CN112245314A - Lipstick containing tetrahydropyrimidine and preparation method thereof - Google Patents

Lipstick containing tetrahydropyrimidine and preparation method thereof Download PDF

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Publication number
CN112245314A
CN112245314A CN202011047282.2A CN202011047282A CN112245314A CN 112245314 A CN112245314 A CN 112245314A CN 202011047282 A CN202011047282 A CN 202011047282A CN 112245314 A CN112245314 A CN 112245314A
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oil
parts
tetrahydropyrimidine
wax
lip balm
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Inventor
乔丽娟
朱德锐
王嵘
沈国平
龙启福
邢江娃
李永臻
缪增强
王志博
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Qinghai University
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Qinghai University
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4953Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/31Hydrocarbons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37Esters of carboxylic acids
    • A61K8/375Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67Vitamins
    • A61K8/678Tocopherol, i.e. vitamin E
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/001Preparations for care of the lips
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/02Preparations for care of the skin for chemically bleaching or whitening the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/08Anti-ageing preparations

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Cosmetics (AREA)

Abstract

The invention belongs to the technical field of daily skin care products, and particularly relates to a lipstick containing tetrahydropyrimidine and a preparation method thereof, wherein the lipstick comprises the following raw materials in parts by weight: 5-15 parts of tetrahydropyrimidine, 20-30 parts of wax, 20-40 parts of grease, 2-5 parts of emulsifier, 1-3 parts of antioxidant, 8-12 parts of emollient, 0.5-1.5 parts of preservative and 10-20 parts of deionized water. More than 95% of the moisturizing composition of the lipstick containing tetrahydropyrimidine provided by the invention is derived from plants, does not contain essence and chemical preservatives, is green, safe and nontoxic, and has the functions of moisturizing lips, drying resistance, physiological restoration, ultraviolet resistance, aging resistance and the like.

Description

Lipstick containing tetrahydropyrimidine and preparation method thereof
Technical Field
The invention belongs to the technical field of daily skin care products, and particularly relates to a lipstick containing tetrahydropyrimidine and a preparation method thereof.
Background
The dry environment is prone to human skin moisture loss, especially in dry and cold winter or alpine zones. The water loss can cause the damage of dryness, tightness, even chapping and the like to the skin of a human body. If the skin care product is not used for caring, the skin care product can be developed continuously, more serious skin injury can be caused, particularly, the skin on the lips is originally very fragile, sebaceous glands capable of secreting grease do not exist, and a natural protective film is absent after the skin care product is exposed outside for a long time. Not only is easy to lose moisture, but also has no resistance to ultraviolet rays in sunlight. Lip skin is the weakest, most susceptible to aging, of the entire body's skin in combating environmental aggressions. The paint is easy to be damaged by the environment, and the problems of drying, peeling, cracking and the like occur.
The lipstick has the functions of moisturizing and moistening the lips and preventing or preventing the lips from being cracked. At present, lipsticks on the market are various in types and different in functions, although the lipsticks have moistening and health-care effects, most of the lipsticks are not natural substances, some preservatives and essences are added to improve the fragrance of the lipsticks and prolong the shelf life, used coloring agents often contain a small amount of heavy metal elements, and lip allergy can be caused even in a range specified by the state. The heavy metal content (such as lead, arsenic, etc.) of partial lipstick is obviously out of limits, and the lipstick is not good for health after long-term use. For example, the invention patent with application number CN201910673912.8 discloses a pure natural lipstick and a preparation method thereof, the pure natural lipstick prepared from candelilla wax, rice chaff wax, carnauba wax, emollient, vitamin E, preservative, colorant and the like has good compatibility of the components, uniform lipstick color coating, contains preservative, and is not good for health after long-term use. For another example, the invention with application number CN201911053867.2 discloses an edible dendrobium officinale lipstick and a preparation method thereof, wherein a pure natural lipstick product with edible dendrobium officinale as a main component is prepared from natural plant components without pigments or chemical essences, has the effects of moisturizing, resisting bacteria and diminishing inflammation, and can obviously improve the problems of dryness, peeling, inflammation and the like of lips, but the process for preparing the extracting solution is complicated, and the extracting solution can be fused with other components only by crushing through an ultralow temperature wall breaking crushing technology and extracting the extracted oil through ultrasonic water bath low-temperature heating. For another example, an all natural lip balm prepared from emu oil, refined lanolin, yolk oil, shea butter, arnebia oil, olive oil, beeswax and plant essential oil has a short shelf life and is not suitable for mass production, although the all natural lip balm is prepared from pure natural raw materials and does not contain any harmful additives such as preservatives. Therefore, it is imperative to develop a lipstick which is natural in raw materials, obvious in moistening and moisturizing effects, safe, effective and simple in process.
Disclosure of Invention
In view of the above problems, the present invention provides a lipstick containing tetrahydropyrimidine, which can not only moisten skin for a long time and deeply, but also protect skin from being damaged by ultraviolet rays, inhibit melanin generation, and further delay premature aging of skin.
The invention also aims to provide a preparation method of the lip balm. Based on the method, the lip balm with the components uniformly mixed and dispersed and stable system can be prepared.
In order to achieve the purpose, the invention adopts the following technical scheme:
the lip balm containing tetrahydropyrimidine comprises the following raw materials in parts by weight: 5-15 parts of tetrahydropyrimidine, 20-30 parts of wax, 20-40 parts of grease, 2-5 parts of emulsifier, 1-3 parts of antioxidant, 8-12 parts of emollient, 0.5-1.5 parts of preservative and 10-20 parts of deionized water.
Further, the emollient is squalane.
Further, the antioxidant is tocopherol and/or squalane.
Further, the emulsifier is glyceryl oleate citrate.
Further, the preservative is bisabolol.
Further, the wax is one or more of carnauba wax, natural white beeswax, candelilla wax, and microcrystalline wax.
Further, the oil and fat is one or more of jojoba oil, white mineral oil, olive oil, rosehip oil, grape seed oil, macadamia nut oil, avocado oil, sweet almond oil, coconut oil, and shea butter.
Meanwhile, the invention provides a preparation method of the lipstick containing tetrahydropyrimidine, which comprises the following steps:
(1) preparation of the aqueous phase: weighing corresponding parts by weight of tetrahydropyrimidine, placing the tetrahydropyrimidine in a water bath at 60-70 ℃, and stirring until the tetrahydropyrimidine is dissolved;
(2) preparation of oil phase: weighing corresponding parts by weight of emulsifier, squalane, oils and fats, tocopherol and bisabolol, placing in a constant-temperature water bath at 60-70 ℃, and stirring until the components are uniformly mixed;
(3) preparation of basic ingredients: weighing the wax in corresponding weight parts, placing the wax in a constant-temperature water bath at the temperature of 80-85 ℃, and stirring until the wax is uniformly mixed;
(4) mixing the water phase and the oil phase: slowly adding the water phase into the oil phase along a glass rod and stirring along one direction until the water phase is uniformly mixed;
(5) mixing: mixing the mixture obtained in the step (4) and the basic component obtained in the step (3) at the temperature of 80-85 ℃, and uniformly stirring;
(6) molding: and pouring the uniform mixture into a mold, and cooling and forming to obtain the lip balm.
Further, the oil and fat is one or more of jojoba oil, white mineral oil, olive oil, rosehip oil, grape seed oil, macadamia nut oil, avocado oil, sweet almond oil, coconut oil, and shea butter.
Further, the wax is one or more of carnauba wax, natural white beeswax, candelilla wax, and microcrystalline wax.
Tetrahydropyrimidine (Ectoine, l,4,5, 6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid) is a compatible solute synthesized in halophilic or halotolerant bacteria cells and capable of resisting external high-salt stress. Ectoine improves the hydration of the surface of a lipid membrane and enhances the fluidization of the lipid membrane by assisting the osmotic pressure balance inside and outside a cell, thereby improving the capability of the cell membrane to bear extreme environments. The intracellular high-concentration Ectoine interacts with protein molecules, so that the compactness and the functional stability of a protein folding structure are enhanced, the diffusion of water molecules around the protein is slowed down, the surface moisture of the protein is gathered, and the skin moisturizing effect is exerted. Second, Ectoine inhibits tyrosinase activity and melanin production, reduces the formation of freckles or sunburn, and the like. Ectoine is an important secondary metabolite of halophilic microorganisms, has the protective effect on cells, cell membranes, proteins and nucleic acids, and can resist the influence of various adverse factors such as freezing, high temperature, high salt, high pressure, drought, radiation and the like. At present, Ectoine is widely applied to biomedical fields such as drug preparation adjuvants, organ transplantation and preservation, skin wound repair, novel cosmetic research and development, and the like, so that the Ectoine is concerned.
Bisabolol is a sesquiterpene compound, also known as sapogenol, bisabolol. The bisabolol belongs to viscous liquid, has colorless to straw yellow color, and hasIt has a light chrysanthemum fragrance, is easily dissolved in lower alcohol such as ethanol and isopropanol, and is also dissolved in fatty alcohol, glyceride and vinegar, but is hardly dissolved in glycerin and water. Bisabolol is often found in essential oils of Compositae plants, such as the whole herb and flower of Matricaria chamomilla, Brazilian chrysanthemum, and Laurencia odorata. Experiments prove that the alpha-bisabolol has various biological activities of reducing skin inflammation, inhibiting bacteria, resisting stimulation, promoting blood circulation, relieving pain and the like, so that the alpha-bisabolol is widely researched. The bisabolol can effectively inhibit the generation of peroxidase. Has good inhibitory effect on acute inflammation or chronic inflammation. The skin three-dimensional model proves that bisabolol can inhibit LTB caused by PMA (myristoyl phorbol ethyl ester)4(human leukotriene B)4) And IL-l alpha (interleukin l alpha) is released, so that the skin irritation of chemical factors, ultraviolet rays, NaOH and SDS to a human body is relieved, and the effects of preventing and inhibiting the generation and treatment of inflammation are achieved. Bisabolol can inhibit various inflammatory dermatoses such as eczema, allergic contact dermatitis, and irritant contact dermatitis by reducing the content of cAMP in cells. The bisabolol also has obvious effects of relieving swelling and pain caused by trauma. In addition, bisabolol has broad-spectrum antibacterial property, has strong growth inhibition effect on halitosis pathogens, and has an inhibition rate of 99% at a concentration of 1%. Meanwhile, the bisabolol can also effectively inhibit dermatomycosis and has a conditioning effect.
More than 95% of the moisturizing composition of the lipstick containing tetrahydropyrimidine provided by the invention is derived from plants, does not contain essence and chemical preservatives, is green, safe and nontoxic, and has the functions of moisturizing lips, drying resistance, physiological restoration, ultraviolet resistance, aging resistance and the like.
Compared with the prior art, the invention has the following advantages and beneficial effects:
(1) the effective component of the invention is the humectant Ectoine, and the effects of environmental factors (including drying, air pollution, ultraviolet and visible radiation) are reduced by stabilizing water molecules and protecting cell membranes, so that the effects of moisturizing lips, drying resistance and physiological restoration are realized.
(2) More than 95% of the added skin-moistening composition is derived from plants, such as skin-moistening components using emollient such as jojoba oil, rosehip oil and grape seed oil. The lip balm formed by reasonable compatibility is green, safe, nontoxic, good in ductility, convenient to use and better in skin effect.
(3) The added hemiterpene compound bisabolol has various biological activities of reducing skin inflammation, removing melanin, resisting irritation, promoting blood circulation, relieving pain and the like, has broad-spectrum antibacterial action, and can effectively inhibit the growth and reproduction of bacteria. The potential harm to human body caused by the addition of chemical preservative is avoided, and the use safety is improved.
(4) The lipstick has the advantages of few processing technology links, convenient operation, effective control of all parameters in the processing process, effective guarantee of the product percent of pass, obvious improvement of lip chap after the lipstick is used, and obvious effect of fading color spots.
Detailed Description
In order to make the technical solutions of the present invention better understood by those skilled in the art, the present invention is further illustrated below with reference to examples.
The lip balm containing tetrahydropyrimidine comprises the following raw materials in parts by weight: 5-15 parts of tetrahydropyrimidine, 20-30 parts of wax, 20-40 parts of grease, 2-5 parts of emulsifier, 1-3 parts of antioxidant, 8-12 parts of emollient, 0.5-1.5 parts of preservative and 10-20 parts of deionized water.
To further illustrate the present invention and its advantages, the following specific examples are given, it being understood that they are by way of illustration only and not by way of limitation. In the examples described below, all parts and percentages are given by weight.
The invention provides a ectoine-containing lip balm which comprises the following raw materials in parts by weight:
example 1
TABLE 1A lipstick containing tetrahydropyrimidine and its components and mass ratio
Figure BDA0002708395380000051
The emulsifier adopted by the Ectoine-containing lip balm is of natural plant source, and has high purity, no adverse impurities and safety. The added bisabolol has the functions of anti-inflammation and removing melanin, also has broad-spectrum antibacterial action, and can effectively inhibit the growth and reproduction of bacteria. The potential harm to human body caused by the addition of chemical preservative is avoided, and the use safety is improved.
Example 2
TABLE 2 moisture lipstick containing tetrahydropyrimidine and its quality ratio
Figure BDA0002708395380000061
The main functional component Ectoine in the Ectoine-containing lip balm can protect lip skin from various external factors (dryness, air pollution, ultraviolet rays and visible light radiation), so that the anti-aging effect is realized.
Example 3
TABLE 3 composition and weight ratio of ectoine-containing lip balm
Figure BDA0002708395380000062
The main components of grease, wax and the like used in the Ectoine-containing lip balm are natural, and the pure natural vegetable oil such as jojoba oil, rose hip oil and the like can not only increase the tissue vitality of the skin, keep the skin elasticity and restore the natural luster of the dry cracked skin, but also is green, mild, safe, nontoxic, free of any toxic and harmful chemical substance, free of any harm to the health of human bodies and wide in application range.
Example 4 lip gloss Performance evaluation
Evaluation of appearance stability: the glossiness of the appearance is good when the lipstick is observed, no bubbles appear on the surface, a small amount of finished lipstick is uniformly smeared on the face tissues, and the phenomenon of oil stain diffusion is observed, so that the result is shown in the following table.
And (3) illumination experiment: a small amount of finished products are placed in a colorless closed container, and the product is irradiated under the natural light condition for 1 day, 3 days, 5 days, 7 days and 10 days to observe whether the product has changes, and the results are shown in the table below.
Cold and heat resistance test: cold resistance test (-10 ℃ for 24 hours), heat resistance test (45 ℃ for 24 hours), and the results are shown in the following table.
And (3) centrifugal experiment: placing a small amount of lip balm finished product in a centrifuge, adjusting to 5000r/min, centrifuging for 15min, observing whether the shape of the cream is complete and whether the cream has a layering phenomenon or not, and obtaining the result shown in the table below.
TABLE 4 Performance evaluation of a tetrahydropyrimidine containing lip balm
Figure BDA0002708395380000071
The efficacy of the lipstick is evaluated through the effect after trial. 40 (lip dry, peeling) test subjects of 18-25 years of age were selected. The lipstick prepared in examples 1-3 and a middle lipstick (control) on the market were randomly divided into 4 groups, and used all day long, and feedback information was collected after one week, and the results were expressed as an average. The using effects of the ingredients are divided into 4 points: very satisfactory score 4; 3 points of satisfaction; generally 2 minutes; unsatisfactory 1 point. The results are shown in the following table.
TABLE 5 evaluation of Using Effect of Tetrahydropyrimidine-containing lip gloss
Figure BDA0002708395380000081
The heat-resistant and cold-resistant indexes of the lipstick provided by the invention meet the regulations of GB/T26513-2011 lip balm, and the lipstick provided by the invention can keep certain stability at higher and lower temperatures. The products of examples 1-3 performed better or equivalent to the control, and the durability evaluation of example 1 was superior to the control, with no significant differences between the various examples of wettability. The preferred embodiments of the present invention have been described in detail, however, the present invention is not limited to the specific details of the above embodiments, and various changes may be made to the technical solution of the present invention within the technical idea of the present invention, and these simple modifications are included in the protective scope of the present invention.
It should be noted that, in the foregoing embodiments, various specific technical features and steps described in the above embodiments can be combined in any suitable manner, and in order to avoid unnecessary repetition, various possible combinations of the features and steps are not described separately.
In addition, any combination of the various embodiments of the present invention is also possible, and the same should be considered as the disclosure of the present invention as long as it does not depart from the spirit of the present invention.

Claims (10)

1. A lip balm containing tetrahydropyrimidine is characterized in that: the lip balm comprises the following raw materials in parts by weight: 5-15 parts of tetrahydropyrimidine, 20-30 parts of wax, 20-40 parts of grease, 2-5 parts of emulsifier, 1-3 parts of antioxidant, 8-12 parts of emollient, 0.5-1.5 parts of preservative and 10-20 parts of deionized water.
2. A tetrahydropyrimidine containing lip balm according to claim 1 wherein: the emollient is squalane.
3. A tetrahydropyrimidine containing lip balm according to claim 1 wherein: the antioxidant is tocopherol and/or squalane.
4. A tetrahydropyrimidine containing lip balm according to claim 1 wherein: the emulsifier is glyceryl oleate citrate.
5. A tetrahydropyrimidine containing lip balm according to claim 1 wherein: the preservative is bisabolol.
6. A tetrahydropyrimidine containing lip balm according to claim 1 wherein: the wax is one or more of carnauba wax, natural white beeswax, candelilla wax, and microcrystalline wax.
7. A tetrahydropyrimidine containing lip balm according to claim 1 wherein: the oil and fat is one or more of jojoba oil, white mineral oil, oleum Olivarum, fructus Rosae Davuricae oil, grapeseed oil, macadamia nut oil, avocado oil, sweet almond oil, oleum Cocois, and shea butter.
8. The preparation method of the lipstick containing tetrahydropyrimidine is characterized by comprising the following steps:
(1) preparation of the aqueous phase: weighing corresponding parts by weight of tetrahydropyrimidine, placing the tetrahydropyrimidine in a water bath at 60-70 ℃, and stirring until the tetrahydropyrimidine is dissolved;
(2) preparation of oil phase: weighing corresponding parts by weight of emulsifier, squalane, oils and fats, tocopherol and bisabolol, placing in a constant-temperature water bath at 60-70 ℃, and stirring until the components are uniformly mixed;
(3) preparation of basic ingredients: weighing the wax in corresponding weight parts, placing the wax in a constant-temperature water bath at the temperature of 80-85 ℃, and stirring until the wax is uniformly mixed;
(4) mixing the water phase and the oil phase: slowly adding the water phase into the oil phase along a glass rod and stirring along one direction until the water phase is uniformly mixed;
(5) mixing: mixing the mixture obtained in the step (4) and the basic component obtained in the step (3) at the temperature of 80-85 ℃, and uniformly stirring;
(6) molding: and pouring the uniform mixture into a mold, and cooling and forming to obtain the lip balm.
9. The method of claim 8, wherein the ectoine-containing lip balm is prepared by: the oil and fat is one or more of jojoba oil, white mineral oil, oleum Olivarum, fructus Rosae Davuricae oil, grapeseed oil, macadamia nut oil, avocado oil, sweet almond oil, oleum Cocois, and shea butter.
10. The method of claim 8, wherein the ectoine-containing lip balm is prepared by: the wax is one or more of carnauba wax, natural white beeswax, candelilla wax, and microcrystalline wax.
CN202011047282.2A 2020-09-29 2020-09-29 Lipstick containing tetrahydropyrimidine and preparation method thereof Pending CN112245314A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112870116A (en) * 2021-03-22 2021-06-01 皖南医学院 Lip balm for moistening, preserving moisture and repairing lips, preparation method of lip balm, lip balm for moistening, preserving moisture and repairing lips and preparation method of lip balm
CN112999116A (en) * 2021-02-04 2021-06-22 拉芳家化股份有限公司 Lip crack control composition

Citations (1)

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Publication number Priority date Publication date Assignee Title
CN105853326A (en) * 2016-04-12 2016-08-17 丹东康齿灵保洁用品有限公司 Infant lip gloss and making method thereof

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Publication number Priority date Publication date Assignee Title
CN105853326A (en) * 2016-04-12 2016-08-17 丹东康齿灵保洁用品有限公司 Infant lip gloss and making method thereof

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Title
ROLF OHRMANN: "《两种植物来源的新型乳化剂》", 《中国化妆品 (行业版)》 *
张欣等: "《天然产物Ectoine 与Hydroxyectoine的生物工程及医学应用研究进展》", 《天然产物研究与开发》 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112999116A (en) * 2021-02-04 2021-06-22 拉芳家化股份有限公司 Lip crack control composition
CN112870116A (en) * 2021-03-22 2021-06-01 皖南医学院 Lip balm for moistening, preserving moisture and repairing lips, preparation method of lip balm, lip balm for moistening, preserving moisture and repairing lips and preparation method of lip balm

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