CN111419751A - Soothing composition, preparation method thereof and skin care product containing soothing composition - Google Patents
Soothing composition, preparation method thereof and skin care product containing soothing composition Download PDFInfo
- Publication number
- CN111419751A CN111419751A CN202010329158.9A CN202010329158A CN111419751A CN 111419751 A CN111419751 A CN 111419751A CN 202010329158 A CN202010329158 A CN 202010329158A CN 111419751 A CN111419751 A CN 111419751A
- Authority
- CN
- China
- Prior art keywords
- soothing composition
- soothing
- skin care
- care product
- purslane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 81
- 238000002360 preparation method Methods 0.000 title abstract description 20
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims abstract description 43
- 235000001855 Portulaca oleracea Nutrition 0.000 claims abstract description 33
- 241000219304 Portulacaceae Species 0.000 claims abstract description 33
- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 claims abstract description 23
- 239000004202 carbamide Substances 0.000 claims abstract description 23
- 229940101029 dipotassium glycyrrhizinate Drugs 0.000 claims abstract description 22
- 239000003906 humectant Substances 0.000 claims abstract description 13
- 239000012530 fluid Substances 0.000 claims abstract description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 28
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 22
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 16
- 238000000605 extraction Methods 0.000 claims description 15
- 229940064064 purslane extract Drugs 0.000 claims description 14
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 11
- 239000002994 raw material Substances 0.000 claims description 11
- 239000003795 chemical substances by application Substances 0.000 claims description 10
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 9
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 9
- -1 methyl gluceth-20 Chemical compound 0.000 claims description 8
- FYGDTMLNYKFZSV-URKRLVJHSA-N (2s,3r,4s,5s,6r)-2-[(2r,4r,5r,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5r,6s)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1[C@@H](CO)O[C@@H](OC2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-URKRLVJHSA-N 0.000 claims description 7
- 229920002498 Beta-glucan Polymers 0.000 claims description 7
- 239000003755 preservative agent Substances 0.000 claims description 7
- 230000002335 preservative effect Effects 0.000 claims description 7
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 6
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 6
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 6
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 6
- 235000011187 glycerol Nutrition 0.000 claims description 6
- 229960005150 glycerol Drugs 0.000 claims description 6
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 6
- 239000002798 polar solvent Substances 0.000 claims description 6
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims description 5
- 239000002738 chelating agent Substances 0.000 claims description 5
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 claims description 5
- 230000003020 moisturizing effect Effects 0.000 claims description 5
- 239000003002 pH adjusting agent Substances 0.000 claims description 4
- 229920001223 polyethylene glycol Polymers 0.000 claims description 4
- 229920002545 silicone oil Polymers 0.000 claims description 4
- 239000003381 stabilizer Substances 0.000 claims description 4
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims description 3
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims description 3
- 239000004475 Arginine Substances 0.000 claims description 3
- 241001530056 Athelia rolfsii Species 0.000 claims description 3
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims description 3
- 229920002385 Sodium hyaluronate Polymers 0.000 claims description 3
- 229920002125 Sokalan® Polymers 0.000 claims description 3
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims description 3
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 3
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 3
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims description 3
- CBTVGIZVANVGBH-UHFFFAOYSA-N aminomethyl propanol Chemical compound CC(C)(N)CO CBTVGIZVANVGBH-UHFFFAOYSA-N 0.000 claims description 3
- 239000003963 antioxidant agent Substances 0.000 claims description 3
- 230000003078 antioxidant effect Effects 0.000 claims description 3
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 3
- 229960003237 betaine Drugs 0.000 claims description 3
- 235000019437 butane-1,3-diol Nutrition 0.000 claims description 3
- 229960001631 carbomer Drugs 0.000 claims description 3
- 229920006037 cross link polymer Polymers 0.000 claims description 3
- UQPHVQVXLPRNCX-UHFFFAOYSA-N erythrulose Chemical compound OCC(O)C(=O)CO UQPHVQVXLPRNCX-UHFFFAOYSA-N 0.000 claims description 3
- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 claims description 3
- 229920003063 hydroxymethyl cellulose Polymers 0.000 claims description 3
- 229940031574 hydroxymethyl cellulose Drugs 0.000 claims description 3
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 239000000049 pigment Substances 0.000 claims description 3
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 claims description 3
- 239000002516 radical scavenger Substances 0.000 claims description 3
- 229940010747 sodium hyaluronate Drugs 0.000 claims description 3
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 claims description 3
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 3
- 229940074410 trehalose Drugs 0.000 claims description 3
- 239000000230 xanthan gum Substances 0.000 claims description 3
- 229920001285 xanthan gum Polymers 0.000 claims description 3
- 235000010493 xanthan gum Nutrition 0.000 claims description 3
- 229940082509 xanthan gum Drugs 0.000 claims description 3
- 239000000811 xylitol Substances 0.000 claims description 3
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 3
- 235000010447 xylitol Nutrition 0.000 claims description 3
- 229960002675 xylitol Drugs 0.000 claims description 3
- 239000003205 fragrance Substances 0.000 claims description 2
- 229940058015 1,3-butylene glycol Drugs 0.000 claims 1
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 claims 1
- 229940113120 dipropylene glycol Drugs 0.000 claims 1
- 229940031722 methyl gluceth-20 Drugs 0.000 claims 1
- 235000014593 oils and fats Nutrition 0.000 claims 1
- 229960004063 propylene glycol Drugs 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 24
- 208000003251 Pruritus Diseases 0.000 abstract description 8
- 208000024891 symptom Diseases 0.000 abstract description 6
- 230000006872 improvement Effects 0.000 abstract description 3
- 210000003491 skin Anatomy 0.000 description 50
- 235000013877 carbamide Nutrition 0.000 description 20
- 230000007794 irritation Effects 0.000 description 17
- 230000000052 comparative effect Effects 0.000 description 14
- 239000002537 cosmetic Substances 0.000 description 9
- 238000012360 testing method Methods 0.000 description 9
- 238000003756 stirring Methods 0.000 description 8
- 238000003809 water extraction Methods 0.000 description 8
- 206010022998 Irritability Diseases 0.000 description 7
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 6
- 230000003266 anti-allergic effect Effects 0.000 description 6
- 206010015150 Erythema Diseases 0.000 description 5
- 238000011156 evaluation Methods 0.000 description 5
- 239000002904 solvent Substances 0.000 description 5
- 230000002195 synergetic effect Effects 0.000 description 5
- 208000010668 atopic eczema Diseases 0.000 description 4
- 239000000839 emulsion Substances 0.000 description 4
- 230000007803 itching Effects 0.000 description 4
- 239000002562 thickening agent Substances 0.000 description 4
- 210000003837 chick embryo Anatomy 0.000 description 3
- 239000006071 cream Substances 0.000 description 3
- 238000000855 fermentation Methods 0.000 description 3
- 230000004151 fermentation Effects 0.000 description 3
- 238000004108 freeze drying Methods 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 239000006166 lysate Substances 0.000 description 3
- 239000000419 plant extract Substances 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 238000010992 reflux Methods 0.000 description 3
- 230000002040 relaxant effect Effects 0.000 description 3
- 230000008961 swelling Effects 0.000 description 3
- 229940045136 urea Drugs 0.000 description 3
- CCLARULDIPFTCP-BOYHRMMASA-N (2r,3r,4r,5s)-heptane-1,2,3,4,5,6-hexol Chemical compound CC(O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO CCLARULDIPFTCP-BOYHRMMASA-N 0.000 description 2
- MXOAEAUPQDYUQM-QMMMGPOBSA-N (S)-chlorphenesin Chemical compound OC[C@H](O)COC1=CC=C(Cl)C=C1 MXOAEAUPQDYUQM-QMMMGPOBSA-N 0.000 description 2
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 2
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 2
- TXFPEBPIARQUIG-UHFFFAOYSA-N 4'-hydroxyacetophenone Chemical compound CC(=O)C1=CC=C(O)C=C1 TXFPEBPIARQUIG-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 229920000832 Cutin Polymers 0.000 description 2
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 2
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 230000000172 allergic effect Effects 0.000 description 2
- 235000006708 antioxidants Nutrition 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- 230000000740 bleeding effect Effects 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 229960003993 chlorphenesin Drugs 0.000 description 2
- 230000003750 conditioning effect Effects 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 239000008367 deionised water Substances 0.000 description 2
- 229910021641 deionized water Inorganic materials 0.000 description 2
- 238000007599 discharging Methods 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 125000005456 glyceride group Chemical group 0.000 description 2
- 239000004519 grease Substances 0.000 description 2
- 238000000227 grinding Methods 0.000 description 2
- 229920000591 gum Polymers 0.000 description 2
- 210000004379 membrane Anatomy 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 2
- 229960005323 phenoxyethanol Drugs 0.000 description 2
- 230000037307 sensitive skin Effects 0.000 description 2
- 238000010257 thawing Methods 0.000 description 2
- WTVHAMTYZJGJLJ-UHFFFAOYSA-N (+)-(4S,8R)-8-epi-beta-bisabolol Natural products CC(C)=CCCC(C)C1(O)CCC(C)=CC1 WTVHAMTYZJGJLJ-UHFFFAOYSA-N 0.000 description 1
- RGZSQWQPBWRIAQ-CABCVRRESA-N (-)-alpha-Bisabolol Chemical compound CC(C)=CCC[C@](C)(O)[C@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-CABCVRRESA-N 0.000 description 1
- LQIAZOCLNBBZQK-UHFFFAOYSA-N 1-(1,2-Diphosphanylethyl)pyrrolidin-2-one Chemical compound PCC(P)N1CCCC1=O LQIAZOCLNBBZQK-UHFFFAOYSA-N 0.000 description 1
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 239000005711 Benzoic acid Substances 0.000 description 1
- 206010053567 Coagulopathies Diseases 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 206010012434 Dermatitis allergic Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 229940123457 Free radical scavenger Drugs 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- XPJVKCRENWUEJH-UHFFFAOYSA-N Isobutylparaben Chemical compound CC(C)COC(=O)C1=CC=C(O)C=C1 XPJVKCRENWUEJH-UHFFFAOYSA-N 0.000 description 1
- 229920000604 Polyethylene Glycol 200 Polymers 0.000 description 1
- 229920002556 Polyethylene Glycol 300 Polymers 0.000 description 1
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 241000219295 Portulaca Species 0.000 description 1
- 201000004681 Psoriasis Diseases 0.000 description 1
- 241000235346 Schizosaccharomyces Species 0.000 description 1
- 206010070834 Sensitisation Diseases 0.000 description 1
- 244000044822 Simmondsia californica Species 0.000 description 1
- 235000004433 Simmondsia californica Nutrition 0.000 description 1
- 206010040830 Skin discomfort Diseases 0.000 description 1
- 206010040844 Skin exfoliation Diseases 0.000 description 1
- 206010051788 Sticky skin Diseases 0.000 description 1
- 206010042674 Swelling Diseases 0.000 description 1
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 1
- NENOAJSZZPODGJ-OIMNJJJWSA-N [(2r)-2-[(2r,3r,4s)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] octanoate Chemical compound CCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O NENOAJSZZPODGJ-OIMNJJJWSA-N 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 239000013566 allergen Substances 0.000 description 1
- RGZSQWQPBWRIAQ-LSDHHAIUSA-N alpha-Bisabolol Natural products CC(C)=CCC[C@@](C)(O)[C@@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-LSDHHAIUSA-N 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 201000008937 atopic dermatitis Diseases 0.000 description 1
- 239000010480 babassu oil Substances 0.000 description 1
- 235000010233 benzoic acid Nutrition 0.000 description 1
- 229940094978 bis-peg-18 methyl ether dimethyl silane Drugs 0.000 description 1
- 229940036350 bisabolol Drugs 0.000 description 1
- HHGZABIIYIWLGA-UHFFFAOYSA-N bisabolol Natural products CC1CCC(C(C)(O)CCC=C(C)C)CC1 HHGZABIIYIWLGA-UHFFFAOYSA-N 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 210000003711 chorioallantoic membrane Anatomy 0.000 description 1
- 230000035602 clotting Effects 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000004042 decolorization Methods 0.000 description 1
- 230000007123 defense Effects 0.000 description 1
- 238000004332 deodorization Methods 0.000 description 1
- 230000035618 desquamation Effects 0.000 description 1
- 238000001784 detoxification Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 239000004205 dimethyl polysiloxane Substances 0.000 description 1
- 230000003467 diminishing effect Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000003974 emollient agent Substances 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 235000010228 ethyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004403 ethyl p-hydroxybenzoate Substances 0.000 description 1
- 229940043351 ethyl-p-hydroxybenzoate Drugs 0.000 description 1
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 description 1
- 230000004992 fission Effects 0.000 description 1
- 229930003944 flavone Natural products 0.000 description 1
- 150000002212 flavone derivatives Chemical class 0.000 description 1
- 235000011949 flavones Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000008236 heating water Substances 0.000 description 1
- IIRDTKBZINWQAW-UHFFFAOYSA-N hexaethylene glycol Chemical compound OCCOCCOCCOCCOCCOCCO IIRDTKBZINWQAW-UHFFFAOYSA-N 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000008141 laxative Substances 0.000 description 1
- 230000002475 laxative effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229910001629 magnesium chloride Inorganic materials 0.000 description 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
- 235000019341 magnesium sulphate Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 230000037311 normal skin Effects 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 229940086539 peg-7 glyceryl cocoate Drugs 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 235000017807 phytochemicals Nutrition 0.000 description 1
- 229930000223 plant secondary metabolite Natural products 0.000 description 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 229930182490 saponin Natural products 0.000 description 1
- 150000007949 saponins Chemical class 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- 230000009759 skin aging Effects 0.000 description 1
- 230000008591 skin barrier function Effects 0.000 description 1
- 230000000391 smoking effect Effects 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 235000019605 sweet taste sensations Nutrition 0.000 description 1
- 230000009044 synergistic interaction Effects 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 1
- 239000001243 zingiber officinale rosc. root absolute Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/75—Anti-irritant
Abstract
The invention relates to a soothing composition, a preparation method thereof and a skin care product containing the soothing composition. The soothing composition comprises the following components, based on the total mass of the soothing composition: humectant: 0.01-20%, preferably 8-18%; fluid regulator: 0.02-2%, preferably 0.05-1.5%; pH regulator: 0 to 2%, preferably 0.001 to 2%; urea: 1% -10%, preferably 1% -8%; extracting the purslane: 1% -10%, preferably 1% -8%; dipotassium glycyrrhizinate: 0.05 to 3 percent, preferably 0.05 to 2 percent. The soothing composition disclosed by the invention can relieve the symptoms of skin redness and pruritus, and the aims of synergy and improvement of the skin soothing effect are achieved by reasonably proportioning the urea, the purslane extracting solution and the dipotassium glycyrrhizinate.
Description
Technical Field
The invention relates to a soothing composition, a preparation method thereof and a skin care product containing the soothing composition, and belongs to the field of cosmetics.
Background
In recent years, many consumers have a problem that their own immune systems are disordered due to environmental pollution, pressure on work, alcohol smoking, improper diet and sleep, and improper use or illegal use of ingredients of their care products results in loss of the moisture-retaining barrier function of the skin, which leads to red swelling, prickling, and water shortage and tension of the skin. Namely, when the skin is subjected to various irritations such as cosmetics with adverse reactions, pollen, certain foods, polluted air, severe environment and the like, the skin is caused to have abnormal phenomena such as redness and swelling, itching, desquamation, allergic dermatitis and the like, and the skin is particularly serious for people with allergic constitution.
In order to get rid of the trouble of sensitive skin, products for relieving the skin and relieving stabbing pain in time are developed and become irresistible, so that the moisturizing and relieving composition is added, the stabbing and painful skin is relieved effectively, the sensitive skin is smeared for a long time in a smooth way, and the skin can recover the due barrier moisturizing function of the normal skin.
CN110623895A discloses an anti-allergy and soothing composition, a preparation method and an application thereof, wherein the anti-allergy and soothing composition comprises, by mass, 2-24% of a humectant, 0.1-0.8% of a thickener, 1-6% of a first plant extract, 1-10% of oat β -glucan, 1-8% of a second plant extract, 0.3-0.9% of a preservative, and 50.3-94.6% of a solvent, but the anti-allergy and soothing composition needs two plant extracts, and is high in cost and poor in soothing effect.
CN110101651A discloses a laxative essence containing a schizosaccharomyces cerevisiae fermentation product lysate and a preparation method thereof. The composite material comprises the following raw materials in parts by weight: 1-10 parts of polyhydric alcohol, 1-10 parts of humectant, 0.5-10 parts of emollient, 0.5-5 parts of emulsifier, 0.1-2 parts of thickener, 0.1-2 parts of pH regulator, 0.1-5 parts of anti-allergy soothing agent, 0.1-10 parts of skin conditioner, 0.1-1 part of preservative, 0.01-0.05 part of essence and 100 parts of deionized water. Wherein the anti-allergy soothing agent is at least one of a cracked yeast fermentation product lysate, dipotassium glycyrrhizinate, a purslane extract, bisabolol and a ginger root extract. The soothing and repairing essence contains the lysate of the yeast fermentation product of the secondary fission, so that the cost is higher and the soothing effect is poor.
In view of the technical problems in the prior art, the development of a skin care composition capable of relieving skin discomfort is an urgent technical problem to be solved by applying the composition to cosmetics, particularly cosmetics used by people with allergic constitution, so as to reduce or eliminate irritation and sensitization of irritation allergens such as raw material components contained in the cosmetics.
Disclosure of Invention
Problems to be solved by the invention
In view of the technical problems of the prior art, the invention firstly provides a soothing composition and a preparation method thereof. The soothing composition can relieve the symptoms of skin redness and pruritus, and achieves the purpose of synergistic interaction and an effect of soothing the skin through reasonable proportioning of urea, purslane extract and dipotassium glycyrrhizinate.
Further, the present invention also provides a skin care product comprising the soothing composition.
Means for solving the problems
The invention provides a soothing composition which comprises the following components in percentage by mass of the total mass of the soothing composition:
humectant: 0.01-20%, preferably 8-18%;
fluid regulator: 0.02-2%, preferably 0.05-1.5%;
pH regulator: 0 to 2%, preferably 0.001 to 2%;
urea: 1% -10%, preferably 1% -8%;
extracting the purslane: 1% -10%, preferably 1% -8%;
dipotassium glycyrrhizinate: 0.05 to 3 percent, preferably 0.05 to 2 percent.
The soothing composition comprises one or more of glycerol, propylene glycol, dipropylene glycol, 1, 3-butanediol, trehalose, xylitol, betaine, glyceryl polyether-26, β -glucan, methyl glucitol polyether-20, erythrulose, biogum-1, oat β -glucan, acetyl chitosamine, polyethylene glycols, water-soluble grease, water-soluble silicone oil and sodium hyaluronate.
The soothing composition comprises one or more of carbomer, xanthan gum, sclerotium rolfsii gum, hydroxymethyl cellulose, hydroxyethyl cellulose, acrylic acid/C10-30 alkanol acrylate cross-linked polymer and sodium polyacrylate.
The relaxing composition according to the present invention, wherein the pH adjusting agent comprises one or a combination of two or more of sodium hydroxide, potassium hydroxide, triethanolamine, aminomethyl propanol, and arginine.
The relieving composition provided by the invention is prepared by a method for preparing the purslane extracting solution by using a polar solvent extraction mode; preferably, the polar solvent comprises water and/or an alcohol.
The relieving composition provided by the invention comprises a preparation method of the purslane extracting solution, wherein the preparation method comprises the following steps: extracting the purslane raw material by using water, and then extracting by using alcohol.
The soothing composition further comprises one or more of a free radical scavenger, a chelating agent, an antioxidant, a film forming agent, a stabilizer, a preservative, a perfume and a pigment.
The invention also provides a skin care product comprising the soothing composition according to the invention, preferably in an amount of 2-23%, preferably 2-18% by mass of the total mass of the skin care product.
The skin care product comprises one or more of an aqueous skin care product, a gel skin care product, an emulsion skin care product and a cream skin care product.
The present invention also provides a process for the preparation of the soothing composition according to the present invention, wherein the process comprises the step of mixing the components of the soothing composition.
ADVANTAGEOUS EFFECTS OF INVENTION
The soothing composition disclosed by the invention can relieve the symptoms of skin redness and pruritus, and the aims of synergy and improvement of the skin soothing effect are achieved by reasonably proportioning the urea, the purslane extracting solution and the dipotassium glycyrrhizinate.
Furthermore, the preparation method of the soothing composition is simple and feasible, the raw materials are easy to obtain, and the soothing composition is suitable for mass production.
Further, the skin care product of the present invention comprising the soothing composition can relieve the symptoms of redness and itching of the skin and increase the soothing effect of the skin.
Detailed Description
Various exemplary embodiments, features and aspects of the invention will be described in detail below. The word "exemplary" is used exclusively herein to mean "serving as an example, embodiment, or illustration. Any embodiment described herein as "exemplary" is not necessarily to be construed as preferred or advantageous over other embodiments.
Furthermore, in the following detailed description, numerous specific details are set forth in order to provide a better understanding of the present invention. It will be understood by those skilled in the art that the present invention may be practiced without some of these specific details. In other instances, methods, means, devices and steps which are well known to those skilled in the art have not been described in detail so as not to obscure the invention.
< first aspect >
In a first aspect the present invention provides a soothing composition comprising the following components, based on the total mass of the soothing composition:
humectant: 0.01-20%, preferably 8-18%;
fluid regulator: 0.02-2%, preferably 0.05-1.5%;
pH regulator: 0 to 2%, preferably 0.001 to 2%;
urea: 1% -10%, preferably 1% -8%;
extracting the purslane: 1% -10%, preferably 1% -8%;
dipotassium glycyrrhizinate: 0.05 to 3 percent, preferably 0.05 to 2 percent.
The soothing composition disclosed by the invention can relieve the symptoms of skin redness and pruritus, and the aims of synergy and improvement of the skin soothing effect are achieved by reasonably proportioning the urea, the purslane extracting solution and the dipotassium glycyrrhizinate.
Urea
Urea, also known as carbamide (carbomide), is an organic compound consisting of carbon, nitrogen, oxygen, and hydrogen, and is a white crystal. Urea has good permeability, has a certain defense effect on water loss in skin, can reduce water loss of epidermis layers or outer layers of skin, can remove aged cutin, increases the water retention effect of cutin, can be used for helping to treat eczema or psoriasis and enhancing skin barrier.
In the present invention, by using urea, the soothing effect can be further improved, so that the symptoms of red swelling and itching of the skin can be relieved. Specifically, in the present invention, the urea is added in an amount of 1% to 10%, preferably 1% to 8%, more preferably 2% to 8%, based on the total mass of the soothing composition. If the addition amount of the urea is less than 1 percent, the synergistic skin-soothing effect is not obvious; if the amount of urea added is more than 10%, the cost is high and the effect of the extra urea cannot be further increased.
Purslane extract
The purslane extracting solution is rich in plant polysaccharide and vitamin, so that the purslane extracting solution can nourish and lubricate the skin, promote the physiological function of epithelial cells to be normal, and reduce the generation of dead skin and cuticle caused by dryness; wherein, the purslane extractive solution contains flavone and saponin which can remove free radicals, resist oxidation and delay skin aging. In the present invention, the purslane extract is used to soothe the skin and to suppress skin itching due to dryness.
In the invention, the purslane extracting solution can be obtained by purchasing, or can be prepared by extracting through a cold water extraction method.
Preferably, the preparation method of the purslane extracting solution comprises the steps of extracting by using a polar solvent; preferably, the polar solvent comprises water and/or an alcohol. The preparation method of the purslane extracting solution comprises the following steps: extracting the purslane raw material by using water, and then extracting by using alcohol.
Specifically, the preparation method of the extract of the portulaca palmata comprises the following steps:
water extraction: soaking and extracting the purslane raw material by using water to obtain a water extraction product; the purslane raw material can be purslane powder obtained by grinding purslane.
Alcohol extraction step: and continuously carrying out reflux extraction on the dried water extraction product by using alcohol to obtain an alcohol extraction product.
In the water extraction step, the addition amount of the water is 8-12 times of the weight of the purslane raw material, the temperature of the water is 70-90 ℃, and the extraction time is 1-3 hours; in the alcohol extraction step, the addition amount of the alcohol is 8-12 times of the weight of the purslane raw material, the extraction temperature is 40-60 ℃, the extraction time is 1-3 hours, and the concentration of the alcohol is 70-80%. The alcohol can be any feasible alcohol product such as ethanol, propanol, etc.
Further, between the step of water extraction and the step of alcohol extraction, the method also comprises the step of decolorization: decoloring the water extraction product by using activated carbon to obtain a decolored product; then, the dried decolorized product is continuously extracted by refluxing by using alcohol to obtain an alcohol extraction product. Specifically, the mass fraction (addition amount) of the activated carbon is 0.1-1%, the decoloring temperature is 50-70 ℃, and the decoloring time is 0.1-1 hour.
For the alcohol extraction product, in order to obtain a purslane extract with more excellent performance, the alcohol extraction product can be dried to obtain the purslane extract. For the drying, it is preferable to perform the drying by freeze-drying. Thereafter, the purslane extract may be dissolved in a solvent to obtain a purslane extract. Typically, the solvent is water. The content of the purslane extract is 5-20% of the total mass of the purslane extract.
Further, in the present invention, the amount of the purslane extract added is 1% to 10%, preferably 1% to 8%, more preferably 2% to 8%, and still more preferably 3% to 6% based on the total mass of the soothing composition. If the adding amount of the purslane extracting solution is less than 1 percent, the effect is not obvious; if the addition amount of the purslane extracting solution is higher than 10%, the cost is higher, and the effect of the redundant purslane extracting solution is not obviously increased.
Glycyrrhizic acid dipotassium salt
The dipotassium glycyrrhizinate is white or white-like fine powder, has special sweet taste, good water solubility and pure mouthfeel. The dipotassium glycyrrhizinate has multiple effects of bacteriostasis, inflammation diminishing, detoxification, anti-allergy, deodorization and the like. Has wide application in the industries of medicine, cosmetics, daily chemicals, food and the like. In the invention, the dipotassium glycyrrhizinate can generate a synergistic effect with the purslane extracting solution and the urea, so that the effect of relieving the skin is further improved.
Specifically, the adding amount of dipotassium glycyrrhizinate is 0.05-3%, preferably 0.05-0.8%, more preferably 0.1-0.8%, and even more preferably 0.1-0.6% based on the total mass of the soothing composition. If the addition amount of dipotassium glycyrrhizinate is less than 0.05%, the synergistic effect of relieving the skin is not obvious; if the added amount of dipotassium glycyrrhizinate is more than 3%, the cost is high, and the effect of the excess dipotassium glycyrrhizinate cannot be further increased.
Moisture-retaining agent
In the present invention, a moisturizing agent may be added to provide a certain moisturizing effect to the soothing composition of the present invention. The addition amount of the humectant is 0.01-20%, preferably 8-18% by total mass of the soothing composition; for example: the humectant may be added in an amount of 1%, 3%, 5%, 7%, 9%, 10%, 12%, 14%, 16%, 19%, etc. If the content of the humectant is less than 0.01%, the sustained moisture-retention property of the soothing composition will not be satisfactory; if the humectant content is greater than 20%, the soothing composition has a poor feel due to a sticky skin feel.
Specifically, the humectant comprises one or a combination of more than two of glycerol, propylene glycol, dipropylene glycol, 1, 3-butanediol, trehalose, xylitol, betaine, glycerol polyether-26, β -glucan, methyl glucitol polyether-20, erythrulose, biogum glycocoll-1, oat β -glucan, acetyl chitosamine, polyethylene glycols, water-soluble grease, water-soluble silicone oil and sodium hyaluronate.
Wherein, the polyethylene glycol can be selected from one or the combination of more than two of PEG-8, PEG-32, PEG-200, PEG-300 and PEG-400; the water-soluble oil and fat may be one or a combination of two or more selected from the group consisting of PEG-7 glyceryl cocoate, babassu oil glyceryl polyether-8 esters, PEG-6 caprylic/capric glycerides, PEG-8 caprylic/capric glycerides, and hydrolyzed jojoba esters; as the water-soluble silicone oil, it may be selected from one or a combination of two or more of bis-PEG-18 methyl ether dimethylsilane and PEG-12 polydimethylsiloxane.
Preferably, in the present invention, the humectant is one or a combination of two or more selected from glycerin, propylene glycol, and dipropylene glycol.
Fluid conditioning agent
In the present invention, fluid conditioning agents may be used to control the consistency of the soothing composition. Specifically, in the invention, the fluid regulator comprises one or more of carbomer, xanthan gum, sclerotium rolfsii gum, hydroxymethyl cellulose, hydroxyethyl cellulose, acrylic acid/C10-30 alkanol acrylate cross-linked polymer and sodium polyacrylate.
Preferably, the fluid regulator comprises hydroxyethyl cellulose. The hydroxyethyl cellulose has good solubility and viscosity, and can keep the original shape of cosmetic in cold and hot seasons, and has moisture keeping effect.
In the present invention, the thickening agent is added in an amount of 0.02 to 2%, preferably 0.05 to 1.5%, based on the total mass of the soothing composition. If the content of the thickener is more than 2%, the soothing composition has a poor feeling to the touch due to stickiness and thickness.
pH regulator
In the present invention, some pH adjusting agents may be added appropriately to make the pH of the soothing composition of the present invention more compatible with the skin's needs. Specifically, the pH regulator comprises one or more of sodium hydroxide, potassium hydroxide, triethanolamine, aminomethyl propanol and arginine.
In the present invention, the pH adjusting agent is added in an amount of 0 to 2%, preferably 0.001 to 2%, based on the total mass of the soothing composition.
Other ingredients
In the present invention, the soothing composition may also contain other ingredients commonly used in cosmetics. The other components are not particularly limited in the present invention, and may be some cosmetic components commonly used in the art. For example, the soothing composition may further comprise one or a combination of two or more of a solvent, a radical scavenger, a chelating agent, an antioxidant, a film former, a stabilizer, a preservative, a fragrance, and a pigment.
Specifically, the preservative can comprise one or more of alkyl p-hydroxybenzoate compounds, p-hydroxyacetophenone, phenoxyethanol, chlorphenesin, sorbitan caprylate, benzoic acid and sodium benzoate; one or more of phenoxyethanol and chlorphenesin are preferably used.
Wherein the alkyl p-hydroxybenzoate compound comprises one or more of methyl p-hydroxybenzoate, ethyl p-hydroxybenzoate, propyl p-hydroxybenzoate and isobutyl p-hydroxybenzoate. The stabilizer comprises one or the combination of more than two of sodium chloride, magnesium chloride and magnesium sulfate; the chelating agent is one or two of EDTA-2Na and EDTA-4 Na. Generally, the solvent is water.
The soothing composition disclosed by the invention is prepared by selecting mild and high-safety raw materials, and finally achieves the effects of synergistic soothing and efficient soothing by using the interaction among urea, the purslane extracting solution and dipotassium glycyrrhizinate. The soothing composition used in the present invention is used in significantly less amount compared to a single soothing agent with the same soothing effect.
<Second aspect of the invention>
In a second aspect of the invention there is provided a skin care product comprising a soothing composition according to the first aspect of the invention. Preferably, the soothing composition is added in an amount of 2% to 23%, preferably 2% to 18%, more preferably 2% to 15% by weight of the total mass of the skin care product; further preferably 2.1% to 10.5%. When the content of the soothing composition is 2% to 23%, excellent technical effects can be obtained.
Specifically, in the invention, the skin care product comprises one or more of an aqueous skin care product, a gel skin care product, an emulsion skin care product or a cream skin care product.
Further, the water-based skin care product can include, but is not limited to, one or a combination of more than two of soothing water, soothing essence and soothing mask; the gel type skin care product can comprise one or the combination of more than two of but not limited to relaxing gel and relaxing gel-shaped sleep mask; emulsion type skin care products may include, but are not limited to, soothing emulsions and the like; the cream-type skin care product may include, but is not limited to, soothing cream, etc.
<Third aspect of the invention>
A third aspect of the present invention provides a process for the preparation of a soothing composition according to the present invention, comprising the step of mixing the components of the soothing composition.
Specifically, the preparation method comprises the following steps:
1) heating water, optional chelating agent, optional pH regulator, humectant and fluid regulator to 75-85 deg.C, stirring for dissolving completely, and stirring for 10-30 min;
2) cooling to 30-50 deg.C under stirring, adding urea, herba Portulacae extractive solution, dipotassium glycyrrhizinate and optionally antiseptic and other components, stirring and dissolving completely;
3) and (6) checking to be qualified and discharging.
Examples
Embodiments of the present invention will be described in detail below with reference to examples, but those skilled in the art will appreciate that the following examples are only illustrative of the present invention and should not be construed as limiting the scope of the present invention. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products commercially available.
Among these, urea is available from merck, germany.
Dipotassium glycyrrhizinate was purchased from pan-planted phytochemicals group.
The preparation method of the purslane extracting solution comprises the following steps:
water extraction: grinding the weighed purslane into powder, extracting with water at 80 ℃ for 2 hours, wherein the amount of the water is 10 times that of the purslane at the 1 st time;
and (3) decoloring: adding 0.5% of active carbon by mass, decoloring for 0.5h at 60 ℃, and centrifugally filtering to obtain a decolored product for later use;
alcohol extraction step: taking 20g of a decolorized product obtained by freeze drying, performing reflux extraction with 75% ethanol at 50 ℃ according to a material-liquid ratio of 1:10 to obtain an extracting solution, and performing centrifugal filtration to obtain an alcohol extraction product; concentrating, freeze-drying to obtain herba Portulacae extract, and diluting with 10 times of water to obtain herba Portulacae extractive solution.
Examples 1 to 5
The soothing compositions of examples 1-5 were prepared according to the content of each component in table 1 below, based on 100g total weight.
TABLE 1
The steps of the preparation of the soothing composition of examples 1-5 above are as follows:
1) heating deionized water, EDTA-2Na, glycerol, dipropylene glycol and hydroxyethyl cellulose to 80 ℃, stirring for dissolving completely, and keeping the temperature and stirring for 20 minutes;
2) stirring and cooling to 40 ℃, adding urea, purslane extract, dipotassium glycyrrhizinate and preservative, stirring and dissolving completely;
3) and (6) checking to be qualified and discharging.
Comparative examples 1 to 7
The soothing compositions of comparative examples 1 to 7 were prepared according to the preparation methods of examples 1 to 5 in accordance with the contents of the respective components in the following table 2 by total weight of 100 g. Wherein, the preparation method of the soothing composition of comparative examples 1 to 7 is the same as that of example 1 except for urea, purslane extract and dipotassium glycyrrhizinate.
TABLE 2
Comfort Effect test
1. Experimental methods
To verify that the soothing composition of the present invention has reduced irritancy efficacy, the following experiment was conducted:
experimental basis and methods: the community standard T/SHRH 011 and 2018 chick embryo chorioallantoic membrane test is carried out, the irritation test is carried out according to the standard method, and the ES value is judged and recorded.
2. Laboratory instruments and subjects: the experimental subject is SPF-grade white-skinned chicken fertilized chick embryo. And (3) testing a product: soothing compositions of examples 1-5, comparative examples 1-7.
3. Processing test data: based on the degree of bleeding, coagulation and vessel thawing occurring on the CAM membrane, 0, 1, 2, and 3 points of evaluation were given, respectively, and the ES average score was calculated according to the following formula:
ES (sum of extent of bleeding, clotting and vascular thawing observed in 6 chick embryos)/3
Evaluation criteria: the evaluation criteria are shown in table 3:
table 3: ES value corresponding to irritation evaluation criteria
| Endpoint scoring | Irritation classification |
| ES≤12 | Non/light irritability |
| 12＜ES＜16 | Moderate irritation |
| ES≥16 | Severe irritation |
The specific test results are shown in table 4:
table 4: sample CAM Membrane irritation test results
| Sample (I) | Endpoint scoring | Irritation classification |
| Example 1 | 11.2 | Non/light irritability |
| Example 2 | 10.1 | Non/light irritability |
| Example 3 | 8.2 | Non/light irritability |
| Example 4 | 6.8 | Non/light irritability |
| Example 5 | 6.5 | Non/light irritability |
| Comparative example 1 | 14.6 | Moderate irritation |
| Comparative example 2 | 12.2 | Moderate irritation |
| Comparative example 3 | 12.6 | Moderate irritation |
| Comparative example 4 | 11.0 | Non/light irritability |
| Comparative example 5 | 13.1 | Moderate irritation |
| Comparative example 6 | 12.4 | Moderate irritation |
| Comparative example 7 | 13.0 | Moderate irritation |
And (3) evaluation of test results: as can be seen from Table 4, the addition of the soothing compositions of examples 1-5 of the present invention is significantly less irritating than the soothing compositions of comparative examples 1-3, 5-7, indicating that the compositions effectively reduce the irritation of the overall formulation and the soothing anti-irritation efficacy of the present invention is well-documented. The test results of the soothing compositions of examples 1-5 and comparative examples 1-3 and 5-7 show that the three efficacies have excellent synergistic effect.
For comparative example 4, when dipotassium glycyrrhizinate alone was used, it was possible to obtain superior technical effects, but the cost was high.
The above embodiments are preferred embodiments of the present invention, but the present invention is not limited to the above embodiments, and any other changes, modifications, substitutions, combinations, and simplifications which do not depart from the spirit and principle of the present invention should be construed as equivalents and are included in the scope of the present invention.
Claims (10)
1. A soothing composition comprising, based on the total mass of the soothing composition:
humectant: 0.01-20%, preferably 8-18%;
fluid regulator: 0.02-2%, preferably 0.05-1.5%;
pH regulator: 0 to 2%, preferably 0.001 to 2%;
urea: 1% -10%, preferably 1% -8%;
extracting the purslane: 1% -10%, preferably 1% -8%;
dipotassium glycyrrhizinate: 0.05 to 3 percent, preferably 0.05 to 2 percent.
2. A soothing composition according to claim 1, wherein the moisturizing agent comprises one or a combination of two or more of glycerin, propylene glycol, dipropylene glycol, 1, 3-butylene glycol, trehalose, xylitol, betaine, glyceryl polyether-26, β -glucan, methyl gluceth-20, erythrulose, biogum-1, oat β -glucan, acetyl chitosamine, polyethylene glycols, water-soluble oils and fats, water-soluble silicone oil, and sodium hyaluronate.
3. A soothing composition according to claim 1 or 2, wherein the fluid regulating agent comprises one or a combination of more than two of carbomer, xanthan gum, sclerotium rolfsii, hydroxymethyl cellulose, hydroxyethyl cellulose, acrylic/C10-30 alkanol acrylate crosspolymer, sodium polyacrylate.
4. A soothing composition according to any of claims 1-3, wherein the pH adjusting agent comprises one or a combination of two or more of sodium hydroxide, potassium hydroxide, triethanolamine, aminomethyl propanol, arginine.
5. A soothing composition according to any one of claims 1 to 4, wherein the purslane extract is prepared by a method comprising extraction with a polar solvent; preferably, the polar solvent comprises water and/or an alcohol.
6. The soothing composition of claim 5, wherein the purslane extractive solution is prepared by a method comprising: extracting the purslane raw material by using water, and then extracting by using alcohol.
7. A soothing composition according to any of claims 1-6, further comprising one or a combination of more than two of a radical scavenger, a chelating agent, an antioxidant, a film former, a stabilizer, a preservative, a fragrance, a pigment.
8. A skin care product comprising a soothing composition according to any of claims 1 to 7, preferably in an amount of 2% to 23%, preferably 2% to 18% by weight of the total mass of the skin care product.
9. The skin care product of claim 8, wherein the skin care product comprises one or a combination of more than two of an aqueous-type skin care product, a gel-type skin care product, an emulsion-type skin care product or a cream-type skin care product.
10. A method of preparing a soothing composition according to any of claims 1 to 7 comprising the step of mixing the components of the soothing composition.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010329158.9A CN111419751A (en) | 2020-04-23 | 2020-04-23 | Soothing composition, preparation method thereof and skin care product containing soothing composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010329158.9A CN111419751A (en) | 2020-04-23 | 2020-04-23 | Soothing composition, preparation method thereof and skin care product containing soothing composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111419751A true CN111419751A (en) | 2020-07-17 |
Family
ID=71554452
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010329158.9A Pending CN111419751A (en) | 2020-04-23 | 2020-04-23 | Soothing composition, preparation method thereof and skin care product containing soothing composition |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111419751A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114376932A (en) * | 2022-02-25 | 2022-04-22 | 山东花物堂生物科技有限公司 | Composition for improving stimulation of gamma-aminobutyric acid and preparation method and application thereof |
| CN114617812A (en) * | 2022-03-11 | 2022-06-14 | 广州市南方医康生物科技有限公司 | Method for preparing cosmetic with effects of repairing, relieving and removing red |
| WO2022199510A1 (en) * | 2021-03-23 | 2022-09-29 | 太和康美(北京)中医研究院有限公司 | Alleviating and repairing composition, and preparation method therefor and use thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103315934A (en) * | 2013-06-21 | 2013-09-25 | 深圳市金因生物技术有限公司 | Composition for promoting opening of skin aquaporin and preparation method thereof |
| CN103462881A (en) * | 2013-10-10 | 2013-12-25 | 深圳市金因生物技术有限公司 | Composite capable of promoting skin micro-ecological balance and preparation method thereof |
| CN107970158A (en) * | 2017-12-18 | 2018-05-01 | 广州柏俐臣化妆品有限公司 | A kind of long-drawn-out facial mask and preparation method thereof that ripples of water profit |
| CN110051607A (en) * | 2019-05-28 | 2019-07-26 | 无锡简玺生物科技有限公司 | A kind of Astemizole of the stem extraction containing sequoia sempervirens answers face essence creams |
-
2020
- 2020-04-23 CN CN202010329158.9A patent/CN111419751A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103315934A (en) * | 2013-06-21 | 2013-09-25 | 深圳市金因生物技术有限公司 | Composition for promoting opening of skin aquaporin and preparation method thereof |
| CN103462881A (en) * | 2013-10-10 | 2013-12-25 | 深圳市金因生物技术有限公司 | Composite capable of promoting skin micro-ecological balance and preparation method thereof |
| CN107970158A (en) * | 2017-12-18 | 2018-05-01 | 广州柏俐臣化妆品有限公司 | A kind of long-drawn-out facial mask and preparation method thereof that ripples of water profit |
| CN110051607A (en) * | 2019-05-28 | 2019-07-26 | 无锡简玺生物科技有限公司 | A kind of Astemizole of the stem extraction containing sequoia sempervirens answers face essence creams |
Non-Patent Citations (1)
| Title |
|---|
| 张翼轸: "《品味.男：男人打理手册》", 31 March 2011, 山西人民出版社 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022199510A1 (en) * | 2021-03-23 | 2022-09-29 | 太和康美(北京)中医研究院有限公司 | Alleviating and repairing composition, and preparation method therefor and use thereof |
| CN114376932A (en) * | 2022-02-25 | 2022-04-22 | 山东花物堂生物科技有限公司 | Composition for improving stimulation of gamma-aminobutyric acid and preparation method and application thereof |
| CN114376932B (en) * | 2022-02-25 | 2024-04-16 | 山东花物堂生物科技有限公司 | Composition for improving gamma-aminobutyric acid irritation as well as preparation method and application thereof |
| CN114617812A (en) * | 2022-03-11 | 2022-06-14 | 广州市南方医康生物科技有限公司 | Method for preparing cosmetic with effects of repairing, relieving and removing red |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN109966186B (en) | Soothing and moisturizing repairing composition containing mineral hot spring | |
| CN110200830B (en) | Anti-inflammatory and allergy-relieving repair composition and preparation method and application thereof | |
| CN111419751A (en) | Soothing composition, preparation method thereof and skin care product containing soothing composition | |
| CN108969446B (en) | Infant anti-chap skin care composition for enhancing skin barrier function and preparation method thereof | |
| CN106880551B (en) | Body lotion for tightening, moistening and smoothing skin and preparation method thereof | |
| CN110179730B (en) | Repair cream | |
| CN110025513B (en) | Traceless repairing composition containing mineral hot spring | |
| CN112472653A (en) | Acne-removing aloe gel and preparation method thereof | |
| CN112006958A (en) | Depilatory cream and preparation method thereof | |
| CN111956575A (en) | Skin whitening, anti-aging and moisturizing skin care product containing aloe active substances and preparation method thereof | |
| CN114652884B (en) | Camellia soothing essence disposable hygienic product nursing base material, preparation method and application | |
| CN104523530A (en) | Anti-aging facial mask and preparation method thereof | |
| CN116459191A (en) | Oil-control moisturizing composition and preparation method and application thereof | |
| CN111494270A (en) | Multi-effect relieving essence composition, multi-effect relieving essence lotion and preparation method of multi-effect relieving essence lotion | |
| CN111228154A (en) | Fresh wheat extract protoplasm milk for infants and preparation method thereof | |
| CN113350256B (en) | Plant composition, plant sunscreen lotion and preparation method thereof | |
| CN111643425B (en) | Pure natural plant oil control convergence composition, essence and preparation method thereof | |
| CN115006303A (en) | Anti-allergy moisturizing skin-activating essence lotion and preparation method thereof | |
| CN109431881B (en) | Tibetan sheep oil for preventing skin from being cracked due to dryness | |
| CN112870140A (en) | Anti-allergy itching-relieving composition, skin-care gel, and preparation method and application thereof | |
| CN110812265A (en) | Soothing, repairing and moisturizing essence emulsion | |
| KR102613485B1 (en) | Natural cosmetic and manufacturing method thereof | |
| CN112754974B (en) | Composition with anti-allergy repairing effect and preparation method thereof | |
| CN116889539B (en) | Composition for relieving and resisting allergy, and preparation method and application thereof | |
| CN115671239B (en) | Anti-inflammatory, detumescence, antibacterial, antipruritic, anticracking and repairing jelly-curing cream and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20200717 |
|
| RJ01 | Rejection of invention patent application after publication |