CN115337212A

CN115337212A - Composition for relieving itching, removing dandruff and controlling oil and application thereof

Info

Publication number: CN115337212A
Application number: CN202111274413.5A
Authority: CN
Inventors: 王红叶; 张艳; 王月亮; 张海静; 齐若男
Original assignee: Bohui Meicui Bioengineering Technology Guangdong Co ltd
Current assignee: Bohui Meicui Bioengineering Technology Guangdong Co ltd
Priority date: 2021-10-29
Filing date: 2021-10-29
Publication date: 2022-11-15

Abstract

The invention relates to the field of C02F1/00, in particular to a composition for relieving itching, removing dandruff and controlling oil and application thereof. The invention adopts 0.1-23% of conditioner, 1-10% of zinc compound, 1-12% of amino acid compound, 0.5-8% of plant extract, 30-54% of surfactant, 0.8-6.0% of functional assistant and the balance of solvent to prepare the composition for relieving itching, removing dandruff and controlling oil, which has high safety, good stability, mild, slow and moisture-keeping effects, and excellent oil-controlling, bacterium-inhibiting and dandruff-removing effects.

Description

Composition for relieving itching, removing dandruff and controlling oil and application thereof

Technical Field

The invention relates to the field of A61K8/00, in particular to a composition for relieving itching, removing dandruff and controlling oil and application thereof.

Background

The existing hair washing and caring products mostly adopt chemicals with antibacterial property to clean the scalp, but chemical agents with antibacterial property often have the problems of large irritation to the skin and easy damage to the skin cuticle when acting on the scalp and hair bundles, and can cause vicious circle to the scalp in the using process.

Chinese patent CN105232410A discloses an oil-controlling and hair-loss-preventing shampoo product and a preparation method thereof, wherein a shampoo product for controlling oil and hair loss and preventing hair loss is prepared by using plant extracts as main raw materials and matching hydrolyzed collagen, magnolia flower oil and the like, but the shampoo product contains a preservative which has irritation to scalp and is composed of methylchloroisothiazolinone and methylisothiazolinone, and the balance of safety and efficacy cannot be realized. Chinese patent CN107126389A discloses an amino acid shampoo product and a preparation method thereof, which mainly adopts plant extract, amino acid surfactant, hyaluronic acid, water-soluble grease and shampoo auxiliary materials as raw materials to prepare the amino acid shampoo product which has good hair moisturizing and water locking effects, is rich in various amino acid essence substances and plant extract essences and can mildly maintain the environment of hair and scalp, but the compatibility, the dispersibility and the system stability of each component in the formula can not be effectively ensured.

Therefore, the composition for relieving itching, removing dandruff and controlling oil, which has high safety, good stability, mild, comfortable and moisturizing effects, and excellent oil control, bacteriostasis and dandruff removing effects, has important practical research and application significance.

Disclosure of Invention

The invention provides a composition for relieving itching, removing dandruff and controlling oil on one hand, and the preparation raw materials at least comprise the following components in percentage by weight: 0.1-23% of conditioner, 1-10% of zinc compound, 1-12% of amino acid compound, 0.5-8% of plant extract, 30-54% of surfactant, 0.8-6.0% of functional assistant and the balance of solvent.

The main research and development idea of the existing hair washing and caring products is to adopt chemicals with antibacterial property to clean the scalp. However, chemical agents having antibacterial properties often cause problems of high irritation to the skin and easy destruction of the horny layer of the skin when they act on the scalp and hair bundles, and rather, they cause a vicious circle in the scalp during use. In order to enable the obtained composition to have certain mildness and comfort and simultaneously achieve the effects of controlling oil, inhibiting bacteria and removing dandruff, as a preferable technical scheme, the conditioner is selected from one or a combination of more of self-imidazole di (hydroxyethyl sulfonate), pyrrolidone ethanol ammonium salt, 10-hydroxydecanoic acid, chitosan quaternary ammonium salt and organosilicon quaternary ammonium salt; preferably, the conditioner is a combination of a hexidine di (hydroxyethyl sulfonate), a pyrrolidone ethanol ammonium salt and 10-hydroxydecanoic acid, the applicant unexpectedly discovers that growth of microorganisms such as pityrosporum ovale and the like hidden in a scalp environment can be effectively inhibited by adopting the hexidine di (hydroxyethyl sulfonate), the pyrrolidone ethanol ammonium salt and the 10-hydroxydecanoic acid as the conditioner, and simultaneously, the compound component has strong osmosis on the surface layer of the skin and can remarkably reduce secretion of skin grease, so that interference of grease secretion on the action of antibacterial components is reduced, acne and pimple and other acne-like pathological changes caused by grease secretion are inhibited, skin pores are effectively dredged after use, the metabolism activity of stratum corneum is improved, the flora balance of the skin inside the scalp is regulated, the composition cleans the scalp and controls hair bundles, and the antibacterial oil effect is improved; more preferably, the weight ratio of the hexmidine di (isethionic acid) salt, pyrrolidone ethanol ammonium salt and 10-hydroxydecanoic acid is (0.1-2): (3-10): (2-15), the composition has no irritating effect on skin after contacting skin, has good astringency characteristic while keeping high antibacterial activity, improves local tolerance of skin mucosa to the composition, improves the safety of the composition by using a conditioner with a specific proportion, avoids damage of skin cuticle after using a chemical reagent, improves the effects of relieving itching, controlling oil and removing dandruff for skin, improves the comfort and safety of the composition, and can be gently and efficiently applied to scalp and hairlines.

The CAS number of the hexmidine di (isethionate) salt is 659-40-5, purchased from Shanghai-derived PhylloBiotechnology, inc.; the CAS number of the pyrrole ketamine ethanol ammonium salt is 68890-66-4, and the pyrrole ketamine ethanol ammonium salt is purchased from Hebeijin chemical engineering Co., ltd; the CAS number of the 10-hydroxydecanoic acid is 68890-66-4, which is purchased from Bailingwei science and technology Limited, beijing.

As a preferred technical scheme, the plant extract is selected from at least one of mint extract, linseed extract, black sesame extract and aloe extract; preferably, the plant extract is a mint extract; the mint extract is menthol extracted from the leaves and stems of mint, is a cyclic monoterpene compound, has strong anti-inflammatory and itching relieving effects, also has the effect of eliminating fungal infection, and is an effective raw material for improving the cleaning power of shampoo products. Menthol, however, has non-negligible irritation to the skin, readily stimulates nerve endings during use, causes a cold reflex, and reduces the sensitivity of the tissue to vasoconstrictive changes.

The CAS number of the menthol is 89-78-1, and the menthol is purchased from Jiangxi Baicao pharmaceutical industry Co.

In order to improve the moisture retention of the composition, reduce the tendency of cold feeling of the skin after the menthol is used and optimize the construction of a skin tissue barrier, as a preferred technical scheme, the zinc compound comprises PCA zinc and zinc oxide; according to the invention, the PCA zinc and the zinc oxide are added into the composition to act together, so that a water-locking protective film can be formed on the horny layer of the skin, and a buffer layer is provided for the effect of the menthol on the skin, thereby reducing the irritation of the skin after contacting the composition. However, in the course of the research it was found that the addition of zinc oxide resulted in a composition with a certain moisture absorption and a certain risk of local dehydration of the skin during the actual test. The present invention unexpectedly found that when the weight ratio of zinc PCA to zinc oxide was (2-7): (0.1-1), especially when the adopted zinc oxide is nano zinc oxide with the diameter of 30 +/-10 nm, the antibacterial property and the moisture retention of the composition can reach higher levels, no irritant cool feeling exists in the using process, and the conditioning effect and the sensory experience feeling of the composition are both considered.

The CAS number of the PCA zinc (pyroglutamic acid zinc) is 15454-75-8, the product purity is more than 98.0%, and the product is purchased from Shanghai front derivative science and technology Co., ltd; the nano zinc oxide has a CAS number of 1314-13-2 and a product number of Z112847, and is purchased from Shanghai Aladdin Biotechnology, inc.

As a preferable technical scheme, the amino acid compound is at least one selected from polylysine, polyglutamic acid and polyglycine; preferably, the amino acid compound is polylysine, and the polylysine is polypeptide with a bacteriostatic effect, is a natural biological metabolic product, and has good bactericidal capacity, excellent preservative property and thermal stability, and strong moisture absorption capacity.

The CAS number of polylysine is 28211-04-3, purchased from Topson Biotech, inc., beijing.

The action effect of the hair washing and caring product is greatly influenced by the retention time of the effective components on the surfaces of the scalp and hair bundles, and the action effect is enhanced along with the increase of the retention time. However, in the hair cleaning process, components such as conditioner and the like are easy to be washed by water quickly, and the retention time on the scalp and the hair is difficult to maintain; the retention time of the functional components can be effectively prolonged by adding the oily medium, but the scalp is easily greasy and heavy; in the process of researching, the invention discovers that when the weight ratio of the conditioning agent to the zinc compound to the amino acid compound is (9-18): (2-8): (3-10), the obtained composition can stay on the surface layer of the skin for a proper time, and the composition has certain washing resistance, probably because polymer molecular chains with specific structures carry small-molecule functional substances, and the attaching degree of the polymer molecular chains with specific structures to the surface of the skin is obviously improved; meanwhile, the composition improves the destruction capability of the composition on the membrane structure of microorganisms under the condition, further inhibits the physiological activity of harmful microorganisms, and promotes the regulation and control of the balance of scalp flora; meanwhile, the composition can endow the scalp and hair bundles with excellent use experience feeling under the coordination of the specific plant extracts, the scalp skin is fresh and breathable after use, the hair is light and smooth, and the hair is deeply moistened and maintained from the hair to the hair root while dirt is cleaned.

Although the antibacterial and anti-inflammatory effects of the composition are improved by adding the conditioner with antimicrobial activity, the requirements on the formula are strict, in the actual blending process, the solubility of the pyrrolidone ethanolamine salt in water is extremely low, the hexidine di (hydroxyethyl sulfonate) salt is sensitive to the pH change of a medium, the stability of the functional components added into the composition is usually difficult to maintain for a long time, and in order to further improve the stability and the temperature resistance of the composition, as a preferable technical scheme, the surfactant at least comprises an anionic surfactant and a zwitterionic surfactant; preferably, the surfactant is selected from one or a combination of several of sodium lauroyl sarcosinate, sodium lauryl sulfate, coco betaine and cocamidopropyl betaine; preferably, the surfactant is a combination of sodium lauroyl sarcosinate, cocamidopropyl betaine; after a great deal of attempts, the invention unexpectedly discovers that sodium lauroyl sarcosinate and cocamidopropyl betaine are selected to act together in a system, a compact arrangement mode can be formed in an oil-water phase, the formed mixed micelle uniformly wraps active functional components and is dispersed in a mixed system formed by a solvent A and a solvent B, the electric repulsion of an adsorption layer and charged ions is weakened, the flocculation and precipitation tendency of the composition under the temperature change is obviously inhibited, and the stability is obviously improved. Further, the invention discovers that the weight ratio of the sodium lauroyl sarcosine to the cocamidopropyl betaine is (0.5-2): 1, the compatibility of the formula promotes the components such as the conditioner, the plant extract and the like to play the antibacterial, anti-inflammatory and anti-dandruff effects to the maximum extent, and the diameter of the bacteriostatic ring of the composition can reach 35.95-36.12mm.

The CAS number of the sodium lauroyl sarcosinate is 137-16-6, the product number is N812358, and the sodium lauroyl sarcosinate is purchased from Maxin Biotechnology Co., ltd, shanghai, north China; the cocamidopropyl betaine has a CAS number of 86438-79-1 and a product number of C875609, and is purchased from Maxim Biotechnology Co., ltd, north Shanghai.

As a preferable technical scheme, the functional auxiliary agent is at least one selected from glycol salicylate, hexyl salicylate, phenyl salicylate and ethylhexyl salicylate; preferably, the functional assistant is glycol salicylate, which is beneficial to the dissolution and dispersion of menthol and polylysine in a system, so that the overall stability of the composition is improved, and a certain sunscreen effect is achieved.

The glycol salicylate has CAS number 87-28-5 and product number E808711, and is purchased from Shanghai Maxin Biotechnology, inc.

As a preferred technical scheme, the solvent comprises a solvent A and a solvent B; preferably, the solvent A is deionized water, the solvent B is C2-C4 dihydric alcohol, and preferably, the solvent B is propylene glycol; preferably, the mass ratio of the solvent A to the solvent B is (0.8-1.2): 1.

the preparation method of the composition for relieving itching, removing dandruff and controlling oil at least comprises the following steps:

(1) Preparing the phase A: adding the solvent A into a container according to a certain proportion, heating to 50-80 ℃, adding the hexamidine di (isethionic acid) salt, stirring for 10-20min under the condition that the rotation speed is 200-500 rmp, cooling to 40-50 ℃, adding PCA zinc and amino acid compounds, and stirring for 25-35min under the same rotation speed to obtain phase A;

(2) B phase preparation: weighing pyrrolidone ethanolamine salt and a surfactant according to the mass percentage, placing the mixture into a container, controlling the temperature to be 70-90 ℃, and stirring for 10-15min under the condition that the rotating speed is 200-500 rmp to obtain a phase B;

(3) C, preparation of a phase C: weighing the solvent B, the 10-hydroxydecanoic acid and the plant extract according to the mass percentage, placing the mixture into a container, controlling the temperature to be 40-50 ℃, and stirring for 30-40min under the condition that the rotating speed is 200-500 rmp to obtain a phase C;

(4) And stirring the phase A, the phase B, the phase C, the functional assistant and the zinc oxide at 40-50 ℃ and 200-500 rmp for 30-40min to obtain the mixture.

The invention also provides application of the composition for relieving itching, removing dandruff and controlling oil, which is applied to hair washing and hair care products.

Has the advantages that:

1. the composition for relieving itching, removing dandruff and controlling oil provided by the invention has the advantages of high safety, good stability, mildness, comfort, moisture retention, excellent oil controlling, bacteriostasis and dandruff removing effects, and can be used alone or in combination with other hair washing and caring products.

2. The combination of the hexidine di (hydroxyethyl sulfonate), the pyrrolidone ethanol ammonium salt and the 10-hydroxydecanoic acid is adopted as a conditioning agent, and the weight ratio of the hexidine di (hydroxyethyl sulfonate), the pyrrolidone ethanol ammonium salt and the 10-hydroxydecanoic acid is controlled to be (0.1-2): (3-10): (2-15), the safety of the composition is improved, the stratum corneum of the skin is prevented from being damaged after a chemical reagent is used, the effects of relieving itching, controlling oil and removing dandruff are provided for the skin, the soothing and safety of the composition are improved, and the composition can act on the scalp and hairlines gently and efficiently.

3. Adopting PCA zinc and zinc oxide, and controlling the weight ratio of the PCA zinc to the zinc oxide to be (2-7): (0.1-1), especially when the adopted zinc oxide is nano zinc oxide with the diameter of 30 +/-10 nm, the antibacterial property and the moisture retention of the composition can reach higher levels, and the composition has no irritant cool feeling in the using process, so that the conditioning effect and the sensory experience feeling of the composition are both considered.

4. When the weight ratio of the conditioning agent, the zinc-series compound and the polylysine is (9-18): (2-8): (3-10), the obtained composition can stay on the surface layer of the skin for a proper time, the composition has certain washing resistance, and meanwhile, the composition has improved capability of damaging the membrane structure of microorganisms under the condition, so that the physiological activity of harmful microorganisms is further inhibited, and the regulation and control of the balance of scalp flora are promoted; the composition can be matched with a specific plant extract to improve the use experience of the composition, and the hair can be deeply moisturized and maintained from the hair to the hair root while dirt is cleaned.

5. The invention selects sodium lauroyl sarcosinate and cocamidopropyl betaine to act together in a system, and controls the weight ratio of the sodium lauroyl sarcosinate to the cocamidopropyl betaine to be (0.5-2): 1, a compact arrangement mode can be formed in an oil-water phase, the formed mixed micelle uniformly wraps active functional components, the dispersibility of the system is improved, the stability of the system is obviously improved, the compatibility of the formula furthest promotes the components such as a conditioner, a plant extract and the like to play the antibacterial, anti-inflammatory and anti-dandruff effects, and the diameter of a bacteriostatic ring of the composition can reach 35.95-36.12mm.

Detailed Description

Example 1

The embodiment 1 of the invention provides a composition for relieving itching, removing dandruff and controlling oil, which at least comprises the following preparation raw materials in percentage by weight: 14% of conditioner, 5.5% of zinc compound, 6% of amino acid compound, 3% of plant extract, 45% of surfactant, 3% of functional assistant and the balance of solvent.

The conditioner is a combination of a hexmidine di (hydroxyethyl sulfonate), a pyrrolidone ethanol ammonium salt and 10-hydroxydecanoic acid, wherein the weight ratio of the hexmidine di (hydroxyethyl sulfonate), the pyrrolidone ethanol ammonium salt to the 10-hydroxydecanoic acid is 0.5:6:7.5.

The plant extract is a mint extract; the mint extract is menthol, the CAS number of the menthol is 89-78-1, and the menthol is purchased from Jiangxi Baicao pharmaceutical industry Co.

The zinc-based compound is a combination of zinc PCA and zinc oxide; the weight ratio of the PCA zinc to the zinc oxide is 5:0.5.

The amino acid compound is polylysine, the CAS number of the polylysine is 28211-04-3, and the polylysine is purchased from Topson Biotech, inc. of Beijing.

The surfactant is a combination of sodium lauroyl sarcosinate and cocamidopropyl betaine; the weight ratio of sodium lauroyl sarcosinate to cocamidopropyl betaine is 1:1.

the CAS number of the sodium lauroyl sarcosine is 137-16-6, the product number is N812358, and the sodium lauroyl sarcosine is purchased from Meclin Biotechnology Co., ltd, shanghai, north China; the cocamidopropyl betaine has a CAS number of 86438-79-1 and a product number of C875609, and is purchased from Meclin Biotech, inc., of Shanghai, north China.

The functional assistant is glycol salicylate, the CAS number of the glycol salicylate is 87-28-5, the product number is E808711, and the functional assistant is purchased from Shanghai Michelin Biochemical technology Co.

The solvent comprises a solvent A and a solvent B; the solvent A is deionized water, and the solvent B is propylene glycol; the mass ratio of the solvent A to the solvent B is 1:1.

(1) Preparing the phase A: adding the solvent A into a container according to a certain proportion, heating to 60 ℃, adding the hexamidine di (hydroxyethyl sulfonate) salt, stirring for 15min under the condition that the rotation speed is 360rmp, cooling to 45 ℃, adding the PCA zinc and the amino acid compound, and stirring for 30min at the same rotation speed to obtain a phase A;

(2) B phase preparation: weighing pyrrolidone ethanolamine salt and a surfactant according to the mass percentage, placing the mixture into a container, controlling the temperature to be 70-90 ℃, and stirring for 12min under the condition that the rotating speed is 400rmp to obtain a phase B;

(3) C, preparation of phase C: weighing the solvent B, 10-hydroxydecanoic acid and the plant extract according to the mass percentage, placing the mixture into a container, controlling the temperature to be 45 ℃, and stirring for 35min under the condition that the rotating speed is 300rmp to obtain a phase C;

(4) And stirring the phase A, the phase B, the phase C, the functional assistant and the zinc oxide at 45 ℃ and 300rmp rotating speed for 35min to obtain the mixture.

Example 2

The embodiment 2 of the invention provides a composition for relieving itching, removing dandruff and controlling oil, which at least comprises the following preparation raw materials in percentage by weight: the zinc-based water-based oil-based detergent comprises 18% of a conditioner, 8% of a zinc compound, 9% of an amino acid compound, 5% of a plant extract, 50% of a surfactant, 5% of a functional assistant and the balance of a solvent.

The conditioner is a combination of a hexmidine di (hydroxyethyl sulfonate), a pyrrolidone ethanol ammonium salt and 10-hydroxydecanoic acid, wherein the weight ratio of the hexmidine di (hydroxyethyl sulfonate), the pyrrolidone ethanol ammonium salt and the 10-hydroxydecanoic acid is 1:9:10.

The zinc-based compound is a combination of zinc PCA and zinc oxide; the weight ratio of the zinc PCA to the zinc oxide is 7:1.

The surfactant is a combination of sodium lauroyl sarcosinate and cocamidopropyl betaine; the weight ratio of sodium lauroyl sarcosine to cocamidopropyl betaine is 1.2:1.

The solvent comprises a solvent A and a solvent B; the solvent A is deionized water, and the solvent B is propylene glycol; the mass ratio of the solvent A to the solvent B is 1.2:1.

(2) B, preparation of a phase: weighing pyrrolidone ethanolamine salt and a surfactant according to the mass percentage, placing the mixture into a container, controlling the temperature to be 70-90 ℃, and stirring for 12min under the condition that the rotating speed is 400rmp to obtain a phase B;

Example 3

The embodiment 3 of the invention provides a composition for relieving itching, removing dandruff and controlling oil, which at least comprises the following preparation raw materials in percentage by weight: 9.1% of conditioner, 2.1% of zinc compound, 4% of amino acid compound, 2% of plant extract, 40% of surfactant, 1% of functional assistant and the balance of solvent.

The conditioner is a combination of a hexmidine di (isethionic acid) salt, a pyrrolidone ethanol ammonium salt and 10-hydroxydecanoic acid, wherein the weight ratio of the hexmidine di (isethionic acid) salt, the pyrrolidone ethanol ammonium salt and the 10-hydroxydecanoic acid is 0.1:4:5.

the cimetidine bis (isethionate) salt has a CAS number of 659-40-5 and is purchased from shanghai-derived leafy biotechnology limited; the CAS number of the pyrrole ketamine ethanol ammonium salt is 68890-66-4, and the pyrrole ketamine ethanol ammonium salt is purchased from Hebeijin chemical engineering Co., ltd; the CAS number for 10-hydroxydecanoic acid is 68890-66-4, purchased from Bailingwei technologies, inc. of Beijing.

The zinc-based compound is a combination of zinc PCA and zinc oxide; the weight ratio of the zinc PCA to the zinc oxide is 2:0.1.

The amino acid compound is polylysine, the CAS number of the polylysine is 28211-04-3, and the polylysine is purchased from Topson Biotech limited, beijing.

The surfactant is a combination of sodium lauroyl sarcosinate and cocamidopropyl betaine; the weight ratio of sodium lauroyl sarcosine to cocamidopropyl betaine is 0.9:1.

the CAS number of the sodium lauroyl sarcosinate is 137-16-6, the product number is N812358, and the sodium lauroyl sarcosinate is purchased from Maxin Biotechnology Co., ltd, shanghai, north China; the cocamidopropyl betaine has a CAS number of 86438-79-1 and a product number of C875609, and is purchased from Meclin Biotech, inc., of Shanghai, north China.

The solvent comprises a solvent A and a solvent B; the solvent A is deionized water, and the solvent B is propylene glycol; the mass ratio of the solvent A to the solvent B is 0.9:1.

(3) C, preparation of a phase C: weighing the solvent B, 10-hydroxydecanoic acid and the plant extract according to the mass percentage, placing the mixture into a container, controlling the temperature to be 45 ℃, and stirring for 35min under the condition that the rotating speed is 300rmp to obtain a phase C;

Comparative example 1

Comparative example 1 of the present invention provides a composition for relieving itching, removing dandruff and controlling oil, which is prepared in the same manner as in example 1 except that the conditioner is pyrrolidone ethanolammonium salt.

Comparative example 2

Comparative example 2 of the present invention provides a composition for relieving itching, removing dandruff and controlling oil, which is the same as example 1 except that the content of the zinc-based compound is 0.

Comparative example 3

Comparative example 3 of the present invention provides a composition for relieving itching, removing dandruff and controlling oil, which is embodied in the same manner as in example 1 except that the content of the amino acid-based compound is 0.

Comparative example 4

Comparative example 4 of the present invention provides a composition for relieving itching, removing dandruff and controlling oil, which is embodied in the same manner as example 1 except that the surfactant is cocamidopropyl betaine.

Performance test method

1. Physical and chemical stability:

(1) High-temperature stability: referring to GB/T29679-2013, the compositions for relieving itching, removing dandruff and controlling oil prepared in examples and comparative examples are placed at 40 ℃ for 48 hours, and if no layering of the compositions is observed after room temperature is recovered, the high-temperature stability is marked as 'excellent'; if delamination of the composition is observed after returning to room temperature, the high temperature stability is reported as "poor".

(2) Low-temperature stability: the compositions for relieving itching, removing dandruff and controlling oil prepared in the examples and the comparative examples are placed at-8 ℃ for 48 hours, and if no layering of the compositions is observed after the room temperature is restored, the low-temperature stability is marked as 'excellent'; if delamination of the composition is observed after returning to room temperature, the low temperature stability is reported as "poor".

2. The efficacy is as follows: the diameters of the inhibition rings of the compositions for relieving itching, removing dandruff and controlling oil prepared in examples and comparative examples are determined according to the part of the microorganism inspection method in chapter five of the technical Specification for safety of cosmetics 2015 edition; the specific determination method comprises the following steps: (1) Uniformly coating the composition to be tested on the sterilized and dried sample piece by using sterile tweezers; (2) Preparing the activated malassezia into 100cfu/mL bacterial suspension, smearing 0.3mL bacterial suspension on a culture medium flat plate with the thickness of 12cm, naturally standing for 10min, and drying the culture medium flat plate in a sterile ultra-clean workbench by using sterile wind; (3) Attaching 3 test pieces on each culture medium flat plate, lightly pressing the test pieces with sterile forceps to make the test pieces tightly attached to the surface of the culture medium flat plate, placing the culture medium flat plate in a constant-temperature incubator at 32 ℃ for inverted culture for 7 days, and measuring the diameter of the bacteriostatic ring by using a vernier caliper.

3. Safety: the safety of the antipruritic, anti-dandruff and oil control compositions prepared in the examples and comparative examples was tested with reference to chapter 6.4 skin irritation/corrosiveness test section of the cosmetic safety specification 2015 edition.

Claims

1. The composition for relieving itching, removing dandruff and controlling oil is characterized by comprising the following preparation raw materials in percentage by weight: 0.1-23% of conditioner, 1-10% of zinc compound, 1-12% of amino acid compound, 0.5-8% of plant extract, 30-54% of surfactant, 0.8-6.0% of functional assistant and the balance of solvent.

2. The composition for relieving itching, removing dandruff and controlling oil according to claim 1, wherein the conditioning agent is selected from one or more of self-imidazole di (isethionate) salt, pyrrolidone ethanol ammonium salt, 10-hydroxydecanoic acid, chitosan quaternary ammonium salt and silicone quaternary ammonium salt.

3. The composition for relieving itching, removing dandruff and controlling oil according to claim 2, wherein the conditioning agent is a combination of hexmidine di (isethionic acid) salt, pyrrolidone ethanolamine salt and 10-hydroxydecanoic acid.

4. The composition for relieving itching, removing dandruff and controlling oil according to claim 1, wherein the plant extract is at least one selected from the group consisting of mint extract, linseed extract, black sesame extract and aloe extract.

5. The composition for relieving itching, removing dandruff and controlling oil according to any one of claims 1 to 4, wherein the zinc-based compound comprises zinc PCA, zinc oxide.

6. The composition for relieving itching, removing dandruff and controlling oil according to claim 1, wherein the weight ratio of the conditioner, the zinc compound and the amino acid compound is (9-18): (2-8): (3-10).

7. The composition for relieving itching, removing dandruff and controlling oil according to claim 1, wherein the surfactant comprises at least anionic surfactant and zwitterionic surfactant.

8. The composition for relieving itching, removing dandruff and controlling oil according to claim 1, wherein the solvent comprises a solvent A and a solvent B, and the mass ratio of the solvent A to the solvent B is (0.8-1.2): 1.

9. the composition for relieving itching, removing dandruff and controlling oil according to claim 8, wherein the solvent B is C2-C4 glycol.

10. Use of a composition for relieving itching, removing dandruff and controlling oil according to any one of claims 1 to 9 in hair washing and hair care products.