KR100777542B1 - Anti-dandruff hair-care cosmetic composition - Google Patents

Abstract

The present invention relates to a hair cosmetic composition for preventing dandruff, characterized in that it contains a hair extract as an active ingredient. In addition to its antibacterial and anti-inflammatory effects on Pityrosporum ovale , which is the causative agent of dandruff, hair extracts have no side effects on the skin, so the hair cosmetic composition containing it as an active ingredient is used to prevent dandruff with itching. It can be used very effectively.

Dandruff * Famox extract * Hair * Cosmetic

Description

Anti-dandruff hair cosmetic composition {Anti-dandruff hair-care cosmetic composition}

The present invention relates to a hair cosmetic composition for preventing dandruff.

In general, dandruff refers to a lump of dead cells of the scalp that are peeled off in the form of hard keratin and come together from sebum, sweat, etc. secreted from the scalp and are considered as a mild form of seborrheic dermatitis and psoriasis. Dandruff occurs physiologically in everyone, so normal dandruff is natural and does not matter. However, an increase in the amount of dandruff that occurs so much that it is noticeable is called dandruff, which is easy to relapse and usually accompanied by itching. Excessive rubbing of the scalp due to dandruff or itching caused by dandruff causes wounds on the scalp or, in some cases, inflammation of the scalp and causes hair loss.

Pyrosporum ovale, the scalp flora, has been known as the main cause of dandruff. There are controversial factors with the claim that Pytylosporum obale is not a direct cause of dandruff, but Shuster et al. Note that the clinical severity of dandruff is closely related to the number of Pytilosporum obale. Phytorosporum obale is known to improve dandruff in the treatment of antimicrobial drugs against pytirosporum obale, and to induce dandruff when artificially inoculating the experimental animal with pytirosporum obale. (S. Shuster. Dandruff, seborrhoeic dermatitis, and Pityrosporum ovale. Cosmet. Toilet. 103 (3): 87, 90, 91 (1988)).

Specifically, the mechanism by which Pytilosporum obale is involved in dandruff development may be seen as a result of the inflammatory response caused by Pytylosporum obale. Phytilosporum obale activates complement (C '), which leads to the release of chemotactic factors such as leukotriene B4, whereby neutrophyls Attraction to this dermis leads to keratinization (ABAckerman and AMKligman. Some observations on dandruff. J. Soc. Cosmet. Chem. 20: 81-92 (1969)).

In addition, phytirosporum obale requires free fatty acids (FFAs) or triglycerides (TGs), which are degradation products of lipids for growth, and lipase or phosphate to produce these substrates. Produces phospholipase. These enzymes also react with unsaturated FFAs, TGs, squalene, cholesterol, and membrane phospholipids present in the scalp to form highly reactive peroxides, which in turn react with membrane phospholipids to produce arachidonic cascades. induces arachidonic cascade, producing intermediates of the inflammatory response and exacerbating the inflammatory response (MMRieger.The arachidonic acid cascade.Cosmet.Toilet. 100 (6): 31-32,34,35,38,40, 43-47, 50, 53 (1985)).

Currently, products such as shampoos for the purpose of alleviating dandruff include zinc pyrithione, pyroctone olamine, and klimbazole, which have antimicrobial activity against Pyrosporum ovale. Climbazole) and Iodo Propynyl Butyl Carbamate. Among these, zinc pyrithione is a representative anti-dandruff raw material and has a good effect on inhibiting scalp sharpening and antifungal, but it is difficult to uniformly disperse in the composition due to water insolubility and high specific gravity (Gene A. Hyde and Mark M. Auerbach, Formulation Technologies for Zinc Pyrithione Antidandruff Shampoos, Cosmetics and Toiletries, 94, 57, April 1979), in particular allergic contact dermatitis caused by zinc pyrithione associated with pustular psoriasis, Am J Contact Dermat. 8, 170, 1997) and environmental toxicity has been reported, which limits the application to high concentrations of hair cosmetics.

Other chemical antimicrobials also suffer from solubility, human safety and environmental toxicity. Currently, tea tree oil is applied to dandruff shampoo because it has antibacterial effect against dandruff bacteria, but the actual antimicrobial effect is difficult to expect dandruff suppression effect when applied to products because MIC exceeds 1000ppm. to be.

In addition, dandruff usually involves itching of the scalp. As a dermatitis that causes itching, such as dandruff, there are atopic dermatitis, which has been reported that histamine and arachidonic acid metabolites are associated with inflammatory mediators. Inflammation of the skin by histamine results in a reaction similar to the action of antigens or compounds 48/80 on mast cells in the skin. In addition to the histamine and basic enzymes already present in mast cells, prostaglandins are involved in the reaction with cyclooxygenase or lipoxygenase. The secretion of perleukotriene and platelet activating factor (PAF) leads to a complex inflammatory response and stimulation of nerve cells, causing itching.

Therefore, there is a need for a hair cosmetic that can effectively prevent dandruff accompanied by itching without side effects on the skin.

Therefore, the technical problem to be achieved by the present invention is to solve the above problems, excellent antimicrobial activity against the cause of dandruff cause bacteria Pityrosporum ovale ( Pityrosporum ovale ) and effective to relieve itching, there is no side effect on the skin can be used safely It is to provide a hair cosmetic composition for preventing dandruff.

In order to achieve the above technical problem, the present invention provides a hair cosmetic composition for preventing dandruff, characterized in that it contains an extract as an active ingredient.

The anti-dandruff hair cosmetic composition according to the present invention preferably further contains 0.001 to 1% by weight of zinc pyrithione based on the total weight of the composition.

Hereinafter, the hair cosmetic composition for preventing dandruff according to the present invention will be described in detail.

Femo is a perennial herb that is 30-60 cm high, with a monocotyledonous lily. The leaves are narrow willow-shaped or row-shaped, and the ends are wound around others. Flowers with bell-colored spots on the ends of the branches. The shape of the scaly stem is called as 'Famo' because it seems to have gathered several shells. Also known as desolation. In Korea, it grows under trees in North Hamgyong Province, South Hamgyong Province, and Yanggang Province. In motion therapy, crusts of scales are peeled off the skin and used to dry in the sun, coughing is working. The scaly stem contains components such as alkaloids, pretilins, fritillins, pritiminins, verticins, apovertins, vertilisin, feminine, femininosides, feminine, feminine, and feminine. . Pretilarin paralyzes the central nervous system of warm-blooded animals, causes respiratory and motor impairments, reduces heart rate, incomplete contractions, and lowers blood pressure. Feminine and Feminoside, a monoglucoside of peminine, lower blood pressure in anesthetized animals. The coughing effect of the femo is known to act on the central nervous system, in particular the respiratory and blood movement centers to relieve breathing and pulse. In motion therapy, it is used for pneumonia, phlegm, pear pesticide, pneumonia, tonsillitis, sore throat, bronchitis, and gugal. Cuts, cuts, insect bites, sometimes applied. It is also used as an inflammatory or fever-reducing medicine (components and use of herbs, written by Janwolseo).

The inventors of the present invention on Pyrosporum ovale, a causative agent of dandruff, found that the extracts of Pamo extract relieved itching without any side effects and showed an excellent antimicrobial effect against Ptyrosporum ovale . It was. Therefore, according to the present invention, when the hair extract is added to the hair cosmetic composition such as shampoo, hair conditioner, hair tonic, hair cream, hair spray, hair mousse, etc., it may have an effect of preventing or alleviating dandruff without any side effects.

Specific examples of the method of extracting hair follicles are as follows.

The hairs are harvested when the surface color starts to appear slightly light in May to June, and removes foreign substances such as soil and dust, and dries them in the shade for 2-3 days. After drying, the seed is removed, and the dried pulp portion is finely crushed and cooled in a 5-fold extraction solvent for 2 days, and then the extract is filtered and concentrated to obtain an extract. At this time, as the extraction solvent, it is preferable to use a solvent such as water, methanol, ethanol, propanol, butanol, glycerol, propylene glycol, 1,3-butylene glycol alone or a mixture of two or more thereof.

In the hair cosmetic composition according to the present invention, it is preferable that the content of the containing hair extract is 0.001 to 10% by weight based on the total weight of the composition. If the content is less than 0.1% by weight it may be difficult to obtain the expected effect, if it exceeds 10% by weight may not show a significant increase in effect by the amount added.

In addition, the anti-dandruff hair cosmetic composition of the present invention preferably further contains 0.001 to 1% by weight of zinc pyrithione based on the total weight of the composition in order to further increase the antibacterial effect. If their content exceeds 1% by weight, the aforementioned side effects may occur. In addition to this, a known anti-dandruff component can be further added within a range not impairing the object of the present invention.

Hereinafter, the present invention will be described in detail with reference to Examples. However, embodiments according to the present invention can be modified in many different forms, the scope of the present invention should not be construed as limited to the embodiments described below. Embodiments of the present invention are provided to more completely explain the present invention to those skilled in the art.

Example of extracting hair

Extraction Example 1

When the surface color began to appear slightly light in May ~ June, the hair was harvested, and foreign matter such as soil and dust was removed and dried in the shade for 2-3 days. After drying, the seed was removed, and the dried pulp portion was finely crushed and cooled in a 5-fold extraction solvent for 2 days, and then the extract was filtered and concentrated to obtain an extract. At this time, ethanol was used as the extraction solvent.

Experimental Example 1-Antimicrobial Effect of Extracts

The antibacterial effect of tea tree oil, which is used in anti-dandruff products, was tested against Pytilosporum obale, the causative agent of dandruff, and the paper disc method. ) And Minimum Inhibitory Concentration (MIC) measurement were performed in parallel.

The paper disc method is as follows.

The bacterial solution of Pytylosporum obale was previously coated on a solid medium and dried, and then the size of the growth-lowering ring was formed after incubating with the extract on a paper disc and placing it on the medium. Each sample was dissolved in 70% ethanol solvent at a concentration of 5%, and then 40 µl was added to an 8 mm paper disk.

In addition, the MIC measurement method is as follows.

After diluting each sample in a liquid medium at regular concentration intervals, the inoculation was inoculated with Pytylosporum obale, and the minimum concentration of inhibiting bacterial growth was determined by observing the growth of the cells by sample concentration.

As a result, the paper disc method showed that the diameter of the growth inhibitory ring of the extract was 50 mm, slightly lower than 60 mm of zinc pyrithione, but much larger than 15 mm of tea tree oil.

MIC measurements showed that the MIC of the extract was 20-40 ppm. This is more than 10 times lower than 2-4 ppm of zinc pyrithione, but the MIC of tea tree oil is much better than 1000ppm.

Referring to the above experimental results, the extract was shown to have a lower antimicrobial activity than zinc pyrithione, a chemical synthetic antimicrobial agent, but the antimicrobial natural product was superior to the tea tree oil currently applied to the product. Considering that the extract can increase the amount of use as a natural extract is safe for the human body, there will be sufficient useful value as an anti-dandruff ingredient.

Experimental Example 2-Anti-inflammatory Effect of Extracts

In order to confirm the anti-inflammatory effect in addition to the antimicrobial effect, the extract was tested for the inhibitory effect of histamine as follows.                     

Remove hair from the back of the Sprague-Dawley rats (SD rat, Sprague-Dawley rats) at 5 to 6 weeks of age with a clipper, then randomly divide the back hairs into 4 parts, and then saline to 0.5% in the two right positions. 50 µl of the extract was dissolved in the injection, and the left side was injected with the same amount of normal saline as a control. Subsequently, 1 hour after the injection of the extract, a 50 μl of histamine dissolved in 0.1% in saline was injected into the skin, and 50 μl of 1% Evans blue solution was injected into the tail vein. 30 minutes after the injection of Evans Blue solution, skin was removed from the back and the diameter of the circle where Evans Blue was exuded into the tissue was measured to evaluate the inhibitory effect of the extract of Pamo extract on histamine-induced inflammation. . Table 1 shows the diameter of the circle (mm) extruded Evans blue into the tissue.

Referring to Table 1, the greater the effect of inhibiting inflammation caused by histamine, the smaller the diameter of the Evansblue circle exuded into the tissue. It was reduced and the effect appeared to be superior to steroid preparations.

Hereinafter, the preparation of dandruff cost hair cosmetic composition containing the hair extract, and looked at their anti-dandruff effect.

Examples 1 and 2

After the addition of 30% sodium lauryl sulfate, 30% polyoxyethylene lauryl sulfate, palm oil fatty acid diethanolamide, propylene glycol and a balm extract in water according to the composition ratios shown in Table 2, the temperature of the mixture reached 60 ° C. Warmed to uniform dissolution and cooled to 40 ° C. Subsequently, the pigment | dye (blue No. 1), the paraoxybenzoic acid ester, a fragrance | flavor, and citric acid were mixed and cooled, and the shampoo was manufactured.

Comparative Examples 1 to 4

Shampoo was prepared in the same manner as in Example, except that the extract was not added, and changed to the ingredients and contents shown in Table 2 below.                     

The efficacy of the shampoos prepared according to the above Examples and Comparative Examples was evaluated through the following test.

<Evaluation of antimicrobial activity against pitilosporum obale>

5, 1, 0.5, 0.1, 0.05 and 0.01% by weight of the shampoos of Examples and Comparative Examples were added to the liquid medium for the growth of dandruff, inoculated with phytirosporum obale and incubated for 2 days, followed by Minimal Bactericidal Concentration (MBC) was obtained and the results are shown in Table 3.

Referring to the results of Table 3, the shampoo formulation containing the extract was shown to have an excellent antimicrobial activity against phytirosporum obale, a causative agent of dandruff, when zinc pyrithione, an anti-dandruff ingredient, was additionally used ( Example 2 It can be seen that the effect is further improved. This is the result of the antimicrobial effect is much improved than the example using the tea tree oil and zinc pyrithione (Comparative Example 4).

<Measuring Decrease Rate>

Ten men and women with relatively high dandruff were selected to use the shampoos of Examples and Comparative Examples for 1 month each. Before the start of the test, the weight of the dandruff collected by shampooing with a conventional shampoo and accumulating dandruff accumulated for 3 days and the weight of the dandruff collected every 3 days with the shampoo of Examples and Comparative Examples and the weight of dandruff accumulated 3 days after the end of the test were compared. Evaluated.

At this time, the collection of accumulated dandruff is to have the experienced tester wash the scalp of the test subjects using about 5 g of the sample, and then rinse with about 2 to 3 liters of water, and then wash the washed water with an 800 micro pore filter medium. The dry weight of the dandruff on the filter medium was measured, and the dandruff reduction rate was obtained by the following equation, and the results are shown in Table 4.

Reduction rate of dandruff (%) = [(weight of dandruff before start of test (mg)-weight of dandruff after start of test (mg)) / weight of dandruff before start of test (mg)] × 100

Referring to Table 4, it was shown that the shampoo containing the fem extract according to the present invention is superior to the rate of dandruff reduction than conventional shampoos or shampoos containing tea tree oil (Comparative Examples 1 and 3). In addition, the swallowing of Example 2, which was added simultaneously with the femo extract and zinc pyrithione, showed a higher dandruff reduction rate than the shampoo containing zinc pyrithione and teatri oil alone (Comparative Examples 2 and 4). Can be.

<Evaluation of Anti-dandruff and Itching Reduction>

Ten random men and women who usually feel itching are randomly selected, and the shampoos of Examples and Comparative Examples are used once every two days for 8 weeks for 8 weeks. The average values are shown in Tables 5 and 6 below.

(Dandruff prevention criteria)

Anti dandruff effect is very good: 5

Good anti-dandruff effect: 4                     

Anti-dandruff effect is normal: 3

Has some anti-dandruff effects: 2

No anti-dandruff effect: 1

(Itching Reduction Effect Criteria)

Itching effect is very good: 5

Itching effect is good: 4

Itching effect is moderate: 3

Itching effect is slightly reduced: 2

No itching effect at all: 1

Referring to the results of Tables 5 and 6, the anti-dandruff effect and the itching reduction effect when using the shampoo containing the fem extract according to the present invention is superior to the conventional shampoo or shampoo containing tea tree oil (Comparative Examples 1 and 3). Appeared. In addition, the anti-dandruff effect of Example 2, which was added simultaneously with the femo extract and zinc pyrithione alone, or a shampoo containing zinc pyrithione and teatri oil simultaneously (Comparative Examples 2 and 4) and It can be seen that the effect of reducing itching was very excellent.

In this way, the extract of the hair extract is not only excellent antimicrobial activity against the cause of dandruff phytirosporum obale, but also excellent anti-inflammatory action, there is no side effect on the skin, and the hair cosmetic composition containing it as an active ingredient also reduces dandruff and itching It was confirmed that is very excellent. Therefore, the hair cosmetic composition such as shampoo containing the hair extract can be used very effectively to prevent dandruff.

Claims (4)

An anti-dandruff hair cosmetic composition comprising water, methanol, ethanol, propanol, butanol, glycerol, propylene glycol and 1,3-butylene glycol as an active ingredient. The anti-dandruff hair cosmetic composition according to claim 1, wherein the dry weight of the extract is 0.001 to 10% by weight based on the total weight of the cosmetic. delete The anti-dandruff hair cosmetic composition according to claim 1, further comprising 0.001 to 1% by weight of zinc pyrithione, based on the total weight of the composition.