CN112716844A

CN112716844A - Hand cream and preparation method thereof

Info

Publication number: CN112716844A
Application number: CN202110041273.0A
Authority: CN
Inventors: 刘念宁; 徐卫东; 聂开品; 方随换; 袁仲喜; 雷冬梅
Original assignee: Guizhou Dalong Pharmaceutical Co ltd
Current assignee: Guizhou Dalong Pharmaceutical Co ltd
Priority date: 2021-01-13
Filing date: 2021-01-13
Publication date: 2021-04-30
Anticipated expiration: 2041-01-13
Also published as: CN112716844B

Abstract

The invention relates to a hand cream and a preparation method thereof, wherein the hand cream comprises the following raw and auxiliary materials: chamomile water or chamomile extract, bisabolol, ethylhexyl stearate, glycerol, glyceryl stearate, palmitic acid, stearic acid, ubiquinone, phenoxyethanol, cetostearyl alcohol, cetyl palmitate, cocoglycerides, sodium stearyl glutamate, caprylyl glycol, polydimethylsiloxane, sodium polyacrylate, sodium hydroxide, lactic acid, potassium sorbate, sodium benzoate, essence and water. The hand cream has the beneficial effects of bacteriostasis, anti-inflammation, allergy relief, wrinkle resistance and repair, and has the advantages of easily obtained raw materials, low cost, simple preparation process and easy industrial production.

Description

Hand cream and preparation method thereof

Technical Field

The invention belongs to the technical field of cosmetic preparation, and particularly relates to hand cream and a preparation method thereof.

Background

With the rapid development of social economy, the working pressure, indoor and outdoor environmental pollution and radiation are more and more serious, so that various problems such as water shortage, sensitivity and the like easily occur to the skin of people. The hand is called as the second face of a person, the hands are in a continuous working process in daily life, harmful bacteria and substances are in contact with the hands, and the skin of the hands is more easily attacked by the bacteria and allergens due to frequent cleaning, so that the skin of the hands is rapidly aged. As is known, the most convenient method for caring hand skin is to apply hand cream.

The hand cream on the market at present is various in variety, and is divided according to functions, and roughly comprises four types, namely a moisturizing type hand cream, a repairing type hand cream, a protecting type hand cream and a cutin removing type hand cream, wherein the efficacy of the moisturizing type hand cream is not obvious, the components of the repairing type hand cream and the protecting type hand cream are relatively complex, and some hand creams are added with effective components such as rare Chinese medicinal materials, so that the cost is high, and the audience range is small; many products also contain harmful substances such as pigments, and the long-term use of the products can seriously affect the health of people. Therefore, the hand care and repair product which is safe and effective to develop, has the repair effects of bacteriostasis, anti-inflammation, allergy relief, anti-aging, wrinkle removal and the like, is safe and has no toxic or side effect has wide market prospect.

The prior art is Chinese invention patent: the invention discloses a nourishing and moistening type hand cream and a preparation method thereof (application number: 201410658015.7). The invention discloses a nourishing and moistening type hand cream and a preparation method thereof, wherein the hand cream contains the following substances: shea butter, horse oil, wheat germ oil, rose soaking oil, snow lotus soaking oil, forget-me-not soaking oil, universal self-emulsifying compound emulsifier AC-402, 25% triethanolamine, bletilla striata extracting solution, green tea extracting solution, kiwi fruit squeezing solution, pyracantha fortuneana fruit squeezing solution, 1, 2-propylene glycol, biological polysaccharide gum, 20% urea solution, liponic EG-1, trehalose, nicotinamide, honey, vitamin E, sodium alginate, hydroxypropyl methyl cellulose, 1% disodium ethylene diamine tetraacetate solution, 10% citric acid solution, 5% ethylparaben alcoholic solution, distilled water and essence. Compared with the prior art, the hand moisturizing and whitening cream brings rich nutrition to hand skin, can deeply moisten and repair dry and rough hands, regulates water and oil balance, softens old waste cutin, smoothes fine lines, replenishes water for the hands, and increases moisturizing and whitening effects.

The invention adopts 9 plant essential oils or extracts such as shea butter, wheat germ oil, rose soaking oil, snow lotus soaking oil, forget-me-not soaking oil, bletilla striata extract, green tea extract, kiwi fruit extract, pyracantha fortuneana fruit extract and the like, and has the advantages of more plant extracts, higher raw material cost, complex preparation process, undefined bacteriostatic and anti-inflammatory effects and the like.

Disclosure of Invention

In order to overcome the problems in the prior art, the invention provides a hand cream.

Meanwhile, the invention also provides a preparation method of the hand cream.

The invention is realized by the following technical scheme:

the invention relates to hand cream which is prepared from the following raw and auxiliary materials in parts by weight: 0.5-1.5% of chamomile water or chamomile extracting solution, 0.05-0.15% of bisabolol, 0.5-1.5% of ethylhexyl stearate, 3-7% of glycerol, 0.5-1.5% of glycerol stearate, 1-5% of palmitic acid, 2-6% of stearic acid, 0.03-0.12% of ubiquinone, 0.5-1.5% of phenoxyethanol, 0.5-1.5% of cetostearyl alcohol, 0.5-1.5% of cetyl palmitate, 0.5-1.5% of coco glyceride, 0.2-1.0% of sodium stearyl glutamate, 0.2-1.0% of caprylyl glycol, 0.4-1.0% of polydimethylsiloxane, 0.2-1.0% of sodium polyacrylate, 0.01-0.03% of sodium hydroxide, 0.004-0.01% of lactic acid, 0.001-0.004% of potassium sorbate, 0.001-0.004% of sodium benzoate, 0.05-0.12% of essence and the balance of water.

Preferably, the hand cream is prepared from the following raw and auxiliary materials in percentage by weight: 0.8-1.2 percent of chamomile water or chamomile extracting solution, 0.08-0.12 percent of bisabolol, 0.8-1.2 percent of ethylhexyl stearate, 4-6 percent of glycerol, 0.8-1.2 percent of glycerol stearate, 1-3 percent of palmitic acid, 3-5 percent of stearic acid, 0.05-0.1 percent of ubiquinone, 0.8-1.2 percent of phenoxyethanol, 0.8-1.2 percent of cetostearyl alcohol, 0.6-1.2 percent of cetyl palmitate, 0.8-1.2 percent of coco glyceride, 0.4-0.8 percent of sodium stearyl glutamate, 0.4-0.8 percent of octyl glycol, 0.6-0.8 percent of polydimethylsiloxane, 0.4-0.8 percent of sodium polyacrylate, 0.01-0.02 percent of sodium hydroxide, 0.005-0.008 percent of lactic acid, 0.002-0.003 percent of potassium sorbate, 0.002-0.003 percent of sodium benzoate, 0.06-0.1 percent of essence and the balance of water.

Further preferably, the hand cream is prepared from the following raw and auxiliary materials in percentage by weight: 0.99% of chamomile water or chamomile extract, 0.1% of bisabolol, 1% of ethylhexyl stearate, 5.0745% of glycerol, 1% of glyceryl stearate, 2.2% of palmitic acid, 3.8% of stearic acid, 0.05% of ubiquinone, 0.91% of phenoxyethanol, 0.9% of cetostearyl alcohol, 0.8% of cetyl palmitate, 0.8% of cocoglycerides, 0.5% of sodium stearyl glutamate, 0.45% of caprylyl glycol, 0.4% of polydimethylsiloxane, 0.35% of sodium polyacrylate, 0.01% of sodium hydroxide, 0.008% of lactic acid, 0.001% of potassium sorbate, 0.001% of sodium benzoate, 0.08% of essence and the balance of water.

The mother chrysanthemum extracting solution in the hand cream is prepared by the following steps: taking a mother chrysanthemum medicinal material, selecting impurities, cleaning, drying, crushing, sieving with a 60-mesh sieve, adding 10-15 times of 50-60% acetone aqueous solution, soaking at 35 ℃ for 1.5h, performing ultrasonic extraction at 40-60 ℃ for 2 times, performing 1-2 h each time, centrifuging the extracting solution at 3000r/min for 25min, and taking supernatant to obtain the mother chrysanthemum extracting solution.

Preferably, the chamomile extracting solution is prepared by the following steps: taking a mother chrysanthemum medicinal material, selecting impurities, cleaning, drying, crushing, sieving with a 60-mesh sieve, adding 12 times of 55% acetone aqueous solution, soaking at 35 ℃ for 1.5h, performing ultrasonic extraction at 50 ℃ for 2 times, each time for 1.5h, centrifuging the extracting solution at 3000r/min for 25min, and taking supernatant to obtain the mother chrysanthemum extracting solution.

The hand cream is prepared by respectively emulsifying the raw materials according to an oil phase and a water phase, or integrally mixing the raw materials.

Preferably, the method for preparing the hand cream comprises the following preparation steps:

1) weighing stearic acid, glyceryl stearate, cetostearyl alcohol, polydimethylsiloxane, ethylhexyl stearate, palmitic acid, cetyl palmitate, sodium polyacrylate, cocoglyceride and sodium stearyl glutamate according to the formula, sequentially adding into an oil phase pot, heating to 85 ℃, and stirring until the mixture is completely dissolved uniformly to obtain an oil phase mixture A;

2) adding water, glycerol, caprylyl glycol and lactic acid into a water phase pot in sequence according to the formula amount, heating to 90 ℃, and uniformly stirring to obtain a water phase mixture B;

3) pumping the water phase mixture B prepared in the step 2) into a vacuum emulsifying pot, stirring while slowly pumping the oil phase mixture A into the vacuum emulsifying pot, stirring at a stirring speed of 2000-4000 r/min for 10-20 min, homogenizing at a temperature of 75-85 ℃ for 15min, and vacuumizing to reduce the temperature to 50 ℃;

4) adding flos Matricariae Chamomillae water or flos Matricariae Chamomillae extract and bisabolol into emulsifying pot, stirring, and homogenizing for 10 min; sequentially adding ubiquinone, phenoxyethanol, potassium sorbate, sodium benzoate and essence according to the formula ratio, stirring and mixing, and homogenizing for 10 min;

5) and (3) vacuumizing the emulsifying pot, cooling to 40-50 ℃, adding sodium hydroxide, fully stirring, adjusting the pH value to 7.0 to form stable and uniform emulsion, and cooling to room temperature to obtain the emulsion.

Further preferably, the method for preparing the hand cream comprises the following preparation steps:

3) pumping the water phase mixture B prepared in the step 2) into a vacuum emulsifying pot, stirring while slowly pumping the oil phase mixture A into the vacuum emulsifying pot, stirring at the stirring speed of 3000r/min for 15min, homogenizing at the temperature of 80 ℃ for 15min, vacuumizing and cooling to 50 ℃;

5) and (3) vacuumizing the emulsifying pot, cooling to 45 ℃, adding sodium hydroxide with the formula amount, fully stirring, adjusting the pH value to 7.0 to form stable and uniform emulsion, and cooling to room temperature to obtain the emulsion.

Preferably, the method for preparing the hand cream comprises the steps of weighing chamomile water or chamomile extracting solution, bisabolol, ethylhexyl stearate, glycerol, glyceryl stearate, palmitic acid, stearic acid, ubiquinone, phenoxyethanol, cetostearyl alcohol, cetyl palmitate, cocoglyceride, sodium stearyl glutamate, caprylyl glycol, polydimethylsiloxane, sodium polyacrylate, sodium hydroxide, lactic acid, potassium sorbate, sodium benzoate, essence and water according to a formula, mixing, heating to 75-85 ℃, stirring at a stirring speed of 2000-3000 r/min for 10-20 min, and cooling to room temperature to obtain the hand cream.

Further preferably, the method for preparing the hand cream comprises the steps of weighing chamomile water or chamomile extract, bisabolol, ethylhexyl stearate, glycerol, glyceryl stearate, palmitic acid, stearic acid, ubiquinone, phenoxyethanol, cetostearyl alcohol, cetyl palmitate, cocoglycerides, sodium stearyl glutamate, caprylyl glycol, polydimethylsiloxane, sodium polyacrylate, sodium hydroxide, lactic acid, potassium sorbate, sodium benzoate, essence and water according to the formula, mixing, heating to 80 ℃, stirring at the stirring speed of 2000r/min for 10min, and cooling to room temperature to obtain the hand cream.

The invention has the advantages of

Through a large amount of formula screening experiments and efficacy verification experiments, the invention mainly has the following beneficial effects:

1. tests prove that the product of the invention has uniform and fine texture, stable property, easy storage, good spreadability, fresh aroma, mildness, no stimulation and good safety.

2. The hand cream prepared by the invention has obvious repair effects of bacteriostasis, inflammation diminishing, oxidation resistance, wrinkle resistance and the like.

3. The formula of the invention has the advantages of rich raw materials, easy acquisition, low cost and convenient popularization.

4. The preparation method of the hand cream provided by the invention is simple and feasible, and is suitable for industrial production.

5. The product of the invention has higher bacteriostatic rate on staphylococcus aureus, escherichia coli, candida albicans, bacillus cereus and trichophyton mentagrophytes than the comparative examples, which shows that the formula can be combined for use to obviously improve the bacteriostatic effect.

Detailed Description

The present invention is described in detail below with reference to specific embodiments, which will help those skilled in the art to further understand the present invention, but not limit the present invention in any way, and those skilled in the art can make various changes and modifications without departing from the spirit of the present invention, which falls into the protection scope of the present invention.

The chamomile water, stearic acid, glyceryl stearate, cetostearyl alcohol, polydimethylsiloxane, ethylhexyl stearate, palmitic acid, cetyl palmitate, sodium polyacrylate, cocoglycerides, sodium stearyl glutamate, bisabolol, glycerol, caprylyl glycol, lactic acid, ubiquinone, phenoxyethanol, potassium sorbate, sodium benzoate and sodium hydroxide in the formula are all commercially available products.

The essence of the formula is any one of natural plant essences such as commercially available chamomile essence, rose essence, lavender essence and the like.

The chamomile extracting solution with the formula is prepared according to the preparation method.

The water of the formula of the invention is any one of commercially available deionized water, distilled water or glacier water.

Example 1:

the components of the invention are as follows: 0.5% of chamomile water or chamomile extract, 0.05% of bisabolol, 0.5% of ethylhexyl stearate, 3% of glycerol, 0.5% of glyceryl stearate, 1% of palmitic acid, 2% of stearic acid, 0.03% of ubiquinone, 0.5% of phenoxyethanol, 0.5% of cetostearyl alcohol, 0.5% of cetyl palmitate, 0.5% of cocoglycerides, 0.2% of sodium stearyl glutamate, 0.2% of caprylyl glycol, 0.4% of polydimethylsiloxane, 0.2% of sodium polyacrylate, 0.01% of sodium hydroxide, 0.004% of lactic acid, 0.001% of potassium sorbate, 0.001% of sodium benzoate, 0.05% of essence, and the balance of water.

The invention is prepared according to any one of the following eight preparation methods.

The preparation method comprises the following steps:

the chamomile flower water prepared by a professional manufacturer is purchased on the market.

1) Weighing stearic acid, glyceryl stearate, cetearyl alcohol, polydimethylsiloxane, ethylhexyl stearate, palmitic acid, cetyl palmitate, sodium polyacrylate, cocoglycerides and sodium stearyl glutamate according to the formula of the embodiment, sequentially adding the stearic acid, the glyceryl stearate, the cetearyl alcohol, the polydimethylsiloxane, the ethylhexyl stearate, the palmitic acid, the cetyl palmitate and the sodium stearate into an oil phase pot, heating to 85 ℃, and stirring until the mixture is completely dissolved uniformly to obtain an oil phase mixture A;

2) adding water, glycerol, caprylyl glycol and lactic acid into a water phase pot in sequence according to the formula amount of the embodiment, heating to 90 ℃, and uniformly stirring to obtain a water phase mixture B;

3) pumping the water phase mixture B prepared in the step 2) into a vacuum emulsifying pot, stirring while slowly pumping the oil phase mixture A into the vacuum emulsifying pot, stirring at a stirring speed of 2000r/min for 10min, homogenizing at a temperature of 75 ℃ for 15min, vacuumizing and cooling to 50 ℃;

4) adding flos Matricariae Chamomillae water and bisabolol into emulsifying pot, stirring, and homogenizing for 10 min; sequentially adding ubiquinone, phenoxyethanol, potassium sorbate, sodium benzoate and essence according to the formula ratio, stirring and mixing, and homogenizing for 10 min;

5) and (3) vacuumizing the emulsifying pot, cooling to 40 ℃, adding sodium hydroxide with the formula amount, fully stirring, adjusting the pH value to 7.0 to form stable and uniform emulsion, and cooling to room temperature to obtain the emulsion.

The preparation method (II):

The preparation method comprises the following steps:

3) pumping the water phase mixture B prepared in the step 2) into a vacuum emulsifying pot, stirring while slowly pumping the oil phase mixture A into the vacuum emulsifying pot, stirring at the stirring speed of 4000r/min for 20min, homogenizing at the temperature of 85 ℃ for 15min, vacuumizing and cooling to 50 ℃;

5) and (3) vacuumizing the emulsifying pot, cooling to 50 ℃, adding sodium hydroxide with the formula amount, fully stirring, adjusting the pH value to 7.0 to form stable and uniform emulsion, and cooling to room temperature to obtain the emulsion.

The preparation method (IV):

1) the chamomile flower water prepared by a professional manufacturer is purchased on the market.

2) Taking chamomile water, bisabolol, ethylhexyl stearate, glycerol, glyceryl stearate, palmitic acid, stearic acid, ubiquinone, phenoxyethanol, cetostearyl alcohol, cetyl palmitate, cocoglyceride, sodium stearyl glutamate, octyl glycol, polydimethylsiloxane, sodium polyacrylate, sodium hydroxide, lactic acid, potassium sorbate, sodium benzoate, essence and water according to the formula amount, mixing, heating to 80 ℃, stirring at the stirring speed of 2000r/min for 10min, and cooling to room temperature to obtain the product.

The preparation method comprises the following steps:

1) preparing a mother chrysanthemum extracting solution: selecting flos Matricariae Chamomillae as medicinal material, selecting impurities, cleaning, oven drying, pulverizing, sieving with 60 mesh sieve, adding 10 times of 50% acetone water solution, soaking at 35 deg.C for 1.5h, performing ultrasonic extraction at 40 deg.C for 2 times, each time for 2h, centrifuging the extractive solution at 3000r/min for 25min, and collecting supernatant to obtain flos Matricariae Chamomillae extractive solution;

2) weighing stearic acid, glyceryl stearate, cetearyl alcohol, polydimethylsiloxane, ethylhexyl stearate, palmitic acid, cetyl palmitate, sodium polyacrylate, cocoglycerides and sodium stearyl glutamate according to the formula of the embodiment, sequentially adding the stearic acid, the glyceryl stearate, the cetearyl alcohol, the polydimethylsiloxane, the ethylhexyl stearate, the palmitic acid, the cetyl palmitate and the sodium stearate into an oil phase pot, heating to 85 ℃, and stirring until the mixture is completely dissolved uniformly to obtain an oil phase mixture A;

3) adding water, glycerol, caprylyl glycol and lactic acid into a water phase pot in sequence according to the formula amount of the embodiment, heating to 90 ℃, and uniformly stirring to obtain a water phase mixture B;

4) pumping the water phase mixture B prepared in the step 3) into a vacuum emulsifying pot, stirring while slowly pumping the oil phase mixture A into the vacuum emulsifying pot, stirring at a stirring speed of 2000r/min for 10min, homogenizing at a temperature of 75 ℃ for 15min, vacuumizing and cooling to 50 ℃;

5) adding the chamomile extracting solution prepared in the step 1) and bisabolol into an emulsifying pot, uniformly stirring, and homogenizing for 10 min; sequentially adding ubiquinone, phenoxyethanol, potassium sorbate, sodium benzoate and essence according to the formula ratio, stirring and mixing, and homogenizing for 10 min;

6) and (3) vacuumizing the emulsifying pot, cooling to 40 ℃, adding sodium hydroxide with the formula amount, fully stirring, adjusting the pH value to 7.0 to form stable and uniform emulsion, and cooling to room temperature to obtain the emulsion.

The preparation method comprises the following steps:

1) preparing a mother chrysanthemum extracting solution: selecting flos Matricariae Chamomillae as medicinal material, selecting impurities, cleaning, oven drying, pulverizing, sieving with 60 mesh sieve, adding 12 times of 55% acetone aqueous solution, soaking at 35 deg.C for 1.5h, performing ultrasonic extraction at 50 deg.C for 2 times, each time for 1.5h, centrifuging the extractive solution at 3000r/min for 25min, and collecting supernatant to obtain flos Matricariae Chamomillae extractive solution;

2) weighing stearic acid, glyceryl stearate, cetostearyl alcohol, polydimethylsiloxane, ethylhexyl stearate, palmitic acid, cetyl palmitate, sodium polyacrylate, cocoglyceride and sodium stearyl glutamate according to the formula, sequentially adding into an oil phase pot, heating to 85 ℃, and stirring until the mixture is completely dissolved uniformly to obtain an oil phase mixture A;

3) adding water, glycerol, caprylyl glycol and lactic acid into a water phase pot in sequence according to the formula amount, heating to 90 ℃, and uniformly stirring to obtain a water phase mixture B;

4) pumping the water phase mixture B prepared in the step 3) into a vacuum emulsifying pot, stirring while slowly pumping the oil phase mixture A into the vacuum emulsifying pot, stirring at the stirring speed of 3000r/min for 15min, homogenizing at the temperature of 80 ℃ for 15min, vacuumizing and cooling to 50 ℃;

6) vacuumizing an emulsifying pot, cooling to 45 ℃, adding sodium hydroxide with the formula amount, fully stirring, adjusting the pH value to 7.0 to form stable and uniform emulsion, and cooling to room temperature to obtain the emulsion.

The preparation method comprises the following steps:

1) preparing a mother chrysanthemum extracting solution: taking a mother chrysanthemum medicinal material, selecting impurities, cleaning, drying, crushing, sieving with a 60-mesh sieve, adding 15 times of 60% acetone aqueous solution, soaking at 35 ℃ for 1.5h, performing ultrasonic extraction at 60 ℃ for 2 times, each time for 1h, centrifuging the extracting solution at 3000r/min for 25min, and taking supernatant to obtain a mother chrysanthemum extracting solution;

4) pumping the water phase mixture B prepared in the step 3) into a vacuum emulsifying pot, stirring while slowly pumping the oil phase mixture A into the vacuum emulsifying pot, stirring at the stirring speed of 4000r/min for 20min, homogenizing at the temperature of 85 ℃ for 15min, vacuumizing and cooling to 50 ℃;

6) and (3) vacuumizing the emulsifying pot, cooling to 50 ℃, adding sodium hydroxide with the formula amount, fully stirring, adjusting the pH value to 7.0 to form stable and uniform emulsion, and cooling to room temperature to obtain the emulsion.

The preparation method comprises the following steps:

2) weighing the chamomile flower extract prepared in the step 1), bisabolol, ethylhexyl stearate, glycerol, glyceryl stearate, palmitic acid, stearic acid, ubiquinone, phenoxyethanol, cetearyl alcohol, cetyl palmitate, cocoglyceride, sodium stearyl glutamate, octyl glycol, polydimethylsiloxane, sodium polyacrylate, sodium hydroxide, lactic acid, potassium sorbate, sodium benzoate, essence and water according to a formula, mixing, heating to 80 ℃, stirring at a stirring speed of 2000r/min for 10min, and cooling to room temperature to obtain the chrysanthemum flower extract.

Example 2:

the components of the invention are as follows: 1.5% of chamomile water or chamomile extract, 0.15% of bisabolol, 1.5% of ethylhexyl stearate, 7% of glycerol, 1.5% of glyceryl stearate, 5% of palmitic acid, 6% of stearic acid, 0.12% of ubiquinone, 1.5% of phenoxyethanol, 1.5% of cetostearyl alcohol, 1.5% of cetyl palmitate, 1.5% of coco glyceride, 1.0% of sodium stearyl glutamate, 1.0% of caprylyl glycol, 1.0% of polydimethylsiloxane, 1.0% of sodium polyacrylate, 0.03% of sodium hydroxide, 0.01% of lactic acid, 0.004% of potassium sorbate, 0.004% of sodium benzoate, 0.12% of essence and the balance of water.

The production methods of the present invention adopted the production methods (one) to (eight) in example 1.

Example 3:

the components of the invention are as follows: 0.8% of chamomile water or chamomile extract, 0.08% of bisabolol, 0.8% of ethylhexyl stearate, 4% of glycerol, 0.8% of glyceryl stearate, 1% of palmitic acid, 3% of stearic acid, 0.05% of ubiquinone, 0.8% of phenoxyethanol, 0.8% of cetostearyl alcohol, 0.6% of cetyl palmitate, 0.8% of cocoglycerides, 0.4% of sodium stearyl glutamate, 0.4% of caprylyl glycol, 0.6% of polydimethylsiloxane, 0.4% of sodium polyacrylate, 0.01% of sodium hydroxide, 0.005% of lactic acid, 0.002% of potassium sorbate, 0.002% of sodium benzoate, 0.06% of essence, and the balance of water.

Example 4:

the components of the invention are as follows: 1.2% of chamomile water or chamomile extract, 0.12% of bisabolol, 1.2% of ethylhexyl stearate, 6% of glycerol, 1.2% of glyceryl stearate, 3% of palmitic acid, 5% of stearic acid, 0.06% of ubiquinone, 1.2% of phenoxyethanol, 1.2% of cetostearyl alcohol, 1.2% of cetyl palmitate, 1.2% of coco glyceride, 0.8% of sodium stearyl glutamate, 0.8% of caprylyl glycol, 0.8% of polydimethylsiloxane, 0.8% of sodium polyacrylate, 0.02% of sodium hydroxide, 0.008% of lactic acid, 0.003% of potassium sorbate, 0.003% of sodium benzoate, 0.1% of essence, and the balance of water.

Example 5:

the components of the invention are as follows: 0.99% of chamomile water or chamomile extract, 0.1% of bisabolol, 1% of ethylhexyl stearate, 5.0745% of glycerol, 1% of glyceryl stearate, 2.2% of palmitic acid, 3.8% of stearic acid, 0.05% of ubiquinone, 0.91% of phenoxyethanol, 0.9% of cetostearyl alcohol, 0.8% of cetyl palmitate, 0.8% of cocoglycerides, 0.5% of sodium stearyl glutamate, 0.45% of caprylyl glycol, 0.4% of polydimethylsiloxane, 0.35% of sodium polyacrylate, 0.01% of sodium hydroxide, 0.008% of lactic acid, 0.001% of potassium sorbate, 0.001% of sodium benzoate, 0.08% of essence and the balance of water.

In order to further illustrate the components and effects of the present invention, the inventors conducted a lot of experimental studies on the screening of the components of the raw materials and the preparation process, and extract part of the experimental data as follows:

one, component source and action

The chamomile extracting solution is derived from chamomile, namely German chamomile, and is one of 5 best-selling herbaceous plants in the world. The flos Matricariae Chamomillae is a 1-year-old herbaceous plant, and the flos Matricariae Chamomillae extract mainly contains various chemical components such as coumarin, total flavone and volatile oil. The existing research shows that the active ingredients of the chamomile have various pharmacological effects of inhibiting fungi, diminishing inflammation, resisting oxidation and the like, have obvious inhibiting effects on staphylococcus aureus and escherichia coli, are very suitable for preparing skin care products, and have the effects of soothing allergy, repairing sensitive skin, reducing fine red blood streak, adjusting uneven skin color and the like.

Although the chamomile extract has better effects of sterilizing, diminishing inflammation, relieving, moisturizing and the like, in order to avoid the situation of content difference of effective components of the extract and realize better action effect, the invention adds the bisabolol component.

The bisabolol is extracted from chrysanthemum plants, and has excellent pharmacological medicinal values of resisting infection and diminishing inflammation, relieving pain and swelling, promoting wound repair, inhibiting bacteria and relieving itching, accelerating ulcer healing, promoting cell regeneration, skin basal metabolism and the like. The bisabolol has good compatibility with skin, can effectively reduce skin inflammation, relieve skin acne, prevent acne, improve skin anti-irritation capability, repair skin with inflammation injury, and improve SPF value in sunscreen product. The bisabolol has obvious anti-inflammatory and antispasmodic effects, and on the function, the natural bisabolol has twice of the effects of a synthetic product, has the functions of relieving pain, alleviating irritation and resisting allergy, and has skin care effect on allergic skin or children skin.

The bisabolol has high permeability on the skin cortex, and the action of the bisabolol is dozens of times of that of a common penetrant; can be used as main agent or adjuvant for preventing and treating skin diseases such as acne, and also has skin conditioning effect. The bisabolol has the stability and good skin compatibility, is very suitable for being used in cosmetics, does not discolor after being stored for a long time, does not seep out of a plastic container, has the anti-inflammatory performance and also has the antibacterial activity, and has the remarkable inhibiting effect on staphylococcus aureus, bacillus cereus, escherichia coli, candida albicans, trichophyton mentagrophytes and trichophyton rubrum.

Bisabolol is mainly used in skin protection and skin care cosmetics as an active ingredient for protecting and caring for allergic skin, and is also suitable for use in sunscreen products, after-sunburn bath solutions, infant products and after-shave care products, and in oral hygiene products such as toothpaste and mouthwash. Has excellent assistant effects on skin itch, bacteriostasis, itch relief, sunburn repair, skin trauma recovery and the like, improves the anti-irritation working capacity of the skin, and repairs the skin with inflammation and negative injury.

Through tests, the inventor finds that the prepared hand cream has an obvious antioxidant effect, is easier to absorb by skin, is healthy and safe, and has no toxic or side effect when the chamomile extracting solution and the bisabolol are matched for use.

Through a large number of experiments, ubiquinone, namely coenzyme Q10, is added into the components, can penetrate into skin cells, accelerate cell metabolism, activate compact binding force among cells, form a colloidal network structure on the epidermis, and has obvious antioxidant effect.

Second, screening of formula and preparation process

One) screening basis

The optimal formula and process condition of the hand cream are screened and determined by adopting a comprehensive grading method and the standard QB/T1857-2013 of the skin-moistening cream. The comprehensive evaluation method adopts the following 4 indexes for evaluation:

the specific scoring value of each index is determined by the assessment method of the appearance character, the centrifugal stability, the heat resistance, the cold resistance and the viscosity of the paste. Wherein the appearance of the paste accounts for 30%, the paste is fine, bubble-free and precipitate-free, the cream with milk white color has high score, the centrifugal stability of the paste accounts for 20%, the difference of the centrifugal stability is measured by the height of oil-water layering, and the smaller the layering height value is, the higher the stability is. The paste has heat resistance and cold resistance of 30%, better performance, close to the state before standing, no precipitate and higher score. The viscosity of the paste was 20%, the closer the viscosity value to the reference, the higher the score. Specific scoring indices are shown in tables 1-2 below:

table 1 comprehensive performance evaluation chart of hand cream

TABLE 2 sensory and physicochemical indices of hand cream

II) screening of hand cream formula

According to the formula of related products, the approximate dosage range of each raw material is determined, the appropriate dosage range of each component is determined through a single-factor experiment, and finally the optimal formula of the hand cream is determined through orthogonal experiments and result analysis.

1. Single factor experiment

A large number of single-factor experiments in the early stage show that the addition of the glycerin affects the appearance and the stability of the ointment, and as the glycerin is used as a water phase, the addition affects the proportion of the water phase, the glycerin has strong hygroscopicity and absorbs moisture from the air, so that the skin moisturizing effect is realized.

Stearic acid and glyceryl stearate are used as an emulsifier, have a large influence on the performance of the paste, mainly influence the appearance of the paste, are added in too small amount, and are not fully emulsified and have low viscosity; the paste becomes uneven and not fine when the addition amount is too much.

Palmitic acid is used as a thickening agent, can effectively increase the viscosity of the paste and influence the stability of the paste, and the paste is unstable due to too small addition amount; the paste has increased viscosity and hardness due to excessive addition.

Cetearyl alcohol has the effects of inhibiting greasy feeling, reducing viscosity of wax raw materials, and stabilizing cosmetic emulsion.

The polydimethylsiloxane mainly influences the color and the smearing effect of the paste, and the color of the paste becomes dark due to excessive addition; the addition amount is too small, and the whitening phenomenon is easy to occur.

By referring to the formula and the ingredient dosage of the related hand cream and combining a large number of preliminary selection experimental results, the basic formula of the hand cream is preliminarily determined as follows: 0.5-1.5% of chamomile water or chamomile extracting solution, 0.05-0.15% of bisabolol, 0.5-1.5% of ethylhexyl stearate, 3-7% of glycerol, 0.5-1.5% of glycerol stearate, 2-5% of palmitic acid, 2-6% of stearic acid, 0.03-0.12% of ubiquinone, 0.5-1.5% of phenoxyethanol, 0.5-1.5% of cetostearyl alcohol, 0.5-1.5% of cetyl palmitate, 0.5-1.5% of coco glyceride, 0.2-1.0% of sodium stearyl glutamate, 0.2-1.0% of caprylyl glycol, 0.4-1.0% of polydimethylsiloxane, 0.2-1.0% of sodium polyacrylate, 0.01-0.03% of sodium hydroxide, 0.004-0.01% of lactic acid, 0.001-0.004% of potassium sorbate, 0.001-0.004% of sodium benzoate, 0.05-0.12% of essence and the balance of water.

2. Quadrature test

Because the influence of the glycerol, the stearic acid, the glyceryl stearate, the palmitic acid, the cetearyl alcohol, the polydimethylsiloxane and the chamomile extracting solution on the cream is large, the 7 factors are set by comprehensively considering different influences on the properties of the hand cream, each factor takes 3 levels, and an orthogonal experiment is carried out by adopting an L18-3-7 orthogonal table, which is shown in Table 3.

Table 3 horizontal table of component factors of hand cream

The following formulation combinations were initially selected by the orthogonal design principle, see table 4.

Table 4 hand cream formula table

And (3) evaluating the hand cream paste obtained by the 18 formulas by adopting a comprehensive grading method. The phenomena of the orthogonality experiment and the results of the orthogonality experiment were obtained and are shown in tables 5-7.

TABLE 5 orthogonal experimental phenomenon table of formulation

Table 6 results of formulation orthogonal experiments

TABLE 7 analysis of the formulation variance (. multidot.P.ltoreq.0.05)

As can be seen from the above table, the 18 samples obtained were tested according to the light industry standard, and according to the comprehensive scoring method, the cream quality of sample No. 2 was the best, and thus the factors affecting the cream of the hand cream were: c > E > D > F > B > A > G.

Therefore, the optimal formulation for the hand cream is shown in table 8 below.

Table 8 optimal formulation for hand cream

Thirdly) screening of hand cream preparation process

The performance of the hand cream is influenced by the raw materials, and the emulsifying temperature, the emulsifying time, the stirring speed and the feeding mode in the preparation process have larger influence on the appearance performance of the cream

Under the optimal hand cream formula condition, a large number of single-factor experimental results show that:

the emulsifying temperature mainly influences the appearance of the paste, and when the temperature is too low, the paste cannot be completely emulsified, and oil and water separation substances appear.

The emulsifying time influences the appearance and heat resistance of the paste, and the paste has poor heat resistance and low viscosity when the emulsifying time is too short; the time is too long, a large amount of water is analyzed out due to heat resistance, and the delamination is easy.

The addition mode has great influence on the properties of the paste, wherein in the post-emulsifier method, before the emulsifier is added, other base materials are in a coarse dispersion system due to heating and stirring, and after the emulsifier is added, the base materials are further emulsified and dispersed to achieve an ideal emulsification effect; the mixing and heating method starts emulsification in the heating process, and the operation is simple and convenient; in the oil-water phase separation method, fine particle components are precipitated due to slight temperature differences.

The stirring speed is too high, a large amount of bubbles can be brought in, and the paste is not uniform; the stirring speed is too slow, the emulsification is incomplete, and the stability of the paste is affected.

Under the condition of the optimal formula, four process parameters of emulsification time, emulsification temperature, stirring speed and feeding mode are selected as investigation factors, and the orthogonal experimental results of the process parameters are obtained by a comprehensive grading method and are shown in tables 9-12.

Table 9 process factor water leveling

TABLE 10 table of process orthogonality experiment

TABLE 11 analysis table of process orthogonal experiment results

TABLE 12 Process analysis of variance ([ P ] 0.05)

As can be seen from the data in tables 10-11, the emulsifying mode has the greatest influence on the quality of the hand cream, and secondly, the emulsifying temperature is determined, the factors such as energy consumption and the like are comprehensively considered, and the optimal process conditions are determined as follows: A1B2C1D2 is prepared by mixing and heating at 80 deg.C under stirring speed of 2000r/min for emulsifying for 10 min.

As can be seen from the data in table 12, examination of the results with F showed that factor D was significantly different from the results. In the four-factor three-level orthogonal experiment, since L9-3-4 was selected without empty columns, a factor having a small influence factor was selected as an error term. Namely, factor a (one of the least squares of deviation) is selected as the error term. According to the test results, the optimal test conditions A1B2C1D2 are verified, and the results of repeated tests show that the process is stable and has good reproducibility.

Third, verification test

In order to further illustrate the beneficial effects of the invention, the inventor optimizes the optimal base formula of the obtained hand cream and the optimal preparation process according to the above tests, and the inventor carries out a series of verification experiments and provides the following test data:

one) experimental sample and method

1. Experimental sample

The products prepared in examples 1-5 of the invention are 5 groups, comparative example 1 (chamomile extract), comparative example 2 (commercially available chamomile flower water), and comparative example 3 (bisabolol).

2. Sample preparation method

Preparation methods of examples 1 to 5 of the present invention the product obtained by the preparation method (v) of example 1 of the present invention.

3. Comparative example 1 production method

According to the preparation method of the invention in the embodiment 1, the preparation method of the chamomile extract comprises the following steps: selecting flos Matricariae Chamomillae as medicinal material, selecting impurities, cleaning, oven drying, pulverizing, sieving with 60 mesh sieve, adding 12 times of 55% acetone aqueous solution, soaking at 35 deg.C for 1.5h, performing ultrasonic extraction at 50 deg.C for 2 times, each time for 1.5h, centrifuging the extractive solution at 3000r/min for 25min, and collecting supernatant.

4. Comparative example 2 preparation method: commercially available chamomile flower water was purchased.

5. Comparative example 3 preparation method: commercially available bisabolol was purchased.

II) physicochemical indexes of the invention

1) Properties of the present invention

The hand cream prepared in the embodiments 1 to 5 of the invention is uniform milky white, fresh and fine in texture, good in spreadability and fresh in fragrance.

2) pH value of the invention

The hand cream prepared in the embodiments 1 to 5 of the invention has a pH value of 6.0 to 7.0 measured by a pH meter.

Three) stability test

The hand creams prepared in the embodiments 1 to 5 of the invention are respectively placed in glass bottles and kept standing for 12 months at room temperature, and no obvious layering phenomenon and no change in smell occur.

The hand cream prepared in the embodiments 1 to 5 of the invention is packaged in a glass bottle and is refrigerated in a refrigerator at the temperature of 2 to 5 ℃ for 1 month without obvious layering phenomenon. The hand cream is placed in a thermostat with the temperature of 55 ℃ for 24 hours, and the hand cream has no layering phenomenon.

The hand cream prepared by the invention is packaged in a closed test tube, and is centrifuged at 3500r/min for 30min without obvious layering.

IV) bacteriostatic test

The products prepared in the examples 1-5 are respectively prepared into water solutions with the same concentration in 5 groups, the comparative example 1, the comparative example 2 and the comparative example 3, and an in vitro bacteriostasis test is carried out, wherein the bacteriostasis results of 8 groups of test samples are shown in the following table 13. 0.5/1.5/0.8/1.2/1.0

TABLE 13 bacteriostatic results (%) of test samples

As can be seen from Table 13, the bacteriostatic rates of the products prepared in the embodiments 1-5 of the invention on Staphylococcus aureus, Escherichia coli, Candida albicans, Bacillus cereus and Trichophyton mentagrophytes are all higher than those of the products prepared in the comparative examples 1-3, which shows that the bacteriostatic effect can be significantly improved by the combined use of the formula of the invention.

Five) animal allergy test

1. And (3) testing a sample: the products prepared in the embodiments 1-5 of the invention.

2. Grouping: the skin health of the experimental mice total 60, set up the experimental group 5 groups, blank control group 1 group, each group 10.

3. The test method comprises the following steps: a proper amount of the hand cream prepared in the invention in the examples 1-5 is respectively applied to the left hind limb of the white mouse every day, and the application and observation are continuously carried out for 7 days.

4. And (3) test results: the mice in the experimental group and the blank control group have no allergic reaction such as red swelling.

Six) human safety test

2. Grouping: selected 50 healthy subjects 18-60 years of age, without a history of skin allergy, and subjects not participating in any skin test within 3 months, were randomized into 5 groups of 10 persons each.

3. The test method comprises the following steps: the area of the back of the hand of each subject, 3 x 3cm2, was used as the test site, and was kept dry and protected from other external preparations; the product prepared in the embodiment 1-5 of the invention is uniformly smeared on a tested part every day for 7 days continuously, the skin reaction judgment standard is referred to in the open patch test and detailed in the following table 14, and the skin reaction is observed at the same time.

4. And (3) test results: the results of the tests are detailed in Table 15 below.

TABLE 14 open Patch test skin response criteria

And (3) test results: if 1-grade skin adverse reaction is more than or equal to 8, 2-grade skin adverse reaction is more than or equal to 3, or any 3-grade or more than 3-grade skin adverse reaction is more than or equal to 1 in 50 subjects, the test object is judged to have obvious adverse reaction on the human body.

TABLE 15 results of human safety tests

As can be seen from the table 15, the hand cream prepared in the embodiments 1 to 5 of the present invention has no 1 adverse reaction, which indicates that the present invention has reliable safety and low sensitivity.

Seven) wrinkle repair test

1. And (3) testing a sample:

the products prepared in the embodiments 1-5 of the invention.

2. Grouping:

60 healthy female subjects with mild wrinkles on hand skins of 30-45 years old are selected, the subjects do not participate in any skin test within 3 months, and the subjects are randomly divided into 6 groups, wherein the 5 groups of the experimental group and the 1 group of the blank control group are 10 persons in each group.

3. The test method comprises the following steps:

respectively dispensing the products prepared in the embodiments 1-5 of the invention to test subjects in an experimental group, wherein the usage amount is 1 month each time, and the products are continuously dispensed for 6 months, and all the test subjects in the experimental group apply the products 3 times in the morning, the noon and the evening each day, and can not apply any other products in the experimental stage; blank control, without any product applied, was followed monthly to record skin changes.

4. And (3) test results:

the skin wrinkles on the hands of the subjects who used the products prepared in examples 1 to 5 of the present invention were significantly reduced after 6 months. The test results are shown in Table 16 below (note: + indicates the degree of wrinkles).

TABLE 16 wrinkle repair results of subjects

Through the above-mentioned several groups of physicochemical and functional experiments, the invention has the following beneficial effects: 1. the product of the invention has fresh and fine texture, good spreadability and fresh fragrance; 2. the product of the invention has stable property and is easy to store; 3. the product of the invention has good bacteriostatic action on staphylococcus aureus, escherichia coli, candida albicans, bacillus cereus, trichophyton mentagrophytes and other bacteria which are common in daily life; 4. animal and human body safety tests show that the product is mild, free of stimulation and high in safety; 5. the product of the invention has obvious anti-wrinkle repairing effect; 6. the preparation method of the product is simple, has low energy consumption and is suitable for industrial production.

While the invention has been described in detail in the foregoing by way of general description, specific embodiments and experiments, it will be apparent to those skilled in the art that certain changes and modifications may be made therein based on the invention. Accordingly, such modifications and improvements are intended to be within the scope of the invention as claimed.

Claims

1. The hand cream is characterized by being prepared from the following raw and auxiliary materials in parts by weight: 0.5-1.5% of chamomile water or chamomile extracting solution, 0.05-0.15% of bisabolol, 0.5-1.5% of ethylhexyl stearate, 3-7% of glycerol, 0.5-1.5% of glycerol stearate, 1-5% of palmitic acid, 2-6% of stearic acid, 0.03-0.12% of ubiquinone, 0.5-1.5% of phenoxyethanol, 0.5-1.5% of cetostearyl alcohol, 0.5-1.5% of cetyl palmitate, 0.5-1.5% of coco glyceride, 0.2-1.0% of sodium stearyl glutamate, 0.2-1.0% of caprylyl glycol, 0.4-1.0% of polydimethylsiloxane, 0.2-1.0% of sodium polyacrylate, 0.01-0.03% of sodium hydroxide, 0.004-0.01% of lactic acid, 0.001-0.004% of potassium sorbate, 0.001-0.004% of sodium benzoate, 0.05-0.12% of essence and the balance of water.

2. The hand cream as claimed in claim 1, which is prepared from the following raw and auxiliary materials in percentage by weight: 0.8-1.2 percent of chamomile water or chamomile extracting solution, 0.08-0.12 percent of bisabolol, 0.8-1.2 percent of ethylhexyl stearate, 4-6 percent of glycerol, 0.8-1.2 percent of glycerol stearate, 1-3 percent of palmitic acid, 3-5 percent of stearic acid, 0.05-0.1 percent of ubiquinone, 0.8-1.2 percent of phenoxyethanol, 0.8-1.2 percent of cetostearyl alcohol, 0.6-1.2 percent of cetyl palmitate, 0.8-1.2 percent of coco glyceride, 0.4-0.8 percent of sodium stearyl glutamate, 0.4-0.8 percent of octyl glycol, 0.6-0.8 percent of polydimethylsiloxane, 0.4-0.8 percent of sodium polyacrylate, 0.01-0.02 percent of sodium hydroxide, 0.005-0.008 percent of lactic acid, 0.002-0.003 percent of potassium sorbate, 0.002-0.003 percent of sodium benzoate, 0.06-0.1 percent of essence and the balance of water.

3. The hand cream as claimed in claim 1, which is prepared from the following raw and auxiliary materials in percentage by weight: 0.99% of chamomile water or chamomile extract, 0.1% of bisabolol, 1% of ethylhexyl stearate, 5.0745% of glycerol, 1% of glyceryl stearate, 2.2% of palmitic acid, 3.8% of stearic acid, 0.05% of ubiquinone, 0.91% of phenoxyethanol, 0.9% of cetostearyl alcohol, 0.8% of cetyl palmitate, 0.8% of cocoglycerides, 0.5% of sodium stearyl glutamate, 0.45% of caprylyl glycol, 0.4% of polydimethylsiloxane, 0.35% of sodium polyacrylate, 0.01% of sodium hydroxide, 0.008% of lactic acid, 0.001% of potassium sorbate, 0.001% of sodium benzoate, 0.08% of essence and the balance of water.

4. The hand cream as claimed in any one of claims 1 to 3, wherein the chamomile extract is prepared by the following steps: taking a mother chrysanthemum medicinal material, selecting impurities, cleaning, drying, crushing, sieving with a 60-mesh sieve, adding 10-15 times of 50-60% acetone aqueous solution, soaking at 35 ℃ for 1.5h, performing ultrasonic extraction at 40-60 ℃ for 2 times, performing 1-2 h each time, centrifuging the extracting solution at 3000r/min for 25min, and taking supernatant to obtain the mother chrysanthemum extracting solution.

5. The hand cream as claimed in claim 4, wherein the chamomile extract is prepared by the following steps: taking a mother chrysanthemum medicinal material, selecting impurities, cleaning, drying, crushing, sieving with a 60-mesh sieve, adding 12 times of 55% acetone aqueous solution, soaking at 35 ℃ for 1.5h, performing ultrasonic extraction at 50 ℃ for 2 times, each time for 1.5h, centrifuging the extracting solution at 3000r/min for 25min, and taking supernatant to obtain the mother chrysanthemum extracting solution.

6. A method for preparing the hand cream according to any one of claims 1 to 3, characterized in that the raw materials are prepared by emulsifying an oil phase and a water phase respectively, or mixing the raw materials integrally.

7. The process for preparing a hand cream according to claim 6, comprising the following preparation steps:

5) and (3) vacuumizing the emulsifying pot, cooling to 40-50 ℃, adding sodium hydroxide in a formula amount, fully stirring, adjusting the pH value to 7.0 to form stable and uniform emulsion, and cooling to room temperature to obtain the emulsion.

8. The process for preparing a hand cream according to claim 7, comprising the following preparation steps:

9. The method for preparing the hand cream according to claim 6, wherein the hand cream is prepared by taking chamomile water or chamomile extract, bisabolol, ethylhexyl stearate, glycerol, glyceryl stearate, palmitic acid, stearic acid, ubiquinone, phenoxyethanol, cetostearyl alcohol, cetyl palmitate, cocoglyceride, sodium stearyl glutamate, caprylyl glycol, polydimethylsiloxane, sodium polyacrylate, sodium hydroxide, lactic acid, potassium sorbate, sodium benzoate, essence and water according to a formula, mixing, heating to 75-85 ℃, stirring at a stirring speed of 2000-3000 r/min for 10-20 min, and cooling to room temperature.

10. The method for preparing hand cream according to claim 9, wherein chamomile water or chamomile extract, bisabolol, ethylhexyl stearate, glycerin, glyceryl stearate, palmitic acid, stearic acid, ubiquinone, phenoxyethanol, cetostearyl alcohol, cetyl palmitate, cocoglycerides, sodium stearyl glutamate, caprylyl glycol, polydimethylsiloxane, sodium polyacrylate, sodium hydroxide, lactic acid, potassium sorbate, sodium benzoate, essence, and water are measured according to a formula, mixed, heated to 80 ℃, stirred at a stirring speed of 2000r/min for 10min, and cooled to room temperature, and the hand cream is obtained.