-80 ℃, 50-75 ℃ or 50-70 ℃.
Preferably, the temperature of the cooling in the step (2) is 28-39 ℃, 30-38 ℃, 31-37 ℃ or 32-35 ℃ and the like.
Preferably, the temperature of the cooling in the step (3) is 18-27 ℃, 19-26 ℃, 20-25 ℃, 20-24 ℃ or the like.
Preferably, the stirring speeds of the steps (1), (2) and (3) are 500-4000 rpm, 1000-3000 rpm or 1500-2500 rpm.
Preferably, the stirring time of each of the steps (1), (2) and (3) is independently 0.5 to 3 hours, 0.5 to 2.5 hours, 1 to 2 hours or 1 to 1.5 hours.
Preferably, the preparation method of the soothing and anti-aging face cream comprises the following steps: (1) Heating water to 40-80 ℃, adding an emollient, polyglycerol-3 methyl glucose distearate and sodium bis (lauramide glutamine) lysine, stirring for 0.5-3 hours at 500-4000 rpm, and then adding a humectant and a thickener to obtain a mixed solution A; (2) Cooling the mixed solution A to 28-39 ℃, then adding sodium surfactin, cholesterol, ceramide 1, tocopherol and allantoin, and continuously stirring for 0.5-3 hours at 500-4000 rpm to obtain a mixture B; (3) Continuously cooling to 18-27 ℃, then adding the falcate dolichos root fruit extract, the coastal cress extract, the dog rose fruit extract, the Cactus stem extract, the pH regulator and/or the preservative, the chelating agent and the essence, and continuously stirring for 0.5-3 hours at 500-4000 rpm to obtain the soothing and anti-aging face cream.
The beneficial effects are that:
the face cream has excellent moisturizing, antioxidation, anti-aging, soothing and anti-irritation performances. The cream reduced the amount of sample required to reduce the DPPH removal percentage to 50% to 0.29g/mL. The cream produced 50% erythrocyte hemolysis requiring a concentration HD50 as high as 24296mg/L and a protein denaturation index DI as low as 0.70%.
The polyglycerol-3 methyl glucose distearate and sodium bis (lauramide glutamine) lysine are compounded to have synergistic effect, so that the cream has excellent antioxidation and antisenescence properties, and the performances of relieving, resisting stimulation and the like, and the active ingredients of the cream can be distributed more uniformly by compounding the two, so that the active ingredients can play a better role, and the active ingredients of the cream can be distributed more easily and can be absorbed by skin better to generate better effect. The mass ratio of the polyglycerol-3 methyl glucose distearate to the sodium bis (lauramide glutamine) lysine is 1: the range of (0.8-3) enables the cream of the present invention to have a better effect.
The invention has synergistic effect by compounding the extract of the falcate elemene fruit and the extract of the coastal cress, and can lead the face cream of the invention to have unexpected oxidation resistance increase. The Rosa canina fruit extract and the Cactus tenuifolia stem extract have synergistic effect, so that the soothing and anti-irritation effects of the facial cream are obviously improved.
Detailed Description
The advantages and various effects of the present invention will be more clearly apparent from the following detailed description and examples. It will be understood by those skilled in the art that these specific embodiments and examples are intended to illustrate the invention, not to limit the invention.
Throughout the specification, unless specifically indicated otherwise, the terms used herein should be understood as meaning as commonly used in the art. Accordingly, unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. In case of conflict, the present specification will control.
Unless otherwise specifically indicated, the various raw materials, reagents, instruments, equipment and the like used in the present invention are commercially available or may be prepared by existing methods. Wherein, the extract of the test group method of the invention is derived from Shaanxi Yongyuan biotechnology limited company; the coastal cress extract is derived from Shenzhen Crigit Biotechnology Co., ltd; the Rosa canina fruit extract is from the company Siam Tianrui biotechnology Co; the Cactus stem extract is from Shaanxi Xinkang biotechnology Co.
Table 1: composition of test group face cream
Continuing with table 1: composition of test group face cream
The preparation method of the test group face cream comprises the following steps: (1) Heating water to 70 ℃, adding an emollient, polyglycerol-3 methyl glucose distearate and/or sodium bis (lauramide glutamine) lysine, stirring for 1.5 hours at a rotating speed of 1500 rpm, and then adding a humectant and a thickener to obtain a mixed solution A; (2) Cooling the mixed solution A to 32 ℃, then adding sodium surfactin, cholesterol, ceramide 1, tocopherol and allantoin, and continuously stirring for 0.5 hour at a rotating speed of 1000 revolutions per minute to obtain a mixture B; (3) Continuously cooling to 25 ℃, then adding the falcate elemene fruit extract and/or the coastal cress extract and/or the dog rose fruit extract and/or the prickly pear stem extract, the pH regulator, the preservative, the chelating agent and the essence, and continuously stirring for 0.5 hour at the rotation speed of 1000 revolutions per minute to obtain the soothing and anti-aging face cream.
Anti-aging experimental test:
the invention characterizes its anti-aging properties by analyzing the free radical scavenging ability. 0.1mmol/L DPPH (1, 1-diphenyl-2-trinitrophenylhydrazine) solution is prepared by 60 percent ethanol, and the solution is preserved in a dark place. Measuring the absorbance A0 of DPPH at 520nm, taking 0.1-5g of test sample (face cream of the test group) and 1mL of DPPH solution, adding into the same test tube, shaking uniformly, standing in dark at room temperature for 30min, and measuring the absorbance A. The percent DPPH clearance (%) = (A0-a)/A0 x 100% was calculated and then the amount of sample required to reduce the percent DPPH clearance to 50% was used as an index for investigation. The amount of sample (cream of the test group of the present invention) required is shown in table 2.
Table 2: anti-aging test for test group of creams
As can be seen from the antioxidant test of the test group in Table 2 of the present invention, the cream of the present invention has excellent antioxidant properties, and the required amount of the sample for which DPPH clearance percentage is reduced to 50% can be reduced to 0.29g/mL.
As can be seen from a comparison of test group 1 and test groups 7-8, the combination of the polyglycerol-3 methyl glucose distearate and sodium bis (lauramide glutamine) lysine according to the present invention has a synergistic effect, which can provide the cream with excellent anti-oxidation properties, probably because the combination of the two can provide the active ingredients of the cream with a more uniform distribution, thereby providing better effects of the active ingredients, and the active ingredients of the cream can be more easily distributed and absorbed by the skin to provide better effects. As can be seen from a comparison of test groups 1, 4 and test groups 5-6, the mass ratio of polyglycerol-3 methylglucose distearate to sodium di (lauramide glutamine) lysine of the present invention is 1: the range of (0.8-3) enables the cream of the present invention to have a better effect.
As can be seen from the comparison of the test group 1 and the test groups 9-10, the combination of the inventive olive kernel extract and the coastal cress extract has a synergistic effect, so that the inventive facial cream has unexpected oxidation resistance increase.
Anti-irritation Property test: including erythrocyte hemolysis tests and protein denaturation tests.
(1) Erythrocyte hemolysis assay: preparation of erythrocyte suspensions: healthy rabbits are selected, 9mL of heart blood is taken, 1mL of 2% potassium oxalate solution is added, centrifugation is carried out, supernatant fluid is removed, 20mmol/L PBS solution is used for diluting sediment to 20mL, and the sediment is preserved at 4 ℃ for standby. The face cream of the test set of the invention was selected as a sample to be diluted with PBS solution to different concentrations, each sample being set with 5 concentration gradients. Taking 10mL of the dilution of the sample to be tested, adding 200 μl of the above erythrocyte suspension (controlling the final concentration of the sample to be 5, 10, 20, 50, 100mg/mL respectively), taking distilled water as total hemolysis control, taking PBS solution as negative control, gently mixing, incubating at 37deg.C for 30min, centrifuging at 2000r/min for 10min, collecting supernatant, and measuring its absorbance at 560nm with spectrophotometer (A 560 ) Calculating the hemolysis rate according to the following formula; hemolysis rate=100% (experimental group a 560 Negative control group A 560 ) (Whole hemolysis control group A) 560 Negative control group A 560 ). Then, a standard curve of the hemolysis ratio-sample concentration was drawn, and the sample concentration HD50 at which 50% of the erythrocytes were hemolyzed was calculated.
(2) Protein denaturation experiment: the face cream of the test group is selected as a sample, diluted to 10g/L by PBS solution, 10mL of the diluted solution of the sample to be tested is taken, 200 mu L of the erythrocyte suspension is added, distilled water is used as a blank control, 1mg/mL Sodium Dodecyl Sulfate (SDS) solution is used as a positive control, the mixture is gently mixed, incubated for 30min at 37 ℃, centrifuged for 10min at 2000r/min, the supernatant is taken, and the absorbance A of the supernatant at 540nm and 575nm is respectively tested by a spectrophotometer 540 And A 575 Calculating a protein Denaturation Index (DI) according to the following formula; di=100% (R1-R2)/(R1-R3). Wherein r1=blank control group a 575 Blank group A 540 R2=experimental group a 575 Experimental group A 540 R3=positive control group a 575 Positive control group A 540 。
The test results of the above-described erythrocyte hemolysis test and protein denaturation test are shown in table 3 below:
table 3: erythrocyte hemolysis and protein denaturation test for test group face cream
Test set HD50/mg/L DI/％
Test group 1 24296 0.70
Test group 2 22139 0.79
Test group 3 22958 0.73
Test group 4 22617 0.75
Test group 5 22306 0.78
Test group 6 21852 0.80
Test group 7 21053 0.86
Test group 8 19872 0.88
Test group 9 23368 0.72
Test set 10 23826 0.71
Test group 11 19367 0.93
Test set 12 19014 0.95
As is clear from the anti-irritation test of the test group in Table 3 of the present invention, the cream of the present invention has excellent soothing and anti-irritation effects, and the cream makes the concentration HD50 required for 50% erythrocyte hemolysis as high as 24296mg/L, and the protein denaturation index DI as low as 0.70%.
As can be seen from a comparison of test group 1 and test groups 7-8, the combination of the polyglycerol-3 methyl glucose distearate and sodium bis (lauramide glutamine) lysine according to the present invention has a synergistic effect, which can provide the cream with excellent soothing and anti-irritant effects, probably because the combination of the two can provide the active ingredients of the cream with a more uniform distribution, thereby providing a better effect of the active ingredients, and the active ingredients of the cream can be more easily distributed and absorbed by the skin to provide a better effect. As can be seen from a comparison of test groups 1, 4 and test groups 5-6, the mass ratio of polyglycerol-3 methylglucose distearate to sodium di (lauramide glutamine) lysine of the present invention is 1: the range of (0.8-3) enables the cream of the present invention to have a better effect.
As can be seen from the comparison of the test group 1 and the test groups 1-12, the combination of the Rosa canina fruit extract and the Cactus with twisted stems has a synergistic effect, so that the facial cream has unexpected increase of the soothing and anti-irritation effects.
Finally, it is also noted that the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.
While preferred embodiments of the present invention have been described, additional variations and modifications in those embodiments may occur to those skilled in the art once they learn of the basic inventive concepts. It is therefore intended that the following claims be interpreted as including the preferred embodiments and all such alterations and modifications as fall within the scope of the invention.
It will be apparent to those skilled in the art that various modifications and variations can be made to the present invention without departing from the spirit or scope of the invention. Thus, it is intended that the present invention also include such modifications and alterations insofar as they come within the scope of the appended claims or the equivalents thereof.

Claims (9)

1. A soothing and anti-aging facial cream, characterized in that: the face cream comprises the following components in percentage by mass: 0.5-2.5% polyglycerol-3 methyl glucose distearate, 0.5-3% sodium bis (lauramide glutamine) lysine, 0.2-2% olive fruit extract, 0.1-2.5% cress extract, 0.2-2.5% rose hip extract, 0.3-3% cactus stem extract, 0.1-2% sodium surfactin, 0.1-2% cholesterol, 0.1-2% ceramide 1, 0.2-2.5% tocopherol, 0.3-2% allantoin, 2-15% humectant, 3-12% emollient, 1-5% thickener, 0-0.4% preservative, 0-1% chelating agent, 0.1-1% pH regulator, 0-0.1% essence and 40-80% water; the mass ratio of the polyglycerol-3 methyl glucose distearate to the sodium bis (lauramide glutamine) lysine is 1: (0.8-3).
2. The cream of claim 1, wherein: the humectant is at least one of trehalose, biological sugar gum-1, glycerol, sodium hyaluronate, beta-dextran, betaine and propylene glycol.
3. The cream of claim 1, wherein: the emollient is at least one of isononyl isononanoate, polydimethylsiloxane, hydrogenated polyisobutene, butter fruit, phytosterol oleate, castor oil, squalane, isopropyl linoleate and fatty acid lactate.
4. The cream of claim 1, wherein: the thickener is at least one of carbomer, carrageenan, xanthan gum, sodium polyacrylate and ammonium acryloyldimethyl taurate/VP copolymer.
5. The cream of claim 1, wherein: the antiseptic is at least one of 1, 2-hexanediol, methyl hydroxybenzoate, ethyl hydroxybenzoate, sodium benzoate, and phenoxyethanol.
6. The cream of claim 1, wherein: the chelating agent is at least one of EDTA disodium and sodium citrate;
and/or the pH regulator is at least one of citric acid, acetic acid, malic acid and tartaric acid.
7. A method of preparing a cream as claimed in claim 1, wherein: the preparation method comprises the following steps: (1) Heating water, adding an emollient, polyglycerol-3 methyl glucose distearate and sodium bis (lauramide glutamine) lysine, stirring, and then adding a humectant and a thickener to obtain a mixed solution A; (2) Cooling the mixed solution A, adding sodium surfactin, cholesterol, ceramide 1, tocopherol and allantoin, and continuously stirring to obtain a mixture B; (3) Continuously cooling, then adding the falcate dolichos root extract, the coastal cress extract, the dog rose fruit extract, the Cactus stem extract, the pH regulator, the preservative, the chelating agent and the essence, and continuously stirring to obtain the soothing and anti-aging facial cream.
8. The method of claim 7, wherein: the heating temperature in the step (1) is 40-80 ℃.
9. The method of claim 7, wherein: the stirring speeds of the steps (1), (2) and (3) are respectively and independently 500-4000 rpm.
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