CN102716045B - Shampoo composition containing double anti-dandruff agents - Google Patents
Shampoo composition containing double anti-dandruff agents Download PDFInfo
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Abstract
The invention relates to a shampoo composition containing double anti-dandruff agents. The shampoo comprises (A) anionic surfactants accounting for 5.0 percent to 30 percent of the weight of the composition, amphoteric surfactants accounting for 1.5 percent to 8.0 percent of the weight of the composition, thickening agents accounting for 0.5 percent to 5.0 percent of the weight of the composition and regulating agents accounting for 2.0 percent to 10 percent of the weight of the composition; (B) anti-dandruff sterilization agents accounting for 0.01 percent to 3.0 percent of the weight of the composition, wherein the anti-dandruff sterilization agents are compositions of PTO (piroctone olamine) and ZPT (zinc pyrithione) at a proportion being 1:100-2:3; (C) additives with anti-dandruff and synergistic effects accounting for 0.01 percent to 1.0 percent of the weight of the composition, and at least one kind of materials selected from vitamin E, provitamin B5 and vitamin B12; (D) cationic protein hydrolysate accounting for 0.05 percent to 1 percent of the weight of the composition; and (E) the balance water.
Description
Technical field
The invention belongs to household chemicals field, be specifically related to a kind of nourishing anti-dandruff shampoo composition that contains two anti-dandruff compositions.
Background technology
Dandruff is the metabolic product of human body head epidermis cell, and to be epidermis cell breed ripe outwards layer from basal layer to the normal metabolic processes of hair gradually passes, and forms horny layer and comes off.Modern because pressure is excessive, psychentonia, fatigue, shampoo inferior, the use of medicine, air-polluting increase the weight of and the effect of microorganism, antibacterial makes scalp cells Developmental and Metabolic Disorder, cell becomes greatly, thickens, comes off into the dandruff, brings great inconvenience to people's life.It has been generally acknowledged that the incomplete keratinization of scalp cells of superficial layer and the parasitism of pityrosporum ovale are the main causes that dandruff increases, the generation of dandruff is again for advantage has been created in microbial growth and breeding, and then cause scalp irritation, cause pruritus, the abnormal breeding of accelerometer chrotoplast.Therefore suppressing cellular keratinization speed, is the main path of control dandruff thereby reduce the metabolic speed of epidermis and sterilize.
Current anti-dandruff shampoo is mainly to adopt single anti-dandruff antibacterial to form as the formula that Zinc Pyrithione (ZPT) adds surfactant.The anti-dandruff product that the Zinc Pyrithione (ZPT) of take is main active, its action principle is that (1) is by passing through effectively to remove the too much sebum of scalp to the killing action of pityrosporum ovale (2).Zinc Pyrithione (ZPT) has certain anti-dandruff effect, is anti-dandruff dose of current main flow.But the hair washing product of ZPT matching surface activating agent technology and application in the middle of remain many deficiencies as, wash rear scalp and hair dry, there is the shortcoming that hair and scalp defat are strong and flushing conditioning property is poor, simultaneously, because defat is strong, zest and the metabolic speed of hair epidermis of scalp have been increased, and then the quickening (having increased the amount of the horn cell of scalp surface peeling) of the speed of initiation scalp epithelial cell generation keratinization, thereby make the anti-dandruff effect can not be lasting, not pregnancy ceased repiece scurf.This is to adopt at present single anti-dandruff product can not meet the main cause of consumer demand.
Summary of the invention
The object of this invention is to provide a kind of shampoo composite, said composition has the anti-dandruff effective feature of growing with the removing scurf and relieving itching persistent period.
The present composition comprises: be characterised in that and comprise:
(A) be applicable to the anion surfactant that accounts for composition weight 5.0% to 30% in shampoo composite, account for composition weight 1.5% to 8.0% amphoteric surfactant, account for the thickening agent of composition weight 0.5% to 5.0% and account for the conditioner of composition weight 2.0% to 10%;
(B) account for anti-dandruff dose of composition weight 0.01 to 3%; Wherein said anti-dandruff dose is the compositions of octopirox and pyrithione, and both part by weight are 1:100 to 2:3;
(C) account for the anti-dandruff Synergistic additives of composition weight 0.01% to 1.0%, described anti-dandruff Synergistic additives is selected from vitamin E, provitamin B
5,, vitamin B
12in at least one;
(D) account for 12～octadecyl dimethyl hydroxypropyl hydrolytic collagen ammonium chloride of composition weight 0.05% to 1.0%;
(E) surplus is water.
Shampoo composite of the present invention, wherein anion surfactant is selected from Laurel alkyl ammonium sulfate or polyoxyethylene lauryl ether ammonium sulfate, and described amphoteric surfactant is cocamido propyl betaine; Described thickening agent is phthalic acid amide; Conditioner is selected from, at least one in cationic cellulose polymer, cation melon glue, emulsified silicone oil;
Shampoo composite of the present invention, wherein said anti-dandruff dose is the compositions of pyridone ethanolamine and pyrithione zinc, and both part by weight are 1:10 to 1:1.5;
Shampoo composite of the present invention, wherein said pyridone ethanolamine is 1-hydroxy-4-methyl-6-(2,4, the compound of 4-tri-methyl-amyl)-2 (1H)-pyridone and monoethanolamine, as structure formula I, the mol ratio of wherein said 1-hydroxy-4-methyl-6-(2,4,4-tri-methyl-amyl)-2 (1H)-pyridones and monoethanolamine is 1:1:
Shampoo composite of the present invention, the mean diameter of Zinc Pyrithione granule is at most 5 μ m.
Shampoo composite of the present invention, wherein cation hydrolysis protein content accounts for 0.2% to 0.5% of composition weight
Its preferred component of shampoo composite of the present invention and content are:
(A) be applicable to the Laurel alkyl ammonium sulfate that accounts for composition weight 10% to 25% and polyoxyethylene lauryl ether ammonium sulfate in shampoo composite, account for composition weight 2.0% to 6.0% cocamido propyl betaine, account for the phthalic acid amide of composition weight 1.0% to 4.0% and account for the emulsified silicone oil of composition weight 3.0% to 8.0%;
(B) account for the anti-dandruff antibacterial of composition weight 0.05% to 2.0%, wherein said anti-dandruff antibacterial is the compositions of pyridone ethanolamine and Zinc Pyrithione, and both part by weight are 1:10 to 1:1.5;
(C) account for the anti-dandruff Synergistic additives of composition weight 0.05% to 0.5%, described anti-dandruff Synergistic additives is selected from vitamin B12;
(D) account for 12～octadecyl dimethyl hydroxypropyl hydrolytic collagen ammonium chloride of composition weight 0.1% to 0.5%;
And (E) surplus is water.
To be elaborated to compositional selecting of the present invention and effect below.
A. solvent
Nourishing anti-dandruff shampoo composition solvent of the present invention comprises anion surfactant, amphoteric surfactant, thickening agent and conditioner, and each in these components all have been described in detail hereinafter.
Surfactant in shampoo utilizes its infiltration, emulsifying and peptizaiton, and dirt is gone out from hair, scalp, plays clean effect.Nourishing anti-dandruff shampoo composition of the present invention comprises and accounts for composition weight 5.0% to 30%, preferred 10% to 25% the suitable anion surfactant being used on hair or skin, the compositions of preferred Laurel alkyl ammonium sulfate, polyoxyethylene lauryl ether ammonium sulfate, oxirane in the compositions of described polyoxyethylene lauryl ether ammonium sulfate (EO) adduct number is 2 to 4, and optimization ethylene oxide adduct number is 3.Other non-limiting example that is applicable to anion surfactant of the present invention also has: sodium laurylsulfate, lauryl alcohol potassium sulfate, polyoxyethylene lauryl ether sodium sulfate, polyoxyethylene lauryl ether potassium sulfate, glycerine monofatty ester sulfate, fatty alcohol sodium isethionate, N-lauroyl musculamine acid sodium, lauroyl Herba bromi japonici amino acid sodium, 1-isobutyl-3,5-dimethylhexylphosphoric acid potassium salt etc.Nourishing anti-dandruff shampoo composition of the present invention also comprises and accounts for composition weight 1.5% to 8.0%, preferably 2.0% to 6.0% the suitable amphoteric surfactant being used on hair or skin, preferably cocamido propyl betaine.Other non-limiting example that is applicable to amphoteric surfactant of the present invention also has dodecyldimethylammonium hydroxide inner salt, disodium alkyl polyoxyethylene sulfosuccinate, imidazoline type betanin, cocos nucifera oil both sexes sodium acetate, cocamidopropyl propyl amide hydroxyl sulphonic acid betaine etc.
Nourishing anti-dandruff shampoo composition of the present invention comprises and accounts for composition weight 0.5% to 5.0%, preferred 1.0% to 4.0% the thickening agent for suspend granular anti-dandruff dose and thickener composition, improve the stability of shampoo composite, the preferred phthalic acid amide of wherein said thickening agent, described phthalic acid amide trade name is TAB-2, by two hydrogenated-tallow group secondary amine and phthalic anhydride, made, it is a kind of multifunctional suspending stabilizing agent, can be used as emulsifying agent, suspending agent, can effectively stablize the shampoo composite that contains silicone oil and anti-dandruff dose, can with the present composition in all components compatibility, there is good salt tolerance, within the scope of wider pH, there is constant thickening effect, can make compositions viscosity is at room temperature 6000mPa.s to 12000mPa.s, preferred 8000mPa.s to 10000mPa.s.Other non-limiting example that is applicable to thickening agent of the present invention also has: sodium chloride, ammonium chloride, ETHANOLAMINE HYDROCHLORIDE, diethanolamine chloride, sodium sulfate, ammonium sulfate, disodium hydrogen phosphate, electrolyte and the polyglycol distearates such as phosphoric acid five sodium, polyethylene glycol mono stearate, polyethylene glycol dilaurate, Carboxymethyl cellulose sodium, hydroxyethyl-cellulose, hydroxypropyl emthylcellulose, trade name is acrylic acid/polyoxyethylene (20) octadecanol ether methyl acid copolymer of Acul yn22, trade name is the anionic thickeners such as acrylic copolymer of Aculyn33, trade name is the non-ionic thickening agent C of Aculyn44
10poly-carbamyl macrogol ester, Polyethylene Glycol, polyvinylpyrrolidone etc.
Nourishing anti-dandruff shampoo composition of the present invention comprises and accounts for composition weight 2.0% to 10.0%, preferably 3.0% to 8.0% be applicable to the conditioner on hair and skin, adding of conditioner is mainly the feel of washing rear hair in order to improve, make hair smooth, soft, be easy to combing.Wherein said conditioner is selected from, one or more compositionss in cationic cellulose polymer, cation melon glue, emulsified silicone oil.Described cationic cellulose polymer, have another name called poly-cellulose ether quaternary ammonium salt, to carry out by cellulose or derivatives thereof the product obtaining after quaternized, mainly contain polyquaternary ammonium salt-4, polyquaternary ammonium salt-6, polyquaternary ammonium salt-7, Polyquaternium-10, polyquaternary ammonium salt-17, polyquaternary ammonium salt-18 etc., preferably Polyquaternium-10.Described cation melon glue is the product obtaining after melon glue is quaternized, its key component is melon glue oxypropyl trimethyl ammonium chloride, according to the difference of substitution value, can obtain a series of cation melon glue product, preferably substitution value is 0.1 to 0.2, be used for cation melon glue of the present invention under 25 ℃ of conditions, the viscosity of its 1% aqueous solution is 2000mPa.s to 4000mPa.s, and its consumption is 0.02% to 3.0%, more preferably 0.05% to 1.0%; Described emulsified silicone oil is non-volatile polydimethylsiloxane, its consumption is 0.5% to 10%, preferably 1.0% to 8.0%, the viscosity recording at 25 ℃ for emulsified silicone oil of the present invention is preferably 100mPa.s to 2500000mPa.s, more preferred 500mPa.s to 1500000mPa.s.Select large particle diameter emulsified silicone oil and small particle diameter emulsified silicone oil to be used in conjunction with, improve dry cardability and the wet cardability of shampoo, the equal particle diameter of described large particle diameter emulsified silicone oil number is at 10 μ m to 30 μ m, preferably 15 μ m to 25 μ m; The equal particle diameter of described small particle diameter emulsified silicone oil number is at 0.01 μ m to 5 μ m, preferably 0.01 μ m to 2 μ m.Other is applicable to conditioner of the present invention and obtains non-limiting example in addition: Pfansteihl sodium, Oleum Ricini maleic acid glyceride, quaternary ammonium salt-82, different hard ester group ethyl imidazol(e) ethoxy sulfate, Fructus Hordei Germinatus amido propyl ammonio methacrylate etc.
B. anti-dandruff antibacterial
Nourishing anti-dandruff shampoo composition of the present invention comprises and accounts for composition weight 0.01% to 3.0%, preferred 0.05% to 2.0% suitable anti-dandruff dose of being used on hair or skin, anti-dandruff dose add the antimicrobial acivity that has improved shampoo composite.Wherein said anti-dandruff dose is the compositions of pyrithione and octopirox.Described octopirox trade name is the two friendly daily use chemicals in SY-OCT(Kunshan), its structural formula is (I), its chemistry is by name: 1-hydroxy-4-methyl-6-(2,4,4-tri-methyl-amyl)-2 (1H)-pyridone ethanolamine, for 1-hydroxy-4-methyl-6-(2,4, the compound of 4-tri-methyl-amyl)-2 (1H)-pyridone and monoethanolamine, wherein said 1-hydroxy-4-methyl-6-(2, the mol ratio of 4,4-tri-methyl-amyl)-2 (1H)-pyridone and monoethanolamine is 1:1:
Pyridone ethanolamine as one of anti-dandruff and itching-relieving agent in the present invention, safety, nontoxic, non-stimulated, use amount low (being generally 0.1-0.75%) in anti-dandruff product, it is by methods such as sterilization, antibacterial, antioxidation and decomposition oxides, fundamentally blocks the external factor that dandruff produces, can not only effectively kill the yeast that produces dandruff, can also effectively suppress the Ge Shi positive, feminine gender and various fungus and mycete simultaneously.Compare with conventional anti-dandruff dose of Zinc Pyrithione (ZPT), its solubility property and compound property are good, gentle non-stimulated, mix precipitation or lamination can not occur with cosmetic material.
Pyrithione structural formula of the present invention is (II), and in formula, M is the metal ions such as Cu, Zn, Na, and preferably M is Zn, i.e. Zinc Pyrithione; Described Zinc Pyrithione is itch agent and high-effective broad-spectrum fungicide of the anti-dandruff system that is acknowledged as highly effective and safe, still, compares with octopirox (PTO), and the zest of this compound is strong, large to the zest of eyes.In addition, its utmost point is insoluble in organic solvent and water, therefore should not prepare transparent shampoo.It and EDTA are incompatible, and meet non-ionic surface active agent and can make its active decline, therefore, when formulated product, can not contact with EDTA, non-ionic surface active agent separately.Its existence meeting simultaneously produces scattering to light, with the shampoo of its preparation, has certain photoextinction, and product pearl effect can be affected.And be applied to often there will be in shampoo formula sedimentation, and meet the easy variable color of iron ion, need add suspending agent and stabilizing agent.In the present invention, preferably the mean diameter of Zinc Pyrithione granule is at most 10 μ m, is most preferably at most 5 μ m.
The preferred 1:10 to 1:1.5 of the ratio of pyridone ethanolamine and Zinc Pyrithione in the present invention, can obtain good anti-dandruff effect.Other non-limiting example that is applicable to anti-dandruff dose of the present invention also has: endecatylene acid derivative, 1-(4-chlorophenoxy)-1-(1H-imidazole radicals)-3,3-dimethyl-2-butanone etc.
C. anti-dandruff Synergistic additives
Suppressing cellular keratinization speed (reducing the metabolic speed of epidermis) and sterilization is the main path of control dandruff.In the present invention, the Main Function principle of pyrithione and octopirox compositions is by its bactericidal action, to suppress the generation of pityrosporum ovale, thereby plays anti-dandruff effect.Yet in actual life, due to environmental pollution, the existence of the factor such as endocrine and chemical stimulation, tend to cause " ecological environment " of scalp to worsen, the patent of being quoted from as US Patent No. 5053222 is pointed out, contains Zinc Pyrithione (ZPT) anti-dandruff shampoo and there is certain effect to removing the dandruff, but " ecological disorderly " that also may cause scalp simultaneously causes too much coming off or excessive keratinization phenomenon of scalp---one of another one factor that the dandruff generates.Therefore, thus another object of the present invention is to solve scalp extremely to come off and reduce the generation of the dandruff.US Patent No. 6110472 discloses a kind of shampoo that contains Vitamin B12, the processing extremely coming off for scalp.The present invention also draws by lot of experiments, and other vitamin is as vitamin E, and dexpanthenol can nourish scalp and send out a tip, plays the effect that prevents that scalp from coming off extremely, thereby contributes to the realization of anti-dandruff function.
Therefore, in the present invention, except anti-dandruff antibacterial, also contain and account for composition weight 0.01% to 1.0%, be preferably 0.05% to 0.5% anti-dandruff Synergistic additives, described anti-dandruff Synergistic additives is selected from vitamin substances as vitamin E, provitamin B
5and vitamin B
12in at least one.
Vitamin comprises a series of different organo-functional groups as alcohol, acid, sterin, quinone.Can be classified into fat dissolubility vitamin and water-soluble vitamin.The fat dissolubility vitamin using in daily chemical products compositions comprises: vitamin A, vitamin D
2, vitamin D
3, vitamin K
1and vitamin E; Water-soluble vitamin comprises: vitamin C, vitamin B
1, vitamin B
2, vitamin B
3, provitamin B
5, vitamin B
6, vitamin B
12deng.
The vitamin E using in the present invention is selected from Vitamin E acetate, linoleic acid ester of vitamin e and vitamin e succinate, and preferred vitamin e acetate (BASF AG's production), the vitamin e acetate using in the present invention is fat dissolubility vitamin, there is good antioxygenic property, hair growth promoting, hair care are had to clinical effect, contribute to prevent the generation of scalp lipid peroxidation, to anti-antidandruff, produce helpful; Described provitamin B
5having another name called pantothenylol, is water-soluble vitamin, is vitamin B
5hydrogenation products, provitamin B in skin and hair
5can change vitamin B into, be deep into root of hair, control moisture in hair, prevent trichoxerosis, come off, bifurcated, be entangled with, give hair luster, accelerate hair growth, in addition, provitamin B
5there is good infiltration and moisture-keeping functions, the balance that contributes to the maintaining head severe edema due to hypofunction of the spleen to divide, thus prevent the generation of the abnormal obscission of scalp.Provitamin B
5for Roche Holding Ag produces, preferably the specific rotatory power of pantothenylol is+29.0 °～+ 31.5 °, and index of refraction is 1.495～1.502.
Vitamin B in the present invention
12for water-soluble vitamin ，Wei Roche Holding Ag produces, it act as and prevents extremely coming off of scalp.
D. cation is hydrolyzed albumen
The present composition also comprises and accounts for composition weight 0.05% to 1%, preferably 0.1% to 0.5% cation hydrolysis albumen, preferably 12～octadecyl dimethyl hydroxypropyl hydrolytic collagen ammonium chloride.
The invention uses cationic protein hydrolyzate quaternized hydrolyzed collagen, through a long chain quaternary ammonium salt and butter-based hydroxypropyl hydrolyzed collagen synthesized by the reaction of the twelve-octadecyldimethyl hydroxypropyl hydrolyzed collagen chlorine ammonium molecule (referred quaternary ammonium hydrolyzed collagen concentrate conditioner), and concentrated using membrane separation technology, quaternary ammonium and hydrolysis to remove free collagen, high quality quaternary ammonium hydrolyzed collagen protein conditioner concentrate.Cation hydrolysis albumen of the present invention is 28%～32% containing quaternized activity concentration, quaternized active matter molecule is amphipathic cationic compound, hydrophilic segment is hydrolytic collagen, lipophilic portion is 12～octadecyl dimethyl hydroxypropyl quaternary ammonium salt, the etherate that the oligopeptide that active system is comprised of 10～20 aminoacid is combined with 12～octadecyl dimethyl hydroxypropyl quaternary ammonium salt, molecular weight distribution is in 1700Da～3600Da, molecular weight is moderate, permeability is stronger, both can realize nourishing at the surperficial damaged part of hair and repair; Also can partly be deep into the larger impaired hole of hair inside, directly supplement the basic structural unit-aminoacid of alpha-Keratin.Therefore, the cation hydrolysis albumen that the present invention uses is the polyfunctional surfactant that the clean ability of a class is strong, have maintenance hair quality and bactericidal action concurrently, play in the present invention and coordinate and neutralize the effect that other surfactant stimulates, thereby contribute to the effect of the moderately removing dandruff of system.Cations present invention hydrolyzed protein (collagen hydrolyzate quaternized) as a pale yellow transparent liquid, pH4 ~ 6, the total nitrogen content of 4.0 to 5.5, the active substance content 30 ± 2, for the day of Huzhou Star Ltd .
The present composition also comprises and accounts for composition weight 0.01% to 3.0%, preferably 0.05% to 1.0% cationic surfactant, preferably INCROQUAT TMC-80 ECONOL TM22.
Nourishing anti-dandruff shampoo composition of the present invention also comprises and accounts for composition weight 0.2% to 5.0%, preferred 0.5% to 2.5% foam stabilizer, described foam stabilizer refers to the surfactant with prolongation and stable foam, is mainly selected from alkylolamides, preferred fatty acid single ethanol amide.
Nourishing anti-dandruff shampoo composition of the present invention can also comprise other optional components, comprises chelating agen, pearling agent, pH adjusting agent, antiseptic, pigment and spice etc.The non-limiting example of described chelating agen has: ethylenediaminetetraacetic acid, disodiumedetate, tetrasodium ethylenediamine tetraacetate, citric acid, phosphoric acid, ascorbic acid etc., preferably disodiumedetate; The non-limiting example of described pearling agent has: ethylene glycol stearate, polyglycol distearate, preferably ethylene glycol bisthioglycolate sodium stearate; The non-limiting example of described pH adjusting agent has: citric acid, phosphoric acid etc., and optimization citric acid, the pH of regulation system is 5.0 to 8.0, and preferably 5.5 to 6.6; Choosing of described antiseptic, essence, pigment, meets the regulation of hygienic standards for cosmetics, selects safe raw material.
In nourishing anti-dandruff shampoo composition of the present invention, except the above component, water is mended to aequum.
Compared with prior art, the present invention has the following advantages:
The surfactant that shampoo composite of the present invention comprises in containing conventional shampoo, thickening agent, conditioner, also contain two anti-dandruff compositions and anti-dandruff Synergistic additives.Two anti-dandruff dose of compositions are comprised of the composite use of octopirox (PTO) and Zinc Pyrithione (ZPT), and its scientific matching is used, and has brought potentiation and more lasting anti-dandruff effect.(the anti-dandruff science and technology of PTO+ZPT=BPT).
Preparation method
Shampoo composite of the present invention can by any known or other be effectively applicable to provide the technology of shampoo composite to prepare, the method for preparing nourishing anti-dandruff shampoo composition of the present invention comprises conventional preparation and hybrid technology.
Using method
Nourishing anti-dandruff shampoo composition of the present invention is used in the mode clean and conditioning hair of routine, mainly comprises following step:
(A) water is by hair moistening;
(B) on described hair, use the shampoo composite of the aforementioned any one claim of effective dose, the scope of described effective dose is generally 1 gram to 50 grams, preferably 2 to 20 grams;
(C) with the shampoo composite on hair described in water rinse.
These steps can be as required repeatedly, to reach the effect of look for clean, conditioning and anti-dandruff.
Embodiment
The non-limiting example of nourishing anti-dandruff shampoo composition of the present invention below.The providing of these embodiment is only used to the object of explanation, can not be interpreted as limitation of the invention, because without departing from the spirit and scope of the present invention, can carry out many changes to the present invention.In these embodiments, unless stated otherwise, all concentration is all percentage by weight.Term used " a small amount of material " refers to those optional materials, as antiseptic, viscosity modifier, pH adjusting agent, spice, pigment etc., the selection of these a small amount of materials is by along with selected changing in order to prepare the physics and chemistry characteristic of special component of the present invention.
Preparation Example I-X V
Described in suitable Preparation Example I-X V, the method for nourishing anti-dandruff shampoo composition is as follows: suitable quantity of water is joined in retort, under slowly stirring, add melon glue and Polyquaternium-10 to disperse, slowly be stirred and heated to 60 ℃ to 80 ℃, then add pH adjusting agent (for example citric acid), Laurel alkyl ammonium sulfate, polyoxyethylene lauryl ether ammonium sulfate, cocamido propyl betaine, fatty monoethanol amide, ethylene glycol bisthioglycolate sodium stearate, acrylic copolymer, phthalic acid amide, disodiumedetate (if using these materials), make these materials disperse rear cooling completely.When being down to 70 ℃ of left and right, temperature successively adds anti-dandruff dose of octopirox and Zinc Pyrithione, after being uniformly dispersed, being cooled to 50 ℃ adds emulsified silicone oil, anti-dandruff Synergistic additives to be uniformly dispersed below, add again antiseptic, pigment, essence etc. to continue to stir, guarantee to obtain uniform mixture.After adding all components, can add as required viscosity modifier and pH adjusting agent, regulate the viscosity of product and pH to arrive suitable degree.Optionally finally can add a small amount of water to supply.
Embodiment I-V
Embodiment VI-X
For comparing experiment, following examples (XI-X V) do not contain octopirox, only contain Zinc Pyrithione (ZPT)
Embodiment XI-X V
Effect Evaluation operation example
For the effect evaluation methodology of embodiment, divide and take sensory evaluation method as main.
Described sensory evaluation method is: by Preparation Example I-X V, issue respectively 60 testers and contrast use.When tester uses shampoo sample, according to identical method hair washing, every kind of shampoo is used two weeks.Tester according to oneself feel mark, wherein antipruritic effect is that time of starting according to head pruritus and the degree of head pruritus are marked, anti-dandruff effect is to mark according to number and the size of dandruff.Standards of grading adopt 7 minutes systems, and 1 minute the poorest, and 7 minutes best, and the higher effect of mark is more good.Various shampoo composite result of use evaluation results are listed in table 1.
Table 1 shampoo composite result of use is evaluated
The evaluation of anti-dandruff and antipruritic effect persistent period:
The sensory evaluation method of the persistent period of described anti-dandruff effect is: by Preparation Example I-X V, issue respectively 60 testers and contrast use.When tester uses shampoo sample, according to identical method hair washing, use continuously surrounding, use weekly twice; Examination person according to oneself feel mark, wherein antipruritic effect and anti-dandruff effect are according to starting to calculate marking of initial head pruritus and initial dandruff with the first day of the 5th week after embodiment.If the first day of the 5th week just starts to itch, just comment 1 part, second day is commented 2 minutes, and with this type of, if start to itch and just comment 7 minutes for the 7th day.The evaluation methodology of anti-dandruff persistent period: just comment 1 minute if the first day of five weeks just starts to occur dandruff, second day is commented 2 minutes, and with this type of, if start to occur for the 7th day, dandruff just comments 7 minutes.
Standards of grading adopt 7 minutes systems, and 1 minute the poorest, and 7 minutes best, and the higher effect of mark is better.Various shampoo composite result of use evaluation results are listed in table 2.
Antipruritic and the anti-dandruff effect persistent period of table 2 shampoo composite is evaluated
Claims (1)
1. contain the shampoo composite of two anti-dandruff dose, its component and content are:
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| CN106572655A (en) * | 2014-06-27 | 2017-04-19 | 朱比兰特生命科学有限公司 | Synergistic antimicrobial composition of zinc pyrithione |
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| EP3344345B1 (en) * | 2015-09-01 | 2020-10-21 | L'Oréal | Composition comprising at least one anionic surfactant, at least one nonionic surfactant, at least one amphoteric surfactant, at least one cationic polymer and at least one amphoteric polymer |
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