CN110709059A - Dandruff-removing and itching-relieving shampoo composition containing multi-element zinc - Google Patents
Dandruff-removing and itching-relieving shampoo composition containing multi-element zinc Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/27—Zinc; Compounds thereof
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/604—Alkylpolyglycosides; Derivatives thereof, e.g. esters
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
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- A—HUMAN NECESSITIES
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/732—Starch; Amylose; Amylopectin; Derivatives thereof
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/006—Antidandruff preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/008—Preparations for oily hair
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/02—Preparations for cleaning the hair
Abstract
A dandruff-removing and itching-relieving shampoo composition containing multi-element zinc, which comprises the following components in addition to water: (A) anionic surfactant in 5.0-40 wt% of the composition; (B) 1.0% to 10.0% by weight of the composition of sodium cocoamphoacetate and an alkyl glucoside; (C) 0.1 to 30 percent of the weight of the composition of a scalp anti-dandruff and antipruritic compound active substance containing polybasic zinc, wherein the anti-dandruff and antipruritic compound active substance is composed of zinc oxide, zinc pyrrolidone carboxylate, zinc gluconate, zinc lactate, zinc glycyrrhetinate, walnut shell extract, modified starch, phenoxyethanol and water; (D) cationic polymer in an amount of 0.05% to 2.0% by weight of the composition.
Description
Technical Field
The invention belongs to the field of daily chemicals, and particularly relates to an anti-dandruff and itching-relieving shampoo composition containing multi-element zinc.
Background
Dandruff is medically known as pityriasis capitis, a skin disease caused by malassezia (one of the fungi). The proliferation of malassezia on the scalp causes the hyperproliferation of the stratum corneum of the scalp, thereby promoting the abnormal desquamation of stratum corneum cells in the form of white dandruff, namely dandruff.
The research results of Lafang and the scalp microecological research project group of the institute of microbiology of Chinese academy of sciences show that the healthy scalp ecological environment is kept balanced by pH value, grease, flora, metabolic balance and the like. When the secretion of oil and fat of scalp is unbalanced, the oil of scalp is greasy; when the scalp flora is unbalanced in environment and lipophilous bacteria are bred in large quantity, the phenomenon of itching can occur; the scalp stratum corneum is metabolized too fast, so that the fungus clusters form dandruff, the scalp is not only itching and even the white objects in blocks fall off, and in addition, the distribution of scalp microorganisms of people in different areas is not the same.
In daily life, people select anti-dandruff shampoo, which is a widely adopted method for solving the dandruff problem. Salicylic acid, Zinc Pyrithione (ZPT), ketorolac ethanolamine salt (OCT), climbazole and ketoconazole are main anti-dandruff agents in the market for anti-dandruff shampoos and other anti-dandruff products, and Zinc Pyrithione (ZPT) has been widely used as an anti-dandruff agent in various hair washing products.
Zinc pyrithione is an organic zinc salt, which is named: the zinc bis (N-pyridine-2-thiol oxide anion) or the zinc N-2-pyrithione salt is a complex formed by coordination of N-2-Pyrithione (PT) serving as a ligand and zinc ions. In the solution, the complex is easy to decompose to form ligand and zinc ions, the zinc ions can adsorb and destroy the functions of cell membranes and enter the cell membranes to enable certain cell components to escape, interfere the cell metabolic process or interfere the action of various enzymes, so that the cells lose the due biological functions, finally the cells die, and finally the sterilization effect is achieved, so that the zinc plays an important role.
Zinc also has the effect of inhibiting 5-a reductase, thereby reducing excessive sebum secretion, supplementing zinc element to skin, and helping to maintain normal metabolism of skin. The zinc complex and the zinc-containing compound comprise organic zinc salt and inorganic zinc salt. The zinc pyrithione as an organic zinc salt has good oil control and bacteriostasis effects, but has certain degreasing property, and the scalp and hair are dry after use. The organic zinc salt also comprises organic zinc such as zinc gluconate, zinc lactate, zinc pyrrolidone carboxylate and the like, has good solubility, and has the effects of synergistically moisturizing, controlling oil, inhibiting bacteria and synergistically removing dandruff; in addition, inorganic zinc salts include zinc oxide, zinc chloride, zinc sulfate, zinc carbonate, and the like,
zinc oxide is insoluble in water like zinc pyrithione. The application of common zinc oxide (such as pharmaceutical grade zinc oxide) is that the zinc oxide ointment sold in the market has certain functions of astringency, antibiosis and antiphlogosis. The research finds that the antibacterial effect of the zinc oxide depends on the specific surface area of the zinc oxide. The zinc oxide has rich raw material sources and low price, and simultaneously, the zinc is also a mineral element necessary for human bodies. Zinc oxide, especially with a large specific surface area, has been one of the hot spots in the research of inorganic antibacterial agents.
The zinc oxide or nano zinc oxide with small particle size generally has large specific surface area and surface effect, is easy to generate affinity with contacted microorganisms to have bactericidal capacity, the mechanism of the zinc oxide or nano zinc oxide is similar to that of zinc pyrithione, ZnO slowly releases zinc ions in an aqueous medium, the zinc ions are gradually released, and due to the redox property of the zinc ions, when the zinc ions are combined with bacterial cell membranes, the zinc ions react with organic matters in the zinc ions to destroy the structure of membrane proteins, so that the activity of the membrane proteins is lost, and the aim of sterilization is fulfilled. Meanwhile, holes on the surface of the nano zinc oxide can generate electrons to directly participate in the reaction, more holes can generate more electrons, and the sterilization capability of the nano zinc oxide is improved. According to the contact type sterilization mechanism, zinc ions directly contact with bacteria to kill the bacteria, and when the bacteria are killed, the zinc ions are dissociated from thalli and then contact with other bacteria to complete a new sterilization task, so that good sterilization activity is displayed.
The invention aims to provide a shampoo composition, which achieves good effects of nourishing, astringing, controlling oil, inhibiting bacteria and relieving itching of scalp by using multi-zinc (organic zinc salt and inorganic zinc salt) and active ingredients which have the functions of relieving scalp, sterilizing and diminishing inflammation and are derived from plants.
Disclosure of Invention
The invention aims to provide an anti-dandruff and anti-itching shampoo composition containing multi-element zinc.
The dandruff-removing and itching-relieving shampoo composition of the invention contains the following components except water:
(A) anionic surfactant in 5.0-40 wt% of the composition;
(B) 1.0% to 10.0% by weight of the composition of sodium cocoamphoacetate and an alkyl glucoside;
(C) the anti-dandruff and anti-itching composite active matter comprises 0.1-30% of the composition weight, and consists of the following components:
an organic zinc mixture accounting for 10-30% of the weight of the composite active matter, wherein the organic zinc mixture is prepared by mixing zinc gluconate, zinc lactate, zinc pyrrolidone carboxylate and zinc glycyrrhetinate in a weight ratio of 1: 0.2;
inorganic zinc accounting for 1-20% of the weight of the composite active matter, wherein the inorganic zinc is zinc oxide, the particle size of the zinc oxide is 0.01-100 mu m, and the specific surface area is 30-100m2/g；
Walnut shell extract accounting for 0.01-5% of the weight of the composite active matter;
the suspending agent accounts for 1-10% of the weight of the composite active matter, and is modified starch;
phenoxyethanol accounting for 0.5-1 percent of the weight of the composite active matter
And the balance water;
(D) cationic polymer in an amount of 0.05-2.0% by weight of the composition.
The shampoo composition of the invention, wherein the anti-dandruff and antipruritic composite active matter is a composition (3 Zn) consisting of inorganic zinc salt such as zinc oxide, organic zinc salt such as organic acid mixture containing zinc pyrrolidone carboxylate, zinc gluconate, zinc lactate and zinc glycyrrhetinate, walnut shell extract and modified starch2+ScalpV，5Zn2+ScalpV)。
Shampoo compositions of the invention wherein the anionic surfactant is selected from: alkyl sulfate, alkyl polyoxyethylene ether sulfate, fatty acid monoglyceride sulfate, alkyl sulfonate, coconut oil isethionate, sodium alpha-olefin sulfonate, N-acyl sarcosinate, N-acyl glutamate, and alkyl phosphate.
The shampoo composition of the invention, wherein the weight ratio of sodium cocoamphoacetate to alkyl glucoside is 1: 1.
Shampoo compositions of the invention wherein the cationic polymer is selected from the group consisting of: at least one of a cationic cellulose polymer, a cationic guar polymer.
The invention has the following advantages:
the shampoo composition adopts the multi-element zinc technology and active ingredients derived from plants, has the combined effects of nourishing the scalp, controlling oil and inhibiting bacteria, and can realize the effects of removing dandruff and relieving itching for a long time after being used.
Detailed Description
The selection and action of the components of the present invention will be described in detail below.
The shampoo composition contains 0.1 to 25 percent, preferably 5 to 20 percent of the dandruff-removing and itching-relieving compound active matter by weight of the composition, wherein the dandruff-removing and itching-relieving compound active matter is cream viscous liquid, the density of the dandruff-removing and itching-relieving compound active matter is 1.150 to 1.240 at the temperature of 20 ℃, and the pH value is 5.5 to 7.0. The anti-dandruff itching-relieving composite active matter comprises the following specific components and activities: zinc oxide is used as dandruff remover, and can inhibit proliferation of malassezia and regulate oil secretion of scalp, and the zinc oxide is large specific surface zinc oxide (specific surface area of 30-100 m)2/g, particle diameter of 0.01-20 μm) has effect in inhibiting Malassezia; zinc gluconate: zinc lactate: zinc pyrrolidone carboxylate: zinc glycyrrhetinate in the organic acid zinc mixture are mixed according to the weight ratio of 1:0.2 to regulate scalp microecology, and have synergistic effects of nourishing and moisturizing scalp and hair, astringing scalp, regulating scalp grease secretion, inhibiting bacteria, removing dandruff and relieving itching, wherein zinc pyrrolidone carboxylate (ZnPCA) is a metal amino acid compound designed by increasing the synergistic effect, reduces sebum secretion by inhibiting 5 alpha-reductase and plays a role in synergistic antibacterial action, and zinc glycyrrhetinate has the effects of resisting inflammation, bacteria and allergy; the walnut shell extract is an ethanol extract and has the functions of oxidation resistance and bacteriostasis; the modified starch has the functions of suspending and stabilizing the anti-dandruff itching relieving composite active matter and stabilizing the composition system, and is the Suocare HS modified corn starch in Shanghai atlantoal industry.
The shampoo composition contains a composition of coconut oil hydroxyethyl sodium sulfonate and lauryl alcohol polyoxyethylene ether sodium sulfate which account for 5.0-40% of the weight of the composition, the weight ratio of the coconut oil hydroxyethyl sodium sulfonate to the lauryl alcohol polyoxyethylene ether sodium sulfate is 1:2-2:1, the coconut oil hydroxyethyl sodium sulfonate is abbreviated as SCI, and the structural formula of the composition is as follows: RCOOCH2CH2S03Na, R ═ C12-C16 alkyl, 85% active content, white appearance, mildness and hard water resistance. The sodium laureth sulfate is called AES for short, and has a structural formula of RO (CH2CH2O) nSO3Na, wherein R is C12-C16 alkyl, n is 2-3, and preferably, the average ethoxylation degree is n is 3. The content of active substances of the commercial product of the sodium laureth sulfate is 70 percent, and the appearance of the commercial product is white or light yellow paste. The compounding of the sodium coco hydroxyethyl sulfonate and the sodium laureth sulfate can generate good synergistic effects, such as: has good washing ability, excellent mild performance, hard water resistance and the like.
The shampoo composition of the invention contains a composition of sodium cocoamphoacetate and alkyl glucoside, wherein the weight percentage of the composition is 1.0% to 10.0%, and the ratio of the sodium cocoamphoacetate to the alkyl glucoside is 1: 1. the coconut oil based amphoteric sodium acetate is colorless to yellowish transparent viscous liquid, the content of active substances of a commercial product is 30%, the viscosity of the product is 5000-10000 at 25 ℃, the content of sodium chloride is less than 9.0%, the pH value of a 1% aqueous solution is 6.0-8.0, the structural formula of the product is RN (CH2COONa)2, the irritation of the coconut oil based amphoteric sodium acetate is low, the coconut oil based amphoteric sodium acetate is particularly mild to skin and eyes, the irritation of the coconut oil based amphoteric sodium acetate can be obviously reduced by matching with an anionic surfactant, the coconut oil based amphoteric sodium acetate has good foaming power, the foam is rich and fine, the skin feel is good, and the foam state of a formula system can be obviously improved. The alkyl glucosides include lauryl glucoside, coco glucoside, decyl glucoside and octyl/decyl glucoside, preferably decyl glucoside, which are light yellow turbid viscous liquids with an active content of 51% to 55% in a commercial product having a 20% 15% isopropanol solution with a pH of 11.5 to 12.5 and a viscosity of 1000-6000 at 25 ℃. Decyl glucoside, which is naturally derived, has excellent mild cleansing power and can improve the foaming properties of shampoos, is preferred in the present invention. The amount of foam and the foam stability are improved. The combination of cocoampho sodium acetate and decyl glucoside provides good foam and skin compatibility, minimizes irritation and increases foaming speed.
The shampoo composition of the invention comprises 0.05% to 3.0% by weight of the composition of a cationic polymer selected from the group consisting of: at least one of a cationic cellulose polymer, a cationic guar polymer, preferably a cationic guar. The cationic guar gum is a product obtained by quaternizing guar gum, the main component of the cationic guar gum is guar gum propyl trimethyl ammonium chloride, a series of cationic guar gum products can be obtained according to different substitution degrees, the preferable substitution degree is 0.1-0.2, the nitrogen content is 1.3-1.7%, and the viscosity of 1% aqueous solution of the cationic guar gum used in the invention is 3500 mPa.s-4500 mPa.s at 25 ℃; the cationic cellulose polymer is a copolymer of hydroxyethyl cellulose and alkyl trimethyl ammonium chloride, and can be divided into the following components according to different cationic substitution degrees: high cationic degree of substitution JR, medium cationic degree of substitution LR and low cationic degree of substitution LK, preferably medium cationic degree of substitution of cationic cellulose.
The shampoo compositions of the present invention may also contain other optional ingredients including pearlizing agents, viscosity modifiers, chelating agents, pH modifiers, preservatives, coloring agents, fragrances and the like. From 0.05% to 3.0% by weight of the composition of a pearlescent agent, non-limiting examples of which are: ethylene glycol monostearate monoester and ethylene glycol distearate, propylene glycol monostearate and glyceryl palmitate, magnesium alkyl stearamide, finely divided zinc oxide and titanium dioxide, preferably ethylene glycol distearate. The viscosity modifier is 0.1% to 5.0% by weight of the composition, non-limiting examples of which are: sodium chloride, ammonium chloride, monoethanolamine chloride, sodium sulfate, ammonium phosphate, hydroxyethyl cellulose, hydroxypropyl cellulose, copolymers of acrylic acid and long-chain alkyl methacrylates, acrylate/stearyl ether-20/methacrylate copolymers, methyl glucoside polyoxyethylene ether (120) dioleate, and the like. The chelating agent is present in an amount of 0.01% to 0.30% by weight of the composition, non-limiting examples of which are: ethylenediaminetetraacetic acid, disodium ethylenediaminetetraacetate, trisodium ethylenediaminetetraacetate, tetrasodium ethylenediaminetetraacetate, etc., preferably disodium ethylenediaminetetraacetate; non-limiting examples of such pH adjusting agents are: citric acid, phosphoric acid, triethanolamine, sodium hydroxide, etc., adjusting the pH of the system to 5.0 to 8.0, preferably 6.5 to 7.5; the selection of the preservative, the essence and the pigment meets the regulation of the cosmetic hygiene standard, and safe raw materials are selected.
In the shampoo composition of the present invention, in addition to the above-mentioned components, a desired amount is made up with water.
Preparation method
(1) Preparing the walnut shell extract: drying walnut shells, grinding the walnut shells into 200 meshes by using a three-roller mill, extracting by using 95 ethanol as an extracting agent, wherein the material-liquid ratio is 1: 20, leaching at 45 ℃, adjusting the ultrasonic power to 250W, leaching for 2 hours, filtering and concentrating under reduced pressure to obtain an ethanol extract.
(2) Preparing the anti-dandruff itching-relieving composite active matter: dispersing modified starch in water, heating and stirring until dissolving, adding phenoxyethanol, organic acid zinc mixture (weight ratio 1:0.2), walnut shell extract and zinc oxide, and stirring well for use.
(3) Preparation of shampoo compositions of the invention:
shampoo compositions of the invention may be prepared by any known or otherwise effective technique suitable for providing shampoo compositions, including conventional formulation and mixing techniques, with the addition of the anti-dandruff antipruritic complex active at about 50 ℃ during the final cooling phase of the process.
Application method
The shampoo composition of the invention is used in a conventional manner for cleaning and conditioning hair, and mainly comprises the following steps:
(A) wetting the hair with water;
(B) applying to the hair an effective amount of the shampoo composition of any of the preceding claims, generally in the range of from 1 gram to 50 grams, preferably from 2 to 20 grams;
(C) rinsing the shampoo composition on the hair with water.
These steps can be repeated as many times as necessary to achieve the desired cleansing, moisturizing, conditioning, anti-dandruff, etc. benefits.
Examples
The following are non-limiting examples of shampoo compositions of the invention. These examples are given solely for the purpose of illustration and are not to be construed as limitations of the present invention, as many variations thereof are possible without departing from the spirit and scope of the invention. In the examples, all concentrations are in weight percent unless otherwise specified. The term "minor substances" is used to refer to optional substances such as preservatives, viscosity modifiers, pH modifiers, fragrances, colors, and the like, the selection of which minor substances will vary depending upon the physical and chemical characteristics of the particular ingredients selected to make the present invention.
Preparation examples I to X
A suitable method for preparing the shampoo compositions described in examples I-X is as follows: adding a proper amount of water into a reaction tank, adding guar gum for dispersing under slow stirring, heating to 60-80 ℃ under slow stirring, and adding a proper amount of citric acid for neutralization. Then adding sodium lauryl alcohol ether sulfate, sodium coconut hydroxyethyl sulfonate, sodium coconut oil amphoacetate, decyl glucoside, ethylene glycol stearic acid diester and ethylene diamine tetraacetic acid (if the substances are used), completely dispersing and dissolving the substances, keeping the temperature for 30 minutes, and starting to reduce the temperature. When the temperature is reduced to about 50 ℃, the anti-dandruff and anti-itching compound active substance, sodium chloride, citric acid, preservative, pigment, essence and the like are added and continuously stirred to ensure that a uniform mixture is obtained. After all the components are added, a viscosity modifier and a pH modifier may be added as needed to adjust the viscosity and pH of the product to 6.5 to 7.5. Optionally, a small amount of water may be added to make up.
Examples I to V (Table 1)
Examples VI to X (Table 2)
Best mode for carrying out the invention (Table 3)
The contents (weight ratio) of each component agent of the anti-dandruff and anti-itching compound active matter in the examples I to X are as follows: contains 20% of organic zinc mixture, wherein the organic zinc mixture is prepared from zinc gluconate, zinc lactate, zinc pyrrolidone carboxylate and zinc glycyrrhetinate in a weight ratio of 1: mixing at a ratio of 1: 0.2; contains 2% of walnut shell extract; contains 16.6% of zinc oxide with particle diameter of 0.05 μm and specific surface area of 80m2(ii)/g; contains 1% phenoxyethanol; contains 5% of modified starch and the balance of water.
Inventive blank control example (Table 4)
Physical and chemical indexes of sense
5.3.4 detection Standard
The detection standard of the shampoo composition meets the national standard GB/T29679 shampoo, and the detail is shown in Table 5.
TABLE 5 sensory, physicochemical, hygienic indicators
Zinc oxide bacteriostasis experiment
Bacteriostatic test and experimental method
The method is a universal method for testing the potency of antibiotics at home and abroad, and is also a method specified by pharmacopoeias of various countries. And placing the oxford cup containing quantitative bacteriostatic drugs on an agar plate inoculated with the bacteria to be detected, wherein the drugs contained in the oxford cup continuously diffuse around the oxford cup to form a decreasing gradient concentration. The growth of the bacteria to be detected is inhibited within the bacteriostatic concentration range around the oxford cup, and a transparent zone (i.e. bacteriostatic zone) with sterile growth is formed. The size of the inhibition zone reflects the sensitivity of the bacteria to be detected to the determination drug, and is in a negative correlation with the minimum (or Minimum) Inhibitory Concentration (MIC) of the drug to the bacteria to be detected, i.e., the larger the inhibition zone is, the smaller the MIC is, and the stronger the inhibitory effect is.
The strain is as follows: malassezia furfur ATCC 44344. The strains are purchased from Guangdong culture Collection of microorganisms.
Preparing a culture medium: the culture medium is weighed according to the formula and then dissolved in a proper amount of deionized water, the mixture is shaken up, and water is added to the required volume.
Determination of bacteriostatic efficacy: the medium was shaken well and poured into plates, and the plates were cooled to solidify, about 15mL each. The bacterial suspension with a certain proportion is dripped on a flat plate, and a coating rod is used for uniformly coating the surface of the flat plate for 3 times. The plate was covered and dried at room temperature for 5 min. An Oxford cup having an inner diameter of 6mm was gently placed on the solidified medium with tweezers. Samples were aspirated with a 1mL disposable syringe needle and added to the Oxford cups, approximately 250. mu.L of sample per cup. After culturing for a certain time at a proper temperature, observing the size of the inhibition zone or measuring the diameter of the inhibition zone by using a vernier caliper. When the inhibition zone is measured, the inhibition zone which is uniform and completely aseptically grows is selected for measurement. The diameter of the catheter is measured by taking the outer edge of the bacteriostatic ring as a boundary.
Parameters of the zinc oxide sample with large specific surface area: specific surface area of 80m or more2(g) a particle diameter of 0.05 μm or more.
Experimental methods
(1) Samples of zinc oxide (large specific surface area) were dispersed in acetone (ZnO 25% content) and then diluted to 0.16-2.5% concentration zinc oxide dispersion solutions for use, with blank (no ZnO) samples being water and acetone, respectively.
(2) The culture medium is prepared (see table 6), the spore-forming bacteria are placed in the culture medium, water, acetone dispersion solutions with the content of less than 0.16%, 0.16%, 0.3%, 0.6%, 1.25%, 2.5% and acetone dispersion solution containing 1.5% ZPT and the like are respectively placed in the culture medium containing the rhodochrous furfuryl (spore-forming bacteria), and then the mixture is cultured for 3 days at 37 ℃ under aerobic condition, and the growth condition of the spore-forming bacteria is observed (see table 7).
Medium Table 6
Table 6, the medium was weighed according to the recipe and dissolved in a suitable amount of deionized water, shaken up and added with water to the desired volume. Placing the conical flask on an electromagnetic oven, heating and stirring until the culture medium solution boils slightly, and keeping the state for 5-10 min. Sterilizing at 121 deg.C for 20 min, cooling to 60 deg.C, and taking out if there is no contamination.
Bacteriostatic experiments-Table 7
The results in table 7 show that no formation of inhibition zones was observed for both the blank control sample (containing no zinc oxide) and the sample with a large specific surface area zinc oxide content of < 0.16%, indicating that the three samples did not have the effect of inhibiting the growth of malassezia furfur (spore dander bacteria); the zinc oxide with large specific surface area contains 0.16 percent, 0.3 percent, 0.6 percent, 1.25 percent and 2.5 percent of zinc oxide, the growth of the bacteria to be detected is inhibited within the range of the bacteriostatic concentration around the oxford cup, a transparent zone (i.e. bacteriostatic zone) with aseptic growth is formed, and the bacteriostatic zone shows a trend from small to large; the formation of an obvious inhibition zone can be observed by 1.5 percent ZPT, and the size of the inhibition zone is similar to that of the inhibition zone formed by zinc oxide with the content of 2.5 percent and large specific surface area.
Minimum Inhibitory Concentration (MIC) of zinc oxide
The medical grade zinc oxide and the zinc oxide with large specific surface area are respectively suspended in acetone to respectively prepare suspensions with the concentration from the lowest concentration of 90PPM to 6000PPM, the suspensions are divided into equal parts and put into a culture medium for culture, and finally the lowest concentration MIC of inhibited malassezia is observed, which is shown in Table 8.
Table 8.
Table 8 above can derive: the zinc oxide with large specific surface area has lower bacteriostatic (dandruff spore bacteria) concentration than the medical grade zinc oxide, which shows that the bacteriostatic effect of the zinc oxide with large specific surface area is stronger.
Clinical experiment on dandruff removal and itching relieving of shampoo composition
The test method comprises the following steps: 60 volunteers with moderate dandruff and itching were selected, healthy scalp patients without seborrheic dermatitis, allergy and wound were asked, before trial, sensory and hair image evaluations were performed on the patients, and the patients were allowed to use the shampoo of the preferred embodiment of the present invention and the shampoo of the blank embodiment of the present invention, continuously (samples were used according to daily use frequency), after 14 days (two weeks), the patients were stopped, and after 12 hours, 24 hours and 48 hours of stopping, the dandruff and itching status were observed, respectively, and scored, and the comprehensive evaluations are shown in table 9.
The score before and after the use of the volunteer skin was 1, 2, 3, 4, 5, the higher the score the better the effect: 1-2: invalid; 2-3: medium; 3-4: good; 4-5: very good.
Sensory evaluation of the hair of the volunteers before and after the use of the product. TABLE 9
In Table 9, the percentage of inefficiency in the preferred embodiment of the invention is significantly lower than in the blank embodiment of the invention, as seen by the statistics of reduced dandruff and reduced head itch.
Claims (5)
1. A dandruff-removing and itching-relieving shampoo composition containing multi-element zinc comprises the following components in addition to water:
(A) anionic surfactant in 5.0-40 wt% of the composition;
(B) 1.0% to 10.0% by weight of the composition of sodium cocoamphoacetate and an alkyl glucoside;
(C) the anti-dandruff and anti-itching composite active matter comprises 0.1-30% of the composition weight, and consists of the following components:
organic zinc mixture accounting for 10-30% of the weight of the composite active matter, wherein the organic zinc mixture is zinc gluconate, zinc lactate and zinc pyrrolidone carboxylate: zinc glycyrrhetinate, and the weight ratio of zinc glycyrrhetinate to zinc glycyrrhetinate is 1: 1: mixing at a ratio of 0.2;
inorganic zinc accounting for 1-20% of the weight of the composite active matter, wherein the inorganic zinc is zinc oxide, and the particle size of the zinc oxide is 0.01-100 mu m; the specific surface area is 30-100m2/g；
Walnut shell extract accounting for 0.01-5% of the weight of the composite active matter;
the suspending agent accounts for 1-10% of the weight of the composite active matter, and is modified starch;
phenoxyethanol accounting for 0.5-1% of the weight of the composite active matter;
and the balance water;
(D) cationic polymer in an amount of 0.05-2.0% by weight of the composition.
2. A shampoo composition according to claim 1, wherein the zinc oxide has a particle size of from 0.1 μm to 30 μm; the specific surface area is 50-90m2/g。
3. The shampoo composition of claim 1, wherein the anionic surfactant is selected from the group consisting of: alkyl sulfate, alkyl polyoxyethylene ether sulfate, fatty acid monoglyceride sulfate, alkyl sulfonate, coconut oil isethionate, sodium alpha-olefin sulfonate, N-acyl sarcosinate, N-acyl glutamate, and alkyl phosphate.
4. The shampoo composition of claim 1, wherein the ratio of sodium cocoamphoacetate to alkyl glucoside is 1: 1.
5. The shampoo composition of claim 1, wherein the cationic polymer is selected from the group consisting of: a cationic cellulose polymer or a cationic guar polymer.
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| Application Number | Priority Date | Filing Date | Title |
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| PCT/CN2018/123837 WO2020132930A1 (en) | 2018-12-26 | 2018-12-26 | Anti-dandruff anti-itch shampoo composition containing multiple-component zinc |
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| CN115337212A (en) * | 2021-10-29 | 2022-11-15 | 博汇美萃生物工程技术(广东)有限公司 | Composition for relieving itching, removing dandruff and controlling oil and application thereof |
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