KR102028382B1

KR102028382B1 - Cosmetic composition for hair and scalp comprising Ginsenoside

Info

Publication number: KR102028382B1
Application number: KR1020120125392A
Authority: KR
Inventors: 김기정; 강병하; 이존환
Original assignee: (주)아모레퍼시픽
Priority date: 2012-11-07
Filing date: 2012-11-07
Publication date: 2019-10-04
Also published as: KR20140058923A

Abstract

The present invention relates to a hair or scalp cosmetic composition containing ginsenoside Rg1 and ginsenoside Re, and more particularly, to a hair or scalp containing ginsenoside Rg1 and ginsenoside Re extracted in ginseng at an appropriate ratio. It relates to a cosmetic composition for. Hair or scalp cosmetic composition according to the present invention acts on the hair roots, hair and scalp to nourish the hair root and hair and to restore the damaged hair and scalp to a healthy hair growth effect, excellent hair loss prevention effect.

Description

Cosmetic composition for hair or scalp containing ginsenosides

In the modern society that emphasizes beauty, various studies are being actively conducted to prevent and treat hair loss and promote hair growth for men or women who suffer from severe mental pain due to various causes of hair loss.

Ginseng extract is a complex composed of various ingredients, and it is known that ginseng extracts are effective in preventing hair loss, and there is a lack of understanding on which components of the extract exhibit such effects by what mechanism and synergistic effects between ginsenoside components. The effect was not great. Currently known ginseng ginsenosides of 30 kinds can be obtained ginsenosides of various types and contents depending on the type, site, harvesting time, extraction method of ginseng.

Republic of Korea Patent Publication No. 101114097

Therefore, the inventors of the present invention have a very good hair loss preventing effect when containing ginsenoside Rg1 and ginsenoside Re, and when the ginsenoside Rg1 and ginsenoside Re are contained in a specific weight ratio, the hair loss prevention effect is more excellent. The present invention has been completed by finding a marked improvement.

Accordingly, an object of the present invention is to provide a cosmetic composition for hair or scalp containing ginsenoside Rg1 and ginsenoside Re. It is also an object of the present invention to provide a hair or scalp cosmetic composition containing ginsenoside Rg1 and ginsenoside Re in a weight ratio of 1: 1 to 1: 5. Hair or scalp cosmetic composition according to the present invention exhibits excellent hair growth promotion and hair loss prevention effect by the synergistic effect of the ginsenoside Rg1 and ginsenoside Re.

The present invention provides a cosmetic composition for hair or scalp containing ginsenoside Rg1 and ginsenoside Re. The ginsenoside Rg1 and ginsenoside Re may be represented by the following Chemical Formula 1.

Hereinafter, the present invention will be described in more detail.

The cosmetic composition for hair or scalp according to the present invention contains ginsenoside Rg1 and ginsenoside Re. The content ratio of the ginsenoside Rg1 and the ginsenoside Re is preferably 1: 1 to 1: 5 by weight. When the content ratio is less than 1: 1, it is difficult to exhibit the anti-hair loss synergistic effect, and when it exceeds 1: 5, the synergy effect no longer increases.

In one embodiment of the present invention, the ginsenoside Rg1 and ginsenoside Re may contain a total content of 0.01% by weight or more based on the total weight of the composition. In another embodiment of the present invention, the ginsenoside Rg1 and ginsenoside Re may contain a total content of 10 wt% or less or 1 wt% or less with respect to the total weight of the composition. In another embodiment of the present invention, the ginsenoside Rg1 and ginsenoside Re may contain a total content of 0.01% to 10% by weight, more preferably 0.01% to 1% by weight. . If the content is less than 0.01% by weight, it is difficult to show the hair loss prevention effect, if it exceeds 10% by weight there is a problem that precipitates in the formulation is precipitated to reduce the effect.

Ginsenoside Rg1 and ginsenoside Re according to the present invention can be extracted from ginseng, the ginseng may be root, stem, leaf or pulp of ginseng, preferably may be extracted from the root or leaf of ginseng. . However, the present invention is not limited by these extraction sites.

There is no particular limitation in formulating the cosmetic composition for hair or scalp according to the present invention, but hair tonic, hair nourishing cosmetics, hair essence, hair serum scalp treatment, hair treatment, hair conditioner, hair shampoo or hair lotion, etc. It may be a cosmetic composition having a formulation of.

In addition, in each formulation, other ingredients in addition to the above-mentioned essential ingredients may be appropriately selected and blended by those skilled in the art without difficulty according to the kind or purpose of use of other external preparations.

For example, the shampoo composition for hair provided in the present invention can be used by adding an appropriate component according to the kind. Specifically, in the shampoo composition consisting of conventional surfactants and preservatives, preservatives, thickeners and viscosity adjusting agents, pH adjusting agents, fragrances, dyes, hair conditioning agents and water, the synthetic surfactants used in the present invention are anionic, Any selected from amphoteric, nonionic surfactants is possible. The synthetic surfactant may be contained in an amount of 10 to 70% by weight, preferably 10 to 30% by weight, based on the total weight of the composition.

The synthetic anionic surfactants may use alkyl and alkyl ether sulfate, and specific examples thereof include sodium lauryl sulfate, lauryl ammonium sulfate, lauryl sulfate triethanolamine, polyoxyethylene lauryl sulfate, polyoxyethylene lauryl ammonium sulfate, and the like. Can be mentioned.

The synthetic amphoteric surfactant may be alkyl betaine and alkyl amidopropyl betaine, specific examples are cocodimethyl carboxymethyl betaine, lauryldimethyl carboxymethyl betaine, lauryldimethyl alpha-carboxyethyl betaine, cetyl Dimethyl carboxymethyl betaine, cocamidopropyl betaine, etc. are mentioned.

The synthetic nonionic surfactant may use alkanol amide and amine oxide, and specific examples thereof include lauryl diethyl amine oxide, palm oil alkyldimethyl amine oxide, lauric acid diethanolamide, palm oil fatty acid diethanolamide, palm oil fatty acid mono Ethanolamide, and the like.

The above-mentioned surfactants can be selectively used alone or in combination in the hair cosmetic composition of the present invention.

Preservatives may be used by mixing together one or more selected from the group consisting of methyl paraoxybenzoate, propyl paraoxybenzoate, sodium benzoate, methylchloroisothiazolinone, methylisothiazolinone and sodium benzoate.

As the viscosity modifier, coamide amide (CME), cocaramide die (CDE), sodium chloride, and the like, which are amide based nonionic surfactants, can be used.

As the pH adjusting agent, sodium phosphate, disodium phosphate, citric acid, sodium citrate and the like can be used.

As a hair conditioner, it is good to use a dimethicone base, cationic polymer, etc. individually or in mixture of 2 or more types.

Moreover, the hair conditioner composition provided by this invention can be used, adding a suitable component according to the kind. Specifically, cationic surfactants may contain tertiary amidoamines, quaternary ammonium compounds, high melting point compounds, silicone compounds, and optional components as preservatives, thickeners, viscosity regulators, pH adjusters, fragrances, etc. as conventional conditioner components. have.

In the above hair conditioner composition, the quaternary ammonium compound as the cationic surfactant is alkyl (14-22) trimethyl ammonium chloride, dialkyl (14-22) dimethyl ammonium chloride, hydrogenated tallow alkyl trimethyl ammonium chloride, ditallow alkyl dimethyl ammonium chloride Tertiary amidoamines include, for example, cocaamidopropyl dimethylamine, stearamidopropyl dimethylamine, behenamidopropyl dimethylamine, oleamidopropyl dimethylamine, isostearamidopropyl dimethyl Amines and the like. The amines are preferably neutralized with acids such as L-glutamic acid, lactic acid, hydrochloric acid, malic acid, succinic acid, acetic acid, fumaric acid, citric acid and EDTA. These cationic surfactants may be used singly or in mixture of two or more thereof, using 1 to 30% by weight, preferably 5 to 20% by weight, based on the total weight of the total composition.

The high melting point compound is a compound consisting of fatty alcohols, fatty acids, fatty alcohol derivatives, hydrocarbons and the like, and mixtures thereof. For example, cetyl alcohol, stearyl alcohol, cetostearyl alcohol, etc. are included in the total weight of the conditioner composition. It is preferable to use 1-10 weight% with respect to.

Silicone compounds used in the present invention include polyalkylsiloxanes, polyarylsiloxanes, polyalkylarylsiloxanes, polyethersiloxane copolymers and mixtures thereof, cyclopolysiloxanes and suitable alkyl amino substituted compounds, amodimethicone and the like. It is preferable to use 1 to 10% by weight based on the total weight of the conditioner composition.

The cosmetic composition for hair or scalp according to the present invention contains ginsenoside Rg1 and ginsenoside Re, and is excellent in promoting hair growth and preventing hair loss, and ginsenoside Rg1 and ginsenoside Re are 1: 1 to 1: In the optimal weight ratio of 5, the synergistic effect of the ginsenoside Rg1 and the ginsenoside Re shows an excellent hair growth promoting effect and hair loss prevention effect.

Hereinafter, although an Example is given and this invention is demonstrated in detail, this invention is not limited only to these examples.

Test Example 1 Evaluation of Efficacy of Hair Loss Prevention of Ginsenoside

In order to confirm the hair loss prevention efficacy of the five ginsenosides of ginsenoside Rg1, ginsenoside Rb1, ginsenoside Rc, ginsenoside Rd, and ginsenoside Re, the 7-week-old mouse (C57BL / 6), etc. Remove the hair from the area, choose clean skin on the back area, and select 10 animals for each substance group, and each weight of ginsenoside Rg1, ginsenoside Rb1, ginsenoside Rc, ginsenoside Rd, and ginsenoside Re each 1% by weight The solution was applied for 21 days at 150 μl per individual mouse group and washed. After 23 days, the weight of the newly grown hair was measured and compared, and the results are shown in Table 1.

Treatment group Average hair weight (mg) Ginsenoside Rb1 31.90 Ginsenoside Rc 33.72 Ginsenoside Rg1 41.39 Ginsenoside Re 44.02 Ginsenoside Rd 30.92

In the results of Table 1, in the experimental group coated with ginsenoside Rg1 and ginsenoside Re, respectively, the hair growth effect was remarkable as compared to the case where ginsenoside Rb1, ginsenoside Rc, and ginsenoside Rd were respectively applied. It can be seen.

[Examples 1-5 and Comparative Examples 1-4]

The shampoo compositions of Examples 1 to 5 and Comparative Examples 1 to 4 were prepared according to the compositions shown in Table 1 below.

Ingredient (% by weight) Example 1 Example 2 Example
3 Example
4 Example
5 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Polyquaternium-10 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 Sodium laureth sulfate 20 20 20 20 20 20 20 20 20 Ginsenoside Rg1 0.3 0.2 0.15 0.12 0.1 0.6 - 0.087 0.4 Ginsenoside Re 0.3 0.4 0.45 0.48 0.5 - 0.6 0.513 0.2 incense 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 Methylparaben 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 Coca MIDA 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 Cetyl alcohol 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 Sodium chloride 0.8 0.8 0.8 0.8 0.8 0.8 0.8 0.8 0.8 Purified water To 100 To 100 To 100 To 100 To 100 To 100 To 100 To 100 To 100

Each component was mixed according to the composition shown in Table 2 to prepare the shampoo compositions of Examples 1 to 5 and Comparative Examples 1 to 4 according to a conventional shampoo manufacturing method. Ginsenoside Rg1 and Ginsenoside Re were obtained from Ambo Research Institute (536-9 Bongmyeong-dong, Yuseong-gu, Daejeon). Comparative Examples 1 and 2 are compositions containing only ginsenoside Rg1 or ginsenoside Re, respectively, and comparative example 3 is a composition in which the weight ratio of ginsenoside Rg1 and ginsenoside Re is 1: 6.

Test Example 2 Hair Loss Prevention Effect Test

Thirty-four subjects with initial hair loss were tested for hair loss prevention for 16 weeks. By dividing the 54 subjects into nine groups of six people each, the number of hairs dropped when the hair was washed before starting to use the composition was collected, and the number was measured, and the compositions of Examples 1 to 5 and Comparative Examples 1 to 4 were once daily After 16 weeks of use, hair loss was collected and counted again when hair was washed 16 weeks later, and the results are shown in Table 3.

Treatment group Fallout Average Hair Count () Before use 16 weeks later Example 1 (Rg1: Re = 1: 1) 93.31 70.56 Example 2 (Rg1: Re = 1: 2) 91.50 69.89 Example 3 (Rg1: Re = 1: 3) 94.30 71.50 Example 4 (Rg1: Re = 1: 4) 93.91 70.39 Example 5 (Rg1: Re = 1: 5) 90.47 67.88 Comparative Example 1 (Rg1 only) 92.36 85.69 Comparative Example 2 (Re only) 89.89 84.32 Comparative Example 3 (Rg1: Re = 1: 6) 92.65 82.11 Comparative Example 4 (Rg1: Re = 2: 1) 93.64 83.97

In the results of Table 3, it can be seen that when treated with the composition of Examples 1 to 5 according to the present invention, the number of dropped hairs is significantly reduced compared to Comparative Examples 1 to 4.

Claims

As a cosmetic composition for preventing hair loss containing a mixture of ginsenoside Rg1 and ginsenoside Re as an active ingredient,
The mixture is ginsenoside Rg1 and ginsenoside Re, characterized in that the mixture of 1: 1 to 1: 5 by weight, hair loss prevention cosmetic composition.

According to claim 1, wherein the mixture is characterized in that to increase the average hair weight, hair loss preventing cosmetic composition.

According to claim 1, wherein the content of the mixture is characterized in that 0.01 to 10% by weight based on the total weight of the composition, cosmetic composition for preventing hair loss.

According to claim 3, The content of the mixture is characterized in that from 0.01% to 1% by weight based on the total weight of the composition, cosmetic composition for preventing hair loss.

According to claim 1, wherein the mixture is ginsenoside Rg1 and ginsenoside Re, characterized in that the mixture of 1: 5 by weight, hair loss prevention cosmetic composition.