A kind of acne-removing composition
Technical field
The present invention relates to cosmetic fields, and in particular to a kind of acne-removing composition.
Background technology
Anti-acne is that the process of whelk is eliminated using certain method.Acne is being commonly called as acne, is called " whelk ", " dark
Sore " or " acne " are a kind of skin diseases caused by hair follicle and sebum adenemphraxis, inflammation.This skin disease is often sent out in blueness
Phase in spring, hormone can stimulate hair growth in people's body, and smegma more many greases of sauce, hair and sebaceous glands is promoted therefore to accumulate
The problems such as many substances, the blocking of initiation horse sky, inflammation, and with small pox skin.But with the quickening pace of modern life, work and
The increase of life stress the problems such as cosmetics improper use, causes the incidence of whelk to rise year by year in addition environmental pollution,
The crowd of morbidity also has the tendency that growth in all ages and classes layer.And small pox is mainly in the greases such as face, shirtfront and upper back point
Vigorous position is secreted, the course of disease is long, easily recurs, and often shows as Whiteheads, blackhead or inflamed papules, serious to have purulence
Packet, tubercle, tumour etc..If inflammation but will obviously cause pain or tenderness, and with seborrhea, not only seriously affect human body
The beauty of face, has an effect on social activity and the psychology of people, make patient occur it is not self-confident, awkward, lose, anxiety, nervous depression etc. it is negative
Face mood, to influence quality of life.Therefore, anti-acne is the important skin care process of people seeking beauty.
It is presently commercially available much to declare the product with acne-removing, although most of can play sterilization and disappear in a short time
Scorching effect, but it is big to the irritation of skin, and small pox is easy recurrent exerbation, and active ingredient absorption difference, causes effect unknown
It is aobvious;Different degrees of pigmentation also is had after some product for resolving poxes anti-acnes, appearance is influenced, the need of consumer cannot be met
It asks.
Invention content
The technical problem to be solved in the present invention is to provide a kind of acne-removing composition is provided, can be inhaled well through skin
It receives, by dredging pore, inhibiting bacteria and diminishing inflammation, Sage Extract, the approach to boost metabolism, plays effective anti-acne effect, and have
Effect improves the pigmentation at small pox position.
In order to achieve the above object, the present invention provides the following technical solution:
A kind of acne-removing composition contains raw material as described below:Purslane extract, licorice root extract, mint extract and
Hypericum Perforatum P.E.
In wherein some embodiments, the purslane extract, licorice root extract, mint extract and pass through leaf company
The mass ratio for sticking up extract is(1~10):(1~10):(1~10):(1~10).
In wherein some embodiments, the acne-removing composition also contains raw material as described below:White willow bark extracts
Object, kaempferia galanga root extract, dried tremella extract, Rhizoma Atractylodis Macrocephalae rhizome extract and houttuynia extract, the white willow bark extract,
Kaempferia galanga root extract, dried tremella extract, Rhizoma Atractylodis Macrocephalae rhizome extract and houttuynia extract mass ratio be(1~10):(1~
10):(1~10):(1~10):(1~10).
Acne-removing composition of the present invention a kind of addition of functional additive can be used as in the common matrix of cosmetics or
In carrier, wherein the cosmetics are facial mask, cream, gel, lotion, Essence, spraying, toner etc., and in cosmetics
In additive amount be 0.1% ~ 1%.
In addition, the present invention also provides a kind of Whelk-eliminating paste, include the component of following mass percent:Caprylic/capric glycerine three
Ester 1 ~ 5%, Parleam 1 ~ 5%, cetostearyl alcohol 1 ~ 3%, olive oil 1 ~ 2%, dimethyl silicone polymer 1 ~ 2%, butter
The smooth stearate 0.1 ~ 0.5% of fruit tree fruit fat 0.1 ~ 1%, polysorbate -60 0.1 ~ 1%, sorb, stearine 0.1 ~
1%, PEG-100 stearates 0.1 ~ 1%, frankincense oil 0.01 ~ 0.1%, glycerine 1 ~ 5%, 1,3- propylene glycol 1 ~ 5%, glycerin polyether -26
1 ~ 3%, Sodium Hyaluronate 0.01 ~ 0.1%, tocopherol acetate 0.1 ~ 1%, glycerol caprylate 0.1 ~ 0.5%, decoyl hydroximic acid 0.1 ~
0.5%, 1,2- pentanediols 0.1 ~ 1%, acrylic acid(Ester)Class/C10-30 alkylol acrylamide acid esters cross-linked polymer 0.1 ~ 0.5%, to hydroxyl
Benzoylformaldoxime 0.1 ~ 0.5%, triethanolamine 0.1 ~ 0.5%, xanthans 0.05 ~ 0.2%, the group with acne-removing described above
Close object 0.1 ~ 1%, water surplus.
Compared with prior art, the device have the advantages that it is as follows:
Acne-removing composition of the present invention is largely tested and is studied through inventor, and selected purslane extract, licorice carry
Take object, mint extract and Hypericum Perforatum P.E, and obtain best mass ratio, can be good at through skin surface and
It is absorbed, into deep layer;The multiple efficacies ingredient being rich in is reconciled mutually, is cooperateed with, and can play stripping aging cutin, dredging hair
Hole inhibiting bacteria and diminishing inflammation, oil-control, boosts metabolism, removes pigmented all-dimensional multi-angle effect, tool caused by whelk
There is excellent anti-acne skin effect.
Specific implementation mode
To make the object, technical solutions and advantages of the present invention clearer, embodiment of the present invention will be made into one below
Step ground detailed description, embodiments of the present invention are not limited thereto, for not specifically specified technological parameter or condition, can refer to
Routine techniques carries out.
Following briefly introduction is made to the fractions of composition:
Purslane extract energy moisturizing, reduces excessive dead skin and cuticula generates, and has antibacterial and small pox skin of releiving
The effect of;Licorice root extract can inhibit the activity of tyrosinase and dopachrome interconvertible enzyme, and then reduce pigmentation, play
Whitening function;Mint extract has the function of heat-clearing, can not only clean skin, moreover it is possible to remove blackhead and acne, and reduce flesh
Skin itch;Hypericum Perforatum P.E has good antioxidation, can effectively remove free radical, reduces oxidative damage;This hair
It is bright that these four ingredients are reconciled mutually, are cooperateed with, it is flat that stripping aging cutin, dredging pore, inhibiting bacteria and diminishing inflammation, adjusting water oil may be implemented
It weighs, boost metabolism, removing the pigmented multiple skin effect caused by whelk, realizing the purpose of anti-acne skin care.
In addition, dried tremella extract not only has antiallergy, anti-aging effects, also there is good moisture-keeping function, and promote collagen
Generation, increase the elasticity of skin;Houttuynia extract has good resisting pathogenic microbes effect, maintains the micro- of skin surface
The ecological balance, and the antianaphylaxis of skin can be increased.With white willow bark extract, kaempferia galanga root extract, Rhizoma Atractylodis Macrocephalae rhizome extract
Purslane extract, licorice root extract, mint extract and Hypericum Perforatum P.E are compounded together, can be further suppressed by Cuo
Acne and inflammation caused by sore Propionibacterium and staphylococcus aureus etc., while the pH value of skin microenvironment is adjusted, inhibit Cuo
The growth of sore pathogenic flora, while there are good moisture-keeping functions, skin water and oil balance is adjusted, environment in skin is improved, is inhibited
The hyperkeratosis of pilosebaceous duct prevents grease blocked pore from acne being caused to be formed.Aquation can also be formed in skin surface
Layer repairs the function barrier of skin while skin care, reduces the formation of depressed scar after acne.
Embodiment 1-5
A kind of Whelk-eliminating paste, including such as the component of following table:
Comparative example 1
Difference lies in be not added with Herba portulacae extract with embodiment 3.
Comparative example 2
Difference lies in be not added with licorice root extract with embodiment 3.
Comparative example 3
Difference lies in be not added with mint extract with embodiment 3.
Comparative example 4
Difference lies in be not added with Hypericum Perforatum P.E with embodiment 3.
Comparative example 5
Difference lies in Herba portulacae extract, licorice root extract, mint extract and pass through in acne-removing composition with embodiment 3
The mass ratio of leaf forsythia suspense extraction is 1:11:1:0.9.
Comparative example 6
Difference lies in be not added with white willow bark extract with embodiment 4.
Comparative example 7
Difference lies in be not added with kaempferia galanga root extract with embodiment 4.
Comparative example 8
Difference lies in be not added with dried tremella extract with embodiment 4.
Comparative example 9
Difference lies in be not added with Rhizoma Atractylodis Macrocephalae rhizome extract with embodiment 4.
Comparative example 10
Difference lies in be not added with houttuynia extract with embodiment 4.
Inhibition experiment to propionibacterium acnes
(1)Test specimen:Whelk-eliminating paste, the propionibacterium acnes bacterial strain of Whelk-eliminating paste, the preparation of comparative example 1 ~ 10 prepared by embodiment 1 ~ 5
3 groups(It is isolated at patients with acne skin lesion);
(2)Test method:
1. the culture of anaerobic bacteria, separation, identification:It will be inoculated in THl0 culture mediums by isolated sample at patients with acne skin lesion
In, with airbag method, 37 DEG C of 72 h of culture in anaerobic jar are placed in, indicator are made with methylene blue, palladium grain is that catalysis is pierced.
2. the separation of anaerobic bacteria
Picking single bacterium colony turns 2 pieces of tablets, and one piece is placed in anaerobic jar, the lower 37 DEG C of pure cultures of anaerobic condition;Another piece with 37 DEG C
Aerobic culture;Result is observed after 48 h.
3. the identification of anaerobic bacteria
Without bacterial growth under aerobic culture;
It is slightly neat to occur uniform form, canescence, the circle of tiny, diameter about 1.O mm protrusions, edge on the tablet of Anaerobic culturel
Bacterium colony, bacterium colony is made into microscopy, visible chromabacterium biolaceum under mirror.It is micro-bend in rodlike or rod-shaped, can one end blunt circle, one end attenuates,
Color is not deep, and cell is single, can arrange or arrange in pairs as the shapes such as " people ", " v ".It is tried again through oxytolerant experiment, catalase test, indoles
It tests, biochemical serial test for identification is propionibacterium acnes.
4. anaerobism drug sensitive test
Inoculation:1 colony inoculation in the bacterium colony more than picking cultivated is on LB plating mediums, the aerobic cultures of 37 0C
24 h rinse 24 h propionibacterium acnes of aerobic culture with sterile saline, and flushing liquor is put into sterile test tube;Using wheat
Family name's turbidimetry is than turbid, and opacity tube is with shaking 12 times is before needed, first than turbid to 3 × 108/mL, then with normal saline dilution to 106/mL
It is spare.
LB plating mediums are inoculated with:The swab stick of sterilizing is dipped into bacterium solution, extra bacterium solution is gone in being squeezed on tube wall, is trained in LB tablets
Even spread on base is supported, and a circle is swept along plate edge ring, covers plate, dry 2 min.By sterile steel bowl (a diameter of 6 mm)
It puts down gently on plating medium, filling it up with the prevention acne composition obtained by embodiment, is put into 37 DEG C of 24 h of aerobic culture, find flat
Without bacterial growth in ware, see there is inhibition zone to be formed after continuing 37 DEG C of 24 h of aerobic culture.Antibacterial circle diameter is surveyed, by 3 groups of inhibition zones
Diameter value is averaged.
Test result:
Chinese medicine antibacterial susceptibility grade classification, with reference to corresponding antibiotic standard ".Inhibition zone diameter>20mm is Gao Min, and 10~20mm is
In it is quick,<10 mm are drug resistance, and the results are shown in Table 2 for specific observation.
Table 2
Whelk-eliminating paste prepared by embodiment 1 ~ 5, which is can be seen that, from the test result of table 2 all has high quick effect(Antibacterial circle diameter>
20mm), and comparative example 1 ~ 5 prepare Whelk-eliminating paste only have in quick effect(10 ~ 20mm of antibacterial circle diameter).Illustrate that Herba portulacae extracts
Object, licorice root extract, mint extract and Hypericum Perforatum P.E can be synergistic, have excellent inhibiting bacteria and diminishing inflammation work(
Effect.
Embodiment 4-5 and embodiment 1-3 comparisons as it can be seen that white willow bark extract, kaempferia galanga root extract, dried tremella extract,
The addition of Rhizoma Atractylodis Macrocephalae rhizome extract and houttuynia extract significantly improves inhibition of the Whelk-eliminating paste to propionibacterium acnes
Effect;And comparative example 6-10 and embodiment 4-5 comparisons as it can be seen that white willow bark extract, kaempferia galanga root extract, dried tremella extract,
Promotion effect can be just embodied when Rhizoma Atractylodis Macrocephalae rhizome extract and houttuynia extract share, and have the function of synergy.
Test 1 oil-control efficacy validation
One, tested crowd
300 adult female volunteers, age between 16 to 35 one full year of life, are randomly divided into 15 groups;
Two, test method
Left and right sides conduct at cheek, temple and corners of the mouth intersection at experiment septum reset or so cheekbone, nose and pupil intersection or so
Test area.Specification subject or care-giver adhere to using daily sooner or later, half face test sample, and another half face only uses clearly
Water wipes.Carry out follow-up within 1 week, 2 weeks after experiment starts, the Whelk-eliminating paste that test is prepared using embodiment 1 ~ 5 respectively, comparative example 1 ~ 10
The Whelk-eliminating paste of preparation and the skin oil and fat changes of contents for using clear water, the test of the same volunteer are complete by the same survey crew
At.
Entirely 4 weeks by a definite date researchers of research carried out clinical test results in the 0th week, 2 weeks, 4 weeks, variation in 2 weeks, variation in 4 weeks
Assessment.Oil-control test result is shown in Table 3.The skin oil and fat content measuring produced using German Courage+Khazaka (CK) company
Instrument Sebumeter is surveyed 3 times and is averaged.
Table 3
The oil-control performance that can be seen that Whelk-eliminating paste prepared by embodiment 1 ~ 3 from the data result of table 3 is apparently higher than comparative example 1 ~ 5
The oil-control performance of the Whelk-eliminating paste of preparation.Illustrate purslane extract, licorice root extract, mint extract and hypericum perforatum extraction
Object is the key component that Whelk-eliminating paste plays oil-control effect, and purslane extract, licorice root extract, mint extract and passes through leaf
The effect of Whelk-eliminating paste is just apparent when forsythia suspense extraction shares, and embodies synergistic function.
Embodiment 4-5 and embodiment 1-3 comparisons as it can be seen that white willow bark extract, kaempferia galanga root extract, dried tremella extract,
The addition of Rhizoma Atractylodis Macrocephalae rhizome extract and houttuynia extract significantly improves the oil-control effect of the Whelk-eliminating paste;And comparative example 6-
10 with embodiment 4-5 comparison as it can be seen that white willow bark extract, kaempferia galanga root extract, dried tremella extract, Rhizoma Atractylodis Macrocephalae rhizome extract and
Promotion effect can be just embodied when houttuynia extract shares, and have the function of synergy.
Test 2 human efficiencies evaluation
Object on probation:The crowd of 20-45 Sui face head's small pox of age, facial skin status and appearance are greasy, pigmentation, cutin
Aging.
Method:Every group of 20 people, Whelk-eliminating paste prepared by the Whelk-eliminating paste and comparative example 1 ~ 10 that respectively prepared by test example 1 ~ 5.
Corresponding product is tested twice sooner or later daily, and other product for resolving poxes or hormone product must not be used during experiment,
The state of 25th day detection skin, as a result such as the following table 4.
Table 4
As can be seen from Table 4, the Whelk-eliminating paste that prepared by embodiment 1 ~ 5 is above comparative example 1 ~ 5 to the improvement of skin.Illustrate horse
Sativa extract, licorice root extract, mint extract and Hypericum Perforatum P.E effectively play stripping aging cutin, oil-control,
The effect of the all-dimensional multi-angles such as the pigmentation caused by whelk is removed, there is excellent anti-acne skin effect, and purslane
The effect of Whelk-eliminating paste is just apparent when extract, licorice root extract, mint extract and Hypericum Perforatum P.E share, and embodies
Synergistic function.
Embodiment 4-5 and embodiment 1-3 comparisons as it can be seen that white willow bark extract, kaempferia galanga root extract, dried tremella extract,
The addition of Rhizoma Atractylodis Macrocephalae rhizome extract and houttuynia extract significantly improves the greasy of the Whelk-eliminating paste, pigmentation, cutin
Aging effect;And comparative example 6-10 is compared with embodiment 4-5 as it can be seen that white willow bark extract, kaempferia galanga root extract, white fungus extract
Object, Rhizoma Atractylodis Macrocephalae rhizome extract and houttuynia extract can just embody improvement when sharing, and have the function of synergy.
The above described is only a preferred embodiment of the present invention, limitation in any form not is done to the present invention, therefore
All contents without departing from technical solution of the present invention, it is made to the above embodiment according to the technical essence of the invention any simply to repair
Change, equivalent variations and modification, in the range of still falling within technical solution of the present invention.