KR100448434B1 - Hair-care cosmetic compositions having dandruff formation-suppressing effect - Google Patents

Abstract

The present invention relates to a hair cosmetic composition having an anti-dandruff effect, wherein the hair cosmetic composition according to the present invention contains peppermint ( Mentha Piperita L. ) extract, or further contains zinc pyrithione or salicylic acid, which is a known antidandruff agent. It is to provide a hair cosmetic composition excellent in dandruff reduction, itching prevention and bactericidal effect.

Description

Hair-care cosmetic compositions having dandruff formation-suppressing effect}

The present invention relates to a hair cosmetic composition having an anti-dandruff effect, wherein the hair cosmetic composition according to the present invention contains peppermint ( Mentha Piperita L. ) extract, or further contains zinc pyrithione or salicylic acid, which is a known antidandruff agent. It is to provide a hair cosmetic composition excellent in dandruff reduction, itching prevention and bactericidal effect.

In general, dandruff refers to the stratum corneum-like mass formed by the dead or peeled cells of the scalp caused by the active metabolism of the human body with the secretion of the scalp sebaceous glands. Dandruff gradually has a clear border with normal skin, becomes red, and increases the scale of the scalp, which usually leads to seborrheic dermatitis with itching and inflammation.

The root cause of dandruff development is not yet clear, but in general, neurological factors such as endocrine hormone imbalance, metabolic imbalance, stress, biochemical changes in epithelial tissue due to excessive proliferation of scalp cells, and scalp It is known to be due to a complex effect of several factors such as the growth and activity of microorganisms, inflammation caused by air pollution.

In particular, Petey Los form Ovalle increased proliferation and activity of microorganisms that (Pityrosporum Ovlae), which did not exist in the clean scalp is widely accepted deulyeojigo recent example came long been recognized as a major factor ago, aggravate dandruff and itching.

Therefore, in the case of hair cosmetics having an anti-dandruff effect for the treatment and prevention of dandruff and itching, it effectively inhibits the proliferation and activity of the microbial phytirosporum obale, which is the main cause of dandruff, and abnormal metabolic activity of the scalp cells. It is an essential requirement to contain the component which can normalize the

Thus, as an example of the hair cosmetic composition aimed at suppressing dandruff and itching, the hair cosmetic composition containing zinc pyrithione (zinc-2-pyridinezol-1-oxide) as an active ingredient is mentioned ( US Patent No. 2,809,971, US Patent No. 4,323,683, US Patent No. 4,345,080, US Patent No. 4,470,982, and European Patent No. 285,388). In addition, pyrotonolamine (2 (1H) -pyridone, 1-hydroxy-4-methyl-6- (2,4,4-trimethylpentyl) and 2-soluble in water and exhibiting effective anti-dandruff efficacy Hair cosmetic compositions containing aminoethanol 1: 1) (C & T, Vol. 103, 49, February, 1988). However, zinc pyrithione is a water-insoluble solid particle having a spherical shape of about 1 μm having a very low limit of solubility of only 15 ppm in 25 ° of water. Induced by sedimentation in sedimentation, etc. are limited in its usability, and its content is regulated by the domestic agency and the US Food and Drug Administration (FDA) as a matter of irritation and safety to the human body.

Thus, the present inventors While reviewing the material with the antiseptic and antibacterial effect against major causes of Petey Los Ovalle form of stand-dandruff occurs without causing a problem of safety at a low stimulation of the human body, and peppermint (Mentha Piperita L.) extracts the repetition has the antimicrobial and antibacterial effect for the Los form O Valle the present invention was completed in view of that.

Accordingly, it is an object of the present invention to provide a hair cosmetic composition that can provide dandruff reduction, anti-itch and bactericidal effect.

In order to achieve the above object, the hair cosmetic composition according to the present invention is characterized in that it contains from 0.01 to 10% by weight peppermint extract ( Mentha Piperita L. ) based on the total weight of the composition.

In addition, in order to achieve the above object, the hair cosmetic composition according to the present invention is characterized by further containing 0.01 to 10% by weight of zinc pyrithione or salicylic acid, which is a known antidandruff agent, based on the total weight of the composition.

Other objects and applications of the present invention will become apparent from the following detailed description.

Hereinafter, the present invention will be described in more detail.

Peppermint extract used as an active ingredient exhibiting an anti-dandruff effect in the present invention is a perennial plant of Laminaceae, which is native to Europe and is cultivated in various parts of the world, such as Europe and the United States, has a fragrance to the plant itself, and the height is The stem has a quadrilateral cross section of 30 to 80 cm, and is upright and branched from the top. In the present invention, the leaves of the peppermint ( Mentha Piperita L. ) having the above characteristics is extracted by steam distillation at high temperature to use the peppermint extract.

This peppermint extract contains menthol, menthone, isomenthine, ??-pinene, kempen, limonene, tannin, and pectin. Menthol, the main ingredient of peppermint extract, has bactericidal and antibacterial activity against microorganisms such as pathogenic fungi, Escherichia coli, Staphylococcus aureus, which cause eczema, scabies, etc. present in skin or scalp. . In particular, it can inhibit the growth and activity of the microorganism called Pityrosporum Ovale , which is a major cause of worsening dandruff and itching, and can reduce irritation, erythema and seborrheic inflammation.

Peppermint extract used in the present invention can be prepared according to a conventional method, for example, it can be obtained by separating the solution obtained by extracting the leaves of Mentha Piperita L. by steam distillation.

Peppermint extract used as an anti-dandruff agent in the present invention is blended in an amount of 0.01 to 10% by weight, preferably in an amount of 0.1 to 6% by weight based on the total weight of the composition to constitute a hair cosmetic composition.

In addition, in the hair cosmetic composition of the present invention, zinc pyrithione or salicylic acid is contained in an amount of 0.01 to 10% by weight based on the total weight of the composition as another antidandruff bacterium.

The hair cosmetic composition of the present invention may have a conventional formulation, and may be formulated, for example, as a shampoo, rinse, hair conditioner, hair tonic, hair treatment, or the like. The composition of each of these formulations may contain a variety of bases and additives necessary for the formulation of the formulation and are suitable, and the types and amounts of these components can be readily selected by those skilled in the art.

Hereinafter, representative base components and additives will be described taking representative shampoo compositions of the hair cosmetic composition as an example.

For example, in the case of a shampoo formulation, in the present invention, a shampoo composition composed of synthetic surfactants, pearlescent aids, preservatives, thickeners and viscosity adjusting agents, pH adjusting agents, fragrances, dyes, hair conditioning agents, and water, which are washing ingredients, Synthetic surfactants used are 10 to 70% by weight of the composition, preferably 10 to 30% by weight of the composition, and more preferably 10 to 10, which may be any of anionic, amphoteric, nonionic and cationic surfactants. It may be contained in an amount of 20% by weight.

Synthetic anionic surfactants that can be used in the present invention are represented by the formula (1) as alkyl and alkylethersulfate.

RO (C ₂ H ₄ O) _n SO ₃ M

In said formula, R is a C10-C22 alkyl group, n is 0-4, M is chosen from water-soluble cations, such as ammonium, sodium, and triethanolamine. Preferably, alkyl sulfates and alkyl ether sulfates having 12 to 16 carbon atoms of R are preferable. Alcohols may be derived from or synthesized from fats such as palm oil or tallow. In the present invention, lauryl alcohol and linear alcohol derived from palm oil are preferable. This alcohol is reacted with 1 to 4 moles of ethylene oxide, in particular 3 moles, for example to sulfate and neutralize the resulting mixture of molecular species with an average of 3 moles of ethylene oxide per mole of alcohol. Specific examples thereof include sodium lauryl sulfate, lauryl ammonium sulfate, lauryl sulfate triethanolamine, polyoxyethylene lauryl sulfate, polyoxyethylene lauryl ammonium sulfate, and the like.

Synthetic amphoteric surfactants are alkyl betaines and alkyl amidopropyl betaines represented by formulas (2) and (3).

In the above formula, R ₁ is an alkyl group having 8 to 18 carbon atoms, and R ₂ CO is an alkoxy group having 8 to 18 carbon atoms. Specific examples include cocodimethyl carboxymethyl betaine, lauryldimethyl carboxymethyl betaine, lauryldimethyl ??-carboxyethyl betaine, cetyldimethyl carboxymethyl, cocoamido propylbetaine and the like.

Synthetic nonionic surfactants are represented by the formulas (4) and (5) as alkanolamides and alkylamine oxides.

R _One R ₂ R ₃ N ?? O

In said formula, R <_1> is a C8-C18 alkyl group, R <_2> and R <_3> is a C1-C3 alkyl group, R <_4> CO is a C8-C16 alkoxy group, n is 0 or 1. Specific examples include lauryldiethylamine oxide, palm oil alkyldimethylamine oxide, lauric acid diethanolamide, palm oil fatty acid diethanolamide, palm oil fatty acid monoethanolamide, and the like.

The above-mentioned surfactants can be selected and used alone or in combination in the hair cosmetic composition of the present invention.

Hair cosmetic composition according to the present invention can be used according to a conventional method of use, the number of times of use can be varied according to the user's scalp state or taste.

Hereinafter, the hair cosmetic composition of the present invention will be described in more detail with reference to examples of the present invention, but the present invention is not limited only to these examples.

<Examples 1-7 and Comparative Examples 1-2>

Raw material name Comparative example Example One 2 One 2 3 4 5 6 7   1. Sodium lauryl sulfate 2. Palm oil fatty acid diethanol amide 3. Propylene glycol 4. Methyl paraoxybenzoate 5. Polyquaternium-7 6. Pigment 7. Fragrance 8. Citric acid 9. Peppermint extract 10. Zinc pyrithion 11. Salicylic Acid 12. Purified Water 15.0 3.0 1.0 0.2 1.0 Proper quantity --- to 100 15.0 3.0 1.0 0.2 1.0 15.0 3.0 1.0 0.2 1.0 appropriate quantity 0.3--to 100 15.0 3.0 1.0 0.2 1.0 Proper quantity 0.5--to 100 15.0 3.0 1.0 0.2 1.0 Proper quantity 2.0 1.0-to 100 15.0 3.0 1.0 0.2 1.0 Proper quantity 2.0-0.5to 100 15.0 3.0 1.0 0.2 1.0 Proper quantity 4.0--to 100 15.0 3.0 1.0 0.2 1.0 15.0 3.0 1.0 0.2 1.0 appropriate quantity appropriate quantity 4.0 1.0 0.5 to 100

Test Example 1 Antibacterial Activity Comparison Test

The test bacteria were streaked on the agar plates containing the shampoos of the comparative examples and examples according to the concentrations, and the dandruff-causing bacteria were incubated for 2 days under aerobic conditions, followed by observing the growth of bacteria and the lowest inhibition of the growth of test bacteria. The concentration (MIC) was measured to confirm the antimicrobial activity against the causative agent of dandruff.

Test bacteria

Dandruff organisms: Petey Los form Ovalle ATCC 12087

2. Medium used

   Blood agar medium (quantity of blood agar base + final concentration 5%, blood), BHI agar

Minimum inhibitory concentration (MIC, ㎍ / ㎖) Comparative example Example One 2 One 2 3 4 5 6 7 Fitirosporum Ovalle > 0.5 > 0.35 0.200 0.040 0.012 0.015 0.020 0.006 0.002

As can be seen in Table 1, the hair cosmetic composition of Examples 1 to 7 containing the peppermint extract of the present invention can be seen to reduce the MIC against dandruff, and also increase the amount of MIC as the content of the peppermint extract increases. It can be seen that excellent. Thus, the composition of the present invention can be effectively used for the prevention of dandruff production, dandruff treatment and alleviation.

In addition, it can be seen that the reduction of MIC is further increased in Examples 3 to 4 and 6 to 7 using zinc pyrithione or salicylic acid, which are known antidandruff bacteria, together with the hair cosmetic composition of the present invention.

<Test Example 2> dandruff reduction effect test

54 men aged 19-35 years of age with relatively high dandruff were selected and tested for 1 month in 9 groups of 6 people for each comparative example and example, and the results are shown in Table 2.

Trituration with a normal shampoo before the start of the test, the weight of the dandruff collected by collecting the dandruff accumulated for three days after the three times, and the dandruff accumulated three days after the end of the test by three times every three days with the shampoo of each Example and Comparative Example The weight of was compared. At this time, the accumulated dandruff was collected directly from the scalp with a vacuum suction device, and the dandruff reduction rate was calculated based on the following equation.

Dandruff Reduction (%) =

{Weight of mg dandruff before test start-mg of dandruff 1 month after test start}

ㆇ {weight of dandruff before starting test (mg)}} 100

Comparison of effects of dandruff reduction rate (%) Comparative example Example One 2 One 2 3 4 5 6 7 Dandruff reduction rate (%) 3.7 16.6 22.7 27.0 40.3 34.4 31.1 50.3 61.9

As shown in Table 2, the average dandruff reduction rate in the Examples containing peppermint extract of the present invention was increased, and zinc pyrithione or salicylic acid, which is a known antidandruff agent, was used as in Examples 3 to 4 and 6 to 7. It can be seen that the dandruff suppression effect is further improved when it contains.

<Test Example 3> scalp anti-itch effect test

Forty nine men who felt relatively itching were selected, seven groups of seven people for each example and comparative example were tested for two months, and the results are shown in Table 3.

[Evaluation standard]

  Very itchy ..... 5 points

  Slightly itchy ..... 4 points

  Normal ..... 3 points

  OK ..... 2 points

  Not itchy ..... 1 point

Scalp itching effect Comparative example Example One 2 One 2 3 4 5 6 7 Scalp itching effect 1.4 2.6 2.8 3.1 3.8 3.5 3.7 4.1 4.6

As shown in Table 3, it can be seen that the effect of removing the scalp itch in the Example containing the peppermint extract of the present invention. Moreover, as the content of the peppermint extract increases, it can be seen that the effect of removing the scalp itch when used together with zinc pyrithione or salicylic acid.

, The error correcting capability of Ross bideumgyun form O proliferation and peppermint (Mentha Piperita L.) with menthol (menthol) with the ability to inhibit activity of large amount, as an active ingredient of the extract is reduced dandruff ballet As can be seen from the above description And it shows a great effect on the suppression of itching, and when used together with the known anti-dandruff zinc pyrithione or salicylic acid shows a much superior dandruff and itching suppression effect by synergistic interaction.

Claims (1)

       In the hair cosmetic composition, an anti-dandruff hair cosmetic composition, which is contained in an amount of 0.01 to 10% by weight of peppermint extract, 0.01 to 10% by weight of zinc pyrithione, and 0.01 to 10% by weight of salicylic acid, based on the total weight of the composition.