KR0141416B1 - Hair cosmetic compositions - Google Patents

Abstract

The present invention relates to a hair cosmetic composition for treating and preventing dandruff and itching of the scalp by using diiodomethyl-p-tolylsulphone alone or in combination with pyrotonolamine and allatoin. .

Description

Cosmetic composition for hair

The present invention relates to a cosmetic composition for hair excellent in the dandruff of the scalp, prevention of itching and its therapeutic effect, more specifically diiomethyl-p-tolysulphone (diodomethyl-p-tolysulphone) alone or It relates to a cosmetic composition for hair to treat and prevent dandruff, itching of the scalp by using p-tolylsulfone mixed with pyrotonolamine, allantoin.

In general, dandruff refers to the dead cells of the scalp that come off as a hard keratin form, and clump together with sebum, sweat, etc. secreted from the scalp. Normal dandruff occurs when rancidated fatty acids, which are produced by decomposition of cortical lipid components, stimulate cells in the scalp basal layer to induce cell hyperproliferation and are accompanied by itching. In particular, Pytirosporum Ovale, known as a cause of dandruff, is known to promote rancidity of sebum lipid components.

Diiomethylmethyl-p-tolylsulfone removes microorganisms such as bacteria, fungus and algae from cooling water, paper industry, pulp, ponds, lakes, latex, wood, plastics, leather, fats, oils, cosmetics and foods. And it has been widely applied to suppress the occurrence, and is known to be very low toxicity to humans (acute oral toxicity: LD50 = 10,000mg / ml (mouse), LD50 = 9,400mg / ml (rabbit)).

However, there have been no examples of using diiodomethyl-p-tolylsulfone in hair cosmetic compositions.

Therefore, the present inventors used diiodomethyl-p-tolylsulfone in the hair cosmetic composition to evaluate the bactericidal effect on the phytirosporum obale and the effect on the treatment and prevention of dandruff and itching. Has also been found to be superior, and the selective use of pyrotonolamine used in hair cosmetic compositions or allantoin, which is effective for wound repair or removal of eutrophic cells, can double the treatment and prevention of dandruff and itching. This invention was completed.

The amount of diiodomethyl-p-tolylsulfone for the purpose of the treatment and prevention of dandruff and itching in the hair cosmetic composition according to the present invention is preferably 0.01 to 5.0% by weight, more preferably 0.1 to 1.0% by weight Do. At this time, diiodomethyl-p-tolylsulfone may be used alone or in combination with pyrotonolamine, allantoin.

If the amount of diiodomethyl-p-tolylsulfone is less than 0.01% by weight, the effect is slight, and at 5.0% by weight or more, there is no significant increase in effect.

When using diiodomethyl-p-tolylsulfone mixed with pyrotonolamine in a ratio of 5: 2 to 5: 5, when using diiodomethyl-p-tolylsulfone mixed with allantoin 5 When diiodomethyl-p-tolylsulfone is mixed with both pyrotonolamine and allantoin, the ratio is 2: 2: 5 to 5: 5: 5. It is preferable.

The compositions according to the invention are used in conventional forms such as shampoos, hair conditioners, hair tonics and the like.

Hereinafter, the present invention will be described in more detail with reference to the following examples, which do not limit the technical scope of the present invention.

Examples 1 to 6 and Comparative Examples 1 to 3

The composition ratio 30% sodium lauryl sulfate, 30% polyoxyethylene sodium lauryl sulfate, palm oil fatty acid diethanolamide, propylene glycol as shown in Table 1 was added to water, and then to this mixture, diiomethyl-p-tolyl according to the present invention. Sulfon, pyroxtonolamine, and allantoin were added to warm up until the temperature reached 60 ° C, dissolved uniformly, and then cooled to 40 ° C. Then, a dye (blue No. 1), methyl paraoxybenzoate, fragrance (combination fragrance SKP-3473) and citric acid were added to the mixture, mixed, and cooled to prepare a shampoo.

Table 1

The anti-dandruff effect and the itch removal effect of this shampoo was carried out in the same manner as in Test Example 1, Test Example 2 and Test Example 3 and the results are shown in Tables 2 to 4.

Test Example 1

Forty-five men with high dandruff were selected and tested for 1 month on the shampoos in Table 1.

Before the start of the test, the hair was collected with a conventional shampoo, and the accumulated dandruff was collected for 3 days. . At this time, the accumulated dandruff was collected directly from the scalp using a vacuum suction device, and the dandruff reduction rate was calculated by the following equation.

In addition, the anti-dandruff effect was determined to be effective only when the dandruff reduction rate is 30% or more. The results are shown in Table 2.

TABLE 2

Test Example 2

Each shampoo of Table 1 was added to Ym broth containing 5%, 1%, 0.5%, and 0.1% of YM broth containing corn oil, and incubated for 2 days by inoculation with Pytyrosporum obale. The minimum microbial inhibition concentration (MIC) and the minimum microbial kill concentration (MCC) were measured. The results are shown in Table 3.

TABLE 3

Test Example 3

Forty-five men and women randomly selected from the itch who used the shampoo shown in Table 1 were used once every two days for eight weeks, and then interviewed and evaluated for reduction of itching. Evaluation was based on the following evaluation criteria subjects were subjectively rated, and then averaged and shown in Table 4.

Evaluation standard

Table 4

As shown in Table 2, Table 3, Table 4, the shampoos of Examples 1 to 3 containing diiodomethyl-p-tolylsulfone according to the present invention have a bactericidal power and anti-dandruff effect as compared to the shampoo of Comparative Example 1 The shampoos of Examples 4 to 6, which selectively used diiodomethyl-p-tolylsulfone, pyrotonolamine, and allantoin, were significantly better than the shampoos of Comparative Examples 2 to 3. It has been shown to be effective.

Examples 7-10 and Comparative Examples 4-6

Ethanol, self-emulsifying glycerin monostearate, methyl paraoxybenzoate, 25% stearyl dimethylbenzyl ammonium chloride, propylene glycol and diiodomethyl-p-tolylsulfone and pyroxtoneolamine according to the present invention in the composition ratio as shown in Table 5 Alternatively, allantoin was added to water, then the mixture was warmed to a temperature of 75 ° C., dissolved uniformly, and cooled to 40 ° C. Subsequently, a dye (blue No. 1), a fragrance (combination type SKP-3473) and citric acid were added to the mixture at a composition ratio as shown in Table 5, mixed, and cooled to prepare a hair conditioner.

Table 5

The anti-dandruff effect test for this was carried out in the same manner as in Test Example 4, Test Example 5, the results are shown in Table 6 and Table 7.

Test Example 4

Thirty-five males with relatively high dandruff were selected as subjects, and each hair conditioner in Table 5 was tested for one month. Before starting the test, wash with a conventional shampoo, use a conventional hair conditioner product, collect the dandruff accumulated for 3 days, and weigh the amount of dandruff weighed with a regular shampoo once every 2 days, and then use the hair conditioner shown in Table 5. The weight of the dandruff accumulated for 3 days after the end of the test was used and the results are shown in Table 6.

Table 6

At this time, it was determined that the dandruff reduction rate is only 30% or more when the dandruff reduction effect is less than 30%, it was determined that there is no dandruff prevention effect. Collection of dandruff and the rate of dandruff reduction were carried out in the same manner as in Test Example 1.

Test Example 5

5%, 1%, 0.5%, 0.1% of the hair conditioner of Table 5 was added to YM liquid medium containing corn oil, and then inoculated with Pytirosporum obale and cultured for 2 days, and then the minimum biocide concentration ( MIC) and MIC were measured. The results are shown in Table 7.

TABLE 7

As shown in Table 6 and Table 7, the hair conditioner of Example 7 containing diiodomethyl-p-tolylsulfone according to the present invention exhibits excellent sterilizing power and anti-dandruff effect compared to the hair conditioner of Comparative Example 4. The hair conditioner of Examples 8 to 10, which selectively mixed with diiodomethyl-p-tolylsulfone, pyrotonolamine, and allantoin, had superior sterilization and anti-dandruff effects than the hair conditioners of Comparative Examples 5 to 6. Appeared to be.

Examples 11-14 and Comparative Examples 7-9

L-menthol, D-panthenol, propylene glycol, pigments, flavorings and polyoxyethylene-cured castor oil and water in ethanol at the composition ratios shown in Table 8 and diiodomethyl-p-tolylsulfone, pyroxtoneolamine according to the present invention , Allantoin was added and mixed to prepare a hair tonic.

Table 8

Anti-dandruff effect was performed according to the following Test Example 6 and Test Example 7, the results are shown in Table 9 and Table 10, respectively.

Test Example 6

Thirty-five males with relatively high dandruff were selected as subjects, and each hair tonic in Table 8 was tested for two weeks.

Before the start of the test, use a conventional shampoo and collect the dandruff accumulated for 3 days, and weigh the amount of dandruff, and use the hair tonic of Table 8 once a day, using the regular shampoo once every 2 days, and after the end of the test. The weight of the dandruff accumulated over three days was compared and the results are shown in Table 9. Collection of dandruff and the rate of dandruff reduction were carried out in the same manner as in Test Example 1.

Table 9

Test Example 7

5%, 1%, 0.5%, and 0.1% of the hair tonic of Table 8 was added to YM liquid medium containing corn oil, and then inoculated with Pytilosporum obale and cultured for 2 days. ), Minimum microbial inhibitory concentration (MIC) and minimum microbial killing concentration (MCC) were measured. The results are shown in Table 10.

Table 10

As shown in Table 9 and Table 10, the hair tonic of Example 11 containing diiodomethyl-p-tolylsulfone according to the present invention exhibits excellent sterilizing and anti-dandruff effects compared to the hair tonic of Comparative Example 7. The hair tonic of Examples 12 to 14, which selectively mixed with diiodomethyl-p-tolylsulfone, pyrotonolamine, and allantoin, had superior sterilization and anti-dandruff effects than the hair tonic of Comparative Examples 7 to 9. Appeared to be.

On the other hand, Examples 11 to 14 of the hair tonic of the diiodomethyl-p-tolylsulfone according to the present invention alone or mixed with diiodomethyl-p-tolylsulfone, pyrotonolamine and allantoin It was shown that the anti-dandruff effect is more pronounced than the shampoo or hair conditioner according to the present invention, which is rinsed after use in the case of shampoo or hair conditioner, whereas in the case of hair tonic, the active ingredient is not rinsed after use so that the anti-dandruff effect is high. Appeared.

Claims (12)

A cosmetic composition for hair, comprising diiodomethyl-p-tolylsulfone. 2. A composition according to claim 1, which contains 0.01 to 5.0% by weight of diiodomethyl-p-tolylsulfone. A composition according to claim 2, which contains from 0.1 to 1.0% by weight of diiodomethyl-p-tolylsulfone. The composition of claim 1, further comprising pyrotonolamine. The composition according to claim 4, wherein the mixing ratio of diiodomethyl-p-tolylsulfone and pyrotonolamine is 5: 2 to 5: 5. The composition of claim 1 further comprising allantoin. The composition of claim 6, wherein the mixing ratio of diiodomethyl-p-tolylsulfone and allantoin is from 5: 2 to 5: 5. The composition of claim 1, further comprising pyrotonolamine and allantoin together. The composition according to claim 8, wherein the mixing ratio of diiodomethyl-p-tolylsulfone, pyroxtonolamine, allantoin is 5: 2: 2 to 5: 5: 5. The cosmetic composition for hair according to any one of claims 1 to 9 in the form of a shampoo. The cosmetic composition for hair according to any one of claims 1 to 9 in the form of a hair conditioner. The cosmetic composition for hair according to any one of claims 1 to 9 in the form of a hair tonic.