KR101832501B1 - Composition for anti-dandruff - Google Patents

Abstract

The present invention relates to an anti-dandruff scalp composition comprising an extract of Rhododendron japonica and at least one extract selected from the group consisting of Gilchuan, Samam, Perception and Sanjuk Leaves. The composition of the present invention has excellent anti-dandruff effect . ≪ / RTI >

Description

Composition for anti-dandruff < RTI ID = 0.0 >

The present invention relates to an anti-dandruff scalp composition comprising an indigo flower extract and at least one extract selected from the group consisting of Gilchuan, Sambrook, The present invention relates to an anti-dandruff scalp composition which has been experimentally proved to be superior in its effect even when there is no side effect including a crust extract as an active ingredient.

Dandruff is a kind of dermatologist who has fat or dust on the keratin that comes off naturally from the skin surface of the hair of the head of the papilloma.

As scalp, new scalp is created and replaced like hair. It replaces new cells about once a month at a faster rate than hair. In a healthy scalp, the cells of the horny layer (or stratum corneum) are quickly replaced with new keratinocytes as they collapse to an invisible small size. However, it is called dandruff that the excess keratinocyte is formed so that the mass of keratinocyte clusters so that the keratinocyte clusters are visible and peeled off from the scalp.

Dandruff is more common in males than females, and dandruff is rare in children under 10 years, but it increases during infancy and childhood and occurs very commonly in puberty.

Psoriasis and seborrheic dermatitis, similar to dandruff, are similar to dandruff, which is similar to dandruff and is very confusing. First, psoriasis can occur throughout the body, whereas dandruff can occur only in the scalp, unlike psoriasis or seborrheic dermatitis. Seborrheic dermatitis occurs most often in the seborrheic areas of the body, especially in the face. Psoriasis and seborrheic dermatitis are accompanied by inflammatory reactions such as erythema, but dandruff is completely independent of the inflammatory response.

There are various causes of the occurrence of dandruff, first, there is an increase in sebum secretion. Malassezia which is presumed to be the main cause of dandruff Microorganisms in the genus use fatty acids to exfoliate the exogenous fatty acids required by the skin. Thus, in order to obtain the required fatty acid, sebum production is increased and secreted, and sebum is excessively secreted by such a mechanism, and keratinocytes are clustered into a mass, resulting in dandruff. In addition, the action of free fatty acids produced by lipase degradation by lipase enzyme can be considered as one of the causes. The sebum secreted from the skin is decomposed by the lipase enzyme to form free fatty acid, which is known to directly or indirectly induce scalp irritation and skin damage, resulting in dandruff. This process is called a fat-splitting mechanism.

The most important factor is the action by microorganisms. mainly Malassezia restricta or Malassezia globosa is found to be twice as many as the amount found in normal scalp in patients with dandruff.

Another cause of scalp And increased cell division. This means an increase in cell division due to metabolic abnormalities not caused by enzymes and fatty acids.

Another cause is abnormal keratinization (Parakeratosis), which is caused by the enzyme keratinization, and the keratin cells are overproduced, leaving nuclei in the stratum corneum of the epidermis, resulting in incomplete keratinization and dandruff.

Other factors include stress, environmental factors, food factors, and genetic factors.

Despite these various causes, currently available anti-dandruff products tend to inhibit the growth of dandruff and approach to mitigate dandruff and use antibacterial components for this purpose.

These ingredients include, but are not limited to, Zinc Pyrithione, Selenium Sulfide, Piroctone Olamine, Cilmbazole, Salicylic acid, Ketoconazole, Coal Tar Corticosteroids, Colloid Sulfur, Selenium disulfide, and the like.

However, most of these anti-dandruff agents are characterized by strong sterilizing power, and most of them have side effects or toxicity, so that it is difficult to use more than a certain amount. Therefore, the content is also regulated in the raw materials described in the laws and regulations of domestic pharmacists.

Therefore, in order to minimize toxicity and side effects, the present invention has been made to prepare anti-dandruff compositions for natural herbal medicines. By normalizing the scalp by the principle of oriental medicine not anti-dandruff effect limited to antibacterial function, Mitigate the occurrence.

From the viewpoint of oriental medicine, it is considered that the skin is dried by heat in the body and the keratinocyte is excited by the skin, and it is considered that it is a better condition for the growth of the germ by heat.

Therefore, treatment of dandruff from this herbal viewpoint approaches to cool the fever, relieve inflammation, and wash the area.

In view of the above, the inventors of the present invention have selected effective natural extracts for each cause and found that they exhibit excellent dandruff performance by combination of these extracts, thus completing the present invention.

It is an object of the present invention to provide an anti-dandruff scalp composition which is excellent in anti-dandruff effect without side effects including an indigo flower extract and at least one extract selected from leaves of Ganoderma,

In one embodiment of the present invention, an indigo flower extract; And an extract of at least one selected from the group consisting of Ganoderma, Ganoderma, Sephadex and Ganoderma lucidum.

In one embodiment of the present invention, the extract comprises at least one extract selected from water extracts, water extracts and supercritical extracts using an extractant or water through an organic solvent using an extraction solvent, ; Lower alcohols of methanol, ethanol, 1-propanol, isopropyl alcohol or butanol; Polyhydric alcohols such as glycerol, ethylene glycol, propylene glycol or 1, 3-butylene glycol; And hydrocarbon-based solvents such as petroleum ether, methyl acetate, ethyl acetate, benzene, hexane, methylene chloride, diethyl ether, dichloromethane or chloroform.

In addition, when extracting, the amount of the extraction solvent added is preferably 5 to 20 ml per 1 g of the dry weight of the natural material. Extraction conditions of the natural materials may include extraction by immersion for 1 to 7 days at room temperature or extraction for 1 to 5 hours at a temperature of 50 to 95 ° C, but not limited thereto, All of the methods can be applied. The natural products can be extracted by cooling the extracts with 70% ethanol for a predetermined period of time at room temperature and filtering the extract.

In one embodiment of the present invention, the extract of Rhododendron japonica, Gamgang, Samyang, Crataegi or Crataegi leaves contains 0.0001 to 50% by weight, preferably 0.001 to 20% by weight based on the total weight of the composition . If the amount is less than 0.001% by weight, the anti-dandruff effect is insignificant, and when the concentration is higher than 50% by weight, the application of the form is difficult, which is disadvantageous.

In one embodiment of the present invention, there is provided a scalp topical dandruff agent which can be applied to scalp in the form of a solution, cream, ointment, paste, aerosol, gel, or wax containing a composition as described above.

In one embodiment of the present invention, there is provided a cosmetic composition which can be applied to hair in the form of a shampoo, rinse, ampoule, or treatment containing the composition.

In addition, the composition of the present invention may be supplemented with auxiliary ingredients such as a moisturizing agent, a hair firming agent, a hair restorer, a scalpel, a refreshing agent and an antistatic agent for imparting additional functions in consideration of the characteristics of the hair, But is not limited thereto. These auxiliary ingredients can be used within the range to maintain the formulation without interfering with the effect of the active ingredient.

The use of the composition according to the present invention has an excellent anti-dandruff effect, and the effect of the natural extract contained in the composition makes it possible to cool the scalp, soothe the inflammation, clean the scalp, And thus it has an advantage of exhibiting excellent anti-dandruff effect by normalizing the scalp.

The present invention will be described in more detail as follows.

The rhizome of the present invention is a flower bud of Lonicera japonica Thunberg. This medicine is a small rod or funnel-shaped bud, often mixed with lips and flowers, 15 ~ 35mm in length. The outer surface is white to yellowish brown. The magnifying glass shows a light brown hairs and five stamens. The flower of an indigo flower has an unusual direction, the taste is sweet and a little sweet. Pharmacological actions include antimicrobial action, antiviral action, antifungal action, convergent action, and diuretic action. The main efficacy is to treat fever by treating fever with fever and poisoning with fever (detoxification). The major components are inositol, luteolin, and tannin.

Another major constituent of the present invention is Gilyeong, which is also called Giligyeong, and is obtained by removing the root of Platycodon grandiflorum A. De Candolle as it is. The drug is irregularly elongated, fusiform or conical, sometimes with branches, and the outer surface is grayish brown, pale brown or white. The main muscle is 10 ~ 15cm long, now 1 ~ 3cm. There is a slight smell and there is no taste at first, but later it is scratched. This medicine is gray-brown, hard, 5cm in length, 1cm in diameter, and should have a high saponin content. The pharmacological action is the gadam action, the vinegar action, the anti-piceal germ action (anti-bacillus bacteria action), and the efficacy has the action goddock (肺 祛 痰), drainage (drainage) action. The major components are Platycodin A, Platycodin C, Platycodin D1, Platycodin D2, Polygalacin D1, Polygalacin D2, Betulin, Inulin ), And phytosterol.

Another major constituent of the present invention, the ginseng, is Adenophora triphylla var. It is the root of the japonica Hara and the copulatory plants (bellflower and Campanulaceae). It is a perennial plant, 50-100cm tall, with hairs all over and roots white and thick. Leaflet is long, almost circular. Leaves are horn or ovate, elliptical or ovate, petiole is short or absent, both ends are sharp, and edges have double sawtooth. Sex is faint, taste is bitter. The main ingredients are essential oil and saponin, and the efficacy is the abolition of gyeoljeoljeong (肺血 止血), Yang Hyosungjin (养胃 生 津), goddam (祛痰), gogal (口渴) is.

Another major constituent of the present invention is the crust cut into unripe fruit of Citrus aurantium Linne in two. This medicine has a certain direction and the taste is a little bit wider. The main ingredients are limonene, linalool, poncirin, naringin, and the properties are fair.

Another major constituent of the present invention, Saja boreails (Hack.) Mak., Is a leaf of Sasa borealis (Sasa boreales). It has been known to be effective against hypertension, diabetes, chronic hepatitis and gastric ulcer.

Hereinafter, the present invention will be described in more detail with reference to the following examples and experimental examples. However, these examples and experimental examples are provided only for the understanding of the present invention, and are not intended to limit the scope of the present invention.

Example  1. Preparation of extract

First, the impurities were filtered out from alfalfa flowers, Gyungyang, Samshan, crustacean, and ganjuk leaf, and about 4 to 10 times of ethanol and purified water according to the criteria of the Korean Pharmacopoeia were added thereto, followed by cooling at room temperature for 5 days. The extracted extract was filtered using Wattman # 3 filter paper, and the extracted extract was completely evaporated at 45 ° C using a vacuum concentrator to prepare a dried extract.

Example  2 to 4. Antidandruff  Preparation of composition

The anti-dandruff compositions were prepared according to the conventional methods known in the art from the indomethacin flowers, Gyungyang, Samshan, crustacean, and mountain juice leaf extracts prepared in Example 1 as described in the following Table 1.

Comparative Example  1 to 4

Comparative Examples 1 to 4 were prepared according to the conventional methods known in the art in a composition not containing both indigo flower and Gakugei, ginseng, crust, and mountain juice leaf extract as shown in Table 1 below.

Manufacturing Component (% by weight) Comparative Example 1 Example 2 Example 3 Example 4 Sodium lauryl sulfate 10 10 10 10 Cocamidopropyl betaine 3 3 3 3 Carboxyl vinyl polymer 0.3 0.3 0.3 0.3  Polyquaternium-10 0.2 0.2 0.2 0.2 incense 0.7 0.7 0.7 0.7 Methyl paraben 0.2 0.2 0.2 0.2 Cetyltrimethylammonium chloride 0.1 0.1 0.1 0.1 Indigo flower extract 0 5 3 One Gwangyang extract 0 5 3 One Ginseng extract 0 5 3 One Crust extract 0 2 One One Ganjuk Leaf Extract 0 2 One One Purified water Remaining amount Remaining amount Remaining amount Remaining amount

Experimental Example  1. Using dandruff Antisstimulus  evaluation

The anti-dandruff effect was evaluated by comparing the anti-dandruff power of dandruff, Malassezia globosa, and Malassezia restricta, which are known to cause dandruff, A method of evaluating antidinocyclosis is used.

In the present invention, anti-dandruff test was performed on dandruff, Malassezia globosa and Malassezia restricta, using indocyanine flower, Gyungyang, samsang, crustacea, and mountain juice leaf extract obtained according to Example 1.

Malassezia globosa and Malassezia restricta are known to induce dandruff. It is known that by-products and fungi produced during the process of using scalp sebum cause dandruff. Therefore, anti-dandruff can be deduced by evaluating the antimicrobial activity against two species.

After inoculation of the two species into the modified dixon agar medium, 20ul of the diluted sample was dropped on a paper disc and cultured at 30 ° C for 3 to 7 days. The size of the clear zone generated was measured to determine the anticlastic activity Were measured.

Samples prepared according to Comparative Example 1 and Example 2 were used in the experiments. Each sample was diluted to a concentration of 10% and used in the experiment. The results are shown in Table 2 below.

Comparative Example 1 Example 2 Measure 1 0 mm 4.5 mm Measure 2 0 mm 4.3 mm Measure 3 0 mm 4.2 mm Average 0 mm 4.3 mm

As shown in the results of Table 2, it was confirmed that the clear zone showing the anti-dandruff power was widely exhibited in Example 2 containing Rhodophylla and Gakyung, Samam, It was confirmed that it did not show anti-dandruff power.

As a result, it was confirmed that the samples containing indigo flower and Gakyung, Samam, crust, and japanese leaf extract showed anti - dandruff power and exhibited anti - dandruff effect.

Experimental Example  2. Clinical trial for dandruff patients

To investigate the effect of dandruff on patients, clinical trials were conducted on patients with dandruff.

As subjects, subjects who had dandruff among adult men and women over 20 years old were shampooed once a day for 5 persons per each sample, and they were performed for at least 2 weeks to 1 month.

The results of the evaluation of the effects of the dermatological lesions were evaluated in five steps according to the following evaluation scale (Table 3). The results are shown in Table 4 below.

step Visual judgment Subjective symptoms One It got worse. It got worse. 2 There is no change. There is no change. 3 Slightly improved Slightly improved 4 Improved. Improved. 5 Remarkably improved Remarkably improved

division Visual judgment Subjective symptoms Comparative Example 1 2.0 2.1 Example 2 4.5 4.8 Example 3 4.1 4.3 Example 4 3.8 4.0

As shown in the results of Table 4, it was confirmed that Examples 2 to 4 containing the extract showed superior dandruff power in visual examination and subjective symptoms than in Comparative Example 1 which did not contain the extract.

In addition, during the period of use in clinical trials, no adverse effects were found in all subjects and it was found to be safe for human body.

Compared with the samples containing the extracts of Indong flower, Gyungyang, Samgam, Crustacea, and Sanjukji leaf, the anti-dandruff test showed better anti-dandruff power than the samples containing no extract, In one clinical trial, it showed very good effect.

Therefore, it can be seen that a composition containing Rhodiola giganta and Gakyung, Samam, Crataegi, and Yamana japonica leaf extract exhibits excellent anti-dandruff effect while being attracted to human body.

Example  5 to 7. Preparation of hair and scalp application compositions in shampoo form

A shampoo type hair and scalp application composition containing an indigo flower and a Gakyung, a ginseng, a crust, and a mountain juice leaf extract obtained according to Example 1 was prepared.

Manufacturing Component (% by weight) Example 5 Example 6 Example 7 Sodium lauryl sulfate 10 10 10 Cocamidopropyl betaine 3 3 Carboxyl vinyl polymer 0.3 0.3 0.3  Polyquaternium-10 0.2 0.2 0.2 incense 0.7 0.7 0.7 Methyl paraben 0.2 0.2 0.2 Cetyltrimethylammonium chloride 0.1 0.1 0.1 Indigo flower extract 5 3 One Gwangyang extract 3 One 0.5 Ginseng extract 3 One 0.5 Crust extract 2 One 0.5 Ganjuk Leaf Extract 2 One 0.5 Purified water Remaining amount Remaining amount Remaining amount

Example  8 to 9. Preparation of rinse-type hair and scalp application composition

A rinse-type hair and scalp application composition containing indomethacin, ganoderma, ginseng, crust, and mountain juice leaf extract obtained according to Example 1 was prepared.

Manufacturing Component (% by weight) Example 8 Example 9 Cetyl alcohol 2 2 Stearyl alcohol 2.5 2.5 Behenyl alcohol 0.5 0.5 Spices 0.4 0.4 Silicone emulsion 0.4 0.4 Cyclomethicone 1.0 1.0 Dimethyl distearyl ammonium chloride 0.1 0.1 Citric acid Amount adjustable to pH 3-7 Amount adjustable to pH 3-7 Indigo flower extract 5 3 Gwangyang extract 5 3 Ginseng extract 5 3 Crust extract One 0.5 Ganjuk Leaf Extract One 0.5 Purified water Remaining amount Remaining amount

Example  10. Preparation of compositions for application to hair and scalp in ampoule form

An ampoule-shaped hair and scalp application composition containing an indigo flower, Gakgye, Samgam, crust, and mountain juice leaf extract obtained according to Example 1 was prepared.

Manufacturing Component (% by weight) Example 10 ethanol 30 Propylene glycol 20 1,3-butylene glycol 10 Cetyltrimethylammonium chloride 3 Dimethyl distearyl ammonium chloride 0.1 Lauryl alcohol 3 Myristyl alcohol 5 Cetyl alcohol One incense 0.5 dyes Proper amount Indigo flower extract One Gwangyang extract One Ginseng extract One Crust extract 0.3 Ganjuk Leaf Extract 0 Purified water Remaining amount

Example  11-12. tonic  Of hair and scalp application composition

A tonic hair and scalp application composition comprising the indomethacin, the ginseng, the ginseng, the crust, and the mountain juice leaf extract obtained according to Example 1 was prepared.

Manufacturing Component (% by weight) Example 11 ethanol 40 Propylene glycol 10 Polysorbate 20 5 incense 0.5 dyes Proper amount Indigo flower extract 0.5 Gwangyang extract 0.5 Ginseng extract 0.5 Crust extract 0.1 Ganjuk Leaf Extract 0.1 Purified water Remaining amount

While the present invention has been described with reference to exemplary embodiments, it will be understood by those skilled in the art that various changes may be made and equivalents may be substituted for elements thereof without departing from the scope of the invention. You will know. In addition, many modifications may be made to adapt a particular situation and material to the teachings of the invention without departing from the essential scope thereof. Accordingly, it is intended that the invention not be limited to the particular embodiment disclosed as the best mode contemplated for carrying out this invention, but that the invention be construed as including all embodiments falling within the scope of the appended claims.

Claims (7)

An anti-dandruff scalp composition comprising indomethacin, indigo flower, Gakyung, Samyang, crustacean and ganoderma lucidum extract. The method according to claim 1,
Wherein the extract comprises at least one extract selected from water extracts, water extracts, and supercritical extracts using an extracting solvent or water using an extracting solvent using an extracting solvent. 3. The method of claim 2,
The extraction solvent may be purified water; Lower alcohols of methanol, ethanol, 1-propanol, isopropyl alcohol or butanol; Polyhydric alcohols such as glycerol, ethylene glycol, propylene glycol or 1, 3-butylene glycol; And a hydrocarbon-based solvent of petroleum ether, methyl acetate, ethyl acetate, benzene, hexane, methylene chloride, diethyl ether, dichloromethane or chloroform. The method according to claim 1,
Wherein the extract of Angelica keiskei koidz., Gakkyu, Seisham, Seikaku or Yamaku leaves contains 0.0001 ~ 50 wt.% Based on the total weight of the composition. The method according to claim 1,
Wherein the extract of Angelica keiskei koidz., Gakkyu, Samyang, Crataegi, or Seishi leaves comprises 0.001 to 20% by weight based on the total weight of the composition. A topical topical anti-dandruff agent, which can be applied to scalp in the form of a liquid, cream, ointment, paste, aerosol, gel, or wax form containing a dandruff scalp composition according to any one of claims 1 to 5 Dandruff A cosmetic composition which can be applied to hair of shampoo, rinse, ampoule, or treatment type comprising the anti-dandruff scalp composition according to any one of claims 1 to 5.