KR20140058923A - Cosmetic composition for hair and scalp comprising ginsenoside - Google Patents

Cosmetic composition for hair and scalp comprising ginsenoside Download PDF

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KR20140058923A
KR20140058923A KR1020120125392A KR20120125392A KR20140058923A KR 20140058923 A KR20140058923 A KR 20140058923A KR 1020120125392 A KR1020120125392 A KR 1020120125392A KR 20120125392 A KR20120125392 A KR 20120125392A KR 20140058923 A KR20140058923 A KR 20140058923A
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hair
ginsenoside
scalp
cosmetic composition
present
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KR102028382B1 (en
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김기정
강병하
이존환
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(주)아모레퍼시픽
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/63—Steroids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures

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  • Health & Medical Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Birds (AREA)
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  • Microbiology (AREA)
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  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Cosmetics (AREA)

Abstract

The present invention relates to a cosmetic composition for hair or scalp containing ginsenoside Rg1 and ginsenoside Re. More particularly, the present invention relates to a hair or scalp cosmetic composition containing ginsenoside Rg1 and ginsenoside Re, And more particularly to a cosmetic composition for cosmetics. The cosmetic composition for hair or scalp according to the present invention acts on hair roots, hair and scalp to supply nourishment to hair roots and hair, restores damaged hair and scalp healthily, and is excellent in hair growth effect and exhibits excellent hair loss prevention effect.

Description

[0001] The present invention relates to a cosmetic composition for hair or scalp containing ginsenoside,

The present invention relates to a cosmetic composition for hair or scalp containing ginsenoside Rg1 and ginsenoside Re. More particularly, the present invention relates to a hair or scalp cosmetic composition containing ginsenoside Rg1 and ginsenoside Re, And more particularly to a cosmetic composition for cosmetics. The cosmetic composition for hair or scalp according to the present invention acts on hair roots, hair and scalp to supply nourishment to hair roots and hair, restores damaged hair and scalp, and exhibits excellent hair growth effect and excellent hair loss prevention effect.

Various studies are actively conducted in order to prevent hair loss and to promote hair growth for men or women suffering from severe hair loss due to hair loss due to various causes in a modern society where beauty is emphasized.

Ginseng extract is a complex composed of various components. It is known that ginseng extracts have anti-hair loss effect. However, it is known that any of the components of extracts show such effect by the mechanism, and the synergy effect of ginsenoside components is not understood The effect was not significant. Currently known ginseng ginsenoside is about 30 kinds, and ginsenosides of various kinds and contents can be obtained depending on kinds, parts, sampling period and extraction method of ginseng.

Korean Patent Registration No. 101114097

Thus, the inventors of the present invention found that the hair loss preventing effect is excellent when the ginsenoside Rg1 and ginsenoside Re are contained, and when the ginsenoside Rg1 and ginsenoside Re are contained at a specific weight ratio, And the present invention has been completed.

Accordingly, an object of the present invention is to provide a cosmetic composition for hair or scalp containing ginsenoside Rg1 and ginsenoside Re. It is also an object of the present invention to provide a cosmetic composition for hair or scalp which contains ginsenoside Rg1 and ginsenoside Re in a weight ratio of 1: 1 to 1: 5. The cosmetic composition for hair or scalp according to the present invention exhibits excellent hair growth promotion and hair loss prevention effect by synergy effect of ginsenoside Rg1 and ginsenoside Re.

The present invention provides a cosmetic composition for hair or scalp containing ginsenoside Rg1 and ginsenoside Re. The ginsenosides Rg1 and ginsenoside Re may be represented by the following formula (1).

Figure pat00001

Hereinafter, the present invention will be described in more detail.

The cosmetic composition for hair or scalp according to the present invention contains ginsenoside Rg1 and ginsenoside Re. The content ratio of ginsenoside Rg1 and ginsenoside Re is preferably 1: 1 to 1: 5 by weight. When the content ratio is less than 1: 1, the synergy effect of preventing hair loss is hardly exhibited, and when it exceeds 1: 5, the synergy effect is not increased any more.

 In one embodiment of the present invention, the total content of the ginsenosides Rg1 and ginsenoside Re may be 0.01% by weight or more based on the total weight of the composition. In another embodiment of the present invention, the ginsenosides Rg1 and ginsenoside Re may contain up to 10% by weight or up to 1% by weight, based on the total weight of the composition. In another embodiment of the present invention, the total content of the ginsenosides Rg1 and ginsenoside Re may be from 0.01% by weight to 10% by weight, more preferably from 0.01% by weight to 1% by weight . If the content is less than 0.01% by weight, the effect of preventing hair loss is hardly exhibited. If the content is more than 10% by weight, precipitation and precipitation in the formulation may reduce the effect.

The ginsenosides Rg1 and ginsenoside Re according to the present invention may be extracted from ginseng, and the ginseng may be roots, stems, leaves or flesh of ginseng, preferably extracted from roots or leaves of ginseng . However, the present invention is not limited by these extraction sites.

There is no particular limitation on the formulation of the hair or scalp cosmetic composition according to the present invention. However, it is not particularly limited to the hair tonic, hair nutrition lotion, hair essence, hair serum scarf treatment, hair treatment, hair conditioner, hair shampoo or hair lotion ≪ / RTI >

In addition, in the respective formulations, the ingredients other than the above-mentioned essential ingredients can be suitably selected and blended by those skilled in the art depending on the kind of the external preparation, the purpose of use, and the like.

For example, the hair shampoo composition of the present invention may be added with suitable components according to the type thereof. Specifically, in a shampoo composition composed of a synthetic surfactant, which is a common cleaning component, a preservative, an increasing agent and a viscosity adjusting agent, a pH adjusting agent, a perfume, a dye, a hair conditioning agent and water, the synthetic surfactant used in the present invention is anionic, Any one selected from amphoteric and nonionic surfactants is also possible. The synthetic surfactant may be contained in an amount of 10 to 70% by weight, preferably 10 to 30% by weight, based on the total weight of the composition.

As the synthetic anionic surfactant, alkyl and alkyl ether sulfates may be used. Specific examples thereof include sodium lauryl sulfate, ammonium lauryl sulfate, triethanolamine lauryl sulfate, sodium polyoxyethylene lauryl sulfate, polyoxyethylene lauryl sulfate and the like .

The synthetic amphoteric surfactant may be alkyl betaine and alkylamidopropyl betaine. Specific examples thereof include cocodimethylcarboxymethylbetaine, lauryldimethylcarboxymethylbetaine, lauryldimethyl alpha-carboxyethylbetaine, cetyl Dimethyl carboxymethyl betaine, and cocamidopropyl betaine.

As the synthetic nonionic surfactant, alkanolamide and amine oxide can be used. Specific examples thereof include lauryldiethylamine oxide, palm oil alkyldimethylamine oxide, lauric acid diethanolamide, palm oil fatty acid diethanolamide, palm oil fatty acid mono Ethanol amide and the like.

The above-mentioned surfactants can be used alone or in combination in the hair cosmetic composition of the present invention.

As the preservative, at least one selected from the group consisting of methyl parahydroxybenzoate, propyl p-hydroxybenzoate, sodium benzoate, methyl chloroisoquinolinone, methyl isothiazolinone, and sodium benzoate may be mixed and used.

As the viscosity modifier, amide type nonionic surfactants such as cocamide mie (CME), cocamide dihee (CDE), sodium chloride and the like can be used.

As the pH adjusting agent, sodium phosphate, disodium phosphate, citric acid, sodium citrate and the like can be used.

The hair conditioning agent is preferably a dimethicone base and a cationic polymer, or a mixture of two or more thereof.

In addition, the conditioner composition for hair provided in the present invention may be added with suitable components depending on the type thereof. Specifically, conventional conditioner components include cationic surfactants such as tertiary amidoamine and quaternary ammonium compounds, high melting point compounds, silicon compounds and optional components such as preservatives, thickeners, viscosity regulators, pH adjusting agents, have.

The quaternary ammonium compound as a cationic surfactant in the hair conditioning agent composition is selected from alkyl (14-22) trimethylammonium chloride, dialkyl (14-22) dimethylammonium chloride, hydrogenated tallowalkyltrimethylammonium chloride, ditallowalkyldimethylammonium chloride And the like. The tertiary amidoamine includes, for example, cocamidopropyldimethylamine, stearamidopropyldimethylamine, behenylamidopropyldimethylamine, oleamidopropyldimethylamine, isostearamidopropyldimethyl Amine and the like. The amines are preferably neutralized with acids such as L-glutamic acid, lactic acid, hydrochloric acid, malic acid, succinic acid, acetic acid, fumaric acid, citric acid and EDTA. These cationic surfactants are preferably used alone or in combination of two or more thereof in an amount of 1 to 30% by weight, preferably 5 to 20% by weight based on the total weight of the composition.

Examples of the high melting point compounds include compounds of fatty alcohol type, fatty acid type, fatty alcohol derivative, hydrocarbon type and the like and mixtures thereof, for example, cetyl alcohol, stearyl alcohol, cetostearyl alcohol and the like, By weight to 1% by weight to 10% by weight.

The silicone compounds used in the present invention include polyalkylsiloxane-based, polyarylsiloxane-based, polyalkylarylsiloxane-based, polyether siloxane copolymers and mixtures thereof with cyclopolysiloxane and suitable alkylamino substituted compounds, , Preferably 1 to 10% by weight based on the total weight of the conditioner composition.

As the preservative, at least one selected from the group consisting of methyl parahydroxybenzoate, propyl p-hydroxybenzoate, sodium benzoate, methyl chloroisothiazolinone, methyl isothiazolinone, and sodium benzoate may be mixed and used.

As the pH adjusting agent, sodium phosphate, disodium phosphate, citric acid, sodium citrate and the like can be used.

The hair or scalp cosmetic composition for hair or scalp according to the present invention contains ginsenoside Rg1 and ginsenoside Re to exert an excellent effect of promoting hair growth and hair loss and to provide ginsenoside Rg1 and ginsenoside Re in a ratio of 1: 5, the synergistic effect of the ginsenoside Rg1 and ginsenoside Re exhibits excellent hair growth promotion and hair loss prevention effect.

Hereinafter, the present invention will be described in detail by way of examples, but the present invention is not limited to these examples.

[Test Example 1] Evaluation of antiperspirant efficacy of ginsenoside

(C57BL / 6) of 7-week-old mice (C57BL / 6) in order to confirm the efficacy of five ginsenosides of ginsenoside Rg1, ginsenoside Rb1, ginsenoside Rc, ginsenoside Rd and ginsenoside Re The skin of the back part was removed, and 10 rats were selected for each material group. The rats were divided into daily rats each 1% by weight of ginsenoside Rg1, ginsenoside Rb1, ginsenoside Rc, ginsenoside Rd and ginsenoside Re, Solution was applied at 150 占 퐇 per individual mouse group for 21 days and then washed. The weight of newly emerged hairs after 23 days was measured and compared. The results are shown in Table 1.

Treated group Average hair weight (mg) Ginsenoside Rb1 31.90 Gin Senocide Rc 33.72 Ginsenoside Rg1 41.39 Gin Senocide Re 44.02 Gin Senocide Rd 30.92

In the results shown in the above Table 1, in the case of the experiment group in which ginsenoside Rg1 and ginsenoside Re were respectively applied, remarkable hair growth effect was observed as compared with the case of applying ginsenoside Rb1, ginsenoside Rc and ginsenoside Rd respectively .

[Examples 1 to 5 and Comparative Examples 1 to 4]

The shampoo compositions of Examples 1 to 5 and Comparative Examples 1 to 4 were prepared according to the compositions shown in Table 1 below.

Component (% by weight) Example 1 Example 2 Example
3 Example
4 Example
5 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Polyquaternium-10 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 Sodium laureth sulfate 20 20 20 20 20 20 20 20 20 Ginsenoside Rg1 0.3 0.2 0.15 0.12 0.1 0.6 - 0.087 0.4 Gin Senocide Re 0.3 0.4 0.45 0.48 0.5 - 0.6 0.513 0.2 incense 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 Methyl paraben 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 Cocamide miai 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 Cetyl alcohol 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 Sodium chloride 0.8 0.8 0.8 0.8 0.8 0.8 0.8 0.8 0.8 Purified water To 100 To 100 To 100 To 100 To 100 To 100 To 100 To 100 To 100

The shampoo compositions of Examples 1 to 5 and Comparative Examples 1 to 4 were prepared according to a conventional shampoo manufacturing method by blending each component according to the composition shown in Table 2 above. Ginsenoside Rg1 and Ginsenoside Re were obtained from Ambo Laboratories (536-9 Bongmyeong-dong, Yuseong-gu, Daejeon). Comparative Examples 1 and 2 are compositions each containing only ginsenoside Rg1 or ginsenoside Re, and Comparative Example 3 is a composition wherein the weight ratio of ginsenoside Rg1 and ginsenoside Re is 1: 6.

[Test Example 2] Test for preventing hair loss

 A study on the effect of preventing hair loss was conducted for 54 weeks in subjects with an initial hair loss phenomenon for 16 weeks. The 54 subjects were divided into 9 groups of 6 subjects to collect the hair that fell off when the hair was wrapped before starting use of the composition, and the number of the hair was measured. The composition of each of the above Examples 1 to 5 and Comparative Examples 1 to 4 After 16 weeks of use, the hair was collected at the end of 16 weeks, and the number of the decidua was collected and counted. The results are shown in Table 3.

Treated group Average number of hits removed () Before use After 16 weeks Example 1 (Rg1: Re = 1: 1) 93.31 70.56 Example 2 (Rg1: Re = 1: 2) 91.50 69.89 Example 3 (Rg1: Re = 1: 3) 94.30 71.50 Example 4 (Rg1: Re = 1: 4) 93.91 70.39 Example 5 (Rg1: Re = 1: 5) 90.47 67.88 Comparative Example 1 (Rg1 alone) 92.36 85.69 Comparative Example 2 (Re alone) 89.89 84.32 Comparative Example 3 (Rg1: Re = 1: 6) 92.65 82.11 Comparative Example 4 (Rg1: Re = 2: 1) 93.64 83.97

From the results shown in Table 3, it can be seen that the number of drop hairs decreased remarkably when treated with the compositions of Examples 1 to 5 according to the present invention, as compared with Comparative Examples 1 to 4.

Claims (5)

A cosmetic composition for hair or scalp containing ginsenoside Rg1 and ginsenoside Re. The cosmetic composition for hair or scalp according to claim 1, wherein the ginsenoside Rg1 and ginsenoside Re are contained in a weight ratio of 1: 1 to 1: 5. The cosmetic composition for hair or scalp according to claim 1 or 2, wherein the ginsenoside Rg1 and ginsenoside Re are contained in an amount of 0.01 to 10% by weight based on the total weight of the composition. The cosmetic composition for hair or scalp according to claim 1 or 2, wherein the cosmetic composition is for promoting hair growth. The cosmetic composition for hair or scalp according to claim 1 or 2, wherein the cosmetic composition is for preventing hair loss.
KR1020120125392A 2012-11-07 2012-11-07 Cosmetic composition for hair and scalp comprising Ginsenoside KR102028382B1 (en)

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20170024915A (en) 2015-08-26 2017-03-08 영림영농조합법인 제주편백우드 Cosmetic composition for hair or scalp and preparation method thereof
KR20200011781A (en) 2018-07-25 2020-02-04 영남대학교 산학협력단 Cosmetic composition for improving the health of scalp comprising natural caffeine and chlorogenic acid
WO2020262933A1 (en) 2019-06-25 2020-12-30 충남대학교산학협력단 Pharmaceutical composition for preventing hair loss or promoting hair growth, comprising ginsenoside rg4 or mixture (rgx 365) of ginsenosides rg2, rg4, rg6, and rh1 as active ingredient
WO2024174889A1 (en) * 2023-02-23 2024-08-29 茵素科技(广州)有限公司 Ginsenoside composition, daily chemical, and use

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101114097B1 (en) 2008-11-25 2012-02-21 (주)아모레퍼시픽 Hair cosmetic composition containing 6 years root Panax Ginseng water
KR20120080031A (en) * 2011-01-06 2012-07-16 (주)대덕바이오 Composition for enhancing hair growth containing saponin rd and re as active ingredients
KR20120112928A (en) * 2011-04-04 2012-10-12 충남대학교산학협력단 Injectable composition for enhancing hair growth containing saponin rg1 as active ingredient

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101114097B1 (en) 2008-11-25 2012-02-21 (주)아모레퍼시픽 Hair cosmetic composition containing 6 years root Panax Ginseng water
KR20120080031A (en) * 2011-01-06 2012-07-16 (주)대덕바이오 Composition for enhancing hair growth containing saponin rd and re as active ingredients
KR20120112928A (en) * 2011-04-04 2012-10-12 충남대학교산학협력단 Injectable composition for enhancing hair growth containing saponin rg1 as active ingredient

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20170024915A (en) 2015-08-26 2017-03-08 영림영농조합법인 제주편백우드 Cosmetic composition for hair or scalp and preparation method thereof
KR20200011781A (en) 2018-07-25 2020-02-04 영남대학교 산학협력단 Cosmetic composition for improving the health of scalp comprising natural caffeine and chlorogenic acid
WO2020262933A1 (en) 2019-06-25 2020-12-30 충남대학교산학협력단 Pharmaceutical composition for preventing hair loss or promoting hair growth, comprising ginsenoside rg4 or mixture (rgx 365) of ginsenosides rg2, rg4, rg6, and rh1 as active ingredient
KR20210000425A (en) 2019-06-25 2021-01-05 아레즈 주식회사 A pharmaceutical composition comprising ginsenoside Rg4 or ginsenoside Rg2, Rg4, Rg6 and Rh1 mixture(Rgx 365) for preventing hair loss or stimulating hair growth
WO2024174889A1 (en) * 2023-02-23 2024-08-29 茵素科技(广州)有限公司 Ginsenoside composition, daily chemical, and use

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