JPH03176413A - Cosmetic for skin, scalp and hair containing agent for inhibiting proliferation of dandruff bacteria and composed of component extracted from plant - Google Patents

Abstract

PURPOSE:To provide the objective cosmetic for skin, scalp and hair, effective in preventing dandruff and itchiness and containing agent for inhibiting proliferation of dandruff bacteria and composed of component extracted from Japanese and Chinese crude herb drugs. CONSTITUTION:The objective cosmetic can be prepared by compounding a hair-treating agent, a scalp-treating agent, a skin agent for external use or a cosmetic with 0.1-0.5wt.% of an agent for inhibiting proliferation of dandruff bacteria and containing a component extracted from at least one of the crude herb drugs such as SHOUIKYO (fruit of Foeniculum vulgare), OUREN (rhizome of Coptis japonica), SHOUKYOU (rhizome of Zingiber officinale), CHINPI (peel of Citrus unshu), TAISAN (bulb of Allium savitum), HAKKA (whole grass of Mentha arvensis), SHISO (leaf of Perilla frutenscens), TOUHI (fruit of Citrus aurantium) and nutmeg. The component extracted from crude herb drug is selected from an essential oil obtained by steam distillation, a solution produced by extracting the distillation residue of the essential oil with ethanol, a solution produced by diluting the essential oil component with ethanol, a solution produced by extracting the above crude herb drug with ethanol or a mixture of two or more kinds of the above solutions.

Description

Detailed Description of the Invention (A) Purpose of the Invention The present invention contains a dandruff bacteria growth inhibitor consisting of a plant-derived extract component. Concerning new applications.

The dandruff bacteria in the present invention are known to always reside on the scalp. Pityrosporum opal (hereinafter abbreviated as PO for convenience) belongs to the yeast fungus, and the active ingredient that has a growth inhibiting effect on this PO is found in the extracted components contained in the plant. The aim is to find new applications by incorporating it into external preparations for the skin, hair, and scalp (paints and rubs), and cosmetics.

"Industrial Application Field" According to the present invention. The po growth inhibitor, which is made from an extract of the specified plant, can be formulated into a dosage form (currently being prescribed) for external application or rubbing, and can be used as a pharmaceutical or quasi-drug.

Can be used as cosmetics.

Its effects can prevent, prevent, and improve the onset of dandruff caused by PO and the accompanying itching. Furthermore, the PO growth inhibitor obtained according to the present invention has a strong antioxidant effect on oils and fats, for example.

It is effective in preventing rancidity of the oil and fat base used in the formulation.

``Conventional technology'' Various causes have been known to cause dandruff and itching on the skin and scalp, but one of them is closely related to PO, which is resident on the scalp. It is said that the prevalence is particularly high from adolescence to adulthood, and symptoms associated with dandruff and itching are known to increase in such cases. Therefore, recently, drugs that inhibit or suppress the growth of PO are considered to be an effective way to prevent or prevent dandruff. There is a need for something that works.

In other words, research on the sebum secretion ability from a biochemical perspective has shown that dandruff or the itching that accompanies dandruff is caused by triglycerides in sebum entering the hair follicle canal.
Due to the intrusion of O, lipase production is increased,
This increases the production of glycerol and free fatty acids, and the excess free fatty acids produced at this time have a particularly strong effect on surface saturation and inflammation. Since it is addictive and lipophilic, as the amount of sebum increases and is stored in the follicular canal, PO is said to gradually increase as well.

In addition, neutrophil chemotactic ability and complement activation factors caused by PO, as well as the production of the bacteria 1, protease, lipase, hyaluronidase, etc., cause destruction of the hair follicle epithelium and induction of inflammation. is also being considered as a new hypothesis.

In addition to the above factors, the disease develops due to a complex interrelationship of internal and external factors such as genetic factors, age, dietary factors, gastrointestinal disorders, stress, irregular menstruation, mechanical stimulation, and cosmetics. However, in any case, in the pathogenesis of dandruff and itching, PO at the lesion site is
Preventing the inhabitation (invasion/growth) of dandruff, itching,
It is considered to be very important in treatment.

Furthermore, dandruff consists of sebaceous gland secretions, sweat gland secretions, peeled substances from the epidermal layer, etc. 1 It usually occurs due to increased secretion of sebaceous glands, etc., and is also promoted by the proliferation of bacteria on the skin, especially PO. It is said that

Therefore, scalp and hair cosmetics containing antibacterial agents and bactericidal agents that inhibit the growth of PO have traditionally been used to treat dandruff,
It has been used to prevent itching, and a typical example is in hair shampoo. Zinc pyrithione can be used.

However, when looking at many anti-dandruff antibacterial drugs, not just zinc pyrithione, they are not all-purpose, and some people are effective and some are not, and some people do not work after using it for about a week, or even longer. Some people tend to experience an increase in dandruff when using it over and over, and one of the reasons for this is
There are individual differences in the amount of formulation, that is, the amount that is effective, and it has been observed that when the amount of formulation exceeds the appropriate amount, it may actually increase dandruff.

Under these circumstances, recently, there has been active application of extracts based on various naturally occurring plants that have a growth inhibiting effect on dandruff bacteria to the skin and scalp. ing.

In particular, folk medicinal herbs and herbal medicines known for their anti-dandruff and itching effects are attracting attention, and extracts obtained from plants traditionally known for their use are preferred.
It is now included in hair conditioners, shampoos, hair creams, hair tonics, etc.

However, due to the combination of these herbal medicine extracts. Among the many extracted extracts, there are extremely low-effective extracts obtained from incorrect extraction methods that do not suit the purpose, or completely ineffective extracts, based on ancient traditional effects. There are many cases in which parts are extracted and used, and many are saying that these questions need to be substantiated with concrete re-evaluation tests.

In other words, depending on the extraction method, some of these extracts may have no effect at all, and may even be effective against dandruff bacteria.
On the contrary, it is speculated that some substances exhibit a proliferative effect.

Therefore, based on these matters, the present inventors sought evidence of reliable effects in order to answer these questions.
We decided to evaluate it based on its ability to inhibit growth against PO.

This evaluation method using PO has already been disclosed by Yoshimasa (Reference: Cosmetic Journal, Volume 22, Volume 3, 1988), and according to his report, it is possible to use PO from among known plant extracts. It has been confirmed that extracts such as Physcomitrella japonica, Jasmine japonica, Stonewort, Kujin, Chamomile, etc. have a growth inhibiting effect on PO.

``Problem to be solved by the invention'' External skin preparations and cosmetics are now containing various plant extracts that are believed to be effective in preventing dandruff in Chinese medicine and folk medicine. However, as mentioned above, some of them rely on ancient history without supporting data (effectiveness effects), and in some cases, incorrectly extracted ingredients that have no effect at all ( It is thought that extracts) are often used.

Therefore, the present inventors took this opportunity to introduce herbal medicines that have traditionally been used for the skin, scalp, hair, etc., as well as herbal medicines that have been taken with the expectation of other effects. Research has begun on the search and evaluation of randomly selected extracts that can be expected to have preventive effects against dandruff.

That is, one of the present inventors disclosed in the above-mentioned publication. In accordance with the test method regarding the growth inhibitory effect on PO, we set out to develop a better PO growth inhibitor from extracts of many Japanese and Chinese herbal medicines.

In other words, by accurately screening plant-derived extracts that inhibit PO growth, we hope to use them in external preparations for the skin, scalp, and hair, as well as in cosmetics in the form of application and rubbing, which are expected to have the effect of preventing dandruff and itching. One of the objectives is to expand its use in (cosmetics).

(In search/test) In order to achieve the above-mentioned purpose, the present inventors conducted the search in advance by determining the extracting conditions of each plant.

The extract obtained from each extraction condition was divided into the following four types, and the extract obtained from each extraction condition was used as a sample and added to a culture system of Dandruff bacteria: PO to determine the presence or absence of a strong or weak inhibitory effect on growth.

(Sample for screening) ■Aqueous type extract using water alone.

■Extract from a mixture of water and ethanol.

■Extract with ethanol alone.

■Essential oil (volatile components) obtained by steam distillation.

As a result, even with the same ultra-thickness (plant), the difference in extraction method is that an extract with no inhibitory effect can be obtained.

What is common to many plants is that, although there are some special exceptions, the growth-inhibiting component against PO is obtained by the above-mentioned extraction method (2). The extract/essential oil obtained by steam distillation and the component soluble in ethanol according to (■), these two extracts contain many components that have an inhibitory effect on PO growth. It was found that extracts obtained alone or in mixtures with a low mixing ratio of ethanol had almost no effect. In other words, regarding the solvent used in extraction, the above-mentioned point (2) applies. Regarding the concentration relationship between water and ethanol, it was found that using ethanol alone or as the concentration of ethanol increases, an extract containing more components that inhibit the growth of PO can be obtained. .

Therefore, the present inventors have come to regard the above-mentioned extraction methods (1) and (2) as a means of obtaining an extract containing one effective PO growth-inhibiting component in plants.

In other words, as a basic extraction condition for obtaining a Po growth inhibitor, in the present invention, various Japanese and Chinese herbal medicinal plants are randomly selected under the extraction conditions shown in (■) to (■) above, and a Po growth inhibitor with excellent effects is selected. He was involved in the discovery and development of inhibitors.

As a result, as specified below, we have succeeded in using an extract obtained from plant materials as a Po growth inhibitor.

〉Construction of the Invention The present invention relates to the present invention, which is based on the invention, Essential oil obtained by steam distillation based on Juyaku, or an extract obtained by adding ethanol to the residue after obtaining the essential oil components and immersing and eluting it, or an essential oil obtained previously. It is expected to be effective in preventing dandruff and itching as it contains a growth inhibitor of PO, which is made by diluting the ingredients in ethanol or adding the above-mentioned herbal medicine to the above-mentioned herbal medicine, soaking it in ethanol, and adding the eluted extract. ,
Consists of external skin preparations or cosmetics for the skin, scalp, and hair.

"Means for solving the problem" (a) Test method Test bacterial species: Vityrosvorum opal (IFo 0
656) was cultured on a polydextrose agar medium containing 5% Nikkor TMGO-5 (manufactured by Nikko Chemical Co., Ltd.) on a polydextrose agar medium (manufactured by Rasui Co., Ltd.), and 3 platinum loops were taken and placed in 5 ml (l) of physiological saline containing 0.7% Twin 80. to obtain a Vitilosvorum opal suspension.

This Pityrosporum Opal suspension was added to a polydextrose plate medium containing 5% Nikkor TMGO-5 (9%
0 m m ) by smearing 20 uQ.

After 30 minutes, place a disk for antibiotic titer measurement in the center of the medium, drop 30 uβ of the sample (each plant extract) onto it,
After incubation at 37° C. for 48 hours, the diameter of the formed block was measured.

(b) Results The results of the growth inhibition effect on PO are shown below (Table 1).

Note that the Po growth inhibitors (extracts) made of each plant extract shown in Table 1 have the effects of those obtained in Production/Extraction Examples 1 to 20 described later.

In addition, in the final evaluation, there were many discs with a disc diameter of 8 mm and an inhibiting inner diameter of 1 mm or less, but these were excluded here as they were considered to have no growth inhibiting effect.

"Table 1" Effect of plant extracts on inhibiting the growth of Vityrosvorum on opal. In other words, in Table 1, there are the following: Other plants that have the same growth-inhibiting effect on Po as the extracts of chamomile, kujin, etc. We were able to select extracts of various types: , Nikuzuku, Sekkoppoku, Izui, Sansounin, Bofuu or Hamabofu, and Juyaku.

Among them, it was found that the following plants, in particular, have a strong inhibitory effect.

The extract obtained using the specified extraction method according to the present invention can be effective as a Po growth inhibitor by incorporating a small amount into the formulation, and can be used in shampoos, conditioners, hair tonics, and shampoos for the scalp. It was available in a variety of dosage forms, including creams, hair ticks, hair pomades, and skin lotions, creams, and milky lotions. It can be used by incorporating it into external skin preparations and cosmetics.

(Approximate amount of compounding amount) The extract: Po growth inhibitor according to the present invention can be used as a compounding agent for preventing dandruff and itching.1 The usual compounding amount is 0.1- 0.5%,
Depending on the extract, 0. There are some products that can be expected to be effective by containing about 0.05% of Ol in the formulation.

In the present invention, there is no specific upper or lower limit to the amount to be blended into the formulation, but for example, when only essential oil components obtained by steam distillation are blended into the formulation, 0.
A concentration of about 0.01 to about 0.05% to about 0.1% can sufficiently prevent dandruff and itching that accompanies dandruff.

In addition, the Po growth inhibitor made from the plant extract according to the present invention can be used in all kinds of cosmetics, from solution-type products to creams, emulsions, foundations, lipsticks, shampoos, conditioners, etc. for the skin and scalp.・Can be added to the formulation of products for hair, etc.

For specific formulations, for example, see the following publications:
Compatible with various uses. Since prescription examples are shown, they can be used according to their addition methods.

(Location of references for prescriptions) Science of fragrances and cosmetics: Back 1) Osamu et al. / October 5, 1980: Published by Koyo Shoten (Commentary on plants of extraction origin) The plants used in the present invention are herbal medicines in Chinese medicine. Since there are many names, they are listed below using their Japanese names.

■Shoukikyo/Shozonoka: This is the dried mature fruit of the Magnoliaceae family.

■ Oriental aurean/Oren: This is the dried rhizome of Orennium cerevisiae, a member of the Ranunculaceae family, from which the roots have been removed.

■ Ginger/raw form: The rhizome of ginger, a member of the Zingiberaceae family, is left as it is, or the cork skin is removed, or it is steamed and dried.

Qingpi/Chinpi: This is the dried mature or immature peel of Lansher mandarin, a member of the Rutaceae family.

Spruce/Orange Peel: This is the dried peel of the mature fruit of the Rutaceae family.

Taisan/Garlic: Garlic of the lily family (Allium 5ativu*
The bulbs of L and L are dried as they are or after blanching.

Hatsuka/thin cargo : This is the above-ground part of the mint of the Lamiaceae family or its interspecific hybrids.

Perilla/Shiso: The dried seeds of Chilimenjiso and its varieties, which belong to the Lamiaceae family.

Shisoyou/Shiso leaves : Fresh leaves of Chilimenjiso and its varieties belonging to the Lamiaceae family.

Cinnamon bark: The dried bark of cinnamon bark and other related plants of the Lauraceae family.

Cornelian cornelian/Yansai Ei : It is the dried fruit of cornelian cornelia, a member of the Cornus family.

Nikuzuku/Nikuduna: Seeds from the Nikuzuku family, with the aril and seed coat removed.

Sekkotsuboku/Bone-bonding book: Dried stems of Sambucus, a member of the Honeysuckle family.

Izui/wilt: Polygonatu+m o of the Liliaceae family.
fficinale ALL, l rhizomes or steam-dried.

Sansounin/Sour date seed: Dried seeds of Sanebutonameno, a member of the Blackthorn family.

Glehnia 1itto: Glehnia 1itto of the Umbelliferae family
ralisF, Sch+m1dt et Mique
1. root and 1. dried root, or 2.
Windbreak: Siler divaricat (Apiaceae)
Dried roots of Benth, et Hook, fil).

■Illciu+mv: Illciu+m v
Dried mature fruit of eru+*Hook, fil, l.

■ Juyaku/Juyaku: Dried whole plant with roots attached to Houtodyami, a member of the Hemitaceae family.

(Disclosure of basic manufacturing method) [1] Using any one or more of the above ① to 1 as a raw material, the essential oil components are preparatively separated using a known steam distillation apparatus, and then the essential oil components are fractionated. Add ethanol to the leftover pickles and soak for 2 to 3 days. Add any amount of the essential oil component obtained earlier to the ethanol solution to make a PO growth inhibitor, or use only the essential oil component. Diluted in ethanol to make PO growth inhibitor.

[21 The extraction procedure is the reverse of that shown in [1] above.
First, perform immersion extraction with ethanol to obtain a solution, and then apply the residue to a steam distillation device to extract the essential oil component.Add the desired amount to the ethanol immersion solution. This makes it a po5 growth inhibitor.

[3] The essential oil components obtained by the above [1-2] are as follows.

It can be used directly as it is as a PO growth inhibitor. Furthermore, any amount can be added to the formulation of external preparations containing various known oils and fats.

Alternatively, it can be added to a base agent for cosmetics containing known fats and oils or to the formulation of known cosmetics to serve as a po growth inhibitor.

[4] Add any amount of the essential oil components obtained in [1 to 2] above to ethanol to make a PO growth inhibitor [5] Add the essential oil components obtained in [1 to 21] above to cyclodextrin. Adsorption to: Inclusion, processing into powder form and making it into a PO growth inhibitor.

Below, in the present invention, an example of production/extraction of a solution-type PO growth inhibitor obtained by the simplest method based on each identified plant is shown, that is, the above (Table 1) The data of the PO growth inhibition test disclosed in
Each of these discloses the effects of plant extracts obtained by the methods shown below.

(Manufacturing/Extraction Example 1) Steam distillation is carried out on 1 kg of Aspergillus to extract and fractionate essential oil components.Next, 1 OI2 of ethanol is added to this residue, and the mixture is heated at room temperature - day and night. After being left to stand, centrifugation is performed to separate the extracted extract.

Next, the essential oil component obtained above is mixed with this extracted extract to prepare a PO growth inhibitor.

(Manufacture/Extraction Example 2) 10 m2 of ethanol is added to 1 kg of oleracea, and the mixture is left to stand at room temperature day and night, and then centrifuged to separate the extracted extract.

Incidentally, 1 off of water is added to this residue, extraction is performed again in the same manner, and mixed with the above-mentioned extracted extract to obtain 10 growth inhibitors.

(Production/Extraction Example 3) Steam distillation is performed on 1 kg of ginger to extract and fractionate the essential oil components.Next, 10 I2 of ethanol is added to this residue and left at room temperature - day and night. After that, centrifuge and separate the extracted extract.

Next, the essential oil component obtained above is mixed with this extracted extract to prepare 10 growth inhibitors.

(Production/Extraction Example 4) Steam distillation is performed on 1 kg of chimpi to extract and fractionate the essential oil components.Next, ethanol 1Oβ is added to this residue and left at room temperature day and night. , centrifuge to separate the extracted extract.

Next, the essential oil component obtained above is mixed with this extracted extract to prepare 10 growth inhibitors.

(Manufacturing/Extraction Example 5) 1 kg of spruce is subjected to steam distillation to extract and fractionate essential oil components.Next, 1 OI2 of ethanol is added to this residue and left at room temperature day and night. , centrifuge to separate the extracted extract.

Next, the essential oil component obtained above is mixed with this extracted extract to prepare 10 growth inhibitors.

(Production/Extraction Example 6) Add 10Q of ethanol to IKg of Taisan,
After being left at room temperature for days and nights, it was centrifuged to obtain an extract, which was used as 10 growth inhibitors.

(Production/Extraction Example 7) Steam distillation is performed on 1 kg of peppermint to extract and fractionate the essential oil components.Next, 1 Oe of ethanol is added to this residue and left at room temperature day and night. , centrifuge to separate the extracted extract.

Next, the essential oil component obtained above is mixed with this extracted extract to prepare 10 growth inhibitors.

(Manufacture/Extraction Example 8) The first step is to perform steam distillation to extract and fractionate 1M oil component based on 1 kg of perilla or perilla perilla.

To this residue, 1 Oe of ethanol was added, and the mixture was left to stand at room temperature day and night, and then centrifuged.

Separate the extract.

Next, the essential oil component obtained above is mixed with this extracted extract to prepare 10 growth inhibitors.

(Production/extraction example 9) Steam distillation is performed on 1 kg of cinnamon bark.

Next, the essential oil components are extracted and fractionated, and for this residue part,
Add 1OI2 of ethanol and keep at room temperature.

After being left for day and night, centrifugation is performed to separate the extracted extract.

Next, the essential oil component obtained above is mixed with this extracted extract to prepare 10 growth inhibitors.

(58! Preparation/Extraction Example 10) Steam distillation was performed on 1 kg of cornelian cornflower, and the essential oil components were extracted and fractionated.Next, 10Q of ethanol was added to this residue, and the mixture was left at room temperature overnight. Thereafter, centrifugation is performed to obtain a cornelian extract, and the essential oil component obtained above is mixed with this extracted extract to prepare 10 growth inhibitors.

(Production/Extraction Example 11) Steam distillation is performed on IKg of Nikuzuku to extract and fractionate essential oil components.Next, 10J2 of ethanol is added to this residue at room temperature.

- After being left for day and night, centrifuge and separate the extracted extract.

Next, the essential oil component obtained above is mixed with this extracted extract to prepare 10 growth inhibitors.

(Manufacture/Extraction Example 12) Ethanol 104 was added to Ikg of Sekkotsuboku, and the mixture was allowed to stand at room temperature day and night, and then centrifuged to obtain 10 growth inhibitor.

(Production/Extraction Example 13) Add 1oI2 of ethanol to 1Kg of Izui,
After being left at room temperature for days and nights, it was centrifuged to obtain an extract, which was used as 10 growth inhibitors.

(Manufacture/Extraction Example 14) Ethanol IOe is added to 1 kg of sunflower nin, and after being allowed to stand at room temperature day and night, centrifugation is performed to obtain an extracted extract, which is used as a PO growth inhibitor.

(Manufacture/Extraction Example 15) Steam distillation is performed on 1 kg of bofu to extract and fractionate essential oil components.Next, ethanol IO is added to this residue and left at room temperature - day and night. After that, centrifuge and separate the extracted extract.

Next, the essential oil component obtained above is mixed with this extracted extract to prepare a PO growth inhibitor.

(Production/Extraction Example 16) Steam distillation is performed on IKg of fennel, and the essential oil components are extracted and fractionated.Next, 1OI2 of ethanol is added to this residue, and after leaving it at room temperature for a day and night,
Centrifuge and separate the extract.

Next, the essential oil component obtained above is mixed with this extracted extract to prepare a PO growth inhibitor.

(Production/Extraction Example 17) Steam distillation is performed on Ikg of Juyaku to extract and fractionate essential oil components.Next, lOi of ethanol is added to this residue, and after leaving it at room temperature for a day and night, Centrifuge and separate the extract.

Next, the essential oil component obtained above is mixed with this extracted extract to prepare a PO growth inhibitor.

F Confirmation of anti-dandruff and anti-itch effect (a) Test method In the test, first, in the formulation of hair shampoo as shown in the following table (Table 2), the products obtained in the above production/extraction example were However, we produced hair shampoos containing two to three PO growth inhibitors and those without additives, which were used for people who tend to have dandruff on their hair, and people who suffer from dandruff and have itching (20 people). We decided to compare and evaluate the effects of these products after using them for about 2i.

The results were as shown in the following tables (Tables 3 and 4).

That is, the numbers shown in Tables 3 and 4 are the results of the responses received regarding the effects of using each He7 Shampoo, expressed in terms of the number of people.

(b) Results As shown in Table 3, the extract according to the present invention: He7 shampoo containing a PO growth inhibitor clearly has the effect of suppressing dandruff, even when compared to additive-free hair shampoo. I was able to estimate it.

Also, as shown in Table 4, a hair shampoo containing the extract of the present invention: PO growth inhibitor.

It was thought to have a soothing effect on itching compared to additive-free hair shampoo.

“Table 2” Hair shampoo prescription "Table 3" Anti-dandruff effect (Number of respondents) still, In Tables 3 and 4, The above-mentioned fi/extraction example From inside.

Some of the plant extracts: Regarding the po growth inhibitor, we have shown the effects of using them when added to the 7 shampoos. Any of the methods obtained by methods [11 to [5] is effective.

(C) Effects of the Invention The present invention is based on the identified plant herbal medicine, and has discovered and made available a growth inhibitor for PO.

That is, when the extract obtained from the plant according to the present invention is used in external preparations for the skin, scalp, and hair, or cosmetics, the expected effects include: (1) dandruff on the skin and scalp; Prevention of itching.

Useful for treatment.

(2) According to the PO growth inhibitor according to the present invention, when necessary during the formulation of cosmetics for skin or hair.

Surfactants, humectants, lower alcohols, thickeners, fragrances,
Known and commonly used ingredients such as antioxidants, chelating agents, dyes, and preservatives can be used in any combination, and there are no special contraindications to their combination.

■ The PO growth inhibitor according to the present invention can prevent not only dandruff and itching, but also seborrheic eczema and hair loss on the head, and has the effect of promoting blood flow in the peripheral blood vessels of the A side and skin. .

■ The PO growth inhibitor according to the present invention can be used in small amounts and at the same time, for formulations containing various lipids in the formulation.
It exerts an antioxidant effect on fats and oils. That is,
The PO growth inhibitor according to the present invention is characterized by having an antioxidant effect on sebum and fats and oils, inhibiting the production of lipid peroxides, and also serving as a stabilizer.

Claims (1)

[Claims] (1) Extraction raw materials from plants are known as Japanese and Chinese herbal medicines, such as Aspergillus or Orientalum, Oriental medicinalum, Citrus perilla, Chinpi, Taisang, Mentha, Perilla or Perilla, Spruce, Keihi, Cornelius, Cucumber, Cucumber,
A dandruff product containing a dandruff fungus growth inhibitor containing the plant extract components obtained in the following A to E, based on at least one of the following: External skin preparations or cosmetics for the skin, scalp, and hair that are expected to have a preventive effect. A: Essential oil obtained by steam distillation. B: A solution obtained by adding ethanol to the residue obtained from obtaining A above and immersing it. C: A solution obtained by further diluting the above A with ethanol D: A solution obtained by adding ethanol to the above-mentioned herbal medicine and soaking it. E: A solution obtained by mixing two or more of the above A to D.