KR20080109440A - Hair cosmetic compositions for anti-dandruff - Google Patents

Abstract

A hair cosmetic composition comprising the olive leaf extracts is provided to prevent dandruff by improving the antifungal efficacy and sebum oxidation-inhibiting effect. The hair cosmetic composition for the dandruff prevention contains 0.001-10.0 wt.% of the olive leaf extracts based on the total weight of the composition and the normal anti-dandruff element which is one or more element selected from the group consisting of piroctone olamine, zinc pyrithione, climbazole, selenium sulfide, ketoconazole and Iodopropynylbutyl carbamate.

Description

Hair Cosmetic Composition for Anti-Dandruff {Hair Cosmetic Compositions for Anti-Dandruff}

The present invention relates to a hair cosmetic composition for preventing dandruff. More specifically, the anti-dandruff hair cosmetic composition which can remove the itching of the scalp by inhibiting sebum oxidation by the anti-dandruff and antioxidant effect by adding olive leaf extract having excellent antifungal efficacy and sebum oxidation inhibitory effect to the conventional anti-dandruff component. It is about.

Dandruff is a natural release of dead cells from the scalp, usually the same as on the skin. Therefore, normal dandruff is invisible and small. However, in general, dandruff means that the keratinocytes of the scalp are lumped together by sebum, sweat, etc. secreted from the scalp. This dandruff is caused by rancidated fatty acids produced by the decomposition of sebum components, stimulating scalp basal layer cells, causing cell proliferation and accompanied by itching.

Anti-dandruff agents, which are antifungal agents that have excellent bactericidal power against Pyrosporum ovale, known as the causative agent of dandruff as a scalp fungus, have a problem in human safety, and their usage is legally limited, so the anti-dandruff effect is not maximized. There is a problem.

In addition, zinc pyrithione is a water-insoluble, high specific gravity particle having a spherical shape of about 1 μm having a very low limit of solubility of only 15 ppm in water at 25 ° C., which makes it difficult to uniformly disperse it in the hair cosmetic composition. (Gene A. Hyde and Mark M. Auerbach, Formulation Techniques for Zinc Pyrithione Antidandruff Shampoos.Cosmetics and Toiletries, 94, 57, April 1979.) The effects of a shampoo containing Zinc pyrithione on the control of dandruff.Br J Dermatol 112. 415. 1985). In particular, the skin causes contact dermatitis (Nielsen, N.H., Allergic contact dermatitis caused by zinc pyrithione associated with pustular psoriasis. Am J Contact Dermat. 8, 170, 1997), and is reported to cause problems such as environmental toxicity. Therefore, it is difficult to apply it to hair cosmetics at high concentration. Therefore, its use is limited and its content is regulated by the US Food and Drug Administration (FDA) as a matter of irritation and safety to the human body.

In addition, pyrotonolamine (2 (1H) -pyridone, 1-hydroxy-4-methyl-6- (2, Hair cosmetic compositions comprising 4,4-trimethylpentyl) and 2-aminoethanol 1: 1) are known (CT, Vol. 103, 49, February, 1988). However, this ingredient, too, must be added to the hair cosmetics in order to have a sufficient effect, and its use is regulated due to safety issues to the human body (see Cosmetics and Toiletries, 102, 6, Dec., 1987).

In addition, since it is an anti-dandruff agent, it is also used as an anti-dandruff agent because it shows an antimicrobial effect on the microorganisms, such as climbazole, selenium sulfide and ketoconazole, which are present in the scalp.

However, there has been a report that dandruff is not completely reduced despite the reduction of the scalp microorganisms by treating the scalp with antibacterial agents. Accordingly, the present inventors have paid attention to the characteristics of phyticosporum obale, a lipophilic fungus, in order to improve such effectiveness and safety.

And dandruff usually involves itching of the scalp. This itch is thought to cause itching due to scalp stimulation of free fatty acids produced by rancid sebum secreted from the scalp and detachment of non-keratized dandruff cells.

Olive Trees ( Olea europaea L. ) has been widely used as a source of natural healing agents for many years, including olive oil from olive fruit. In particular, Olive Leaf Tea has shown excellent effectiveness in reducing heat, parasites and gastrointestinal disorders over the last few centuries.

According to the results of various clinical experiments that have been extensively studied, olive leaf extract is known to have a strong antibiotic effect on various microorganisms such as viruses, bacteria, fungi and parasites. It is more powerful than any other type of natural antibiotic ever found, and it kills over 100 species of microorganisms that cause various diseases in our bodies.

The antimicrobial properties of olive leaves have been widely known in the Mediterranean, including ancient Egypt, for over 6,000 years. In Egypt, the extract was used to make royal mummies. The most important medical ingredient in olive leaf extract is oleuropein, which contains the phenolic compound Elenolic Acid. It is distributed in the bark, leaves, roots, berries, etc. of the olive tree, and serves to prevent the olive tree from the attack of various microorganisms, the most present in the olive leaf.

In order to solve the above problems, the present inventors have conducted a number of studies and experiments, using a small amount of the conventional anti-dandruff ingredient by adding olive leaf extract excellent in antifungal efficacy and sebum oxidation inhibitory effect to the conventional anti-dandruff component In addition, by inhibiting the increase in phytirosporm obale known as the causative agent of dandruff, it was found that it is possible to prepare a hair cosmetic composition excellent in the dandruff occurrence and scalp itching effect, and completed the present invention.

In order to achieve the above object, the present invention provides a hair cosmetic composition comprising a 0.001 to 10.0% by weight based on the total amount of the composition in the hair cosmetic composition comprising a conventional anti-dandruff component. .

The known anti-dandruff component is one selected from the group consisting of pyroctone olamine, zinc pyrithione, climbazole, selenium sulfide, ketoconazole and iodopropynylbutyl carbamate. It may be abnormal.

The product form of the hair cosmetic composition may be a shampoo, hair conditioner, hair tonic or hair cream.

Hereinafter, the present invention will be described in detail.

In the hair cosmetics according to the present invention, an olive leaf extract and a conventional anti-dandruff ingredient are used together for the purpose of removing scalp itch due to the anti-danger effect by the antifungal effect and the inhibition of sebum oxidation by the antioxidant effect.

The present inventors focus on the anti-fungal effect and antioxidant effect of the olive leaf extract to inhibit the sebum oxidation inhibiting the growth of physiological dandruff causing physiological dandruff in scalp, oxidized to free fatty acids or lipid peroxide and oxidized scalp It has been found that by inhibiting the oxidation of sebum, which stimulates hyperkeratosis by causing dandruff to prevent dandruff and scalp itching.

The amount of the olive leaf extract is preferably 0.001 to 10.0% by weight based on the total amount of the cosmetic composition. If the amount is less than 0.001% by weight, the effect of removing dandruff and itching of the scalp is insignificant, and when it exceeds 10.0% by weight, there is no significant effect increase.

Examples of the conventional anti-dandruff components include pyroctone olamine (Octopirox (Hoechst)), zinc pyrithione (Zinc Omadine (Arch)), klimbazole, selenium sulfide, ketoconazole and urethropropy. It is one or more selected from the group consisting of Iodopropynylbutyl Carbamate (trade name: Biodocarb C 450 or Biodocarb L 450 (M & G), Omacide IPBC (Arch)), and the like. The content is not limited, but the conventional anti-dandruff component is preferably 0.01 to 5.0% by weight based on the total amount of the composition. If the amount is less than 0.01% by weight of the anti-dandruff and itching effect of the scalp is insignificant, if the amount exceeds 5.0% by weight there is no further significant effect rise.

Hair cosmetic compositions of the present invention may have a conventional formulation, for example, is formulated with a shampoo, hair conditioner, hair tonic, hair cream and the like. The composition of each of these formulations may contain a variety of bases and additives necessary for the formulation of the formulation and are suitable, and the type and amount of these components can be readily selected by those skilled in the art. Hair cosmetic composition of the present invention may further comprise one or more selected from surfactants, fragrances, pigments, humectants, citric acid, preservatives.

Hereinafter, a shampoo, a hair conditioner, a hair tonic and a hair cream containing a manufacturing method and additives which can be prepared by those skilled in the art are as follows.

<Shampoo manufacturing>

Shampoo is a mixture of anionic surfactant, moisturizer, hair protection ingredients, water, etc. If you have a shampoo formulation, 30% sodium lauryl sulfate, 30% polyoxyethylene lauryl sulfate, palm oil fatty acid diethanolamide, ethylene glycol disulfide After adding tearate and propylene glycol to water, pyrotonolamine and iodopropynylbutyl carbamate are added to the mixture, which is then dissolved by heating and cooled. Zinc pyrithione, olive leaf extract, pigment, paraoxybenzoate, fragrance and citric acid are added to the mixture, mixed, and cooled to prepare a shampoo.

<Hair Conditioner Manufacturing>

In the case of a hair conditioner formulation, cetanol, self-emulsifying monostearate glycerin, paraoxybenzoic acid ester, 75% distearyl dimethylammonium chloride, pyroxtonolamine are added to water, and then dissolved by heating and cooled. Zinc pyrithione, olive leaf extract, pigment, fragrance and citric acid are added to this mixture and mixed, and a hair conditioner is prepared.

<Hair Tonic Manufacturing>

In the case of a hair tonic formulation, oil-free hair tonic dissolves fungicides, stimulants, etc. in 30-70% alcohol solution, and adds fragrance, and oily hair tonic adds oils, etc., in which disinfectants, stimulants, and fragrances are dissolved in pure alcohol. do. To the mixture is added to at least one selected from the group consisting of pyrotonolamine, zinc pyrithione and urethopynylbutyl carbamate known anti-dandruff and olive leaf extract to prepare a hair tonic.

<Hair Cream Maker>

If you have a hair cream formulation, beeswax, liquid paraffin, stearic acid, lanolin, fragrances, preservatives and some other ingredients are added to the mixtures, and then the known anti-dandruff ingredients pyroctonolamine, zinc pyrithione and urethra. Hairpin is prepared by adding one or more olive leaf extracts selected from the group consisting of propynylbutyl carbamate.

In particular, hair cosmetic compositions such as shampoo, hair conditioner, hair tonic and hair cream may be composed of a conventional composition except for the olive leaf extract.

Hereinafter, the present invention will be described in more detail with reference to the following examples, but the scope of the present invention is not limited to the examples.

[Examples 1 to 5 and Comparative Examples 1 to 5]

After adding 30% sodium lauryl sulfate, 30% polyoxyethylene lauryl sulfate, palm oil fatty acid diethanolamide, ethylene glycol distearate and propylene glycol in the composition ratio as shown in Table 1 below, the present invention was added to this mixture. Pyrotonolamine according to the addition, urido propynylbutyl carbamate was added until the temperature is 70 ℃ to dissolve uniformly and then cooled to 40 ℃. Zinc pyrithione, olive leaf extract, pigment, paraoxybenzoic acid ester, fragrance and citric acid were added to the mixture, mixed and cooled to prepare a shampoo.

Anti-dandruff and scalp itching effect of the shampoo was carried out in the same manner as in Experimental Example 1 and Example 2.

Experimental Example 1

50 relatively large dandruff were selected and tested for 1 month on the shampoo composition as shown in Table 1. Before starting the test, the hair was collected with a conventional shampoo and accumulated dandruff for 3 days, and the weight of the collected dandruff was triturated with the shampoo composition of Table 1, and the weight of the dandruff accumulated for 3 days after the end of the test was evaluated. At this time, the accumulated dandruff was collected directly from the scalp using a vacuum suction device, and the dandruff reduction rate was calculated by the following equation.

In addition, it was determined that the dandruff prevention effect is actually effective only when the dandruff reduction rate is 30% or more. The results are shown in Table 2.

Experimental Example 2

The secretion of sebum in Sebu tape where the first healthy men and women of 50 the top of the head right and left 2 to evaluate the sebum secretion inhibitory effect was determined by image analysis, and calculating the test before Sebum Excretion Rate (. SER, ug / cm 2 / min) . After applying the shampoo prepared in Table 1 to them for 30 seconds and then rinsing them for 1 month, Sebum Excretion Rate (SER) was sebum secreted with Sebu tape in the same area in the previous experiment. , ug / cm ² / min.) was calculated.

The percentage of sebum oxidation according to sebum secretion and sample application at steady state was judged as a sebum secretion inhibitory effect, and the results are shown in Table 3.

Experimental Example 3

Fifty men and women randomly selected from among those who felt itching were allowed to use the shampoo as shown in Table 1 once every two days for eight weeks, and then interviewed to check for relief of itching. Evaluation is based on the following criteria subjective subjective rating, and then averaged it is shown in Table 4.

* Evaluation criteria: Very good-Rating 5

             Good-Rating 4

             Normal-Rated 3

             None-rating 2

             No at all-rating 1

As can be seen in Tables 2 to 4 above, the shampoos of Examples 1 to 5 containing the olive leaf extract and the conventional anti-dandruff ingredient according to the present invention are the shampoos of Comparative Examples 1 to 5 according to the conventional methods. Compared to the anti-dandruff, sebum antioxidant effect and itching removal effect was found to be excellent.

[Examples 6 to 10 and Comparative Examples 6 to 10]

After adding cetanol, self-emulsifying monostearic acid ester, paraoxybenzoic acid ester, 75% distearyl dimethylammonium chloride, pyrotonolamine, and iodopropynylbutyl carbamate in the composition ratio as shown in Table 4 below, The mixture was warmed to a temperature of 65 ° C., dissolved uniformly, and cooled to 40 ° C. Subsequently, zinc pyrithione, olive leaf extract, pigment, flavor and citric acid were added to the mixture and mixed, to prepare a hair conditioner.

The anti-dandruff effect of the hair conditioner was carried out in the same manner as in Experimental Example 3.

Experimental Example 4

50 relatively high dandruff were selected and tested for 1 month on the hair conditioner prepared as shown in Table 4. Before starting the test, wash with a conventional shampoo and use a conventional hair conditioner, collect the dandruff accumulated for 3 days, triturate with the weight of the collected dandruff and the usual shampoo, and use the hair conditioner composition of Table 4 The weight of dandruff accumulated daily was compared and the results are shown in Table 5.

As can be seen in Table 5 above, the hair conditioner of Examples 6 to 10 containing the olive leaf extract and the conventional anti-dandruff component according to the present invention is the hair conditioner of Comparative Examples 6 to 10 according to a conventional method. Compared to the anti-dandruff effect was found to be excellent.

As described above, the anti-dandruff hair cosmetic composition according to the present invention is a useful invention having the effect of removing dandruff and scalp itch by adding olive leaf extract excellent in antifungal efficacy and sebum oxidation inhibitory effect to the conventional anti-dandruff ingredient. will be.

While the invention has been described in detail above with reference to the described embodiments, it will be apparent to those skilled in the art that various modifications and variations are possible within the scope and spirit of the invention, and such modifications and variations fall within the scope of the appended claims. It is also natural.

Claims (4)

In the anti-dandruff hair cosmetic composition containing a conventional anti-dandruff component, the hair cosmetic composition characterized in that it contains 0.001 to 10.0% by weight of the olive leaf extract based on the total amount of the composition. The anti-dandruff component is selected from the group consisting of Piroctone Olamine, Zinc Pyrithione, Climbazole, Selenium Sulfide, Ketoconazole and Iodopropynylbutyl Carbamate. Hair cosmetic composition, characterized in that at least one. According to claim 1, Hair cosmetic composition, characterized in that 0.01 to 5.0% by weight based on the total amount of the anti-dandruff composition. The hair cosmetic composition according to claim 1, which is a shampoo, hair conditioner, hair tonic or hair cream.