CN112315835A - Oil-control and anti-dandruff composition and application thereof - Google Patents
Oil-control and anti-dandruff composition and application thereof Download PDFInfo
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- CN112315835A CN112315835A CN202011354603.3A CN202011354603A CN112315835A CN 112315835 A CN112315835 A CN 112315835A CN 202011354603 A CN202011354603 A CN 202011354603A CN 112315835 A CN112315835 A CN 112315835A
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- oil
- dandruff
- control
- controlling
- phase
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- 208000001840 Dandruff Diseases 0.000 title claims abstract description 170
- 239000000203 mixture Substances 0.000 title claims abstract description 116
- 239000002453 shampoo Substances 0.000 claims abstract description 49
- 229940043810 zinc pyrithione Drugs 0.000 claims abstract description 27
- PICXIOQBANWBIZ-UHFFFAOYSA-N zinc;1-oxidopyridine-2-thione Chemical compound [Zn+2].[O-]N1C=CC=CC1=S.[O-]N1C=CC=CC1=S PICXIOQBANWBIZ-UHFFFAOYSA-N 0.000 claims abstract description 27
- SAVLIIGUQOSOEP-UHFFFAOYSA-N N-octanoylglycine Chemical compound CCCCCCCC(=O)NCC(O)=O SAVLIIGUQOSOEP-UHFFFAOYSA-N 0.000 claims abstract description 25
- -1 saccharide isomerate Chemical compound 0.000 claims abstract description 25
- 239000001198 melaleuca alternifolia leaf oil Substances 0.000 claims abstract description 24
- 239000000294 eucalyptus globulus labille leaf/twig oil Substances 0.000 claims abstract description 21
- 210000004761 scalp Anatomy 0.000 claims abstract description 15
- 229940094944 saccharide isomerate Drugs 0.000 claims abstract description 7
- 238000002156 mixing Methods 0.000 claims description 25
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 25
- 238000000034 method Methods 0.000 claims description 17
- 238000002360 preparation method Methods 0.000 claims description 15
- 239000003795 chemical substances by application Substances 0.000 claims description 14
- 238000001816 cooling Methods 0.000 claims description 14
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 11
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 11
- 239000000375 suspending agent Substances 0.000 claims description 11
- 239000004698 Polyethylene Substances 0.000 claims description 10
- 239000003945 anionic surfactant Substances 0.000 claims description 10
- 239000002736 nonionic surfactant Substances 0.000 claims description 10
- 229920000573 polyethylene Polymers 0.000 claims description 10
- 239000003755 preservative agent Substances 0.000 claims description 10
- 230000002335 preservative effect Effects 0.000 claims description 10
- 229940046000 sodium isostearoyl lactylate Drugs 0.000 claims description 10
- FOSNFLMXYRQNAF-UHFFFAOYSA-M sodium;2-[2-(16-methylheptadecanoyloxy)propanoyloxy]propanoate Chemical compound [Na+].CC(C)CCCCCCCCCCCCCCC(=O)OC(C)C(=O)OC(C)C([O-])=O FOSNFLMXYRQNAF-UHFFFAOYSA-M 0.000 claims description 10
- 239000002562 thickening agent Substances 0.000 claims description 10
- 239000002888 zwitterionic surfactant Substances 0.000 claims description 10
- 150000001720 carbohydrates Chemical class 0.000 claims description 9
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 9
- 239000002537 cosmetic Substances 0.000 claims description 9
- 244000303965 Cyamopsis psoralioides Species 0.000 claims description 8
- 238000004321 preservation Methods 0.000 claims description 8
- VFKZECOCJCGZQK-UHFFFAOYSA-M 3-hydroxypropyl(trimethyl)azanium;chloride Chemical compound [Cl-].C[N+](C)(C)CCCO VFKZECOCJCGZQK-UHFFFAOYSA-M 0.000 claims description 7
- 238000010438 heat treatment Methods 0.000 claims description 6
- JDRSMPFHFNXQRB-CMTNHCDUSA-N Decyl beta-D-threo-hexopyranoside Chemical compound CCCCCCCCCCO[C@@H]1O[C@H](CO)C(O)[C@H](O)C1O JDRSMPFHFNXQRB-CMTNHCDUSA-N 0.000 claims description 5
- 229940073499 decyl glucoside Drugs 0.000 claims description 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 4
- 230000003750 conditioning effect Effects 0.000 claims description 4
- 229940075285 dandruff control Drugs 0.000 claims description 4
- 230000009467 reduction Effects 0.000 claims description 3
- 239000001509 sodium citrate Substances 0.000 claims description 3
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 3
- WCOXQTXVACYMLM-UHFFFAOYSA-N 2,3-bis(12-hydroxyoctadecanoyloxy)propyl 12-hydroxyoctadecanoate Chemical compound CCCCCCC(O)CCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCC(O)CCCCCC)COC(=O)CCCCCCCCCCC(O)CCCCCC WCOXQTXVACYMLM-UHFFFAOYSA-N 0.000 claims description 2
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 claims description 2
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims description 2
- FPVVYTCTZKCSOJ-UHFFFAOYSA-N Ethylene glycol distearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCOC(=O)CCCCCCCCCCCCCCCCC FPVVYTCTZKCSOJ-UHFFFAOYSA-N 0.000 claims description 2
- 229920002907 Guar gum Polymers 0.000 claims description 2
- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 claims description 2
- 229940073507 cocamidopropyl betaine Drugs 0.000 claims description 2
- 238000009472 formulation Methods 0.000 claims description 2
- 239000000665 guar gum Substances 0.000 claims description 2
- 229960002154 guar gum Drugs 0.000 claims description 2
- 235000010417 guar gum Nutrition 0.000 claims description 2
- 239000003002 pH adjusting agent Substances 0.000 claims description 2
- 229960005323 phenoxyethanol Drugs 0.000 claims description 2
- 239000004302 potassium sorbate Substances 0.000 claims description 2
- 229940069338 potassium sorbate Drugs 0.000 claims description 2
- 235000010241 potassium sorbate Nutrition 0.000 claims description 2
- 239000011780 sodium chloride Substances 0.000 claims description 2
- 229940057950 sodium laureth sulfate Drugs 0.000 claims description 2
- SXHLENDCVBIJFO-UHFFFAOYSA-M sodium;2-[2-(2-dodecoxyethoxy)ethoxy]ethyl sulfate Chemical compound [Na+].CCCCCCCCCCCCOCCOCCOCCOS([O-])(=O)=O SXHLENDCVBIJFO-UHFFFAOYSA-M 0.000 claims description 2
- 229940057400 trihydroxystearin Drugs 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 33
- 208000003251 Pruritus Diseases 0.000 abstract description 14
- 230000007794 irritation Effects 0.000 abstract description 8
- 230000028327 secretion Effects 0.000 abstract description 8
- 230000002195 synergetic effect Effects 0.000 abstract description 8
- 241000233866 Fungi Species 0.000 abstract description 7
- 230000003020 moisturizing effect Effects 0.000 abstract description 7
- 238000011156 evaluation Methods 0.000 abstract description 6
- 230000014759 maintenance of location Effects 0.000 abstract description 5
- 206010019049 Hair texture abnormal Diseases 0.000 abstract description 4
- 239000006260 foam Substances 0.000 abstract description 4
- 238000011161 development Methods 0.000 abstract description 2
- 239000003921 oil Substances 0.000 description 30
- 230000000052 comparative effect Effects 0.000 description 27
- 238000012360 testing method Methods 0.000 description 24
- 210000003491 skin Anatomy 0.000 description 11
- 230000001580 bacterial effect Effects 0.000 description 9
- 239000000725 suspension Substances 0.000 description 9
- 230000008569 process Effects 0.000 description 8
- 239000000047 product Substances 0.000 description 8
- 238000003756 stirring Methods 0.000 description 8
- 230000003385 bacteriostatic effect Effects 0.000 description 7
- 244000166124 Eucalyptus globulus Species 0.000 description 6
- 235000004692 Eucalyptus globulus Nutrition 0.000 description 6
- 241000894006 Bacteria Species 0.000 description 5
- 241000555688 Malassezia furfur Species 0.000 description 5
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 5
- 230000000844 anti-bacterial effect Effects 0.000 description 5
- 239000004519 grease Substances 0.000 description 5
- 230000005764 inhibitory process Effects 0.000 description 5
- 206010067484 Adverse reaction Diseases 0.000 description 4
- 230000006838 adverse reaction Effects 0.000 description 4
- 230000000875 corresponding effect Effects 0.000 description 4
- 238000007689 inspection Methods 0.000 description 4
- OYINQIKIQCNQOX-UHFFFAOYSA-M 2-hydroxybutyl(trimethyl)azanium;chloride Chemical compound [Cl-].CCC(O)C[N+](C)(C)C OYINQIKIQCNQOX-UHFFFAOYSA-M 0.000 description 3
- 241000555676 Malassezia Species 0.000 description 3
- 229940051368 capryloyl glycine Drugs 0.000 description 3
- 230000001276 controlling effect Effects 0.000 description 3
- 230000002401 inhibitory effect Effects 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 230000000813 microbial effect Effects 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- 241000366182 Melaleuca alternifolia Species 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 238000012258 culturing Methods 0.000 description 2
- 238000007599 discharging Methods 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 210000000245 forearm Anatomy 0.000 description 2
- 210000002510 keratinocyte Anatomy 0.000 description 2
- 230000000670 limiting effect Effects 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 231100000344 non-irritating Toxicity 0.000 description 2
- 238000004806 packaging method and process Methods 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 230000001953 sensory effect Effects 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 239000000341 volatile oil Substances 0.000 description 2
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 description 2
- 201000004384 Alopecia Diseases 0.000 description 1
- 241000228245 Aspergillus niger Species 0.000 description 1
- 238000012935 Averaging Methods 0.000 description 1
- 241000222122 Candida albicans Species 0.000 description 1
- 238000005773 Enders reaction Methods 0.000 description 1
- 241000191070 Escherichia coli ATCC 8739 Species 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Natural products NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 206010035148 Plague Diseases 0.000 description 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- 206010040844 Skin exfoliation Diseases 0.000 description 1
- 206010040914 Skin reaction Diseases 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 241000607479 Yersinia pestis Species 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000002390 adhesive tape Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 231100000360 alopecia Toxicity 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O ammonium group Chemical class [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000003266 anti-allergic effect Effects 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- 239000003429 antifungal agent Substances 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 239000010684 cajeput oil Substances 0.000 description 1
- 229940095731 candida albicans Drugs 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 239000007933 dermal patch Substances 0.000 description 1
- 230000035618 desquamation Effects 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 230000007760 free radical scavenging Effects 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 230000003780 keratinization Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 150000004671 saturated fatty acids Chemical class 0.000 description 1
- 210000001732 sebaceous gland Anatomy 0.000 description 1
- 239000003079 shale oil Substances 0.000 description 1
- 230000035483 skin reaction Effects 0.000 description 1
- 231100000430 skin reaction Toxicity 0.000 description 1
- 230000003997 social interaction Effects 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 229940080352 sodium stearoyl lactylate Drugs 0.000 description 1
- ODFAPIRLUPAQCQ-UHFFFAOYSA-M sodium stearoyl lactylate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC(=O)OC(C)C(=O)OC(C)C([O-])=O ODFAPIRLUPAQCQ-UHFFFAOYSA-M 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 239000002344 surface layer Substances 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 239000011592 zinc chloride Substances 0.000 description 1
- 235000005074 zinc chloride Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/006—Antidandruff preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/008—Preparations for oily hair
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/02—Preparations for cleaning the hair
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/12—Preparations containing hair conditioners
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Cosmetics (AREA)
Abstract
The invention relates to an oil-control and anti-dandruff composition and application thereof, wherein the oil-control and anti-dandruff composition comprises zinc pyrithione, melaleuca alternifolia oil, saccharide isomerate, caprylyl glycine and eucalyptus globulus oil, and all the components are synergistic synergistically, so that the oil-control and anti-dandruff composition can effectively inhibit fungi and oil secretion, realizes efficient anti-dandruff, has the effects of moisturizing and anti-pruritus, and is low in irritation and high in safety. The oil-control and dandruff-removing shampoo containing the oil-control and dandruff-removing composition is excellent in spreadability, foam richness, wet hair smoothness, dry hair smoothness, oil-control effect, dandruff-removing effect, anti-itching effect and scalp moisture retention, is relatively high in evaluation of testers, and has wide development prospects in the field of oil-control and dandruff-removing products.
Description
Technical Field
The invention belongs to the technical field of daily cosmetics, and relates to an oil-controlling and dandruff-removing composition and application thereof.
Background
The problem of dandruff often plagues people in all aspects of work, life, and social interaction. Malassezia is one of the main causes of pathological dandruff, is unicellular yeast, also called pityrosporum orbicularis, and absorbs fatty acid from sebaceous gland lipid, after saturated fatty acid is consumed, the residual unsaturated fatty acid permeates into scalp to cause inflammatory reaction, thereby causing abnormal phenomena of scalp cell proliferation, incomplete keratinization of keratinocytes and other physiological structures of scalp, finally causing large-area desquamation of surface cells to form dandruff. Research shows that both the inhibition of oil secretion and the use of antifungal agents can improve the dandruff caused by malassezia.
CN111265439A discloses an oil-control, dandruff-removal and itching-relieving shampoo and a preparation method thereof, wherein the oil-control, dandruff-removal and itching-relieving shampoo comprises sodium lauryl sulfate, cocamide MEA, polyquaternary ammonium salt-10, zinc pyrithione, zinc chloride, hydrolyzed rice protein, caprylyl glycine and shale oil sodium sulfonate, can slow down grease secretion, but has a low inhibition effect on malassezia and a limited dandruff-removal effect.
CN105997596A discloses a plant essential oil synergistic anti-dandruff composition, which comprises, by mass, 2.0-20.0% of zinc pyrithione, 5.0-15.0% of a plant essential oil composition, 0.3-2.0% of a suspending agent and 63.0-92.7% of water or/and alcohol, has antibacterial and anti-dandruff functions, but does not have the effects of oil control, moisture retention, pruritus resistance and the like.
In conclusion, the oil-control and anti-dandruff composition capable of effectively inhibiting fungi and oil secretion and having the effects of moisturizing and resisting pruritus is provided, high-efficiency dandruff removal is achieved, and the oil-control and anti-dandruff composition has important significance for the field of anti-dandruff cosmetics.
Disclosure of Invention
Aiming at the defects and actual requirements of the prior art, the invention provides an oil-control and dandruff-removing composition and application thereof, wherein the oil-control and dandruff-removing composition can effectively inhibit fungi and grease secretion, realizes efficient dandruff removal, has the effects of moisturizing and resisting pruritus, has low irritation, can resist microbial pollution, and has wide application prospects in the field of dandruff-removing cosmetics.
In order to achieve the purpose, the invention adopts the following technical scheme:
in a first aspect, the present invention provides an oil-control and anti-dandruff composition comprising zinc pyrithione, melaleuca alternifolia oil, saccharide isomers, caprylylglycine, and eucalyptus globulus oil.
In the oil-control and dandruff-removing composition, the zinc pyrithione can effectively resist bacteria and improve the dandruff problem caused by fungi; the melaleuca alternifolia leaf oil is a natural antibacterial agent and an anti-inflammatory agent, and can effectively sterilize and resist bacteria; the saccharide isomerate is efficiently combined with the surface layer of the skin, and can supplement water, lock water, strengthen the barrier function of the skin for a long time and balance scalp microorganisms; caprylyl glycine has an amphiphilic structure, and can regulate the skin ecosystem, relieve scalp, inhibit dandruff and reduce alopecia; the Eucalyptus globulus Labill leaf oil has antiallergic and antibacterial effects, can promote keratinocyte proliferation, has free radical scavenging effect, and can prevent aging.
According to the invention, the melaleuca alternifolia oil and the eucalyptus globulus labill oil are natural plant extracts and are rich in various beneficial components and relieving factors, and the zinc pyrithione, the melaleuca alternifolia oil and the eucalyptus globulus labill oil are mutually matched, so that the irritation of the oil-control and anti-dandruff composition can be effectively reduced, and various microbial pollutions can be resisted; meanwhile, the saccharide isomer and the caprylyl glycine can inhibit the secretion of scalp grease, regulate the skin environment and destroy the breeding conditions of fungi.
The components in the oil-control and anti-dandruff composition are synergistic, so that the oil-control and anti-dandruff composition can effectively inhibit fungi and grease secretion, and can realize high-efficiency antibacterial and anti-dandruff effects from multiple aspects, and the oil-control and anti-dandruff composition has the effects of moisturizing and anti-itching, and is low in irritation and high in safety.
Preferably, the mass ratio of the zinc pyrithione to the melaleuca alternifolia oil, the saccharide isomerate, the caprylyl glycine to the eucalyptus globulus leaf oil is (0.2-0.5): (0.1-6): 0.5-12): 0.1-1): 0.3-5, including but not limited to 0.3:1.1:1.0:0.8:3.5, 0.4:1.4:2.0:0.6:4.8, 0.45:2.1:5.0:0.3:4, 0.35:4.5:8.0:0.5:4.5 or 0.25:1.5:11.0:0.9: 3.2.
Preferably, the mass percentage of the zinc pyrithione in the oil-control and anti-dandruff composition is 0.2% to 0.5%, including but not limited to 0.25%, 0.3%, 0.35%, 0.4% or 0.45%.
Preferably, the weight percentage of the melaleuca alternifolia oil in the oil-control and anti-dandruff composition is 0.1% to 6%, including but not limited to 0.2%, 0.4%, 0.6%, 1%, 1.4%, 1.8%, 2%, 2.5%, 3%, 4%, 4.5% or 5%.
Preferably, the mass percentage of said saccharide isomer in said oil-control and dandruff-control composition is between 0.5% and 12%, including but not limited to 0.6%, 0.7%, 0.8%, 1.0%, 3%, 5%, 8%, 9%, 10% or 11%.
Preferably, the weight percentage of the capryloyl glycine in the oil-control and anti-dandruff composition is 0.1% -1.0%, including but not limited to 0.2%, 0.3%, 0.5%, 0.6%, 0.7%, 0.8% or 0.9%.
Preferably, the mass percentage of the eucalyptus globulus labill oil in the oil-controlling and anti-dandruff composition is 0.3% -5%, including but not limited to 0.4%, 0.6%, 0.8%, 1%, 1.2%, 1.8%, 2.5%, 3%, 3.5%, 4%, 4.2%, 4.5% or 4.8%.
Preferably, the saccharide isomers comprise
By the affinity action with the skin, the instant and deep moisturizing effect can be realized, the skin chapping and the pruritus can be reduced, the scalp can be deeply moisturized, and the scalp sensitivity can be slowed down.
Preferably, the oil control and antidandruff composition further comprises water.
Preferably, the mass percentage of the water in the oil-controlling and anti-dandruff composition is 76% -90%, including but not limited to 77%, 78%, 80%, 82%, 85%, 88% or 89%.
Preferably, the oil-control and anti-dandruff composition comprises, by mass, 0.2-0.5% of zinc pyrithione, 0.1-6% of melaleuca alternifolia oil, 0.5-12% of saccharide isomer humectant, 0.1-1.0% of caprylyl glycine, 0.3-5% of eucalyptus globulus oil, and the balance of water.
Preferably, the oil-control and anti-dandruff composition comprises, by mass, 0.2-0.5% of zinc pyrithione, 0.1-6% of melaleuca alternifolia oil,
0.5 to 12 percent of the total weight of the composition, 0.1 to 1.0 percent of caprylyl glycine, 0.3 to 5 percent of eucalyptus globulus leaf oil and the balance of water.
In a second aspect, the present invention provides the use of an oil-controlling and anti-dandruff composition according to the first aspect in the preparation of an oil-controlling and anti-dandruff cosmetic.
Preferably, the formulation of the oil-controlling and dandruff-removing cosmetic comprises any one of shampoo, hair conditioner or scalp care solution, and is preferably shampoo.
In a third aspect, the invention provides an oil-control and anti-dandruff shampoo, which comprises the oil-control and anti-dandruff composition of the first aspect.
Preferably, the oil-controlling and dandruff-removing composition is present in the oil-controlling and dandruff-removing shampoo in an amount of 13% to 20% by weight, including but not limited to 14%, 15%, 16%, 17% or 18%.
Preferably, the oil-control and anti-dandruff shampoo further comprises an anionic surfactant, a nonionic surfactant, a zwitterionic surfactant, a conditioning agent, a preservative, essence, a suspending agent, a pearling agent, a thickening agent, a pH regulator and water.
Preferably, the anionic surfactant comprises sodium laureth sulfate.
Preferably, the nonionic surfactant comprises any one of or a combination of at least two of cocamide MEA, cocamide methyl MEA, or decyl glucoside, wherein typical but non-limiting combinations include combinations of cocamide MEA and cocamide methyl MEA, cocamide MEA and decyl glucoside, or combinations of cocamide methyl MEA and decyl glucoside, preferably combinations of cocamide MEA, cocamide methyl MEA, and decyl glucoside.
Preferably, the zwitterionic surfactant comprises cocamidopropyl betaine.
Preferably, the conditioning agent comprises any one of, or a combination of at least two of, guar hydroxypropyl trimonium chloride, polyethylene glycol-14M, sodium isostearoyl lactylate, polydimethylsiloxane, or polyquaternium-7, wherein typical but non-limiting combinations include a combination of guar hydroxypropyl trimonium chloride and polyethylene glycol-14M, a combination of sodium isostearoyl lactylate and polydimethylsiloxane, or a combination of sodium stearoyl lactylate and polydimethylsiloxane, preferably a combination of guar hydroxypropyl trimonium chloride, polyethylene glycol-14M, sodium isostearoyl lactylate, polydimethylsiloxane, and polyquaternium-7.
Preferably, the preservative comprises phenoxyethanol and/or potassium sorbate.
Preferably, the suspending agent comprises trihydroxystearin.
Preferably, the pearlescent agent comprises ethylene glycol distearate.
Preferably, the thickener comprises sodium chloride.
Preferably, the pH adjusting agent comprises citric acid and/or sodium citrate.
In a fourth aspect, the invention provides a preparation method of the oil-control and anti-dandruff shampoo of the third aspect, and the preparation method comprises the following steps:
(1) mixing guar hydroxypropyl trimethyl ammonium chloride with water, sequentially adding polyethylene glycol-14M and anionic surfactant, mixing, and heating to obtain phase A;
(2) adding a zwitterionic surfactant, a nonionic surfactant, a pearling agent and a suspending agent into the phase A, mixing and preserving heat to obtain a phase B;
(3) cooling the phase B, adding the oil-control and anti-dandruff composition in the first aspect, mixing and preserving heat to obtain a phase C;
(4) cooling the phase C, adding sodium isostearoyl lactylate, polydimethylsiloxane and polyquaternium-7, and mixing to obtain phase D;
(5) and adding a preservative, essence and a thickening agent into the phase D, and adjusting the pH by using a pH regulator to obtain the oil-controlling and anti-dandruff shampoo.
Preferably, the temperature in step (1) is raised to 80-85 ℃, including but not limited to 81 ℃, 82 ℃, 83 ℃ or 84 ℃.
Preferably, the temperature of the heat preservation in the step (2) is 80-85 ℃, including but not limited to 81 ℃, 82 ℃, 83 ℃ or 84 ℃.
Preferably, the time for the heat preservation in the step (2) is 25-35 min, including but not limited to 26min, 27min, 28min, 30min, 32min, 33min or 34 min.
Preferably, the temperature of the heat preservation in the step (3) is 70-75 ℃, including but not limited to 71 ℃, 72 ℃, 73 ℃ or 74 ℃.
Preferably, the time for the heat preservation in the step (3) is 5-10 min, including but not limited to 6min, 7min, 8min or 9 min.
Preferably, the temperature of the temperature reduction treatment in the step (4) is 40-50 ℃, including but not limited to 41 ℃, 42 ℃, 43 ℃, 45 ℃, 46 ℃, 47 ℃, 48 ℃ or 49 ℃.
Preferably, the pH of step (5) is 5.0-6.5, including but not limited to 5.2, 5.3, 5.7, 6.0, 6.2, or 6.4.
As a preferable technical scheme, the preparation method of the oil-control and anti-dandruff shampoo comprises the following steps:
(1) mixing guar gum hydroxypropyl trimethyl ammonium chloride with water, sequentially adding polyethylene glycol-14M and an anionic surfactant, mixing, and heating to 80-85 ℃ to obtain a phase A;
(2) adding a zwitterionic surfactant, a nonionic surfactant, a pearling agent and a suspending agent into the phase A, mixing, and keeping the temperature at 80-85 ℃ for 25-35 min to obtain a phase B;
(3) cooling the phase B to 70-75 ℃, adding the oil-controlling and anti-dandruff composition in the first aspect, mixing, and keeping the temperature for 5-10 min to obtain a phase C;
(4) cooling the phase C to 40-50 ℃, adding sodium isostearoyl lactylate, polydimethylsiloxane and polyquaternium-7, and mixing to obtain a phase D;
(5) and adding a preservative, essence and a thickening agent into the phase D, and adjusting the pH to 5.0-6.5 by using a pH regulator to obtain the oil-control and anti-dandruff shampoo.
Compared with the prior art, the invention has at least the following beneficial effects:
(1) in the oil-control and anti-dandruff composition, the components are synergistic, so that the oil-control and anti-dandruff composition can effectively inhibit fungi and grease secretion, realizes efficient anti-dandruff, has the effects of moisturizing and resisting pruritus, and is low in irritation and strong in safety;
(2) the oil-control and anti-dandruff shampoo containing the oil-control and anti-dandruff composition has low irritation, and the patch test results are negative; the effect of inhibiting malassezia furfur is strong, the diameter of an inhibition zone is more than 20.1mm, and the maximum inhibition zone is 25.01 mm; the oil-control anti-dandruff shampoo has excellent performances in aspects of spreadability, foam richness, wet hair smoothness, dry hair smoothness, oil control effect, anti-dandruff effect, anti-pruritus effect and scalp moisturizing type, is high in evaluation of testers, and has wide development prospects in the field of oil-control anti-dandruff products.
Detailed Description
For the purpose of facilitating an understanding of the present invention, the present invention will now be described by way of examples. It should be understood by those skilled in the art that the examples are only for the understanding of the present invention and should not be construed as the specific limitations of the present invention.
The examples do not show the specific techniques or conditions, according to the technical or conditions described in the literature in the field, or according to the product specifications. The reagents or apparatus used are conventional products commercially available from normal sources, not indicated by the manufacturer.
In the examples of the present invention, zinc pyrithione (48% by mass, 1.25% by mass, 0.25% by mass, 0.4% by mass, and 50.1% by mass of sodium polynaphthalenesulfonate) was obtained from Longsha, Guangzhou, MELALEUCA ALTERNIFOLIA (Melaleuca ALTERNIFOLIA) leaf oil was obtained from Down ender Enterprises International Pty Ltd, and saccharide isomerate (saccharide isomerate) (S) (sugar isomerate)
Sugar isomer 64%, citric acid 0.5%, sodium citrate 0.5% and water 35% by mass) was purchased from DSM Nutritional products Ltd, caprylylglycine was purchased from Satipidae (Shanghai) specialty Chemicals Co., Ltd, and Eucalyptus GLOBULUS (Eucalyptus GLOBULUS) leaf oil was purchased from Robert essence and flavor Co., Ltd.
Example 1
This example provides an oil-control and anti-dandruff composition, which comprises, by mass, 0.2% of zinc pyrithione, 1% of melaleuca alternifolia oil,
12 percent, 1 percent of caprylyl glycine, 3 percent of eucalyptus globulus oil and the balance of water. The preparation method comprises the following steps: proportionally mixing zinc pyrithione, melaleuca alternifolia leaf oil,
And mixing the octanoyl glycine and the eucalyptus globulus leaf oil to obtain the oil-controlling and anti-dandruff composition.
Example 2
This example provides an oil-control and anti-dandruff composition, which comprises, by mass, 0.5% of zinc pyrithione, 6% of melaleuca alternifolia oil,
0.5 percent, 0.1 percent of caprylyl glycine and 5 percent of eucalyptus globulus leaf oil,the balance being water. The preparation method is the same as that of example 1.
Example 3
This example provides an oil-control and anti-dandruff composition, which comprises, by mass, 0.5% of zinc pyrithione, 5% of melaleuca alternifolia oil,
10 percent of caprylyl glycine, 1 percent of eucalyptus globulus oil and 0.3 percent of water in balance. The preparation method is the same as that of example 1.
Example 4
The embodiment provides an oil-control and anti-dandruff composition, which comprises, by mass, 0.2% of zinc pyrithione, 6% of melaleuca alternifolia oil,
0.5 percent, 0.8 percent of caprylyl glycine, 5 percent of eucalyptus globulus oil and the balance of water. The preparation method is the same as that of example 1.
Example 5
The embodiment provides an oil-control and anti-dandruff composition, which comprises, by mass, 0.4% of zinc pyrithione, 0.1% of melaleuca alternifolia oil,
12 percent, 0.1 percent of caprylyl glycine, 3 percent of eucalyptus globulus oil and the balance of water. The preparation method is the same as that of example 1.
Comparative example 1
The difference compared with example 3 is that zinc pyrithione is not included in the oil control and dandruff control composition, and the other is the same as example 3.
Comparative example 2
The difference compared to example 3 is that the oil control and anti-dandruff composition does not comprise melaleuca alternifolia oil, otherwise the same as example 3.
Comparative example 3
Compared to example 3, the only difference is that the oil control and anti-dandruff composition is not included
The rest is the same as in example 3.
Comparative example 4
The difference compared to example 3 is that no capryloyl glycine is included in the oil-control and anti-dandruff composition, and the rest is the same as example 1.
Comparative example 5
The difference compared to example 3 is that eucalyptus globulus oil is not included in the oil control and anti-dandruff composition, and the rest is the same as example 3.
Application example 1
The application example provides an oil-control and anti-dandruff shampoo, and the formula of the oil-control and anti-dandruff shampoo is shown in table 1.
TABLE 1
The preparation method comprises the following steps:
(1) mixing guar hydroxypropyl trimethyl ammonium chloride and water according to a proportion, sequentially adding polyethylene glycol-14M and an anionic surfactant according to a proportion, uniformly stirring, and heating to 85 ℃ to obtain a phase A;
(2) adding the zwitterionic surfactant, the nonionic surfactant, the pearling agent and the suspending agent into the phase A according to the proportion, uniformly stirring, and preserving the heat at 85 ℃ for 25min to obtain a phase B;
(3) cooling the phase B to 75 ℃, adding the oil-controlling and anti-dandruff composition prepared in the example 1, uniformly stirring, and keeping the temperature for 5min to obtain a phase C;
(4) cooling the phase C to 50 ℃, adding sodium isostearoyl lactylate, polydimethylsiloxane and polyquaternium-7 in proportion, and uniformly stirring to obtain a phase D;
(5) adding a preservative, essence and a thickening agent into the phase D in proportion, and adjusting the pH to 5.8 by using a pH regulator to obtain the oil-controlling and anti-dandruff shampoo;
(6) cooling to 37 ℃, filtering and discharging;
(7) and after the inspection is qualified, subpackaging and packaging, and then carrying out secondary inspection and warehousing the finished product.
Application example 2
Compared with the application example 1, the difference is that the oil-controlling and anti-dandruff composition prepared in the example 1 is replaced by the oil-controlling and anti-dandruff composition prepared in the example 2, the mass percent of the oil-controlling and anti-dandruff composition prepared in the example 2 is 16%, and the preparation method of the shampoo comprises the following steps:
(1) mixing guar hydroxypropyl trimethyl ammonium chloride and water according to a proportion, sequentially adding polyethylene glycol-14M and an anionic surfactant according to a proportion, uniformly stirring, and heating to 80 ℃ to obtain a phase A;
(2) adding a zwitterionic surfactant, a nonionic surfactant, a pearling agent and a suspending agent into the phase A, uniformly stirring, and keeping the temperature at 80 ℃ for 25min to obtain a phase B;
(3) cooling the phase B to 70 ℃, adding the oil-controlling and anti-dandruff composition prepared in the example 2, uniformly stirring, and keeping the temperature for 10min to obtain a phase C;
(4) cooling the phase C to 40 ℃, adding sodium isostearoyl lactylate, polydimethylsiloxane and polyquaternium-7 in proportion, and uniformly stirring to obtain a phase D;
(5) adding a preservative, essence and a thickening agent into the phase D in proportion, and adjusting the pH to 6.5 by using a pH regulator (the mass percentage is 0.15%), so as to obtain the oil-control and anti-dandruff shampoo;
(6) cooling to 37 ℃, filtering and discharging;
(7) and after the inspection is qualified, subpackaging and packaging, and then carrying out secondary inspection and warehousing the finished product.
Application example 3
The difference from application example 1 is only that the oil-controlling and anti-dandruff composition prepared in example 1 was replaced with the oil-controlling and anti-dandruff composition prepared in example 3, and the oil-controlling and anti-dandruff composition prepared in example 3 was 15% by mass, and the rest was the same as application example 1.
Application example 4
The difference from application example 1 is only that the oil-controlling and anti-dandruff composition prepared in example 1 was replaced with the oil-controlling and anti-dandruff composition prepared in example 4, and the oil-controlling and anti-dandruff composition prepared in example 4 was 20% by mass, and the rest was the same as application example 1.
Application example 5
The difference from application example 1 is only that the oil-controlling and anti-dandruff composition prepared in example 1 was replaced with the oil-controlling and anti-dandruff composition prepared in example 5, and the oil-controlling and anti-dandruff composition prepared in example 5 was 13% by mass, and the rest was the same as application example 1.
Application comparative example 1
The difference compared to application example 3 is only that the oil-controlling and anti-dandruff composition prepared in application example 3 is removed, and the other is the same as application example 3.
Comparative application example 2
The difference from application example 3 was only that the oil-controlling and anti-dandruff composition prepared in example 3 was replaced with the oil-controlling and anti-dandruff composition prepared in comparative example 1, and the rest was the same as application example 3.
Comparative application example 3
The difference from application example 3 was only that the oil-controlling and anti-dandruff composition prepared in example 3 was replaced with the oil-controlling and anti-dandruff composition prepared in comparative example 2, and the rest was the same as application example 3.
Application comparative example 4
The difference from application example 3 was only that the oil-controlling and anti-dandruff composition prepared in example 3 was replaced with the oil-controlling and anti-dandruff composition prepared in comparative example 3, and the rest was the same as application example 3.
Comparative application example 5
The difference from application example 3 was only that the oil-controlling and anti-dandruff composition prepared in example 3 was replaced with the oil-controlling and anti-dandruff composition prepared in comparative example 4, and the rest was the same as application example 3.
Comparative application example 6
The difference from application example 3 was only that the oil-controlling and anti-dandruff composition prepared in example 3 was replaced with the oil-controlling and anti-dandruff composition prepared in comparative example 5, and the rest was the same as application example 3.
Test example 1 human body patch test
In this test example, the oil-control and dandruff-removing shampoos prepared in application examples 1 to 5 and application comparative examples 1 to 6 were subjected to a human body patch test.
The test was carried out according to the method of the human skin patch test in the technical Specification for safety of cosmetics (2015 edition), and 30 volunteers of 18-60 years old who met the test requirements were selected as the test subjects (15 each for men and women). Adding each sample into a spot tester respectively, wherein the dosage is 0.020-0.025 g, no substance is added to a blank control, the spot tester is pasted on the bent side of the forearm of a subject by using a non-irritating adhesive tape, the forearm is lightly pressed by a palm to be uniformly pasted on the skin, the test part is marked for observation and is pasted for 24 hours, the adverse reaction grade of the skin is shown in table 2 after 0.5 hour, 24 hours and 48 hours after the patch is uncovered, and the test result is shown in table 3.
TABLE 2
TABLE 3
As shown in Table 3, when the shampoo of examples 1-5 was added with the oil-controlling and anti-dandruff composition prepared in examples 1-5, no adverse skin reaction occurred in the subjects, and the results were comparable to the blank control and the subjects who did not have the oil-controlling and anti-dandruff composition prepared in examples 1-5The application of the oil control and anti-dandruff composition is the same as in comparative example 1, which shows that the oil control and anti-dandruff composition is not irritating to the skin; the shampoo of comparative examples 2-6 is added with the oil-controlling and anti-dandruff composition of comparative examples 1-5, without simultaneously adopting zinc pyrithione, melaleuca alternifolia oil,
1 cases of first-level adverse reactions of the capryloyl glycine and the eucalyptus globulus leaf oil occur, a certain degree of irritation exists, and when the oil-controlling and anti-dandruff composition is not added in the comparative example 1, adverse reactions of skin do not occur in a subject; the oil-control and anti-dandruff composition of the invention combines the zinc pyrithione, the melaleuca alternifolia oil,
The caprylyl glycine and the eucalyptus globulus oil are synergistic, so that adverse reactions of skin can be avoided, and the shampoo containing the oil-controlling and anti-dandruff composition is mild and non-irritating.
Test example 2 bacteriostatic effect test
In the test example, the bacteriostatic ring test of malassezia furfur is carried out by referring to the operation method of the drug sensitivity test of the American clinical laboratory standards Committee and applying the oil-control and anti-dandruff shampoos prepared in application examples 1-5 and application comparative examples 1-6.
Testing strains: malassezia furfur.
The main apparatus is as follows: constant temperature incubator, superclean bench, hole puncher, liquid-transfering gun, tweezers and sterilization flat board.
The experimental process comprises the following steps:
(1) preparing malassezia furfur into a bacterial suspension;
(2) uniformly coating the mixture on a Leeming and Notman culture medium flat plate, and then placing the flat plate in a sterile operating platform to blow dry bacterial liquid on the flat plate;
(3) quantitatively adding each sample into the plate, culturing in a 30 ℃ constant temperature incubator for 48h to observe results, recording and measuring the bacteriostatic ring condition, performing three tests on each sample to be tested in parallel, and averaging the results as shown in table 4.
TABLE 4
As can be seen from Table 4, the diameters of inhibition zones of the oil-control and anti-dandruff shampoo prepared by the application examples 1-5 are all higher than 20.1mm and the maximum diameter is 25.01mm, and the oil-control and anti-dandruff shampoo has an efficient effect of inhibiting malassezia furfur; the application comparison example 1 does not add the oil-control anti-dandruff composition, the application comparison example 2 adopts the oil-control anti-dandruff composition without the zinc pyrithione, the bacteriostatic diameter of the oil-control anti-dandruff composition is only 1.2mm and 2.2mm, the bacteriostatic effect is poor, and the application comparison examples 3-6 adopt the oil which lacks the interbody leaf cajeput oil,
The oil-controlling and anti-dandruff composition of the caprylyl glycine or the eucalyptus globulus leaf oil has the bacteriostatic diameter lower than 19.3mm and the lowest value of 14.3mm, and has poor bacteriostatic effect; the oil control and anti-dandruff composition disclosed by the invention has the advantages that the components are synergistic, the antibacterial effect is improved, and the oil control and anti-dandruff shampoo containing the oil control and anti-dandruff composition has a high-efficiency antibacterial effect.
Test example 3 Corrosion protection challenge test
The oil-controlling and anti-dandruff shampoos prepared in application examples 1 to 5 and application comparative examples 1 to 6 were subjected to a preservation challenge test in accordance with the method in the european pharmacopoeia (EP7.0) to simulate microbial contamination during the production and use of cosmetics.
The strains used include: the bacteria are staphylococcus aureus ATCC 6538, pseudomonas aeruginosa ATCC9027 and escherichia coli ATCC 8739; the yeast is Candida albicans ATCC 10231; the mold is Aspergillus niger ATCC 16404.
The experimental process comprises the following steps:
(1) preparing a bacterial suspension: adjusting the bacteria suspension concentration to about 10 by using a turbidimetric method9cfu/mL, adjusting the bacterial liquid concentration of the yeast suspension to about 109cfu/mL, the bacterial liquid concentration of the mold suspension is adjusted to about 10 by adopting a blood counting method7cfu/mL, and calculating the concentration of each bacterial suspension by adopting a plate counting method to serve as the initial bacterial concentration of the inoculated sample;
(2) inoculation: respectively weighing 20g of sample to be tested, adding into 3 sterilized 30mL plastic bottles, and adding 0.2mL of each of the bacterial suspension, yeast suspension and mold suspension to obtain an initial concentration of 6.6 × 107cfu/g, initial concentration of yeast 2.5X 105cfu/g, initial concentration of mold 2.0X 107cfu/g, fully and uniformly mixing, and culturing at 28 +/-1 ℃;
(3) the bacterial concentrations were counted by plate counting on days 7, 14, 21 and 28 of the culture, respectively, and the results are shown in Table 5.
TABLE 5
As can be seen from Table 5, the bacteria concentration of the shampoo for controlling oil and removing dandruff is still lower than 10cfu/g after the shampoo for controlling oil and removing dandruff is inoculated with microorganisms for 28 days, and the shampoo for controlling oil and removing dandruff has higher safety.
Test example 4 sensory evaluation of human body
The various effects of the oil-controlling and dandruff-removing shampoos prepared in application examples 1-5 and application comparative examples 1-6 were analyzed by human sensory evaluation tests.
240 volunteers are recruited and divided into 12 groups randomly, each group of volunteers continuously uses each group of shampoo for 8 weeks to perform a half-head comparison test, the commercially available oil-control and anti-dandruff shampoo is taken as a control group, the back visit of the tested effect is performed every 2 weeks, the testers score according to the use experience, the scoring standard adopts 9 points, the corresponding effect is 1 point as low as 1 point, the corresponding effect is 3 points as low as 3 points, the corresponding effect is generally 5 points as high as 7 points, the corresponding effect is 9 points as high as 9 points, the score can be accurate to 1 point, and the final result is the average value of all data, as shown in table 6.
TABLE 6
As can be seen from table 6, the oil-controlling and anti-dandruff shampoo of examples 1 to 5 has high scores for each effect, namely, the lowest score is 5.5 and the highest score is 7.9, and the overall score is also high, namely, higher than 6.6 and the highest score is 7.9, so that the aspects of foam richness, wet hair smoothness, dry hair smoothness, oil-controlling effect, anti-dandruff effect and the like are favored by testers. Compared with the prior art, the application comparative example 1 is the oil-control and anti-dandruff composition without adding oil, the application comparative examples 2 to 6 are the oil-control and anti-dandruff composition without certain components, and the shampoo sold in the market has lower overall score which is lower than 6.1 and is as low as 3.6, although the application comparative examples in part are excellent in terms of foam richness, wet hair smoothness and dry hair smoothness, but are poorer in terms of oil control effect, anti-dandruff effect, anti-pruritus effect and scalp moisture retention than the application examples 1 to 5, which shows that the components in the oil-control and anti-dandruff composition have synergistic effect, so that the oil control effect, the anti-dandruff effect, the anti-pruritus effect and the moisture retention of scalp can be obviously improved, and the shampoo containing the oil-control and anti-dandruff composition has excellent effects and higher evaluation of testers.
In conclusion, the anti-dandruff composition disclosed by the invention simultaneously adopts zinc pyrithione, melaleuca alternifolia oil, saccharide isomerate, caprylyl glycine and eucalyptus globulus oil, all the components are synergistic, the oil control effect, the anti-dandruff effect, the anti-pruritus effect and the moisture retention of scalp can be obviously improved, the irritation is low, and the shampoo containing the oil control anti-dandruff composition has excellent effects in all aspects, is higher in evaluation of testers, and has a wide application prospect in the field of oil control anti-dandruff products.
The applicant states that the present invention is illustrated by the above examples to show the detailed process equipment and process flow of the present invention, but the present invention is not limited to the above detailed process equipment and process flow, i.e. it does not mean that the present invention must rely on the above detailed process equipment and process flow to be implemented. It should be understood by those skilled in the art that any modification of the present invention, equivalent substitutions of the raw materials of the product of the present invention, addition of auxiliary components, selection of specific modes, etc., are within the scope and disclosure of the present invention.
Claims (10)
1. An oil-controlling and anti-dandruff composition, which is characterized by comprising zinc pyrithione, melaleuca alternifolia oil, saccharide isomers, caprylylglycine and eucalyptus globulus oil.
2. The oil-controlling and anti-dandruff composition according to claim 1, wherein the mass ratio of zinc pyrithione, melaleuca alternifolia oil, saccharide isomerate, caprylylglycine and eucalyptus globulus oil is (0.2-0.5): (0.1-6): (0.5-12): (0.1-1): (0.3-5).
3. The oil-control and anti-dandruff composition according to claim 1 or 2, wherein the mass percentage of the zinc pyrithione in the oil-control and anti-dandruff composition is 0.2-0.5%;
preferably, the weight percentage of the melaleuca alternifolia oil in the oil-controlling and anti-dandruff composition is 0.1-6%;
preferably, the mass percentage of the saccharide isomer in the oil-controlling and anti-dandruff composition is 0.5-12%;
preferably, the mass percentage of the caprylyl glycine in the oil-control and anti-dandruff composition is 0.1% -1.0%;
preferably, the mass percentage of the eucalyptus globulus oil in the oil-controlling and anti-dandruff composition is 0.3% -5%.
4. Root of herbaceous plantThe oil-control and dandruff-control composition according to any of claims 1 to 3, wherein the saccharide isomers comprise
Preferably, the oil-control and anti-dandruff composition further comprises water;
preferably, the mass percentage of the water in the oil-controlling and anti-dandruff composition is 76-90%.
5. The oil-control and anti-dandruff composition according to any one of claims 1 to 4, wherein the oil-control and anti-dandruff composition comprises, by mass percent, 0.2 to 0.5% of zinc pyrithione, 0.1 to 6% of melaleuca alternifolia oil, 0.5 to 12% of saccharide isomers, 0.1 to 1.0% of caprylyl glycine, 0.3 to 5% of eucalyptus globulus oil, and the balance of water;
preferably, the oil-control and anti-dandruff composition comprises, by mass, 0.2-0.5% of zinc pyrithione, 0.1-6% of melaleuca alternifolia oil,
0.5 to 12 percent of the total weight of the composition, 0.1 to 1.0 percent of caprylyl glycine, 0.3 to 5 percent of eucalyptus globulus leaf oil and the balance of water.
6. Use of an oil-controlling and anti-dandruff composition according to any one of claims 1 to 5 for the preparation of an oil-controlling and anti-dandruff cosmetic;
preferably, the formulation of the oil-controlling and dandruff-removing cosmetic comprises any one of shampoo, hair conditioner or scalp care solution, and is preferably shampoo.
7. An oil-control and anti-dandruff shampoo, characterized in that the oil-control and anti-dandruff shampoo comprises the oil-control and anti-dandruff composition according to any one of claims 1 to 5;
preferably, the oil-controlling and dandruff-removing composition accounts for 13 to 20 percent of the weight of the oil-controlling and dandruff-removing shampoo;
preferably, the oil-control and anti-dandruff shampoo further comprises an anionic surfactant, a nonionic surfactant, a zwitterionic surfactant, a conditioning agent, a preservative, essence, a suspending agent, a pearling agent, a thickening agent, a pH regulator and water;
preferably, the anionic surfactant comprises sodium laureth sulfate;
preferably, the nonionic surfactant comprises any one of or a combination of at least two of cocamide MEA, cocamide methyl MEA, or decyl glucoside;
preferably, the zwitterionic surfactant comprises cocamidopropyl betaine;
preferably, the conditioning agent comprises any one of guar hydroxypropyl trimethyl ammonium chloride, polyethylene glycol-14M, sodium isostearoyl lactylate, polydimethylsiloxane or polyquaternium-7 or a combination of at least two of the two;
preferably, the preservative comprises phenoxyethanol and/or potassium sorbate;
preferably, the suspending agent comprises trihydroxystearin;
preferably, the pearlescent agent comprises ethylene glycol distearate;
preferably, the thickener comprises sodium chloride;
preferably, the pH adjusting agent comprises citric acid and/or sodium citrate.
8. The preparation method of the oil-control and anti-dandruff shampoo as claimed in claim 7, wherein the preparation method comprises the following steps:
(1) mixing guar hydroxypropyl trimethyl ammonium chloride with water, sequentially adding polyethylene glycol-14M and anionic surfactant, mixing, and heating to obtain phase A;
(2) adding a zwitterionic surfactant, a nonionic surfactant, a pearling agent and a suspending agent into the phase A, mixing and preserving heat to obtain a phase B;
(3) cooling the phase B, adding the oil-controlling and anti-dandruff composition according to any one of claims 1 to 5, mixing and keeping the temperature to obtain a phase C;
(4) cooling the phase C, adding sodium isostearoyl lactylate, polydimethylsiloxane and polyquaternium-7, and mixing to obtain phase D;
(5) and adding a preservative, essence and a thickening agent into the phase D, and adjusting the pH by using a pH regulator to obtain the oil-controlling and anti-dandruff shampoo.
9. The method for preparing the oil-control and dandruff-removal shampoo as claimed in claim 8, wherein the temperature in the step (1) is raised to 80-85 ℃;
preferably, the temperature of the heat preservation in the step (2) is 80-85 ℃;
preferably, the heat preservation time in the step (2) is 25-35 min;
preferably, the temperature of the temperature reduction treatment in the step (3) is 70-75 ℃;
preferably, the heat preservation time in the step (3) is 5-10 min;
preferably, the temperature of the temperature reduction treatment in the step (4) is 40-50 ℃;
preferably, the pH value in the step (5) is 5.0-6.5.
10. Method for preparing an oil-control and dandruff-control shampoo according to claim 8 or 9, characterized in that it comprises the following steps:
(1) mixing guar gum hydroxypropyl trimethyl ammonium chloride with water, sequentially adding polyethylene glycol-14M and an anionic surfactant, mixing, and heating to 80-85 ℃ to obtain a phase A;
(2) adding a zwitterionic surfactant, a nonionic surfactant, a pearling agent and a suspending agent into the phase A, mixing, and keeping the temperature at 80-85 ℃ for 25-35 min to obtain a phase B;
(3) cooling the phase B to 70-75 ℃, adding the oil-controlling and anti-dandruff composition of any one of claims 1-5, mixing and keeping the temperature for 5-10 min to obtain a phase C;
(4) cooling the phase C to 40-50 ℃, adding sodium isostearoyl lactylate, polydimethylsiloxane and polyquaternium-7, and mixing to obtain a phase D;
(5) and adding a preservative, essence and a thickening agent into the phase D, and adjusting the pH to 5.0-6.5 by using a pH regulator to obtain the oil-control and anti-dandruff shampoo.
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| CN114366702A (en) * | 2022-01-28 | 2022-04-19 | 珠海博御中医药研究有限公司 | Shampoo with dandruff removing, itching relieving and oil control effects and preparation method thereof |
| CN115721593A (en) * | 2022-12-16 | 2023-03-03 | 广州科堡化妆品有限公司 | Hair mask beneficial to removing peculiar smell and smoothing hair |
| CN116196243A (en) * | 2023-01-17 | 2023-06-02 | 广州宝仪生物科技有限公司 | Vegetable oil-control and dandruff-removing composition and preparation method thereof |
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Address after: 510663 No.15, Kelin Road, Guangzhou Science City, Guangzhou high tech Industrial Development Zone, Guangdong Province Applicant after: Guangzhou Huanya cosmetics technology Co.,Ltd. Address before: 510663 No.15, Kelin Road, Guangzhou Science City, Guangzhou high tech Industrial Development Zone, Guangdong Province Applicant before: GUANGZHOU HUANYA COSMETICS TECHNOLOGY Co.,Ltd. |
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