CN105997596A - Dandruff removing composition containing plant essential oil having synergistic effect and application thereof - Google Patents
Dandruff removing composition containing plant essential oil having synergistic effect and application thereof Download PDFInfo
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- CN105997596A CN105997596A CN201610542801.XA CN201610542801A CN105997596A CN 105997596 A CN105997596 A CN 105997596A CN 201610542801 A CN201610542801 A CN 201610542801A CN 105997596 A CN105997596 A CN 105997596A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/006—Antidandruff preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/02—Preparations for cleaning the hair
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/12—Preparations containing hair conditioners
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Abstract
The invention relates to a dandruff removing composition containing plant essential oil having a synergistic effect and application of the composition in hair washing and care products. The dandruff removing composition is prepared from, by weight, zinc pyrithione 2.0-20.0%, plant essential oil composition 5.0-15.0%, a suspending agent 0.3-2.0% and water and/or alcohol 63.0-92.7%, wherein the plant essential oil composition and the zinc pyrithione have the antibacterial and dandruff removing synergistic effect. The invention further relates to application of the dandruff composition in liquid shampoo and hair conditioners.
Description
Technical field
The invention belongs to cosmetics of everyday use field, relate to desquamation compositions and the application thereof of a kind of plants essential oil potentiation, specifically
Relate to a kind of with Zinc Pyrithione and the desquamation compositions of plants essential oil Synergistic and application.
Background technology
Dandruff problem usually perplexs the various aspects such as the work of people, life and social activity.Pathologic dandruff may the cycle
Property, recurrently occur, can arrive time serious and cause scalp hair follicles impaired, formed permanent alopecia.Pathologic dandruff is generally recognized
For being that fungus amount reproduction on scalp of a kind of chlosma (Malassezia) causes the cuticular hyperplasia of scalp, from
And promote corneocyte extremely to come off with the form of white or Lycoperdon polymorphum Vitt squama, i.e. form dandruff.This kind causes the horse traction color of dandruff
Bacterium is unit cell yeast, also referred to as pityrosporum furfur.Chlosma does not has independent activeness, and it is taken the photograph from sebaceous gland lipid
Take fatty acid and survive, after consuming the satisfied fatty acid that the triglyceride in sebum decomposes out, remaining unsaturated fatty acids
Acid then infiltrates through scalp, causes the inflammatory reaction of human body.When inflammatory reaction occurs, scalp cells proliferative disorder accelerates, cutin
The scalp physiological structure abnormal phenomenas such as cellular keratinization cutin tunicle incomplete, abnormal, ultimately resulting in cells of superficial layer large area comes off,
Form dandruff.Suppression sebum secretion and employing antifungal are all effective anti-dandruff approach theoretically；Practice is generally selected
Selecting effective Active antifungal compound, people have been developed that the highly active antifungal activity that minimal inhibitory concentration is 1-30ppm
Thing, including selenium sulfide, Zinc Pyrithione (ZPT), ketoconazole (Ketoconazole), climbazole (Climbazole) and pyridone
Ethanolamine (OCT), hexamidine two (ethoxy) sulfonate, undecylenic derivatives etc..Wherein Zinc Pyrithione has and well goes
Bits effect, conventional amount used are to human non-toxic's side effect, moderate cost, the first-selection of the most anti-dandruff product.But due to the anti-dandruff product of ZPT
Product degreasing power is strong, and commonly used destruction scalp stratum corneum barrier easily causes the ill effects such as hair is dry and astringent, and ZPT exists
Environment can not be degraded, and exist hydrobiological hazardness.So also needing to formula improves ZPT activation method, with fall
Low ZPT consumption and reach similar anti-dandruff effect and alleviate ZPT side effect.
The sterilizing mechanisms of ZPT is its lipotropy and chelation.Therefore active component can effectively be carried to the end by exploitation
The physical support in epidermis face, and active component is dissolved in sebum effectively for the chemical activation body of chlosma absorption by exploitation
System, becomes and washes the important technology innovative point protecting formula for a product.
Quintessence oil is the secondary metabolites of plant, is that a class can have certain aromatic odor and can be often with vapor distillation
The general name of the oily mater of the lower volatilization of temperature.Many studies have shown that plants essential oil has suppression antibacterial, fungus and the work of pest and disease damage
With.Quintessence oil comes from natural, has good environment compatibility, and this makes it become the new resources of exploitation antibacterial.Plant essence
Oil, by affecting cell membrane normal function, result in cell membrane function and is affected, and cellular content leaks, and ultimately results in antibacterial
Dead；Or affect energy metabolism and reductase system, and then cause the metabolic system disorder of microorganism.Current study show that plant
Quintessence oil does not contain only effective antifungal active component, and the bacteriostatic active ingredients such as thymol can also suppress S.epidermidi
Deng the potentially pathogenic organism affecting scalp microecological environment.Additionally, various plants quintessence oil is in the news and has antiinflammation, may subtract
The serious pathologic dandruff aspect that slow pityrosporum folliculitis causes has medical value.Therefore, plants essential oil is by changing
Kind scalp microecological environment, repairs impaired stratum corneum barrier and reaches lasting anti-dandruff effect.But the chemical composition in plants essential oil is multiple
Miscellaneous various, and the compound really with bacteriostasis can be solely one of which or several, also likely to be present between each compound
Complicated antagonism or potentiation.This is accomplished by according to using target, according to the composition principle of Chinese medicine monarch or
" to medicine " complementary principle, is analyzed plants essential oil component and effect and combines rightly, to reach Synergistic
Effect.
On the basis of above research invention, plant essential oil composition is used for the exploitation of anti-dandruff product by the present invention, finds
There is Synergistic and commonly use the antibacterial anti-dandruff effect of anti-dandruff agent Zinc Pyrithione.
Summary of the invention
A kind of desquamation compositions, its feature at component and the content of compositions is: Zinc Pyrithione percentage by weight is
2.0-20.0%；Plant essential oil composition percentage by weight is 5.0-15.0%；Suspension dispersive agent percentage by weight is 0.3-
2.0%；Water is or/and alcohol weight ratio 63.0-92.7%.
Described plant essential oil composition be cupressus sempervirens (Cupressus sempervirens) quintessence oil (cypress quintessence oil),
Rhizoma Zingiberis Recens (Zingiber officinale) quintessence oil, Herba thymi vulgaris (Thymusmongolicus) quintessence oil, Herba Menthae (Mentha
Piperita) quintessence oil, cubeb litsen tree (Litsea cubeba) fruit oil, Herba Rosmarini Officinalis (Rosmarinus officinalis) quintessence oil, smoke
Clothing grass (Lavandula officinalis) quintessence oil, Cortex Cinnamomi (Cinnamomum zeylanicum) quintessence oil, Eucalyptus globulus Labill
(Eucalyptus globulus) leaf essential oil (eucalyptus quintessence oil), Flos Caryophylli (Eugenia caryophyllus) quintessence oil, Juniperus communis
(Juniperus communis) fruit oil (Juniperus rigida Sieb.et Zucc. quintessence oil) and Melaleuca alternifolia (Melaleuca alternifolia) quintessence oil
The specific combination of (tea tree ethereal oil).
Described plant essential oil composition is cupressus sempervirens (Cupressus sempervirens) quintessence oil (cypress quintessence oil)
Compositions with lavandula angustifolia (Lavandula officinalis) quintessence oil volume ratio 1:100-5:1.
Described plant essential oil composition is Eucalyptus globulus Labill (Eucalyptus globulus) leaf essential oil (eucalyptus quintessence oil), alternate
Leaf Cortex Melaleucae leucadendrae (Melaleuca alternifolia) quintessence oil (tea tree ethereal oil) and lavandula angustifolia (Lavandula officinalis)
The compositions of quintessence oil volume ratio 2:5:3-1:7:2.
Described plants essential oil is Herba Rosmarini Officinalis (Rosmarinus officinalis) quintessence oil, cubeb litsen tree (Litsea
Cubeba) fruit oil, Herba Menthae (Mentha piperita) quintessence oil and Juniperus communis (Juniperus communis) fruit oil volume ratio 2:
The compositions of 1:6:1-6:1:2:1.
Described plants essential oil is Herba thymi vulgaris (Thymus mongolicus) quintessence oil, Cinnamomum zeylanicum Bl. (Cinnamomum
Zeylanicum) quintessence oil, Rhizoma Zingiberis Recens (Zingiber officinale) quintessence oil, Flos Caryophylli (Eugenia caryophyllus) quintessence oil
The compositions of volume ratio 1:4:4:1-5:2:2:1.
Described plants essential oil is Herba Pogostemonis (Pogostemon cablin) quintessence oil, medicine Salvia japonica Thunb. (Salvia
Officinalis) quintessence oil, Adeps Bovis seu Bubali (Origanum vulgare) quintessence oil, Radix Cymbopogonis Citrati (Cymbopogon citratus) essence
Oil, the compositions of Radix Artemisia ordosicae (Artemisia afra) quintessence oil volume ratio 1:1:1:1:1-4:2:2:1:1.
Described suspending agent elect as Lithium metasilicate magnesium, Magnesiumaluminumsilicate any one.
Described desquamation compositions is in the application preparing anti-dandruff type shampoo, hair conditioner is washed in hair products.
Described desquamation compositions 0.5-2.0% by weight percentage in shampoo adds, at hair conditioner percentage by weight
Add than for 0.2-1.0%.
The beneficial effect of the invention
The primary advantage of anti-dandruff synergistic composition of the present invention be add relatively low-dose Zinc Pyrithione up to
To the anti-dandruff effect that high dose is same, it is minimum that the minimum additive capacity of desquamation compositions and the highest addition are converted into Zinc Pyrithione
Final concentration of 0.004% (W/W) and the highest final concentration of 0.4% (W/W), i.e. can reach Zinc Pyrithione final concentration 1.0% (W/
W) identical anti-dandruff effect, alleviates Zinc Pyrithione and causes the dry and astringent counter productive of defat and draw the hypotoxicity of aquatic organism
The destructiveness of the aquatic environment risen；And essential oil composition dosage commercialization essential oil composition on year-on-year basis(U.S. Bio-
The patented product of Botanica, by Adeps Bovis seu Bubali (Origanum vulgare), narrow-leaved lavender (Lavandula
Officinalis), Herba Rosmarini Officinalis (Rosmarinus officinalis), Cinnamomum zeylanicum Bl. (Cinnamomum zeylanicum) with
And goldenseal (Hydrastis canadensis) quintessence oil compounds) effective antibacterial decrease in dose 15 times, i.e. anti-dandruff with compounding
In compositions, the minimum antibacterial anti-dandruff dosage 0.01% (W/W) of plant essential oil composition is that known effective plants essential oil is antibacterial
Compositions/ 15th of minimum effective antibacterial dosage (0.15%W/W), the most also has and reduces cost
Advantage.
The meaning of Zinc Pyrithione and plants essential oil desquamation compositions also resides in and can obtain instant anti-dandruff effect, and
Owing to different plant essential oil compositions are suitable for different scalp condition (oiliness, dryness and struvite), contribute to regulating oils and fats
Secretion, improves scalp microenvironment, maintenance scalp stratum corneum barrier.Therefore, after treatment cycle, disable two weeks, remain to keep strong
The scalp condition of health, it is to avoid dandruff occurs repeatedly.
The detailed description of invention
Zinc Pyrithione of the present invention is heterocyclic compound, and molecular formula is C10H8N2O2S2Zn, chemical name is double (1-
Hydroxyl-2 (1H) pyridine-O, S) zinc, structural formula is as follows:
Zinc Pyrithione of the present invention can be that be bestowed by heaven company, Guangzhou of Qi company of Austria of the U.S., Guangzhou flies auspicious chemical industry and Shan
Head tide emblem chemical products.
Plant essential oil composition of the present invention is the plants essential oil cupressus sempervirens with notable antibacterial action
(Cupressus sempervirens) quintessence oil (cypress quintessence oil), Rhizoma Zingiberis Recens (Zingiber officinale) quintessence oil, Herba thymi vulgaris
(Thymus mongolicus) quintessence oil, Herba Menthae (Mentha piperita) quintessence oil, cubeb litsen tree (Litsea cubeba) fruit oil,
Herba Rosmarini Officinalis (Rosmarinus officinalis) quintessence oil, lavandula angustifolia (Lavandula officinalis) quintessence oil, Cortex Cinnamomi
(Cinnamomum zeylanicum) quintessence oil, Eucalyptus globulus Labill (Eucalyptus globulus) leaf essential oil (eucalyptus quintessence oil), Flos Caryophylli
(Eugenia caryophyllus) quintessence oil, Juniperus communis (Juniperus communis) fruit oil (Juniperus rigida Sieb.et Zucc. quintessence oil) and alternate leaf are white
The combination in any of thousand layers (Melaleuca alternifolia) quintessence oil (tea tree ethereal oils).These plants essential oils or antibacterial,
Or antiinflammation or conciliation fat secretion effect are the most at home or external academic journal is reported.
Plant essential oil composition of the present invention is cupressus sempervirens (Cupressus sempervirens) quintessence oil (cypress
Quintessence oil) and the compositions of lavandula angustifolia (Lavandula officinalis) quintessence oil mass ratio 1:100-5:1.Described Cupressus semperviren
Wood (Cupressus sempervirens) quintessence oil, also referred to as cypress quintessence oil, main Antibacterial Constituents be terpineol, cedrol,
Cedrus deoclar (Roxb.) G. Don Camphora；There is regulation fat secretion, tighten pore effect；The main chemical compositions of Herba Lysimachiae foenum-graeci quintessence oil is linalool, acetic acid
Lignum cinnamomi camphorae ester, not only inhibited but also there is anti-inflammatory anti-itch effect to pathogenic bacterium；Preferably narrow-leaved lavender quintessence oil, it is antibacterial
The phenol coefficient of effect is higher.This essential oil composition is suitable for most dandruff patient, is especially suitable for mild or moderate dandruff patient.
Plant essential oil composition of the present invention is Eucalyptus globulus Labill (Eucalyptus globulus) leaf essential oil (eucalyptus globolus essence
Oil), Melaleuca alternifolia (Melaleuca alternifolia) quintessence oil (tea tree ethereal oil) and lavandula angustifolia (Lavandula
Officinalis) compositions of quintessence oil volume ratio 2:5:3-1:7:2.Eucalyptus globulus Labill (Eucalyptus globulus) leaf essential oil also known as
For eucalyptus quintessence oil, main Antibacterial Constituents is eucalyptol, Lignum cinnamomi camphorae alkene, Camphora, fenchene, Fructus Citri grandis eleoptene, has the most pre-
The effect of inflammation that bacteriological protection, fungus grow and cause；Melaleuca alternifolia (Melaleuca alternifolia) quintessence oil leads to
Be frequently referred to tea tree ethereal oil, have bactericidal antiphlogistic, convergence pore effect, main active be γ-terpinene, sobrerone, limonene,
Cineol, terpineol, fenchene.This essential oil composition is suitable for most dandruff patient, is especially suitable for oiliness scalp dandruff patient.
Plants essential oil of the present invention is Herba Rosmarini Officinalis (Rosmarinus officinalis) quintessence oil, cubeb litsen tree (Litsea
Cubeba) fruit oil, Herba Menthae (Mentha piperita) quintessence oil and Juniperus communis (Juniperus communis) fruit oil volume ratio 2:
The compositions of 1:6:1-6:1:2:1.Herba Rosmarini Officinalis (Rosmarinus officinalis) quintessence oil has stronger astriction, adjusts
Managing greasy unclean skin, blood circulation promoting, stimulating hair regenerates；Its main active is australene, Camphora, Herba Verbenae
Ketone；Cubeb litsen tree (Litsea cubeba) fruit oil is also called Fructus Litseae essential oil, Fructus Linderae Glaucae quintessence oil, is produced in China Guangdong, Fujian one
Band, has and all has the other antibacterial activity of sensitivity level to aspergillus niger, yeast and staphylococcus, and its main antimicrobial component is Fructus Citri Limoniae
Aldehyde, cubeb litsen tree quintessence oil also has regulation fat secretion effect；And Herba Menthae (Mentha piperita) quintessence oil, main chemical compositions
Menthol, menthone, eucalyptole, methyl acetate, methyl ethanol furan, limonene, sobrerone or pinene, sabinene hydroxide and
Pulegone, can treat dermatitis, acne, ringworm, scabies and pruritus, has the curative effect of prevention sunburn, has refrigerant skin simultaneously
Effect；Juniperus communis (Juniperus communis) fruit oil is the volatile oil that male likes, has antiinflammatory, pressure of releiving work
With.This essential oil composition is especially suitable for the dandruff patient that the Nervous and Mental Factors such as pressure is big cause and uses and oiliness dandruff patient makes summer
With.
Plants essential oil of the present invention is Herba thymi vulgaris (Thymus mongolicus) quintessence oil, Cinnamomum zeylanicum Bl. (Cinnamomum
Zeylanicum) quintessence oil, Rhizoma Zingiberis Recens (Zingiber officinale) quintessence oil, Flos Caryophylli (Eugenia caryophyllus) quintessence oil
The compositions of volume ratio 1:4:4:1-5:2:2:1.The active component thymol of thyme oil is typical bactericidal virtue
Potential pathogenic bacterium in the scalp Tiny ecosystem such as staphylococcus epidermidis are had preferable antibacterial effect by aroma compounds component.Cortex Cinnamomi
(Cinnamomum zeylanicum) quintessence oil main component cinnamic aldehyde (98.2%), secondly be α-phellandrene, 1,8-eucalyptus oil
Element, paracymene, Camphora, linalool, β-caryophyllene, α-Ylangene, alpha-terpineol, geraniol, acid methylester, ethyl cinnamate,
Eugenol, cinnamyl alcohol etc., be current research report antifungal and the strongest plants essential oil of antibacterial actions；And cinnamon essential oil
Warm in nature, expand peripheral vessel, blood circulation promoting.In like manner ginger essential oil also has the logical effect of moderate antibacterial and temperature.Fourth
Essential oil main active eugenol so that it is not only antiinflammatory, periodontitis pathogenic bacterium (Botrytis cinerea
Prevotella intermedia, Prevotella melaninogenica, Pophyromonas gingivalis) effect
Good, and there is blood circulation promoting, the effect of pleasant mental and body；It regulates scalp microenvironment, the effect of suppression inflammatory reaction.
This essential oil composition is especially suitable for dry scalp dandruff patient or seasonality dandruff patient autumn and winter.
Herba Pogostemonis (Pogostemon cablin) quintessence oil effective antimicrobial component patchouli alcohol, benzaldehyde, cinnamic aldehyde, fourth
Fragrant phenol, has the antibacterial and anti-inflammation functions of wide spectrum, is helping regenerative cell, improves coarse skin, acne, the leakage of scalp fat and eczema
Deng obvious effect in reparation skin keratin barrier.Adeps Bovis seu Bubali (Origanum vulgare) quintessence oil main Antibacterial Constituents carvacrol
And thymol, it is the most potent natural anti-inflammatory antibacterial that have now been found that of the mankind；Salvia japonica Thunb. (Salvia officinalis) essence
Oil main chemical compositions: α-absinthol, β-absinthol, 1, 8-Cineole, Camphora, Herba Origani Vulgaris quintessence oil and Herba Salviae Japonicae essential oil are equal planting
Thing, is antibacterial.Radix Cymbopogonis Citrati (Cymbopogon citratus) the main bacteriostatic active ingredients of quintessence oil is citral, is suitable for oil
Property and mixed skin, regulate fat secretion, antibacterial and deodorization functions；Also it is the virtue treatment class quintessence oil releived pressure with improve spirit
Choosing.The main antimicrobial component of Radix Artemisia ordosicae (Artemisia afra) quintessence oil is cineole, Camphora, Borneolum Syntheticum, piperitol etc., cures mainly
Effect, blood of regulating the flow of vital energy, warming the meridian arteries and veins, dispelling cold and dampness, pain relieving, antibacterial, antiinflammatory, promote circulation, promote immunity.This essential oil composition is suitable for many
Number dandruff patients, particularly cause the impaired serious dandruff patient of stratum corneum barrier because of dandruff.
Plants essential oil of the present invention is that plant specific part uses steam distillation, shrinkage squeezing or CO2Supercritical
Quintessence oil prepared by any one method in extraction；Feature according to described quintessence oil uses optimal industrial extraction method,
Not destroy the original active component of plants essential oil and not increase the solvent of other side effect and be preferred.
Suspending agent of the present invention be selected from Lithium metasilicate magnesium, Magnesiumaluminumsilicate any one, such as Rheox company
Bentone series, VeegumPRO series；Not only compositions is had suspension thickening power, the most within the specific limits oils and fats is had
There is stable emulsifying effect.
Dandruff control shampoo containing of the present invention is shampoo conventional formulation, except going containing described in percentage by weight 0.5-2.0%
Bits compositions, also include following according to percentage by weight add component: anion surfactant 10-25%, amphoteric surface
Activating agent/nonionic surfactant 2-10%, cation opsonizing agent 1.0-5.0%, emulsified silicone oil 0-3.0%, pearling agent 0-
2.0%, thickening agent 0.3-5.0%, preservative, essence are appropriate；Pay special attention in formula without metal ion-chelants such as EDTA
Agent.
Anti-dandruff hair conditioner of the present invention is conventional formulation, except the described anti-dandruff combination containing percentage by weight 0.2-1.0%
Thing, also include following according to percentage by weight add component: C16/C18/C22 alkyl trimethyl ammonium chloride/bis-h-tallow
Aliphatic radical alkyl dimethyl ammonium chloride/stearylbenzyidimethylammonium ammonium chloride 0.8-1.5%, C16/C18 alcohol 2.0-15%, emulsified silicone oil 0-
3.0%, glyceryl monostearate 0-0.6%, C16 alkyl (EO) 20 ether 0-0.5%；Thickening agent 0-2.0%, preservative, essence
In right amount；Pay special attention in formula without metal ion chelation agents such as EDTA.
The meaning of Zinc Pyrithione and plants essential oil desquamation compositions also resides in and can obtain instant anti-dandruff effect, and
Owing to different plant essential oil compositions are suitable for different scalp condition (oiliness, dryness and struvite), contribute to regulating oils and fats
Secretion, improves scalp microenvironment, maintenance scalp stratum corneum barrier.Therefore, after treatment cycle, disable two weeks, remain to keep strong
The scalp condition of health, it is to avoid dandruff occurs repeatedly.
Accompanying drawing explanation
Effective embodiment sample of Fig. 1 desquamation compositions and the comparison of 1% Zinc Pyrithione, 6 weeks anti-dandruff clinical trial assessments
Result
The non-limiting example of the composition of detergent of the present invention is presented herein below.Being only given to say of these embodiments
Bright purpose, can not be interpreted as limitation of the invention, because without departing from the spirit and scope of the present invention, and can
The present invention to be carried out many changes.In these embodiments, unless stated otherwise, all of concentration is all percentage by weight.
Detailed description of the invention
1. plant essential oil composition embodiment
2. table 1 plant essential oil composition embodiment component
2. desquamation compositions embodiment
Table 2 desquamation compositions embodiment component
The embodiment using plant essential oil composition A is respectively labeled as I-A-VII-A, the embodiment of plant essential oil composition B
It is labeled as I-B-VII-B, the like.
Desquamation compositions Detection of Stability
Desquamation compositions stability test condition is respectively as follows: heat-resistant stability 48 DEG C, 5 weeks；Cold-resistant experiment-18 DEG C, 24h,
Recover to room temperature to observe, totally 5 circulations.I-A-VII-A ... I-J-VII-J colloid is all stable without layering, without separating out.
2. the desquamation compositions I-VII application in shampoo
2.1 desquamation compositions I-VII application in shampoo: desquamation compositions embodiment I-VII is respectively according to 0.5% He
2.0% percentage by weight adds, and shampoo matrix components is identical, is made up of by weight percentage following components: lauryl alcohol polyoxy
Vinyl Ether ammonium sulfate-70,10%；Ammonium lauryl sulfate salt-70,5%；Cocoyl CAB-35,4%；Cocos nucifera oil acyl list
Ethanolamine, 1.5% cation guar gum, 0.4%, citric acid, 0.1%；Emulsified silicone oil 3.0%；Appropriate preservative and essence
And the water of surplus.
The effect detection of 2.2 desquamation compositions I-VII application in shampoo:
2.2.1 fungistatic effect detection: use and antibacterial around-France carry out fungistatic effect detection: bacterial strain uses therefor is Malassezia furfur
Reference culture (Malassezia furfur ATCC 44344)；Used medium is Leeming&Notman agar culture medium.
The biggest anti-dandruff antibacterial effect of bacteriostatic diameter may be the highest.
Table 3 shampoo composite fungistatic effect is evaluated
Note: VIII, adds the positive control of 1.0% Zinc Pyrithione
2.2.2 anti-dandruff effect sensory evaluation
Described sensory evaluation method is: by 40 embodiments with add the positive control (VIII) of 1.0% Zinc Pyrithione and do not have
There is the negative control VII and I, the IV of the conjunction interpolation of azoospermia line of oils adding anti-dandruff component, issue 120 testers' contrasts at random and make
With.Tester washes hair when using shampoo sample in the same manner, and every kind of shampoo uses 4 weeks.Anti-dandruff effect root
According to dandruff number and size come and tested personnel's sensory effects mark.Standards of grading use ten point system, and 1-2 is completely ineffective
Really, 3-4 divides DeGrain, 5-6 to divide effective, and 7-8 divides effect notable, and 9-10 divides effect highly significant.Various shampoo groups
Compound using effect evaluation result is listed in table 3.
The anti-dandruff effect sensory evaluation of table 4 shampoo composite
3. the desquamation compositions I-VII application in hair conditioner
The application in hair conditioner of 3.1 desquamation compositions I-VII: desquamation compositions embodiment I-VII respectively according to 0.2%,
1.0% percentage by weight adds, and hair conditioner matrix components is identical, and VIII is the positive control adding 1.0% Zinc Pyrithione, and VII is
Without adding the negative control of anti-dandruff active component.It is made up of by weight percentage following components: octadecyl trimethyl ammonium chloride
1.0%, C16/C18 mixed alcohol 2.0%, emulsified silicone oil 3.0%, glyceryl monostearate 0.3%.
3.2 desquamation compositions I-VII application sensory effects in hair conditioner is evaluated
Sensory evaluation method is commented with 2.2.1 dandruff control shampoo containing sense organ efficacy assessments, various hair conditioner composition using effects
Valency average results is listed in table 4.
The anti-dandruff effect sensory evaluation of table 5 hair conditioner composition
The most anti-dandruff eficac Clinical is assessed
By effective embodiment III-A ...-J and VI-A ... the sample of-J issues the age at random in 18-60 one full year of life, dandruff disease
Disease clinical assessment be moderate to the patient 30 of severe, with VIII 1% Zinc Pyrithione washing liquids as positive control, carry out half a head survey
Examination.After tester first washes hair 2 weeks with the common shampoo of same matrix, the every 1-2 of shampoo composite of the present invention on probation
It cleans scalp and hair according to using method of the present invention, and every kind of cleanout fluid uses 4 weeks, uses same matrix the most again
Common shampoo wash hair 2 weeks.Mark according to dandruff state (free, attachment), dandruff size (tiny, lamellar, big lamellar), head
The bits index such as quantity and scalp erythema is marked: 0 is divided into entirely without dandruff state, and 9 are divided into very serious dandruff state.Note
Record use the common shampoo of same matrix to wash hair 2 weeks after score and use 1 week, 2 weeks, 3 weeks, scoring after 4 weeks and disable 2
Mark after week, be plotted against time with average mark.Described anti-dandruff hair conditioner and dandruff control shampoo containing are with the use of better, after 2 weeks
Can obtain the fungistatic effect of highly significant, and there is no rebound phenomena with common shampoo after 2 weeks.
Anti-dandruff clinical assessment result (Fig. 1) shows, effective embodiment sample of desquamation compositions of the present invention and 1%
Close anti-dandruff effect is shown in Zinc Pyrithione comparison during use, and anti-dandruff lotion embodiment sample of the present invention
Obvious rebound phenomena is not had after disabling 2 weeks.
Claims (8)
1. a desquamation compositions, its feature at component and the content of compositions is: Zinc Pyrithione percentage by weight is 2.0-
20.0%；Plant essential oil composition percentage by weight is 5.0-15.0%；Suspension dispersive agent percentage by weight is 0.3-2.0%；
Water is or/and alcohol weight ratio 63.0-92.7%.
Wherein said plant essential oil composition is cupressus sempervirens quintessence oil, ginger essential oil, inner essential oil, Peppermint essential oil, cubeb litsen tree
Fruit oil, rosemary ethereal oil, Herba Lysimachiae foenum-graeci quintessence oil, cinnamon essential oil, Eucalyptus globulus Labill leaf quintessence oil, clove oil, Juniperus communis fruit oil alternate leaf white thousand
Layer quintessence oil, Herba Pogostemonis essential oil, medicine Herba Salviae Japonicae essential oil, Herba Origani Vulgaris quintessence oil, Radix Cymbopogonis Citrati quintessence oil, the specific combination of Radix Artemisia ordosicae quintessence oil.
Desquamation compositions the most according to claim 1, it is characterised in that described plant essential oil composition is cupressus sempervirens
Quintessence oil and the compositions of Herba Lysimachiae foenum-graeci quintessence oil volume ratio 1:100-5:1.
Desquamation compositions the most according to claim 1, it is characterised in that described plant essential oil composition be Eucalyptus globulus Labill leaf quintessence oil,
Melaleuca alternifolia quintessence oil and the compositions of Herba Lysimachiae foenum-graeci quintessence oil volume ratio 2:5:3-1:7:2.
Desquamation compositions the most according to claim 1, it is characterised in that described plants essential oil is rosemary ethereal oil, cubeb litsen tree
Fruit oil, Peppermint essential oil and the compositions of Juniperus communis fruit oil volume ratio 2:1:6:1-6:1:2:1.
Desquamation compositions the most according to claim 1, it is characterised in that described plants essential oil is thyme oil, Ceylon's meat
Osmanthus quintessence oil, ginger essential oil, the compositions of clove oil volume ratio 1:4:4:1-5:2:2:1.
Desquamation compositions the most according to claim 1, it is characterised in that described plants essential oil is Herba Pogostemonis essential oil, medicine rat-tail
Grass quintessence oil, Herba Origani Vulgaris quintessence oil, Radix Cymbopogonis Citrati quintessence oil, the compositions of Radix Artemisia ordosicae quintessence oil volume ratio 1:1:1:1:1-4:2:2:1:1.
7. desquamation compositions described in claim 1 is in the application preparing anti-dandruff type shampoo, hair conditioner is washed in hair products.
The most according to claim 7, desquamation compositions is in the application preparing anti-dandruff type shampoo, hair conditioner is washed in hair products,
It is characterized in that described desquamation compositions 0.5-2.0% by weight percentage in shampoo adds, at hair conditioner by weight hundred
Proportion by subtraction is that 0.2-1.0% adds.
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| CN114129464A (en) * | 2021-10-29 | 2022-03-04 | 广州凡岛网络科技有限公司 | Scalp anti-dandruff composition for barrier repair and application thereof |
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| CN107898666A (en) * | 2017-10-11 | 2018-04-13 | 拉芳家化股份有限公司 | A kind of restoring consciouness of high-content geraniol plants essential oil synergy, anticreep hair-care shampoo |
| CN109106635A (en) * | 2018-08-20 | 2019-01-01 | 广东爱车小屋实业发展股份有限公司 | Draft essence composition, shampoo and preparation method thereof |
| CN112315835A (en) * | 2020-11-26 | 2021-02-05 | 广州环亚化妆品科技有限公司 | Oil-control and anti-dandruff composition and application thereof |
| CN114129464A (en) * | 2021-10-29 | 2022-03-04 | 广州凡岛网络科技有限公司 | Scalp anti-dandruff composition for barrier repair and application thereof |
| CN115058162A (en) * | 2022-07-06 | 2022-09-16 | 广西维一涂料制造有限公司 | High-strength bright interior wall coating |
| CN115058162B (en) * | 2022-07-06 | 2024-03-26 | 广西维一涂料制造有限公司 | Mildew preventive containing ZPT |
| CN116196243A (en) * | 2023-01-17 | 2023-06-02 | 广州宝仪生物科技有限公司 | Vegetable oil-control and dandruff-removing composition and preparation method thereof |
| CN116196243B (en) * | 2023-01-17 | 2023-09-15 | 广州宝仪生物科技有限公司 | Preparation method of plant oil-control and anti-dandruff composition |
| CN115919696A (en) * | 2023-03-01 | 2023-04-07 | 广州丝芬化妆品有限公司 | Composition with effects of removing dandruff and relieving itching, preparation method and application |
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